6239:CELE ZC334.10
gene id: 6239:CELE_ZC334.10
uniprot id: Q7JKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T14D7.1
gene id: 6239:CELE_T14D7.1
uniprot id: Q94055
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

6239:CELE K08E4.1
gene id: 6239:CELE_K08E4.1
uniprot id: Q21338
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Interacts with spt-4 to form DSIF. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of cdk-9 and cyclin-T (cit-1.1 or cit-1.2) (By similarity).
messages: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
messages: Nucleus
messages: Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing (By similarity).

6239:CELE C27C12.7
gene id: 6239:CELE_C27C12.7
uniprot id: Q18253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE Y57G11C.13
gene id: 6239:CELE_Y57G11C.13
uniprot id: G5EDC6
names: Subcellular Location Annotation
messages: Lysosome membrane

6239:CELE Y57E12AL.1
gene id: 6239:CELE_Y57E12AL.1
uniprot id: Q95XV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

6239:CELE B0286.4
gene id: 6239:CELE_B0286.4
uniprot id: B2MZA9
uniprot id: Q10923
uniprot id: Q95QZ4
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

6239:CELE Y47H9C.2
gene id: 6239:CELE_Y47H9C.2
uniprot id: Q9XWD7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE T15D6.6
gene id: 6239:CELE_T15D6.6
uniprot id: O02316
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F26A1.2
gene id: 6239:CELE_F26A1.2
uniprot id: Q19802
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage (PubMed:12568714). Expressed in a few neurons in the head of young larvae (PubMed:12568714).
messages: Nucleus
messages: RNAi-mediated knockdown causes significant reduction in the expression of 21U-RNAs, upon simultaneous knockdown of fkh-3 and fkh-4.
messages: Transcription factor (By similarity). Binds to DNA sequence motif 5'-CTGTTTCA-3' (PubMed:22819322). Regulates expression of a class of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4 and fkh-3 (PubMed:22819322).

6239:CELE K08H2.8
gene id: 6239:CELE_K08H2.8
uniprot id: Q21372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C37H5.13
gene id: 6239:CELE_C37H5.13
uniprot id: Q95Q68
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE F20G2.4
gene id: 6239:CELE_F20G2.4
uniprot id: Q93542
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE T06G6.1
gene id: 6239:CELE_T06G6.1
uniprot id: O62367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C27A12.8
gene id: 6239:CELE_C27A12.8
uniprot id: O01965
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity.
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Cytoplasm
messages: E3 ubiquitin-protein transferase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ubc-18 (By similarity). Acts with ubc-18 to regulate pharyngeal development (PubMed:16457801, PubMed:19521497).
messages: Expression is dynamic during early embryonic development, with ubiquitous somatic expression occurring between the 50- and 200-cell stage (PubMed:16457801). By the late proliferative phase of embryogenesis, expression is reduced, but maintained at high levels in muscle precursors (PubMed:16457801). Later in embryogenesis, moderate expression occurs in the lateral ectoderm (PubMed:16457801). Pharyngeal expression is very low at both the comma and 1.5-fold embryonic stages (PubMed:16457801). Expression is highest in muscle and neuronal cells in larvae and adults, including many of the amphid neurons that are proximal to the posterior bulb of the pharynx (PubMed:16457801). Consistent expression in cells of the somatic gonad including distal tip, sheath, and spermathecal cells, as well as in vulval cells undergoing morphogenesis (PubMed:16457801). Neuronal expression in the midbody includes the CAN, HSN, and ALM cells; neurons of the ventral and dorsal cords; and a number of posterior deirid neurons (PubMed:16457801). Expressed in all pairs of coelomocytes (PubMed:16457801).
messages: Interacts with ubiquitin-conjugating enzyme E2 ubc-18.
messages: Members of the RBR family are atypical E3 ligases. They interact with an E2 conjugating enzyme and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Nucleus
messages: RNAi-mediated knockdown on a pha-1 or on a lin-35;ubc-18 mutant background produces a high percentage of animals with the Pun (pharyngeal unattached) phenotype, whereby the pharynx fails to elongate and form an attachment to the anterior alimentary opening or buccal cavity.

6239:CELE Y67A6A.2
gene id: 6239:CELE_Y67A6A.2
uniprot id: O02279
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed from embryo to adult in the pharynx and intestine.
messages: Nucleus
messages: Orphan nuclear hormone receptor (PubMed:23935515). Required for metabolic and physiologic responses associated with dietary-restriction-induced longevity (PubMed:23935515). Modulates triglyceride and lipid metabolism and autophagy, associated with dietary-restriction, probably acting via regulation of transcription of target genes (PubMed:23935515).
messages: RNAi-mediated knockdown suppresses the longevity caused by an eat-2 mutant background.
messages: Widely expressed at a low level in many tissues including the pharynx, sensory neurons, intestine, spermatheca, hypodermis, and excretory cell.

6239:CELE T27A3.2
gene id: 6239:CELE_T27A3.2
uniprot id: P91502
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE ZK809.2
gene id: 6239:CELE_ZK809.2
uniprot id: Q23598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

6239:CELE F49E12.1
gene id: 6239:CELE_F49E12.1
uniprot id: Q20616
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Exclusively expressed in hypodermis.
messages: Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis.
messages: Knockouts show increased susceptibility to infection with E.faecalis but not with P.aeruginosa, increased levels of H(2)O(2) upon infection and a slightly shorter life span. Fertile animals show a bagging phenotype due to embryos being retained in the body and an increase of clec-60 mRNA levels upon infection. 50% of knockouts also have a dumpy phenotype. RNAi-mediated knockdown of the protein also results in higher susceptibility to infection by E.faecalis but not in a decreased life span or morphological changes.

6239:CELE K04G11.2
gene id: 6239:CELE_K04G11.2
uniprot id: G5EGS7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in seam cells with temporal changes in expression level; undetectable in L1 and L2 larval stages, then expressed at the L3 stage, declining at the late L4 stage and expressed only weakly in young adults (PubMed:19500563). Expressed in the vulval precursor cells (VPCs) (PubMed:15020414).
messages: Multimer (PubMed:15020414). May interact with mediator complex subunit mdt-29 (PubMed:15020414).
messages: Nucleus
messages: Putative transcription factor (PubMed:19500563). Positive regulator of the lin-12/Notch signaling pathway (PubMed:15020414). Binds to specific DNA sequences in regulatory elements (PubMed:19500563). Involved in cell fate decisions that require cell-cell interactions, such as the anchor cell (AC) / ventral uterine (VU) precursor cell fate decision (PubMed:15020414). Heterochronic protein which controls the choice of stage specific cell fates, including the larval L3 stage-specific fate of seam cells (PubMed:19500563). Involved in regulating the temporal expression pattern of hunchback-like protein hbl-1, thereby playing a role in the progression between larval stages L2 and L3 (PubMed:19500563).
messages: RNAi-mediated knockdown suppresses the hermaphrodite gonadal development and egg-laying defects in a lin-12 mutant background.
messages: Widely expressed, including in pharyngeal muscle cells and body wall muscle cells.

6239:CELE ZC434.4
gene id: 6239:CELE_ZC434.4
uniprot id: Q23314
names: Similarity
messages: Belongs to the RRP7 family.

6239:CELE K06B4.1
gene id: 6239:CELE_K06B4.1
uniprot id: O17927
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K10B3.7
gene id: 6239:CELE_K10B3.7
uniprot id: P17330
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

6239:CELE T07E3.6
gene id: 6239:CELE_T07E3.6
uniprot id: G8JYC6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Conditional knockdown in AVB, PVP, and SIAV neurons reduces exploratory roaming behavior.
messages: Expressed throughout postembryonic life (PubMed:19686386). Expressed in hermaphrodites in the interneurons ADAL/R and PVT, the chemosensory neuron pairs ASI, ASK, PHA and PHB, the RMED, RMEV and RID motor neurons, the sensory neuron pair ADE, the PQR mechanosensory neuron and in the PVPL/R interneurons (PubMed:19686386, PubMed:23764289). Also expressed in rectal gland cells rectD and rectVL/R, and the intestino-rectal valve cells virL/R (PubMed:19686386). Expressed in both sexes in the head interneurons SAAV, SAAD, SIAV, AVB, AIM, RMG, and in the tail in the interneurons PVN, LUA, PVT, and the pair PVS and PVU (referred to as PVP left and right in the hermaphrodite) (PubMed:23143519, PubMed:23764289, PubMed:23972393). Expressed in male-specific ventral cord neurons CP7 and CP8, and PDC (PubMed:23143519). Expression from the AIM interneurons in males is involved in mate searching behavior (PubMed:23143519).
messages: Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor (PubMed:18390545). May not signal through isoform c of pdfr-1 (PubMed:18390545). Involved in locomotion; more specifically mate searching behavior of males, independent of nutritional status (PubMed:18390545, PubMed:22579613, PubMed:23143519, PubMed:30024377). Involved in regulating the male-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons (PubMed:30024377). Plays a role in circadian rhythms of locomotor activity (PubMed:26113231). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide flp-2 (PubMed:23764289, PubMed:27585848). In the presence of food, plays a role in initiating and extending exploratory roaming behavior, in opposition to 5-hydroxytryptamine (serotonin) signaling.
messages: Secreted

6239:CELE R11H6.2
gene id: 6239:CELE_R11H6.2
uniprot id: O45719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

6239:CELE R13G10.1
gene id: 6239:CELE_R13G10.1
uniprot id: P48996
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development (PubMed:7954812, PubMed:3779843, PubMed:26641248, PubMed:8939870, PubMed:14660541, PubMed:22393255, PubMed:19119011). Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase (PubMed:8939870). Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome (PubMed:14660541, PubMed:9458050). Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes (PubMed:22393255). As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488). Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442).
messages: Chromosome
messages: Component of the dosage compensation complex, which contains the mix-1/SMC2 and dpy-27/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:8939870, PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011). Within the complex, interacts with dpy-28, mix-1, dpy-26 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:9458050, PubMed:28301465). Interacts with dpy-21 (PubMed:14660541). Interacts with dpy-28; the interaction is required for dpy-28 protein stability and dpy-28 association with the X chromosome (PubMed:18198337). Interacts with smcl-1 (PubMed:28301465).
messages: Consists of two putative central coiled-coil regions flanked by putative globular regions at the N- and C-termini.
messages: Expressed in embryos and early-staged larvae (PubMed:7954812). Also expressed in adult gut nuclei (PubMed:14660541).
messages: Nucleus
messages: RNAi-mediated knockdown causes derepression of X chromosome linked genes in embryos and in larval stages L1 and L3 (PubMed:26641248). Leads to an increase of 'Lys-16' acetylation of histone H4 (H4K16ac) on hermaphrodite X chromosomes (PubMed:22393255). In the TOR complex 2 mutant background rict-1, suppresses the growth delay and elevated body fat index (PubMed:23884442). In a sex-1 mutant background, leads to high XX-specific embryonic lethality (PubMed:19119011).

6239:CELE F18A11.1
gene id: 6239:CELE_F18A11.1
uniprot id: O01322
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Puf-6 and puf-7 are >98% identical on both nucleotide and protein sequence level. Experimental approaches often do not distinguish between the two genes, which are collectively referred to as puf6/7 and are considered to be functionally redundant.
messages: RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.
messages: Simultaneous knockdown of puf-6 and puf-7 results in ectopic primordial germ cells (PGCs) outside the somatic gonads, premature PGC proliferation in L1 larvae and germ cell death. Does not affect germline development in adult hermaphrodites. Disruption with puf-5 and puf-7 results in abnormally small oocytes, disorganization of oocyte nuclei and cells, inefficient yolk uptake by oocytes, embryonic arrest with impaired eggshell formation and cytokinesis defects, impaired repression of glp-1 in late oogenesis, and mislocalization of rme-2 to the cytoplasm instead of the plasma membrane.

6239:CELE F58H7.2
gene id: 6239:CELE_F58H7.2
uniprot id: O45089
names: Similarity
messages: Belongs to the amidase family.

6239:CELE C50D2.4
gene id: 6239:CELE_C50D2.4
uniprot id: O44796
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C46A5.9
gene id: 6239:CELE_C46A5.9
uniprot id: G5EC23
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in embryos and the L1 larval stage (at protein level) (PubMed:11341844, PubMed:18828672). Expressed in embryos and adults, with lower levels in L1-L4 larvae (PubMed:9858614, PubMed:14629117).
messages: Interacts with daf-16/FOXO (PubMed:18828672). Interacts with deacetylase sir-2.1 (PubMed:21909281). Interacts with the 14-3-3 family proteins ftt-2 and par-5 (PubMed:21909281).
messages: Nucleus
messages: Phosphorylated at multiple serine residues (PubMed:11341844). Phosphorylation is developmentally regulated, occurring in embryos but not L1 larvae (PubMed:11341844). Phosphorylation may be cell-cycle-regulated (PubMed:11341844).
messages: RNAi-mediated knockdown causes 20-30% increase in lifespan (PubMed:18828672). Causes smaller brood size (50% of wild type) and lower hatching rate (21% vs. 99%) at 12 degrees Celsius (PubMed:18043729). Increases intestinal expression of skn-1 target genes, including gcs-1, gst-4 and gst-7; increase abolished in an skn-1 mutant background (PubMed:22568582). Substantially reduces enrichment of hcf-1 on the efl-1 promoter and enhances enrichment of daf-16 at sod-3 and mtl-1 promoters (PubMed:18828672). Two-fold reduction in the level of embryonic expression of sup-35 in a lin-35 mutant background (PubMed:19521497). Partial suppression of larval lethality in both lin-35;ubc-18 and lin-35;pha-1 mutant backgrounds and suppression of pharynx-unattached phenotypes in a pha-1 mutant background (PubMed:19521497).
messages: Transcriptional coregulator (PubMed:18828672). Involved in control of the cell cycle and in modulating mitotic histone phosphorylation (PubMed:18043729). Plays a role in modulating lifespan by regulating the transcriptional activity of daf-16/Forkhead box protein O, in concert with protein deacetylase sir-2.1/SIRT1, and perhaps acting independently of the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:18828672, PubMed:21909281). Negatively modulates responses to environmental stresses, including oxidative stress, heat stress, and exposure to heavy metals; acting via regulation of the transcription factors daf-16 and skn-1 (PubMed:18828672, PubMed:21909281, PubMed:22568582). May play a role in pharyngeal development via positive modulation of expression of sup-35 (PubMed:19521497).

6239:CELE F32A7.6
gene id: 6239:CELE_F32A7.6
uniprot id: P91863
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Probable serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:16945111). May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:16945111). In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ) (PubMed:11804572). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:2323555, PubMed:11804572, PubMed:18852466, PubMed:25849533). Probably by regulating DMP, required for fatty acid uptake by intestinal cells and therefore regulates the levels of triglycerides in the intestine (PubMed:25849533). Plays a role in locomotion (PubMed:11804572).
messages: RNAi-mediated knockdown causes a reduction in fatty acid uptake (PubMed:25849533). RNAi-mediated knockdown in the intestine causes a severe defect in the expulsion step of the defecation cycle (PubMed:18852466).
messages: Secreted

6239:CELE Y102A5A.1
gene id: 6239:CELE_Y102A5A.1
uniprot id: G5ED41
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAND family.
messages: In early embryos, expressed in all cells. Expression is higher during early stages and is reduced in late-stage embryos. Present in the one-cell stage zygote, indicating it is provided as a maternal product by the hermaphrodite parent. During larval stages, expressed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. Also observed in a subset of non-proliferative tissues, including hypodermal cells (at protein level).
messages: Interacts with cul-1, cul-2, cul-3, cul-4, cul-5 and cul-6.
messages: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
messages: Nucleus
messages: Worms show impenetrant phenotypes, including developmental arrest, morphological defects of the vulva and tail and reduced fecundity. Worms also display supernumerary seam cell divisions, defective alae formation, and the accumulation of the SCF(lin-23) target, the glutamate receptor glr-1. Increased levels of the neddylated isoforms of Cul-2 and cul-4.

6239:CELE F21H12.6
gene id: 6239:CELE_F21H12.6
uniprot id: Q09541
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase S8 family.
messages: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Has a role in regulation of fat storage.
messages: Expressed in intestinal fat-storing cells and some head neurons.
messages: RNAi-mediated knockdown causes reduced fat storage but does not affect feeding behavior.

6239:CELE T08D2.7
gene id: 6239:CELE_T08D2.7
uniprot id: A4F324
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE H24K24.3
gene id: 6239:CELE_H24K24.3
uniprot id: Q17335
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Plays a role in the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus (PubMed:30014846).
messages: Cytoplasm
messages: Homodimer.

6239:CELE Y82E9BR.18
gene id: 6239:CELE_Y82E9BR.18
uniprot id: Q9BKR5
names: Similarity
messages: Belongs to the NEMF family.

6239:CELE ZK563.7
gene id: 6239:CELE_ZK563.7
uniprot id: Q4TTB1
names: Similarity
messages: Belongs to the apyrase family.

6239:CELE Y54F10BM.1
gene id: 6239:CELE_Y54F10BM.1
uniprot id: Q95XK4
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE Y87G2A.14
gene id: 6239:CELE_Y87G2A.14
uniprot id: Q9NA25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family.
messages: Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine.
messages: Peroxisome membrane

6239:CELE C18B12.3
gene id: 6239:CELE_C18B12.3
uniprot id: Q93246
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the bilateral sensory neurons AWA, AWB, AWC, ASE, FLP and PVD. Also expressed in the enteric intestinal and anal depressor muscles.
messages: Nucleus
messages: Shortened defecation cycle length with change in periodicity of the cycle. Expulsion defective with distended gut and lack of enteric muscle contractions due to lack of exp-1 expression.
messages: Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle.
messages: axon

6239:CELE K08C9.4
gene id: 6239:CELE_K08C9.4
uniprot id: Q9XUT4
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE E04D5.4
gene id: 6239:CELE_E04D5.4
uniprot id: G5ECJ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F13C5.5
gene id: 6239:CELE_F13C5.5
uniprot id: O76565
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01H8.1
gene id: 6239:CELE_T01H8.1
uniprot id: G5EE78
uniprot id: Q21734
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Autophosphorylated on Ser-422, as part of the activation process.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: RNAi-mediated knockdown in lip-1 and puf-8 double mutant causes a decrease in number of germline tumors and restores normal microtubule organization in spermatocytes.
messages: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 (PubMed:22820175).

6239:CELE Y47D3A.23
gene id: 6239:CELE_Y47D3A.23
uniprot id: Q9U2C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE C17G10.1
gene id: 6239:CELE_C17G10.1
uniprot id: Q09973
names: Similarity
messages: Belongs to the TPA1 family.

6239:CELE T01E8.9
gene id: 6239:CELE_T01E8.9
uniprot id: Q7YWU9
names: Developmental Stage
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed at L4 larval stage and to a lesser extent in adults.
messages: Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Interacts with atx-3 (via C-terminus). Interacts with cdc-48.1 (via N-terminus) and cdc-48.2.
messages: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Unlike other UBX domain-containing protein does not bind 'Lys-48'-polyubiquitinated chain.
messages: Specifically expressed in the germline.

6239:CELE F36H2.3
gene id: 6239:CELE_F36H2.3
uniprot id: A0A1N7SYP5
uniprot id: A0A1N7SYV9
uniprot id: H2L2F0
uniprot id: H2L2F1
uniprot id: H2L2F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F23F12.10
gene id: 6239:CELE_F23F12.10
uniprot id: P46506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE T11F8.3
gene id: 6239:CELE_T11F8.3
uniprot id: O44191
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F18G5.3
gene id: 6239:CELE_F18G5.3
uniprot id: Q19572
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families (PubMed:22470487, PubMed:19380113). Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:19380113).
messages: Up-regulation of nlp-29 is severely impaired in the hyp7 epidermal cell but not in vulva epidermal cells following fungal infection by D.coniospora or physical injury.

6239:CELE Y45G5AM.2
gene id: 6239:CELE_Y45G5AM.2
uniprot id: Q9GUI6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24B family.
messages: Expressed in germ cells of L4 larvae (PubMed:33231880). Expressed at low levels in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880).
messages: May interact with pid-2, app-1 and prmt-5.
messages: P-body
messages: Together with pid-4, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-4, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-4, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-4, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880).
messages: perinuclear region

6239:CELE C09H10.3
gene id: 6239:CELE_C09H10.3
uniprot id: Q17880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

6239:CELE Y37D8A.6
gene id: 6239:CELE_Y37D8A.6
uniprot id: Q9XWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE D2013.2
gene id: 6239:CELE_D2013.2
uniprot id: Q18964
names: Disruption Phenotype
names: Function
messages: Plays a role in coelomocyte endocytosis.
messages: Worms exhibit disruption of coelomocyte endocytosis.

6239:CELE ZK265.2
gene id: 6239:CELE_ZK265.2
uniprot id: Q94399
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZC334.11
gene id: 6239:CELE_ZC334.11
uniprot id: Q7JKM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F26E4.4
gene id: 6239:CELE_F26E4.4
uniprot id: P90847
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F42D1.2
gene id: 6239:CELE_F42D1.2
uniprot id: Q93703
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Expressed in the muscle (PubMed:18227072). Expressed in the hypodermis and intestine (PubMed:18227072, PubMed:24385923).
messages: Homodimer.
messages: RNAi-mediated knockdown increases lifespan by 17.8%, and reduces tyrosine aminotransferase activity by 75% thus increasing tyrosine levels (PubMed:24385923, PubMed:31043480). RNAi-mediated knockdown delays reproductive adult development in response to oxidative stress induced by the superoxide paraquat (PubMed:31043480). RNAi-mediated knockdown increases dauer formation in eak-4 mg348, eak-3 mg344, eak-5 mg337, eak-2 mg433, or eak-7 tm3188 mutant backgrounds at 25 degrees Celsius (PubMed:24385923). RNAi-mediated knockdown increases aak-2 phosphorylation, but does not impair energy production in a eak-4 mg348 mutant background (PubMed:24385923). RNAi-mediated knockdown results in a reduced lifespan in an aak-2 gt33 mutant background (PubMed:24385923). RNAi-mediated knockdown results in reduced dauer formation in an eak-4 mg348 and aak-2 gt33 mutant background (PubMed:24385923). RNAi-mediated knockdown extends the lifespan of eak-7 tm3188 mutants (PubMed:24385923). RNAi-mediated knockdown together with fah-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).
messages: Transaminase involved in tyrosine breakdown (PubMed:24385923, PubMed:31043480). Converts tyrosine to p-hydroxyphenylpyruvate (PubMed:31043480). Has no transaminase activity towards phenylalanine (PubMed:31043480). Plays protective role against oxidative stress, metabolizing meta-tyrosine and negatively regulating its accumulation (PubMed:31043480). Plays a role in modulating the daf-2/insulin receptor-like transduction pathway through regulating tyrosine levels (PubMed:24385923). Negatively regulates dauer formation (PubMed:24385923). Plays a role in longevity (PubMed:24385923, PubMed:31043480).
messages: Up-regulated in response to oxidative stress.

6239:CELE F38H12.3
gene id: 6239:CELE_F38H12.3
uniprot id: O16346
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y54E10BR.1
gene id: 6239:CELE_Y54E10BR.1
uniprot id: G4SNP0
uniprot id: Q9N3C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F44G4.8
gene id: 6239:CELE_F44G4.8
uniprot id: G5EGJ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
messages: Initially expressed in vulva precursor cells P5.p, P6.p and P7.p. Expression is later restricted to P5.px and P7.px and their descendants P5.pxx and P7.pxx with higher levels in the cells proximal to P6.p descendants.
messages: Interacts with pat-2.
messages: Membrane
messages: Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system (PubMed:15901674). By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p (PubMed:15901674). Similarly, may prevent duct cell fate in ABpr precursor (PubMed:15901674). Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction (PubMed:28135265). In particular, by dephosphorylating pat-3, promotes the recruitment (by unphosphorylated pat-3) of the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells (PubMed:28135265). This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells thereby attenuating let-23 signaling (PubMed:28135265).
messages: RNAi-mediated knockdown in a lip-1 zh15 mutant background causes the descendants of P5.p and/or P7.p vulva precursor cells to adopt a mixed primary and secondary cell fate. Multivulva formation in 19 percent of animals. RNAi-mediated knockdown in a let-23 sy-1 mutant background partially restores vulva induction.

6239:CELE F09D1.1
gene id: 6239:CELE_F09D1.1
uniprot id: O44787
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T21E3.3
gene id: 6239:CELE_T21E3.3
uniprot id: O01768
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K10D3.3
gene id: 6239:CELE_K10D3.3
uniprot id: Q21417
names: Similarity
messages: Belongs to the TAF11 family.

6239:CELE F29B9.1
gene id: 6239:CELE_F29B9.1
uniprot id: Q9GYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

6239:CELE Y62E10A.6
gene id: 6239:CELE_Y62E10A.6
uniprot id: Q9U1X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

6239:CELE ZK792.2
gene id: 6239:CELE_ZK792.2
uniprot id: Q23593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE T07C5.2
gene id: 6239:CELE_T07C5.2
uniprot id: Q22298
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F22G12.5
gene id: 6239:CELE_F22G12.5
uniprot id: A0A0K3AR51
uniprot id: G1K0Y1
uniprot id: G5EBE8
names: Similarity
messages: Belongs to the DOCK family.

6239:CELE C52E12.1
gene id: 6239:CELE_C52E12.1
uniprot id: Q18782
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

6239:CELE F58G11.6
gene id: 6239:CELE_F58G11.6
uniprot id: Q9XVL8
names: Similarity
messages: Belongs to the CCZ1 family.

6239:CELE Y71G12B.1
gene id: 6239:CELE_Y71G12B.1
uniprot id: Q95XL8
uniprot id: Q95XL9
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y40B1B.7
gene id: 6239:CELE_Y40B1B.7
uniprot id: Q9XWP4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F32H5.7
gene id: 6239:CELE_F32H5.7
uniprot id: G5EEH1
uniprot id: K8ERV0
uniprot id: K8ESK0
uniprot id: K8FDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y47G6A.7
gene id: 6239:CELE_Y47G6A.7
uniprot id: Q6AW10
uniprot id: Q9N3S9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12A2.12
gene id: 6239:CELE_T12A2.12
uniprot id: P54126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE ZK863.2
gene id: 6239:CELE_ZK863.2
uniprot id: G5ECU6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F52D10.5
gene id: 6239:CELE_F52D10.5
uniprot id: Q20657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

6239:CELE F42A10.5
gene id: 6239:CELE_F42A10.5
uniprot id: Q20310
names: Similarity
messages: Belongs to the CDV3 family.

6239:CELE F59B8.2
gene id: 6239:CELE_F59B8.2
uniprot id: H9G2T4
uniprot id: Q21032
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

6239:CELE Y38F2AR.9
gene id: 6239:CELE_Y38F2AR.9
uniprot id: Q95XS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

6239:CELE C08B11.2
gene id: 6239:CELE_C08B11.2
uniprot id: Q09440
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: May be a component of a histone deacetylase complex containing saeg-2, saeg-1 and hda-2.
messages: Nucleus
messages: Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and forgaging (PubMed:21573134).

6239:CELE F58B3.6
gene id: 6239:CELE_F58B3.6
uniprot id: Q20965
names: Similarity
messages: Belongs to the IFRD family.

6239:CELE C02B4.1
gene id: 6239:CELE_C02B4.1
uniprot id: G5ECS8
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: In hermaphrodites, expressed in the vulva, head ganglia, ventral nerve cord and amphid neurons. Expressed in the rays of the male tail.
messages: Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle.
messages: Secreted
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

6239:CELE Y66D12A.20
gene id: 6239:CELE_Y66D12A.20
uniprot id: Q95PZ9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
messages: Serine/threonine-protein kinase which is involved in spermatogenesis (PubMed:12019230, PubMed:8417991, PubMed:29879108). In spermatocytes, regulates meiosis and the localization and assembly of major sperm protein (MSP) into fibrous bodies (PubMed:12019230, PubMed:8417991). In addition, may suppress the initiation of spermiogenesis downstream of spe-8, spe-12, spe-27 and spe-29 (PubMed:12019230).

6239:CELE F26B1.7
gene id: 6239:CELE_F26B1.7
uniprot id: P91278
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Embryonic lethality; those few animals that survive to adulthood lack functional embryonic and M lineage (mesoblast-cell) derived coelomocytes (CCs) (PubMed:20335356). RNAi-mediated knockdown abolishes expression of ceh-34 in the M lineage (PubMed:20335356).
messages: Expression begins during embryogenesis and persists in a small number of cells throughout larval development (at protein level) (PubMed:20335356). Expressed transiently in the postembryonic non-gonadal mesoderm (M lineage), first detected in M.dlp and M.drp as they begin to divide (PubMed:20335356).
messages: Nucleus
messages: Transcription factor that is required for cell fate of coelomocytes which are non-muscle mesodermal cells (PubMed:20335356). Acts in concert with, and by activating expression of, the homeodomain gene ceh-34 (PubMed:20335356). Binds to the sequence motif 5'-ATAAA[T/C]A-3' (PubMed:20335356).

6239:CELE C26F1.2
gene id: 6239:CELE_C26F1.2
uniprot id: Q27472
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE ZK678.5
gene id: 6239:CELE_ZK678.5
uniprot id: Q94129
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE F18E2.5
gene id: 6239:CELE_F18E2.5
uniprot id: Q9XTB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE ZC190.1
gene id: 6239:CELE_ZC190.1
uniprot id: G5EES1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

6239:CELE T06D10.2
gene id: 6239:CELE_T06D10.2
uniprot id: Q9U380
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K09A11.2
gene id: 6239:CELE_K09A11.2
uniprot id: Q27506
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C15A11.7
gene id: 6239:CELE_C15A11.7
uniprot id: Q93211
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F53G12.1
gene id: 6239:CELE_F53G12.1
uniprot id: O01803
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic granule
messages: Endosome
messages: Expressed during embryogenesis (PubMed:18385514, PubMed:20116245, PubMed:26506309). Transiently expressed during cytokinesis in embryos on the ingressing furrow and at the midbody during early abscission (PubMed:20116245). Expressed during the L4 stage and young adult stage of development (PubMed:22634595).
messages: Expressed weakly in sperm, but more predominantly in oocytes (PubMed:18472420). Expressed in the intestine (PubMed:24843160).
messages: Golgi apparatus membrane
messages: Interacts with rei-1 and rei-2. The GDP-form preferentially binds to rei-1 and rei-2.
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21320697, PubMed:24843160). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21320697, PubMed:24843160). Involved in regulating the meiotic maturation of oocytes (PubMed:18472420). Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization (PubMed:18765566, PubMed:26506309). Controls cortical granule localization and targets them to the plasma membrane for exocytosis (PubMed:18765566, PubMed:22992455). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:18765566, PubMed:20116245, PubMed:26506309). Regulates the cytoskeleton by facilitating astral microtubule elongation and organization during metaphase to ensure proper spindle alignment and polarity in the first embryonic cell division (PubMed:18385514). Maintains normal endoplasmic reticulum morphology during metaphase (PubMed:18385514). Involved in vesicle formation and plasma membrane repair following exposure to pore forming toxins (PubMed:21320697). Regulates endocytic recycling (PubMed:24843160). May play a role in yolk receptor endocytosis in growing oocytes (PubMed:18354496, PubMed:26506309). Plays a role in the shedding of pathogen spores from intestinal cells via its involvement in spore fusion and endocytic trafficking (PubMed:24843160).
messages: Zygotic lethal (PubMed:18765566). RNAi-mediated knockdown results in a reduced meiotic maturation rate of oocytes (PubMed:18472420). Embryos are multinucleated and osmotically sensitive with permeable and therefore defective eggshells (PubMed:18765566, PubMed:18385514). During the first cell cycle, 52% of embryos fail to extrude polar bodies, 83% of embryos display no or minimal pseudocleavage and the centrosomal-nuclear complex does not migrate to the center of embryos (PubMed:18385514). Animals display mitotic spindle alignment defects whereby in 73.9% of embryos, the P0 spindle does not rotate to the anterior-posterior axis of the embryo during anaphase, but during the metaphase to anaphase transition, the movements of the spindle are more abrupt with the spindle migrating to the posterior pole and then rebounding to the anterior-posterior axis (PubMed:18385514). In 17.4% of embryos the centrosomes are unstable and the spindle is displaced further towards the posterior pole (PubMed:18385514). Impaired localization of proteins important for establishing cell polarity such as par-2, par-3, gpr-1 and gpr-2 (PubMed:18385514). Altered microtubule organization and dynamics during metaphase including a greater distance between the growing microtubule plus ends and the posterior cortex, impeded microtubule growth with fewer growing astral microtubules reaching the cortex, and a reduced microtubule nucleation rate (PubMed:18385514). Slight defect in endoplasmic reticulum morphology whereby the large endoplasmic reticulum aggregates that normally form during metaphase and persist during anaphase, form, but do not persist during anaphase and disperse (PubMed:18385514). Mild endocytosis defect with an accumulation of the yolk protein vitellogenin in the pseudocoelom (PubMed:18354496). Impaired cortical granule (secretory vesicle) localization with granules abnormally clustered around the nuclear envelope of proximal oocytes, irregulary dispersed in the cytoplasm of oocytes a…
messages: centrosome
messages: cytosol
messages: secretory vesicle
messages: spindle
messages: spindle pole body

6239:CELE F13D12.6
gene id: 6239:CELE_F13D12.6
uniprot id: P52715
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE F38E11.2
gene id: 6239:CELE_F38E11.2
uniprot id: G5EE36
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F39H11.3
gene id: 6239:CELE_F39H11.3
uniprot id: P90866
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F37A8.5
gene id: 6239:CELE_F37A8.5
uniprot id: Q9U3G6
names: Similarity
messages: Belongs to the yippee family.

6239:CELE ZK1251.3
gene id: 6239:CELE_ZK1251.3
uniprot id: Q23431
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

6239:CELE F08B6.4
gene id: 6239:CELE_F08B6.4
uniprot id: P37806
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a negative regulator of myosin-dependent contractility of smooth muscle-like cells in the somatic gonad.
messages: Belongs to the calponin family.
messages: Calponin-like repeats 1-3 are required for actin binding and acting bundling activity.
messages: Defects in the structure and function of body wall muscle, resulting in variable paralysis (PubMed:7929573). Disorganization of the A- and I-bands of the myofilament lattice and accumulation of thin filaments in body wall muscles in adult animals (PubMed:7929572). More densely aligned myosin filaments indicating higher contractility of the actomyosin network (PubMed:25717181). Excessive contraction of the myoepithelial sheath (PubMed:25717181).
messages: Expressed in the body wall muscles (PubMed:17684058). Isoform a: Expression in the pharynx, anal depressor muscle, uterine muscle, vulva and unidentified neurons in the head and the ventral region (PubMed:25717181). Isoform b: Expression in the body wall muscles, spermatheca, vulva and in the myoepithelial sheath (PubMed:25717181).
messages: I band
messages: Monomer (PubMed:11096113). Interacts with F-actin (PubMed:11096113, PubMed:25717181). Interacts with myosin (PubMed:25717181).
messages: Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics (PubMed:7929573, PubMed:7929572, PubMed:11096113, PubMed:17684058, PubMed:25717181). Exhibits F-actin cross-linking activity (PubMed:11096113, PubMed:17684058). Required for the maintenance of sarcomeric actin organization in striated muscles (PubMed:7929573, PubMed:7929572). Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability (PubMed:17684058). Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility (PubMed:25717181). Might protect the myofilaments from mechanical stress (PubMed:7929572).

6239:CELE T06G6.9
gene id: 6239:CELE_T06G6.9
uniprot id: O18054
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE W02C12.3
gene id: 6239:CELE_W02C12.3
uniprot id: H2KZZ2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MiT/TFE family.
messages: Cytoplasm
messages: Expressed in the intestine and at lower levels in other tissues, including the spermatheca and the vulva (PubMed:19632181, PubMed:23604316). Expressed in cholinergic motor neurons (PubMed:34323215).
messages: Expressed throughout development (PubMed:24882217). In L4 larvae and young adults, expression is highest in the intestine, rectal epithelial cells, vulval epithelial cells, spermathecae, and pharynx and absent from the gonads (PubMed:24882217).
messages: Homodimer.
messages: Nucleus
messages: RNAi-mediated knockdown in adults reduces lifespan on eat-2, daf-2 and rsks-1 mutant backgrounds (PubMed:23925298). RNAi-mediated knockdown during the fourth larval stage reduces lifespan on a clk-1 mutant background (PubMed:23925298). RNAi-mediated knockdown reduces the expression of mml-1 on a glp-1 mutant background (PubMed:27001890). RNAi-mediated knockdown increases expression of lmp-1 and sqst-1 (PubMed:23925298).
messages: Transcription factor which regulates the expression of genes involved in lipid metabolism and autophagy in response to nutrient availability, bacterial pore-forming toxins or heat shock (PubMed:23604316, PubMed:23925298, PubMed:27001890, PubMed:27875098, PubMed:28198373). Binds to the E-box motif 5'-CACGTG-3' (PubMed:19632181). Under fasting conditions, binds to the promoter and activates the expression of lipase genes lipl-2, lipl-3 and lipl-5, and to a lesser extent, lipl-1, thereby regulating lipolysis (PubMed:23604316). Involved in modulating longevity in response to TOR signaling, dietary restriction, germline signaling, heat shock and the insulin-like signaling pathway (PubMed:23925298, PubMed:27001890, PubMed:24882217, PubMed:28198373). Involved in the immune response to infection by the S.aureus bacterium, probably acting downstream of the protein kinase dkf-1, leading to the transcriptional activation of host defense genes (PubMed:24882217, PubMed:27184844). May also play a role in lysosomal biogenesis in response to nutrient availability (PubMed:23604316).
messages: Up-regulated by fasting.

6239:CELE ZK792.3
gene id: 6239:CELE_ZK792.3
uniprot id: Q23594
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C09D4.5
gene id: 6239:CELE_C09D4.5
uniprot id: O02639
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

6239:CELE F43D9.5
gene id: 6239:CELE_F43D9.5
uniprot id: Q20361
names: Similarity
messages: Belongs to the TAF11 family.

6239:CELE C23G10.3
gene id: 6239:CELE_C23G10.3
uniprot id: P48152
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

6239:CELE C10G8.6
gene id: 6239:CELE_C10G8.6
uniprot id: Q94165
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcription regulator (PubMed:20713707). Binds to the sequence motif 5'-TCAGGTT-3' (PubMed:20335356). Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis (PubMed:20713707). Also promotes apoptosis of I1 pharyngeal neuron sister cell (PubMed:20713707). Together with eya-1, required to specify the coelomocyte fate in embryonic and postembryonic precursors (PubMed:19427847, PubMed:20335356).
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expression starts at the embryonic bean stage and continues throughout larval and adult stages in few anterior body wall muscle cells and in unidentified cells in the head (PubMed:19427847). Expressed predominantly in pharyngeal cells during embryogenesis and throughout larval and adult stages (PubMed:20713707). In L1 larvae, expressed in all pharyngeal neurons (M4, I1, MI, I3, M3, NSM, MC, I2, I4, I5, I6, M1, M2, and M5), some pharyngeal muscle cells (pm1 and pm2) and pharyngeal epithelial cells (e1 and e3), and some body wall muscles around the anterior pharynx (PubMed:20713707). Expressed transiently in the M lineage-derived coelomocyte precursor cells M.dlpa and M.drpa before their differentiation into coelomocytes (PubMed:19427847, PubMed:20335356). Expressed in the M4 motor neuron sister cell (PubMed:20713707).
messages: Interacts (via N-terminus) with eya-1 (via C-terminus).
messages: Nucleus
messages: RNAi-mediated knockdown in embryos causes lethal arrest at the embryonic 3-fold stage or at the L1 larval stage with abnormal anterior morphology (PubMed:19427847). The few surviving animals lack 1 or both pairs of embryonic MS lineage-derived coelomocytes as well as the 2 post embryonic M lineage-derived coelomocytes (PubMed:19427847). RNAi-mediated knockdown in L1 larvae causes the loss of the M lineage-derived coelomocytes due to the abnormal differentiation of coelomocyte precursors M.drpa and M.dlpa into body wall muscle cells (PubMed:19427847). In 38 percent of animals, the motor neuron M4 sister survived (PubMed:20713707).

6239:CELE F53B2.6
gene id: 6239:CELE_F53B2.6
uniprot id: G5EEC5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: First expressed at the onset of gastrulation, approximately 100 minutes after cleavage of the zygote (at protein level) (PubMed:8951066). Expressed in both Q.a and Q.p neuroblasts as well as in their neighboring cells (PubMed:23946438).
messages: Nucleus
messages: Probable transcription factor (PubMed:23946438). Required for asymmetric cell division in neuroblasts, perhaps acting by regulating spindle positioning and myosin polarization, and thus the position of the cleavage plane (PubMed:3200316, PubMed:18505863, PubMed:8951066, PubMed:26703426, PubMed:15979607, PubMed:23946438). Required to produce daughter cell size asymmetry in neuroblasts undergoing asymmetric cell division, usually giving rise to one precursor cell and one apoptotic cell (PubMed:29668718, PubMed:15979607, PubMed:23946438). Positively modulates expression of the serine/threonine kinase pig-1/MELK during asymmetric division of the Q.a neuroblast (PubMed:23946438). Plays a role in neural fate specification in several dopaminergic lineages, including the hermaphrodite-specific neuron (HSN)/phasmid neuron (PHB), acting in concert with the kinase, ham-1, and the T-box protein tbx-2 and the homeobox protein egl-5 (PubMed:3200316, PubMed:18505863, PubMed:8951066, PubMed:28659600, PubMed:23946438).
messages: cell cortex

6239:CELE T07H3.4
gene id: 6239:CELE_T07H3.4
uniprot id: O76608
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y54G2A.17
gene id: 6239:CELE_Y54G2A.17
uniprot id: Q95XX1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activity is highest with Mn(2+).
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

6239:CELE ZC376.7
gene id: 6239:CELE_ZC376.7
uniprot id: Q23272
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR) (PubMed:22700657, PubMed:25274306, PubMed:25773600, PubMed:30642431). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity (PubMed:22700657, PubMed:25274306, PubMed:25773600). Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of chaperone and assembly factor genes (PubMed:25773600). Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707). Acts together with flp-7 to negatively regulate the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress (PubMed:33078707). In addition, functions with hlh-11 to maintain lifespan (PubMed:33078707). Promotes mtDNA maintenance and propagation of deleterious mtDNA (PubMed:27135930).
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Induced by mitochondrial stress.
messages: May be desumoylated by ulp-4.
messages: Mitochondrion matrix
messages: Nucleus
messages: Prevents the up-regulation of several innate immune genes following P.aeruginosa-mediated infection (PubMed:25274306). RNAi-mediated knockdown causes a reduction in survival following P.aeruginosa-mediated infection (PubMed:25274306). Prevents the up-regulation of mitochondrial protective genes and increases the transcription of oxidative phosphorylation machinery and tricarboxylic acid cycle genes following mitochondrial stress caused by RNAi-mediated knockdown of protease spg-7 (PubMed:22700657, PubMed:25773600). Assembly of complex I and ATP synthase of the oxidative phosphorylation machinery and oxygen consumption are reduced in a spg-7 RNAi-mediated background (PubMed:25773600). RNAi-mediated knockdown reduces the levels of deleterious mtDNA that occurs in aging cells (PubMed:27135930). Protection from death following anoxia-reperfusion is lost in a spg-7 RNAi-mediated background (PubMed:27459203). RNAi-mediated knockdown does not alter atgl-1 expression (PubMed:33078707). However, RNAi-mediated knockdown increases atgl-1 expression in a hlh-11 ok2944 mutant background (PubMed:33078707). RNAi-mediated knockdown reduces the induction of hsp-60, an indicator of mitochondrial stress following overexpression of flp-7 (PubMed:33078707).
messages: Ubiquitously expressed.

6239:CELE Y39A3CR.1
gene id: 6239:CELE_Y39A3CR.1
uniprot id: Q9N405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

6239:CELE W02F12.7
gene id: 6239:CELE_W02F12.7
uniprot id: O45150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F35C8.6
gene id: 6239:CELE_F35C8.6
uniprot id: Q20025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
messages: Expressed in the intestinal wall, the spermatheca, and the pharynx.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

6239:CELE T13B5.4
gene id: 6239:CELE_T13B5.4
uniprot id: P34804
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE F23D12.5
gene id: 6239:CELE_F23D12.5
uniprot id: Q19760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

6239:CELE F48A11.1
gene id: 6239:CELE_F48A11.1
uniprot id: A0A0K3AR16
uniprot id: G5EBQ8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family. Class IV subfamily.
messages: Cell membrane
messages: May be involved in chitin synthesis in the pharynx during larval development.
messages: Membrane
messages: RNAi-mediated knockdown causes a severe delay in larval development with most animals arrested at the L1 larval stage (PubMed:16098962, PubMed:15777697). Arrested larvae have a disorganized and larger pharynx grinder probably causing feeding defects and thus a delayed growth (PubMed:16098962).
messages: Specifically expressed just prior to each larval molt (PubMed:11589574). Expression is restricted to the pharynx and specifically to the glandular cells g1 and g2 in the terminal bulb, the 3 m4 myo-epithelial cells in the metacorpus and the 3 m3 myo-epithelial cells in the procorpus (PubMed:16098962, PubMed:11589574). Not expressed in adults (PubMed:11589574).

6239:CELE F25G6.7
gene id: 6239:CELE_F25G6.7
uniprot id: H2KYN8
uniprot id: Q6A592
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F09G2.6
gene id: 6239:CELE_F09G2.6
uniprot id: O17401
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0464.4
gene id: 6239:CELE_B0464.4
uniprot id: Q03562
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Cytoplasm
messages: Endothelial cells.
messages: Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis (PubMed:12944392, PubMed:10924467). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-4 and bre-5 (PubMed:12944392, PubMed:10924467). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796). Has a role in determining brood size (PubMed:12944392, PubMed:10924467).
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 17% of wild-type N2.

6239:CELE Y59E9AR.7
gene id: 6239:CELE_Y59E9AR.7
uniprot id: G5EBJ8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y38A10A.1
gene id: 6239:CELE_Y38A10A.1
uniprot id: Q9UAX5
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F21F3.2
gene id: 6239:CELE_F21F3.2
uniprot id: P91267
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE C41C4.6
gene id: 6239:CELE_C41C4.6
uniprot id: Q09275
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals are viable, but sterile and display phenotypes including an increased lifespan, age-dependent decline in their pharyngeal pumping rate and locomotion, reduced body fat and decreased oxygen consumption and an impaired ability to maintain mitochondrial membrane potential (PubMed:25187565). RNAi-mediated knockdown causes a number of defects during the first embryonic mitotic division including delayed spindle rotation, diminished spindle pole separation, two-fold faster chromosomal segregation, increased distance between chromosomes after anaphase onset, delayed mitotic exit, less efficient removal of smo-1 from chromatin after anaphase onset and prevention of air-2 from localizing to the spindle midzone (PubMed:25475837). RNAi-mediated knockdown results in increased sumoylation of hmgs-1 (PubMed:25187565). RNAi-mediated knockdown prevents dve-1 translocation to the nucleus in response to mitochondrial stress (PubMed:30642431). RNAi-mediated knockdown reduces the levels of afts-1, but levels are restored following inhibition of the proteasome (PubMed:30642431). RNAi-mediated knockdown reduces the survival of animals and results in impaired activation of the mitochondrial unfolded protein response following the inhibition of respiration induced by antimycin A (PubMed:30642431). RNAi-mediated knockdown impairs development and survival, and reduces the expression of immune response genes lys-2, zip-2, clec-4, clec-65 and ugt-61 following infection with P.aeruginosa (PubMed:30642431).
messages: Belongs to the peptidase C48 family.
messages: Cytoplasm
messages: Expressed in hermaphrodite-specific neurons, head muscles, body wall muscles and pharyngeal cells.
messages: First expressed in body wall muscles and hypodermal cells during embryonic development to adulthood. Expressed in the pharynx and hypodermis from larval stages L1 to L3. Expressed in hermaphrodite-specific neurons from the L4 stage of larval development.
messages: Mitochondrion matrix
messages: Nucleus
messages: Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression (PubMed:25475837) (Probable). Required for respiration and the maintenance of normal mitochondrial homeostasis (PubMed:25187565). In response to mitochondrial stress, required for the removal of smo-1 conjugates from the transcription factor dve-1, which promotes the translocation of dve-1 from the cytosol to the nucleus to initiate the mitochondrial unfolded protein response (PubMed:30642431). Furthermore, removes the smo-1 conjugates from the transcription factor atfs-1 to promote its stability and activate the mitochondrial unfolded protein response (PubMed:30642431). Also plays a role in promoting mitochondrial unfolded protein response-mediated innate immunity following infection with P.aeruginosa (PubMed:30642431).
messages: Up-regulated in response to mitochondrial stress induced by antimycin A.
messages: centrosome

6239:CELE Y47H9C.5
gene id: 6239:CELE_Y47H9C.5
uniprot id: Q9XWE1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

6239:CELE C30C11.2
gene id: 6239:CELE_C30C11.2
uniprot id: Q04908
names: Function
names: Similarity
names: Subunit
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S3 family.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).

6239:CELE ZK1225.2
gene id: 6239:CELE_ZK1225.2
uniprot id: Q9XXL2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y57G11C.10
gene id: 6239:CELE_Y57G11C.10
uniprot id: E9P8A8
uniprot id: G5EBR1
uniprot id: Q2V4S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

6239:CELE F14D12.2
gene id: 6239:CELE_F14D12.2
uniprot id: P50464
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Probably function in adherens junction (PubMed:12808046). Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons (PubMed:12808046).
messages: Interacts with unc-98 (PubMed:12808046). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: Nucleus
messages: RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle. This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization.
messages: Restricted to tissue types that attach to the hypodermis, specifically body wall muscles, vulval muscles, and mechanosensory neurons.
messages: adherens junction

6239:CELE T15D6.5
gene id: 6239:CELE_T15D6.5
uniprot id: Q9XU74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C14B9.7
gene id: 6239:CELE_C14B9.7
uniprot id: P34334
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

6239:CELE K06C4.12
gene id: 6239:CELE_K06C4.12
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T15D6.3
gene id: 6239:CELE_T15D6.3
uniprot id: O02315
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE W04A4.4
gene id: 6239:CELE_W04A4.4
uniprot id: O18165
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55F8.5
gene id: 6239:CELE_F55F8.5
uniprot id: P91343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

6239:CELE F58H1.4
gene id: 6239:CELE_F58H1.4
uniprot id: C8KHX6
uniprot id: Q21013
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of burs and pburs.
messages: Secreted

6239:CELE K06A4.5
gene id: 6239:CELE_K06A4.5
uniprot id: Q19341
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

6239:CELE T22A3.2
gene id: 6239:CELE_T22A3.2
uniprot id: G5EE65
uniprot id: O01263
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE R11E3.8
gene id: 6239:CELE_R11E3.8
uniprot id: Q9TYX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE T05B4.8
gene id: 6239:CELE_T05B4.8
uniprot id: O16417
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55A12.8
gene id: 6239:CELE_F55A12.8
uniprot id: O01757
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
messages: nucleolus

6239:CELE B0511.13
gene id: 6239:CELE_B0511.13
uniprot id: Q95X35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

6239:CELE C54E10.5
gene id: 6239:CELE_C54E10.5
uniprot id: O45315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE M04F3.1
gene id: 6239:CELE_M04F3.1
uniprot id: Q95Y97
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

6239:CELE F57B9.8
gene id: 6239:CELE_F57B9.8
uniprot id: Q20933
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C52D10.8
gene id: 6239:CELE_C52D10.8
uniprot id: G5EEX4
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE T27B7.2
gene id: 6239:CELE_T27B7.2
uniprot id: O16663
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C43E11.7
gene id: 6239:CELE_C43E11.7
uniprot id: P91148
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

6239:CELE W01C9.4
gene id: 6239:CELE_W01C9.4
uniprot id: Q23116
names: Function
names: Similarity
messages: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE C06G3.1
gene id: 6239:CELE_C06G3.1
uniprot id: Q3LQX0
uniprot id: Q86PJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y67D8C.5
gene id: 6239:CELE_Y67D8C.5
uniprot id: Q9GUP2
uniprot id: U4PBJ5
uniprot id: U4PBK1
uniprot id: U4PBX5
uniprot id: U4PBY0
uniprot id: U4PES6
uniprot id: U4PMD1
uniprot id: U4PRN6
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

6239:CELE Y39B6A.36
gene id: 6239:CELE_Y39B6A.36
uniprot id: Q8MYM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

6239:CELE F56F3.6
gene id: 6239:CELE_F56F3.6
uniprot id: G5EFH1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 33% reduction in the larval diapause in the presence of dauer pheromone compared to wild-type.
messages: Belongs to the insulin family.
messages: Expressed during larval and adult stages with the highest expression during the L2 stage of larval development (PubMed:14730154). Expressed in head neurons at pre-dauer, dauer and post-dauer larval stages (PubMed:23132577). During the dauer stage, also expressed in tail neurons, amphid neurons, the ventral nerve cord and AVG interneurons (PubMed:23132577).
messages: Expressed in head neurons and the uterus.
messages: Involved in the regulation of the larval diapause.
messages: Secreted

6239:CELE K04E7.2
gene id: 6239:CELE_K04E7.2
uniprot id: Q21219
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Biphasic expression pattern observed. Gradual increase in expression during development from embryo through to adult with a decrease during larva stages 1 and 2.
messages: Expressed specifically in the intestine.
messages: Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism. It is required for the uptake of the L-enantiomers of various amino acids, including L-glutamate (PubMed:30560135). In response to the availability of amino acid nutrients, may play a role in promoting reproduction and fertility (PubMed:30560135).
messages: Mutant worms have decreased body size, high fat stores, increased uptake of fatty acids, reduced brood size, retarded postembryonic growth, extended reproductive life span and increased resistance to stress. RNAi-mediated knockdown of the protein results in impaired synthesis of long-chain and polyunsaturated fatty acids. Pharyngeal pumping rate is similar to wild type but simultaneous knockdown with nhx-2 results in reduced rate of pharyngeal pumping and slightly higher acidic intestinal pH.

6239:CELE F30H5.1
gene id: 6239:CELE_F30H5.1
uniprot id: G5EG62
names: Subcellular Location Annotation
messages: perinuclear region

6239:CELE R05A10.6
gene id: 6239:CELE_R05A10.6
uniprot id: O45703
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE M02H5.6
gene id: 6239:CELE_M02H5.6
uniprot id: A0A0K3ASR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y73B6BL.5
gene id: 6239:CELE_Y73B6BL.5
uniprot id: A9D2P7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all nuclei in the early embryo until the comma stage, and then is expressed in body wall muscle cells and pharynx in the embryo (PubMed:17716643). Expressed in muscle until the late larval stages (PubMed:17716643). In larvae, highly expressed in intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca (PubMed:17716643). In L3 stage larvae, expressed at low levels in distal tip cells during the ventral-to-dorsal second and longitudinal third migration phases, but not expressed during the first migration phase (PubMed:17716643). In L4 stage larvae, expressed at low levels in the ventral nerve cord (PubMed:17716643).
messages: Highly expressed in intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca (PubMed:17716643). Expressed at low levels in the ventral nerve cord (PubMed:17716643).
messages: Nucleus
messages: Together with unc-5, involved in touch neuron axon guidance (PubMed:9473333). During gonad morphogenesis, plays a role in the unc-5-/unc-6-mediated migration of distal tip cells along the body (PubMed:17716643).

6239:CELE F19H8.1
gene id: 6239:CELE_F19H8.1
uniprot id: O45380
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
messages: Expressed in all development stages.
messages: In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: No visible phenotype.

6239:CELE ZK1248.2
gene id: 6239:CELE_ZK1248.2
uniprot id: Q23422
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C02C2.3
gene id: 6239:CELE_C02C2.3
uniprot id: P34271
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cytoplasmic vesicle membrane
messages: Expressed in coelomocytes.
messages: Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor.
messages: Worms display a lack of uptake of GFP from the pseudocoelom into coelomocytes, suggesting a decrease or absence of endocytosis in coelomocytes. Mutants also display a slightly dumpy appearance with a low penetrance defect in distal tip cell leader function, indicating defects in coelomocyte function.

6239:CELE Y113G7A.8
gene id: 6239:CELE_Y113G7A.8
uniprot id: G5EGH9
uniprot id: M1ZMI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.

6239:CELE F44E2.6
gene id: 6239:CELE_F44E2.6
uniprot id: Q1W0S5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

6239:CELE Y37D8A.17
gene id: 6239:CELE_Y37D8A.17
uniprot id: A0A1N7SYQ5
uniprot id: A0A1N7SYR4
uniprot id: Q9XWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

6239:CELE F08F1.9
gene id: 6239:CELE_F08F1.9
uniprot id: O17384
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE K11B4.2
gene id: 6239:CELE_K11B4.2
uniprot id: O45685
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.

6239:CELE Y17G7B.18
gene id: 6239:CELE_Y17G7B.18
uniprot id: Q9U2R0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Probable RNA methyltransferase.

6239:CELE C07A9.7
gene id: 6239:CELE_C07A9.7
uniprot id: P34318
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.

6239:CELE F32A11.6
gene id: 6239:CELE_F32A11.6
uniprot id: Q9XV46
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Exclusively expressed in the hermaphrodite gonad. Weakly distributed throughout gonadal oocytes from the mitotic stage to the developing diakinesis stage, with expression restricted to the distal region of the gonad.
messages: In adult hermaphrodites, double RNAi-mediated knockdown with oma-1 results in a 20% reduction in number of eggs laid. Triple RNAi-mediated knockdown with oma-1 and oma-2 results in a 85% reduction in number of eggs laid.
messages: Zinc-finger protein that may play a role in oocyte maturation and fertility.

6239:CELE W09C5.2
gene id: 6239:CELE_W09C5.2
uniprot id: Q9U334
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

6239:CELE C15H9.1
gene id: 6239:CELE_C15H9.1
uniprot id: Q18031
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

6239:CELE F31B9.1
gene id: 6239:CELE_F31B9.1
uniprot id: O62189
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C15H11.9
gene id: 6239:CELE_C15H11.9
uniprot id: Q9XVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: nucleolus

6239:CELE C39H7.7
gene id: 6239:CELE_C39H7.7
uniprot id: Q95ZX2
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F54C1.1
gene id: 6239:CELE_F54C1.1
uniprot id: P91326
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0361.8
gene id: 6239:CELE_B0361.8
uniprot id: P53993
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.

6239:CELE T14F9.5
gene id: 6239:CELE_T14F9.5
uniprot id: Q10574
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in PVD motor neurons.
messages: Expressed in V5 postdeirid lineage cells in L2 larvae (PubMed:31386623). Expressed in the nine ray lineage Rn.a neuroblasts and their progeny, Rn.aa and Rn.ap (PubMed:11076762).
messages: Forms a heterodimer with hlh-2.
messages: Knockout results in ectopic AMsh glial cells and also ectopic amphid socket (AMso) cells, another type of glia, from a different cell lineage (PubMed:32665354). Some animals are missing dorsal, but not ventral, CEPsh glial cells (PubMed:32665354). Mean number of ectopic AMsh glial cells increases on cnd-1 or ngn-1 mutant backgrounds (PubMed:32665354).
messages: Nucleus
messages: Probable transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:11076762). Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs (PubMed:7800042). Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis (PubMed:31386623). Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:11076762). Involved in regulating glial specification, perhaps by suppressing a glial fate in different lineages during early embryogenesis (PubMed:32665354).

6239:CELE C34D4.13
gene id: 6239:CELE_C34D4.13
uniprot id: Q18446
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE C31E10.5
gene id: 6239:CELE_C31E10.5
uniprot id: Q93309
names: Similarity
messages: Belongs to the CCDC93 family.

6239:CELE ZK488.9
gene id: 6239:CELE_ZK488.9
uniprot id: O17023
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y19D10A.4
gene id: 6239:CELE_Y19D10A.4
uniprot id: A0A0M7RFG7
uniprot id: G5EDZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T08G11.5
gene id: 6239:CELE_T08G11.5
uniprot id: P48181
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Interacts with lev-1 (PubMed:15990870). Component of nicotinic acetylcholine receptor composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8 (PubMed:15990870). Interacts with oig-4 (PubMed:21252855). Interacts with crld-1 (PubMed:30407909).
messages: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis and small impairment in mobility.

6239:CELE Y80D3A.3
gene id: 6239:CELE_Y80D3A.3
uniprot id: Q9U1R1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Expressed in the early embryo, in the mesodermal lineage derived from the MS blastomere.
messages: Nucleus
messages: RNAi-mediated knockdown on an hlh-1 mutant background causes embryos to become paralyzed and arrested at the 2-fold stage.
messages: Required for mesoderm development, including specification of muscle and coelomocyte precursors.

6239:CELE F56D5.1
gene id: 6239:CELE_F56D5.1
uniprot id: Q20880
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C14F5.1
gene id: 6239:CELE_C14F5.1
uniprot id: Q09969
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NIP3 family.
messages: Expressed in all somatic tissues including neurons, pharynx, intestine, body wall muscles and vulva muscles.
messages: Expressed in the embryo and throughout all stages of development to adulthood.
messages: Homodimer; via transmembrane domain (PubMed:11114722, PubMed:9824163). Interacts with ced-3 and ced-9 (PubMed:9824163).
messages: Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes (PubMed:11114722). Has a role in lifespan and tumor growth (PubMed:16380712, PubMed:17934462). Required for the induction of mitophagy under stress conditions (PubMed:25896323).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown causes an increased sensitivity to stress and inhibits mitophagy which leads to an accumulation of defective mitochondria that have increased mass, altered network morphology, decreased ATP levels, increased reactive oxygen species (ROS) generation, membrane depolarization, increased oxygen consumption and increased cytoplasmic Ca(2+) that intensifies under stress conditions. RNAi-mediated knockdown in daf-2, isp-1, or clk-1 mutant backgrounds suppresses their increased lifespan phenotype.
messages: Ubiquitinated and degraded by the proteasome (PubMed:11114722). Under oxidative stress conditions, ubiquitinated at Lys-26 in a pink-1 dependent manner. Colocalizes with pdr-1 and may be ubiquitinated by it (PubMed:25896323).

6239:CELE F13H10.2
gene id: 6239:CELE_F13H10.2
uniprot id: Q19427
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Binds 3 Mg(2+) or Mn(2+) ions per subunit.
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives (PubMed:10873676).

6239:CELE T14B1.2
gene id: 6239:CELE_T14B1.2
uniprot id: G5ECD9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the intestinal muscle, anal depressor, AVL and DVB GABAergic neurons, enteric muscles, the nerve ring, the ventral nerve cord and head mesodermal cells.
messages: G-protein coupled receptor for the nlp-40 neuropeptide (PubMed:23583549). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23583549). Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds (PubMed:18852466, PubMed:23583549). Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation (PubMed:18852466, PubMed:23583549). Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine (PubMed:25849533).
messages: RNAi-mediated knockdown results in a mild defecation defect.
messages: cilium

6239:CELE F10B5.5
gene id: 6239:CELE_F10B5.5
uniprot id: Q09535
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Plays a key role in chromosome recombination during meiosis.

6239:CELE F59A6.3
gene id: 6239:CELE_F59A6.3
uniprot id: Q21027
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y54E10A.7
gene id: 6239:CELE_Y54E10A.7
uniprot id: Q9N3F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

6239:CELE F35C5.2
gene id: 6239:CELE_F35C5.2
uniprot id: Q9XVP3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C11E4.3
gene id: 6239:CELE_C11E4.3
uniprot id: Q93205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C47F8.4
gene id: 6239:CELE_C47F8.4
uniprot id: O62113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE T28F4.2
gene id: 6239:CELE_T28F4.2
uniprot id: Q22851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F01F1.2
gene id: 6239:CELE_F01F1.2
uniprot id: Q19093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

6239:CELE F37C12.3
gene id: 6239:CELE_F37C12.3
uniprot id: Q20122
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

6239:CELE R05H5.6
gene id: 6239:CELE_R05H5.6
uniprot id: P54141
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed in the ADL, ADF and ASH chemosensory neurons in the head and in the PHA and PHB chemosensory neurons in the tail. Low expression also observed in the egg-laying structures in the mid-body region.
messages: Mediates recognition and avoidance of Streptomyces species by detecting dodecanoic acid secreted by the bacteria. Also mediates avoidance of decanoic acid which is not secreted by Streptomyces species but this may represent an additional important avoidance response in the environment.
messages: RNAi-mediated knockdown results in defective head and tail avoidance responses to Streptomyces and to dodecanoic acid. It also results in severely reduced calcium influx into ASH neurons in response to both S.avermitilis and dodecanoic acid.

6239:CELE Y71H2AM.11
gene id: 6239:CELE_Y71H2AM.11
uniprot id: Q9BL46
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

6239:CELE K10B2.4
gene id: 6239:CELE_K10B2.4
uniprot id: Q09993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asterix family.
messages: Membrane

6239:CELE C06E8.5
gene id: 6239:CELE_C06E8.5
uniprot id: Q17738
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE F26A3.1
gene id: 6239:CELE_F26A3.1
uniprot id: Q93595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

6239:CELE Y73F8A.2
gene id: 6239:CELE_Y73F8A.2
uniprot id: Q9NA62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y87G2A.19
gene id: 6239:CELE_Y87G2A.19
uniprot id: Q56VY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE R01E6.2
gene id: 6239:CELE_R01E6.2
uniprot id: Q21619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I33 family.
messages: Secreted

6239:CELE Y48C3A.17
gene id: 6239:CELE_Y48C3A.17
uniprot id: A5HWA8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus
messages: Reduced level of constitutive germ cell apoptosis on a ced-6 mutant background, in hermaphrodites (PubMed:17881492). Blocks DNA damage-induced germ cell apoptosis, but does not affect associated cell-cycle arrest (PubMed:17881492).
messages: Transcription activator (By similarity). May activate expression of the pro-apoptotic genes ced-4 and ced-3 (PubMed:17881492). Required for constitutive, and for DNA damage-induced, programmed cell death of germ cells (PubMed:17881492).

6239:CELE K07C11.1
gene id: 6239:CELE_K07C11.1
uniprot id: Q21272
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in 14 pharyngeal cells, which include nine marginal cells, the e2 epithelial cells and the pm8 muscle (PubMed:20714352). Earliest expression in marginal cells is shortly after embryonic cell division ceases, at the late-bean to early-comma stages of development (PubMed:20714352). Expression in these cells diminishes during later embryogenesis and is absent in larvae and adults (PubMed:20714352).
messages: Nucleus
messages: Transcription factor (By similarity). May play a role in pharyngeal cell differentiation (Probable). May have a protective role in response to infection by the Gram-negative bacterium Vibrio cholerae (PubMed:22675448).

6239:CELE ZK973.5
gene id: 6239:CELE_ZK973.5
uniprot id: Q9N4M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE C01G10.9
gene id: 6239:CELE_C01G10.9
uniprot id: Q93169
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

6239:CELE C18C4.10
gene id: 6239:CELE_C18C4.10
uniprot id: P46822
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Cytoplasm
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells (PubMed:19605495, PubMed:27697906).
messages: Nucleus envelope
messages: Oligomeric complex composed of two heavy chains and two light chains (Probable). Interacts with unc-83; the interaction is direct (PubMed:19605495). Interacts with unc-33; the interaction regulates unc-33 neurite localization (PubMed:16236031). Interacts with casy-1 (PubMed:25035490).
messages: RNAi-mediated knockdown results in defects in nuclear migration in hyp7 hypodermal precursor cells (PubMed:27697906). RNAi-mediated knockdown in a dhc-1 (js319) mutant background results in defective nuclei migrations in larval hypodermal P-cells (PubMed:27697906).
messages: The light chain is composed of three structural domains: a large globular N-terminal domain which may be involved in binding to kinesin heavy chains, a central alpha-helical coiled-coil domain that mediates the light chain dimerization; and a small globular C-terminal which may play a role in regulating mechanochemical activity or attachment of kinesin to membrane-bound organelles.
messages: cytoskeleton

6239:CELE R11G11.13
gene id: 6239:CELE_R11G11.13
uniprot id: O16955
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F33D11.3
gene id: 6239:CELE_F33D11.3
uniprot id: O44774
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y62E10A.15
gene id: 6239:CELE_Y62E10A.15
uniprot id: I2HAA9
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F37C12.4
gene id: 6239:CELE_F37C12.4
uniprot id: P49181
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Cytoplasm
messages: cytosol

6239:CELE R07H5.3
gene id: 6239:CELE_R07H5.3
uniprot id: B2MZC3
uniprot id: Q93931
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

6239:CELE T23G11.3
gene id: 6239:CELE_T23G11.3
uniprot id: Q17339
names: Domain
names: Function
names: PTM
names: Subunit
names: Tissue Specificity
messages: Expressed in proximal and distal oocytes in female worms but is eliminated from proximal oocytes following mating.
messages: Homodimer.
messages: Phosphorylated by cdk-2 which may negatively regulate its expression in distal mitotic germline cells.
messages: RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence (PubMed:24838563). Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA (PubMed:11562350). Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA (PubMed:19758560). Binds sequences in the 3'-UTR region of tra-2 mRNA (PubMed:24838563). Binds to the 3' UTR of Notch receptor homolog glp-1, thereby repressing glp-1 translation in the embryo (PubMed:7601353). Binding to the glp-1 3' UTR is inhibited by pos-1 binding to an overlapping binding site in the glp-1 3' UTR (PubMed:7601353). Germ line-specific tumor suppressor essential for oogenesis (PubMed:7601353). Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline (PubMed:7601353, PubMed:11562350, PubMed:24838563). Represses translation of the vacuolar ATPase component vha-13 in the distal gonad (PubMed:29168500). Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation (PubMed:11562350). By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells (PubMed:19758560, PubMed:21455289).
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Undergoes proteasomal degradation in proximal oocytes following mating.

6239:CELE C54D10.4
gene id: 6239:CELE_C54D10.4
uniprot id: Q18833
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K09H9.3
gene id: 6239:CELE_K09H9.3
uniprot id: O44989
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Expressed in the hypodermal cells of the tail and head, the seam cells, and in the hyp7 syncytial hypodermis in the larval L4 stage, and in the young adult (PubMed:24569038, PubMed:29604168). Not expressed in the cells of the developing vulva (PubMed:24569038).
messages: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle (PubMed:24569038).
messages: RNAi-mediated knockdown causes dumpy body shape (PubMed:24569038). Defects in cuticle integrity (PubMed:24569038).

6239:CELE C47C12.6
gene id: 6239:CELE_C47C12.6
uniprot id: P24585
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane
messages: Probable sodium channel subunit. Required by a subset of neurons.

6239:CELE R06C7.1
gene id: 6239:CELE_R06C7.1
uniprot id: Q21770
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.
messages: Belongs to the Argonaute family. WAGO subfamily.
messages: Cytoplasmic granule
messages: Enriched in sperm and oocytes.
messages: Interacts with rde-12 (PubMed:24684931). Interacts with znfx-1 (PubMed:29775580).
messages: Members of the WAGO (worm-specific argonaute) subfamily lack conserved metal-binding residues found in other argonaute proteins and probably do not cleave target mRNAs directly.

6239:CELE W05H5.7
gene id: 6239:CELE_W05H5.7
uniprot id: P90837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE B0513.2
gene id: 6239:CELE_B0513.2
uniprot id: Q9U3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus

6239:CELE T20H4.4
gene id: 6239:CELE_T20H4.4
uniprot id: Q22618
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Can prevent somatic transgenes from inducing gene silencing via the RNA interference (RNAi) pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.
messages: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Acts primarily on non-coding regions of protein-coding genes including introns and untranslated regions (UTR) (PubMed:28925356, PubMed:25373143). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis (PubMed:28925356). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).
messages: Cytoplasm
messages: Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood.
messages: Interacts with A-to-I RNA editing regulator adr-1 (PubMed:24508457). Interacts with adbp-1; the interaction facilitates adr-2 nuclear localization (PubMed:18780728).
messages: Nucleus

6239:CELE Y55F3BL.6
gene id: 6239:CELE_Y55F3BL.6
uniprot id: U4PMP9
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE Y53F4B.13
gene id: 6239:CELE_Y53F4B.13
uniprot id: Q9NAA5
names: Function
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation.

6239:CELE F08A8.2
gene id: 6239:CELE_F08A8.2
uniprot id: O62137
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ATP (PubMed:27551084). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (PubMed:27551084). ATP binding likely occurs during acox-1.2 folding and/or dimer formation (PubMed:27551084). The preference for processing substrates with shorter fatty acid chains is likely due to the closed conformation of the active site (PubMed:27551084).
messages: Belongs to the acyl-CoA oxidase family.
messages: Homodimer (Probable) (PubMed:27551084). Forms a heterodimer with acox-1.1 (PubMed:25775534).
messages: Induced by high temperatures (25 degrees Celsius) (PubMed:25775534). Down-regulated in dauer conditions (PubMed:25775534).
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:25775534, PubMed:27551084). Specifically, shortens ascarosides with 5-carbon omega side chain (asc-omega-C5) (PubMed:25775534, PubMed:27551084). Does not shorten indol-3-carbonyl(IC)-ascaroside with 7-carbon or 9-carbon side chains (PubMed:29863473). Does not catalyze the desaturation of fatty acids or hydroxylated fatty acids (PubMed:25775534, PubMed:27551084).
messages: Peroxisome

6239:CELE C18C4.3
gene id: 6239:CELE_C18C4.3
uniprot id: Q18081
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-glycosyltransferase family.
messages: Interacts with cmd-1 in the presence of Ca(2+).
messages: Membrane

6239:CELE Y55D5A.5
gene id: 6239:CELE_Y55D5A.5
uniprot id: A0A0K3ARZ1
uniprot id: A0A0K3AXA0
uniprot id: Q968Y9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulation of fat, pigmented intestine, increased lifespan, increased dauer formation and increased resistance to pathogens. Severe loss of function mutants display recessive early embryonic lethality (PubMed:9252323, PubMed:9790527, PubMed:11274053, PubMed:18782349, PubMed:18245374). RNAi-mediated knockdown in germline, hypodermis, intestine or in muscles causes increased lifespan (PubMed:24332851, PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant (e1942) background reduces the increased longevity of the daf-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in adults causes an increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown results in an increase in the number of muscle arm extensions (PubMed:18436204). RNAi-mediated knockdown together with tatn-1 RNAi extends the lifespan of the single daf-2 RNAi mutant (PubMed:24385923).
messages: Autophosphorylation activates the kinase activity (By similarity). Interaction with shc-1 may inhibit its activity (PubMed:18832074).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage (PubMed:9252323, PubMed:9790527, PubMed:11743719, PubMed:24332851, PubMed:28853436, PubMed:21334311, PubMed:29500338, PubMed:24385923, PubMed:22916022). Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1 (PubMed:11274053). Required for germline progenitor proliferation during larval development (PubMed:22278922). Plays a role in maintaining gonad integrity in a daf-16/FOXO-dependent manner (PubMed:22916022). Required for the response to environmental stimuli such as light, food, pheromone, and temperature (PubMed:24332851, PubMed:29500338). Negatively regulates resistance to UV and oxidative stress (PubMed:24332851). In a daf-16/FOXO-dependent manner, plays a role in regulating the response to white light (PubMed:29500338). Role in immune function and pathogen resistance (PubMed:18782349). Negatively regulates autophagy (PubMed:22560223). Regulates daf-18/PTEN protein levels (PubMed:23995781). Plays a role in controlling seam cell development during the larval stages (PubMed:21471153).
messages: Interacts with casy-1; promoting axonal localization.
messages: Membrane
messages: Required for taste avoidance learning in axons of ASER gustatory neurons.
messages: Required for taste avoidance learning in the cell body of ASER gustatory neurons.
messages: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). Interacts (via cytoplasmic domain) with shc-1 (PID domain) (PubMed:18832074). Interacts (via kinase domain) with daf-18 (via C-terminus) (PubMed:23995781).
messages: axon

6239:CELE C54F6.13
gene id: 6239:CELE_C54F6.13
uniprot id: O16452
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endomembrane system
messages: Expressed in hypodermal cells of the main body syncytium, ut1 cells of the vulva and the spermathecal junction cell.
messages: Phosphorylated.
messages: Plays a role in epithelial membrane transport processes.

6239:CELE T05E11.1
gene id: 6239:CELE_T05E11.1
uniprot id: P49041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the small ribosomal subunit (By similarity). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity).
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
messages: Cytoplasm
messages: nucleolus

6239:CELE F31C3.4
gene id: 6239:CELE_F31C3.4
uniprot id: O62192
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W02D3.2
gene id: 6239:CELE_W02D3.2
uniprot id: O01815
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Mitochondrion inner membrane

6239:CELE T27A8.2
gene id: 6239:CELE_T27A8.2
uniprot id: Q22826
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F55A12.10
gene id: 6239:CELE_F55A12.10
uniprot id: Q95R14
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in the germline.
messages: Interacts with zhp-2; the interaction is required for their chromosome association and stability.
messages: Recruited co-dependently with zhp-2 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:29521627). Together with zhp-2, promotes the accumulation of pro-crossover proteins, including zhp-3 and zhp-4, at a designated crossover site along the recombination intermediate (PubMed:29521627). Limits the number of crossover sites along a recombination intermediate by restricting the association of these pro-crossover proteins with other recombination sites during late prophase (PubMed:29521627). Also, together with zhp-2, plays a role in chromosome remodeling following crossover formation to promote two successive rounds of chromosome segregation during meiosis (PubMed:29521627).

6239:CELE C08A9.3
gene id: 6239:CELE_C08A9.3
uniprot id: D1MN44
uniprot id: H2KYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

6239:CELE F26D10.11
gene id: 6239:CELE_F26D10.11
uniprot id: Q9XVU1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F25B4.6
gene id: 6239:CELE_F25B4.6
uniprot id: P54871
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: RNAi-mediated knockdown results in sterility, slow development, reduced body size, severe paralysis and reduced pharyngeal pumping.
messages: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
messages: Ubiquitinated.

6239:CELE Y8G1A.2
gene id: 6239:CELE_Y8G1A.2
uniprot id: O44887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C44E12.3
gene id: 6239:CELE_C44E12.3
uniprot id: G5EFI2
uniprot id: H2KZB5
uniprot id: O76788
uniprot id: O76791
uniprot id: O76792
uniprot id: O76794
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y105E8B.3
gene id: 6239:CELE_Y105E8B.3
uniprot id: Q95Q34
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Expressed in pharynx (metacorpus and posterior bulbus). Expression is restricted to adult stage.
messages: RNAi-mediated knockdown causes early larval arrest. In adults, results in no obvious phenotype.
messages: Required for larval development.

6239:CELE K02A11.3
gene id: 6239:CELE_K02A11.3
uniprot id: Q21109
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENDOU family.
messages: Catalyzes RNA cleavage releasing a product with a 2',3'-cyclic phosphate at the 3'-end.
messages: Monomer.
messages: Secreted

6239:CELE F35G12.10
gene id: 6239:CELE_F35G12.10
uniprot id: Q20053
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the subunits of the catalytic subcomplexes relative to the rotary elements (Probable). Plays a role in germline development (PubMed:17223323).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown results in sterility (PubMed:17223323). RNAi-mediated knockdown does not affect the timing of hypodermal and vulval development (PubMed:17223323).
messages: Specifically expressed in the germline from the L1 larval stage.
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE T10B11.6
gene id: 6239:CELE_T10B11.6
uniprot id: Q9TZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE T28F2.7
gene id: 6239:CELE_T28F2.7
uniprot id: O01664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C07H6.3
gene id: 6239:CELE_C07H6.3
uniprot id: Q95YF0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division.
messages: No visible phenotype; due to the redundancy with cls-2 and cls-3. Simultaneous RNAi knockdown with cls-2 produces defective microtubule cortical contacts resulting in abnormal nuclear rotation, defects in maintenance of spindle length and spindle displacement. Simultaneous RNAi knockdown with cls-2 and cls-3 shows nuclear rotation defects and excessive spindle displacement.
messages: cytoskeleton

6239:CELE T11F9.6
gene id: 6239:CELE_T11F9.6
uniprot id: Q22398
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in uterine seam (utse) cell.
messages: Metalloprotease.
messages: Secreted

6239:CELE F09B12.6
gene id: 6239:CELE_F09B12.6
uniprot id: Q9NLA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Membrane
messages: Present in the intestinal cells from comma-stage embryos through the adult stage, although the intestinal expression is weaker after the L1 stage. Accumulates at the cell membrane of intestinal cells, especially the lateral membrane intervening the intestinal cells. Also detected in the muscles of the pharyngeal isthmus from the 3-fold embryonic stage, and in a pair of head neurons, which correspond to the AUA neurons, from the late L1 stage (at protein level).
messages: Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms.

6239:CELE F11G11.13
gene id: 6239:CELE_F11G11.13
uniprot id: P91251
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C04E6.10
gene id: 6239:CELE_C04E6.10
uniprot id: O01468
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE T20G5.9
gene id: 6239:CELE_T20G5.9
uniprot id: Q22615
names: Similarity
messages: Belongs to the pym family.

6239:CELE ZK488.5
gene id: 6239:CELE_ZK488.5
uniprot id: O17019
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C24B9.14
gene id: 6239:CELE_C24B9.14
uniprot id: Q86B37
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y11D7A.13
gene id: 6239:CELE_Y11D7A.13
uniprot id: Q9XWQ6
names: Developmental Stage
names: Function
messages: Expressed during late stages of embryogenesis and larval L1 stage.
messages: Probable transcription factor (PubMed:18794349). May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2 (PubMed:18794349).

6239:CELE M176.3
gene id: 6239:CELE_M176.3
uniprot id: Q21551
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal mitochondrial morphology with localized swellings and tubular extensions. Double knockout with moma-1 or immt-1 results in reduced or no brood, poor growth and withered gonads. Furthermore, in double knockouts with moma-1, the gonads contain fewer mitochondria.
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining mitochondrial morphology (PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE C14B9.6
gene id: 6239:CELE_C14B9.6
uniprot id: P34333
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the N-CoR nuclear receptor corepressors family.
messages: Expressed throughout the developmental stages with a 2-fold increase in late larval (L4) stage.
messages: In larvae, expressed in pharyngeal neurons, ventral and dorsal nerve cords, tail neurons, egg-laying neurons and egg-laying muscles. Detected in the neurons of the pharyngeal nerve ring, head neurons, tail neurons and egg-laying muscles in adults. Detected in male-specific tail ganglia and rays in males.
messages: Interacts with gex-3. Interacts (via C-terminus) with nhr-60.
messages: Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
messages: Mutant animals display a progressive defect in locomotion starting at the L2 stage, showing delayed response to prodding, irregular thrashing movements and a low pharyngeal pumping rate. Worms have shorter body length, convoluted intestine and develop gonadogenesis defects including loss of spermathecae, sterility and larval arrest at L4 stage. They also show abnormal cholinergic signaling leading to early onset of paralysis in the presence of aldicarb, an acetylcholinesterase inhibitor. RNAi-mediated knockdown results in enlargement of mitochondria in the body wall muscle. Muscle-specific knockdown shows an increased level of oxygen consumption.
messages: Nucleus

6239:CELE F11C3.3
gene id: 6239:CELE_F11C3.3
uniprot id: P02566
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Forms a complex composed of chaperone unc-45, unc-54 and ubiquitin-protein ligase ufd-2; promotes poly-ubiquitination of unfolded unc-54 (PubMed:29396393). Within the complex interacts with unc-45 (via UCS domain) and ufd-2 (PubMed:29396393). Interacts with itr-1 (via c-terminal coiled coil domain) (PubMed:12062062).
messages: Required for muscle contraction.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: Unfolded unc-54 is poly-ubiquitinated by ufd-2.
messages: Viable, but paralyzed. Double knockout with madd-3 results in lethality. Triple knockout with madd-3, and either cebp-1, dlk-1, mak-2, pmk-3 or sek-3 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant.
messages: myofibril

6239:CELE C33H5.17
gene id: 6239:CELE_C33H5.17
uniprot id: Q18418
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription repressor.

6239:CELE T25F10.3
gene id: 6239:CELE_T25F10.3
uniprot id: Q23046
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F25D1.3
gene id: 6239:CELE_F25D1.3
uniprot id: G5EDD7
names: Similarity
messages: Belongs to the IL-17 family.

6239:CELE F45E6.2
gene id: 6239:CELE_F45E6.2
uniprot id: Q20435
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Expression is repressed by micro-RNA mir-124 (at protein level).
messages: Membrane
messages: Nucleus
messages: RNAi-mediated knockdown causes lifespan extension (PubMed:25186652). Knockdown causes no obvious other phenotypes, but in an ire-1 mutant background causes sluggish movement, arrested development at the L2 larval stage, and lethality soon thereafter; larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). In combination with RNAi-mediated knockdown of xbp-1, causes lethality early in larval development (PubMed:16184190).
messages: Transcription factor (By similarity). Plays a role in the unfolded protein response (UPR), perhaps mainly during constitutive endoplasmic reticulum (ER) stress, by activating transcription of genes involved in the UPR (PubMed:16184190). Plays a role in modulating lifespan, acting by positively regulating expression of calcium-binding chaperone crt-1, thereby influencing ER calcium homeostasis (PubMed:25186652, PubMed:32905769). By activating the UPR pathway, confers adaptive protection to subsequent exposure to hypoxia (PubMed:20733002). Involved in protection against proteotoxicity, probably acting via the UPR (PubMed:31570707). Probably acts in the UPR in parallel with the ire-1-xbp-1 and pek-1 pathways (PubMed:16184190). May be regulated by endopeptidase S2P-mediated proteolytic cleavage (PubMed:16184190).

6239:CELE Y69A2AR.29
gene id: 6239:CELE_Y69A2AR.29
uniprot id: Q95XG7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator (By similarity). Regulates expression of various genes, including homeobox protein unc-42 and helix-loop-helix protein hlh-34 (PubMed:32273286). Required for embryonic viability, neuromuscular development, organization of the nerve ring and neuronal cell body location (PubMed:32273286). Regulates AIY neuron axon morphology and cell fate (PubMed:32273286). Plays a role in cell autonomously establishing a neuronal left-right asymmetry (PubMed:21041366). Involved in regulating glial specification (PubMed:32665354).
messages: Expressed in the early embryo in ABpra/p and MSpa/p cells, with weaker expression in ABar descendants (PubMed:32273286). Expressed left-right asymmetrically in the embryo, in the mother cell to the MI pharyngeal motorneuron but not the mother cell of the e3D epithelial cell (PubMed:21041366).
messages: Interacts with hlh-2; the interaction is direct.
messages: Nucleus

6239:CELE F13B10.1
gene id: 6239:CELE_F13B10.1
uniprot id: Q5I9W0
uniprot id: Q86DA5
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SARM1 family.
messages: Cytoplasm
messages: Highly expressed in hypodermis. Localizes to postsynaptic regions of axons.
messages: Homodimer (PubMed:15048112, PubMed:27671644). Interacts with rab-1, pal-1 and unc-43 (PubMed:15048112, PubMed:15625192).
messages: NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism (PubMed:27671644). In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death (PubMed:31439792). In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008). Required for both innate immune response and specification of AWC(OFF) neuron (PubMed:15048112, PubMed:15123841, PubMed:15625192). During late embryogenesis, it acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression (PubMed:15625192). Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31 (PubMed:15048112, PubMed:15123841). Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway (PubMed:15048112, PubMed:15123841, PubMed:15625192). Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1 (PubMed:21212236). Involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381). In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals (PubMed:25204677).
messages: RNAi-mediated knockdown results in reduced survival and reduced pmk-1 phosphorylation in response to the heavy metal arsenite.
messages: Regulates expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
messages: The SAM domains mediate the localization to postsynaptic regions of neurons.
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

6239:CELE K03B8.3
gene id: 6239:CELE_K03B8.3
uniprot id: Q21179
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y57G7A.9
gene id: 6239:CELE_Y57G7A.9
uniprot id: O76629
names: Similarity
messages: Belongs to the globin family.

6239:CELE Y87G2A.8
gene id: 6239:CELE_Y87G2A.8
uniprot id: Q7K707
names: Similarity
messages: Belongs to the GPI family.

6239:CELE F54F2.9
gene id: 6239:CELE_F54F2.9
uniprot id: P34454
names: Subcellular Location Annotation
messages: Nucleus membrane

6239:CELE F10E7.5
gene id: 6239:CELE_F10E7.5
uniprot id: Q19302
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

6239:CELE B0403.2
gene id: 6239:CELE_B0403.2
uniprot id: Q11076
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6239:CELE ZK616.4
gene id: 6239:CELE_ZK616.4
uniprot id: Q9N4N4
names: Similarity
messages: Belongs to the actin family.

6239:CELE K06H7.3
gene id: 6239:CELE_K06H7.3
uniprot id: P34511
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm
messages: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (By similarity). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (By similarity). Dispensable for viability and growth but is required for protection against oxidative stress and for wild-type life span (PubMed:21070972).
messages: In larval stages and in adults, expressed in intestinal cells, specific neurons in the head and the tail, and in the ventral nerve cord.
messages: Mitochondrion

6239:CELE H30A04.1
gene id: 6239:CELE_H30A04.1
uniprot id: Q9NL29
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Highly expressed in the pharynx, circumpharyngeal cells, pharyngeal-intestinal valve and a subset of neurons in larval and embryonic stages. Also moderately expressed in the lining of the intestine, coelomocytes, labial process bundles and some hypodermal cells. In adults, it is predominantly expressed in the pharynx, the pharyngeal-intenstinal valve, some circumpharyngeal cells, m3, m4 and m6 pharyngeal muscles, and IL1, OLQ, BAG and ALN neurons. Weaker expression is observed in labial process bundles, coelomocytes, the ventral hypodermal ridge, the vulval hypodermis and the sensory rays of the adult male tail.
messages: Membrane
messages: Regulates pharyngeal pumping during feeding.
messages: Worms display a reduction in pharyngeal pumping rates, body length and intestine size, as well as a prolonged egg laying period and smaller brood size.

6239:CELE C16A11.2
gene id: 6239:CELE_C16A11.2
uniprot id: H2KYD0
names: Similarity
messages: Belongs to the CCDC93 family.

6239:CELE ZK218.1
gene id: 6239:CELE_ZK218.1
uniprot id: O45998
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T07G12.5
gene id: 6239:CELE_T07G12.5
uniprot id: A0A061ACV1
uniprot id: B3GWD8
uniprot id: O18057
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K07E8.6
gene id: 6239:CELE_K07E8.6
uniprot id: H2L0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

6239:CELE T13H10.1
gene id: 6239:CELE_T13H10.1
uniprot id: G5EC46
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y51H4A.15
gene id: 6239:CELE_Y51H4A.15
uniprot id: Q2HQJ8
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

6239:CELE C42D8.3
gene id: 6239:CELE_C42D8.3
uniprot id: Q18580
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

6239:CELE R10D12.12
gene id: 6239:CELE_R10D12.12
uniprot id: P92012
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

6239:CELE F53F1.5
gene id: 6239:CELE_F53F1.5
uniprot id: P34682
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Component of the insoluble part of the cuticles.
messages: Expressed before the L1 to L2 stage molt.
messages: Secreted
messages: The small repeats A-A-P-[AVI] are also present in many proteins constituting the protective envelope of other species.
messages: Tyrosine residues can be cross-linked in vitro, leading to the formation of insoluble high molecular-weight complexes.

6239:CELE T05A8.4
gene id: 6239:CELE_T05A8.4
uniprot id: O44857
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Expressed in muscle cells, GLR cells, SMB motor neurons and AIM interneurons.
messages: Membrane
messages: Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity.
messages: Severe defect in olfactory plasticity in response to the odorants benzaldehyde, isoamylalcohol, diacetyl and pyrazine.

6239:CELE ZK899.8
gene id: 6239:CELE_ZK899.8
uniprot id: Q8MLZ5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues.
messages: Mainly expressed in gonads and vulval cells. Isoform c in expressed in pharyngeal epithelial cells and several rectal/blast cells in the tail region. Isoform f is weakly expressed in four cells symmetrically located in the vulval region. Isoform g is strongly expressed in the pharyngeal muscle cells m6 in addition to several cells in the tail region.

6239:CELE M03F8.2
gene id: 6239:CELE_M03F8.2
uniprot id: Q8MXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Golgi apparatus membrane
messages: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).

6239:CELE C35A5.5
gene id: 6239:CELE_C35A5.5
uniprot id: Q18473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE F36D1.2
gene id: 6239:CELE_F36D1.2
uniprot id: Q9XV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F32D1.1
gene id: 6239:CELE_F32D1.1
uniprot id: A0A168H4I0
uniprot id: O16299
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family.
messages: Expressed in germ cells.
messages: Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility.
messages: Hexamer.
messages: Nucleus
messages: Sterility owing to depletion of germ cells.

6239:CELE W09D12.2
gene id: 6239:CELE_W09D12.2
uniprot id: Q23228
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE K07C11.2
gene id: 6239:CELE_K07C11.2
uniprot id: G5EDL3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

6239:CELE F59E11.2
gene id: 6239:CELE_F59E11.2
uniprot id: O16764
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F26B1.4
gene id: 6239:CELE_F26B1.4
uniprot id: P91274
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C09B9.6
gene id: 6239:CELE_C09B9.6
uniprot id: Q17856
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F01D4.7
gene id: 6239:CELE_F01D4.7
uniprot id: O02241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE R13H7.2
gene id: 6239:CELE_R13H7.2
uniprot id: H2KYF9
uniprot id: V6CK32
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C01B4.8
gene id: 6239:CELE_C01B4.8
uniprot id: G5EDB5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K08A8.1
gene id: 6239:CELE_K08A8.1
uniprot id: Q21307
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:18809575, PubMed:20008556). May also have a synergistic role with sek-1 in phosphorylating pmk-1 (PubMed:15256594, PubMed:18809575). Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation (PubMed:11013217, PubMed:15116070, PubMed:18832074, PubMed:18809575). In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024). Involved in resistance to pathogenic bacteria infection (PubMed:15256594). Involved in axon regeneration after injury (PubMed:21670305).
messages: Expressed at the embryonic stage.
messages: Expressed in pharyngeal muscles, uterine endothelial cells, intestine and in neurons of ring ganglia, ventral ganglion and ganglia around anus (PubMed:11013217, PubMed:18809575). Expressed also in hypodermis and body muscles (PubMed:18809575).
messages: Interacts with shc-1; the interaction is independent of mek-1 catalytic activity, is constitutive and may facilitate mlk-1-mediated phosphorylation by bringing mlk-1 and mek-1 together.
messages: Loss of kgb-1 activation (PubMed:15116070, PubMed:20008556). Hypersensitivity to high concentrations of copper (> 50 microM) and cadmium (>5 microM) and to food starvation which is characterized by a failure for most animals to reach adulthood. The few surviving adults appear starved and are defective in egg laying and are infertile (PubMed:11013217, PubMed:15116070). In addition, have moderate susceptibility to pathogenic bacteria infection characterized by a shorter lifespan and a substantial decrease in pmk-1 phosphorylation (PubMed:15256594). In absence of stress, animals have no obvious phenotype (PubMed:11013217, PubMed:15116070).
messages: May be activated by phosphorylation at Ser-221 and Ser-225.
messages: May be phosphorylated at Ser-221 and/or Ser-225 by mlk-1.

6239:CELE C34B7.3
gene id: 6239:CELE_C34B7.3
uniprot id: P90771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Membrane

6239:CELE C18D1.2
gene id: 6239:CELE_C18D1.2
uniprot id: Q09479
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F59A2.4
gene id: 6239:CELE_F59A2.4
uniprot id: P52874
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

6239:CELE Y59E9AR.1
gene id: 6239:CELE_Y59E9AR.1
uniprot id: G5EBJ8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y80D3A.5
gene id: 6239:CELE_Y80D3A.5
uniprot id: Q9U1R5
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y32H12A.2
gene id: 6239:CELE_Y32H12A.2
uniprot id: C2BR94
uniprot id: H2L0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

6239:CELE Y74C9A.3
gene id: 6239:CELE_Y74C9A.3
uniprot id: Q9N4D9
names: Function
names: Similarity
names: Tissue Specificity
messages: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Expressed in uterine cells and PVT neurons of the tail.

6239:CELE C33G8.7
gene id: 6239:CELE_C33G8.7
uniprot id: Q18391
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE M01A10.2
gene id: 6239:CELE_M01A10.2
uniprot id: A0A0K3AR90
uniprot id: A0A0K3ATN9
uniprot id: A0A0K3AWL6
uniprot id: G5EE26
uniprot id: Q14DX2
uniprot id: Q49HI3
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

6239:CELE T02B5.3
gene id: 6239:CELE_T02B5.3
uniprot id: P92016
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE H24K24.5
gene id: 6239:CELE_H24K24.5
uniprot id: A0A0K3AS63
uniprot id: G5ED43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE F42A6.7
gene id: 6239:CELE_F42A6.7
uniprot id: Q22037
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan.
messages: telomere

6239:CELE W04G5.5
gene id: 6239:CELE_W04G5.5
uniprot id: O18170
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE K08D9.6
gene id: 6239:CELE_K08D9.6
uniprot id: Q9TXN1
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F10B5.4
gene id: 6239:CELE_F10B5.4
uniprot id: Q09306
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TUB family.
messages: Cytoplasm
messages: Expressed in ciliated sensory neurons.
messages: Has a role in fat regulation independent of daf-16 (PubMed:12529643, PubMed:16462744, PubMed:17762880). Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis (PubMed:16462744). Required for extension and growth of sensory neuronal cilia during postembryonic development, potentially via mediating signaling protein transport and localization of PI(4,5)P2 to the ciliary base (PubMed:31259686). Functions in life span control via the insulin/IGF-1 pathway (PubMed:16054097). Thought to be involved in neuronal trafficking (PubMed:15790967).
messages: Interacts with rgb-3.
messages: Twofold increase in fat content (PubMed:12529643). Extension in life span (PubMed:12529643). Defective in chemotaxis (PubMed:12529643). Reduces AWA cilia complexity and branching from the AWA periciliary membrane compartments (PCMC) (PubMed:31259686). AWB cilia are severely truncated due to elongation failure during postembryonic stages and AWC membraneous ciliary fans are significantly decreased (PubMed:31259686). Increase in localization of PtdIns(4,5)P2 and PPK-1 to the cilia base in AWB neurons (PubMed:31259686). Reduces lengths of ASH and ASI neuronal cilia (PubMed:31259686). Mislocalization of GPCR proteins to the (PCMC) in AWB sensory neurons, such as srbc-64, tax-4 and arl-13 (PubMed:31259686). Mislocalization of tax-2 to the distal dendritic ends of ASK neurons (PubMed:31259686). Decreases dpy-23 localization to the PCMC in AWB sensory neurons (PubMed:31259686).
messages: axon
messages: cilium
messages: dendrite

6239:CELE F43G9.12
gene id: 6239:CELE_F43G9.12
uniprot id: G5EBK6
uniprot id: G5ECH1
names: Similarity
messages: Belongs to the GCF family.

6239:CELE Y110A2AL.12
gene id: 6239:CELE_Y110A2AL.12
uniprot id: D6RYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

6239:CELE T18H9.7
gene id: 6239:CELE_T18H9.7
uniprot id: Q95QA3
names: Similarity
messages: Belongs to the PACS family.

6239:CELE Y51H7C.7
gene id: 6239:CELE_Y51H7C.7
uniprot id: Q9N3J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

6239:CELE Y53F4B.22
gene id: 6239:CELE_Y53F4B.22
uniprot id: Q9NA98
uniprot id: U4PR70
names: Similarity
messages: Belongs to the actin family.

6239:CELE Y62E10A.5
gene id: 6239:CELE_Y62E10A.5
uniprot id: Q2HQK2
uniprot id: Q9U1Y0
names: Similarity
messages: Belongs to the MGMT family.

6239:CELE Y65B4A.2
gene id: 6239:CELE_Y65B4A.2
uniprot id: Q9BL59
uniprot id: V6CLS8
uniprot id: V6CLX0
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE B0240.1
gene id: 6239:CELE_B0240.1
uniprot id: Q17463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

6239:CELE F54B3.3
gene id: 6239:CELE_F54B3.3
uniprot id: Q20748
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:19888333). Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages (PubMed:19888333). Regulates mitochondrial iron homeostasis (PubMed:26427876). May play an important role in mitochondrial protein synthesis (By similarity). May also participate in mitochondrial DNA replication (By similarity). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity). Plays a role in regulating the production of reactive oxygen species in response to heat stress (PubMed:22245785).
messages: Has been shown to interact (via C-terminus) with dlg-1 (via PDZ domain) (PubMed:22245785). The physiological significance of this interaction is uncertain; the dlg-1 PDZ domain is expected to be in the cytoplasm.
messages: Has been shown to interact (via C-terminus) with mics-1 (via PDZ domain) (PubMed:22245785). The physiological significance of this interaction is uncertain; the mics-1 PDZ domain is expected to be in the cytoplasm.
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown results in an increased adult lifespan (PubMed:22245785). RNAi-mediated knockdown at the L1 stage of larval development results in arrest in the majority of animals at this larval stage (PubMed:19888333). Some surviving animals arrest during the subsequent larval stages (PubMed:19888333). RNAi-mediated knockdown in young adults results in a gradual decrease in the reproduction rate over time whereby initially fewer embryos are produced as compared to wild-type animals, and eventually adults fail to reproduce (PubMed:19888333). The few embryos that are produced by the young adults are viable, but animals arrest at the L1 larval stage (PubMed:19888333). RNAi-mediated knockdown results in sufficient mitochondrial function at the L1 larval stage, and no obvious changes in mitochondrial mass (PubMed:19888333). However, RNAi-mediated knockdown results in defects in mitochondrial activity and structure characterized by reduced mitochondrial NADH-ubiquinone oxidoreductase and citrate synthase activity compared to wild-type animals at later stages of development, and a disorganized mitochondrial network with thinner mitochondria (PubMed:19888333). RNAi-mediated knockdown results in increased levels of reactive oxygen species as compared to wild-type animals at 37 degrees Celsius (PubMed:22245785). RNAi-mediated knockdown during early developmental stages and at the L3 larval stage results in increased levels of iron and heme (PubMed:26427876). RNAi-mediated knockdown in a mics-1 mutant background results in an enhanced increase in adult lifespan as compared to the single mutants and wild-type animals (PubMed:22245785).
messages: mitochondrion nucleoid

6239:CELE B0416.5
gene id: 6239:CELE_B0416.5
uniprot id: Q11073
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C09G4.2
gene id: 6239:CELE_C09G4.2
uniprot id: H2KYN1
uniprot id: H2KYN2
uniprot id: Q8MQE2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

6239:CELE T01C8.7
gene id: 6239:CELE_T01C8.7
uniprot id: P24612
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Component of a non-voltage-gated amiloride-sensitive cation channel complex (also called the degenerin channel complex) composed of at least the mec-2, mec-4, mec-6 and mec-10 subunits; the complex mediates mechanotransduction in touch cells (PubMed:12478294). Interacts with mec-2, mec-6 and mec-10 (PubMed:12478294).
messages: Expressed in AVM, ALM, PVM and PLM touch neurons.
messages: Membrane
messages: Mutations in mec-4 results in the degeneration of a small set of neurons which typically swell to several times their normal diameter before they disappear, presumably due to lysis.
messages: Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:8655580, PubMed:12478294). Negatively regulates the turning step of male mating behavior (PubMed:17611271).
messages: axon

6239:CELE C26B2.4
gene id: 6239:CELE_C26B2.4
uniprot id: Q18190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE D1044.3
gene id: 6239:CELE_D1044.3
uniprot id: P41951
names: Subcellular Location Annotation
messages: Membrane

6239:KEF34 p02
gene id: 6239:KEF34_p02
uniprot id: G5EDH4
uniprot id: P24895
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

6239:CELE ZK287.5
gene id: 6239:CELE_ZK287.5
uniprot id: Q23457
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RING-box family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
messages: Cytoplasm
messages: Expressed at high levels in eggs and adults, and at low levels in larva.
messages: It is uncertain whether Met-1 or Met-10 is the initiator.
messages: Nucleus
messages: Part of SCF complexes, which consist of a SKP1 or a SKP1-related protein, a cullin protein, and a F-box protein (By similarity). Interacts with csn-1 and csn-6.
messages: Strongly expressed in the gonads of hermaphrodite animals.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.

6239:CELE T06A1.1
gene id: 6239:CELE_T06A1.1
uniprot id: O61930
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE B0513.3
gene id: 6239:CELE_B0513.3
uniprot id: O45226
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

6239:CELE C05D9.3
gene id: 6239:CELE_C05D9.3
uniprot id: Q9GYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

6239:CELE K02C4.3
gene id: 6239:CELE_K02C4.3
uniprot id: Q09931
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE H43I07.3
gene id: 6239:CELE_H43I07.3
uniprot id: Q8WSL9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

6239:CELE C04F6.5
gene id: 6239:CELE_C04F6.5
uniprot id: Q11177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane

6239:CELE B0238.1
gene id: 6239:CELE_B0238.1
uniprot id: O16497
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE F53G12.3
gene id: 6239:CELE_F53G12.3
uniprot id: O01795
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

6239:CELE T24H7.2
gene id: 6239:CELE_T24H7.2
uniprot id: Q22758
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE T05G11.1
gene id: 6239:CELE_T05G11.1
uniprot id: G5EGQ2
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in proximal gonad.
messages: Possible transcriptional regulator (Probable). Involved in promoting segregation of chromosomes during meiosis, perhaps acting downstream of the let-60 RAS / mpk-1 MAPK signaling pathway (PubMed:17096596).
messages: Superficially wild-type, with a normal brood size, but drastic reduction in brood size when grown at a permissive temperature of 20 degrees Celsius in an mpk-1 mutant background. Double mutant mpk-1;pzf-1 shows meiotic chromosome non-disjunction, increased embryonic lethality and also an abnormal male:hermaphrodite ratio, at 23 degrees Celsius.

6239:CELE Y58A7A.6
gene id: 6239:CELE_Y58A7A.6
uniprot id: Q966A3
names: Similarity
messages: Belongs to the globin family.

6239:CELE C34G6.5
gene id: 6239:CELE_C34G6.5
uniprot id: O01493
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE T03F6.5
gene id: 6239:CELE_T03F6.5
uniprot id: Q9NDC9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871). Interacts with nud-2; the interaction is direct (PubMed:16996038).
messages: Defects lead to convulsions mimicking epilepsy, possibly due to altered neurotransmitter function (PubMed:15254012). RNAi-mediated knockdown results in arrest at the 50-100 cell stage, whereby egg and sperm pronuclei fails to migrate (PubMed:11685578). RNAi-mediated knockdown prevents the sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells, but only in a small number of animals (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity (PubMed:20599902).
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Expressed in all classes of neurons in the ventral cord (PubMed:11685578, PubMed:16996038). Expressed in the multinucleate spermathecal valves and adult seam cells (PubMed:11685578).
messages: Nucleus envelope
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division (PubMed:11685578, PubMed:15331665). Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). Required for neuronal cell differentiation (PubMed:15254012).
messages: centrosome
messages: cytoskeleton
messages: kinetochore

6239:CELE R03D7.4
gene id: 6239:CELE_R03D7.4
uniprot id: Q09413
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterotrimer of an A, B and C subunit.
messages: Nucleus
messages: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
messages: The BC-box, which mediates binding to the elongin BC complex, has the consensus [APST]-L-x(3)-C-x(3)-[AILV].

6239:CELE Y105E8A.5
gene id: 6239:CELE_Y105E8A.5
uniprot id: Q9NEZ7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:22022287, PubMed:22922713).
messages: Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head and in both phasmid neurons PHA and PHB in the tail at larval stages L1 and L2.
messages: Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements. Defective cilia structure and function.
messages: Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity). Interacts with bbs-7 and bbs-9 (PubMed:22922713).
messages: cilium
messages: cilium axoneme
messages: cilium basal body

6239:CELE T08A9.3
gene id: 6239:CELE_T08A9.3
uniprot id: O76735
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the synaptogyrin family.
messages: Expressed in a wide variety of neurons and is expressed weakly in the non-neuronal distal tip cells. A punctate pattern was observed in the ventral and dorsal nerve cords and the nerve ring. Weak expression is seen in neuronal cell bodies and commissures.
messages: Membrane

6239:CELE ZC434.9
gene id: 6239:CELE_ZC434.9
uniprot id: G3MU28
uniprot id: G3MU29
uniprot id: G3MU30
uniprot id: Q23318
uniprot id: Q7JLE3
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54F7.5
gene id: 6239:CELE_F54F7.5
uniprot id: G5EBL2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 71 percent of embryos of mutant mothers develop into sterile adults with extra body muscle cells at the restrictive temperature (25 degrees Celsius) (PubMed:7555722). Low embryonic lethality (7-8 percent) (PubMed:7555722). Loss of lin-5 and grp-1/2 enrichment at the EMS/P2 cell boundaries at the 4-cell embryonic stage (PubMed:12730122). Decrease in phosphotyrosine levels at the site of contact between P2 and EMS cells (PubMed:12110172).
messages: Belongs to the protein kinase superfamily.
messages: Cell membrane
messages: During early embryogenesis, controls asymmetric cell division and the asymmetric localization of P granules of germline precursor P2 and its descendant P3 (PubMed:7555722). Probably upstream of tyrosine kinase src-1, plays a role in endoderm development by controlling spindle orientation during EMS blastomere cell division (PubMed:12110172). Controls EMS spindle orientation probably by promoting lin-5 and gpr-1/2 enrichment at, and let-99 exclusion from the junction between P2 and EMS cells (PubMed:14534135, PubMed:12730122).
messages: Expressed at least in P2 germline cell at 4-cell stage and up to 26-cell stage embryos (PubMed:11003841, PubMed:12110172). Expressed only at L4 stage during larval development and then accumulates in adults (PubMed:11003841).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F37F2.3
gene id: 6239:CELE_F37F2.3
uniprot id: O61750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Homodimer.

6239:CELE T07D3.7
gene id: 6239:CELE_T07D3.7
uniprot id: O16720
uniprot id: Q86B39
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE C37E2.5
gene id: 6239:CELE_C37E2.5
uniprot id: A0A078BPE8
uniprot id: A0A078BPG5
uniprot id: Q93356
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons.
messages: Broadly expressed during early embryonic development. During later embryonic stages, expression is detected in AWB olfactory sensory neurons but is absent from there by early L1 larval stages. Expression in non-neuronal cells including the excretory cell and intestine is maintained through adult stages.
messages: Expression starts during embryogenesis and continues into adulthood.
messages: Nucleus
messages: The C-terminal region is required for bending of telomeric DNA.
messages: The N-terminal and homeobox regions are together sufficient to bind telomeric DNA.
messages: telomere

6239:CELE Y57G11B.97
gene id: 6239:CELE_Y57G11B.97
uniprot id: B3GWE1
uniprot id: K8ESJ6
names: Similarity
messages: Belongs to the globin family.

6239:CELE F14D12.5
gene id: 6239:CELE_F14D12.5
uniprot id: G5EDS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE C02F12.1
gene id: 6239:CELE_C02F12.1
uniprot id: Q11098
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Expressed in dopaminergic neurons, head muscles, vulva and spermatheca.
messages: In larvae, expressed in the NSM serotonergic neuron and in muscles.
messages: Protects dopaminergic neurons against oxidative stress-induced neurodegeneration (PubMed:25474638, PubMed:29346364). May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity (PubMed:25474638). Also plays a role in modulating behaviors linked to dopamine signaling (PubMed:25474638). Confers protection against oxidative stress in the whole body (PubMed:29346364).
messages: axon
messages: dendrite

6239:CELE T10B10.4
gene id: 6239:CELE_T10B10.4
uniprot id: Q22371
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

6239:CELE Y38F2AL.3
gene id: 6239:CELE_Y38F2AL.3
uniprot id: Q9XXU9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase C subunit family.
messages: Cytoplasm
messages: Expressed ubiquitously; higher levels are found in gastrointestinal and hypodermal cells, as well as H-shaped excretory cell.
messages: Membrane
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (Probable). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). Has roles in embryogenesis and ovulation (PubMed:10846178).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunits a1 unc-32, a2 vha-5 and a3 vha-6 (PubMed:11441002).
messages: Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream.
messages: Worms display embryonic lethality. When vha-11 is silenced in adults, they are able to produce eggs but egg numbers gradually decrease and worms become sterile after 24 hours. This sterility continues for about 4 days and then viable eggs are produced again.

6239:CELE C23H5.2
gene id: 6239:CELE_C23H5.2
uniprot id: Q7YZV1
names: Similarity
messages: Belongs to the globin family.

6239:CELE T06H11.1
gene id: 6239:CELE_T06H11.1
uniprot id: Q22271
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Has a role in mobility, possibly in the transport of potassium in muscles.
messages: Membrane
messages: Worms exhibit defects in mobility. Mutation causes a dumpy (dpy) phenotype thought to be due to hyper-activation of body-wall muscle. Severe mutations cause paralysis thought to be a result of fully contracted muscles.

6239:CELE Y5H2B.1
gene id: 6239:CELE_Y5H2B.1
uniprot id: Q966A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (By similarity). Required for axon regeneration after injury (PubMed:31371405).

6239:CELE Y71H10B.1
gene id: 6239:CELE_Y71H10B.1
uniprot id: Q95X21
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

6239:CELE K07C5.1
gene id: 6239:CELE_K07C5.1
uniprot id: P53489
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP2 subfamily.
messages: Component of the Arp2/3 complex, at least composed of arx-1, arx-2, arx-4 and arx-6.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). Plays a role in time-dependent memory loss and the retention of conditioned behavior over time (PubMed:24630719).
messages: RNAi-mediated knockdown suppresses the memory retention defects of the msi-1 os1 loss of function mutant.
messages: cytoskeleton

6239:CELE K03H6.1
gene id: 6239:CELE_K03H6.1
uniprot id: O45173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE T24H7.3
gene id: 6239:CELE_T24H7.3
uniprot id: Q22757
names: Similarity
messages: Belongs to the GSKIP family.

6239:CELE C45H4.2
gene id: 6239:CELE_C45H4.2
uniprot id: O44704
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F18E3.2
gene id: 6239:CELE_F18E3.2
uniprot id: Q19558
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F21A10.2
gene id: 6239:CELE_F21A10.2
uniprot id: D9PTN5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the MRF family.
messages: Constitutes a precursor of the transcription factor (PubMed:28441531). Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Highly expressed in L1 stage larvae.
messages: Homotrimer (By similarity). Interacts with myrf-1 (PubMed:28441531).
messages: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.
messages: Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity.
messages: Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecular Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.
messages: No visible phenotype. Worms show normal dorsal D (DD) GABAergic motor neurons rewiring. Worms lacking both myrf-1 and myrf-2 display defective DD neurons rewiring.
messages: Nucleus
messages: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531). Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531). Acts in complex with myrf-1 paralog (PubMed:28441531).

6239:CELE Y77E11A.15
gene id: 6239:CELE_Y77E11A.15
uniprot id: Q8MXT6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y38E10A.18
gene id: 6239:CELE_Y38E10A.18
uniprot id: Q9NAJ3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K01B6.2
gene id: 6239:CELE_K01B6.2
uniprot id: P34490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

6239:CELE F32D8.1
gene id: 6239:CELE_F32D8.1
uniprot id: Q19962
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

6239:CELE C17A2.8
gene id: 6239:CELE_C17A2.8
uniprot id: O16537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C10H11.7
gene id: 6239:CELE_C10H11.7
uniprot id: P91035
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C44C3.7
gene id: 6239:CELE_C44C3.7
uniprot id: Q8IFX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T19B4.7
gene id: 6239:CELE_T19B4.7
uniprot id: G5EF96
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Cell membrane
messages: Expressed on the surface of motile cells and pioneering axons (PubMed:8861903). Expressed at the onset of gastrulation (at about 100 minutes (min) after first cell cleavage) on the surface of all cells, and then gradually diminishes (PubMed:8861903). Highly expressed in the neurula (at about 400 min), on ventral cord motorneurons, including cell bodies and axons, undergoing axonogenesis (PubMed:8861903). Expressed in stage L1 larvae in ventral epidermoblasts as they undergo planar movements within the epithelium and in neuroblasts QL and QR and their descendants as they migrate longitudinally along the epidermis (PubMed:8861903). Expressed in L2 and later stage larvae in distal tip cells (DTCs) of hermaphrodites as they migrate along the body wall (PubMed:8861903). Expressed in the DTCs beginning at the time of the ventral-to-dorsal second migration (PubMed:11454756). Expression on the immature hermaphrodite specific neuron (HSN) is localized to the ventral surface beginning at the early L2 stage (PubMed:16520734).
messages: Fibronectin type-III 6 motif is essential for the role of unc-40 in a TGF-beta-like signaling pathway.
messages: Interacts with netrin unc-6 (PubMed:22426253, PubMed:8861903). Interacts with eva-1 (PubMed:25122090). Interacts (via fibronectin type-III domain) with drag-1 (PubMed:24004951).
messages: Receptor for netrin unc-6 required for asymmetric axon formation, axon guidance and cell migrations (PubMed:16520734, PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333). Required during axon formation, in response to unc-6, to initiate, maintain and orient asymmetric neuronal growth, and may signal via phosphoinositide 3-kinase (PI3K) (PubMed:16520734). Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333). Involved in dendritic morphogenesis; may act by localizing unc-6 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion (PubMed:22426253). Involved in the ventral-dorsal and anterior-posterior migration of gonadal distal tip cells (DTCs) along the body (PubMed:11454756). Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail (PubMed:24004945). Positively modulates a TGF-beta-like signaling pathway, independent of its role in unc-6 mediated axon guidance, in association with RGM drag-1 (PubMed:24004951). Mediates attraction of muscle plasma membrane extensions, known as muscle arms, towards the secreted madd-4 guidance cue, enhanced by interaction with the coreceptor eva-1 (PubMed:25122090).

6239:CELE C24B5.2
gene id: 6239:CELE_C24B5.2
uniprot id: Q8MNV0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules (PubMed:17531954, PubMed:19619244, PubMed:22561316, PubMed:18202664). Probably by regulating microtubule remodeling, plays a role in new synapse formation in GABAergic DD (Dorsal D type) neurons (PubMed:26051896).
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Expressed at all developmental stages (PubMed:17531954). Highly expressed in the embryo and expressed at lower levels in L3-L4 larvae (PubMed:17531954).
messages: Highly expressed in the embryo (PubMed:17531954). Not expressed in L3-L4 larvae (PubMed:17531954).
messages: Homohexamer (PubMed:19619244, PubMed:22561316). The homohexamer is stabilized by ATP-binding (By similarity). The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules (By similarity). Interacts (via N-terminus) with tubulin; the interaction is direct (PubMed:19619244).
messages: Lacks the conserved MIT domain, which is one of the features of the spastin family.
messages: Membrane
messages: Produced by alternative splicing and the skipping of exon 4.
messages: Produced by alternative splicing, which results in the retention of exon 4.
messages: Slow growth, reduced brood size, abnormal oogenesis and multiple vulvae (PubMed:17531954). Progressive locomotor defects, which is rescued following exposure to the drugs guanabenz, salubrinal, phenazine, or methylene blue (PubMed:26744324). Lifespan is prolonged following exposure to the drugs guanabenz, salubrinal or methylene blue, but not phenazine (PubMed:26744324). Increases numbers of centrosomal microtubules in early embryos (PubMed:17531954). Reduced neutral lipid levels in intestinal cells (PubMed:25875445). RNAi-mediated knockdown results in paralysis due to an increase in the endoplasmic reticulum stress response, which is rescued following exposure to the drugs methylene blue, guanabenz, salubrinal, or phenazine (PubMed:26744324).
messages: The MTBD (microtubule binding domain) region mediates binding to microtubules and tubulin.
messages: cytoskeleton
messages: perinuclear region

6239:CELE R12E2.12
gene id: 6239:CELE_R12E2.12
uniprot id: O61791
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

6239:CELE F44G3.9
gene id: 6239:CELE_F44G3.9
uniprot id: O45521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y67A10A.8
gene id: 6239:CELE_Y67A10A.8
uniprot id: A0A061ACE6
uniprot id: Q9U1V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE C01B12.4
gene id: 6239:CELE_C01B12.4
uniprot id: O17204
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Probable transporter.

6239:CELE ZK652.9
gene id: 6239:CELE_ZK652.9
uniprot id: P34666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

6239:CELE Y39A1B.3
gene id: 6239:CELE_Y39A1B.3
uniprot id: Q9U2M1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with meiotic and mitotic chromosomes prior to the onset of dosage compensation and with hermaphrodite X chromosomes after the onset of dosage compensation (at protein level).
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19781752, PubMed:19119011, PubMed:18198337). Within the complex, interacts with dpy-26 and smc-4 (PubMed:19781752, PubMed:19119011, PubMed:28301465). Component of the dosage compensation complex, which consist of the condensin I like components mix-1/SMC2 and dpy-27/SMC4, and the three non SMC subunits dpy-26, capg-1 and dpy-28 (PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:15557118). Within the complex, interacts with mix-1, dpy-27, dpy-26 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19119011, PubMed:28301465). Interacts with smcl-1 (PubMed:28301465).
messages: Expressed in somatic and germline tissues (at protein level).
messages: Nucleus
messages: Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners (PubMed:19119011, PubMed:19781752, PubMed:3779843, PubMed:18198337). Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:19781752, PubMed:19119011). The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex function is required for proper chromosome segregation in mitosis and meiosis (PubMed:19119011). As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, possibly by influencing higher-order chromosome structure (PubMed:18198337, PubMed:19781752). Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:3779843, PubMed:19119011, PubMed:15557118).
messages: Results in high larval lethality in hermaphrodites, and survivors exhibit a XX-specific shorter and stouter body morphology (PubMed:18198337). Higher percentage of spontaneous males through X chromosome non-disjunction (PubMed:18198337). Increased number of crossovers, redistribution of crossovers and a reduction in crossover interference in meiosis (PubMed:18198337). Increased number of rad-51 foci in early to mid-pachytene indicating double strand break formation (PubMed:18198337, PubMed:19781752). Increase in X chromosome axis length indicating aberrant chromosome structure (PubMed:19781752). RNAi-mediated knockdown results in chromosome segregation defects in mitosis (PubMed:19119011).
messages: Sumoylated. Sumoylated in the context of the dosage compensation complex but not in the condensin I complex. Sumoylation is important for assembly of the dosage compensation complex and its robust binding to the X chromosome.

6239:CELE K06A1.4
gene id: 6239:CELE_K06A1.4
uniprot id: Q09587
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R53.3
gene id: 6239:CELE_R53.3
uniprot id: Q22024
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dispensable for anchor cell (AC) invasion and for preventing AC proliferation.
messages: Expressed in the hermaphrodite-specific motor neuron (HSN) / phasmid sensory neuron B (PHB) precursor, and the phasmid sensory neuron A (PHA) in the tail at ~400 minutes embryogenesis (at protein level) (PubMed:10049362). Continues to be expressed in PHA and PHB neurons of L1 larvae (PubMed:10049362). Expressed in the HSN before and during HSN migration from the tail to the gonad primordium of the embryo and down-regulated after migration (at protein level) (PubMed:10049362). Expressed in the pre-anchor cell (AC)/pre-ventral uterine (VU) cells at early L2 and maintained in their 37 descendants at early L4 (PubMed:17215301, PubMed:32203506).
messages: Expressed in the ventral uterine (VU) cells of mid L2 larvae (Pn.p stage) and then in the anchor cell (AC) beginning in mid L3 larvae (PubMed:17573066, PubMed:32203506). Expression increases during AC invasion (PubMed:17573066).
messages: Expressed, earlier than isoform a, in the anchor cell (AC) at the Pn.p stage in mid L2 larvae (PubMed:17573066). Expression decreases during AC invasion (PubMed:17573066).
messages: No defects in anchor cell (AC) invasion or arrest in G1 seen upon RNAi-mediated knockdown.
messages: Nucleus
messages: Probable transcription factor, involved in lin-12 (Notch)-dependent anchor cell (AC) and ventral uterine (VU) precursor cell fate specification and in AC invasion (PubMed:17215301, PubMed:17573066, PubMed:32203506). Prevents AC proliferation after AC cell specification by repressing lin-12 expression (PubMed:32203506). May form a positive feedback loop, together with the transcription factor fos-1, that maintains mutual high levels of expression and so activates AC invasion (PubMed:32203506).
messages: Probable transcription factor, required for migration of the hermaphrodite-specific motor neurons (HSNs) from the tail to the gonad primordium during HSN cell differentiation (PubMed:8224840, PubMed:10049362). Required for phasmid neuron development (PubMed:8224840). Required to specify the pi-cell fate of ventral uterine precursor cell (VU) cells (PubMed:17573066).
messages: RNAi-mediated knockdown causes defects in anchor cell (AC) and ventral uterine (VU) precursor cell specification and AC invasion in the larval L3 and L4 stages (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown on a lin-12 mutant background reverses the AC-deficient phenotype (PubMed:17215301). RNAi-mediated knockdown reduces expression of zmp-1, cdh-3 and him-4 in the AC (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown reduces expression of fos-1a in the anchor cell (AC) approximately three-fold (PubMed:32203506). RNAi-mediated knockdown causes defects in vulval morphogenesis (PubMed:17573066).
messages: RNAi-mediated knockdown causes defects in anchor cell (AC) invasion, including increased CDK activity and re-entry of the AC into the cell cycle, resulting in the presence of two or more AC.
messages: The C2H2-type zinc-finger domains 1, 2 and 3 are dispensable for anchor cell (AC) invasion and preventing AC proliferation.
messages: The C2H2-type zinc-finger domains 4 and 5 may be required for anchor cell (AC) invasion and preventing AC proliferation.
messages: The positive regulatory (PR) domain is required for egl-43 protein stability but is dispensable for anchor cell (AC) invasion and preventing AC proliferation.

6239:CELE K08A8.3
gene id: 6239:CELE_K08A8.3
uniprot id: A0A131MBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

6239:CELE T25F10.2
gene id: 6239:CELE_T25F10.2
uniprot id: G5EEL5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Expressed in L4 larval stage primarily in neurons, including ventral cord neurons DA, DB, VA and VB; the lateral excretory canal associated CAN cells; and anterior neurons AVK, DVA, I5, M1, M2, M4 and M5.
messages: Expressed in embryos just prior to hatching and remains constant in most cells throughout the larval and adult stages (PubMed:9847238). Expressed by AVA command interneurons (PubMed:23019581).
messages: Homodimer; disulfide-linked (By similarity). Interacts with drag-1 (PubMed:24004951).
messages: Ligand for the serine/threonine-protein kinase receptor type-1 sma-6 which activates a TGF-beta-like signaling pathway (PubMed:24004951). Multifunctional protein that is involved in body size, male ectodermal patterning, innate immunity, lipid metabolism and neural plasticity (PubMed:10021351, PubMed:9847238, PubMed:12176330, PubMed:29162682, PubMed:23019581). Dose-dependent regulator of body size, probably influencing the sizes of some or all cells rather than their number (PubMed:10021351, PubMed:9847238, PubMed:22189608). Plays a role in patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules (PubMed:10021351, PubMed:9847238). Plays a protective role in response to infection by the Gram-negative bacterium S.marcescens, by activating expression of genes involved in innate immunity (PubMed:12176330). Regulator of lipid homeostasis, acting non cell-autonomously in the hypodermis; partly dependent on the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29162682). Required for aversive olfactory learning of pathogenic bacteria in adults (PubMed:23019581). Involved in gland cell morphology, possibly via activation of a Smad-independent TGF-beta signaling pathway (PubMed:24690231). Required to oppose the autoregulation of expression of Runt-related transcription factor rnt-1.
messages: Reduced body size (PubMed:10021351). Abnormalities in the male tail (PubMed:10021351). Disrupted aversive learning (PubMed:23019581).
messages: Secreted

6239:CELE C52D10.11
gene id: 6239:CELE_C52D10.11
uniprot id: A3QM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

6239:CELE ZK131.10
gene id: 6239:CELE_ZK131.10
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE M79.4
gene id: 6239:CELE_M79.4
uniprot id: Q9XVX1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-19 is expressed in the URX interneurons, the serotonin and acetylcholine-expressing HSN neurons, and the AIN, AWA and BAG neurons.
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides. WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Secreted

6239:CELE T15D6.12
gene id: 6239:CELE_T15D6.12
uniprot id: O02319
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F10E7.8
gene id: 6239:CELE_F10E7.8
uniprot id: A0A1D3PCL0
uniprot id: Q19300
names: Similarity
messages: Belongs to the STRIP family.

6239:CELE C04G6.5
gene id: 6239:CELE_C04G6.5
uniprot id: Q17638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE T28H11.8
gene id: 6239:CELE_T28H11.8
uniprot id: Q23063
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y38A8.3
gene id: 6239:CELE_Y38A8.3
uniprot id: A0A0S4XR45
uniprot id: A0A0S4XRS7
uniprot id: Q23238
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 64% of embryos arrest in between late gastrulation and epidermal morphogenesis with failures in embryogenesis occurring during late gastrulation, epidermal enclosure and elongation. RNAi-mediated knockdown results in arrest in 29% of embryos which display a range of embryonic abnormalities including increased bulge formation (humpback phenotype), epidermal enclosure defects where the ventral cleft fails to close during embryogenesis, impeded or inhibited ventral neuroblast cell migration and irregular cell shape and positioning. Knockdown also results in failure of the catenin-cadherin complex, specifically the cadherin protein, hmr-1 to localize to adherens junctions, but to accumulate along the basolateral membrane of the cell.
messages: Belongs to the peptidase C48 family.
messages: First expressed mid-gastrulation, at the 200-cell stage of embryogenesis with expression increasing during epidermal morphogenesis. Also expressed in epidermal cells and also in the underlying neuroblasts during embryonic development.
messages: Nucleus
messages: Protease that catalyzes two essential functions in the smo-1 pathway: processing of full-length smo-1 to their mature forms and deconjugation of smo-1 from targeted proteins (By similarity). May deconjugate smo-1 from the cadherin protein hmr-1 and plays a role in its recruitment to and the maintenance of adherens junctions (PubMed:26412237). Required for epidermal morphogenesis during embryonic development (PubMed:26412237).
messages: cytosol

6239:CELE T14G12.2
gene id: 6239:CELE_T14G12.2
uniprot id: G5EEN8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Expressed in intestinal cells.
messages: RNAi-mediated knockdown results in defecation abnormalities.
messages: t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.

6239:CELE Y47H10A.1
gene id: 6239:CELE_Y47H10A.1
uniprot id: Q9U2B2
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F46B6.7
gene id: 6239:CELE_F46B6.7
uniprot id: Q20448
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZNF277 family.
messages: By microRNA let-7; probably by direct interaction.
messages: Cytoplasm
messages: Interacts with rps-2.
messages: Probable transcription factor (By similarity). Limits the ability to tolerate cold environment or cold-warm stress (PubMed:36763670). In complex with rps-2, mediates the cold-warm shock response by promoting translocation of components of the RNA exosome from the nucleolus to nucleoplasm (PubMed:36763670).
messages: RNAi-mediated knockdown suppresses lethality and sterility caused by let-7 mutant background.

6239:CELE C01A2.5
gene id: 6239:CELE_C01A2.5
uniprot id: O02209
names: Similarity
messages: Belongs to the rtf2 family.

6239:CELE F25F8.2
gene id: 6239:CELE_F25F8.2
uniprot id: Q17328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.
messages: Cell membrane
messages: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817).
messages: Pentamer (By similarity). Homooligomer that can form functional heterooligomers with glc-1 (PubMed:7935817).
messages: Postsynaptic cell membrane

6239:CELE Y43F8A.3
gene id: 6239:CELE_Y43F8A.3
uniprot id: F0IWV1
uniprot id: Q9XWL5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

6239:CELE Y74C10AR.3
gene id: 6239:CELE_Y74C10AR.3
uniprot id: G4SRS5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T25G12.4
gene id: 6239:CELE_T25G12.4
uniprot id: Q22782
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Grinder formation defects, whereby the grinder is formed, but it is small (PubMed:23792950). Animals have a fragile cuticle phenotype, which is prone to rupturing at random positions along the body (PubMed:30665892). This phenotype is intensified in response to hypotonic shock (PubMed:30665892). Due to a compromised cuticle barrier, which increases permeability to exogenous chemicals, all animals become paralyzed in response to acetylcholine agonist tetramisole or the GABA agonist piperazine (PubMed:30665892). Resistant to infection by the bacterium M. nematophilum and does not exhibit a deformity at the anal region phenotype (also known as a dar phenotype), which is possibly indicative of cuticle glycosylation defects (PubMed:30665892). Reduces spontaneous reversal rate and mechanosensitivity (PubMed:22213799). Disrupts the localization of glr-1, and there is a decreased number of glr-1-positive puncta along the ventral cord dendrites (PubMed:22213799, PubMed:26891225). The reduced number of glr-1-positive puncta along the ventral cord dendrites phenotype is suppressed in an unc-11 e47 mutant background (PubMed:22213799). The number of glr-1-positive puncta is further reduced in a rab-6.1 RNAi-mediated knockdown in glr-1 expressing neurons (PubMed:26891225). RNAi-mediated knockdown results in delayed growth and grinder formation defects (PubMed:23792950). RNAi-mediated knockdown disrupts seam cell division and alae formation (PubMed:33826611). RNAi-mediated knockdown suppresses the seam cell division and alae formation defects in the tbc-11 ok2576 mutant (PubMed:33826611).
messages: Highly expressed in body wall muscles, pharyngeal and vulval muscles, hypodermis, intestine, the gonad, coelomocytes, and neurons, including command interneuron (at protein level) (PubMed:22213799). Highly expressed in the terminal bulb muscles (PubMed:23792950).
messages: Interacts with GARP complex component vps-52 (PubMed:21613545). Interacts (in GTP-bound form) with lin-10 (PubMed:22213799). May interact (in GTP-bound form) with eat-17 (PubMed:23792950).
messages: Perikaryon
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:22213799). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22213799). In its active GTP-bound form, acts redundantly with rab-6.1 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to the Golgi compartment (PubMed:22213799, PubMed:26891225). Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons (PubMed:22213799, PubMed:26891225). Its role in glr-1 trafficking may partly be mediated by its interaction with lin-10 and association with components of the retromer complex such as rme-8 (PubMed:22213799). Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine (PubMed:26891225). Plays a role in the epidermis to promote cuticle integrity and impermeability of the cuticle barrier to exogenous molecules (PubMed:30665892). May have a role in the glycosylation of the cuticular surface (PubMed:30665892). Required for seam cell division and alae formation (PubMed:33826611). Required for grinder formation, which is the feeding organ that breaks down food (PubMed:23792950). In contrast to rab-6.1, may play a minor role in the exocytosis of secretory vesicles (cortical granules) during the oocyte-to-embryo transition (PubMed:22992455).
messages: dendrite

6239:CELE C50A2.4
gene id: 6239:CELE_C50A2.4
uniprot id: O44138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

6239:CELE F40F8.7
gene id: 6239:CELE_F40F8.7
uniprot id: G5EFY7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in intestinal cells from larval through to adult stages (PubMed:23911329). Expressed in neurons during L1 larval stage (PubMed:29949773).
messages: Induced by paraquat, a chemical causing production of reactive oxygen species (ROS).
messages: Interacts with ceh-60.
messages: Nucleus
messages: RNAi-mediated knockdown on a daf-2 mutant background shortens lifespan substantially, by up to 45%, but does not alter lifespan on a daf-16 mutant or wild-type background (PubMed:23911329). Knockdown activates vitellogenesis on either lin-29, rict-1 or sgk-1 mutant backgrounds, but not on daf-2 mutants (PubMed:27401555). Reduced expression of metal transporter smf-3 on an nhr-14 mutant background (PubMed:27401555). Enhanced sensitivity to P.aeruginosa infection on an nhr-14 mutant background (PubMed:31532389).
messages: Zinc finger transcription factor which acts as both a transcriptional activator and repressor (PubMed:23911329, PubMed:30956009). Binds to the promoters of genes that contain the 5'-CTTATCA-3' DNA consensus sequence in their regulatory region (PubMed:23911329, PubMed:31532389). Functions downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:23911329, PubMed:27401555). Involved in normal development, lifespan, stress response, lipid metabolism, innate immunity and exit from the developmentally arrested larval state known as dauer (PubMed:23911329, PubMed:27401555, PubMed:29949773, PubMed:31532389, PubMed:33009389). Required for stress-induced expression of hsp-90 and resistance to heat stress, perhaps as part of a systemic stress signaling pathway (PubMed:29949773). Involved in maintenance of proteostasis (PubMed:29949773). Under hypoxic stress increases lipid levels by positively regulating fatty acid synthesis via fat-7 expression (PubMed:33009389). Associates with homeobox protein ceh-60 at the promoters of some stress-responsive genes to regulate expression; may require phosphorylation for transcriptional repression activity (PubMed:30956009). Acts downstream of nhr-14 to activate transcription of intestinal metal transporter smf-3, modulating innate immunity and iron uptake (PubMed:31532389). May act downstream of the mTORC2 signaling mediated pathway (PubMed:27401555). May act in a mutually exclusive manner with the FOXO transcription factor daf-16 (PubMed:23911329, PubMed:27401555).

6239:CELE C29E6.5
gene id: 6239:CELE_C29E6.5
uniprot id: Q18299
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Ligand-activated transcription factor (By similarity). Positively modulates expression of homeobox protein lin-39, perhaps by binding to the sequence motif 5'-TGAC-3' in regulatory regions of the lin-39 gene, acting in the embryo, and also in the vulval lineage (PubMed:24885717).
messages: Nucleus
messages: RNAi-mediated knockdown reduces expression of homeobox protein lin-39 in vulval precursor cells at the larval L3 stage.

6239:CELE M163.4
gene id: 6239:CELE_M163.4
uniprot id: Q93903
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in gut cells and mature sperm stored in the spermatheca.
messages: Expressed in the developing germ line and throughout embryogenesis and the L1-L4 larval stages.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis.
messages: RNAi-mediated knockdown results in both viable and inviable embryos, but eventually animals display germline maintenance defects and become sterile (PubMed:11861581). Double RNAi-mediated knockdown and/or mutagenesis with such-1 results in increased embryonic lethality and the production of one-cell arrested embryos (PubMed:20944012).
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE Y54G11A.5
gene id: 6239:CELE_Y54G11A.5
uniprot id: Q27487
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Homotetramer.
messages: Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity (PubMed:25243607, PubMed:28456303). Plays a role in maintaining normal lifespan (PubMed:14996832). Plays a role in regulating the response to pathogens such as E.faecalis (PubMed:17483415).
messages: Peroxisome
messages: Shortened lifespan and reduced egg laying capacity (PubMed:14996832). Abolishes ctl-2 enzymatic activity and reduces the global levels of catalase activity to 20% of the total catalase activity observed in wild-type animals (PubMed:14996832). Increased size and clustering of peroxisomes (PubMed:14996832). Increased sensitivity to pathogens (PubMed:17483415). Reduced survival and resistance to E.faecalis in a daf-2 RNAi mutant background (PubMed:17483415).
messages: Up-regulated in response to Cu(2+) (PubMed:25243607). Up-regulated in response to phoxim (an organophosphorus insecticide) and carbaryl (a carbamate insecticide) (PubMed:28456303).
messages: Was originally reported to play a role in determining adult lifespan. However, the paper was later retracted due to errors in the data.

6239:CELE C07E3.9
gene id: 6239:CELE_C07E3.9
uniprot id: Q17790
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

6239:CELE F54C1.5
gene id: 6239:CELE_F54C1.5
uniprot id: Q8I7G4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Expressed in most amphid, both phasmid and several labial-quadrant neurons.
messages: Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (PubMed:16049494). Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors (PubMed:16049494). Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for polyglutamylation of axonemal tubulin in sensory cilia (PubMed:17761526).
messages: Sensory neurons are unable to take up a fluorescent dye from the media, a phenotype that is often associated with aberrant sensory cilia.
messages: cilium

6239:CELE F09G2.3
gene id: 6239:CELE_F09G2.3
uniprot id: O17404
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

6239:CELE C15H11.6
gene id: 6239:CELE_C15H11.6
uniprot id: Q9XVS8
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Involved in the export of cellular mRNA to the cytoplasm (PubMed:23149939). Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939).
messages: Nucleus
messages: RNAi-mediated knockdown results in severe growth retardation, lethality and reduces the accumulation of unspliced tra-2 in the cytoplasm of rnp-4/RBM8A RNAi mutants.
messages: The RNA-binding domain is a non-canonical RNP-type domain.

6239:CELE C34G6.7
gene id: 6239:CELE_C34G6.7
uniprot id: O01498
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the STAM family.
messages: Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.
messages: Endosome
messages: Isoform a, but not isoform b, interacts (via C-terminus) with lov-1 (via C-terminus).
messages: Widely expressed, including the pharyngeal intestinal valve, several head neurons, and phasmids in both males and hermaphrodites throughout development. In males, also expressed in the gonad and sensory neurons in the tail. Expressed in the male-specific ciliate CEM, ray B-type and hook HOB sensory neurons.
messages: cilium

6239:CELE F49C12.11
gene id: 6239:CELE_F49C12.11
uniprot id: Q20588
names: Similarity
messages: Belongs to the TMA7 family.

6239:CELE R09H10.5
gene id: 6239:CELE_R09H10.5
uniprot id: Q21884
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F44G3.2
gene id: 6239:CELE_F44G3.2
uniprot id: O45518
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

6239:CELE F54F2.5
gene id: 6239:CELE_F54F2.5
uniprot id: P34450
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C27H6.1
gene id: 6239:CELE_C27H6.1
uniprot id: P90761
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles.
messages: The Asp-Pro-Phe (DPF) motifs, which are found in many presynatic proteins, are thought to mediate an interaction with Alpha-adaptin.

6239:CELE F19C7.2
gene id: 6239:CELE_F19C7.2
uniprot id: Q19589
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE C09B8.7
gene id: 6239:CELE_C09B8.7
uniprot id: Q17850
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Divalent cations such as magnesium or manganese.
messages: Highly expressed at the embryonic stage, with decreasing expression from L1 onwards.
messages: In pak-1 and pak-2 double mutants, defects in embryogenesis and L1 stage lethality. The few animals reaching adulthood have normal ventral cord commissural motoneuron axonal guidance and are relatively coordinated. In max-2 and pak-1 double mutants, DD and DC motoneuron axons fail to reach the dorsal cord (PubMed:17050621). Animals are also uncoordinated, defective in egg laying and in distal tip cell (DTC) migration, guidance and morphology, and exhibit ventral enclosure defects (PubMed:17050621, PubMed:19023419).
messages: Interacts with cdc-42 (GTP-bound form) and cedd-10 (GTP-bound form).
messages: Perikaryon
messages: Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes (PubMed:17050621). Involved in orientating axonal growth of HSN neurons (PubMed:18499456). During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation (PubMed:19023419, PubMed:19797046). May phosphorylate mlc-4 (PubMed:19675126).
messages: Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, several cells in the tail region (including the B and Y cells from L1 to adult, the hypodermal blast cell T in the L1 and some of its progeny in later stages), and the distal tip cells.
messages: axon

6239:CELE F42G9.1
gene id: 6239:CELE_F42G9.1
uniprot id: P49595
names: Cofactor
names: Similarity
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.

6239:CELE C02E11.1
gene id: 6239:CELE_C02E11.1
uniprot id: H2KYE0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Expressed in body wall, pharyngeal, uterine and vulval muscles, motor neurons, nerve ring, motor and ventral cord neurons, hypodermal cells in the tail, vulval epithelium and intestine.
messages: Expressed in embryos and adults.
messages: Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER) (PubMed:19609303). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303). Specifically, may promote the inclusion of alpha subunit unc-38 into and the exclusion of unc-29 from L-AChR (PubMed:19609303). Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:19609303).
messages: May interact with nra-2 in the ER.

6239:CELE C29E4.4
gene id: 6239:CELE_C29E4.4
uniprot id: P34343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: Important for early nematode development.
messages: Nucleus envelope
messages: nuclear pore complex

6239:CELE F45F2.13
gene id: 6239:CELE_F45F2.13
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE R11A8.5
gene id: 6239:CELE_R11A8.5
uniprot id: Q21925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

6239:CELE F46B3.3
gene id: 6239:CELE_F46B3.3
uniprot id: J7SA59
uniprot id: J7SF92
uniprot id: Q9XV15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C18A11.5
gene id: 6239:CELE_C18A11.5
uniprot id: Q23229
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although clearly related the GHMP kinase family as demonstrated by the 3D-structure, it lacks many conserved feature of GHMP kinases and probably does not bind ATP, suggesting that it probably does not have kinase activity.
messages: Belongs to the GHMP kinase family. Xol-1 subfamily.
messages: Down-regulated by at least 4 X-linked genes, termed X-signal elements including fox-1 and sex-1 (PubMed:9217163). High levels of xol-1 in males correlate with low sdc-2 expression, preventing dosage compensation. Conversely, low levels of xol-1 in hermaphrodites correlate with high sdc-2 expression and the assembly of the dosage compensation complex on the X chromosome.
messages: Inactive isoform (PubMed:7813020, PubMed:33372658). Produced by alternative splicing of intron 6 which results in the retention of intron 6 and deletion of exon 7 coding sequences (PubMed:33372658). An in-frame UAA stop codon within intron 6 prematurely terminates translation (PubMed:7813020). Intron 6 retention and exon 7 deletion can also be due to use of an alternative 3' splice acceptor site in the 3'UTR resulting in trans-splicing to the transcripts of unrelated genes (PubMed:33372658).
messages: Most abundant in male embryos (PubMed:33372658). Expressed at low levels in hermaphrodite embryos (PubMed:33372658).
messages: Nucleus
messages: Only functional isoform (PubMed:33372658). Produced by alternative splicing of intron 6 which results in the deletion of intron 6 and retention of exon 7 coding sequences (PubMed:33372658).
messages: Sex-determining factor that is required for sexual differentiation and X chromosome dosage compensation to promote male development (PubMed:7813020, PubMed:9217163, PubMed:33372658). High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.
messages: Specifically expressed at high levels in pre-comma stage XO embryos. Also present at low levels throughout other larval stages in XO animals, but are nearly undetectable in XX larvae and adults of both sexes.
messages: Worms are XO-lethal, due to inappropriate activating dosage compensation where only 1 X chromosome is present. In contrast xol-1 overexpression is XX-lethal, deactivating the dosage compensation pathway and elevating the expression of X chromosome genes to lethal levels in hermaphrodites.

6239:CELE F48G7.8
gene id: 6239:CELE_F48G7.8
uniprot id: O44587
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54A3.3
gene id: 6239:CELE_F54A3.3
uniprot id: Q9N4J8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity). Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Plays a role in microtubule polymerization (PubMed:16054029).
messages: RNAi-mediated knockdown results in severely reduced microtubule growth rate.

6239:CELE K09A9.2
gene id: 6239:CELE_K09A9.2
uniprot id: Q93874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome
messages: phagosome
messages: trans-Golgi network membrane

6239:CELE Y94H6A.8
gene id: 6239:CELE_Y94H6A.8
uniprot id: Q9N2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

6239:CELE C05B5.2
gene id: 6239:CELE_C05B5.2
uniprot id: P34290
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK54.2
gene id: 6239:CELE_ZK54.2
uniprot id: Q7YZT6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
messages: Expressed in all development stages.
messages: In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: No visible phenotype.

6239:CELE K08F8.2
gene id: 6239:CELE_K08F8.2
uniprot id: Q21361
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcription factor that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many promoters (PubMed:16310763, PubMed:21502138). Involved in the development of the excretory duct cell, by positively modulating embryonic transcription of putative transcription factor lin-48, acting in concert with cell death specification protein ces-2 (PubMed:16310763). Negatively modulates expression of key autophagy-related genes, bec-1/ATG6 and lgg-1/ATG8, and may link together autophagy and apoptosis during development (PubMed:21502138). Positively modulates expression of neuropeptide pigment dispersing factor homologs pdf-1 and pdf-2 (PubMed:19686386).
messages: Belongs to the bZIP family.
messages: Expression begins in the embryo and persists into larval and adult stages (PubMed:16310763). Expressed in the excretory duct cell, as well as other cells, at larval L3 stage (PubMed:16310763).
messages: Interacts with cell death specification protein ces-2.
messages: Nucleus
messages: Phosphorylated by mitogen-activated protein kinases pmk-2 and pmk-3 (PubMed:11703092). May be responsive to osmotic stress (PubMed:11703092).

6239:CELE ZK1251.1
gene id: 6239:CELE_ZK1251.1
uniprot id: Q23429
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE R107.4
gene id: 6239:CELE_R107.4
uniprot id: P32742
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed in oocytes.
messages: Interacts with allo-1 (via N-terminus); the interaction is direct.
messages: RNAi-mediated knockdown results in defective clearance of paternal mitochondria and impaired accumulation of the autophagosome marker lgg-1 in 1-cell stage embryos.
messages: Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy.

6239:CELE ZK524.1
gene id: 6239:CELE_ZK524.1
uniprot id: Q01608
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Expressed during L4 stage, during spermatogenesis, when hermaphrodites produces sperm.
messages: Homodimer. Potential component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable).
messages: Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II (PubMed:9819355, PubMed:29879108). May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis (PubMed:9819355).
messages: The PAL motif is required for normal active site conformation.
messages: cis-Golgi network membrane

6239:CELE C13C4.3
gene id: 6239:CELE_C13C4.3
uniprot id: O01930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK265.5
gene id: 6239:CELE_ZK265.5
uniprot id: Q94403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F11A5.10
gene id: 6239:CELE_F11A5.10
uniprot id: G5EBR3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.
messages: Cell membrane
messages: Glutamate binding is mediated by the extracellular domain. In contrast, the allosteric modulator ivermectin binds between subunits at the periphery of the transmembrane domain, proximal to the extracellular side.
messages: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817). Plays a role in the regulation of locomotor behavior (PubMed:16527366).
messages: Pentamer (PubMed:21572436, PubMed:25143115). Homooligomer, forms functional heterooligomers with glc-2 (PubMed:7935817).
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a decrease in the duration of forward locomotion in the absence of food, and an increase in the frequency of turns.

6239:CELE Y46G5A.5
gene id: 6239:CELE_Y46G5A.5
uniprot id: Q9U2G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

6239:CELE F56D1.5
gene id: 6239:CELE_F56D1.5
uniprot id: Q10130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane

6239:CELE F47F2.1
gene id: 6239:CELE_F47F2.1
uniprot id: Q7JP68
names: Developmental Stage
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.
messages: No obvious expression before embryo hatching but is expressed at later stages (at protein level).

6239:CELE B0035.2
gene id: 6239:CELE_B0035.2
uniprot id: Q17433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

6239:CELE F23B2.5
gene id: 6239:CELE_F23B2.5
uniprot id: P41855
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-1 is expressed in the AVA interneurons, the M5 cholinergic pharyngeal motoneurons, and the AIA, AIY, AVE, AVK, RIG and RMG neurons.
messages: Expressed at about a twofold higher level than isoform Long.
messages: Inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: May be processed by convertase egl-3.
messages: Secreted
messages: Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit.

6239:CELE C34D4.12
gene id: 6239:CELE_C34D4.12
uniprot id: Q18445
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE T07A5.1
gene id: 6239:CELE_T07A5.1
uniprot id: Q10044
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F39B2.10
gene id: 6239:CELE_F39B2.10
uniprot id: O45502
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F30F8.9
gene id: 6239:CELE_F30F8.9
uniprot id: Q8I4K3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE C32C4.1
gene id: 6239:CELE_C32C4.1
uniprot id: A7UQ08
uniprot id: D5MCS0
uniprot id: D9N131
uniprot id: D9N132
uniprot id: D9N133
uniprot id: H9G2X0
uniprot id: J3K003
uniprot id: Q18351
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C10C5.4
gene id: 6239:CELE_C10C5.4
uniprot id: Q17899
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

6239:CELE C07A9.1
gene id: 6239:CELE_C07A9.1
uniprot id: P34312
names: Subcellular Location Annotation
messages: Secreted

6239:CELE AH6.5
gene id: 6239:CELE_AH6.5
uniprot id: Q09436
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581). Also affects formation of intestinal cells (PubMed:10882103).
messages: Interacts (probably when phosphorylated on Thr-190) with plk-1 (via POLO box domain) and plk-2 (via POLO box domain).
messages: Phosphorylation on Ser-457 by par-1 promotes localization of the protein to the anterior cytoplasm of the zygote.
messages: RNAi-mediated knockdown in mex-5 zu199 mutant background causes a loss in plk-1 asymmetric distribution during the first embryonic cell divisions.

6239:CELE C04A11.4
gene id: 6239:CELE_C04A11.4
uniprot id: G5EDW5
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Endosome membrane
messages: Expressed in hyp7 large epidermal syncytium (punctate distribution), seam cell syncytia, anterior epidermis, neurons located in the head, tail and central body, proximal oogenic cells (levels increasing in maturing oocytes) and myoepithelial cells of the spermatheca (at protein level) (PubMed:35639786). Not detected in mature sperm cells (PubMed:35639786).
messages: Expressed throughout embryogenesis.
messages: Lysosome membrane
messages: Metalloprotease that cleaves and releases a number of molecules (By similarity). Negative regulator of lrp-1 protein levels, potentially by influencing its endosomal trafficking (PubMed:35639786). Involved in regulating the molting process (PubMed:35639786).
messages: RNAi-mediated knockdown leads to suppression of molting defects in a nekl-2(fd81);nekl-3(gk894345) double mutant background.
messages: The peptidase M12B domain does not require a conserved Zn-metalloprotease consensus motif to contribute to regulation of lrp-1 protein levels.

6239:CELE Y24D9A.8
gene id: 6239:CELE_Y24D9A.8
uniprot id: Q966C7
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

6239:CELE F20G2.2
gene id: 6239:CELE_F20G2.2
uniprot id: Q93545
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE ZC518.1
gene id: 6239:CELE_ZC518.1
uniprot id: A0A061AJF0
uniprot id: A0A061AL29
uniprot id: A7UQ07
uniprot id: J7SEZ5
uniprot id: Q23369
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.
messages: Membrane

6239:CELE Y73B6BL.13
gene id: 6239:CELE_Y73B6BL.13
uniprot id: Q9GUG4
names: Similarity
messages: Belongs to the MIF family.

6239:CELE F27D9.7
gene id: 6239:CELE_F27D9.7
uniprot id: Q19844
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K10B3.10
gene id: 6239:CELE_K10B3.10
uniprot id: G4S034
uniprot id: Q21408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cytoskeleton

6239:CELE C54G10.2
gene id: 6239:CELE_C54G10.2
uniprot id: Q18841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

6239:CELE VC5.5
gene id: 6239:CELE_VC5.5
uniprot id: Q2V069
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK673.3
gene id: 6239:CELE_ZK673.3
uniprot id: Q09377
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed from the early one-cell or late two-cell stage and continues throughout embryonic and larval development and in adulthood.
messages: Greatly reduced nuclear accumulation of lin-15a protein but no effect on mRNA levels.
messages: Nucleus
messages: Required for translation, stability and/or localization of lin-15a.
messages: Widely expressed throughout embryonic development. Expressed in the six multipotent ventral ectodermal blast cells, P3.p-P8.p, which generate the vulva and in their descendants throughout vulval development.

6239:CELE F39G3.1
gene id: 6239:CELE_F39G3.1
uniprot id: O16276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y49F6B.4
gene id: 6239:CELE_Y49F6B.4
uniprot id: Q9N4U5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1 (PubMed:15254247).
messages: Belongs to the RED family.
messages: Detected at all stages of development, during early embryogenesis and in oocytes, in larvae and adults.
messages: Intrinsically disordered protein (Probable).
messages: Nucleus
messages: Probable component of the spliceosome (By similarity). Heterotetramer with smu-1 (PubMed:27150041). The smu-1 homodimer interacts (via the N-terminal region including the LisH and CTLH domains) with smu-2, giving rise to a heterotetramer (PubMed:15254247, PubMed:27150041).
messages: RNAi-mediated knockdown gives rise to no visible phenotype in wild-type, but suppresses the effects of unc-52 mutations.
messages: Ubiquitous.

6239:CELE C23F12.1
gene id: 6239:CELE_C23F12.1
uniprot id: A0A0K3ASN4
uniprot id: A0A0K3ASN9
uniprot id: A0A0K3AT80
uniprot id: A0A0K3AT86
uniprot id: A0A0K3AVH5
uniprot id: A0A0K3AVH8
uniprot id: A0A0K3AVI4
uniprot id: A0A0K3AW96
uniprot id: A0A0K3AWA2
uniprot id: A0A0K3AYH6
uniprot id: A0A0K3AYI1
uniprot id: D0VWL7
uniprot id: D0VWL8
names: Similarity
messages: Belongs to the filamin family.

6239:CELE M01F1.3
gene id: 6239:CELE_M01F1.3
uniprot id: Q21452
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE F08A8.5
gene id: 6239:CELE_F08A8.5
uniprot id: A5Z2X3
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 11 family.
messages: Expressed throughout development and in adult.
messages: Expression is restricted to pharyngeal neurons and gland cells.
messages: Golgi stack membrane
messages: May form oligomers.
messages: N-glycosylated.
messages: Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->3)-GalNAc-alpha-R, Gal-beta-(1->3)-(GlcNAc-beta-(1->6))-GalNAc-alpha-R and Gal-beta-(1->3)-GalNAc acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc in vitro.

6239:CELE C54C8.1
gene id: 6239:CELE_C54C8.1
uniprot id: O17706
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE W07G9.2
gene id: 6239:CELE_W07G9.2
uniprot id: A0A0K3ARJ9
uniprot id: A0A0K3AUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F59D6.5
gene id: 6239:CELE_F59D6.5
uniprot id: O16341
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T05C3.6
gene id: 6239:CELE_T05C3.6
uniprot id: H2KZ05
names: Similarity
messages: Belongs to the phospholipase D family.

6239:CELE C27A2.6
gene id: 6239:CELE_C27A2.6
uniprot id: Q18239
names: Similarity
messages: Belongs to the DSH family.

6239:CELE K07F5.12
gene id: 6239:CELE_K07F5.12
uniprot id: Q9U3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE C32D5.2
gene id: 6239:CELE_C32D5.2
uniprot id: Q09488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Expressed in pharyngeal, hypodermal and intestinal cells.
messages: Interacts with sma-10 (PubMed:20502686). Interacts with drag-1 (PubMed:24004951).
messages: Membrane
messages: Serine/threonine-protein kinase receptor which binds TGF-beta-like ligands dbl-1 and perhaps daf-7 (PubMed:9847239, PubMed:24004951). Upon ligand binding, probably activates a TGF-beta-like signaling pathway (PubMed:9847239, PubMed:24004951).

6239:CELE T24D11.1
gene id: 6239:CELE_T24D11.1
uniprot id: S6F527
names: Function
names: Subunit
names: Tissue Specificity
messages: Highly expressed in the terminal bulb muscles, pharyngeal muscle, in intestine and vulva.
messages: May interact with rab-6.2 (in GTP-bound form).
messages: Rab GTPase activating protein for the small GTPase rab-6.2 (PubMed:23792950). Required for grinder formation, which is the feeding organ that breaks down food (PubMed:23792950).

6239:CELE F57F5.2
gene id: 6239:CELE_F57F5.2
uniprot id: H2L2D1
uniprot id: P90895
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in BAG sensory neuron.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE F19C6.3
gene id: 6239:CELE_F19C6.3
uniprot id: Q09538
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T15B7.5
gene id: 6239:CELE_T15B7.5
uniprot id: O17035
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T03F6.3
gene id: 6239:CELE_T03F6.3
uniprot id: Q9XVJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

6239:CELE F55B12.5
gene id: 6239:CELE_F55B12.5
uniprot id: Q93796
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Expressed in the body wall muscle cells and detected at the basal surface of pharyngeal cells and basal-lateral membranes of the intestine.
messages: Increased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defect in yolk transport to oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid-induced sterility. Cell corpses persist significantly longer than in the wild-type, indicating a cell corpse clearance defect.
messages: Interacts with ttr-52.
messages: Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development.
messages: Secreted

6239:CELE T02B11.7
gene id: 6239:CELE_T02B11.7
uniprot id: O16977
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal, anal depressor, intestinal and vulva muscles, head neurons and head mesodermal cell.
messages: Metalloprotease.
messages: Secreted

6239:CELE ZK770.1
gene id: 6239:CELE_ZK770.1
uniprot id: O01635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Cell membrane
messages: Homotrimer.
messages: Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized (By similarity). Has high selectivity for sodium ions and can also transport lithium ions with high efficiency (By similarity). Can also transport potassium ions, but with lower efficiency (By similarity). It is nearly impermeable to the larger rubidium and cesium ions (By similarity). Promotes synaptic vesicle fusion to positively regulate the release of dopamine at dopaminergic neuron synapses (PubMed:31494966).

6239:CELE C41G6.7
gene id: 6239:CELE_C41G6.7
uniprot id: O17660
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK520.2
gene id: 6239:CELE_ZK520.2
uniprot id: G5EEV9
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Cytoplasm
messages: Expressed in the intestinal lumen. Also present, at lower levels, in the excretory duct cells.
messages: Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307).
messages: The avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never having been exposed to this pathogenic bacteria.
messages: The extracellular domain is necessary for the uptake of dsRNA.

6239:CELE B0261.2
gene id: 6239:CELE_B0261.2
uniprot id: Q95Q95
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family.
messages: Defects strongly increase lifespan, the mean lifetime being of 25 days instead of 10 days, suggesting that it may be involved in aging process (PubMed:14668850). RNAi-mediated knockdown results in increased longevity and a reduced nucleoli size (PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant background (e1942) reduces the increased longevity and suppresses the reduced nucleoli size of the let-363 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in the germline causes sterility, a severe reduction in the number of germline progenitors and a delay in G2 phase of the cell cycle (PubMed:22278922). RNAi-mediated knockdown results in no sepa-1 containing aggregates at the comma stage of embryonic development indicative of no germ cell specific P-granules at this stage (PubMed:19377305). RNAi-mediated knockdown enhances the loss of touch receptor neurons in a mec-4 u231 mutant (PubMed:17327275).
messages: Nucleus
messages: Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2 (PubMed:12225660). It may have some protein kinase activity instead of lipid kinase activity (PubMed:12225660). May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis (PubMed:19377305). Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1 (PubMed:22278922). Required for larval development (PubMed:22278922). May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing (PubMed:14668850, PubMed:28853436).
messages: Ubiquitous. Expressed in all major tissues and organs, including the intestine, gonads and hypodermal cells (PubMed:12225660). Expressed in neurons (PubMed:17327275).

6239:CELE E02C12.4
gene id: 6239:CELE_E02C12.4
uniprot id: Q65ZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F09G2.8
gene id: 6239:CELE_F09G2.8
uniprot id: O17405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family.
messages: Membrane

6239:CELE R10E11.1
gene id: 6239:CELE_R10E11.1
uniprot id: P34545
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetyltransferase enzyme (By similarity). Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535). In differentiated cells, negatively regulates localization of heterochromatin to the nuclear periphery (PubMed:31118512). Plays a role in migration of gonadal distal tip cells, where it probably modulates expression of genes involved in integrin-mediated adhesion (PubMed:24811939).
messages: Expressed in the gonadal distal tip cells (DTC) during larval stages L2, L3 and L4.
messages: Interacts (via N-terminus domain and HAT domain) with prmt-5; the interaction results in methylation of cbp-1 (PubMed:19521535). Interacts (via HAT domain) with cep-1; cep-1 transcriptional activity may be inhibited by interaction with methylated cbp-1 (PubMed:19521535). Component of a complex that contains prmt-5 and cbp-1 (PubMed:19521535).
messages: Methylation by prmt-5 may repress the capacity of cbp-1 to enhance cep-1-dependent transcription of egl-1.
messages: Nucleus
messages: RNAi-mediated knockdown targeted to the gonadal distal tip cells (DTC) causes DTC migration defects (PubMed:24811939). Significant reduction in expression of src-1, tln-1 and nmy-2 in DTCs (PubMed:24811939). RNAi-mediated knockdown on an mrg-1;cec-4 double mutant background restores positioning of heterochromatin to the nuclear periphery (PubMed:31118512).

6239:CELE R06B9.3
gene id: 6239:CELE_R06B9.3
uniprot id: O17982
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T22B7.4
gene id: 6239:CELE_T22B7.4
uniprot id: Q23039
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C50B6.14
gene id: 6239:CELE_C50B6.14
uniprot id: A5JYV4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F37C12.13
gene id: 6239:CELE_F37C12.13
uniprot id: Q20128
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE C33H5.12
gene id: 6239:CELE_C33H5.12
uniprot id: Q18409
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood.
messages: RNA-mediated interference (RNAi) of rsp-5 and rsp-6 result in fertile animals that exhibit excessive sperm and delayed oocyte production, and sterile animals that develop morphological abnormalities of somatic gonads. Rsp-2/rsp-6 RNAi caused severe abnormalities in somatic gonad structures and in some cases animals were arrested or dead at the larval stage.

6239:CELE ZK622.3
gene id: 6239:CELE_ZK622.3
uniprot id: Q23552
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Catalyzes the first step in the synthesis of phosphocholine by converting phosphoethanolamine into phospho-monomethylethanolamine (N-methylethanolamine phosphate). Phosphocholine is a precursor for phosphatidylcholine, a major component in membranes and a precursor itself in the production of glycoconjugates secreted by parasitic nematodes to avoid host immune responses.
messages: Feedback inhibition by phosphatidylcholine.
messages: Necessary at multiple stages in the worm's life cycle, its disruption alters worm growth and development.

6239:CELE R119.6
gene id: 6239:CELE_R119.6
uniprot id: O61707
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF4 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs) (By similarity). Interacts (via histone-fold domain) with oma-1 (via histone-fold domain) (PubMed:18854162). May also interact with oma-2 (PubMed:18854162). Interacts (via histone-fold domain) with taf-12 (via the histone-fold domain) (PubMed:18854162).
messages: Cytoplasm
messages: Expressed in one-, two- and four-cell embryos and through early morphogenesis (at protein level) (PubMed:11566890, PubMed:18854162). Also expressed in oocytes, and until at least 12-cell stage in embryos (PubMed:18854162).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced severely in embryos (PubMed:11566890). Abolishes expression of a range of genes, including let-858, rps-5, hsp16.2, pes-10, cki-2 and sur-5 (PubMed:11566890). RNAi-mediated knockdown in a Rieske iron-sulfur protein isp-1 mutant background abolishes lifespan extension, drastically reduces fertility, and abolishes induction of expression of glutathione S-transferase gst-4 (PubMed:24107417). Knockdown also significantly shortens lifespan in either tpk-1 or clk-1 mutant backgrounds (PubMed:24107417). Causes significant up-regulation of expression of the translation initiation factor eif-1, in a clk-1 mutant background (PubMed:30198021).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-4 (By similarity). Essential for early embryonic development, probably acting via activating transcription initiation by RNA polymerase II, as part of the TFIID complex (PubMed:18854162, PubMed:11566890). In early embryos, but not oocytes, remains, presumably inactive, in the cytoplasm as a result of binding to oma-1 (PubMed:18854162). Upon degradation of oma-1, taf-4 is released and bound by taf-12, and the taf-4/12 heterodimer translocates to the nucleus and transcriptional repression is relieved (PubMed:18854162). Involved in lifespan extension in a manner dependent upon mitochondrial function (PubMed:24107417). Plays a role in modulating polyribosome formation (PubMed:30198021).
messages: The histone-fold domain mediates hetero-dimer protein-protein interactions.
messages: Throughout PMID:11566890, the gene name taf-5 is used instead of taf-4, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE Y105E8A.14
gene id: 6239:CELE_Y105E8A.14
uniprot id: Q8WQB0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

6239:CELE C27A2.1
gene id: 6239:CELE_C27A2.1
uniprot id: Q18237
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Core component of the smc-5/smc-6 complex (PubMed:20661436). Functions in DNA double strand break repair by promoting sister-chromatid homologous recombination during meiosis (PubMed:20661436, PubMed:27011106, PubMed:27010650, PubMed:24424777). Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway (PubMed:20661436, PubMed:24424777). Also involved in the recovery of stalled replication forks (PubMed:24424777).
messages: Expressed in the germline (at protein level).
messages: Interacts with smc-6.
messages: Nucleus
messages: Reduced fecundity and transgenerational sterility (PubMed:20661436). Increased apoptosis in germ cells and hypersensitivity to ultraviolet and ionizing radiation and hydroxyurea-induced replication stress (PubMed:20661436, PubMed:24424777). Increased rad-51 foci in the mitotic and meiotic germline (PubMed:20661436, PubMed:27010650, PubMed:24424777). Chromosome fragmentation defects and unresolved diakinesis chromosomes in meiotic oocytes (PubMed:20661436, PubMed:27010650). Increased accumulation of homologous recombination intermediates during meiosis (PubMed:20661436, PubMed:27011106, PubMed:27010650). Impaired DNA replication in germ cells (PubMed:24424777). Accumulation of brd-1 and rmh-1 on chromosomes in mitotic germ cells (PubMed:24424777, PubMed:27011106). In a spo-11 mutant background, no accumulation of meiotic rad-51 foci and decrease in chromosome fragmentation (PubMed:20661436). In a him-3 mutant background, increase in rad-51 foci and chromosome fragmentation (PubMed:20661436). RNAi-mediated knockdown of syp-2 leads to an increase of chromosome fragmentation (PubMed:20661436). In a xpc-1 mutant background, increased ultraviolet sensitivity (PubMed:24424777). In a xpc-1 or csb-1 mutant background, enhanced ultraviolet-induced delay in somatic development (PubMed:24424777). In a rmh-1 mutant background, increased embryonic lethality and larval arrest (PubMed:27011106). In a him-6 mutant background, increased cross-over frequency, formation of chromatin bridges, defects in diakinetic chiasmata formation, aberrant distribution of the condensin II subunit hcp-6 and compromised chromosome segregation in meiosis, leading to embryonic lethality (PubMed:27010650).
messages: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc-6, forming a V-shaped heterodimer.

6239:CELE C25F9.13
gene id: 6239:CELE_C25F9.13
uniprot id: A5JYW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y45G12C.9
gene id: 6239:CELE_Y45G12C.9
uniprot id: A0A0M7REE8
uniprot id: G5EG08
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE T07C5.1
gene id: 6239:CELE_T07C5.1
uniprot id: A0A0K3ATD5
uniprot id: A0A0K3AYM2
uniprot id: Q22295
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE T26F2.3
gene id: 6239:CELE_T26F2.3
uniprot id: A5JYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE F43G9.13
gene id: 6239:CELE_F43G9.13
uniprot id: Q95QG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

6239:CELE C05C8.8
gene id: 6239:CELE_C05C8.8
uniprot id: O16316
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y95D11A.1
gene id: 6239:CELE_Y95D11A.1
uniprot id: Q9U1P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

6239:CELE CD4.4
gene id: 6239:CELE_CD4.4
uniprot id: O44158
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Late endosome membrane

6239:CELE C06A1.1
gene id: 6239:CELE_C06A1.1
uniprot id: P54811
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates (PubMed:18854144, PubMed:18782221, PubMed:22768338). Can also prevent aggregation of unfolded proteins also in an ATP-independent manner (PubMed:18782221). Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains (PubMed:19545544). Involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:17825049, PubMed:21317884, PubMed:22768338, PubMed:25652260). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:17825049, PubMed:21317884, PubMed:22768338, PubMed:25652260). In association with helicase him-6 and GTPase crp-1, regulates the unfolded protein response (UPR) following ER stress, probably independently of the ERAD pathway (PubMed:18458060). Together with udf-2 and chn-1, regulates myosin assembly in body wall muscles by targeting myosin chaperone unc-45 for proteasomal degradation (PubMed:17369820). Together with the ufd-1-npl-4 complex, controls the switch from spermatogenesis to oogenesis by regulating E3 ligase cul-2 complex-mediated tra-1 proteasomal degradation (PubMed:19773360). During oocyte meiosis and together with cdc-48.2, required for chromosome condensation at the diakinesis phase in prophase I and for progression of metaphase I (PubMed:17512499). During the first embryonic cell division, regulates DNA replication and thus chromosome segregation and decondensation, and nuclear envelope re-assembly (PubMed:18097415, PubMed:18854144, PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). In S phase and in association with ufd-1, npl-4.1 and/or npl-4.2 and ubxn-3, ensures the degradation of DNA licensing factor c…
messages: Belongs to the AAA ATPase family. CDC48 subfamily.
messages: Cytoplasm
messages: Expressed highly in embryos (at protein level) (PubMed:16701565, PubMed:17369820). Expression decreases in larvae and increases again in adults (at protein level) (PubMed:16701565, PubMed:17369820). At the L4 larval stage, expressed in the proximal gonad, predominantly at the pachytene stage and in spermatocytes (PubMed:19773360). Not expressed in sperm (PubMed:19773360).
messages: Expressed in germ cells and spermatheca (PubMed:16701565). Expressed in body wall muscles (PubMed:17369820).
messages: Homohexamer; oligomerization is ATP-independent (PubMed:18782221, PubMed:24055316). Forms a ring-shaped particle of 18.3 nm diameter, that displays 6-fold radial symmetry (PubMed:24055316). Interacts with cdc-48.2 and thus may form heterohexamers (PubMed:16647269, PubMed:17369820, PubMed:25721663). Forms a complex composed of cdc-48.1, him-6 and crp-1; within the complex, interacts with helicase him-6 and GTPase crp-1 (PubMed:18458060). Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1; within the complex, interacts (via N-terminus) with ubxn-5 and with atx-3 (PubMed:19545544). Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1; within the complex, interacts with atx-3 and (via DDDLYN motif) with ufd-2 (PubMed:21317884, PubMed:27669035). Interacts (via N-terminus) with atx-3 (via RRDR motif); the interaction is not required for atx-3 enzymatic activity (PubMed:19545544, PubMed:21317884). Forms a complex composed of cdc-48.1, myosin chaperone unc-45, ubiquitin-protein ligases ufd-2 and chn-1; within the complex, interacts (via DDDLYN motif) with ufd-2 and targets myosin chaperone unc-45 for proteasomal degradation (PubMed:17369820, PubMed:27669035). Forms a complex composed of ubxn-3, ufd-1, npl-4.1 and cdc-48.1; within the complex, interacts (via N-terminus) with ubxn-3 (via FPK motif) and with ufd-1 (PubMed:16647269, PubMed:20977550). Forms a complex composed of ubxn-3, cdc-48.1 and/or cdc-48.2 and substrate cdt-1 (PubMed:26842564). Interacts (via N-terminus) with ubxn-1 (PubMed:16647269, PubMed:20977550). Interacts (via N-terminus) with ubxn-2 (PubMed:23649807, PubMed:20977550). Interacts (via N-terminus) with ubxn-4 (PubMed:20977550). Interacts with ubxn-6 (PubMed:20977550). Interacts with ufd-3 (PubMed:25721663). Does not interact with air-2 (PubMed:18854144).
messages: Induced upon ER stress. Repressed by starvation and oxidative stress.
messages: RNAi-mediated knockdown causes partial embryonic lethality (PubMed:15716356, PubMed:18854144). Impairs response to ER stress (PubMed:18458060). Abnormal accumulation of myosin chaperone unc-45 in body wall muscles (PubMed:17369820). RNAi-mediated knockdown in an unc-45 (m94) mutant background, restores motility (PubMed:17369820). Simultaneous RNAi-mediated knockdown of cdc-48.2 in embryos causes embryonic lethality (PubMed:15716356, PubMed:16647269, PubMed:18097415, PubMed:18854144, PubMed:18728180). Defects in oocyte meiosis I progression (PubMed:17512499). Defects in embryo S phase DNA replication causing delays in cell cycle progression (PubMed:17512499, PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). At the end of mitosis, impairs chromatin decondensation and nuclear envelope re-assembly (PubMed:18728180, PubMed:18854144, PubMed:18097415). In addition, abnormal accumulation of air-2 on mitotic chromatin and impaired air-2 activation (PubMed:18097415). Does not affect ER transition into sheet-like structures at the onset of embryonic mitosis (PubMed:15716356). Simultaneous RNAi-mediated knockdown of cdc-48.2 in young adults decreases lifespan, induces the unfolded protein response, increases overall levels of polyubiquitinated proteins, and impairs the degradation of misfolded ER proteins (PubMed:16647269, PubMed:17825049, PubMed:17369820, PubMed:21317884, PubMed:22768338). Causes defects in germline development (PubMed:20977550). In an atx-3 (gk193) mutant background, causes a 50 percent increase in longevity, a delay in age-related muscle degeneration and resistance to oxidative and heat stresses (PubMed:21317884).
messages: The first ATP-binding region has low ATPase activity (PubMed:21454554). The second ATP-binding region is responsible for ATPase activity (PubMed:21454554). ATP binding to the first ATP-binding region induces intrinsic activity of the second ATP-binding region (PubMed:21454554). While ATP binding to the first ATP-binding region appears to prevent ATP hydrolysis by the second ATP-binding region, ADP-binding to first region promotes the coordinate and cooperative ATPase cycle of the second ATP-binding region (PubMed:21454554). ATP binding to the first ATP-binding region induces a conformational change, promoting the rotation of the first ATP-binding region relative to the second ATP-binding region in the hexamer (PubMed:24055316). Inhibited by N-ethylmaleimide (NEM) (PubMed:18782221).
messages: The role of cdc-48.1 in the regulation of kinase air-2, a component of the chromosomal passenger complex (CPC), is controversial. One study suggests that cdc-48.1 inactivates air-2 at the end of mitosis whereas a second study shows that cdc-48.1 is not implicated in the regulation of air-2.
messages: perinuclear region

6239:CELE F44F4.5
gene id: 6239:CELE_F44F4.5
uniprot id: Q20405
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein sra family.
messages: Expressed in the URX sensory neuron, the ALA interneuron and in additional interneurons, pharyngeal neurons and muscle.
messages: Membrane

6239:CELE C40H5.5
gene id: 6239:CELE_C40H5.5
uniprot id: G5EE86
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals are cryophilic and move toward lower temperatures irrespective of cultivation temperature in contrast to wild-type animals which move toward their cultivation temperature when placed on a temperature gradient. AIA and AIY interneurons display defective neurite morphology. NSM neurons display loss of or reduced expression of a number of terminal identity markers including cat-4, flp-4, bas-1, ptps-1 and mgl-1. Reduced expression of ceh-23, kal-1, C36B7.7, ser-2, unc-17 and sra-11 is observed in AIY interneurons. Preexposure to odorants fails to leave an olfactory imprint. Mean lifespan is reduced by 10% with decreased pharyngeal pumping and increased intestinal autofluorescence caused by lysosomal deposits of lipofuscin, indicative of cellular damage and aging. Formation of very few dauers in starvation conditions. No defects observed in brood size, egg number or chemotactic behavior toward volatile chemicals.
messages: Expressed in the AIA, AIN and AIY interneurons, and in the NSM neurons. Expressed also in ADL and ASI sensory neurons in 60-70% of L2 larvae. Expression is also detected in head muscles of embryos and some early larvae but not late larvae or adults.
messages: First expressed at the end of embryo gastrulation in a pair of ventral neuroblasts, the left/right symmetric pair of SMDD/AIY mother cells, ABpl/rpapaaa, also known as NB(SMDD/AIY) (PubMed:19386265). Transiently expressed in SMDD motor neurons immediately after cleavage of the SMDD/AIY mother cells and then expression disappears during embryonic elongation (PubMed:19386265). Expressed during embryogenesis and persists through to adulthood in AIY interneurons (PubMed:11493519, PubMed:19386265). Expressed at L1 stage and through adulthood in AIA and NSM neurons (PubMed:24353061, PubMed:11493519). Expression is detected in head muscles of all 1.5 and 2-fold embryos, 47% of embryos just before hatching and 6% of early larvae with no expression in head muscles of late stage larvae or adults (PubMed:9292724).
messages: Nucleus
messages: Perikaryon
messages: Transcription factor (PubMed:15177025, PubMed:19386265). Binds to a sequence motif, 5'-TTATTGGCTTCGTTAA-3', which may be involved in AIY interneuron function, in the regulatory elements of target genes; binding is more efficient, in vitro, together with homeobox protein ceh-10 (PubMed:15177025). Required for specification of the AIA and AIY interneurons and the NSM neurons (PubMed:11493519, PubMed:24353061). Positively regulates the expression of a number of genes including ceh-10, ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY neurons, and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons (PubMed:11493519, PubMed:24353061, PubMed:19386265, PubMed:15177025). In concert with WNT/beta-catenin signaling, initiates expression of homeobox ceh-10 in AIY, but not in the sister cells, SMDD motor neurons (PubMed:19386265). Also acts in an autoregulatory feedback loop to maintain its own expression (PubMed:9292724, PubMed:19386265). Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding (PubMed:9292724, PubMed:16051801, PubMed:21055415, PubMed:24353061). Not required for normal chemosensory behavior (PubMed:9292724).
messages: axon

6239:CELE T11F9.11
gene id: 6239:CELE_T11F9.11
uniprot id: Q22392
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F48E3.3
gene id: 6239:CELE_F48E3.3
uniprot id: Q9GPA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

6239:CELE T24C4.6
gene id: 6239:CELE_T24C4.6
uniprot id: Q2WF59
names: Function
names: Subunit
messages: Acts as target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1.
messages: Interacts with elc-1. Part of an E3 ubiquitin ligase complex including zer-11, cul-2 and elc-1.

6239:CELE F10C1.2
gene id: 6239:CELE_F10C1.2
uniprot id: Q19289
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2.
messages: Expressed in epidermal cells. Expressed in amphid sensory neurons, the excretory cells, the vulva, the uterus, the rectum and some neurons of the tail. Isoform a and isoform b display a similar pattern of expression. Isoform a is predominant in pharyngeal tonofilaments.
messages: Forms some heteromeric filaments with ifa-1, ifa-2, ifa-3 and probably ifa-4.
messages: RNAi-mediated knockdown results in 79% embryonic lethality and 19% larval lethality. Abnormal localization of epidermal structural protein pat-12 during embryogenesis.

6239:CELE D2092.3
gene id: 6239:CELE_D2092.3
uniprot id: P91197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE K06B4.8
gene id: 6239:CELE_K06B4.8
uniprot id: O45664
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T23C6.3
gene id: 6239:CELE_T23C6.3
uniprot id: O02039
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expression begins at the gastrulation stage. Expressed predominantly in the intestine from the comma stage onwards. In early larval stages, expressed in hypodermis and intestine. At L3 larval stage expressed transiently in spermatheca and dorsal uterus.
messages: Nucleus

6239:CELE R07B7.15
gene id: 6239:CELE_R07B7.15
uniprot id: Q21805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE H14A12.2
gene id: 6239:CELE_H14A12.2
uniprot id: O17214
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.
messages: Cytoplasm
messages: Homotetramer.
messages: Mitochondrion matrix
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

6239:CELE T26A5.6
gene id: 6239:CELE_T26A5.6
uniprot id: Q22794
names: Subcellular Location Annotation
messages: Recycling endosome

6239:CELE Y48A6B.3
gene id: 6239:CELE_Y48A6B.3
uniprot id: Q9XXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE K06A4.3
gene id: 6239:CELE_K06A4.3
uniprot id: Q21253
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping) (PubMed:18640981, PubMed:20392036). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends (PubMed:18640981, PubMed:20392036). By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development (PubMed:26074078).
messages: Cleavage by caspase ced-3 activates its actin-severing function and is required for the elimination of presynaptic components during development.
messages: Monomer. Binds to actin monomers and filaments.
messages: cytoskeleton

6239:CELE F57A10.5
gene id: 6239:CELE_F57A10.5
uniprot id: O17898
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed from embryogenesis onwards with high expression during the larval stages of development, peaking at the L3 stage and decreasing at the L4 stage of larval development. Ubiquitously expressed, but expression in seam cells begins in embryonic precursors soon after fertilization and is most prominent in larval stages of development. Expression is also prominent in the germ line during the L1 stage of larval development. Also expressed in pharyngeal gland cells, VC4 and VC5 neurons, and in the hermaphrodite uterine vulval uv1 cells.
messages: Nucleus
messages: Orphan nuclear receptor (Potential). Required for embryonic and larval morphogenesis and probably for seam cell positioning and migration.
messages: RNAi-mediated knockdown results in arrest at the two-fold stage of embryogenesis in the majority of embryos. These embryos have incomplete ventral closure and morphological defects including elongation defects, and either absent or irregularly placed seam cells in the head and tail regions. Surviving larvae also exhibit morphological defects and contain vacuoles.

6239:CELE C50E10.9
gene id: 6239:CELE_C50E10.9
uniprot id: A3QMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C25A1.12
gene id: 6239:CELE_C25A1.12
uniprot id: O02218
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts coordinately with atgl-1 within the lipolytic cascade to distribute stored energy to tissues during nutritional deprivation.
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Interacts with atgl-1.
messages: Lipid droplet
messages: RNAi-mediated knockdown suppresses fasting-induced oxygen consumption.

6239:CELE ZK994.3
gene id: 6239:CELE_ZK994.3
uniprot id: Q1ENI8
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.
messages: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (By similarity). Plays a role in the attachment of tissues and in axonal guidance during early developmental stages (PubMed:25475546). May functionally antagonize the peroxidasin pxn-2 to maintain neuronal development (PubMed:20876652, PubMed:26194821).
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in the ventral nerve cord, the dorsal nerve cord, head neurons, GABAergic and cholinergic neurons, body wall muscles, vulval muscles, uterine muscles, intestine, the hypodermis and in coelomocytes.
messages: extracellular matrix

6239:CELE T05A1.1
gene id: 6239:CELE_T05A1.1
uniprot id: G5ED22
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE T28C12.4
gene id: 6239:CELE_T28C12.4
uniprot id: O16695
uniprot id: Q4LDP0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C08H9.3
gene id: 6239:CELE_C08H9.3
uniprot id: P52887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

6239:CELE F25G6.3
gene id: 6239:CELE_F25G6.3
uniprot id: P48180
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Expressed in the body wall muscle.
messages: Postsynaptic cell membrane
messages: Uncoordinated movement and reduced body wall muscle currents. These phenotypes are probably related.

6239:CELE F52C12.3
gene id: 6239:CELE_F52C12.3
uniprot id: Q9TXV5
names: Similarity
messages: Belongs to the SEN54 family.

6239:CELE T18D3.2
gene id: 6239:CELE_T18D3.2
uniprot id: P41933
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Down-regulated by the cyanotoxin microcystin-LR.
messages: Expressed predominantly in the AWA neurons.
messages: Heterodimer with a partner that confers DNA binding capacity or a nuclear hormone receptor whose DNA binding it inhibits.
messages: May be expressed at all postembryonic stages.
messages: Nucleus
messages: Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity.
messages: Worms are defective in chemotaxis to the volatile odorants diacetyl and pyrazine and weakly defective in chemotaxis to 2,4,5-trimethylthiazole, but respond normally to the odorants benzaldehyde, butanone, and isoamyl alcohol.
messages: perinuclear region

6239:CELE C24H11.9
gene id: 6239:CELE_C24H11.9
uniprot id: Q6BER6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex (By similarity). Interacts with let49/mdt-7.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Nucleus

6239:CELE T23G7.4
gene id: 6239:CELE_T23G7.4
uniprot id: Q22706
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE Y116A8C.32
gene id: 6239:CELE_Y116A8C.32
uniprot id: G5EF97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

6239:CELE T04G9.2
gene id: 6239:CELE_T04G9.2
uniprot id: P55115
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal marginal cells and muscles.
messages: Metalloprotease.
messages: Secreted

6239:CELE B0304.1
gene id: 6239:CELE_B0304.1
uniprot id: P22980
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Body wall muscle cells; in clonal muscle precursors, in a set of early embryonic blastomeres (the ms-granddaughters), and in six glial-like cells called GLRS.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in myogenesis, in cooperation with transcription factors unc-120 and hnd-1 (PubMed:2175254, PubMed:15892873, PubMed:17142668). Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2 (PubMed:21307099).
messages: Nucleus
messages: RNAi-mediated knockdown results in a low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hnd-1 or unc-120 mutant background (PubMed:15892873). Many embryos that survive to hatch become uncoordinated, dumpy larvae (PubMed:15892873). Double RNAi-mediated knockdown with sem-2 results in no sex myoblast production (PubMed:21307099).

6239:CELE Y47G6A.6
gene id: 6239:CELE_Y47G6A.6
uniprot id: Q9N3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

6239:CELE Y8A9A.6
gene id: 6239:CELE_Y8A9A.6
uniprot id: Q9TYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE Y51H4A.25
gene id: 6239:CELE_Y51H4A.25
uniprot id: A0A078BPF3
uniprot id: Q7K6V2
names: Caution
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE T10B9.1
gene id: 6239:CELE_T10B9.1
uniprot id: Q27513
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE Y73B6A.5
gene id: 6239:CELE_Y73B6A.5
uniprot id: Q07292
uniprot id: V6CJK3
uniprot id: V6CKR7
uniprot id: V6CM38
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Gld-1 binds to the 3'-UTR of lin-45 mRNA and is able to protect nonsense-containing lin-45 mRNA from nonsense mediated decay (NMD).
messages: Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.
messages: Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915).
messages: RNAi-mediated knockdown causes a defect in pachytene progression resulting in a proximal gonad devoid of nuclei. The phenotype is more severe in gck-1 (km15) mutant (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915).

6239:CELE C05A9.1
gene id: 6239:CELE_C05A9.1
uniprot id: B6VQ78
uniprot id: Q17645
names: Subcellular Location Annotation
messages: Membrane

6239:CELE D2045.5
gene id: 6239:CELE_D2045.5
uniprot id: Q18984
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE T05A7.8
gene id: 6239:CELE_T05A7.8
uniprot id: Q22209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C44C3.6
gene id: 6239:CELE_C44C3.6
uniprot id: Q8IFY0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K01A6.2
gene id: 6239:CELE_K01A6.2
uniprot id: C1P633
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F44A2.4
gene id: 6239:CELE_F44A2.4
uniprot id: Q20379
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C50E10.11
gene id: 6239:CELE_C50E10.11
uniprot id: A3QMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F16A11.2
gene id: 6239:CELE_F16A11.2
uniprot id: P90838
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs (PubMed:25366321). Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress-induced unfolded protein response (PubMed:25366321, PubMed:25429148). Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1 (PubMed:25429148).
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Mutants are sterile and few are viable (PubMed:25366321, PubMed:25429148). Mutants have a slower growth rate, reduced lifespan and have defective vulval development displaying a severe protruding vulva phenotype (PubMed:25366321, PubMed:25429148). Mutants have disrupted RNA ligase activity which results in the presence of unligated tRNAs and defective tRNA processing (PubMed:25366321). RNAi-mediated knockdown results in reduced sensitivity to tunicamycin-induced endoplasmic reticulum (ER) stress and significantly reduced levels of spliced xbp-1 mRNA under tunicamycin-induced ER stress and non-stressed conditions (PubMed:25429148). RNAi-mediated knockdown in dopamine neurons enhances degenerative effects induced by alpha-synuclein and the neurotoxin, 6-OHDA (PubMed:25429148).
messages: Nucleus

6239:CELE T04H1.4
gene id: 6239:CELE_T04H1.4
uniprot id: A5JYU5
uniprot id: O44199
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.
messages: Homodimer. Probable component of the MRN complex with mre-11 (By similarity).
messages: Nucleus
messages: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).

6239:CELE Y46G5A.31
gene id: 6239:CELE_Y46G5A.31
uniprot id: Q9U2D9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 3 family.
messages: Forms a hetero-octamer with each protomer of the gsy-1 homotetramer bound to one molecule of gyg-1. The N-terminus is involved in interprotomer contacts with gyg-1. The interaction with gyg-1 is required for glycogen production but is not required for gsy-1 intrinsic activity.
messages: RNAi-mediated knockdown results in reduced survival.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

6239:CELE E03A3.4
gene id: 6239:CELE_E03A3.4
uniprot id: Q27490
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

6239:CELE C15H11.8
gene id: 6239:CELE_C15H11.8
uniprot id: O17587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

6239:CELE C26C6.3
gene id: 6239:CELE_C26C6.3
uniprot id: Q18206
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in hypodermal cells. Also detected in the hypodermal seam cells in L4 larvae and young adults. In old adult hermaphrodites, it localizes to the vulva (at protein level).
messages: Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:15255192).
messages: Secreted
messages: Worms exhibit a trail of old cuticle that remains attached to the posterior part of the body.

6239:CELE ZC504.3
gene id: 6239:CELE_ZC504.3
uniprot id: Q23357
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Expressed in somatic cells and at varying levels throughout the germline (at protein level) (PubMed:29886128). Highly expressed in the germ line of hermaphrodites (at protein level) (PubMed:29886128).
messages: Expression in embryos increases as development proceeds (at protein level).
messages: Nucleus
messages: Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L (PubMed:29886128). Acts partially redundantly with cdk-11.1 to ensure embryonic viability (PubMed:29886128). In contrast to cdk-11.1, not essential for male and female fertility (PubMed:29886128).
messages: Viable, with no visible phenotype (PubMed:29886128). Knockout combined with RNAi-mediated knockdown of cdk-11.1 at the L1 stage of larval development results in sterility (PubMed:29886128). Knockout combined with RNAi-mediated knockdown of cdk-11.1 at the L4 larval stage results in fertile adults that produce few viable embryos (PubMed:29886128).

6239:CELE F53G12.6
gene id: 6239:CELE_F53G12.6
uniprot id: O01798
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Expression is restricted to male germline.
messages: Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.

6239:CELE F15H10.3
gene id: 6239:CELE_F15H10.3
uniprot id: H2L2B8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC10 family.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins.
messages: RNAi-mediated knockdown results in both viable and inviable embryos, but eventually animals display germline maintenance defects and become sterile.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE F35G12.8
gene id: 6239:CELE_F35G12.8
uniprot id: Q20060
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:11914278, PubMed:19781752). The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases (PubMed:11914278). Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation (PubMed:19119011, PubMed:19781752). Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation (PubMed:11914278, PubMed:19119011, PubMed:23684975). Plays a role in robust cytokinesis upon the presence of chromatin obstructions (PubMed:23684975).
messages: Chromosome
messages: Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19119011, PubMed:11914278, PubMed:19781752). Within the complex, interacts with mix-1, dpy-26, capg-1 and dpy-28 (PubMed:11914278, PubMed:19781752, PubMed:19119011, PubMed:28301465). Component of the condensin II complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits, kle-2, capg-2 and hcp-6 that probably regulate the complex (PubMed:19781752, PubMed:19119011). Within the complex, interacts with mix-1, kle-2, capg-2 and hcp-6 (PubMed:19781752, PubMed:19119011, PubMed:28301465). Interacts with smcl-1 (PubMed:28301465).
messages: Nucleus
messages: RNAi-mediated knockdown disrupts prometaphase chromosome organization and chromosome segregation in mitosis and meiosis II and leads to aneuploidy throughout development (PubMed:11914278, PubMed:23684975). Disrupts mix-1 localization to mitotic chromosomes (PubMed:11914278). Increased levels of phosphorylated air-2 at the spindle midzone, indicating activation of the abscission checkpoint (PubMed:23684975). Results in cleavage furrow regression and failed cytokinesis during the first and second embryonic divisions (PubMed:23684975).
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with mix-1, forming a V-shaped heterodimer.

6239:CELE B0336.8
gene id: 6239:CELE_B0336.8
uniprot id: Q10931
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Expressed at low levels in embryos.
messages: Most likely a component of a complex at least containing atg-5, lgg-3/ATG12, atg-16.1 and/or atg-16.2 (Probable). Interacts with atg-5 (By similarity). Interacts (via the LIR motif) with lgg-2; the interaction is direct (PubMed:26687600).
messages: Preautophagosomal structure membrane
messages: RNAi-mediated knockdown causes no visible phenotype, but animals have a reduced lifespan (PubMed:17204841). Accumulation of pgl-1-positive P granules in somatic cells (PubMed:19167332). Reduced lgg-1-positive autophagosomes in seam cells (PubMed:28758895). Delayed removal of paternal mitochondria in fertilized eggs (PubMed:22105480). RNAi-mediated knockdown reduces autophagic degradation of membrane pore-forming toxin Cry5B.
messages: The LIR motif (LC3-interacting region) is required for its interaction with lgg-2.
messages: Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin-like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane (PubMed:26687600, PubMed:28758895). Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable). Involved in the degradation of P-granules by autophagy in somatic cells (PubMed:19167332). This ensures exclusive localization of the P-granules in germ cells (PubMed:19167332). Involved in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480). Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098). Also plays a role in membrane-pore repair (PubMed:27875098).

6239:CELE ZK550.6
gene id: 6239:CELE_ZK550.6
uniprot id: O62515
names: Function
names: Similarity
messages: Belongs to the PhyH family.
messages: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.

6239:CELE F35E8.6
gene id: 6239:CELE_F35E8.6
uniprot id: O45452
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F21G4.6
gene id: 6239:CELE_F21G4.6
uniprot id: Q93547
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE F20H11.3
gene id: 6239:CELE_F20H11.3
uniprot id: O02640
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible conversion of (S)-malate to oxaloacetate in the citric acid cycle.
messages: Homodimer.
messages: Mitochondrion matrix

6239:CELE K02F3.12
gene id: 6239:CELE_K02F3.12
uniprot id: Q9TXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).
messages: Nucleus

6239:CELE T10H4.10
gene id: 6239:CELE_T10H4.10
uniprot id: O62378
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE ZK863.6
gene id: 6239:CELE_ZK863.6
uniprot id: Q10661
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dpy-30 family.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with cfp-1 and wdr-5.1 (PubMed:31602465). Interacts with jmjd-3.1 (PubMed:25124442).
messages: Essential for dosage compensation (PubMed:7588066). Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes (PubMed:7588066, PubMed:8939869). Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2 (PubMed:23884442). Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Expressed both maternally and zygotically in all stages.
messages: Nucleus
messages: RNAi-mediated knockdown suppresses the growth delay and elevated body fat index of the TOR complex 2 mutant rict-1 (PubMed:23884442). Results in disruption of the invariant transdifferentiation of the Y rectal cell to the PDA motor neuron (PubMed:25124442).

6239:CELE C01F6.6
gene id: 6239:CELE_C01F6.6
uniprot id: G5EDM4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Expressed in larval and adult stages.
messages: Expressed in the excretory canal and intestine (PubMed:22916205). Expressed on the apical cell membrane of intestinal cells (at protein level) (PubMed:22916205).
messages: Interacts (via PDZ 2 domain) with aat-6 (via PDZ-binding motif); the interaction sequesters aat-6 to the apical cell membrane of intestinal cells.
messages: Phosphorylated.
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis (PubMed:22916205). May play a role in promoting fertility (PubMed:30560135).
messages: The PDZ 2 domain is required for the interaction with the amino acid transporter protein aat-6.
messages: Viable, with no gross anatomy or growth defects observed (PubMed:22916205). Localization of aat-6 at the intestinal apical cell membrane diminishes as animals age, and eventually aat-6 becomes diffusely dispersed in the cytoplasm (PubMed:22916205). RNAi-mediated knockdown in a pept-1 (lg601) mutant background results in a reduced number of progeny (PubMed:30560135).
messages: microvillus membrane

6239:CELE F56B3.12
gene id: 6239:CELE_F56B3.12
uniprot id: Q8WSN2
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE C03F11.3
gene id: 6239:CELE_C03F11.3
uniprot id: Q11124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Membrane

6239:CELE T14G10.6
gene id: 6239:CELE_T14G10.6
uniprot id: Q22495
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Expressed in embryos, larvae and in adults. Expressed in the developing vulva at the L4 larval stage and in the hypodermis at the L3 larval stage (PubMed:28068334). Expressed in hypodermis at larval stage L4 (PubMed:31988138).
messages: Expressed in the germline.
messages: Functions redundantly with tsp-14 isoform a to regulate body size, embryonic and vulva development (PubMed:25978409, PubMed:28068334, PubMed:35089916). Functions redundantly with tsp-14 (isoforms a and b) to regulate cell fate specification in the postembryonic mesodermal M lineage and male development (PubMed:25978409, PubMed:28068334, PubMed:35089916). May regulate BMP-like Sma/Mab signaling by mediating protease sup-17 trafficking to the cell surface (PubMed:28068334). Together with tsp-14, functions redundantly to maintain cell surface levels of the BMP type II receptor daf-4 (but not BMP type I receptor sma-6), probably by regulating endosomal sorting of receptors and their targeting to degradative lysosomes (PubMed:31988138). Together with tsp-14 involved in maintaining the structural and functional integrity of the endosomal network (PubMed:31988138). Together with tsp-14, probably acts by modulating the activation of glp-1, a Notch-like receptor, to regulate germline maturation (PubMed:20220101). Probably acts by modulating the activation of lin-12, a Notch-like receptor, to regulate cell fate specification such as the anchor cell/ventral uterine precursor cell decision (PubMed:20220101).
messages: Late endosome membrane
messages: May interact with protease sup-17; the interaction promotes sup-17 cell membrane localization.
messages: Recycling endosome membrane
messages: Viable and fertile (PubMed:28068334). In embryos, loss of protease sup-17 cell membrane localization (PubMed:28068334). No effect on tsp-14 protein levels or subcellular localization (PubMed:31988138). In a tsp-14 (jj95) mutant background, reduced RAD-SMAD reporter expression, a reporter system for the sma-6/daf-4 BMP-like pathway (PubMed:28068334). In a tsp-14 (jj95) or tsp-14 (jj304) isoform a-specific mutant background, exhibits vulva morphogenesis defects resulting in vulvaless or protruding vulva phenotype, impaired egg-laying with severe maternal effect embryonic lethality and smaller body size (PubMed:28068334, PubMed:35089916). In a tsp-14 (jj95) mutant background, males have severe tail defects including crumpled spicules, fused and shortened sensory rays and smaller fans (PubMed:28068334). F1 progeny die at the late embryonic stage with defects in ventral enclosure (PubMed:28068334). Reduces daf-4 cell surface levels in hypodermal cells and mis-localization to lysosomes and lysosome-related organelles (PubMed:31988138). Alters endosomal morphology (PubMed:31988138). In a sma-9 (cc604) and tsp-14 (jj95) double mutant background, restores the production of the 2 M lineage-derived coelomocytes (PubMed:28068334). In a tsp-14 (jj317) isoform b-specific knockdown, partially restores the production of the 2 M lineage-derived coelomocytes (PubMed:35089916). In a glp-1 (ar202) mutant background, partially restores normal fertility (PubMed:20220101). In a glp-1 (e2142) mutant background, enhances embryonic lethality (PubMed:20220101). In a sup-17 (n1258) or adm-4 (ok265) mutant background, causes lethality at various developmental stages (PubMed:20220101). In a lin-12 (n302) mutant background, restores egg-laying function (PubMed:20220101).
messages: trans-Golgi network membrane

6239:CELE F56F4.9
gene id: 6239:CELE_F56F4.9
uniprot id: A8DZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y59A8B.7
gene id: 6239:CELE_Y59A8B.7
uniprot id: Q9GRZ1
names: Similarity
messages: Belongs to the MAPRE family.

6239:CELE F28C1.3
gene id: 6239:CELE_F28C1.3
uniprot id: Q19857
names: Similarity
messages: Belongs to the PPP1R37 family.

6239:CELE F22D6.11
gene id: 6239:CELE_F22D6.11
uniprot id: Q19730
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F32A6.4
gene id: 6239:CELE_F32A6.4
uniprot id: A0A131MD77
uniprot id: Q19955
names: Similarity
messages: Belongs to the GPSM family.

6239:CELE C05H8.1
gene id: 6239:CELE_C05H8.1
uniprot id: Q3Y416
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Activated by Ca(2+)/calmodulin (PubMed:10336483, PubMed:10428833). Binding of calmodulin may relieve intrasteric autoinhibition (By similarity).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1 (PubMed:10336483, PubMed:10428833, PubMed:12231504). Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation (PubMed:12231504).
messages: Expressed in head and tail neurons and vulval muscles.
messages: The RP domain (arginine/proline-rich) is involved in the recognition of substrates such as cmk-1.
messages: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.

6239:CELE T19D12.6
gene id: 6239:CELE_T19D12.6
uniprot id: Q22574
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y49A3A.5
gene id: 6239:CELE_Y49A3A.5
uniprot id: P52009
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE R05F9.1
gene id: 6239:CELE_R05F9.1
uniprot id: Q21747
uniprot id: Q21748
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F01G4.1
gene id: 6239:CELE_F01G4.1
uniprot id: G5EF53
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes (By similarity). The canonical SWI/SNF complex contains the catalytic subunit swsn-4, core subunits swsn-1 and swsn-5, and accessory subunits swsn-3, swsn-6, swsn-9, either phf-10 or dpff-1, and either ham-3/swsn-2.1 or swsn-2.2 (By similarity). BAF complexes additionally contain let-526, while PBAF complexes contain swsn-7 and pbrm-1 (By similarity). swsn-9 shows similarity to both BRD7 and BRD9, mammalian BAF and PBAF components respectively, and may be a component of both BAF and PBAF (Probable). Interacts (via Bromo domain) with histone H3 (via N-terminal tail mono-acetylated on 'Lys-15'); the interaction is direct (PubMed:34473995).
messages: In L1 larvae ubiquitously expressed (at protein level) (PubMed:11030341, PubMed:27207389). At later stages expressed in dividing vulval cells of the P lineage, hyp7 syncytia and ventral cord neurons (PubMed:11030341, PubMed:27207389). In L4 larvae expression declines substantially after completion of vulval induction (PubMed:27207389).
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) (By similarity). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Selectively binds the N-terminal tail of histone H3 mono-acetylated on 'Lys-15' via the C-terminal bromodomain (PubMed:34473995). Involved in multiple stages of somatic gonad development; as part of the PBAF complex, required for normal development of somatic gonadal precursor cells (the multipotent progenitors that give rise to all somatic tissues of the adult reproductive system), as part of the BAF complex, involved in the formation or function of the differentiated distal tip cells of the somatic gonad (PubMed:24402584). Influences vulval differentiation of P lineage cells, which may in part be mediated by its direct or indirect transcriptional regulation of let-23 (PubMed:27207389). Required during mitosis for asymmetric cell division of T blast cells (PubMed:11030341).
messages: Nucleus
messages: RNAi knockdown results in 100% embryonic lethality (PubMed:24402584). When RNAi is restricted to mesodermal cells of the MS, C and D lineages, which include the somatic gonadal precursor cells, results in gonadogenesis defects with increased expression of the head mesodermal cell marker arg-1 in somatic gonadal precursor cells (PubMed:24402584).
messages: The Bromo domain directly and selectively associates with the N-terminal tail of histone H3 mono-acetylated on 'Lys-15'.

6239:CELE T26C12.1
gene id: 6239:CELE_T26C12.1
uniprot id: O61856
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.
messages: Endoplasmic reticulum membrane

6239:CELE F52A8.6
gene id: 6239:CELE_F52A8.6
uniprot id: A0A1D3PCL3
uniprot id: A0A1D3PCM1
uniprot id: Q19143
names: Domain
names: Function
names: Similarity
messages: Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity.
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
messages: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Lys and Val residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

6239:CELE C11H1.2
gene id: 6239:CELE_C11H1.2
uniprot id: Q17912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

6239:CELE F53F10.3
gene id: 6239:CELE_F53F10.3
uniprot id: O01578
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: May mediate the uptake of pyruvate into mitochondria.
messages: Mitochondrion inner membrane

6239:CELE T04A8.7
gene id: 6239:CELE_T04A8.7
uniprot id: Q22137
uniprot id: Q86G92
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

6239:CELE T09A5.3
gene id: 6239:CELE_T09A5.3
uniprot id: P45963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Forms a homooligomeric channel blocked by alpha-bungarotoxin. The structure is probably pentameric (By similarity).
messages: Postsynaptic cell membrane

6239:CELE F54E7.1
gene id: 6239:CELE_F54E7.1
uniprot id: Q20787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Golgi apparatus membrane
messages: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).

6239:CELE B0025.2
gene id: 6239:CELE_B0025.2
uniprot id: O01422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN2 family.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-1, csn-3 and csn-4.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Nucleus

6239:CELE F12F6.6
gene id: 6239:CELE_F12F6.6
uniprot id: Q19371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R09B5.4
gene id: 6239:CELE_R09B5.4
uniprot id: O44607
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

6239:CELE F16B4.8
gene id: 6239:CELE_F16B4.8
uniprot id: A0A0K3ASE2
uniprot id: A0A0K3AXQ4
uniprot id: O44628
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.
messages: Required for intestinal cell division following the 16E cell stage of embryogenesis (PubMed:27104746). Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex (PubMed:27104746). Plays a role in male tail development, via regulation of the cell divisions of the ray precursor cell lineages, perhaps acting together with cell cycle regulators cyl-1, cdk-1, cyb-3, and cyd-1 (PubMed:27923661).
messages: Transiently expressed in the intestine during larval development (PubMed:27104746). Expressed in the intestine in L1 stage larvae, not expressed in L2 to L3 stage larvae, but is then again expressed in the gonad of L4 stage larvae (PubMed:27104746). Expressed in seam cells during larval development (PubMed:27923661). Broadly expressed throughout development in multiple male somatic tissues, including pharynx, ventral nerve cord, body muscles, diagonal muscles, and hypodermis (PubMed:27923661).
messages: Viable, but 85% of animals are sterile at 20 degrees Celsius (PubMed:27104746). Reduced number of intestinal cells in 1.5-fold stage embryos due to defective intestinal divisions and binuleations at the 16E cell stage of embryonic development (PubMed:27104746). Knockout with wee-1.3 RNAi suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746). RNAi-mediated knockdown causes abnormal male tail morphology; this phenotype is suppressed by simultaneous RNAi-mediated knockdown of wee-1.3 (PubMed:27923661).

6239:CELE F45F2.9
gene id: 6239:CELE_F45F2.9
uniprot id: E1B6Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

6239:CELE K08B4.3
gene id: 6239:CELE_K08B4.3
uniprot id: Q9TYY5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F53B1.8
gene id: 6239:CELE_F53B1.8
uniprot id: X5LPS1
uniprot id: X5LX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

6239:CELE F54A3.5
gene id: 6239:CELE_F54A3.5
uniprot id: Q9N4K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

6239:CELE C01G5.9
gene id: 6239:CELE_C01G5.9
uniprot id: Q9TXQ7
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C05D11.11
gene id: 6239:CELE_C05D11.11
uniprot id: P50432
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SHMT family.
messages: Homotetramer.
messages: Interconversion of serine and glycine.

6239:CELE K09E9.1
gene id: 6239:CELE_K09E9.1
uniprot id: A0A0K3AYL4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W05B5.3
gene id: 6239:CELE_W05B5.3
uniprot id: Q9XUK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y47H9C.6
gene id: 6239:CELE_Y47H9C.6
uniprot id: G5ECW5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Expressed in embryo and in larvae.
messages: Hatching is impaired in 5-6 percent of mutant embryos and about 2 percent of adults have uncoordinated movement (PubMed:18776901). In the anterior pharynx of L4 larvae, several cells including muscle and neuronal cells that normally survive during development are missing (PubMed:18776901). Slight increase in the number of cell corpses during embryonic development (PubMed:18776901). In a ced-5 n1812 or ced-6 n2095 mutant background, where cell corpse engulfment is defective, the number of cell corpses during embryonic development and in L1 larvae is further increased (PubMed:18776901). In a ced-3 n2427 or ced-3 n2427 and cps-3 n4872 mutant background, no extra pharyngeal cells caused by impaired apoptosis are produced (PubMed:23505386). In a csp-3 n4872, csp-1 n4967 and ced-3 n3692 mutant background, pharyngeal cells, that are normally fated to die, survive and 16 percent of animals have still 1 or more cell corpses that are morphologically apoptotic and are internalized by engulfing cells (PubMed:23505386). In addition, apoptosis of the male linker cell occurs normally (PubMed:23505386).
messages: Interacts with ced-3 (via large subunit p17); the interaction prevents ced-3 autoactivation.
messages: Non-catalytic caspase homolog which does not contain the region necessary for caspase activity (PubMed:9857046). Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4-induced ced-3 processing (PubMed:18776901). Has no effect on active ced-3 (PubMed:18776901). Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development (PubMed:18776901).

6239:CELE R04D3.1
gene id: 6239:CELE_R04D3.1
uniprot id: G5ED86
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T12D8.1
gene id: 6239:CELE_T12D8.1
uniprot id: G5EGI1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T10D4.4
gene id: 6239:CELE_T10D4.4
uniprot id: Q9TZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:KEF34 p01
gene id: 6239:KEF34_p01
uniprot id: P24896
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

6239:CELE T04C10.1
gene id: 6239:CELE_T04C10.1
uniprot id: Q8WQL7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Expressed in all somatic cells.
messages: First observed during early cell morphogenesis in the embryo, levels increase during later embryonic development and remain at comparable levels throughout larval and adult stages.
messages: No visible phenotype.
messages: Nucleus
messages: Possible role in the function of olfactory neurons.

6239:CELE C50H2.3
gene id: 6239:CELE_C50H2.3
uniprot id: G3MVG9
uniprot id: Q18761
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C16D9.6
gene id: 6239:CELE_C16D9.6
uniprot id: Q22900
names: Subcellular Location Annotation
messages: Membrane

6239:CELE D1014.3
gene id: 6239:CELE_D1014.3
uniprot id: Q18921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

6239:CELE F38E1.5
gene id: 6239:CELE_F38E1.5
uniprot id: P22454
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons (PubMed:25303524).

6239:CELE F52C12.6
gene id: 6239:CELE_F52C12.6
uniprot id: B5WWL2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

6239:CELE C08C3.2
gene id: 6239:CELE_C08C3.2
uniprot id: P34324
names: Function
names: Subunit
messages: Interacts with cul-3.
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

6239:CELE ZK75.3
gene id: 6239:CELE_ZK75.3
uniprot id: Q09628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE K02F3.2
gene id: 6239:CELE_K02F3.2
uniprot id: Q21153
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Binds to one calcium ion with high affinity.
messages: Homodimer (via N-terminus).
messages: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane
messages: Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain.

6239:CELE W04C9.1
gene id: 6239:CELE_W04C9.1
uniprot id: Q9TZD9
uniprot id: V6CLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

6239:CELE C02B10.3
gene id: 6239:CELE_C02B10.3
uniprot id: O44443
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K02G10.4
gene id: 6239:CELE_K02G10.4
uniprot id: Q21156
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons (PubMed:15236235). Flp-11 is expressed in the DD, VD and DVB motor neurons, the PVC and URX interneurons, and the AUA, BAG, DA, LUA, and SAB neurons (PubMed:15236235). Also expressed in head muscle, socket or sheath cells and uterine cells (PubMed:15236235). Expressed exclusively in PHC sensory neurons in males (PubMed:15236235, PubMed:28065609).
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults (PubMed:9685599). In males, highly expressed in PHC sensory neurons during the L4 larval stage (PubMed:28065609).
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system (PubMed:16187307). Acts as a ligand for the npr-22 receptor in vitro (PubMed:16377032).
messages: Secreted

6239:CELE F13D12.4
gene id: 6239:CELE_F13D12.4
uniprot id: P52713
uniprot id: Q7JMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homodimer.
messages: Homotetramer.
messages: Mitochondrion
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
messages: Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.

6239:CELE F58E10.5
gene id: 6239:CELE_F58E10.5
uniprot id: Q9XUW7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W02B12.10
gene id: 6239:CELE_W02B12.10
uniprot id: Q23126
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Nucleus

6239:CELE T01G6.6
gene id: 6239:CELE_T01G6.6
uniprot id: B1GRK7
uniprot id: H2L0I0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK1248.19
gene id: 6239:CELE_ZK1248.19
uniprot id: Q7JPD8
names: Similarity
messages: Belongs to the CTNNBIP1 family.

6239:CELE F15A4.3
gene id: 6239:CELE_F15A4.3
uniprot id: O17818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F54D1.5
gene id: 6239:CELE_F54D1.5
uniprot id: Q20766
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F20B10.1
gene id: 6239:CELE_F20B10.1
uniprot id: Q19617
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Cell membrane
messages: Expressed during all stages of larval development and adulthood (at protein level) (PubMed:21055481). Expressed during embryogenesis (PubMed:33238150). Expressed in EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis (PubMed:33238150).
messages: Highly expressed in pharyngeal g1 and g2 gland cells, pharyngeal muscle cells and the unilateral GABAergic RIS interneuron (at protein level) (PubMed:21055481). Expressed in pm5 pharyngeal muscle cells and the nerve ring (PubMed:33238150).
messages: Interacts (via the intracellular domain) with F-actin; the interaction is required for anchoring F-actin at the membrane for gap junction formation.
messages: RNAi-mediated knockdown results in abherrent inx-3-positive gap junction formation along the adjoining membranes of EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis, and in adult pharyngeal muscles (PubMed:33238150). The inx-3-positive gap junctions are increased in number, are randomly positioned at irregular intervals on either the EA and EP cells and, although they are along the membrane, they are not on the membrane (PubMed:33238150). Furthermore, F-actin does not accumulate at the gap junction formation plaque in between the EA and EP adjoining membrane, but randomly forms patches along the membrane (PubMed:33238150). RNAi-mediated knockdown does not affect the expression of inx-3 (PubMed:33238150). RNAi-mediated knockdown impairs gap junction function in pharyngeal muscles which disrupts the synchronized muscle contraction between the pharyngeal metacorpus and terminal bulbs and thereby decreases the pharyngeal pumping rate (PubMed:33238150). RNAi-mediated knockdown in the nerve ring results in uncoordinated movements (also known as an unc phenotype), decreased locomotion and defective unc-9-positive gap junction formation and morphology (PubMed:33238150).
messages: Required for gap junction formation, playing a role in anchoring the cytoskeletal component F-actin to the membrane of adjacent cells and thus facilitating the formation of gap junction channels in embryonic cells, muscle cells and neuronal cells (PubMed:33238150). Plays a role in maintaining gap junction activity to promote pharyngeal muscle contraction (PubMed:33238150).
messages: gap junction

6239:CELE Y71F9AL.18
gene id: 6239:CELE_Y71F9AL.18
uniprot id: A0A0K3ARD5
uniprot id: Q9N4H4
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Inhibited by N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide HCl (PJ34), 1,5-dihydroxyisoquinoline (DHQ) and 3-aminobenzamide (3AB).
messages: Nucleus
messages: Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death (PubMed:15923155). Involved in protection of the genome against mutations (PubMed:12600937).
messages: Predominantly expressed at early embryonic stages and later in L4 and adult stages.

6239:CELE T19H12.9
gene id: 6239:CELE_T19H12.9
uniprot id: O01614
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C15C8.3
gene id: 6239:CELE_C15C8.3
uniprot id: Q18020
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aspartic protease which plays a role in heme homeostasis and mediates inter-organ signaling between the intestine and extra-intestinal tissues when cellular heme levels are low.
messages: Belongs to the peptidase A1 family.
messages: By heme deficiency.
messages: Proteolytically cleaved.
messages: RNAi-mediated knockdown in larvae results in defective heme accumulation in the intestine under low heme conditions (PubMed:28581477). Double RNAi-mediated knockdown with hrg-4 or mrp-5 in larvae results in defective heme sensing (PubMed:28581477).
messages: Secreted
messages: Synthesized in the intestine (PubMed:28581477). When secreted in low heme conditions, localizes to neurons near the anterior and posterior regions of the body and in coelomocytes (PubMed:28581477).

6239:CELE F59C12.2
gene id: 6239:CELE_F59C12.2
uniprot id: G5ECV2
uniprot id: O17470
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE R151.2
gene id: 6239:CELE_R151.2
uniprot id: Q21994
uniprot id: Q6AHR3
uniprot id: Q95QB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

6239:CELE C01B4.7
gene id: 6239:CELE_C01B4.7
uniprot id: A0A0M7RFG7
uniprot id: G5EDZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0286.3
gene id: 6239:CELE_B0286.3
uniprot id: Q10457
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

6239:CELE ZK809.4
gene id: 6239:CELE_ZK809.4
uniprot id: F5GU99
uniprot id: G5EDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE Y50D7A.9
gene id: 6239:CELE_Y50D7A.9
uniprot id: Q965T4
names: Similarity
messages: Belongs to the TACO1 family.

6239:CELE C04F5.6
gene id: 6239:CELE_C04F5.6
uniprot id: Q9GZD2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C08G9.2
gene id: 6239:CELE_C08G9.2
uniprot id: O44131
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C06B3.3
gene id: 6239:CELE_C06B3.3
uniprot id: G5ECD0
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE W07E6.3
gene id: 6239:CELE_W07E6.3
uniprot id: Q9TYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

6239:CELE T23D8.2
gene id: 6239:CELE_T23D8.2
uniprot id: Q9XVI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE F25H2.13
gene id: 6239:CELE_F25H2.13
uniprot id: Q93575
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus
messages: Viable, although the brood size is reduced and the life cycle is retarded (at 20 degrees Celsius, worms take 24 hours longer to reach the gravid adult stage). The smaller brood size may result from replicative stress, which is often associated with a persistence of unrepaired DNA damage during development. Mutants show defective crossover interference with all double-strand breaks becoming crossovers and a compromised homeostasis after ionizing radiation. Synthetic lethality in worms lacking both rtel-1 and him-6, with a marked increase in the number of foci representing unresolved recombination intermediates.

6239:CELE R06F6.8
gene id: 6239:CELE_R06F6.8
uniprot id: Q09417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC1 family.
messages: Component of a guanine nucleotide exchange factor (GEF) complex.
messages: Membrane
messages: Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.

6239:CELE Y94A7B.11
gene id: 6239:CELE_Y94A7B.11
uniprot id: A8DZ48
names: Function
names: Similarity
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

6239:CELE F53G12.5
gene id: 6239:CELE_F53G12.5
uniprot id: H2L067
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE F39H11.2
gene id: 6239:CELE_F39H11.2
uniprot id: B2D6P4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: May be a general transcription factor (PubMed:11030350, PubMed:11030349). Plays an essential role for RNA polymerase II/ama-1 transcription in early embryos whereby it activates a subset of RNA polymerase II promoters and facilitates the reestablishment of transcription after mitosis (PubMed:14726532).
messages: Nucleus
messages: RNAi-mediated knockdown causes early embryonic defects, including premature cell division of the Ea and Ep blastomeres, a failure to undergo gastrulation, and embryonic arrest (PubMed:11030350, PubMed:11030349). Knockdown causes severe loss of polymerase II large subunit ama-1 phosphorylation (PubMed:11030350, PubMed:11030349). Knockdown also causes a reduction in expression levels of several embryonic genes (PubMed:11030350, PubMed:11030349, PubMed:14726532).
messages: Widely expressed throughout embryogenesis, starting at the two-cell stage and probably expressed both maternally and zygotically (at protein level).

6239:CELE F16H6.1
gene id: 6239:CELE_F16H6.1
uniprot id: Q9XV91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F13H10.3
gene id: 6239:CELE_F13H10.3
uniprot id: Q19425
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transport is sodium-dependent (By similarity). Transport of leucine, tyrosine and phenylalanine is increased by arginine binding (By similarity).
messages: Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
messages: Late endosome membrane
messages: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.
messages: Lysosome membrane

6239:CELE C37H5.14
gene id: 6239:CELE_C37H5.14
uniprot id: A0A0K3ASB8
uniprot id: A0A0K3AUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE B0395.1
gene id: 6239:CELE_B0395.1
uniprot id: G5EDH8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

6239:CELE K07A1.6
gene id: 6239:CELE_K07A1.6
uniprot id: P90911
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C56E10.4
gene id: 6239:CELE_C56E10.4
uniprot id: B3WFU1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R11.1
gene id: 6239:CELE_R11.1
uniprot id: O62347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE F23H11.9
gene id: 6239:CELE_F23H11.9
uniprot id: O01916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
messages: Mitochondrion inner membrane

6239:CELE F08B12.3
gene id: 6239:CELE_F08B12.3
uniprot id: B2MZB8
uniprot id: G5ECD1
uniprot id: G5EDJ1
uniprot id: H9G2R3
uniprot id: H9G2R4
uniprot id: H9G2R6
uniprot id: H9G2R7
uniprot id: Q565B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE W02A2.9
gene id: 6239:CELE_W02A2.9
uniprot id: Q52GX7
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE Y63D3A.4
gene id: 6239:CELE_Y63D3A.4
uniprot id: Q9XWG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily.
messages: Binds 1 magnesium or manganese ion per subunit.
messages: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals.
messages: Nucleus
messages: PML body

6239:CELE C34F11.4
gene id: 6239:CELE_C34F11.4
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F45H10.2
gene id: 6239:CELE_F45H10.2
uniprot id: O45525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE F58H12.1
gene id: 6239:CELE_F58H12.1
uniprot id: Q21017
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated. Elevated cAMP levels appears to act via PKA to directly or indirectly phosphorylate multiple sites on kin-29 and inhibit function.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. Exhibit defects in food-induced quiescence behavior.
messages: Expressed throughout all stages of postembryonic development. Observed in the intestine and in cells in the tail during L1, L3 and L4.
messages: Interacts with tax-6.
messages: Nucleus
messages: Primarily neuronal, with additional expression in body wall muscle and hypodermal cells. Among neuronal cells, expressed in multiple sensory neurons and interneurons in the lateral, anterior, and lumbar ganglia, as well as in motor neurons in the ventral motor cord. Present in the AWB and AWC olfactory neurons.
messages: Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.

6239:CELE T09B9.1
gene id: 6239:CELE_T09B9.1
uniprot id: Q7JMM5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

6239:CELE C46H11.7
gene id: 6239:CELE_C46H11.7
uniprot id: Q9GYJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F09E5.17
gene id: 6239:CELE_F09E5.17
uniprot id: Q8IG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

6239:CELE C44E4.6
gene id: 6239:CELE_C44E4.6
uniprot id: O01805
names: Function
names: Similarity
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.

6239:CELE F10D2.3
gene id: 6239:CELE_F10D2.3
uniprot id: A0A0B7H0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE K07H8.1
gene id: 6239:CELE_K07H8.1
uniprot id: Q20068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

6239:CELE Y102A11A.6
gene id: 6239:CELE_Y102A11A.6
uniprot id: Q95XJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane

6239:CELE C15F1.7
gene id: 6239:CELE_C15F1.7
uniprot id: P34697
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Protects cells against oxidative stress by converting superoxide radicals to hydrogen peroxide (PubMed:16234242). Required for normal brood size (PubMed:18073424). May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation (PubMed:20380830).
messages: The insertion of copper which activates the protein requires glutathione. This is independent of copper chaperone for SOD1 (CCS), which activates orthologs.
messages: Worms exhibit increased oxidative stress and reduced brood size (PubMed:18073424). RNAi-mediated knockdown suppresses the slow germline development and the delayed egg-production of clk-1 mutants (PubMed:14657502). RNAi-mediated knockdown causes an increase in the number of oocytes with mpk-1 phosphorylation (PubMed:20380830).

6239:CELE E03G2.3
gene id: 6239:CELE_E03G2.3
uniprot id: G5EFQ9
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE R06A4.4
gene id: 6239:CELE_R06A4.4
uniprot id: A0A131MBF9
uniprot id: O62332
uniprot id: O62333
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F54D7.2
gene id: 6239:CELE_F54D7.2
uniprot id: O44732
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

6239:CELE F38E11.5
gene id: 6239:CELE_F38E11.5
uniprot id: Q20168
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Embryonic death and abnormal oocytes.
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

6239:CELE ZC482.8
gene id: 6239:CELE_ZC482.8
uniprot id: Q86D06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C46H11.2
gene id: 6239:CELE_C46H11.2
uniprot id: Q9GYJ1
names: Similarity
messages: Belongs to the FMO family.

6239:CELE ZK993.1
gene id: 6239:CELE_ZK993.1
uniprot id: Q9N4L2
uniprot id: V6CJ20
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0238.10
gene id: 6239:CELE_B0238.10
uniprot id: O16486
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

6239:CELE B0331.1
gene id: 6239:CELE_B0331.1
uniprot id: O45219
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE H16O14.1
gene id: 6239:CELE_H16O14.1
uniprot id: C0KDV0
uniprot id: G5EEC9
uniprot id: H2KZC2
uniprot id: H2KZC3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C37A2.6
gene id: 6239:CELE_C37A2.6
uniprot id: O01503
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. ETFBKMT family.
messages: Probable methyltransferase.

6239:CELE T09A12.4
gene id: 6239:CELE_T09A12.4
uniprot id: H2KYJ8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Interacts with nuclear hormone receptor nhr-49; the interaction is direct.
messages: Nucleus
messages: RNAi-mediated knockdown increases expression of potassium channel accessory subunit mps-2 and suppresses age-dependent memory decline.
messages: Transcription factor (PubMed:33259792). Binds to regulatory elements and regulates transcription of target genes, including the potassium channel accessory subunit mps-2 (PubMed:33259792). Negatively regulates transcription of mps-2, thereby modulating age-dependent memory decline (PubMed:33259792). In concert with nuclear hormone receptor nhr-49, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling (PubMed:22511885). Plays a role in modulating mitochondrial morphology and function (PubMed:22511885).
messages: Widely expressed, including in hypodermis, gut, muscle, and neuronal cells of the ventral nerve chord, head, and tail ganglia (PubMed:33259792). Expressed in the head ganglion in several sensory and interneurons, including AVA (PubMed:33259792).

6239:CELE F10G7.1
gene id: 6239:CELE_F10G7.1
uniprot id: Q19329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
messages: Required during maturation of the 40S ribosomal subunit in the nucleolus.
messages: nucleolus

6239:CELE F13A2.8
gene id: 6239:CELE_F13A2.8
uniprot id: O16890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE W03G9.2
gene id: 6239:CELE_W03G9.2
uniprot id: O44749
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in germ cells of L4 larvae (PubMed:33231880). Expressed at high levels in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880).
messages: May interact with pid-2, app-1 and prmt-5.
messages: P-body
messages: Together with pid-5, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-5, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-5, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-5, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880).
messages: perinuclear region

6239:CELE C06A1.3
gene id: 6239:CELE_C06A1.3
uniprot id: P48458
names: Cofactor
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.

6239:CELE ZK858.6
gene id: 6239:CELE_ZK858.6
uniprot id: B3WFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

6239:CELE T06A4.1
gene id: 6239:CELE_T06A4.1
uniprot id: H2L0K5
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE D2024.6
gene id: 6239:CELE_D2024.6
uniprot id: P34685
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

6239:CELE T03E6.6
gene id: 6239:CELE_T03E6.6
uniprot id: O45739
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE W01A11.3
gene id: 6239:CELE_W01A11.3
uniprot id: Q23064
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cargo-specific adapter that is involved in nuclear migration during development and thereafter (PubMed:11748140, PubMed:19605495, PubMed:20005871, PubMed:20921138, PubMed:27697906). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402, PubMed:25023515). Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations (PubMed:19605495, PubMed:20921138). Moreover, within the complex, also recruits the large microtubule-associated bicd-1-dlc-1-egal-1 and lis-1-nud-2 complexes to the nuclear envelope to regulate both the bidirectional migration of nuclei and the extent of nuclear migrations (PubMed:20005871). Not required for centrosome attachment to the nucleus (PubMed:11748140).
messages: Component of the unc-83-unc-84 LINC complex which contains at least unc-83 and unc-84 (PubMed:11748140, PubMed:16481402). Within the unc-83-unc-84 LINC complex interacts with unc-84 (via C-terminus); the interaction is probably required to recruit unc-83 to the nuclear envelope where it then recruits dynein and kinesin-1 complexes to regulate nuclear migration (PubMed:11748140, PubMed:16481402). Interacts with bicd-1 and dlc-1 (PubMed:20005871). Interacts with nud-2 (via C-terminus); the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871). Interacts with klc-2; the interaction is direct (PubMed:19605495).
messages: Expressed in embryos and adults (PubMed:11748140). First expressed at the nuclear envelope of migrating hyp7 nuclei, then, at the bean embryonic stage, it is expressed in hyp7 cells, P cells and intestinal cells (PubMed:11748140).
messages: Nucleus membrane
messages: Nucleus outer membrane
messages: Predominantly expressed in migratory nuclei (PubMed:11748140). Expressed in a variety of cell-types, including cells around the pharynx and in the uterus (PubMed:11748140).
messages: The KASH domain, which contains a transmembrane domain, mediates nuclear envelope targeting.
messages: Viable, but with failed nuclear migrations in hyp7 hypodermal precursor cells (PubMed:11748140, PubMed:16481402, PubMed:19605495, PubMed:20005871, PubMed:20921138). Hyp7 nuclei are mislocalized to the dorsal cord of L1 stage larvae (PubMed:19605495).

6239:CELE F11A10.2
gene id: 6239:CELE_F11A10.2
uniprot id: Q19335
names: Similarity
messages: Belongs to the SF3A2 family.

6239:CELE Y70G10A.2
gene id: 6239:CELE_Y70G10A.2
uniprot id: Q9XWC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C31H2.1
gene id: 6239:CELE_C31H2.1
uniprot id: Q8MQB0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C47F8.3
gene id: 6239:CELE_C47F8.3
uniprot id: G5ECA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE JC8.5
gene id: 6239:CELE_JC8.5
uniprot id: Q95QD5
uniprot id: S6F574
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

6239:CELE W03A5.2
gene id: 6239:CELE_W03A5.2
uniprot id: Q23135
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0564.2
gene id: 6239:CELE_B0564.2
uniprot id: A0A061AJK0
uniprot id: Q17527
names: Similarity
messages: Belongs to the alkB family.

6239:CELE F48G7.5
gene id: 6239:CELE_F48G7.5
uniprot id: O44585
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F45E4.1
gene id: 6239:CELE_F45E4.1
uniprot id: Q94231
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by GTPase-activating protein (GAP) (By similarity).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Golgi apparatus membrane
messages: Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity).

6239:CELE F40A3.3
gene id: 6239:CELE_F40A3.3
uniprot id: A0A0K3ASH2
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

6239:CELE C50H2.6
gene id: 6239:CELE_C50H2.6
uniprot id: Q18764
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R07H5.10
gene id: 6239:CELE_R07H5.10
uniprot id: G5EFX5
uniprot id: G5EGQ7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C10G8.4
gene id: 6239:CELE_C10G8.4
uniprot id: Q94162
names: Subcellular Location Annotation
messages: Secreted

6239:CELE Y37D8A.18
gene id: 6239:CELE_Y37D8A.18
uniprot id: Q9XWV5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Induction of dauer formation and larval arrest. Reduced insulin/IGF signaling.
messages: Mitochondrion
messages: Ribosomal protein required for normal mitochondrial function and normal larval development. Thought to have a role in insulin/IGF signaling.

6239:CELE Y17G7B.5
gene id: 6239:CELE_Y17G7B.5
uniprot id: Q9XXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

6239:CELE F28H7.9
gene id: 6239:CELE_F28H7.9
uniprot id: Q19897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C09G12.1
gene id: 6239:CELE_C09G12.1
uniprot id: O44462
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F52E10.5
gene id: 6239:CELE_F52E10.5
uniprot id: Q21065
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures.
messages: Expressed in embryos and larvae. Not expressed in adults.
messages: Expressed in the embryonic and larval hypodermis. Also expressed in the ventral nerve cord of larvae.
messages: Forms some heteromeric filaments with ifb-1.

6239:CELE Y73E7A.2
gene id: 6239:CELE_Y73E7A.2
uniprot id: Q9GUM5
names: Similarity
messages: Belongs to the AATF family.

6239:CELE Y42H9B.2
gene id: 6239:CELE_Y42H9B.2
uniprot id: Q9N3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sidekick family.
messages: Cell adhesion protein.
messages: Membrane

6239:CELE W02D9.1
gene id: 6239:CELE_W02D9.1
uniprot id: D7SFP4
uniprot id: O02334
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
messages: Heterodimer of a small subunit and a large subunit.

6239:CELE Y71G12B.12
gene id: 6239:CELE_Y71G12B.12
uniprot id: Q3V5I7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to lgg-3/ATG12; which is essential for autophagy.
messages: Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane (PubMed:24185444). Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable). Furthermore, association with atg-16.2 is required for the nucleation of lgg-1 positive autophagic vesicles (PubMed:24185444).
messages: Most likely a component of a complex at least containing atg-5, lgg-3/ATG12, atg-16.1 and/or atg-16.2 (Probable). Interacts with lgg-3/ATG12 (By similarity). Interacts with atg-16.1 (via N-terminus) and atg-16.2 (via N-terminus) (PubMed:24185444).
messages: Preautophagosomal structure membrane

6239:CELE T16G12.5
gene id: 6239:CELE_T16G12.5
uniprot id: Q22528
names: Similarity
messages: Belongs to the Tango6 family.

6239:CELE C03G6.5
gene id: 6239:CELE_C03G6.5
uniprot id: O01454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0376 family.
messages: Secreted

6239:CELE F59B10.3
gene id: 6239:CELE_F59B10.3
uniprot id: Q09951
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T27E4.9
gene id: 6239:CELE_T27E4.9
uniprot id: P02513
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE T05D4.5
gene id: 6239:CELE_T05D4.5
uniprot id: O45751
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZK75.1
gene id: 6239:CELE_ZK75.1
uniprot id: Q09626
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed by ASI and ASJ sensory neurons and weakly by ventral cord motor neurons.
messages: Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions (PubMed:23665919). Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions (PubMed:24671950).
messages: Secreted

6239:CELE K07C5.8
gene id: 6239:CELE_K07C5.8
uniprot id: G5EE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

6239:CELE C30A5.7
gene id: 6239:CELE_C30A5.7
uniprot id: P13528
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-4 subfamily.
messages: First appears during embryogenesis and persists throughout adulthood.
messages: In a number of neuronal cell lineages, one of the two daughter cells of a division fails to assume its normal fate, retaining instead the fate of its parent cell. Altered gene expression in a number of neuron types including reduced cat-1 expression in AIM, NSM, HSN and RIH neurons, loss of cat-4 expression in HSN neurons, loss of expression of dop-3 and mgl-3 and reduced expression of bas-1, nlp-13, ptpa-1 and scd-2 in NSM neurons, loss of expression of gcy-19, klp-6, lag-2 and unc-17 and reduced expression of cho-1 and unc-5 in IL2 neurons, and loss of tph-1 expression in AIM, NSM, HSN and RIH neurons which leads to defects in serotonin production. Defective motility along with defects in IL2Q dendritic arborization and nictation. Abnormal neurite outgrowth in NSM neurons. Defective response to odor attractants but odor repellants are avoided normally. Penetrant ventral axon growth defects in HSN motor neurons with extension of processes in L1, three stages earlier than wild-type. Incorrect unc-40 localization. Defective egg-laying characterized by retention of substantially more eggs in the uterus of second-day animals than the wild-type.
messages: Interacts with mec-3; the heterooligomer binds to the promoters of mec-3, mec-4 and mec-7.
messages: Nucleus
messages: Specific to neurons and neuroblasts. Expressed in CEM head neurons and in IL2, URA, URB, URX and URY neurons. Not expressed in olfactory sensory neurons but expressed in AIZ interneurons.
messages: Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions (PubMed:7237544, PubMed:2257628, PubMed:26096732, PubMed:10899123). Involved in sensory neuron production and function (PubMed:1361171, PubMed:9735371, PubMed:10899123, PubMed:26096732). Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation (PubMed:1361171, PubMed:9735371). In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function (PubMed:9735371, PubMed:10899123). Involved in determining the identity of the serotonergic NSM neurons and the cholinergic IL2 sensory and URA motor neurons (PubMed:24353061). Promotes expression of the cfi-1 transcription factor in the URA and IL2 neurons which in turn activates normal URA and IL2 gene expression (PubMed:24353061, PubMed:11959845). Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 (PubMed:26096732). Regulates expression of a number of genes in NSM neurons including bas-1, cat-1, dop-3, mgl-3, nlp-13, scd-2 and ptps-1 (PubMed:24353061). In the IL2 neurons, required for expression of cho-1, gcy-19, klp-6, lag-2, unc-5 and unc-17 (PubMed:24353061). Promotes expression of pkd-2 in the male-specific CEM head neurons (PubMed:11959845). Required for dauer-specific branching of IL2Q neurons and nictation behavior (PubMed:23932402). Controls both the timing and direction of axon outgrowth in HSN neurons (PubMed:21656875). Plays a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthe…

6239:CELE F57B10.12
gene id: 6239:CELE_F57B10.12
uniprot id: O44740
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline.
messages: Highly expressed in the female germline.
messages: Interacts with mei-1.
messages: spindle pole

6239:CELE T13H5.7
gene id: 6239:CELE_T13H5.7
uniprot id: Q9U6P6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

6239:CELE H23N18.2
gene id: 6239:CELE_H23N18.2
uniprot id: Q9TXZ5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C15F1.4
gene id: 6239:CELE_C15F1.4
uniprot id: P80361
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

6239:CELE T08B2.9
gene id: 6239:CELE_T08B2.9
uniprot id: Q9GYS8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

6239:CELE C06G8.2
gene id: 6239:CELE_C06G8.2
uniprot id: Q17758
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Expressed in vulval, pharyngeal and anal muscles.
messages: Gradual increase in expression during development from embryo through to adult with highest levels of expression in the late larval and adult stages.
messages: Membrane
messages: Proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides. Transport is independent of sodium and chloride ions. Protein shows high affinity to peptide substrates.

6239:CELE F28F8.1
gene id: 6239:CELE_F28F8.1
uniprot id: G5EG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE K12D12.3
gene id: 6239:CELE_K12D12.3
uniprot id: Q21437
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C31E10.7
gene id: 6239:CELE_C31E10.7
uniprot id: Q93315
names: Similarity
messages: Belongs to the cytochrome b5 family.

6239:CELE C44C3.5
gene id: 6239:CELE_C44C3.5
uniprot id: Q8IFY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C35D10.1
gene id: 6239:CELE_C35D10.1
uniprot id: Q8WQG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC7 family.
messages: Membrane

6239:CELE F36D4.2
gene id: 6239:CELE_F36D4.2
uniprot id: Q20100
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

6239:CELE Y37E3.9
gene id: 6239:CELE_Y37E3.9
uniprot id: Q9BKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prohibitin family.
messages: High molecular weight complex that consist of phb-1 and phb-2.
messages: Mitochondrion inner membrane
messages: PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells.

6239:CELE CTEL55X.1
gene id: 6239:CELE_CTEL55X.1
uniprot id: A4F305
uniprot id: H2KY55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

6239:CELE W02B12.9
gene id: 6239:CELE_W02B12.9
uniprot id: Q23125
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Expressed in a variety of tissues from embryo to adult.
messages: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown results in smaller, but normally-proportioned animals that are paler and thinner as compared to wild-type, a reduced growth rate, slow movements with a 35% decrease in the number of body bends per 20 seconds, reduced brood size, increased lifespan and inceased sensitivity to the oxidative stress inducer paraquat (PubMed:22253756). RNAi-mediated knockdown results in increased lifespan (PubMed:22253756, PubMed:25769692).

6239:CELE C13F10.4
gene id: 6239:CELE_C13F10.4
uniprot id: O01485
names: Similarity
messages: Belongs to the HEATR5 family.

6239:CELE C09C7.1
gene id: 6239:CELE_C09C7.1
uniprot id: G5ECB1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the L1 larval stage, display defects in the positioning of the ventral nerve cord (VNC) axons characterized by axons of embryonically generated PVQ and PVP neurons, but not of RMEV, HSN and AVK neurons, from the left and right VNC drifting into the opposite cord (axon flip-over) (PubMed:11809975, PubMed:19737747). These defects are not enhanced in a zig-3 (tm924) mutant background or in zig-3 (tm924) dig-1 (ky188), zig-3 (tm924) sax-7 (nj48) or zig-3 (tm924) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1, zig-2, zig-3 or zig-5 or zig-8 mutant background, cell body positioning of ASI and ASH head neurons is normal (PubMed:22829780).
messages: Expressed in PVT, ASK, BAG, M2 and ASI neurons. In L1 larvae, expressed in pharyngeal ectoderm and mesoderm.
messages: Expression begins at the late L1 larval stage.
messages: Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.
messages: Secreted

6239:CELE C06G8.4
gene id: 6239:CELE_C06G8.4
uniprot id: Q17760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F22A3.2
gene id: 6239:CELE_F22A3.2
uniprot id: Q19694
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE K03H1.4
gene id: 6239:CELE_K03H1.4
uniprot id: P34500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F47B10.7
gene id: 6239:CELE_F47B10.7
uniprot id: Q20507
names: Function
names: Similarity
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.

6239:CELE C16A3.1
gene id: 6239:CELE_C16A3.1
uniprot id: Q8MNV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA.
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

6239:CELE Y65B4BL.5
gene id: 6239:CELE_Y65B4BL.5
uniprot id: Q9N302
uniprot id: V6CLI5
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

6239:CELE ZK377.2
gene id: 6239:CELE_ZK377.2
uniprot id: G5EBF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. ROBO/SAX3 family.
messages: Expressed in the AVG interneuron and the male-specific sensory neuron HOA.
messages: Membrane
messages: Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance.

6239:CELE ZK1248.6
gene id: 6239:CELE_ZK1248.6
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F44C4.5
gene id: 6239:CELE_F44C4.5
uniprot id: Q20390
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Removes thioester-linked fatty acyl groups such as palmitate (hexadecanoate) from modified cysteine residues in proteins or peptides.
messages: Worms exhibit a developmental delay and mild reproductive defects. They have abnormal mitochondria in muscle and neuronal cells.

6239:CELE W02B12.7
gene id: 6239:CELE_W02B12.7
uniprot id: Q23124
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE Y51A2D.19
gene id: 6239:CELE_Y51A2D.19
uniprot id: H7BRC9
uniprot id: H7BRM4
uniprot id: H7BRM5
uniprot id: H7BRM7
uniprot id: H8ESD6
uniprot id: H8ESD8
uniprot id: H8ESE2
uniprot id: H8ESE3
uniprot id: H8ESE4
uniprot id: H8ESE5
uniprot id: Q95V25
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. Slo sub-subfamily.
messages: Cell membrane
messages: Expressed in synaptic regions of the nervous system including in both the nerve ring and nerve cords, as well as in the body-wall and vulval muscle.
messages: Homotetramer; which constitutes the calcium-activated potassium channel.
messages: Its activity is activated by ethanol, leading to the inhibition of neuronal activity.
messages: Membrane
messages: Phosphorylated.
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:11738032). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane (PubMed:11738032). It therefore contributes to repolarization of the membrane potential (PubMed:11738032). Essential for the regulation of neurotransmitter release at synapses (PubMed:11738032, PubMed:28168949).
messages: Synapse
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site.
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).

6239:CELE R05F9.10
gene id: 6239:CELE_R05F9.10
uniprot id: Q21746
names: Similarity
messages: Belongs to the SGT family.

6239:CELE T26E3.9
gene id: 6239:CELE_T26E3.9
uniprot id: O17847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE ZC395.6
gene id: 6239:CELE_ZC395.6
uniprot id: G5EBS1
names: Similarity
messages: Belongs to the IPP transferase family.

6239:CELE T02C12.2
gene id: 6239:CELE_T02C12.2
uniprot id: Q22092
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE F18C5.8
gene id: 6239:CELE_F18C5.8
uniprot id: Q19552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE T01D3.3
gene id: 6239:CELE_T01D3.3
uniprot id: P90956
uniprot id: Q7JL02
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

6239:CELE C07G2.2
gene id: 6239:CELE_C07G2.2
uniprot id: Q86MD3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family.
messages: Chromosome
messages: Expressed in intestinal cells.
messages: Interacts with serine/threonine kinase pmk-1; perhaps in a manner dependent on dual specificity protein kinase sek-1.
messages: Nucleus
messages: RNAi-mediated knockdown increases susceptibility to infection by the Gram-negative bacterium P.aeruginosa (PubMed:20369020). Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).
messages: Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses (PubMed:20369020, PubMed:28632756, PubMed:30789901). Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901). Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381). Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901). May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853). May be phosphorylated by pmk-1 (PubMed:20369020). Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).

6239:CELE Y41D4B.8
gene id: 6239:CELE_Y41D4B.8
uniprot id: Q95Y07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK1127.7
gene id: 6239:CELE_ZK1127.7
uniprot id: G5ECQ8
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the type II topoisomerase family.
messages: Lacks the conserved ATP binding sites, the conserved active site tyrosine at position 404, the conserved isoleucine at position 455 important for DNA bending, and the conserved magnesium binding site at position 143, and therefore probably lacks topoisomerase activity.
messages: Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution.
messages: RNAi-mediated knockdown leads to impaired removal of the cohesin component scc-1 from kinetochores on mitotic metaphase chromosomes.

6239:CELE C18B12.2
gene id: 6239:CELE_C18B12.2
uniprot id: G5EBF7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C33F10.12
gene id: 6239:CELE_C33F10.12
uniprot id: Q18390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE F46H5.4
gene id: 6239:CELE_F46H5.4
uniprot id: Q20487
names: Similarity
messages: Belongs to the DOCK family.

6239:CELE ZK652.2
gene id: 6239:CELE_ZK652.2
uniprot id: P34660
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom7 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane

6239:CELE F40F4.6
gene id: 6239:CELE_F40F4.6
uniprot id: A0A131MBU3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed in the posterior cells of the intestine in L4 larva.
messages: Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity.
messages: RNAi-mediated knockdown in larvae results in reduced survival following infection with the pathogenic bacterium P.luminescens. RNAi-mediated knockdown in a glp-1 e2141 mutant background (in which germ cells are deleted) rescues the increased lifespan phenotype of the glp-1 mutant.
messages: Secreted
messages: Up-regulated following infection with P.luminescens subsp Hb and E.faecalis bacteria.

6239:CELE Y18H1A.13
gene id: 6239:CELE_Y18H1A.13
uniprot id: Q1EPL5
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y71G12B.23
gene id: 6239:CELE_Y71G12B.23
uniprot id: C0VXV9
uniprot id: H2KZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE C14B9.4
gene id: 6239:CELE_C14B9.4
uniprot id: P34331
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Embryos.
messages: Impaired protein polarity (PubMed:18316412, PubMed:20823068). Lengthened AB and P1 cell cycle times (PubMed:18316412, PubMed:20823068). RNAi-mediated knockdown causes defects in germline mitosis including cell-cylce arrest and formation of polyploid nuclei (PubMed:22018922). RNAi-mediated knockdown in plk-2 mutant background causes a loss in sun-1 phosphorylation at 'Ser-8' but not at 'Ser-12' (PubMed:22018922).
messages: Interacts with mex-5, mex-6 and spat-1.
messages: Midbody
messages: Nucleus
messages: Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca (PubMed:10660671). In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes (PubMed:10660671). Zygotic role in the development of the germline and nerve cord (PubMed:10660671). In mitotic cells, plays a role in spindle organization and centrosome maturation (PubMed:20823068). Involved in asymmetric nuclear localization of cdc-25.1 during embryogenesis which affects cell division timing (PubMed:18305005, PubMed:18316412, PubMed:20823068). Together with plk-2, regulates cytoplasm polarity in early embryos (PubMed:18199581, PubMed:18316412, PubMed:18305005). May play a minor role in chromosome pairing and synapsis during oocyte meiosis I (PubMed:22018922).
messages: The POLO box domains are involved in the asymmetric cytoplasmic localization.
messages: centrosome
messages: kinetochore

6239:CELE C28G1.3
gene id: 6239:CELE_C28G1.3
uniprot id: Q18286
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE ZK185.4
gene id: 6239:CELE_ZK185.4
uniprot id: Q3V5H7
uniprot id: U4PB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

6239:CELE F41B5.3
gene id: 6239:CELE_F41B5.3
uniprot id: A0A0K3AUW1
uniprot id: O16671
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F07C3.4
gene id: 6239:CELE_F07C3.4
uniprot id: Q5DX34
names: Disruption Phenotype
names: Function
messages: Could be a guanine-nucleotide releasing factor for glo-1 (PubMed:15843430). May play a role in gut granule biogenesis (PubMed:15843430). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).
messages: Worms exhibit lack of intestinal gut granules.

6239:CELE ZK792.6
gene id: 6239:CELE_ZK792.6
uniprot id: P22981
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Expressed in body wall muscles and in the nervous system including ganglion, nerve ring dorsal and ventral nerve cords, motor neurons and sensory tail neurons.
messages: Interacts with soc-2 (PubMed:9674433). Interacts (in GTP-bound form) with plc-1 (via Ras-associating domain 1) (PubMed:9497345).
messages: The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction (PubMed:2257629, PubMed:2123303, PubMed:24929033, PubMed:28135265, PubMed:20230814, PubMed:32053105, PubMed:23103556). May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1 (PubMed:10608844). May induce nuclear condensation (PubMed:23103556).

6239:CELE C06E2.3
gene id: 6239:CELE_C06E2.3
uniprot id: P52484
names: Disruption Phenotype
names: Function
names: Similarity
messages: Acts with E3 ubiquitin-protein ligase trim-21 to catalyze the 'Lys-48'-linked polyubiquitination of ced-1, promoting its proteasomal degradation to maintain appropriate ced-1 levels for apoptotic cell clearance.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: RNAi-mediated knockdown results in increased levels of ced-1.

6239:CELE Y48G8AL.6
gene id: 6239:CELE_Y48G8AL.6
uniprot id: O76512
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm
messages: Phosphorylated probably by smg-1. Smg-3 and smg-4 are required for phosphorylation.
messages: RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity).

6239:CELE T05G5.3
gene id: 6239:CELE_T05G5.3
uniprot id: P34556
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.
messages: Nucleus
messages: Phosphorylated.
messages: Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.
messages: Plays a key role in the control of the eukaryotic cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia (PubMed:20053678).
messages: centrosome

6239:CELE C26E6.2
gene id: 6239:CELE_C26E6.2
uniprot id: Q18225
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Expressed in the embryo (at protein level) (PubMed:18794349). Expressed in most embryonic cells starting at gastrulation and also in head and tail cells during the larval and adult stages (PubMed:18794349).
messages: Knockout causes a nearly wild-type phenotype, but a few young larvae have morphological abnormalities (PubMed:18794349). In a flh-1 mutant background, L1 larvae have severe morphological abnormalities and/or appear necrotic, and 100% die before reaching the L2 larval stage (PubMed:18794349). Embryos exhibit significantly lower expression of lin-14, and overexpression of micro-RNAs, including lin-4, mir-48, mir-241, and mir-34 (PubMed:18794349). In a flh-3 mutant background, embryos exhibit significant overexpression of micro-RNAs, including lin-4, mir-48, mir-230, and mir-65 (PubMed:18794349). RNAi-mediated knockdown has no obvious phenotype, but causes precocious embryonic expression of micro-RNA lin-4, when combined with simultaneous RNAi-mediated knockdown of flh-1 (PubMed:18794349).
messages: Probable transcription factor (PubMed:18794349). May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).

6239:CELE T24A6.9
gene id: 6239:CELE_T24A6.9
uniprot id: A0A131MBQ7
uniprot id: A0A131MCM3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K07D4.8
gene id: 6239:CELE_K07D4.8
uniprot id: O76576
names: Similarity
messages: Belongs to the GILT family.

6239:CELE F56H9.3
gene id: 6239:CELE_F56H9.3
uniprot id: Q20907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE C39H7.1
gene id: 6239:CELE_C39H7.1
uniprot id: Q18553
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C44B7.11
gene id: 6239:CELE_C44B7.11
uniprot id: Q18600
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Endoplasmic reticulum membrane

6239:CELE T10H4.11
gene id: 6239:CELE_T10H4.11
uniprot id: O62377
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T05A6.6
gene id: 6239:CELE_T05A6.6
uniprot id: H2L274
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R11A8.3
gene id: 6239:CELE_R11A8.3
uniprot id: Q21922
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C04D8.1
gene id: 6239:CELE_C04D8.1
uniprot id: P34288
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; this is mediated by interaction with picc-1.
messages: Cell junction
messages: Cytoplasm
messages: Expressed in four-cell stage embryos.
messages: GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60 (PubMed:18583611, PubMed:8288633). Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6 (PubMed:18583611, PubMed:8288633, PubMed:25938815). Required for blastomere polarization (PubMed:25938815).
messages: RNAi-mediated knockdown of isoform a results in mis-localization of par-6 in embryos.
messages: adherens junction

6239:CELE C27H5.2
gene id: 6239:CELE_C27H5.2
uniprot id: H2KZ24
uniprot id: H2KZ25
uniprot id: H2KZ26
uniprot id: Q8IG43
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE CC4.3
gene id: 6239:CELE_CC4.3
uniprot id: G5EEG7
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat SMU1 family.
messages: Component of the spliceosome B complex (By similarity). Homodimer (via LisH domain) (PubMed:27150041). The homodimer interacts (via the N-terminal region including the LisH and CTLH domains) with smu-2, giving rise to a heterotetramer (PubMed:15254247, PubMed:27150041).
messages: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247). In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).
messages: Nucleus
messages: The WD repeats assemble into a seven-bladed WD propeller.
messages: Ubiquitous. Detected in the intestine and germline in adult hermaphrodites.
messages: Ubiquitous. Detected throughout embryonic and larval development and in adult hermaphrodites.

6239:CELE F32H5.1
gene id: 6239:CELE_F32H5.1
uniprot id: P91991
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C18G1.7
gene id: 6239:CELE_C18G1.7
uniprot id: O61918
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C55B7.9
gene id: 6239:CELE_C55B7.9
uniprot id: Q966M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F23C8.6
gene id: 6239:CELE_F23C8.6
uniprot id: Q9TXI3
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE Y41D4A.2
gene id: 6239:CELE_Y41D4A.2
uniprot id: Q95Y22
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T01E8.2
gene id: 6239:CELE_T01E8.2
uniprot id: G5EEQ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed widely and dynamically in the embryo (PubMed:16376329). Expressed in cells of the E blastomere lineage; these go on to form the intestinal primordium (PubMed:15935776). Expressed asymmetrically in the left, but not the right, E4 and E8 cells; however, expression in E8 cells disappears late in the E8 stage, then is observed on the right side of the E16 primordium (PubMed:15935776). These expression patterns are dependent on Notch signaling (PubMed:15935776). Also expressed in a subset of the AB anterior blastomere lineage, including the descendants of the ABa cells, such as ABarpap, which are precursors of the right side of the head (PubMed:15935776). Expressed in ABplp(a/p), ABalp(a/p), ABprp(a/p), ABara(a/p), and weakly in the ABarp(a/p) blastomeres at approximately 100 minutes after fertilization (PubMed:16376329). Expressed in a Notch-independent manner in the EMS lineage, in all EMS granddaughters beginning at the 24-cell stage (PubMed:15935776).
messages: Interacts with unc-37.
messages: Nucleus
messages: Probable transcription factor (PubMed:15935776, PubMed:16376329, PubMed:11311160). Binds 5'-TGCCACGTGTCCA-3' in vitro, probably via the E-box motif 5'-CA[TC][AG]TG-3' (PubMed:15935776). Acts in embryonic development in a Notch-dependent manner, perhaps as a direct target of transcriptional regulator lag-1 in the Notch signaling pathway (PubMed:15935776, PubMed:16376329). Also acts in embryonic development in a Notch-independent manner (PubMed:15935776). Plays a role in both Notch-dependent and -independent pathways in the execution of neuronal lineage decisions in the embryo (PubMed:16376329). Also involved in regulating cell fate leading to formation of neuronal structures known as postdeirids (PubMed:11311160). Involved in the pattern of cell fusion with a large syncytium known as hyp-7, during larval development, in hermaphrodites (PubMed:11311160). Plays a role in regulating the activity of homeobox protein mab-5 in Pn.p cells (PubMed:11311160).
messages: RNAi-mediated knockdown causes the formation of misshapen heads as well as ectopic V6 postdeirids.

6239:CELE C34D10.2
gene id: 6239:CELE_C34D10.2
uniprot id: L8E6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

6239:CELE W09B6.2
gene id: 6239:CELE_W09B6.2
uniprot id: A0A0S4XR63
uniprot id: A0A0S4XRA5
uniprot id: A0A0S4XRY0
uniprot id: Q9GZI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

6239:CELE F26C11.1
gene id: 6239:CELE_F26C11.1
uniprot id: Q09549
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE C44H4.6
gene id: 6239:CELE_C44H4.6
uniprot id: Q93372
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE Y53C12A.1
gene id: 6239:CELE_Y53C12A.1
uniprot id: O18209
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation (PubMed:16338136, PubMed:16421191, PubMed:16466390). Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis (PubMed:11702779, PubMed:12397109, PubMed:27104746). Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown (PubMed:16421191).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Cytoplasm
messages: Expressed during both germline and early embryonic development. In larvae, it is expressed in the distal region, germline, and in some neurons and hypodermal cells. Not expressed in distal region of the adult.
messages: Golgi apparatus membrane
messages: Worms exhibit oocytes that mature prematurely (also known as the Emo phenotype) and chromosomes that appear condensed (PubMed:16421191). Subcellular defects include irregular perinuclear foci in oocytes (PubMed:16421191). RNAi-mediated knockdown results in an accumulation of damaged, compressed, polyploid oocytes in the uterus (PubMed:11702779). RNAi-mediated knockdown in a double oma-1 and oma-2 knockout background allows for the progression of meiosis beyond the prophase stage and oocyte maturation, but these oocytes cannot be fertilized (PubMed:11702779). RNAi-mediated knockdown in a cdc-25.2 mutant background suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746).

6239:CELE K11H3.6
gene id: 6239:CELE_K11H3.6
uniprot id: Q7YWY8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

6239:KEF34 p05
gene id: 6239:KEF34_p05
uniprot id: G5EF66
uniprot id: P24892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

6239:CELE Y39D8A.1
gene id: 6239:CELE_Y39D8A.1
uniprot id: H2KYC1
uniprot id: H2KYC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE F35H8.7
gene id: 6239:CELE_F35H8.7
uniprot id: Q20085
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Expression is first seen in the 12-13-cell embryo and is last observed in the 16-cell embryo before division.
messages: In the 12-13-cell embryo, expressed in the E blastomere. In the 16-cell embryo, expressed in the eight AB cells.
messages: Nucleus

6239:CELE W01C8.6
gene id: 6239:CELE_W01C8.6
uniprot id: Q9GNP0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58G6.9
gene id: 6239:CELE_F58G6.9
uniprot id: A5JYS6
uniprot id: C6KRJ4
uniprot id: Q5CZ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Late endosome membrane
messages: Membrane

6239:CELE Y75B8A.16
gene id: 6239:CELE_Y75B8A.16
uniprot id: Q9U1S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

6239:CELE H06I04.4
gene id: 6239:CELE_H06I04.4
uniprot id: P37165
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

6239:CELE R12H7.1
gene id: 6239:CELE_R12H7.1
uniprot id: A0A1C3NSM1
uniprot id: O01393
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed in PLM neurons (at protein level). Expressed in the nerve ring (PubMed:33238150).
messages: Heterooligomer of unc-7 and unc-9. Interacts with F-actin (PubMed:33238150).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of gap junctions (PubMed:27015090, PubMed:33238150). Plays a role in maintaining gap junction activity to promote locomotion (PubMed:33238150).
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE T19H12.4
gene id: 6239:CELE_T19H12.4
uniprot id: O01609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y119D3B.16
gene id: 6239:CELE_Y119D3B.16
uniprot id: Q95Y71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL45 family.
messages: Mitochondrion

6239:CELE C44E4.1
gene id: 6239:CELE_C44E4.1
uniprot id: A0A0S4XR36
uniprot id: O01808
names: Similarity
messages: Belongs to the UBR4 family.

6239:CELE T23D8.4
gene id: 6239:CELE_T23D8.4
uniprot id: O02328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE R13A5.6
gene id: 6239:CELE_R13A5.6
uniprot id: Q95Y93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE ZK353.1
gene id: 6239:CELE_ZK353.1
uniprot id: P34624
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal localization of synaptic vesicle components and active zone proteins in the cell body and in the dentrite of DA9 motor neuron (PubMed:20510931). In L4 mutants, incomplete elimination of ventral rab-3-positive synaptic vesicles and small reduction in the formation of dorsal rab-3-positive synaptic vesicles in DD motor neurons, although formation of ventral synapses at the L1 stage is normal (PubMed:21609829). No other phenotype except a slightly smaller progeny size (PubMed:20510931).
messages: Belongs to the cyclin family.
messages: Cytoplasm
messages: In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons (PubMed:20510931). Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures (PubMed:21609829). May activate cdk-5 (PubMed:20510931).
messages: Interacts with pct-1; the interaction is required to activate pct-1.
messages: axon
messages: dendrite

6239:CELE R13F6.3
gene id: 6239:CELE_R13F6.3
uniprot id: P46564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srv family.
messages: Membrane

6239:CELE Y46G5A.10
gene id: 6239:CELE_Y46G5A.10
uniprot id: Q9U2D6
names: Developmental Stage
names: Disruption Phenotype
names: Subunit
names: Tissue Specificity
messages: Expressed from the gastrula stage throughout adulthood.
messages: Expressed in intestine.
messages: Interacts with tax-6.
messages: RNAi-mediated knockdown results in no obvious phenotype.

6239:CELE R151.3
gene id: 6239:CELE_R151.3
uniprot id: P47991
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL6 family.
messages: Component of the large ribosomal subunit (By similarity). May bind IPO9 with low affinity (By similarity).
messages: Component of the large ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

6239:CELE K11E4.5
gene id: 6239:CELE_K11E4.5
uniprot id: Q9GTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R04F11.4
gene id: 6239:CELE_R04F11.4
uniprot id: B0M0M8
uniprot id: K8ESB6
uniprot id: K8F7Q8
uniprot id: Q21729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C01G8.9
gene id: 6239:CELE_C01G8.9
uniprot id: X5M5M2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y49A10A.1
gene id: 6239:CELE_Y49A10A.1
uniprot id: Q9XWW8
names: Subcellular Location Annotation
messages: cilium axoneme

6239:CELE F27D9.2
gene id: 6239:CELE_F27D9.2
uniprot id: Q19845
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T07E3.5
gene id: 6239:CELE_T07E3.5
uniprot id: G5EG86
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in the germline, with highest expression in cells undergoing oogenesis.
messages: Interacts (via N-terminus) with rad-51; regulates rad-51 recruitment to sites of DNA double strand breaks (PubMed:15798199, PubMed:17483448).
messages: Mutant animals are egg-laying defective and exhibit a reduced brood size and high embryonic lethality (PubMed:15798199, PubMed:18779660). Impaired formation of rad-51 foci and accumulation of rpa-1 foci in the meiotic region of the germline in mutants either untreated or treated with ionizing radiation (IR), indicating impaired DNA double strand break repair by homologous recombination (PubMed:15798199, PubMed:18779660). Decompaction of chromatin, chromosome aggregation and aberrant number of bivalent chromosomes during meiosis (PubMed:15798199, PubMed:18779660). In a telomerase trt-1 mutant background, RNAi-mediated knockdown leads to telomere shortening in early generations, to telomere elongation in late generations and to a delay in generational replicative senescence (PubMed:27761361).
messages: Nucleus
messages: Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity (PubMed:15798199, PubMed:16843491). Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51 (PubMed:15798199, PubMed:16843491, PubMed:17483448, PubMed:18779660). Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA (PubMed:16843491). Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homologous recombination (HR) and non-homologous end joining (NHEJ) pathways are compromised (PubMed:15798199, PubMed:16843491). Binds selectively to single-stranded (ssDNA) via its C-terminus (PubMed:15798199). Involved in telomere maintenance and replicative senescence (PubMed:27761361).
messages: The BRCA2 repeat-like region is required for rad-51 binding.

6239:CELE R160.7
gene id: 6239:CELE_R160.7
uniprot id: Q9TZD0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the lst-2 family.
messages: Causes ectopic vulval induction.
messages: Expressed in vulval precursor cells (VPCs).
messages: Highly expressed in all 6 vulval precursor cells (VPCs). At the time of inductive signaling, expression forms a gradient in response to inductive signal: expression is low in P6.p, intermediate in P5.p and P7.p and undiminished in P3.p, P4.p, and P8.p. Later, expression becomes strong again in P5.p and P7.p.
messages: Negative regulator of epidermal growth factor receptor (EGFR) signaling.

6239:CELE F13E6.6
gene id: 6239:CELE_F13E6.6
uniprot id: G5EFE1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

6239:CELE Y113G7B.24
gene id: 6239:CELE_Y113G7B.24
uniprot id: Q9U2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

6239:CELE C16C10.2
gene id: 6239:CELE_C16C10.2
uniprot id: Q09462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

6239:CELE C36B1.5
gene id: 6239:CELE_C36B1.5
uniprot id: Q93339
names: Subcellular Location Annotation
messages: Nucleus speckle

6239:CELE M04G12.3
gene id: 6239:CELE_M04G12.3
uniprot id: P92006
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE B0491.8
gene id: 6239:CELE_B0491.8
uniprot id: G5EEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

6239:CELE F15B9.9
gene id: 6239:CELE_F15B9.9
uniprot id: Q7YXD2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE C36A4.8
gene id: 6239:CELE_C36A4.8
uniprot id: B6VQ60
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Animals are viable (PubMed:18219312, PubMed:19646877). However, there is defective double strand break repair (PubMed:18219312, PubMed:19646877, PubMed:26903030). During the early stages of meiosis, this is characterized by impaired homologous recombination in germ cells with increased apoptosis and increased numbers of rad-51-positive foci (PubMed:18219312, PubMed:19646877). Increased sensitivity to UV and IR irradiation and topoisomerase inhibitor camptothecin compared to wild-type (PubMed:24424777, PubMed:26903030). Following either IR irradiation or camptothecin treatment, there is reduced egg hatching (PubMed:26903030). Furthermore, there are also DNA damage repair defects following ionizing radiation and UV irradiation characterized by reduced ubiquitination at DNA damage sites and reduced rad-51-positive foci, respectively (PubMed:16628214, PubMed:24424777, PubMed:26903030). High levels of embryonic lethality and abolished brd-1 expression following DNA damage induced by ionising radiation (PubMed:30383754). Double knockout with brd-1 impairs rad-51 localization to DNA damage sites following DNA damage induced by ionising radiation (PubMed:30383754). RNAi-mediated knockdown results in high X chromosome non-disjunction leading to a high incidence of males (him) phenotype (PubMed:14711411). RNAi-mediated knockdown in addition to gamma-irradiation at the L4 stage of larval development, results in reduced progeny, increased cep-1/p53-dependent germ cell death, chromosome fragmentation and DNA repair defects (PubMed:14711411).
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase activity of CeBCD complexes occurs at DNA damage sites. Following DNA damage, E3 ubiquitin-protein ligase activity is reduced by caffeine treatment (inhibitor of ATM and ATK kinase activity).
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair (PubMed:16628214). Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example (PubMed:14711411, PubMed:16628214, PubMed:24424777, PubMed:26903030, PubMed:30383754). Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells (PubMed:18219312, PubMed:19646877, PubMed:24424777, PubMed:26903030). In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability (PubMed:14711411, PubMed:18219312, PubMed:24424777). Required for normal cell cycle progression (PubMed:20207739). Along with brap-2 modulates the expression of cell cycle arrest protein cki-1 in response to increased levels of reactive oxygen species (PubMed:20207739). Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity (PubMed:14711411). When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase (PubMed:16628214). Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites (PubMed:16628214). To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:14711411).
messages: Heterodimer (via RING-type zinc finger) with brd-1 to form the core CeBCD complex (PubMed:14711411, PubMed:16628214). Brc-1-brd-1 heterodimer-containing CeBCD complexes bound to chromatin are activated as an E3-ubiquitin ligase in response to DNA damage (PubMed:16628214). The heterodimer interacts with the recombinase rad-51 following ionizing irradiation; the interaction is direct (PubMed:16628214). The heterodimer interacts the E2-ubiquitin-conjugating enzyme let-70 following ionizing irradiation (PubMed:16628214). The heterodimer interacts with the pro-crossover proteins msh-5 and syp-3 (PubMed:30383754).
messages: Nucleus
messages: Phosphorylation of CeBCD complexes is required for E3 ubiquitin-protein ligase activity.

6239:CELE C34D4.9
gene id: 6239:CELE_C34D4.9
uniprot id: Q18439
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y104H12A.1
gene id: 6239:CELE_Y104H12A.1
uniprot id: Q3V5L2
uniprot id: U4PEU7
uniprot id: U4PMI0
uniprot id: U4PRQ4
uniprot id: U4PRT9
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C39H7.6
gene id: 6239:CELE_C39H7.6
uniprot id: Q18552
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F59E12.4
gene id: 6239:CELE_F59E12.4
uniprot id: H2KYU6
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPL4 family.
messages: Cytoplasm
messages: Forms a complex composed of ubxn-3, ufd-1, npl-4.1 and cdc-48.1; within the complex, interacts with ufd-1 and ubxn-3 (PubMed:20977550). Interacts with ufd-1 (PubMed:16647269). Interacts with elc-1/elongin C; the interaction may mediate the interaction between the npl-4-ufd-1-cdc-48 complex and the E3 ubiquitin ligase cul-2 complex (PubMed:19773360).
messages: In association with ufd-1 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338). During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).
messages: Nucleus
messages: Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 causes embryonic lethality (PubMed:16647269, PubMed:26842564). In embryos, DNA replication is partially impaired causing a delay in S phase progression in P0, AB and P1 cells; simultaneous RNAi-mediated knockdown of DNA replication checkpoint kinases chk-1 or atl-1 suppresses the delay in S phase (PubMed:18728180, PubMed:26842564). During S phase, prevents DNA replication licensing factor cdt-1 down-regulation and causes cdt-1 accumulation on mitotic chromosomes (PubMed:21981920). Impairs dissociation from the chromatin of components of the DNA replication machinery, including cdc-45, GINS complex component sld-5 and CMG helicase component mcm-3, resulting in their persistent association with chromatin throughout embryonic mitosis (PubMed:21981920, PubMed:26842564, PubMed:28368371). Abnormal ubxn-3 localization into punctate structures in the nucleus (PubMed:26842564). Reduces ufd-1 expression in embryos (PubMed:21981920, PubMed:26842564). Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 in adults causes a proliferation arrest of mitotic germline cells in the gonad with formation of rad-51 foci on chromatin (PubMed:18728180). Induces the unfolded protein response and increases sensitivity to tunicamycin-induced ER stress (PubMed:16647269). Causes accumulation of misfolded protein cpl-1 in the ER (PubMed:22768338).
messages: There is another gene, npl-4.2, which has a 99% identical sequence making it difficult to identify the specific function for each protein.

6239:CELE F18C5.6
gene id: 6239:CELE_F18C5.6
uniprot id: Q19550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE Y45F3A.3
gene id: 6239:CELE_Y45F3A.3
uniprot id: Q9XWZ2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: By heat. Two-fold induction at 25 degrees Celsius compared with 15 degrees Celsius.
messages: Homotetramer; dimer of dimers.
messages: Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.
messages: Temperature-sensitive mutants in which embryos develop to adulthood at 15 and 20 degrees Celsius, but have a poor survival incidence at 25 degrees Celsius. Mutants have increased membrane fluidity and abnormal compositions of fatty acid species.

6239:CELE C05E4.1
gene id: 6239:CELE_C05E4.1
uniprot id: O17365
names: Similarity
messages: Belongs to the serpin family.

6239:CELE C25E10.9
gene id: 6239:CELE_C25E10.9
uniprot id: Q18158
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In male, expressed in the vas deferens cuboidal cells and, in posterior body wall and male-specific diagonal muscles (PubMed:30470702). In hermaphrodites, expressed in posterior body wall muscles and spermatheca (PubMed:30470702).
messages: In males, expression begins at late larval stage and continues in adults.
messages: Secreted
messages: Serine protease inhibitor (Probable) (PubMed:22125495). Probably by inhibiting serine protease tyr-5 in males, prevents the maturation of spermatids into mature motile spermatozoa until their transfer into a hermaphrodite (PubMed:16461278, PubMed:22125495, PubMed:30470702). Also required for efficient sperm transfer and thus for male fertility (PubMed:16461278).
messages: secretory vesicle lumen

6239:CELE F36H2.1
gene id: 6239:CELE_F36H2.1
uniprot id: G5EBH1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Cell membrane
messages: Plays a role in regulating membrane trafficking of cargo proteins during embryogenesis (PubMed:22100064, PubMed:30213940). Regulates snx-3 retromer-mediated endosomal sorting of mig-14, a transporter of Wnt egl-20 morphogen (PubMed:30213940). Together with mon-2 and pad-1, may participate in the formation of endosomal carriers that direct mig-14 trafficking back to Golgi, away from lysosomal degradation. Required for Wnt egl-20 gradient formation along the anteroposterior body axis and migration of QL neuroblast descendants toward the posterior part (PubMed:30213940). Maintains phosphatidylethanolamine (PE) asymmetry at the cell membrane and prevents the budding of ectosome vesicles that affect intercellular communication and morphogenesis (PubMed:22100064).
messages: Produced by alternative promoter usage and alternative splicing.
messages: Produced by alternative splicing.

6239:CELE M01D7.4
gene id: 6239:CELE_M01D7.4
uniprot id: O01969
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

6239:CELE C54D10.2
gene id: 6239:CELE_C54D10.2
uniprot id: Q18832
names: Similarity
messages: Belongs to the FAX family.

6239:CELE K08H2.6
gene id: 6239:CELE_K08H2.6
uniprot id: G5EET5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in embryos at about the 50 cell stage (PubMed:16905130). Expressed in most, but not all cells of larvae and adults, especially in neuronal and hypodermal cells (PubMed:16905130).
messages: Interacts with histone demethylase spr-5 (PubMed:26476455). Interacts with chromobox protein homolog hpl-2 (PubMed:26476455, PubMed:22083954). Interacts with histone H3 tails methylated at 'Lys-9' (H3K9me3) and 'Lys-23'(H3K23me2) (PubMed:26476455). Interacts with histone H1 variant his-24 (when monomethylated at 'Lys-14'); the interaction is direct (PubMed:22083954). May interact with the REST corepressor rcor-1, histone deacetylase hda-1, and the histone demethylase lsd-1 (PubMed:26476455).
messages: Nucleus
messages: RNAi-mediated knockdown in a hpl-2 mutant background causes larval arrest.
messages: Seems to be involved in transcriptional silencing in heterochromatin-like complexes (By similarity). Involved in epigenetic repression (By similarity). Probably does not act as global transcriptional repressor (PubMed:23028351). Plays a role in linking epigenetic regulation with the innate immune response (PubMed:22083954). Acting in concert with chromobox protein homolog hpl-2 and histone H1 protein his-24, involved in reproduction, somatic gonad development, male tail development and vulval cell fate decisions; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5 (PubMed:23028351, PubMed:16905130). Role in growth and somatic gonad development is antagonized by histone-lysine N-methyltransferase set-2/SET1 (PubMed:17967446). Required for larval development, acting redundantly with hpl-2 (PubMed:26476455, PubMed:16905130). Plays a role in the formation of the vulva and in fertility, acting together with a CoREST-like complex, and hpl-2 (PubMed:26476455, PubMed:16905130).

6239:CELE R04B5.5
gene id: 6239:CELE_R04B5.5
uniprot id: Q21702
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE F07C4.4
gene id: 6239:CELE_F07C4.4
uniprot id: P91210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE K08F8.4
gene id: 6239:CELE_K08F8.4
uniprot id: P90925
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine (PubMed:18460651, PubMed:10928216). Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan (PubMed:10928216). Plays a role in the biosynthesis of a melanin-like cuticle pigment (PubMed:18460651).
messages: Cytoplasm
messages: Expressed during all larval stages and in adult animals (at protein level).
messages: Expressed in the seam cells of the lateral hypodermis, in the ventral hypodermis and in the hyp7 hypodermal syncytium, in hypodermal cells in the tail and in body wall muscle cells (at protein level).
messages: Homotetramer.
messages: Inhibited by tetrahydrobiopterin. Unlike its mammalian orthologs, pah-1 does not exhibit allosteric binding behavior for phenylalanine.
messages: Reduced L-phenylalanine hydroxylation. Lack of a yellow-orange pheomelanine-like pigment in the cuticle. Higher cuticle resistance to physical or chemical disintegration factors or oxidizing environments. Increase in superoxide dismutase activity. Increased life span. In a bli-3(e767) mutant background, growth arrest in early larval development, severe cuticle abnormalities with large blisters and increased superoxide dismutase activity. RNAi-mediated knockdown together with fah-1 RNAi partially rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).

6239:CELE C26C6.2
gene id: 6239:CELE_C26C6.2
uniprot id: P51875
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Expressed in the ASER neuron and the intestine.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts (in GDP-bound form) with gpr-1; gpr-1 forms a complex with gpr-2 and lin-5 (PubMed:12730122). Interacts (in GDP-bound form) with gpb-1 (PubMed:12730122). Interacts (in GDP-bound form) with gbas-1 (via GBA motif); the interaction leads to activation of goa-1 (PubMed:26659249).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle (PubMed:14534135). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122). Involved in chemosensory responses to attractive and repellent odors detected by AWC and AWB sensory neurons, respectively (PubMed:23954825). In ASER neurons, acts downstream of glr-3 to regulate cold avoidance behavior via calcium signaling, and it may also play a role in sensing cold in the intestine (PubMed:31474366). Negatively regulates axon regeneration after injury downstream of the inhibitory compound arachidonoyl ethanolamide (AEA) by antagonizing the activation of the JNK pathway (mlk-1/mek-1/kgb-1) (PubMed:23072806). In neurons, may negatively regulate diacylglycerol (DAG) production mediated by egl-30 signaling cascade and thereby negatively regulates acetylcholine release (PubMed:22897658). Couples to the muscarinic acetylcholine receptor gar-2 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030). Involved in egg-laying and in regulating dopamine-mediated locomotion (PubMed:8548815, PubMed:15378064). Most likely couples to the dopamine receptors dop-2 and dop-3 to positively regulate the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons in the pr…
messages: Prolonged exposure to attractive odorant benzaldehyde results in a loss of adaptive response characterized by a decrease in odor seeking behavior and in a loss of egl-4 nuclear translocation. Loss of chemotaxis response to the repellent odor 2-nonanone (PubMed:23954825). Increased egg laying; eggs are prematurely laid at one-cell to 8-cell stage (PubMed:8548815). Increased locomotion (PubMed:8548815). Increases diacylglycerol (DAG) levels along axons. Increases paralysis following treatment with acetylcholinesterase inhibitor aldicarb which is partially reduced in a drn-1 mutant background (PubMed:22897658). In a mutant background which expresses gar-2 in all cholinergic motor neurons, eliminates the resistance to Aldicarb that is characteristic of the gar-2 single mutant (PubMed:18614679). Simultaneous RNAi-mediated knockdown of both goa-1 and gpa-16 causes, in the one-cell embryo, a lack of nuclear rocking movements from prophase to metaphase and symmetric spindle elongation without transversal oscillations of the poles during anaphase (PubMed:14534135). At the 2-cell stage embryo, nuclei are mispositioned and fail to exhibit nuclear rotation (PubMed:14534135). In addition, causes a loss of gpr-1/2 cortical localization in 2-cell and 4-cell stage embryos (PubMed:14534135).

6239:CELE VF36H2L.1
gene id: 6239:CELE_VF36H2L.1
uniprot id: O45876
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.
messages: Membrane

6239:CELE F47G6.4
gene id: 6239:CELE_F47G6.4
uniprot id: Q9TZI9
uniprot id: W6RY57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: myofibril

6239:CELE F14H8.1
gene id: 6239:CELE_F14H8.1
uniprot id: B2D6P3
uniprot id: Q93485
names: Similarity
messages: Belongs to the OSBP family.

6239:CELE Y17G9B.5
gene id: 6239:CELE_Y17G9B.5
uniprot id: Q9N580
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

6239:CELE C13D9.9
gene id: 6239:CELE_C13D9.9
uniprot id: O16243
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C14C10.7
gene id: 6239:CELE_C14C10.7
uniprot id: Q95QW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C36C5.2
gene id: 6239:CELE_C36C5.2
uniprot id: O16412
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C07G3.10
gene id: 6239:CELE_C07G3.10
uniprot id: Q965N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE C53B4.5
gene id: 6239:CELE_C53B4.5
uniprot id: Q18799
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F36D3.4
gene id: 6239:CELE_F36D3.4
uniprot id: O45462
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE W02F12.5
gene id: 6239:CELE_W02F12.5
uniprot id: O45148
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

6239:CELE C40H1.5
gene id: 6239:CELE_C40H1.5
uniprot id: Q03575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y38C1AA.9
gene id: 6239:CELE_Y38C1AA.9
uniprot id: Q9N432
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W10D5.1
gene id: 6239:CELE_W10D5.1
uniprot id: Q9U325
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEF2 family.
messages: Down-regulated by microRNA mir-1 (PubMed:18510933). Up-regulated in many head neurons during prolonged starvation (PubMed:27487365).
messages: Expressed broadly throughout most of development.
messages: Interacts with histone deacetylase hda-4 isoform b.
messages: Nucleus
messages: Transcription regulator (PubMed:17170704, PubMed:27487365). Binds specifically to the MEF2 element, 5'-[TC]TA[AT][AT][AT][AT]TA[AG]-3' in the regulatory elements of target genes, such as chemoreceptors str-1 and srh-234 (PubMed:10882527, PubMed:17170704, PubMed:27487365). Involved in transduction of sensory signals, together with egl-4, kin-29 and hda-4; binding to histone deacetylase hda-4 enables negative modulation of chemoreceptor gene expression in chemosensory neurons (PubMed:17170704, PubMed:18832350). In response to starvation, negatively modulates expression of chemoreceptor srh-234 in ADL sensory neurons, acting in concert with basic helix-loop-helix (bHLH) transcription factors (PubMed:27487365). Plays a role in regulating muscle sensitivity to acetylcholine (ACh) and the magnitude of presynaptic ACh release via a retrograde signal, perhaps by indirectly decreasing Ras-related protein Rab-3 activity (PubMed:18510933).

6239:CELE ZK6.4
gene id: 6239:CELE_ZK6.4
uniprot id: O61869
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T21E3.1
gene id: 6239:CELE_T21E3.1
uniprot id: O01767
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Expressed in developing oocytes (at protein level).
messages: Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition (PubMed:19879842, PubMed:19879147). Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization (PubMed:19879147). Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I (PubMed:19879842). Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization (PubMed:19879147).
messages: Part of a complex, consisting of pseudophosphatases egg-3, egg-4, egg-5 and kinase mbk-2; this complex is required for the oocyte-to-zygote transition (PubMed:19879842). Interacts (via tyrosine-protein phosphatase domain) with kinase mbk-2 (via 'Tyr-619' and 'Tyr-621'); mbk-2 tyrosine phosphorylation enhances the interaction (PubMed:19879842). The interaction inhibits mbk-2 kinase activity and is required for mbk-2 oocyte cortex localization (PubMed:19879842, PubMed:19879147). Interacts with egg-3 (PubMed:19879147).
messages: Severe reduction in the number of hatched larvae (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 results in no viable progeny and causes endomitosis in the uterus, generation of polyspermic embryos and defects in meiosis completion, polar body formation and eggshell chitin layer formation (PubMed:19879147). In addition, posterior formation of F-actin cap at the cortex oocyte and its polarized dispersal after fertilization are impaired (PubMed:19879147). Prevents mbk-2 localization to the unfertilized oocyte cortex without affecting egg-3 cortical localization (PubMed:19879842, PubMed:19879147). Prevents mbk-2, egg-3 and chs-1 re-localization to cytoplasmic foci at meiosis anaphase I (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 and mel-26 causes premature phosphorylation of mei-1, a mbk-1 substrate, during oocyte maturation (PubMed:19879842).
messages: The active site Cys-600 is replaced by a Asp residue suggesting that egg-4 may lack catalytic activity. Despite the lack of catalytic activity, egg-4 may retain the capacity to bind to phosphorylated substrates. Does not dephosphorylate mbk-2 (PubMed:19879842).
messages: cell cortex

6239:CELE C49F5.2
gene id: 6239:CELE_C49F5.2
uniprot id: O17679
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Broadly expressed in the nervous system, including head, body and tail neurons.
messages: Chromosome
messages: Expression increases with age.
messages: Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2 (PubMed:32103178). Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178). Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178). Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
messages: Interacts with baz-2.
messages: Nucleus
messages: RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

6239:CELE C08F11.12
gene id: 6239:CELE_C08F11.12
uniprot id: Q9U3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE ZK643.3
gene id: 6239:CELE_ZK643.3
uniprot id: A7LPE2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F55A8.1
gene id: 6239:CELE_F55A8.1
uniprot id: G5EGF4
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all seam cells and in many other cells in the head and tail regions at embryonic ~1.5-fold and ~threefold stages (at protein level) (PubMed:11532911). Expressed in the vulval precursor cell (VPC) lineages and in VC neurons, starting at about the mid-L2 larval stage (PubMed:12399309). Expressed asymmetrically in seam cell daughters during larval life; expression is highest in the posterior daughter and lower in the anterior daughter cell after the L1 cell division (PubMed:23633508). However, in early stage L2, expression is symmetric in the seam-fated daughters of the first division (PubMed:23633508). Expression in the head and trunk increases with age between days 2 and 12 (PubMed:18662544).
messages: Expressed in differentiated seam cells (PubMed:23633508). Expressed in the head and trunk (PubMed:18662544).
messages: Not only are egl-18/elt-5 and elt-6 moderately similar (46% identical) paralogous genes, but they may be transcribed both monocistronically and dicistronically in a tissue-dependent manner, so complicating interpretation of knockdown and expression experiments.
messages: Nucleus
messages: Probable transcription factor (PubMed:11532911, PubMed:24885717). Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with elt-6 (PubMed:11532911, PubMed:14975731, PubMed:12399309, PubMed:24885717). Perhaps acting together with elt-6, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification (PubMed:24885717). Together with elt-6, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate (PubMed:23633508). Required in seam cells, acting redundantly with elt-6, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state (PubMed:11532911, PubMed:23633508). Plays a role in longevity (PubMed:18662544). May form a transcriptional circuit with GATA factors elt-3 and elt-6 (PubMed:18662544).
messages: RNAi-mediated knockdown in hermaphrodites causes their progeny to arrest late in embryogenesis (pretzel stage) or as early L1 larvae (PubMed:11532911). Arrested L1 larvae are invariably uncoordinated, lumpy and somewhat short and stout (PubMed:11532911). Also, the entire larval buccal capsule, the cuticular structure of the mouth, invariably fails to attach to the anterior-most region of the head (PubMed:11532911). RNAi-mediated knockdown at day 5 of adulthood (earlier RNAi treatment causes worms to become sick) causes extended longevity and also increases expression of elt-3 in the trunk hypodermis; longevity effect is suppressed in an elt-3 mutant background (PubMed:18662544). Knockdown at day 5 of adulthood slightly increases resistance to heat shock and to paraquat treatment (PubMed:18662544). RNAi-mediated knockdown at the L1 stage reduces the average number of seam cells per side; reduced further in an elt-6 mutant background (PubMed:11532911). RNAi-mediated knockdown at the L3 stage in an elt-6 mutant background reduces expression of lin-39.

6239:CELE Y59A8B.22
gene id: 6239:CELE_Y59A8B.22
uniprot id: D9PTP5
uniprot id: D9PTP6
uniprot id: D9PTP7
names: Similarity
messages: Belongs to the sorting nexin family.

6239:CELE H38K22.1
gene id: 6239:CELE_H38K22.1
uniprot id: G5EC05
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y39E4B.4
gene id: 6239:CELE_Y39E4B.4
uniprot id: Q9U2K6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05B4.11
gene id: 6239:CELE_T05B4.11
uniprot id: O16420
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C44C3.2
gene id: 6239:CELE_C44C3.2
uniprot id: P91159
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0310.5
gene id: 6239:CELE_B0310.5
uniprot id: Q10941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE R08F11.5
gene id: 6239:CELE_R08F11.5
uniprot id: O01888
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F11A1.3
gene id: 6239:CELE_F11A1.3
uniprot id: G5EFF5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed throughout muscles of the pharynx (PubMed:11072073). Expressed in epidermal seam cells, the vulva, head neurons, mature spermatheca, uterus and intestine (PubMed:10859169, PubMed:23990780).
messages: Interacts with din-1 isoform d.
messages: Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:9477318, PubMed:10859169, PubMed:15314028, PubMed:15489294, PubMed:15383841, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518). Activity is modulated by binding of steroid hormone ligands that include dafachronic acids (PubMed:16529801). Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues (PubMed:9477318, PubMed:10859169, PubMed:15489294, PubMed:15383841, PubMed:16626392, PubMed:19828440, PubMed:21814518). Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1 (PubMed:19828440). Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153). Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs (PubMed:23990780). Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth (PubMed:25774872). May be involved in thermotolerance (PubMed:24957743).
messages: Nucleus
messages: Produced by alternative initiation at Met-487 of isoform a.
messages: Produced by alternative initiation at Met-60 of isoform a.
messages: Produced by alternative splicing.
messages: Reduced lifespan associated with accelerated aging and increased tissue deterioration (PubMed:16626392). Defective dauer formation (PubMed:9477318, PubMed:10859169). In the absence of cholesterol, arrest with abnormal cuticle formation (PubMed:15383841). Increased resistance to P.aeruginosa infection possibly due to elevated expression of antimicrobial genes (PubMed:23990780). Prevents increase in the number of muscle arm extension in a daf-2 (e1375) background (PubMed:18436204). RNAi-mediated knockdown results in reduced lifespan, but increased resistance to bacterial infection (PubMed:23990780).
messages: Widely expressed from embryo through to adult stages; peak expression levels seem to occur during larval stage L2.

6239:CELE Y53F4B.42
gene id: 6239:CELE_Y53F4B.42
uniprot id: Q2MDF2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

6239:CELE F10G7.3
gene id: 6239:CELE_F10G7.3
uniprot id: Q19326
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

6239:CELE K12H6.3
gene id: 6239:CELE_K12H6.3
uniprot id: G5EEL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

6239:CELE K03B8.1
gene id: 6239:CELE_K03B8.1
uniprot id: Q21180
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C05B5.6
gene id: 6239:CELE_C05B5.6
uniprot id: P34294
names: Similarity
messages: Belongs to the FTH family.

6239:CELE Y105C5B.15
gene id: 6239:CELE_Y105C5B.15
uniprot id: A0A078BQP7
uniprot id: Q9U309
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

6239:CELE M106.4
gene id: 6239:CELE_M106.4
uniprot id: Q09580
names: Subunit
messages: Homodimer.

6239:CELE C05G6.1
gene id: 6239:CELE_C05G6.1
uniprot id: Q65CM0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in the intestine.
messages: Ligand-activated transcription factor (By similarity). Involved in modulating serotonin-mediated induction of adipose triglyceride lipase atgl-1, thereby regulating body fat (PubMed:24120942).
messages: Nucleus
messages: RNAi-mediated knockdown abrogates the increase in adipose triglyceride lipase atgl-1 expression seen in serotonin-treated animals.

6239:CELE F55C7.7
gene id: 6239:CELE_F55C7.7
uniprot id: O61528
uniprot id: Q7JNG6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

6239:CELE R05D3.11
gene id: 6239:CELE_R05D3.11
uniprot id: P34544
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Cytoplasm
messages: Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3 (PubMed:20107519, PubMed:22939621). This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9' (PubMed:22939621). Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development (PubMed:17634190). Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish between the partnerless male X chromosome and asynapsed chromosomes thereby shielding the lone X from inappropriate activation of an apoptotic program (PubMed:21909284). Operates redundantly with set-25 to position chromatin at the nuclear periphery (PubMed:22939621). Required for small-RNA-induced H3K9 methylation (PubMed:26365259). Together with set-25, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9 (PubMed:27668659). Together with spr-5, required for transgenerational fertility (PubMed:24685137).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Induced vulval precursor cells in the absence of lin-15A (PubMed:15990876). Multi-vulval phenotype is apparent when grown at 24.5 degrees Celsius in the absence of lin-61 and when grown at 20 degrees Celsius in the absence of hpl-2 or met-1 (PubMed:17634190, PubMed:21437264). Reduced lamin interaction of chromosome arms in the absence of set-25 (PubMed:22939621). Increased apoptosis and increased occurrence of the recombination checkpoint XO germ lines (PubMed:21909284). High incidence of endomitotic oocytes (PubMed:20107519). In spr-5 null mutants, accelerates the progressive sterility over generations, which is seen in spr-5 mutants with complete sterility achieved by generation 2 (PubMed:24685137).
messages: Nucleus

6239:CELE Y17G7B.13
gene id: 6239:CELE_Y17G7B.13
uniprot id: Q9XXI1
names: Domain
names: Function
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

6239:CELE F45B8.4
gene id: 6239:CELE_F45B8.4
uniprot id: G5EDE1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the BDU neurons, the touch neurons, the VA, VB and VC motor neurons, two AVF interneurons and unidentified neurons of the retrovesicular ganglion (at protein level).
messages: Expressed in the Pn.aa neuroblasts and in each of their descendant cells, the Pn.aaa, Pn.aap, Pn.aaaa and Pn.aaap cells and the three differentiating neurons generated by each Pn.aa neuroblast; expression is transient, becoming undetectable shortly after the cells are generated in the larval L1 stage (at protein level) (PubMed:11923211). Expressed in the AVM and PVM touch neurons at the L1 larval stage until the early L2 stage (PubMed:9169852). Expressed in the VA and VB motor neurons and their immediate precursors in late L1 to early L2 stage (PubMed:9169852).
messages: May interact with transcription factor unc-3.
messages: Nucleus
messages: Perikaryon
messages: Transcription factor (PubMed:26096732). Plays a role in the determination of neuroblast cell fate and neuronal differentiation (PubMed:11923211, PubMed:26096732). Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, regulating neurosecretion (PubMed:19343207). Negatively modulates the transcription of its own gene, the mechanosensory gene mec-3, and also other touch neuron-specific genes in the BDU neurons; required for coordinated movement (PubMed:9169852, PubMed:8770591, PubMed:26096732). Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 (PubMed:26096732). Acts in concert with non-canonical WNT signaling to negatively modulate transcription of mec-3 gene in BDU neurons (PubMed:26096732). May act in concert with transcription factor unc-3 in motor neuron fate determination (PubMed:18817768). May play a role programmed cell death (PubMed:11923211).
messages: axon

6239:CELE K01C8.3
gene id: 6239:CELE_K01C8.3
uniprot id: Q95ZS2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the group II decarboxylase family.
messages: Cytoplasm
messages: Expressed in UV1 uterine cells in late L4 larval stage.
messages: Expressed in the gonadal sheath projections in between the oocytes, in head RIM motor neurons and RIC interneurons.
messages: Mutants almost completely lack tyramine, have fewer eggs in the uterus and are hyperactive in egg laying in the presence of food with most eggs being laid at the 1-8 cell stage. They also have a reduced backing response, show more spontaneous reversals and fail to suppress head oscillations upon anterior touch.
messages: Perikaryon
messages: Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter (PubMed:15848803). Involved in the regulation of egg laying, which is inhibited by tyramine (PubMed:15848803). Also involved in controlling locomotion and head movements (PubMed:15848803). Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling (PubMed:25723162).
messages: axon

6239:CELE F56F4.3
gene id: 6239:CELE_F56F4.3
uniprot id: A0A7I9IA72
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H06I04.3
gene id: 6239:CELE_H06I04.3
uniprot id: Q5CCJ2
uniprot id: Q9N5N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
messages: nucleolus

6239:CELE F56H6.8
gene id: 6239:CELE_F56H6.8
uniprot id: O45586
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C32E8.7
gene id: 6239:CELE_C32E8.7
uniprot id: P91124
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Expressed in all neurons (PubMed:11029035, PubMed:22654674). Highly expressed in m2 pharyngeal neurons and some pharyngeal interneurons (PubMed:11029035). Also expressed in the excretory canal and the gland cells located just below the nerve ring in the head (PubMed:11029035).
messages: Interacts with the GTPase activator protein tbc-8; the interaction is direct and may be required for the activation of rab-2 and dense vesicle maturation in cholinergic motoneurons (PubMed:22654674). Interacts with rund-1 (PubMed:24698274).
messages: May be involved in neurotransmitter secretion (PubMed:11029035). In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674).
messages: Mutants are resistant to aldicarb, an inhibitor of acetylcholinesterase.

6239:CELE Y69H2.12
gene id: 6239:CELE_Y69H2.12
uniprot id: Q9U1T8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y55F3AM.1
gene id: 6239:CELE_Y55F3AM.1
uniprot id: Q9N361
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE B0361.11
gene id: 6239:CELE_B0361.11
uniprot id: Q7Z118
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

6239:CELE C32F10.6
gene id: 6239:CELE_C32F10.6
uniprot id: Q10902
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE B0304.9
gene id: 6239:CELE_B0304.9
uniprot id: Q3Y412
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T19A6.3
gene id: 6239:CELE_T19A6.3
uniprot id: A5PEW7
uniprot id: Q9XXN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: May form with the serine/threonine protein phosphatase scpl-2 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May play a role in nuclear membrane dynamics being crucial for early development of the embryo.
messages: Membrane
messages: Nucleus membrane
messages: RNAi-mediated knockdown results in the formation of two nuclei in each daughter cell following the first embryonic division.

6239:CELE M176.9
gene id: 6239:CELE_M176.9
uniprot id: A0A0S4FT70
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C33A12.1
gene id: 6239:CELE_C33A12.1
uniprot id: Q18359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

6239:CELE F53A2.8
gene id: 6239:CELE_F53A2.8
uniprot id: G5EBF2
uniprot id: G5ED68
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Expressed in intestinal cells (PubMed:12788949). Expressed in head neurons, pre-anal ganglion, hypodermal cells, anal depressor muscle and non-neuronal cells in the tail (PubMed:25479419).
messages: Heterodimer with mtm-9.
messages: May dephosphorylate phosphatidylinositol-3-phosphate (PI3P) (PubMed:12788949, PubMed:14565969). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969, PubMed:21076391). Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969). Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14 (PubMed:21076391). By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20 (PubMed:21076391). Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development (PubMed:21076391). Involved in the formation of correct synapse number in DA9 motor neurons probably in part by regulating the secretion of Wnt ligand egl-20 (PubMed:25479419).
messages: Membrane
messages: RNAi-mediated knockdown causes an increase in phosphatidylinositol-3-phosphate at the apical plasma membrane of intestinal cells.
messages: The FYVE domain appears to be dispensable for membrane targeting and activity but may be important to increase avidity to membrane.

6239:CELE B0035.10
gene id: 6239:CELE_B0035.10
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE Y48C3A.18
gene id: 6239:CELE_Y48C3A.18
uniprot id: A5HWA9
uniprot id: G2HK06
uniprot id: Q9NAF8
names: Similarity
messages: Belongs to the SUA5 family.

6239:CELE T26C11.7
gene id: 6239:CELE_T26C11.7
uniprot id: Q22812
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CUT homeobox family.
messages: Chromosome
messages: Expressed in embryos (PubMed:17720939). First expressed in the 2 cell stage, with expression increasing at the 8-cell stage, but subsequently decreasing by the 150-cell stage and almost abolished by the 200-cell stage (PubMed:17720939).
messages: Expressed in hermaphrodite gonads.
messages: Nucleus
messages: RNAi-mediated knockdown results in viable hermaphrodites as in wild-type.
messages: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:23666922, PubMed:17720939). Directly binds to 5'-ATTGAT-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922, PubMed:17720939). Associates with condensed DNA during mitosis (PubMed:17720939).

6239:CELE F38E11.1
gene id: 6239:CELE_F38E11.1
uniprot id: Q20164
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE K10C3.4
gene id: 6239:CELE_K10C3.4
uniprot id: O45665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Membrane
messages: extracellular exosome

6239:CELE F33D4.8
gene id: 6239:CELE_F33D4.8
uniprot id: Q688C0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE C34E10.3
gene id: 6239:CELE_C34E10.3
uniprot id: P46578
names: Function
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.
messages: Regulator of mitophagy.

6239:CELE ZC155.5
gene id: 6239:CELE_ZC155.5
uniprot id: H2KZ72
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expression detected in motor neurons.
messages: Interacts with vps-51 and vps-52.
messages: trans-Golgi network

6239:CELE F01G4.3
gene id: 6239:CELE_F01G4.3
uniprot id: Q19103
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE Y71H2AM.25
gene id: 6239:CELE_Y71H2AM.25
uniprot id: Q2AAB9
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C16A3.3
gene id: 6239:CELE_C16A3.3
uniprot id: Q18038
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE T22B11.2
gene id: 6239:CELE_T22B11.2
uniprot id: O44563
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C28H8.4
gene id: 6239:CELE_C28H8.4
uniprot id: Q09473
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity).

6239:CELE F47G4.3
gene id: 6239:CELE_F47G4.3
uniprot id: Q9XTS4
names: Similarity
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Homodimer.

6239:CELE C36E6.1
gene id: 6239:CELE_C36E6.1
uniprot id: Q9BLA0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F20D1.4
gene id: 6239:CELE_F20D1.4
uniprot id: Q93537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

6239:CELE M01F1.7
gene id: 6239:CELE_M01F1.7
uniprot id: G5EED9
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

6239:CELE ZK1290.9
gene id: 6239:CELE_ZK1290.9
uniprot id: Q09336
names: Similarity
messages: Belongs to the FTH family.

6239:CELE Y60A3A.12
gene id: 6239:CELE_Y60A3A.12
uniprot id: Q9U1Y5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.
messages: Highly expressed in germline tissue.
messages: Low expression in embryos and L2 larvae, high expression in hermaphrodite adults.
messages: Nucleus
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.

6239:CELE ZK328.7
gene id: 6239:CELE_ZK328.7
uniprot id: Q20255
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TTC21 family.
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:27515926, PubMed:28479320). In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Functions in cilia biogenesis (PubMed:27515926).
messages: Expressed in ciliated sensory neurons in the head and tail.
messages: Shorter cilia with an irregular morphology resulting in functional defects characterized by defective movement, dauer formation, and mating behavior (PubMed:27515926). Double knockout with intraflagellar transport protein ift-43 results in defective cilium morphology and function (PubMed:28479320).
messages: cilium
messages: cilium basal body
messages: dendrite

6239:CELE Y41D4B.27
gene id: 6239:CELE_Y41D4B.27
uniprot id: A2V8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F45E12.1
gene id: 6239:CELE_F45E12.1
uniprot id: Q20432
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dullard family.
messages: Excess of internal nuclear membranes in oocyte-derived pronuclei that are nearly or completely bisecting the nucleus in embryos during nuclear closure (PubMed:32271860). Increased phosphatidylinositol (PI) production and ectopic ER sheets (PubMed:32271860). Nuclei contain openings through which imported proteins passively diffuse (PubMed:32271860). Increase in embryo nuclear size (PubMed:35852146). Twinned nuclei after mitosis (PubMed:32271860). Simultaneous knockdown of chmp-7 or lem-2 leads to enhanced nuclear sealing defects (PubMed:32271860).
messages: Membrane
messages: Nucleus envelope
messages: Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases (PubMed:22134922). Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (PubMed:22134922). May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics (PubMed:22134922, PubMed:35852146). Contributes to closure of nuclear envelope (NE) holes and prevents excess nuclear membranes after meiosis and mitosis, possibly through spatial regulation of lipin (PubMed:32271860). May limit the production of endoplasmic reticulum (ER) sheets proximal to the NE to prevent the ER membranes that feed into NE openings from invading the nuclear interior and thereby restrict nuclear transport to nuclear pore complexes (NPCs) (PubMed:32271860). May also indirectly regulate the production of lipid droplets and triacylglycerol (PubMed:22134922).

6239:CELE M02H5.5
gene id: 6239:CELE_M02H5.5
uniprot id: Q966H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F48B9.4
gene id: 6239:CELE_F48B9.4
uniprot id: G5EGC3
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Delay in the timing of the reproductive peak of egg-laying.
messages: Expressed in the interneurons BDUL/R, AVG, AIML/R, RIS, AVD and PVT, the chemosensory neuron pairs PHA and PHB, the motor neurons RID and RIML/R, the sensory neurons AQR and PQR, and in the PVPL/R interneurons (PubMed:19686386). Also expressed in rectal gland cells rectD and rectVL/R, the intestino-rectal valve cells virL/R and three posterior arcade cells in the head (PubMed:19686386).
messages: Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor (PubMed:18390545). May not signal through isoform c of pdfr-1 (PubMed:18390545). Involved in locomotion; may play a role in circadian rhythms of locomotor activity (PubMed:18390545, PubMed:22579613, PubMed:26113231). Modulator of egg-laying (PubMed:22579613).

6239:CELE ZK455.1
gene id: 6239:CELE_ZK455.1
uniprot id: Q23500
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (PubMed:12438312). Has probably no RNA-binding activity (PubMed:12438312).
messages: Interacts with gex-3.
messages: cytosol

6239:CELE C02B10.1
gene id: 6239:CELE_C02B10.1
uniprot id: G5EEH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE ZC13.4
gene id: 6239:CELE_ZC13.4
uniprot id: Q95Q39
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in hypodermis first at the two-fold stage and throughout the larval stages but not at the adult stage. Detected in the body seams after the L4 stage with expression maintained in adults. Detected in the male tail structural cells at the late L4 stage and also maintained in adults. Detected at different developmental stages in vulva, PQR neurons and several neuronal processes in the head region.
messages: Plays an important role in determining body shape and sensory ray morphology, possibly by acting as a signaling molecule outside the expressing cell.
messages: The EGF-like domain and the SXC (ShKT) domain are essential for the biological activity of the protein. May function as protein interaction domains.

6239:CELE E04F6.4
gene id: 6239:CELE_E04F6.4
uniprot id: Q19056
names: Similarity
messages: Belongs to the phospholipase D family.

6239:CELE W09C5.6
gene id: 6239:CELE_W09C5.6
uniprot id: Q9U332
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

6239:CELE F31D5.3
gene id: 6239:CELE_F31D5.3
uniprot id: H2KYS8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basal cell membrane
messages: Belongs to the copine family.
messages: Embryos stop elongation at the 2-fold stage and have defects in the organization of the myofibril lattice. pat-3, deb-1, pat-4 and pat-6 are slightly mislocalized in the post 1.5-fold stage. At the 1.5-fold stage, unc-89 and myo-3 localization is normal. However, at the 1.75- and 2-fold stages, unc-89 and myo-3 are mislocalized into large foci within muscle cells.
messages: Expressed in body wall muscles (at protein level).
messages: Expressed in embryos and in adults.
messages: Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin-mediated attachment sites.
messages: M line
messages: May interact (via VWFA domain) with unc-89 (via Ig-like C2-type 1-3) and unc-96 (via C-terminus); cpna-1 binding sites for unc-89 and unc-96 are different. May interact with pat-6. May interact with lim-9 (via LIM domains) and with scpl-1 (via FCP1 homology domain).

6239:CELE F14F8.10
gene id: 6239:CELE_F14F8.10
uniprot id: Q7YTN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F07F6.6
gene id: 6239:CELE_F07F6.6
uniprot id: G5EGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Membrane

6239:CELE T21D12.9
gene id: 6239:CELE_T21D12.9
uniprot id: Q965M2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in the hypodermis.
messages: Expressed in the pharynx from the embryonic stage to adulthood.
messages: Interacts with sma-6 and daf-1.
messages: Small body size phenotype.

6239:CELE C02G6.2
gene id: 6239:CELE_C02G6.2
uniprot id: Q17593
names: Similarity
messages: Belongs to the peptidase M16 family.

6239:CELE C42C1.1
gene id: 6239:CELE_C42C1.1
uniprot id: A3QMB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C34B2.6
gene id: 6239:CELE_C34B2.6
uniprot id: O44952
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mitochondrion (PubMed:22700657).
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown causes transcription factor atfs-1 accumulation in mitochondria.

6239:CELE F40F4.2
gene id: 6239:CELE_F40F4.2
uniprot id: Q20224
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell.
messages: Secreted

6239:CELE C08H9.5
gene id: 6239:CELE_C08H9.5
uniprot id: Q17833
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: By UV irradiation, high temperatures, starvation and old age.
messages: Cell membrane
messages: Increased life span and resistance to UV irradiation and high temperatures.
messages: Receptor tyrosine kinase which plays a role in promoting longevity and resistance to stresses including UV irradiation and high temperatures, probably downstream of daf-16.

6239:CELE F13H10.8
gene id: 6239:CELE_F13H10.8
uniprot id: Q1ZXU7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE C29F3.2
gene id: 6239:CELE_C29F3.2
uniprot id: Q94130
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE C26B2.3
gene id: 6239:CELE_C26B2.3
uniprot id: Q18192
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K07B1.5
gene id: 6239:CELE_K07B1.5
uniprot id: O01882
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE ZK6.6
gene id: 6239:CELE_ZK6.6
uniprot id: B1GRL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE F35G12.9
gene id: 6239:CELE_F35G12.9
uniprot id: Q20052
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RING-box family.
messages: Nucleus
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis (PubMed:11861581). In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity (PubMed:15466891).
messages: RNAi-mediated knockdown is embryonic lethal with the display of a meiotic metaphase-to-anaphase defective phenotype marked by arrest at meiosis I at the one-cell stage of embryogenesis.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3 (Probable). Interacts with ubc-2 (PubMed:15466891).

6239:CELE T28H10.1
gene id: 6239:CELE_T28H10.1
uniprot id: Q22856
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

6239:CELE F53A2.6
gene id: 6239:CELE_F53A2.6
uniprot id: D1MN85
uniprot id: O45551
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasm
messages: Defects can cause a delay in spermatogenesis, temperature-sensitive sterility and defective sperm.
messages: EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners, including pgl-1 (PubMed:11641215). Interacts with ifet-1 (PubMed:19786575).
messages: Enriched in the germline from L3 larvae to adults; regions of the gonad undergoing spermatogenesis. Expressed in germ granules (P granules); when associated with pgl-1.
messages: Expressed both maternally and zygotically. Ubiquitous embryonic expression until the 100-200 cell stage then disappears by the 300-400 cell stage. Expressed again in L3 larvae through to adulthood.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Required for progression through meiotic divisions during spermatogenesis and for the production of viable sperm. It is not required during oogenesis.

6239:CELE F44C8.11
gene id: 6239:CELE_F44C8.11
uniprot id: Q95X91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C28D4.1
gene id: 6239:CELE_C28D4.1
uniprot id: O17611
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F52F12.2
gene id: 6239:CELE_F52F12.2
uniprot id: O02271
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T02B11.5
gene id: 6239:CELE_T02B11.5
uniprot id: O16975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srj family.
messages: Membrane

6239:CELE W01B6.3
gene id: 6239:CELE_W01B6.3
uniprot id: Q23104
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C06A12.4
gene id: 6239:CELE_C06A12.4
uniprot id: Q9XU42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed bilaterally in ASK, ASI and ASJ sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221). Promotes the calcium flux to the cytoplasm in ASJ sensory neurons upon removal of a nitric oxide (NO) stimulus and is thereby involved in the behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE AH6.6
gene id: 6239:CELE_AH6.6
uniprot id: Q09204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F26E4.3
gene id: 6239:CELE_F26E4.3
uniprot id: P90850
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to peptidase C1 family, it lacks the conserved active Cys in position 210, which is replaced by a Ser residue, suggesting that it has no protease activity.
messages: Belongs to the peptidase C1 family.
messages: Secreted

6239:CELE T16G1.10
gene id: 6239:CELE_T16G1.10
uniprot id: Q9XUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

6239:CELE F55H2.6
gene id: 6239:CELE_F55H2.6
uniprot id: P34466
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

6239:CELE K12H4.4
gene id: 6239:CELE_K12H4.4
uniprot id: P34525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).

6239:CELE F09F7.3
gene id: 6239:CELE_F09F7.3
uniprot id: Q27492
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6239:CELE F42G9.2
gene id: 6239:CELE_F42G9.2
uniprot id: P52014
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE H13N06.6
gene id: 6239:CELE_H13N06.6
uniprot id: A0A0K3ATC0
uniprot id: Q9XTQ6
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Membrane
messages: Present in synaptic regions of RIC interneurons. Present in gonadal sheath cells of hermaphrodites (at protein level).
messages: Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter (PubMed:15848803). Involved in the regulation of egg laying, which is inhibited by tyramine (PubMed:15848803). Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity (PubMed:25723162).
messages: Worms are viable and healthy, but have slightly reduced locomotion rates, and defects in the inhibition of pharyngeal pumping and egg laying in the absence of food.

6239:CELE C09E8.1
gene id: 6239:CELE_C09E8.1
uniprot id: H2KYM8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F10C2.5
gene id: 6239:CELE_F10C2.5
uniprot id: P90830
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE C33G8.6
gene id: 6239:CELE_C33G8.6
uniprot id: O76828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE VF39H2L.1
gene id: 6239:CELE_VF39H2L.1
uniprot id: O62387
names: Similarity
messages: Belongs to the syntaxin family.

6239:CELE C33D12.3
gene id: 6239:CELE_C33D12.3
uniprot id: Q21467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F16B4.9
gene id: 6239:CELE_F16B4.9
uniprot id: O44635
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K12H4.1
gene id: 6239:CELE_K12H4.1
uniprot id: P34522
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Prospero homeodomain family.
messages: Expressed in the excretory cell at the 1.5-fold embryonic stage and throughout larval development.
messages: Lethality at larval stage, L1. Surviving animals do not develop into fertile adults. Animals have abnormal sensory function with their bodies harboring lesions and signs of progressive degradation. Defective excretory canal formation with down-regulation of genes, including exc-5, ifb-1, gck-3 and aqp-8, involved in this process. Seventy percent of L1 larvae do not form excretory canals, but have a large vacuole around the excretory cell body. The remaining larvae form impaired excretory canals that rarely extend beyond the pharyngeal-intestinal valve and do not extend to the somatic gonad. Furthermore, some animals develop a cyst in the lumen of the excretory canal. RNAi-mediated knockdown in larvae largely results in arrest at the L1 larval stage. Surviving worms have altered excretory canal growth with a large vacuole and cyst in the excretory cell body and lumen, respectively, and the formation of a thin canal extension.
messages: Nucleus
messages: The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
messages: Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation (PubMed:23334499).

6239:CELE F56A11.1
gene id: 6239:CELE_F56A11.1
uniprot id: O44518
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYFIP family.
messages: Cytoplasm
messages: Embryonic lethal with cells differentiating, but failing to become organized (PubMed:11877381). The external hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). In one study, animals are viable and there is defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). In this same study, double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448).
messages: Interacts with gex-3.
messages: Required for initial steps of body morphogenesis (PubMed:11877381). May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).

6239:CELE Y54E10BR.7
gene id: 6239:CELE_Y54E10BR.7
uniprot id: Q9N3C7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C06A5.11
gene id: 6239:CELE_C06A5.11
uniprot id: Q95Q89
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class IV subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

6239:CELE C08F8.8
gene id: 6239:CELE_C08F8.8
uniprot id: Q9XVV3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in linker cell.
messages: Nucleus
messages: Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-AAGTCA-3' (PubMed:18179707, PubMed:19906858). In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage (PubMed:22363008, PubMed:19906858). Involved in the regulation of non-apoptotic cell death in the linker cell, acting upstream of or in parallel to transcription factor hsf-1 (PubMed:27472063).
messages: RNAi-mediated knockdown in males prevents migration of the linker cell (LC) during larval development resulting in abnormal gonad migration (PubMed:9851916, PubMed:19906858). At the L3-to-L4 molt stage, the LC fails to reach the P7.p hypodermal cell and fails to perform the turn from the dorsal to the ventral side of the body. During the late L4 stage, the LC turns ventrally but stays farther behind its normal position (PubMed:9851916, PubMed:19906858). In addition, LC polarization, which normally occurs during the L3-L4 stages, is severely delayed and mig-2 polarization to the adherent side of thr LC is impaired (PubMed:19906858). In the LC, expression of unc-5 at the L3 and L4 larval stages is increased and expression of zmp-1 is absent at L4 stage (PubMed:19906858). Prevents non-apoptotic cell death in the LC (PubMed:27472063). Knockdown enhances LC survival on egl-20, eor-1, or lin-29 mutant backgrounds (PubMed:27472063). Causes precocious expression of let-70 in the LC during larval stage L3 (PubMed:27472063). RNAi-mediated knockdown in hermaphrodites causes no defect in distal tip cell migration (PubMed:19906858).

6239:CELE Y51A2D.17
gene id: 6239:CELE_Y51A2D.17
uniprot id: G5EEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T12A2.2
gene id: 6239:CELE_T12A2.2
uniprot id: P46975
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal. Embryogenesis proceeds more slowly and embryos are osmo-sensitive.

6239:CELE W02A2.7
gene id: 6239:CELE_W02A2.7
uniprot id: Q9XUB2
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Asymmetrically localized to the anterior of the zygote before mitotic division, then differentially distributed to the somatic blastomere precursor cells.
messages: Cytoplasm
messages: Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581, PubMed:18842813, PubMed:30279189). Also affects formation of intestinal cells (PubMed:10882103). Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA (PubMed:27594427). Required for neg-1 expression in anterior blastomeres during embryogenesis (PubMed:26096734).
messages: Interacts (when phosphorylated on Thr-186) with plk-1 (via POLO box domain) and plk-2 (via POLO box domain).
messages: Phosphorylation on Ser-458 by par-1 promotes localization of the protein to the anterior cytoplasm of the zygote (PubMed:18842813). Phosphorylation by mbk-1 appears to be required for subsequent phosphorylation by plk-1 (PubMed:18199581).
messages: RNAi-mediated knockdown reduces the expression of pie-1 in P2 blastomeres (PubMed:30279189). Abolishes neg-1 expression in anterior blastomeres (PubMed:26096734). RNAi-mediated knockdown in mex-6 pk440 mutant background causes a loss in plk-1 asymmetric distribution during the first embryonic cell divisions.

6239:CELE Y39G10AR.18
gene id: 6239:CELE_Y39G10AR.18
uniprot id: Q6AW06
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Chromosome
messages: Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes (PubMed:23806335). Involved in controlling tissue-specific gene expression, particularly in the epidermis (PubMed:31088904).
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Interacts with zfp-1 (via C-terminus) to form a heterodimer known as the zfp-1-dot-1.1 complex or DotCom complex.
messages: Nucleus
messages: RNAi-mediated knockdown results in the ectopic expression of the neuronal identity-inducing transcription factor che-1 in the epidermis.

6239:CELE D1054.2
gene id: 6239:CELE_D1054.2
uniprot id: Q27488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE M01G12.4
gene id: 6239:CELE_M01G12.4
uniprot id: O62311
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y55F3AR.1
gene id: 6239:CELE_Y55F3AR.1
uniprot id: Q9N356
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58A4.9
gene id: 6239:CELE_F58A4.9
uniprot id: P34476
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: Nucleus

6239:CELE T14F9.4
gene id: 6239:CELE_T14F9.4
uniprot id: A0A5S9MMK5
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed widely throughout development (at protein level) (PubMed:11203704). Earliest expression at the embryonic comma stage; expressed in the developing pharynx, hypodermal cells, hindgut lining, and also in several cells near the rectum and in the tail (at protein level) (PubMed:11203704, PubMed:15581870). Expressed in pharynx until adulthood, when it becomes undetectable (at protein level) (PubMed:11203704). Expression in adult hermaphrodites may be highest in the germ line (PubMed:11203704).
messages: May not bind metals in vitro (PubMed:15165844). It is possible that some phenotypes due to mutant cu9 allele are due to deletion of predicted flanking non-coding RNA genes.
messages: Nucleus
messages: Putative transcription factor (PubMed:11203704). Binds to specific sequence motif 5'-[TC][AGT]TGCC[GA][AT]-3' in regulatory elements of target genes such as myosin myo-2 (PubMed:11203704, PubMed:15165844). May modulate gene expression, perhaps acting in opposition to transcription factor pha-4 (PubMed:11203704, PubMed:12095247). Involved in morphogenesis, perhaps especially in formation of the pharynx (PubMed:11203704, PubMed:15581870). Plays roles in molting, feeding and morphology (PubMed:15581870).
messages: RNAi-mediated knockdown causes multiple defects, including embryonic lethality, slow larval growth, abnormal tail morphology, constipation, abnormal vulva, and abnormal pharynx.

6239:CELE R12H7.3
gene id: 6239:CELE_R12H7.3
uniprot id: G5EC92
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE Y57G7A.4
gene id: 6239:CELE_Y57G7A.4
uniprot id: O76620
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K01H12.3
gene id: 6239:CELE_K01H12.3
uniprot id: Q21104
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W03G11.1
gene id: 6239:CELE_W03G11.1
uniprot id: Q23150
uniprot id: Q2XN04
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZC518.3
gene id: 6239:CELE_ZC518.3
uniprot id: G5EE09
uniprot id: Q9U1P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

6239:CELE Y105E8B.2
gene id: 6239:CELE_Y105E8B.2
uniprot id: Q95Q35
names: Similarity
messages: Belongs to the EXO84 family.

6239:CELE C47B2.5
gene id: 6239:CELE_C47B2.5
uniprot id: O62106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing (PubMed:17507929).
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

6239:CELE C50H2.1
gene id: 6239:CELE_C50H2.1
uniprot id: G5EG04
uniprot id: L8EC40
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C12D5.11
gene id: 6239:CELE_C12D5.11
uniprot id: Q8I7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE B0546.1
gene id: 6239:CELE_B0546.1
uniprot id: O44441
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mai-2 and tin-9.2 are transcribed on a dicistronic transcript where exos-4.1 is the upstream transcript and tin-9.2 the downstream.
messages: Mitochondrion
messages: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent.

6239:CELE T12D8.8
gene id: 6239:CELE_T12D8.8
uniprot id: G5EE04
names: Similarity
messages: Belongs to the FAM10 family.

6239:CELE ZK1025.7
gene id: 6239:CELE_ZK1025.7
uniprot id: Q9XXM0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE B0432.5
gene id: 6239:CELE_B0432.5
uniprot id: P90986
uniprot id: S6FN11
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Expressed in dopaminergic cells. Expressed in neurons in the head and middle body of the hermaphrodite, and six neurons in the tail of the male.
messages: Inhibited by dopamine with an IC(50) of 32.6 uM for the unphosphorylated form and 43.4 uM for the phosphorylated form (PubMed:21087208). Phosphorylation leads to an increase in the catalytic activity (By similarity).
messages: Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior. In response to food, involved in promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons (PubMed:19609300). Modulates male mating behavior by controlling the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location (PubMed:23166505).
messages: Plays a role in promoting amphetamine-induced loss of motility in water, termed swimming-induced paralysis.
messages: Reduced (30-40% of wild type) level of dopamine thought to be due to defects in dopamine synthesis. Defects in serotonin signaling. Affects mechanosensory behavior including foraging and exploration activity. Hypersensitivity to odorants. Blocks the enhanced slowing response phenotype caused by bilobalide, a neuroprotective plant chemical. No significant effect on lifespan.
messages: axon
messages: perinuclear region

6239:CELE Y37H9A.6
gene id: 6239:CELE_Y37H9A.6
uniprot id: Q9U2M7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
messages: Belongs to the Nudix hydrolase family.
messages: Divalent metal ions. Mg(2+), Co(2+), Mn(2+), Zn(2+) or Ca(2+).
messages: Monomer.
messages: Mutagenesis suggests that interactions with P1- and P4-phosphate are minimum indicating the enzyme may have a wide substrate range.

6239:CELE F26A3.6
gene id: 6239:CELE_F26A3.6
uniprot id: Q93597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C12D12.2
gene id: 6239:CELE_C12D12.2
uniprot id: Q10901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane
messages: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity).

6239:CELE F23F1.8
gene id: 6239:CELE_F23F1.8
uniprot id: O17071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

6239:CELE R13H8.1
gene id: 6239:CELE_R13H8.1
uniprot id: O16850
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Dauer defective phenotype in larvae and a reduced stress phenotype in adults (PubMed:9360933). Increased carbonyl accumulation and increased sensitivity to starvation (PubMed:18025456). Increased expression of the srh-234 chemoreceptor during starvation (PubMed:25357003). Increased sensitivity to physical injury and more susceptible to death by nematophagous fungal infection (PubMed:24146615). Increased lifespan (PubMed:23805378). Causes a delay in apoptosis during embryonic development (PubMed:25383666). Defective gustatory associative learning in response to salt cues (PubMed:30779740). RNAi-mediated knock-down reduces expression of daf-16 target genes and genes up-regulated in response to nematophagous fungal infection such as sod-3 (PubMed:24146615). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:17900900). Simultaneous RNAi-mediated knockdown of metalloproteinase zmp-2 restores normal survival upon heat stress and prevents increased susceptibility to heat stress in a daf-9 or daf-12 mutant background (PubMed:24957743). RNAi-mediated knockdown in a daf-2 (e1370) mutant background restores expression of deubiquitinase ubh-4 in the intestine (PubMed:23770237). RNAi-mediated knockdown suppresses the decreased number of mitotic nuclei in the germline of developing larvae in an atg-18 (gk378) or atg-16.2 (ok3224) mutant background. Suppresses associative memory, axon regeneration and fkh-9 transcript levels, in a daf-2 mutant background. RNAi-mediated knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229).
messages: Expressed in embryos, larvae, dauer larvae and adults.
messages: Expression increases substantially with age.
messages: Expression throughout the body increases slightly with age.
messages: Forkhead-type transcription factor (PubMed:9360933). Binds to the promoters of genes that contain the daf-16/FOXO binding element (DBE), TTGTTTAC, in their regulatory region (PubMed:10880363, PubMed:23770237, PubMed:26675724). Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, sleep, associative memory, and dauer formation (PubMed:9360933, PubMed:8247153, PubMed:11747821, PubMed:11747825, PubMed:11381260, PubMed:14622602, PubMed:12750521, PubMed:17900900, PubMed:18358814, PubMed:18762027, PubMed:18832074, PubMed:19103192, PubMed:21531333, PubMed:22081913, PubMed:29523076, PubMed:26675724). Longevity signaling predominantly arises from expression in the intestine (PubMed:14622602). Transcriptional activity of daf-16/FOXO is negatively regulated by interaction with host cell factor homolog hcf-1; and by cytoplasmic sequestration by association with ftt-2 (PubMed:11381260, PubMed:21531333, PubMed:18828672). Inhibition is required for the carbon dioxide (CO2) avoidance response (PubMed:18524954). Upon loss of inhibition, daf-16 translocates to the nucleus to regulate genes that result in delayed reproduction and growth while increasing stress resistance starvation tolerance and longevity (PubMed:11747825, PubMed:21531333). Association with arginine methyltransferase prmt-1 prevents phosphorylation and allows for translocation to the nucleus and the subsequent transcription of longevity-related genes (PubMed:21531333). Modulation of its activity by cGMP levels in sensory neurons regulates lifespan (PubMed:19489741). Has a protective role against muscle dystrophy (PubMed:18397876). Involved in mediating protection against aberrant protein aggregation proteotoxicity (PubMed:16902091). Influences transcription of genes that code for proteins involved in immunity as part of a general stress response (PubMed:17096597, PubMed:18245330). Targets genes that inhi…
messages: Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345). May play a role in lifespan modulation, but less significant than that played by isoforms d and f (PubMed:24834345).
messages: Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345). Transcript level in the early adult may play a role in lifespan modulation, but effect is more significant than that played by isoform a (PubMed:24834345).
messages: Induced by quinic acid.
messages: Interacts with rle-1 (PubMed:17276341). Interacts with unc-43 and tax-6 (PubMed:23805378). Interacts with jnk-1 (PubMed:15767565). Interacts with ftt-2 (PubMed:16777605, PubMed:21531333). Interacts with prmt-1 (PubMed:21531333). Interacts with hcf-1.
messages: Isoform b and isoform c are expressed in ectoderm, muscles, intestine and neurons (PubMed:9353126, PubMed:11747825, PubMed:14622602, PubMed:17894411). Isoform b is also expressed in the pharynx (PubMed:11747821). The intestine appears to be the primary site of longevity function (PubMed:14622602).
messages: Methylation by prmt-1 prevents phosphorylation and promotes translocation to the nucleus to allow for daf-16-dependent transcription.
messages: Nucleus
messages: Phosphorylated by akt-1 and/or akt-2 (PubMed:18358814, PubMed:21531333). Phosphorylated by sgk-1 (PubMed:18358814). Phosphorylated by unc-43 (PubMed:23805378). Phosphorylated by jnk-1 (PubMed:15767565). Dephosphorylated by tax-6 in vitro (PubMed:23805378).
messages: Ubiquitinated. Ubiquitination by rle-1 leads to proteasome-mediated degradation.

6239:CELE E02H1.1
gene id: 6239:CELE_E02H1.1
uniprot id: Q09522
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

6239:CELE B0511.9
gene id: 6239:CELE_B0511.9
uniprot id: G4RT11
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC26 family.
messages: Nucleus
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. Required for embryonic anterior-posterior axis formation.
messages: RNAi-mediated knockdown results in arrest at metaphase during meiosis I in early embryos. Defective embryonic polarity due to improper first cell division.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE F15D3.7
gene id: 6239:CELE_F15D3.7
uniprot id: Q9XVQ2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54G8.5
gene id: 6239:CELE_F54G8.5
uniprot id: Q03602
names: Similarity
messages: Belongs to the patched family.

6239:CELE F55H12.1
gene id: 6239:CELE_F55H12.1
uniprot id: P90890
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C18E9.4
gene id: 6239:CELE_C18E9.4
uniprot id: Q18095
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

6239:CELE T04A8.16
gene id: 6239:CELE_T04A8.16
uniprot id: Q22143
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE C54D10.3
gene id: 6239:CELE_C54D10.3
uniprot id: Q18827
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F46C5.3
gene id: 6239:CELE_F46C5.3
uniprot id: Q20459
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal muscles, pharyngeal-intestinal valve, rectal gland cells and arcade cells.
messages: Metalloprotease.
messages: Secreted

6239:CELE ZK697.7
gene id: 6239:CELE_ZK697.7
uniprot id: A0A0K3AW74
uniprot id: O61200
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F37A4.5
gene id: 6239:CELE_F37A4.5
uniprot id: P41883
names: Similarity
messages: Belongs to the peptidase M67A family.

6239:CELE Y40H4A.1
gene id: 6239:CELE_Y40H4A.1
uniprot id: Q9U7D5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Isoform a and isoform b are expressed at all developmental stages examined, isoform a is more abundant at embryonic and early larval stages and isoform b at first larval instar.
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins (PubMed:10635059, PubMed:12927813). Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion (PubMed:18614679).

6239:CELE F25H5.6
gene id: 6239:CELE_F25H5.6
uniprot id: O17839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

6239:CELE R01H2.6
gene id: 6239:CELE_R01H2.6
uniprot id: Q21633
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Expressed in neurons localized in the head and tail of adults.
messages: Interacts with E3 ubiquitin-protein ligase wwp-1 (PubMed:19553937). Interacts with RBR-type E3 ubiquitin transferase ari-1.1 (PubMed:16457801).
messages: RNAi-mediated knockdown very slightly reduces viability and brood size; phenotype is exacerbated on a mutant background which enhances the overall efficacy of RNAi (PubMed:12783801). Increases sensitivity to paraquat and reduces lifespan at 25 degrees Celsius, but not at 20 degrees Celsius (PubMed:19553937). Abolishes lifespan extension completely on an eat-2 mutant background (PubMed:19553937). Substantially increases embryonic expression of sup-35 (PubMed:19521497).
messages: Ubiquitin-conjugating enzyme E2 (PubMed:19553937). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19553937). Required for diet restriction-mediated lifespan extension, probably acting as part of a complex with ubiquitin-protein ligase wwp-1 (PubMed:19553937). Acts redundantly with lin-35/Rb in the regulation of pharyngeal morphogenesis during embryonic development by negatively regulating the expression of proteins such as sup-35 (PubMed:12783801, PubMed:19521497).

6239:CELE C52B9.6
gene id: 6239:CELE_C52B9.6
uniprot id: Q22940
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE D2023.6
gene id: 6239:CELE_D2023.6
uniprot id: O17735
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

6239:CELE Y116A8C.24
gene id: 6239:CELE_Y116A8C.24
uniprot id: H8ESG3
uniprot id: Q9U2U8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE ZK384.6
gene id: 6239:CELE_ZK384.6
uniprot id: G5EC01
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE F10C5.2
gene id: 6239:CELE_F10C5.2
uniprot id: Q19293
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (PubMed:32923640).
messages: Nucleus inner membrane

6239:CELE C05D11.7
gene id: 6239:CELE_C05D11.7
uniprot id: Q11186
uniprot id: Q8T3F2
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707). Promotes fat oxidation in response to mitochondrial stress (PubMed:33078707). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (PubMed:19052547, PubMed:20176933, PubMed:24120942, PubMed:25202121, PubMed:26083785, PubMed:26098762). Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues (PubMed:25202121). Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during the dauer phase in response to phosphorylation by ampk (PubMed:19052547, PubMed:26083785, PubMed:26098762). May regulate serotonin-mediated lipolysis in metabolic tissues (PubMed:24120942).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the hypodermis (PubMed:19052547, PubMed:26098762). Expressed in the intestine (at protein level) (PubMed:24120942, PubMed:33078707).
messages: Interacts with par-5 (PubMed:26098762). Interacts with lid-1 (PubMed:25202121). Interacts with cgi-58 (PubMed:26083785).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid droplet
messages: May be induced by serotonin.
messages: Phosphorylation at Ser-303 by aak-2 results in possible instability and cytoplasmic accumulation during the dauer phase.
messages: RNAi-mediated knockdown reduces stored lipid droplet hydrolysis during fasting resulting in retained/increased lipid droplets and there are also increased lipid droplets in the fed state (PubMed:24120942, PubMed:25202121). Suppresses fasting-induced oxygen consumption (PubMed:25202121). RNAi-mediated knockdown abrogates the increased fat loss and increased oxygen consumption rate observed in the hlh-11 ok2944 mutant (PubMed:33078707). RNAi-mediated knockdown also abrogates the increased fat loss observed following overexpression of flp-7 (PubMed:28128367, PubMed:33078707). Furthermore, RNAi-mediated knockdown reduces the induction of hsp-60, an indicator of mitochondrial stress following overexpression of either flp-7 or hlh-11 (PubMed:33078707). RNAi-mediated knockdown in aak-2 mutants improves the survival of dauer larvae (PubMed:19052547). RNAi-mediated knockdown in daf-2 constitutive dauer phase mutants results in enlarged lipid droplets possibly due to an accumulation of unhydrolyzed triglycerides (PubMed:26098762).
messages: Ubiquitinated (PubMed:25202121, PubMed:26098762). Ubiquitination may decrease upon phosphorylation by kin-1 (PubMed:25202121).

6239:CELE K08F4.11
gene id: 6239:CELE_K08F4.11
uniprot id: O16116
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE F53B3.2
gene id: 6239:CELE_F53B3.2
uniprot id: Q20710
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE T03F1.8
gene id: 6239:CELE_T03F1.8
uniprot id: A5HU98
uniprot id: P91425
names: Similarity
messages: Belongs to the guanylate kinase family.

6239:CELE C54F6.9
gene id: 6239:CELE_C54F6.9
uniprot id: O16442
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y54G2A.1
gene id: 6239:CELE_Y54G2A.1
uniprot id: G5EF76
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed mostly in the seam (stem) cells and hypodermis (hyp7), but also to a lesser extent in the intestine.
messages: Nucleus
messages: Probable transcription factor (PubMed:9247331, PubMed:29108019). During development, required for cell fate specification, probably by promoting or repressing expression of genes involved in specific cell fate (PubMed:9247331, PubMed:29108019). Involved in specifying lineages derived from the epidermal stem cells of the lateral ectoderm, known as seam cells (PubMed:9247331, PubMed:29108019). Modulates symmetric divisions of seam cells, perhaps in concert with the Wnt signaling pathway (PubMed:29108019). May repress expression of homeobox genes mab-5, egl-5 and lin-39 (PubMed:9247331).
messages: RNAi-mediated knockdown leads to an increase in seam (stem) cell number variability.

6239:CELE T17E9.2
gene id: 6239:CELE_T17E9.2
uniprot id: P46548
uniprot id: Q95ZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm

6239:CELE Y110A7A.8
gene id: 6239:CELE_Y110A7A.8
uniprot id: Q9N592
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

6239:CELE F42H10.5
gene id: 6239:CELE_F42H10.5
uniprot id: P34418
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Defective cessation of distal tip cell migration from the dorsal muscle towards the mid-body during gonadal development. RNAi-mediated knockdown of cacn-1 in mig-39 null animals results in a strong overshoot phenotype in which anterior and posterior distal tip cells. RNAi-mediated knockdown of Rac GTPase, Rac-2, in double mig-39 and either ced-10 or mig-2 (which are also Rac GTPases) null animals, suppresses the overshoot phenotype in mig-39 null animals.
messages: Expressed in distal tip cells and in germline cells.
messages: Expressed in the nucleus of distal tip cells until larval stage L4 when expression decreases onwards to late adulthood.
messages: Nucleus
messages: Regulates the timing and orientation of distal tip cell migration during gonadal development. May act in parallel to cacn-1 and Rac GTPases to control the anterior and posterior migration of distal tip cells.

6239:CELE Y71F9AL.16
gene id: 6239:CELE_Y71F9AL.16
uniprot id: Q9N4I0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP3 subfamily.
messages: Component of the Arp2/3 complex, at least composed of arx-1, arx-2, arx-4 and arx-6.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). Plays a role in time-dependent memory loss and the retention of conditioned behavior over time (PubMed:24630719).
messages: RNAi-mediated knockdown suppresses the memory retention defects of the msi-1 os1 loss of function mutant.
messages: cytoskeleton

6239:CELE F41G3.21
gene id: 6239:CELE_F41G3.21
uniprot id: Q4TTB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F42G10.2
gene id: 6239:CELE_F42G10.2
uniprot id: Q20347
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology (PubMed:15707898). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Cytoplasm
messages: Defective extension of body wall muscle connections or arms towards the ventral nerve cord. Double knockout with madd-3 results in severe muscle arm extension defects.
messages: Expressed in the pharynx, including the corpus, isthmus and terminal bulb.

6239:CELE K06C4.3
gene id: 6239:CELE_K06C4.3
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C02F5.12
gene id: 6239:CELE_C02F5.12
uniprot id: Q95QY7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F07H5.2
gene id: 6239:CELE_F07H5.2
uniprot id: Q19185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

6239:CELE R07E3.4
gene id: 6239:CELE_R07E3.4
uniprot id: Q21809
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE C52B9.9
gene id: 6239:CELE_C52B9.9
uniprot id: O45873
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE K05C4.1
gene id: 6239:CELE_K05C4.1
uniprot id: Q9XUV0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins (PubMed:27528192). This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity).
messages: Cytoplasm
messages: No visible phenotype. Constitutive skn-1-dependent expression of the proteasomal subunit rpt-3. Double knockout with ddi-1, sel-1, sel-9, png-1 or skn-1a results in failed expression of the proteasomal subunit rpt-3.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

6239:CELE T03D8.7
gene id: 6239:CELE_T03D8.7
uniprot id: Q9XTY0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T06D8.5
gene id: 6239:CELE_T06D8.5
uniprot id: Q22251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

6239:CELE R02D3.1
gene id: 6239:CELE_R02D3.1
uniprot id: O44503
uniprot id: U4PFH6
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

6239:CELE K08E3.8
gene id: 6239:CELE_K08E3.8
uniprot id: Q9XUS2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 29 family.
messages: Component of the Mediator complex (By similarity). May interact with sel-7 and sel-8 (PubMed:15020414).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes (By similarity). Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery (By similarity). Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Involved in development of gonad and seam cells (PubMed:19500563, PubMed:15020414). Plays a role in temporal regulation of seam cell division, probably acting as a part of the Mediator complex (PubMed:19500563).
messages: Nucleus
messages: RNAi-mediated knockdown has no effect on seam cell division or differentiation, but in a sel-7 mutant background decreases number of seam cells (PubMed:19500563). Partially suppresses the hermaphrodite gonadal development defect in a lin-12 mutant background (PubMed:15020414).

6239:CELE K08D10.8
gene id: 6239:CELE_K08D10.8
uniprot id: Q21318
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE F11G11.11
gene id: 6239:CELE_F11G11.11
uniprot id: P91249
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K11D2.5
gene id: 6239:CELE_K11D2.5
uniprot id: Q7YTL5
names: Similarity
messages: Belongs to the mTERF family.

6239:CELE C35C5.2
gene id: 6239:CELE_C35C5.2
uniprot id: Q93332
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

6239:CELE M01B12.5
gene id: 6239:CELE_M01B12.5
uniprot id: O44959
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Cytoplasm
messages: Expressed in the nervous system at all larval stages. Expressed in somatic gonad and in the ventral nerve cord at L2 larval stage. Expressed in somatic gonad, in ventral uterine (VU/AC) cells and in the committed anchor cell at L3 larval stage. Expressed in vulF cells of the vulva, uterine cells and in uterine seam cells (utse) at L4 larval stage.
messages: Expressed in vulva and uterine cells, uterine seam cells (utse), spermatheca and in the nervous system including chemosensory neurons in the head, nerve ring neurons (RID/RIF), inhibitory motor neurons (DA/DD/VA/VD), mechanosensory neurons (ALML/PLML) and tail sensory neurons (DVA//PDA) (PubMed:24929033, PubMed:25688864). Also expressed in intestine and pharynx (procorpus) and rectal valve and gland (PubMed:25688864).
messages: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oogenesis by regulating germ cell proliferation, progression through diplotene and diakinesis stages and oocyte maturation (PubMed:24929033, PubMed:25688864). Regulates germline development probably by regulating the phosphorylation of mpk-1 (PubMed:25688864). Involved in larval development (PubMed:24929033, PubMed:25688864).
messages: RNAi-mediated knockdown causes early larval arrest. In adults, results in sterility. Causes malformations of the gonad arms (empty or misshaped) and a protruding vulva (PubMed:24929033). Abnormal germline development characterized by a decrease in the number of proliferating germ cells in the mitotic and transition zones. At the diplotene stage, cells are disorganized and have enlarged nuclei. Oocytes have abnormal shape and large DNA aggregates next to abnormally located sperm. In addition, 50 percent of cells fails to decrease mpk-1 phosphorylation upon pachytene stage exit (PubMed:24929033, PubMed:25688864). RNAi-mediated knockdown in a let-60 n1046 mutant background suppresses the formation of multivulva (PubMed:24929033).

6239:CELE R11G11.5
gene id: 6239:CELE_R11G11.5
uniprot id: O16957
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F48D6.3
gene id: 6239:CELE_F48D6.3
uniprot id: Q20561
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in hermaphrodite dopaminergic neurons (ADE, CEP, and PDE).
messages: Expressed throughout development and adulthood but abundance declines with age.
messages: Faster exit from L1 arrest and IIS-dependent dauer diapause.
messages: Induced by daf-16.
messages: Nucleus
messages: Transcriptional activator (By similarity). Shown to have a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling). Hypodermal expression is regulated by IIS/daf-16 while neuronal expression is not under the control of IIS/daf-16.

6239:CELE F45G2.8
gene id: 6239:CELE_F45G2.8
uniprot id: O62250
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and dnj-21/tim-14. Associates with the TIM23 complex.
messages: Regulates ATP-dependent protein translocation into the mitochondrial matrix.
messages: The J-like region, although related to the J domain does not have co-chaperone activity.

6239:CELE T05A10.1
gene id: 6239:CELE_T05A10.1
uniprot id: Q7JM44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at larval L1 and L3 stages and in adulthood.
messages: Expressed from larval stage L1 to adult stages but not during embryonic development.
messages: Expressed in the ventral nerve cord (VNC), pharynx, intestine and seam cells (at protein level).
messages: Induced by exposure to nano-polystyrene particles.
messages: Nucleus
messages: RNAi-mediated knockdown causes a reduction in acetylcholine (ACh) content, altered sensitivity to Aldicarb, a potent acetylcholinesterase (AChE) inhibitor, reduced expression of vesicular acetylcholine transporter unc-17 and elevated levels of reactive oxygen species (PubMed:25407930). Knockdown inhibits nuclear localization of transcription factor daf-16 (PubMed:25407930). In response to nano-polystyrene, causes decreased locomotion behavior and increased reactive oxygen species (ROS) production (PubMed:20687916). Intestine-specific RNAi-mediated knockdown causes increased ROS production and reduces expression of elt-2 and hsp-6 (PubMed:20687916). Represses the mitochondrial unfolded protein response (mtUPR) induced by exposure to nano-polystyrene (PubMed:20687916).
messages: Transcription factor, probably acting as a transcriptional activator (PubMed:17397820). Required for patterning of male-specific genital sensilla (simple sense organs), known as rays (PubMed:20565799). Dispensable for regulation of body size (PubMed:20565799).
messages: Transcription factor, probably acting as a transcriptional activator and repressor, involved in the TGF-beta-like dbl-1 signaling pathway (PubMed:14627718, PubMed:17397820, PubMed:20687916). Plays a role in regulation of body size, and patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules (PubMed:14627718). Required for the dorsoventral patterning of the postembryonic mesodermal lineage (M lineage), acting by antagonizing the TGF-beta-like dbl-1 signaling pathway, in part by repressing expression of transcription factor unc-130 (PubMed:16790477, PubMed:18036582, PubMed:29155044). Involved in egg-laying, perhaps via modulation of cholinergic neurotransmission (PubMed:25407930). Involved in production of reactive oxygen species (ROS), acting downstream of the dbl-1 signaling pathway (PubMed:20687916). Plays a role in the mitochondrial unfolded protein response (mtUPR) (PubMed:20687916). May play a role in modulating lifespan and in responses to proteotoxic stress (PubMed:25407930).

6239:CELE H28G03.6
gene id: 6239:CELE_H28G03.6
uniprot id: Q9TXP3
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1284 in the dsPTPase catalytic loop and does not have phosphatase activity (By similarity). The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Probably acts as an adapter for other myotubularin-like phosphatases (Probable).
messages: RNAi-mediated knockdown causes no obvious phenotype.

6239:CELE K02B2.3
gene id: 6239:CELE_K02B2.3
uniprot id: Q21121
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region (residues 293-316): while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core, which may contribute to stabilizing the transmembrane pore structure. The transmembrane pore is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH), which contains a kink around Glu-204 and interacts with the IJMH.
messages: Inhibited by ruthenium red or its derivative Ru360; possibly by obstructing the pore.
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:25313960, PubMed:31983639). Constitutes a pore-forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding (PubMed:25313960). In addition, together with mitochondrial calcium regulator micu-1, required for mitochondrial calcium uptake following axon injury in PLM touch receptor neurons (PubMed:31983639).
messages: Mitochondrion inner membrane
messages: Null mutants are viable and fertile, but have strongly impaired mitochondrial calcium uptake following laser or needle wounding (PubMed:25313960). Reduces the wound-induced transient elevations in mitochondrial reactive oxygen species superoxide (which are known as mitochondrial flashes or mitoflashes) (PubMed:25313960). Double knockout with the srb-13 xm1 mutant suppresses the sperm navigation defect in the srb-13 single mutant (PubMed:28662030).
messages: The critical DXXE motif connecting the transmembrane regions forms a pentameric barrel that constitutes the mouth of the pore. Inside the barrel, both acidic residues are in position to form two carboxylate rings: the Asp-240 ring is solvent exposed, and the Glu-243 ring is located deeper, guarding the entrance of the second transmembrane pore. In absence of emre-1 regulator, the calcium ions cannot exit the channel, suggesting that emre-1-binding induces conformational rearrangements to allow calcium to exit.

6239:CELE M01D7.2
gene id: 6239:CELE_M01D7.2
uniprot id: G5EED5
uniprot id: X5M5X6
uniprot id: X5M914
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C27A7.6
gene id: 6239:CELE_C27A7.6
uniprot id: G5ED11
uniprot id: H9G2Z4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F44C4.2
gene id: 6239:CELE_F44C4.2
uniprot id: Q20389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F10D2.6
gene id: 6239:CELE_F10D2.6
uniprot id: O16915
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y44A6B.4
gene id: 6239:CELE_Y44A6B.4
uniprot id: O62448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C17E7.3
gene id: 6239:CELE_C17E7.3
uniprot id: A0A163UT97
uniprot id: O16394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE AH6.10
gene id: 6239:CELE_AH6.10
uniprot id: Q09208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C44E4.5
gene id: 6239:CELE_C44E4.5
uniprot id: A6PVA1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE Y39A3B.5
gene id: 6239:CELE_Y39A3B.5
uniprot id: B2L045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE K08E7.9
gene id: 6239:CELE_K08E7.9
uniprot id: P34712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
messages: Intestinal cells.
messages: Membrane

6239:CELE Y37D8A.1
gene id: 6239:CELE_Y37D8A.1
uniprot id: Q9XWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

6239:CELE F31D5.2
gene id: 6239:CELE_F31D5.2
uniprot id: Q19932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE E04F6.14
gene id: 6239:CELE_E04F6.14
uniprot id: Q95QP1
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C13C4.5
gene id: 6239:CELE_C13C4.5
uniprot id: O01927
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE F55A12.4
gene id: 6239:CELE_F55A12.4
uniprot id: O01758
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE M176.2
gene id: 6239:CELE_M176.2
uniprot id: Q21549
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

6239:CELE T07A9.5
gene id: 6239:CELE_T07A9.5
uniprot id: O44406
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the ERI/DICER complex at least composed of dcr-1, rrf-3 and eri-1.
messages: Cytoplasm
messages: Expressed in the somatic developing gonads and in a subset of neurons. In adults, it is specifically expressed in neurons and in spermatheca.
messages: Interacts with pir-1.
messages: RNA exonuclease that acts as a negative regulator of RNA interference (RNAi) (PubMed:14961122). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs) (PubMed:14961122). Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable).

6239:CELE R11A5.7
gene id: 6239:CELE_R11A5.7
uniprot id: Q9XU75
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Cytoplasmic vesicle
messages: Expressed from the 3-fold embryonic stage to young adult and at the larval stage in hypodermal and intestinal cells.
messages: Localizes in stripes along the cuticle.
messages: May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19.
messages: RNAi-mediated knockdown results in a slightly shorter and stouter body.
messages: Secreted
messages: The ShKT and Thr-rich domains are required for body morphogenesis.

6239:CELE F56B6.4
gene id: 6239:CELE_F56B6.4
uniprot id: H2KYQ5
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
messages: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.
messages: Forms a heterooctamer with one molecule of gyg-1 bound to each protomer of the gys-1 homotetramer. The N-terminus of gys-1 is involved in interprotomer contacts with gyg-1. The interaction with gys-1 is required for glycogen production but is not required for gys-1 intrinsic activity.
messages: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for gsy-1.
messages: Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-194.
messages: The length of the linker region between residues 387-394 which separates two alpha-helices regulates the size of the glycogen particles synthesized but plays no role in the interaction with gsy-1.

6239:CELE C52E4.1
gene id: 6239:CELE_C52E4.1
uniprot id: P25807
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Activated by a GATA-like transcription factor.
messages: Belongs to the peptidase C1 family.
messages: Larvae and adults, but not in embryos.
messages: Larvae exhibit strong expression in gut cells and weak expression in hypodermal cells. Adults exhibit the reverse: strong expression in hypodermal cells and weaker expression in gut cells.
messages: Thiol protease. Has a role as a digestive enzyme.

6239:CELE C53A5.5
gene id: 6239:CELE_C53A5.5
uniprot id: D5MCU0
uniprot id: O17697
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T22G5.2
gene id: 6239:CELE_T22G5.2
uniprot id: O02323
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE Y40B1B.6
gene id: 6239:CELE_Y40B1B.6
uniprot id: Q9XWP6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Expressed throughout the development. Expressed in embryos, L1, L2, L3 and L4 larval stages and in adults.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor (PubMed:34329293). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). May be involved in H3 demethylation in mitotic cells including gut and embryonic cells (PubMed:34329293). Participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12411496). May act via the formation of a multiprotein complex that remodel or modify the chromatin (PubMed:12381669). Together with met-2, set-17 and set-26, required for transgenerational fertility (PubMed:24685137). Plays a role in developmental growth and lifespan regulation in response to ultraviolet-induced damage (PubMed:33046905).
messages: Nucleus
messages: Probably part of a large repressor complex (PubMed:12411496). Interacts with CoREST protein spr-1 (PubMed:12411496). Interacts with chromobox protein homolog hpl-1 (PubMed:26476455).
messages: Progressive loss of fertility and accumulation of histone H3 'Lys-4' dimethylation (H3K4me2) over generations (PubMed:24685137). Suppression of sel-12 mutant phenotypes, possibly by up-regulating hop-1 expression (PubMed:12411496).

6239:CELE T05B11.3
gene id: 6239:CELE_T05B11.3
uniprot id: P90961
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

6239:CELE F11A3.1
gene id: 6239:CELE_F11A3.1
uniprot id: Q19339
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE R166.2
gene id: 6239:CELE_R166.2
uniprot id: Q22003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

6239:CELE R05G6.6
gene id: 6239:CELE_R05G6.6
uniprot id: Q21751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE H14E04.5
gene id: 6239:CELE_H14E04.5
uniprot id: Q9TYP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE T05C3.8
gene id: 6239:CELE_T05C3.8
uniprot id: Q86B40
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE H34C03.1
gene id: 6239:CELE_H34C03.1
uniprot id: Q9TYY7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in embryos.
messages: In the first mitotic division in embryos, required for mitotic spindle alignment and asymmetric cell division (PubMed:9649522, PubMed:17947426). Required for motor-driven chromosome movement and homolog searching within the nucleus, and subsequently ensures homologous chromosome pairing during the prophase stage of meiosis (PubMed:23671424).
messages: Mitochondrion
messages: Mitochondrion outer membrane

6239:CELE F46B6.6
gene id: 6239:CELE_F46B6.6
uniprot id: Q20447
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

6239:CELE T22H2.6
gene id: 6239:CELE_T22H2.6
uniprot id: Q7JKP2
uniprot id: Q9U362
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

6239:CELE B0212.5
gene id: 6239:CELE_B0212.5
uniprot id: G5EBV8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y39B6A.47
gene id: 6239:CELE_Y39B6A.47
uniprot id: Q9NEV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F20B4.6
gene id: 6239:CELE_F20B4.6
uniprot id: G5EC84
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer). GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction (PubMed:11443131, PubMed:19240113, PubMed:21325339). Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085).
messages: Expressed mostly in intestine and vulva.
messages: Membrane
messages: Reduced brood size.
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

6239:CELE W06H3.2
gene id: 6239:CELE_W06H3.2
uniprot id: Q9XXN0
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

6239:CELE H25K10.1
gene id: 6239:CELE_H25K10.1
uniprot id: G5EE15
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

6239:CELE T14B4.3
gene id: 6239:CELE_T14B4.3
uniprot id: Q22482
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F37A4.7
gene id: 6239:CELE_F37A4.7
uniprot id: P41885
names: Function
names: Subcellular Location Annotation
messages: Rab-3 effector.
messages: Synapse

6239:CELE Y106G6H.5
gene id: 6239:CELE_Y106G6H.5
uniprot id: Q9U300
names: Similarity
messages: Belongs to the GcvT family.

6239:CELE C49A9.7
gene id: 6239:CELE_C49A9.7
uniprot id: O44148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE T24C12.2
gene id: 6239:CELE_T24C12.2
uniprot id: Q22720
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.

6239:CELE Y19D10A.15
gene id: 6239:CELE_Y19D10A.15
uniprot id: G5EFQ7
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y22F5A.4
gene id: 6239:CELE_Y22F5A.4
uniprot id: O62415
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: Cytoplasmic vesicle lumen
messages: Expressed in intestine, IL2 and IL6 neurons and some neurons in the head ganglia.
messages: Induced by Gram-negative bacteria S.marcescens and B.thuringiensis infection.
messages: Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection.
messages: Lacks conserved active site residues, suggesting it has no catalytic activity.
messages: RNAi-mediated knockdown causes a reduction in survival in response to bacterium S.aureus infection.

6239:CELE C34B4.2
gene id: 6239:CELE_C34B4.2
uniprot id: Q18419
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08H10.4
gene id: 6239:CELE_K08H10.4
uniprot id: Q9XU84
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDA1/CD39 NTPase family.
messages: By stress such as high temperature or ethanol.
messages: Endomembrane system
messages: Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum.

6239:CELE M117.3
gene id: 6239:CELE_M117.3
uniprot id: Q21539
names: Similarity
messages: Belongs to the 14-3-3 family.

6239:CELE R09B5.6
gene id: 6239:CELE_R09B5.6
uniprot id: O44608
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

6239:CELE H13N06.5
gene id: 6239:CELE_H13N06.5
uniprot id: Q9XTQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: Expressed in somatic tissues.
messages: Membrane
messages: Zinc transporter.

6239:CELE F30A10.5
gene id: 6239:CELE_F30A10.5
uniprot id: H2FLJ1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the band 7/mec-2 family.
messages: Induced by anoxia (PubMed:24385935). Induced by paraquat, a chemical causing production of reactive oxygen species (ROS) (PubMed:24385935).
messages: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria (By similarity). In neurons, involved in mitochondrial fusion and recovery of normal locomotory behavior during reoxygenation; probably acts independently of egl-9 and the canonical hypoxia response pathway (PubMed:24385935).
messages: Mitochondrion
messages: Widely expressed in most tissues, including body wall muscles, intestinal epithelia, and pharynx and head neurons.

6239:CELE R07B7.5
gene id: 6239:CELE_R07B7.5
uniprot id: Q21795
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Membrane
messages: Mitochondrion

6239:CELE C38C10.1
gene id: 6239:CELE_C38C10.1
uniprot id: Q03566
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE ZK783.4
gene id: 6239:CELE_ZK783.4
uniprot id: Q23590
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WAL family.
messages: Broadly expressed in the nervous system, including head, body and tail neurons.
messages: Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178). May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178). Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178). Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178). Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178). Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
messages: Chromosome
messages: Expression increases with age.
messages: Interacts with set-6.
messages: Nucleus
messages: RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

6239:CELE F33G12.3
gene id: 6239:CELE_F33G12.3
uniprot id: Q19987
names: Similarity
messages: Belongs to the UPF0415 family.

6239:CELE Y52E8A.4
gene id: 6239:CELE_Y52E8A.4
uniprot id: A0A0K3AR66
uniprot id: A0A0K3AUS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE Y37A1B.11
gene id: 6239:CELE_Y37A1B.11
uniprot id: A0A061AL62
uniprot id: C0Z3L1
uniprot id: Q9XXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE W04C9.6
gene id: 6239:CELE_W04C9.6
uniprot id: Q9TZE1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F40G9.2
gene id: 6239:CELE_F40G9.2
uniprot id: Q9TZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

6239:CELE Y59H11AM.1
gene id: 6239:CELE_Y59H11AM.1
uniprot id: Q95XU7
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y71F9B.10
gene id: 6239:CELE_Y71F9B.10
uniprot id: Q9N4G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F12F3.1
gene id: 6239:CELE_F12F3.1
uniprot id: H2KZQ7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C12D8.11
gene id: 6239:CELE_C12D8.11
uniprot id: Q27274
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm
messages: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs.
messages: The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
messages: The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).

6239:CELE Y43B11AR.4
gene id: 6239:CELE_Y43B11AR.4
uniprot id: Q9N3X2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

6239:CELE C50E10.8
gene id: 6239:CELE_C50E10.8
uniprot id: A3QMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F44E7.8
gene id: 6239:CELE_F44E7.8
uniprot id: J7SF93
uniprot id: Q8MXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE B0286.2
gene id: 6239:CELE_B0286.2
uniprot id: G5ECX0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: May have a role in pharyngeal pumping during feeding.
messages: Pharyngeal primordium.
messages: Reduced response to the inhibitory action of emodepside in pharyngeal pumping.

6239:CELE C13F10.2
gene id: 6239:CELE_C13F10.2
uniprot id: O01488
names: Similarity
messages: Belongs to the KXD1 family.

6239:CELE C01F1.6
gene id: 6239:CELE_C01F1.6
uniprot id: Q17555
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C33B4.3
gene id: 6239:CELE_C33B4.3
uniprot id: B7WN72
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are viable, but produce a reduced brood size, have a prolonged defecation cycle and a reduced pharyngeal pumping rate as compared to wild-type (PubMed:21191812). Reduced male fertility which may be due to irregular male mating behavior and defective sperm function (PubMed:21191812). Reduced cell surface abundance of the L-type egl-19 calcium channel in body wall muscles, which results in a 20% decrease in Ca(2+) current density (PubMed:28477407). In response to the nicotinic acetylcholine agonist levamisole, there is reduced expression of genes such as gem-4 (PubMed:28477407). Irregular postsynaptic transmission at neuromuscular junctions characterized by larger stimulus-evoked excitatory postsynaptic currents as compared to wild-type (PubMed:28477407). RNAi-mediated knockdown results in viable animals with no visible phenotype (PubMed:15013747). However, there is a slight reduction in brood size, but there are no visible defects in terms of embryonic viability, growth or morphology in their resulting progeny (PubMed:15013747). RNAi-mediated knockdown in an itr-1(sa73) loss of function mutant background results in a longer defecation cycle as compared to the itr-1 single mutant (PubMed:15013747).
messages: Belongs to the SHANK family.
messages: Cytoplasmic vesicle
messages: Expressed in the pharynx, pharyngeal-intestinal valve, intestine, rectal epithelial cells, tail neurons, nerve cord and sperm.
messages: Expressed throughout development from embryos to adults. Highly expressed in the nerve cord of embryos. Expressed in vulval epithelial cells of L4 stage hermaphrodites.
messages: In contrast to the mammalian Shank proteins, does not contain a SH3 domain.
messages: Interacts (via PDZ domain) with egl-19 (via C-terminus).
messages: Postsynaptic density
messages: Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions (PubMed:28477407). Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density (PubMed:28477407). The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4 (PubMed:28477407). Plays a role in the regulation of the defecation cycle, and this may be in association with the inositol trisphosphate (IP3) receptor itr-1, which in turn mediates periodic calcium release and muscle contractions (PubMed:15013747, PubMed:21191812). Required for normal fertility and pharyngeal pumping (PubMed:21191812).
messages: pseudopodium

6239:CELE F56A4.1
gene id: 6239:CELE_F56A4.1
uniprot id: Q966D9
uniprot id: Q9N5R0
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Metalloprotease.
messages: Secreted

6239:CELE F55D10.1
gene id: 6239:CELE_F55D10.1
uniprot id: Q20829
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE R03E9.4
gene id: 6239:CELE_R03E9.4
uniprot id: P52192
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Cell projection
messages: Expressed in neurons in the head and tail with no expression detected in non-neuronal cells in these regions. Also detected in the egg-laying system of adult hermaphordites with strong expression in the HSN motor neurons and weak expression in vulval muscles.
messages: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior.
messages: Membrane
messages: Perikaryon
messages: Strongly suppresses the egg-laying defect caused by a mutant form of egl-6. Very mild defect in egg-laying behavior when deleted in a wild-type background.

6239:CELE T04H1.5
gene id: 6239:CELE_T04H1.5
uniprot id: Q22178
names: Similarity
messages: Belongs to the GPATCH11 family.

6239:CELE F53F4.14
gene id: 6239:CELE_F53F4.14
uniprot id: G5EC45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE F17E9.1
gene id: 6239:CELE_F17E9.1
uniprot id: O61525
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE D1046.4
gene id: 6239:CELE_D1046.4
uniprot id: Q18935
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01G6.8
gene id: 6239:CELE_T01G6.8
uniprot id: O16963
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y39B6A.22
gene id: 6239:CELE_Y39B6A.22
uniprot id: Q8MYN7
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE F52C9.8
gene id: 6239:CELE_F52C9.8
uniprot id: Q10124
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the REXO1/REXO3 family.
messages: Expressed in the excretory canal, vulval cells, the intestine and in head and tail neurons including ASH, RIC and AIZ neurons.
messages: Nucleus
messages: Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins (PubMed:12486229). It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration (PubMed:12486229). Regulates gene expression in neurons (PubMed:22870397).
messages: The Gln/Pro-rich N-terminus and the Arg/Asp/Glu/Lys-rich charged domain are critical in protecting glutamatergic ASH sensory neurons from degeneration. ASH neurons expressing isoforms lacking these domains show progressive degeneration.

6239:CELE Y105C5B.19
gene id: 6239:CELE_Y105C5B.19
uniprot id: Q9NAM2
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE M01E11.6
gene id: 6239:CELE_M01E11.6
uniprot id: P91400
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE F58G11.1
gene id: 6239:CELE_F58G11.1
uniprot id: Q9XVL7
uniprot id: Q9XVM0
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE C27D6.10
gene id: 6239:CELE_C27D6.10
uniprot id: Q95ZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE D2005.6
gene id: 6239:CELE_D2005.6
uniprot id: Q93411
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H36L18.1
gene id: 6239:CELE_H36L18.1
uniprot id: O17913
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

6239:CELE ZK643.2
gene id: 6239:CELE_ZK643.2
uniprot id: P30648
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Supplies the nucleotide substrate for thymidylate synthetase.

6239:CELE Y22D7AL.14
gene id: 6239:CELE_Y22D7AL.14
uniprot id: Q965P2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

6239:CELE ZK652.6
gene id: 6239:CELE_ZK652.6
uniprot id: P34664
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F32H2.1
gene id: 6239:CELE_F32H2.1
uniprot id: P91868
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs.
messages: Broadly expressed in all tissues, including head, vulva and tail.
messages: Expressed throughout development.
messages: Nucleus
messages: RNAi-mediated knockdown from larval stage L1 results in decreased 21U-RNA expression and disrupted distribution of prde-1 foci within the nuclei of germ cells.

6239:CELE K12H6.1
gene id: 6239:CELE_K12H6.1
uniprot id: G4SCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C07A9.4
gene id: 6239:CELE_C07A9.4
uniprot id: P34315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

6239:CELE R06B9.2
gene id: 6239:CELE_R06B9.2
uniprot id: A0A131MBN2
uniprot id: A0A131MCQ1
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE ZC334.9
gene id: 6239:CELE_ZC334.9
uniprot id: Q7JKM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE JC8.7
gene id: 6239:CELE_JC8.7
uniprot id: D3YT79
uniprot id: O62291
names: Similarity
messages: Belongs to the HPF1 family.

6239:CELE F07A5.3
gene id: 6239:CELE_F07A5.3
uniprot id: Q19140
names: Similarity
messages: Belongs to the CD36 family.

6239:CELE Y57A10C.3
gene id: 6239:CELE_Y57A10C.3
uniprot id: O62488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F42A6.6
gene id: 6239:CELE_F42A6.6
uniprot id: K8ERU5
uniprot id: K8FDZ3
uniprot id: L8E808
uniprot id: U4PBW7
names: Similarity
messages: Belongs to the OPI10 family.

6239:CELE Y22D7AL.8
gene id: 6239:CELE_Y22D7AL.8
uniprot id: A0A1C3NSJ8
uniprot id: A0A1C3NSJ9
uniprot id: A0A1C3NSK5
uniprot id: A0A1C3NSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

6239:CELE B0213.11
gene id: 6239:CELE_B0213.11
uniprot id: A0A164D3C9
uniprot id: O44656
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE ZK131.8
gene id: 6239:CELE_ZK131.8
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y46G5A.21
gene id: 6239:CELE_Y46G5A.21
uniprot id: G5EFP8
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

6239:CELE C09D1.1
gene id: 6239:CELE_C09D1.1
uniprot id: O01761
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Expressed in body-wall, pharyngeal muscles and a few muscle cells of the tail (at protein level) (PubMed:8603916, PubMed:18337465, PubMed:19244614, PubMed:22621901, PubMed:22768340, PubMed:23283987, PubMed:27009202). Expressed in gonadal myoepithelial sheath cells (at protein level) (PubMed:17326220). Isoform c: Expressed in body wall and vulval muscles but not in pharyngeal muscles (PubMed:15313609). Isoform d: Specifically expressed in vulval, intestinal, anal depressor and anal sphincter muscles (PubMed:15313609).
messages: Expressed in embryos (PubMed:23283987). Isoform a: Expressed in embryo, throughout larval development and in adults (PubMed:15313609). Isoform b: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform c: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform d: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
messages: In contrast to obscurins in other species, unlikely to have serine/threonine kinase activity as both protein kinase domains are predicted to be catalytically inactive. The Lys residue involved in ATP binding is not conserved in both kinase domains.
messages: M line
messages: May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or C-terminus of the interkinase region) with lim-9 (via LIM zinc-binding domain) (PubMed:19244614). May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614). May interact (via SH3 domain) with unc-15 (PubMed:27009202). May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987). May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901). May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).
messages: Mutants lacking isoform a, isoform b, isoform e and isoform f have an abnormal organization of the myofilament lattice of body wall and pharyngeal muscles (PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:27009202). In body wall muscles, unc-15/paramyosin accumulates in large foci outside thick filaments and myosin heavy chains unc-54 and myo-3 fail to assemble into parallel myofibrils (PubMed:27009202). In addition, myosin thick filaments are disorganized with the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A bands (PubMed:18801371, PubMed:22621901). In mutants lacking isoform b, isoform c, isoform d and isoform f, myo-3 fails to assemble into parallel myofibrils whereas unc-54 and unc-15 localization is normal (PubMed:27009202). Mutants lacking isoform b, isoform c, isoform d and isoform f have defects only in body wall muscle structure (PubMed:16453163). RNAi-mediated knockdown of isoform a or isoform b, isoform c and isoform d causes similar defects in the organization although RNAi-mediated knockdown of isoform c causes a less severe defect in myofilament organization (PubMed:15313609). In mutants lacking isoform a, isoform b, isoform e and isoform f, mei-1 protein levels are decreased by 20 percent (PubMed:22621901). RNAi-mediated knockdown of isoform a, isoform b, isoform e and isoform f but not of isoforms c and d disrupts sca-1 localization to linear punctate structures along in the M line in body wall muscles (PubMed:22768340). RNAi-mediated knockdown has no effect on ovulation (PubMed:17326220).
messages: Protein kinase domains 1 and 2 are predicted to be catalytically inactive (PubMed:16453163). The two kinase domains are required for the organization of thick filament component myosin heavy chain myo-3 but not of myosin heavy chain unc-54 and unc-15/paramyosin (PubMed:27009202).
messages: Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments (PubMed:15313609, PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:23283987, PubMed:27009202). The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340). Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202). By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901). Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371). The large isoforms regulate Ca(2+) signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca(2+) ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340). By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609).
messages: The PH domain does not bind inositol 1,4,5-trisphosphate. The PH domain has an unusual closed conformation of the lipid binding site which is lined by negative charged amino acids which probably prevents binding to membrane lipids.
messages: The SH3 domain is required for the organization of thick filament components myosin heavy chain unc-54 and myo-3 and unc-15/paramyosin.

6239:CELE K10D3.1
gene id: 6239:CELE_K10D3.1
uniprot id: Q21415
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abolishes signal transduction during cold signaling in intestine and ASER neuron.
messages: Activated by low temperature of 18 degrees Celsius in ASER neuron.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: During embryogenesis, expressed just before hatching at low levels.
messages: Expressed in the intestine and in the ASER neuron (PubMed:31474366). Also expressed in the thermosensitive RIA interneuron (PubMed:11222641).
messages: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor in the ASER neuron where it triggers a calcium response to activate cold avoidance behavior in response to temperatures below 19 degrees Celsius (PubMed:31474366). Possibly functions as a metabotropic cold receptor and acts upstream of the G(o) G protein goa-1 in the ASER neuron (PubMed:31474366). Also functions in cold sensing in the intestine (PubMed:31474366).
messages: Ionotropic glutamate receptor (By similarity). Activation by glutamate requires additional verification (PubMed:31474366). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity).
messages: Postsynaptic cell membrane

6239:CELE ZK1128.1
gene id: 6239:CELE_ZK1128.1
uniprot id: Q09644
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

6239:CELE F15A4.1
gene id: 6239:CELE_F15A4.1
uniprot id: O17816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F23C8.7
gene id: 6239:CELE_F23C8.7
uniprot id: Q9TXI2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y116A8C.27
gene id: 6239:CELE_Y116A8C.27
uniprot id: Q9U2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

6239:CELE F19H6.4
gene id: 6239:CELE_F19H6.4
uniprot id: Q19605
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

6239:CELE K11H3.1
gene id: 6239:CELE_K11H3.1
uniprot id: A7LPE5
uniprot id: A7LPE6
uniprot id: P34517
uniprot id: Q7JMU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homodimer.

6239:CELE F42G2.5
gene id: 6239:CELE_F42G2.5
uniprot id: O17099
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y10G11A.2
gene id: 6239:CELE_Y10G11A.2
uniprot id: A0AAC1
uniprot id: Q8MPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6239:CELE ZK836.2
gene id: 6239:CELE_ZK836.2
uniprot id: F5GUD7
uniprot id: Q23629
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Mitochondrion
messages: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

6239:CELE T06D10.1
gene id: 6239:CELE_T06D10.1
uniprot id: Q9U379
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

6239:CELE C27B7.4
gene id: 6239:CELE_C27B7.4
uniprot id: Q18241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

6239:CELE F57G9.1
gene id: 6239:CELE_F57G9.1
uniprot id: O62266
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T25G3.3
gene id: 6239:CELE_T25G3.3
uniprot id: Q22792
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE C05D9.1
gene id: 6239:CELE_C05D9.1
uniprot id: Q9GYJ9
names: Similarity
messages: Belongs to the sorting nexin family.

6239:CELE Y69H2.3
gene id: 6239:CELE_Y69H2.3
uniprot id: A8WI97
uniprot id: L8E6L7
uniprot id: L8E811
uniprot id: L8EC36
uniprot id: Q8I4B8
uniprot id: Q8I4B9
uniprot id: Q9U1T5
uniprot id: Q9U1T6
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F29G6.2
gene id: 6239:CELE_F29G6.2
uniprot id: Q93635
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCDC149 family.
messages: Expressed in amphid and phasmid ciliated neurons, and also pharyngeal, touch receptor and motor neurons.
messages: cilium

6239:CELE F13E9.13
gene id: 6239:CELE_F13E9.13
uniprot id: Q1NZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BtpA family.
messages: Mitochondrion

6239:CELE T12C9.7
gene id: 6239:CELE_T12C9.7
uniprot id: A9Z1K4
uniprot id: H2L0L4
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE F44C8.5
gene id: 6239:CELE_F44C8.5
uniprot id: H2L017
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F52E10.1
gene id: 6239:CELE_F52E10.1
uniprot id: P24349
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Component of the SDC complex, which consists of sdc-1, sdc-2 and sdc-3. Within the complex, interacts with sdc-2 and sdc-3.
messages: Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes (PubMed:2027384). Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:11937488). Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:11937488). Similarly, might contribute to X-linked gene repression through recruitment of the dosage compensation complex to the X chromosomes in hermaphrodites (PubMed:11937488). Seems to be involved in the depletion of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes (PubMed:22393255). Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2 pathway (PubMed:23884442).
messages: In the TOR complex 2 mutant background rict-1, RNAi-mediated knockdown suppresses the growth delay and elevated body fat index.
messages: Nucleus

6239:CELE F18E9.5
gene id: 6239:CELE_F18E9.5
uniprot id: Q95QK3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the UTX family.
messages: Expressed in the Y cell before transdifferentiation in the embryo and during redifferentiation into the PDA neuron in larval stages L2 and L3 but not in larval stage L1 (PubMed:25124442). Expression declines in the adult soma (PubMed:26212459).
messages: Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code (PubMed:17713478, PubMed:25124442). Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes (PubMed:26212459, PubMed:27133168). Required for gonad development and organization (PubMed:17713478). Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development (PubMed:25124442). Acts cell-autonomously in Y-to-PDA transdifferentiation, which depends on the demethylase activity and on recognition of the H3 tail (PubMed:25124442). Cooperates with set-2 and unc-3 to ensure robust Y-to-PDA transdifferentiation (PubMed:25124442). Promotes mitochondrial stress-induced longevity (PubMed:27133168). Involved in lifespan regulation (PubMed:21803287, PubMed:26212459).
messages: Interacts with wdr-5.1 and unc-3.
messages: Mainly expressed in head and tail.
messages: Nucleus
messages: RNAi-mediated knockdown results in abnormal gonad migration with aberrant turns and positioning of the distal end as well as in disorganized accumulation of oocytes in the proximal gonad arm (PubMed:17713478). RNAi-mediated knockdown also results in disruption of invariant Y-to-PDA transdifferentiation (PubMed:25124442). RNAi-mediated knockdown suppresses mitochondrial stress response mediated longevity (PubMed:27133168). RNAi-mediated knockdown reduces lifespan of floxuridine-treated animals (PubMed:21803287).

6239:CELE ZC84.2
gene id: 6239:CELE_ZC84.2
uniprot id: Q03611
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
messages: Expressed at the sensory endings of thermosensory, gustatory, and olfactory neurons.
messages: Membrane
messages: Required for normal thermosensation and chemosensation sensory behavior (PubMed:8893027). Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons (PubMed:21173231). Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons (PubMed:23664973). Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation (PubMed:9486798). Required for the calcium flux to the cytoplasm in the ASJ sensory neurons upon the onset and removal of a nitric oxide (NO) stimulus, thereby promoting the ASJ-mediated behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846). In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:25303524). In AWB and AWC sensory neurons, mediates the recognition of food odors which subsequently allows for the detection of preferred food sources (PubMed:25009271). In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family.
messages: cilium

6239:CELE Y48B6A.11
gene id: 6239:CELE_Y48B6A.11
uniprot id: Q9U297
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:24685137). Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion (PubMed:22212395).
messages: Increased H3 'Lys-9' and 'Lys-36' trimethylation levels on meiotic chromosomes leading to trigger p53-dependent germline apoptosis (PubMed:16603238). In spr-5 null mutants, suppresses the progressive sterility over generations which is seen in spr-5 mutants (PubMed:24685137). RNAi-mediated knockdown results in extended lifespan (PubMed:22212395).
messages: Nucleus

6239:CELE K07C6.2
gene id: 6239:CELE_K07C6.2
uniprot id: O44652
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F52H2.2
gene id: 6239:CELE_F52H2.2
uniprot id: A0A0K3AVL7
uniprot id: O17395
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F48C11.1
gene id: 6239:CELE_F48C11.1
uniprot id: Q93743
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE K05C4.7
gene id: 6239:CELE_K05C4.7
uniprot id: Q9XUU5
names: Function
names: Subcellular Location Annotation
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

6239:CELE F13G3.5
gene id: 6239:CELE_F13G3.5
uniprot id: Q19420
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
messages: Isoform 1 is strongly expressed in the AFD and RIA neurons of the head, in the tail and in coelomocytes. Isoform 1 is weakly expressed in nerve cord motor neurons, intestine, and the somatic gonad.
messages: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for thermotaxis.
messages: Worms lacking ttx-7 display defects in thermotaxis behavior and localization of synaptic proteins in RIA neurons yet appear morphologically normal.

6239:CELE Y19D2B.1
gene id: 6239:CELE_Y19D2B.1
uniprot id: Q9XXH2
names: Similarity
messages: Belongs to the tubulin family.

6239:CELE Y110A7A.4
gene id: 6239:CELE_Y110A7A.4
uniprot id: Q9N588
names: Similarity
messages: Belongs to the thymidylate synthase family.

6239:CELE Y5H2B.5
gene id: 6239:CELE_Y5H2B.5
uniprot id: Q9N4Q5
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F13G3.9
gene id: 6239:CELE_F13G3.9
uniprot id: P90835
names: Similarity
messages: Belongs to the MIF family.

6239:CELE T09D3.1
gene id: 6239:CELE_T09D3.1
uniprot id: Q9GS01
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE K01A6.6
gene id: 6239:CELE_K01A6.6
uniprot id: H9G2T5
uniprot id: Q21077
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y105E8A.1
gene id: 6239:CELE_Y105E8A.1
uniprot id: K8ES47
uniprot id: Q9NF23
names: Similarity
messages: Belongs to the SH3BGR family.

6239:CELE F54C9.2
gene id: 6239:CELE_F54C9.2
uniprot id: Q20752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

6239:CELE C18E3.8
gene id: 6239:CELE_C18E3.8
uniprot id: O02100
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Down-regulated by spr-1, spr-3, spr-4 and spr-5.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Predominantly expressed in the adult. Weakly expressed in the embryo, L2 and L3 stages, and almost absent in L1 stage larvae.
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable).
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.
messages: The PAL motif is required for normal active site conformation.
messages: Weakly expressed.

6239:CELE Y24D9A.1
gene id: 6239:CELE_Y24D9A.1
uniprot id: A0A0K3ARM3
names: Similarity
messages: Belongs to the ELL/occludin family.

6239:CELE T20F7.3
gene id: 6239:CELE_T20F7.3
uniprot id: O02167
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

6239:CELE T09A5.12
gene id: 6239:CELE_T09A5.12
uniprot id: P45972
names: Disruption Phenotype
names: Function
messages: Probable transcription factor (PubMed:24885717). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717).
messages: RNAi-mediated knockdown reduces expression of homeobox protein lin-39 in vulval precursor cells at the larval L3 stage.

6239:CELE B0041.6
gene id: 6239:CELE_B0041.6
uniprot id: O02058
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Homohexamer formed of two homotrimers in a head to head fashion.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity).
messages: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.

6239:CELE Y66D12A.17
gene id: 6239:CELE_Y66D12A.17
uniprot id: Q95Q00
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the APC5 family.
messages: Double RNAi-mediated knockdown and/or mutagenesis with gfi-3 results in increased embryonic lethality and the production of one-cell arrested embryos.
messages: Expressed in head neurons, vulval precursor cells and in mature sperm stored in the spermatheca.
messages: Expressed in the developing germ line and throughout embryogenesis.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis (PubMed:17237515, PubMed:20944012). Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells (PubMed:20944014).
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE T13C2.4
gene id: 6239:CELE_T13C2.4
uniprot id: Q22453
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SSU72 phosphatase family.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in epidermis, intestine and nervous system.
messages: May be phosphorylated by kin-20.
messages: May interact with synd-1 (via C-terminus); the interaction may prevent ssup-72 binding to RNA polymerase II ama-1 (PubMed:26588990). May interact with RNA polymerase II ama-1 (Probable).
messages: Nucleus
messages: Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1 (PubMed:26588990). By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre-mRNAs, including unc-44 and dlk-1 mRNAs (PubMed:26588990, PubMed:28087624). This results in the tissue-specific expression of unc-44 isoforms (PubMed:28087624).

6239:CELE ZC410.2
gene id: 6239:CELE_ZC410.2
uniprot id: Q23295
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binding to mppa-1 is required for catalytic activity (PubMed:16788047). Inhibited by metal chelator ethylenediaminetetraacetic acid (EDTA) (PubMed:16788047).
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (Probable).
messages: Heterodimer of mppa-1 (alpha) and mppb-1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which mppa-1 is involved in substrate recognition and binding and mppb-1 is the catalytic subunit.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown causes 54 percent embryonic lethality (PubMed:16788047). Embryonic lethality is further increased in simultaneous RNAi-mediated knockdown of mmpa-1 and mmpb-1 or ucr-1 and mppb-1 (PubMed:16788047).

6239:CELE F46E10.10
gene id: 6239:CELE_F46E10.10
uniprot id: Q9UAV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible conversion of (S)-malate to oxaloacetate in the cytoplasm where oxaloacetate is used for gluconeogenesis.
messages: Cytoplasm
messages: Homodimer.

6239:CELE T03F1.3
gene id: 6239:CELE_T03F1.3
uniprot id: P91427
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

6239:CELE C45E5.1
gene id: 6239:CELE_C45E5.1
uniprot id: Q18645
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

6239:CELE F23F12.9
gene id: 6239:CELE_F23F12.9
uniprot id: P46505
names: Similarity
messages: Belongs to the bZIP family.

6239:CELE F33A8.6
gene id: 6239:CELE_F33A8.6
uniprot id: G5EDI3
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE T05A12.2
gene id: 6239:CELE_T05A12.2
uniprot id: Q7K866
uniprot id: Q9GYK9
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

6239:CELE ZK380.1
gene id: 6239:CELE_ZK380.1
uniprot id: O61764
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08H10.9
gene id: 6239:CELE_K08H10.9
uniprot id: Q9XU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

6239:CELE T19H12.2
gene id: 6239:CELE_T19H12.2
uniprot id: O01615
names: Similarity
messages: Belongs to the ANP32 family.

6239:CELE R07B7.1
gene id: 6239:CELE_R07B7.1
uniprot id: G5EC75
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE T10B11.1
gene id: 6239:CELE_T10B11.1
uniprot id: Q9TZH6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

6239:CELE F53A9.4
gene id: 6239:CELE_F53A9.4
uniprot id: Q20687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

6239:CELE T18H9.6
gene id: 6239:CELE_T18H9.6
uniprot id: Q22550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 27 family.
messages: Nucleus

6239:CELE K07A1.10
gene id: 6239:CELE_K07A1.10
uniprot id: P90915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

6239:CELE F02E9.2
gene id: 6239:CELE_F02E9.2
uniprot id: P92186
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cleavage by caspase ced-3 during larval development probably induces lin-28 degradation.
messages: Component of a complex at least containing lep-2, lin-28 and the long non-coding RNA lep-5, which mediates the degradation of lin-28.
messages: Cytoplasm
messages: Expressed at the first larval stage (L1) in several cell types including hypodermis, muscle, neurons and seam cells (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153). Also expressed in the tail tip and pharynx at the L1 stage (PubMed:26811380). Down-regulated at L2, and absent from L3 and L4 (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153).
messages: Heterochronic protein which controls the choice of stage specific cell fates (PubMed:9054503, PubMed:6494891, PubMed:2702689, PubMed:2628162, PubMed:1916265, PubMed:7671811, PubMed:8625405, PubMed:8756295, PubMed:8756296, PubMed:9477318, PubMed:9649524, PubMed:10706289, PubMed:12871707, PubMed:15073154, PubMed:16139228). Regulates the timing of the second larval stage events (L2 events) in the hypodermis (PubMed:2702689, PubMed:2628162). May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (PubMed:10706289, PubMed:12871707, PubMed:16139228). Through this regulatory role, controls the timing of the sexual maturation of the nervous system (PubMed:31264582). Also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153). Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008). Plays a role in controlling the seam cell number during larval stages (PubMed:21471153, PubMed:28602583). Plays a role in vulval development (PubMed:28602583).
messages: Negatively regulated by the miRNA lin-4 which causes degradation of the mRNA encoding this protein. This requires a lin-4 complementary element (LCE) in the 3'-UTR of the mRNA encoding this protein. Also negatively regulated independent of lin-4 and this is counteracted by the action of lin-14. Positively regulated by TGF-beta signaling.
messages: RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including impaired egg-laying and production of ectopic seam cells. RNAi-mediated knockdown results in the precocious onset of tail tip retraction at the L3 larval stage resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown suppresses the male tail tip morphogenesis defects of mutants for the long non-coding RNA lep-5 (PubMed:30956008).

6239:CELE D2085.4
gene id: 6239:CELE_D2085.4
uniprot id: O17736
names: Disruption Phenotype
names: Function
names: Subunit
messages: E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos.
messages: Interacts with ify-1 and cyb-1.
messages: RNAi-mediated knockdown causes a reduction in progeny viability. ify-1 and cyb-1 accumulate in the cytoplasm during meiosis II. Also extents the length of meiosis II and causes retention of rec-8, a component of the cohesin complex, at sister chromatid cohesion. Causes a delay in oocyte budding.

6239:CELE M01H9.2
gene id: 6239:CELE_M01H9.2
uniprot id: Q95018
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y69A2AL.2
gene id: 6239:CELE_Y69A2AL.2
uniprot id: Q3V5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

6239:CELE F56H9.8
gene id: 6239:CELE_F56H9.8
uniprot id: C4ALD6
uniprot id: G3MU17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C07H4.2
gene id: 6239:CELE_C07H4.2
uniprot id: G5EGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

6239:CELE Y39B6A.20
gene id: 6239:CELE_Y39B6A.20
uniprot id: G5EEI4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartic protease, which is part of the necrosis cell death pathway (PubMed:26795495, PubMed:12410314). Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells (PubMed:26795495). Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis (PubMed:26795495).
messages: Belongs to the peptidase A1 family.
messages: Cytoplasm
messages: Expression begins at the 2-fold embryonic stage and continues throughout the larval stages (at protein level) (PubMed:10854422). During the early stages of larval development, specifically expressed in the intestinal cells with the highest levels in the posterior intestinal cells int7 and int8 (PubMed:10854422). Not expressed in adults (PubMed:10854422).
messages: Interacts with B.thuringiensis endotoxin Cry6Aa; the interaction prevents Cry6Aa proteolysis by host gut proteases.
messages: Lysosome
messages: RNAi-mediated knockdown partially prevents neuronal degeneration in a mec-4(u231), deg-1(u38) or gsa-1(Q227L) gain-of-function mutant background.
messages: Secreted
messages: Up-regulated by B.thuringiensis endotoxin Cry6Aa (at protein level).

6239:CELE T19A5.2
gene id: 6239:CELE_T19A5.2
uniprot id: H2L099
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Interacts (via N-terminus) with mpk-1 (isoform a) (PubMed:19826475). Interacts with ccm-3 (PubMed:25743393).
messages: RNAi-mediated knockdown causes sterility resulting from several defects in oogenesis. Proximal ends of the gonads are filled with small germ cells and have a decrease in the number of nuclei in all stages of oogenesis especially at the pachytene stage where there is 60 percent less nuclei. In addition, animals lack a discernible rachis which is a tube-like formation of anucleate cytoplasm between pachytene nuclei, no clear transition into progression from pachytene to diplotene stage and a failure to progress from diplotene into diakinesis. Increased germline cell apoptosis (PubMed:19826475). RNAi-mediated knockdown causes truncated excretory canals associated with the formation of cysts, a reduced distribution of Golgi and ER components along the excretory canals and a decrease in cdc-42 activation (PubMed:25743393).
messages: Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage (PubMed:19826475). Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 (PubMed:25743393).

6239:CELE C27C12.5
gene id: 6239:CELE_C27C12.5
uniprot id: G3MU02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F59A1.10
gene id: 6239:CELE_F59A1.10
uniprot id: Q9XUW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T15B7.11
gene id: 6239:CELE_T15B7.11
uniprot id: A0A131MBP5
uniprot id: A0A131MBW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K08D12.5
gene id: 6239:CELE_K08D12.5
uniprot id: D3KZG1
uniprot id: H2L0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE H34P18.1
gene id: 6239:CELE_H34P18.1
uniprot id: O76666
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE W03G9.4
gene id: 6239:CELE_W03G9.4
uniprot id: O44750
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11606206, PubMed:25905034). Has activity towards the flp-9 neuropeptide KPSFVRF-amide (PubMed:11606206).
messages: Cytoplasm
messages: Expressed in intestine from larval stage L2 onwards. Not detected in embryos.
messages: Homodimer (PubMed:25905034). May interact with pid-2, pid-4 and pid-5 (PubMed:33231880).
messages: Specifically expressed in the intestine.
messages: Strongly inhibited by the metal ion chelators EDTA and 1,10-phenanthroline (PubMed:11606206). Also inhibited by apstatin (PubMed:11606206, PubMed:25905034). Activity towards bradykinin is inhibited by Mn(2+) and Zn(2+) at all concentrations tested, whereas Co(2+) is inhibitory at concentrations above 100 uM and activatory at 10 uM (PubMed:11606206).

6239:CELE T14E8.4
gene id: 6239:CELE_T14E8.4
uniprot id: Q5WRS0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: (Microbial infection) Promotes infection by microsporidian pathogens such as N.parisii in the early larval stages of development (PubMed:34994689). Involved in ensuring the proper orientation and location of the spore proteins of N.parisii during intestinal cell invasion (PubMed:34994689).
messages: Expressed in the terminal bulb of the pharynx and the posterior of the intestine (at protein level) (PubMed:34994689). Expressed by intestinal cells and secreted into the intestinal lumen (at protein level) (PubMed:34994689).
messages: Expressed in the terminal bulb of the pharynx and the posterior of the intestine throughout development (at protein level) (PubMed:34994689). Expressed in the arcade cells of the pharynx in embryos and in L1 stage larvae (at protein level) (PubMed:34994689).
messages: Plays a role in promoting resistance to bacterial pathogens such as P.aeruginosa by inhibiting bacterial intestinal colonization.
messages: Resistant to infection by the microsporidian pathogen N.parisii and displays a fitness advantage phenotype, whereby there is increased fitness following infection by N.parisii (PubMed:34994689). Fewer invading N.parisii spores following infection at the L1 larval stage of development due to impaired orientation, location and angle of N.parisii spore proteins relative to the host's intestinal apical membrane (PubMed:34994689). Does not affect the ability of N.parisii to invade intestinal cells or N.parisii spore consumption by intestinal cells of L1 stage larvae (PubMed:34994689). Animals are not resistant to infection by N.parisii at the L3 larval stage of development (PubMed:34994689). Reduced survival following infection by the bacteria P.aeruginosa at the L1 and L4 larval stages due to increased accumulation of the bacteria within the intestinal lumen (PubMed:34994689). Reduced survival and increased numbers of N.parisii spore proteins following co-infection with N.parisii and P.aeruginosa (PubMed:34994689).
messages: Secreted
messages: Up-regulated following infection by the microsporidian pathogen N.parisii or the bacterial pathogen P.aeruginosa.

6239:CELE R03D7.7
gene id: 6239:CELE_R03D7.7
uniprot id: Q09597
names: Similarity
messages: Belongs to the nanos family.

6239:CELE Y38C1BA.3
gene id: 6239:CELE_Y38C1BA.3
uniprot id: Q9N527
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F02A9.2
gene id: 6239:CELE_F02A9.2
uniprot id: P34382
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Probably binds lipids.
messages: Secreted

6239:CELE Y65B4A.1
gene id: 6239:CELE_Y65B4A.1
uniprot id: Q9BL57
names: Similarity
messages: Belongs to the HTATSF1 family.

6239:CELE F25B4.1
gene id: 6239:CELE_F25B4.1
uniprot id: Q22968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE Y56A3A.1
gene id: 6239:CELE_Y56A3A.1
uniprot id: G5EFX8
uniprot id: Q0PDJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE K09D9.2
gene id: 6239:CELE_K09D9.2
uniprot id: Q9N5I1
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE W06B4.2
gene id: 6239:CELE_W06B4.2
uniprot id: Q23195
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

6239:CELE F54C1.3
gene id: 6239:CELE_F54C1.3
uniprot id: Q10665
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230). PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells.
messages: Expressed maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, mainly in Z2 and Z3 cells.
messages: Forms a heterotrimeric complex with the Polycomb proteins mes-2 and mes-3. Does not interact with mes-4. Interacts with nyfa-1 (PubMed:17574230).
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells.
messages: Nucleus
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230).
messages: Repressed by GLD-1, which associates with the 3'-UTR of the mRNA and prevents its translation.

6239:CELE B0024.15
gene id: 6239:CELE_B0024.15
uniprot id: Q8MQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE T08G2.3
gene id: 6239:CELE_T08G2.3
uniprot id: Q22347
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: By serotonin.
messages: Expressed in the epidermis and intestine.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: This enzyme is specific for acyl chain lengths of 4 to 16.

6239:CELE F45G2.9
gene id: 6239:CELE_F45G2.9
uniprot id: O62251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 808 (Um808) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

6239:CELE Y41D4B.19
gene id: 6239:CELE_Y41D4B.19
uniprot id: M1Z882
names: Subcellular Location Annotation
messages: nuclear pore complex

6239:CELE F59D8.2
gene id: 6239:CELE_F59D8.2
uniprot id: P18947
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the intestine of adult hermaphrodites.
messages: High sequence similarity with other vitellogenin genes means that assigning functions to individual proteins is difficult; authors sometimes refer to VITs or vitellogenins.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). Together with other vitellogenins, may play a role in modulating life-span, acting via induction of autophagy and lysosomal lipolysis (PubMed:26671266).
messages: Secreted
messages: Simultaneous RNAi-mediated knockdown of vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life span, causes accumulation of neutral lipid and an increase in lgg-1 foci in the proximal intestine; however, does not affect fertility or pharyngeal pumping rates (PubMed:26671266). Expression of transcription factors pha-4 and daf-16 are increased (PubMed:26671266).

6239:CELE C15H11.7
gene id: 6239:CELE_C15H11.7
uniprot id: O17586
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE T06A1.5
gene id: 6239:CELE_T06A1.5
uniprot id: O61929
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE D2092.2
gene id: 6239:CELE_D2092.2
uniprot id: P91198
names: Similarity
messages: Belongs to the PPP4R2 family.

6239:CELE F54D10.8
gene id: 6239:CELE_F54D10.8
uniprot id: Q9TZ82
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F54E12.5
gene id: 6239:CELE_F54E12.5
uniprot id: J7S164
uniprot id: J7SA65
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y71H2AM.3
gene id: 6239:CELE_Y71H2AM.3
uniprot id: Q2AAC0
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

6239:CELE M04G12.2
gene id: 6239:CELE_M04G12.2
uniprot id: P92005
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F44D12.4
gene id: 6239:CELE_F44D12.4
uniprot id: Q20393
names: Similarity
messages: Belongs to the GIPC family.

6239:CELE C08D8.1
gene id: 6239:CELE_C08D8.1
uniprot id: Q17824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE F37D6.6
gene id: 6239:CELE_F37D6.6
uniprot id: G5EDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

6239:CELE ZK809.3
gene id: 6239:CELE_ZK809.3
uniprot id: Q23597
names: Similarity
messages: Belongs to the complex I NDUFB6 subunit family.

6239:CELE F22D6.5
gene id: 6239:CELE_F22D6.5
uniprot id: Q19727
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

6239:CELE F39D8.4
gene id: 6239:CELE_F39D8.4
uniprot id: Q20191
names: Cofactor
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Deletion of several nucleotides that changes the frame.
messages: Metalloprotease.
messages: Secreted

6239:CELE F27D9.6
gene id: 6239:CELE_F27D9.6
uniprot id: Q19843
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F23B12.4
gene id: 6239:CELE_F23B12.4
uniprot id: A8WHS3
uniprot id: Q19751
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F59G1.5
gene id: 6239:CELE_F59G1.5
uniprot id: G5EC24
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm
messages: Expressed in embryonic cells, developing vulva, body wall muscles, head neurons and gonadal sheath cells.
messages: Involved in embryonic and larval development (PubMed:9472025, PubMed:20380830). Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP) (PubMed:9472025, PubMed:20380830). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15 (PubMed:16495308). Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1 (PubMed:11689700). Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23 (PubMed:9472025, PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100).
messages: RNAi-mediated knockdown causes an increase in ectopic formation of membrane extensions from body wall muscles and a reduction in life span caused by early stage mortality (PubMed:16495308, PubMed:16547100). Prevents constitutive dauer formation in a daf-2 e1370 mutant background (PubMed:16547100).

6239:CELE T07A5.6
gene id: 6239:CELE_T07A5.6
uniprot id: A7LPF8
uniprot id: G5EDQ5
uniprot id: Q9U377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

6239:CELE F47A4.3
gene id: 6239:CELE_F47A4.3
uniprot id: Q20498
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Expressed in all life stages with high expression in L1-L4 larvae stages.
messages: Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells.
messages: Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42.

6239:CELE F58B4.1
gene id: 6239:CELE_F58B4.1
uniprot id: Q7JLI1
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in excretory cell and in amphid and phasmid sheath glia.
messages: Metalloprotease.
messages: Secreted

6239:CELE F21A3.5
gene id: 6239:CELE_F21A3.5
uniprot id: O17828
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Chromosome
messages: Expressed in male and female germ cells.
messages: Nuclear factor required for the production of piwi-interacting RNA (piRNA) precursors (PubMed:24696457). Specifically required for piRNAs produced from loci associated with the Ruby motif (PubMed:24696457). Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters (PubMed:25373775). Required for normal fertility (PubMed:24696457).
messages: Nucleus

6239:CELE ZK1025.4
gene id: 6239:CELE_ZK1025.4
uniprot id: Q18LB5
uniprot id: Q9XXL9
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F46F6.2
gene id: 6239:CELE_F46F6.2
uniprot id: G5EFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

6239:CELE M03C11.4
gene id: 6239:CELE_M03C11.4
uniprot id: Q21484
names: Similarity
messages: Belongs to the HAT1 family.

6239:CELE F46A8.10
gene id: 6239:CELE_F46A8.10
uniprot id: Q9XV36
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE B0025.1
gene id: 6239:CELE_B0025.1
uniprot id: Q9TXI7
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family.
messages: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PubMed:11927551). Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking (PubMed:11927551, PubMed:16111945). Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797). Involved in clearance of apoptotic cell corpses by phagosomes (PubMed:22272187). Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7, downstream of dynamin dyn-1 (PubMed:22272187, PubMed:18425118). The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse (PubMed:22272187). Required for embryonic development (PubMed:22272187). Together with bec-1, involved in L3/L4 larval molting stage probably by regulating cuticle shedding (PubMed:11927551). Regulates the expansion of the nucleus outer membrane (PubMed:11927551). Involved in the secretion and localization of lrp-1 at the apical surface of hyp7 syncytium (PubMed:16111945). May regulate endocytosis in hypodermal cells (PubMed:11927551). May play a role in the formation of gut granules (a lysosome-related organelle) (PubMed:15843430). Plays a role in germ stem cell proliferation during larval development (PubMed:28285998).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Highly expressed in embryos and at L2 larval stage, and to a lower extent in subsequent larval stages and in adults.
messages: Inhibited by wortmannin.
messages: Interacts with bec-1 (PubMed:16111945, PubMed:26783301). May interact with dyn-1 (PubMed:18425118).
messages: Nucleus outer membrane
messages: RNAi-mediated knockdown causes a defect in the clearance of apoptotic cell corpses in gonads, a loss of rab-5 recruitment to cell corpse-containing nascent phagosomes and a decrease in PI3P levels on phagosome membranes (PubMed:18425118, PubMed:22272187). In addition, causes a reduction in mig-14 and rme-8 association with puncta structures as well as an increase in mig-14 protein levels (PubMed:21183797). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998).
messages: Ubiquitous.
messages: phagocytic cup

6239:CELE C03D6.3
gene id: 6239:CELE_C03D6.3
uniprot id: Q17607
uniprot id: Q6A3Q2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus
messages: RNA triphosphatase activity is inhibited by magnesium.

6239:CELE B0252.2
gene id: 6239:CELE_B0252.2
uniprot id: Q10916
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Does not require zinc ions as a cofactor.
messages: Preferentially expressed in embryos, lower expression in later development.
messages: Secreted
messages: Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
messages: There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinases have been found in worms.

6239:CELE C49H3.3
gene id: 6239:CELE_C49H3.3
uniprot id: Q9GYQ6
names: Similarity
messages: Belongs to the learning-associated protein family.

6239:CELE F37C12.1
gene id: 6239:CELE_F37C12.1
uniprot id: Q20124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.

6239:CELE F35H8.3
gene id: 6239:CELE_F35H8.3
uniprot id: Q20082
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in vulval cells and all somatic gonad structures such as spermatheca, sheath cells, uterine cells and distal tip cells.
messages: No visible phenotype. Double knockout with lin-35 results in sterility, defects in gonad migration and vulval morphology.
messages: Nucleus
messages: Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.

6239:CELE F55G1.5
gene id: 6239:CELE_F55G1.5
uniprot id: Q20847
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE W10C8.6
gene id: 6239:CELE_W10C8.6
uniprot id: Q4W4Z6
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE T28D9.7
gene id: 6239:CELE_T28D9.7
uniprot id: Q10025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C50B6.7
gene id: 6239:CELE_C50B6.7
uniprot id: P91982
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Monomer.

6239:CELE F59D6.2
gene id: 6239:CELE_F59D6.2
uniprot id: O16339
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE Y57G11C.49
gene id: 6239:CELE_Y57G11C.49
uniprot id: Q6BEQ0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0240.4
gene id: 6239:CELE_B0240.4
uniprot id: Q8I4N3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope (By similarity). Plays a role in postmitotic nuclear pore complex assembly potentially by promoting localization of nuclear pore complex proteins to the nuclear rim (PubMed:35852146).
messages: Embryonic lethality ranges from 40% to 100% (PubMed:35852146). One-cell stage embryos show shorter lengths with decreased pronuclei diameter resulting in decreased embryo nuclear size (PubMed:35852146). Nascent nuclear envelopes in the non-core regions are more continuous and contain fewer holes that may contain nascent nuclear pore complexes following initiation of furrow ingression (PubMed:35852146). Two- and four-cell stage embryos contain half the normal density of nuclear pore complexes (PubMed:35852146). Reduced localization of inner ring component npp-19 and Y-complex proteins to the nuclear rim, such as npp-6/nup160, npp-15/nup133, npp-18/seh1, npp-2/nup85 and mel-28/elys (PubMed:35852146). RNAi-mediated knockdown shows reduced nuclear import and a decrease in diameter of pronuclei (PubMed:35852146).
messages: Expressed during embryonic development.
messages: Nucleus membrane
messages: nuclear pore complex

6239:CELE F31F6.4
gene id: 6239:CELE_F31F6.4
uniprot id: G5EGN5
uniprot id: Q8WQF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

6239:CELE C15A11.1
gene id: 6239:CELE_C15A11.1
uniprot id: Q93208
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE W04D2.1
gene id: 6239:CELE_W04D2.1
uniprot id: H2L2C8
uniprot id: H2L2C9
uniprot id: Q23158
uniprot id: Q9XVU8
names: Similarity
messages: Belongs to the alpha-actinin family.

6239:CELE M05D6.6
gene id: 6239:CELE_M05D6.6
uniprot id: Q21525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

6239:CELE R12B2.5
gene id: 6239:CELE_R12B2.5
uniprot id: Q21955
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex (By similarity). Interacts with nhr-49, nhr-64 and sbp-1.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for regulated expression of genes controlling fatty acid desaturation by transcription factors including sbp-1 and nhr-49 (PubMed:16799563, PubMed:16651656). Involved in the response to simulated microgravity, in concert with sbp-1, probably acting in the intestine (PubMed:32448509).
messages: Expressed in the intestine and head neurons.
messages: Expressed throughout development.
messages: Expression increased by simulated microgravity.
messages: Nucleus

6239:CELE Y71G12A.3
gene id: 6239:CELE_Y71G12A.3
uniprot id: Q9BL53
uniprot id: X5LV96
names: Similarity
messages: Belongs to the TUB family.

6239:CELE F15A4.7
gene id: 6239:CELE_F15A4.7
uniprot id: O17820
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F56A6.1
gene id: 6239:CELE_F56A6.1
uniprot id: A0A0U1RML5
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE Y75B8A.9
gene id: 6239:CELE_Y75B8A.9
uniprot id: Q7K755
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE R05G6.9
gene id: 6239:CELE_R05G6.9
uniprot id: Q21756
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK20.6
gene id: 6239:CELE_ZK20.6
uniprot id: Q18673
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane
messages: Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping.
messages: Specifically expressed in pharyngeal cells and a single head neuron.

6239:CELE Y45F10B.1
gene id: 6239:CELE_Y45F10B.1
uniprot id: O62466
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE C26D10.3
gene id: 6239:CELE_C26D10.3
uniprot id: Q18213
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.

6239:CELE C02H6.1
gene id: 6239:CELE_C02H6.1
uniprot id: O17053
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05H10.2
gene id: 6239:CELE_T05H10.2
uniprot id: Q10002
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Nucleus

6239:CELE ZK1058.4
gene id: 6239:CELE_ZK1058.4
uniprot id: Q23382
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

6239:CELE F44F4.13
gene id: 6239:CELE_F44F4.13
uniprot id: Q20411
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol.
messages: Belongs to the nematode receptor-like protein sra family.
messages: Expressed in interneurons AIY and AVB in L1 larvae. In adults, strong expression is seen in AIY and AIA but only weak expression in AVB.
messages: Membrane
messages: Worms exhibit olfactory imprinting to benzaldehyde and isoamylalcohol.

6239:CELE K02E7.10
gene id: 6239:CELE_K02E7.10
uniprot id: O17255
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F14F7.3
gene id: 6239:CELE_F14F7.3
uniprot id: O17807
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y104H12D.3
gene id: 6239:CELE_Y104H12D.3
uniprot id: Q966E7
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE C05E11.5
gene id: 6239:CELE_C05E11.5
uniprot id: Q17663
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C36C9.2
gene id: 6239:CELE_C36C9.2
uniprot id: Q9TZL0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE H03A11.1
gene id: 6239:CELE_H03A11.1
uniprot id: Q9XTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM20 family.
messages: Golgi apparatus membrane
messages: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.
messages: Secreted

6239:CELE F46C8.6
gene id: 6239:CELE_F46C8.6
uniprot id: P34688
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.

6239:CELE Y22F5A.3
gene id: 6239:CELE_Y22F5A.3
uniprot id: A5PEW5
uniprot id: O62414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

6239:CELE H22D14.1
gene id: 6239:CELE_H22D14.1
uniprot id: G5EG35
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F55G1.2
gene id: 6239:CELE_F55G1.2
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE F22B8.6
gene id: 6239:CELE_F22B8.6
uniprot id: K8ESE2
uniprot id: O45391
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

6239:CELE C35D10.5
gene id: 6239:CELE_C35D10.5
uniprot id: Q18485
names: Similarity
messages: Belongs to the CBP3 family.

6239:CELE Y49E10.24
gene id: 6239:CELE_Y49E10.24
uniprot id: Q9XTU0
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y46G5A.30
gene id: 6239:CELE_Y46G5A.30
uniprot id: G5EBM5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Cell membrane
messages: Expressed in the INT-9 cells and posterior cells of the alimentary canal of the intestine, gut epithelial cells, the pharynx of some worms, two cells of the rectal gland, and in DVA, DVB and DVC neurons and amphid sensory neurons ASI, ADF and ASK neurons.
messages: Impaired capacity to form and maintain dauer larvae upon starvation (PubMed:23580723). RNAi-mediated knockdown in a pept-1 (lg601) mutant background results in a reduced number of progeny (PubMed:30560135). Dietary supplementation with glutamate does not rescue this phenotype (PubMed:30560135).
messages: Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid (PubMed:23580723) (Probable). May additionally have a role in potassium-dependent amino acid absorption (PubMed:23580723). In response to the availability of amino acid nutrients, may play a role in dauer formation (PubMed:23580723). May play a role in promoting fertility (PubMed:30560135).

6239:CELE T05A1.2
gene id: 6239:CELE_T05A1.2
uniprot id: Q22183
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y54G2A.77
gene id: 6239:CELE_Y54G2A.77
uniprot id: U4PDY0
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C13C4.4
gene id: 6239:CELE_C13C4.4
uniprot id: O01926
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

6239:CELE Y69A2AR.15
gene id: 6239:CELE_Y69A2AR.15
uniprot id: Q95XI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K04G2.2
gene id: 6239:CELE_K04G2.2
uniprot id: Q21221
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in a subset of neurons including AIY, HSN, ADF, AFD, AWC, AWB and NSM, hypodermis, pharyngeal muscle and intestine.
messages: Expressed in larvae and adults.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (By similarity). Acts in sensory neurons including AWC to regulate starvation-induced thermotaxis plasticity and salt learning behavior.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization and localization to sensory neuron endings.

6239:CELE T25C12.3
gene id: 6239:CELE_T25C12.3
uniprot id: G5ECR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZC412.2
gene id: 6239:CELE_ZC412.2
uniprot id: Q23310
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed asymmetrically in ASEL sensory neuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4 (PubMed:23664973, PubMed:19523832).
messages: Homodimer.
messages: The extracellular domain is required for the direct sensing of alkaline pH.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium

6239:CELE C05D10.2
gene id: 6239:CELE_C05D10.2
uniprot id: Q11179
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280, PubMed:28745435). Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance (PubMed:28842414). Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2 (PubMed:28745435). Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, probably by restricting expansion of the subcellular sensory compartment at the dendrite ending (PubMed:29879119).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cell junction
messages: Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.
messages: Expressed in all larval stages.
messages: Expressed in the URX neuron and in many other head sensory neurons (PubMed:29879119). Isoform a: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons. Isoform c: Expressed in head and tail ciliated sensory neurons, and in mid-body neurons.
messages: Perikaryon
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: Viable, but males display irregular mating behavior (PubMed:28745435). Ciliary defects in ciliated sensory neurons include impaired extension of dendrites, and abnormal amphid and phasmid sensillum morphology (PubMed:28745435, PubMed:29021280). Homozygotes present the swimming-induced paralysis (Swip) phenotype (PubMed:28842414).
messages: cilium
messages: cilium axoneme
messages: cilium basal body
messages: cilium membrane
messages: dendrite

6239:CELE C27A7.1
gene id: 6239:CELE_C27A7.1
uniprot id: P90754
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Membrane
messages: Probable phosphodiesterase.

6239:CELE AH9.4
gene id: 6239:CELE_AH9.4
uniprot id: Q10907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE R02C2.4
gene id: 6239:CELE_R02C2.4
uniprot id: A0A0K3AVS8
uniprot id: O44543
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T19C3.8
gene id: 6239:CELE_T19C3.8
uniprot id: P49594
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Component of a complex containing fem-1, fem-2 and fem-3 (PubMed:23760267). Interacts (via N-terminus) with fem-1 and fem-3 (PubMed:17609115, PubMed:23760267, PubMed:8824590). Component of the CBC(fem-1) E3 ubiquitin-protein ligase complex, at least composed of cul-2, elc-1, tra-1, fem-1, fem-2 and fem-3; mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (PubMed:17609115). Interacts with tra-1 (PubMed:17609115). Interacts with sel-10 (PubMed:15306688).
messages: Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin-dependent protein kinase unc-43/CAMKII in vitro (PubMed:11559703, PubMed:23760267). Involved in the regulation of sex determination (PubMed:8824590). Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes (PubMed:17609115). Promotes apoptosis (PubMed:11559703).

6239:CELE F45F2.1
gene id: 6239:CELE_F45F2.1
uniprot id: Q22980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE H21P03.3
gene id: 6239:CELE_H21P03.3
uniprot id: Q9U3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Golgi apparatus membrane
messages: Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product. Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.

6239:CELE Y40H7A.10
gene id: 6239:CELE_Y40H7A.10
uniprot id: Q9XWA4
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE ZK632.13
gene id: 6239:CELE_ZK632.13
uniprot id: Q10120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-52 family.
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts with zft-11; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623).
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein (PubMed:16020796, PubMed:17075059). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:17075059). In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623).

6239:CELE T05A7.3
gene id: 6239:CELE_T05A7.3
uniprot id: Q22206
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE H01A20.1
gene id: 6239:CELE_H01A20.1
uniprot id: Q9XTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C36H8.1
gene id: 6239:CELE_C36H8.1
uniprot id: Q18503
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE B0035.5
gene id: 6239:CELE_B0035.5
uniprot id: Q27464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
messages: cytosol

6239:CELE C13B9.2
gene id: 6239:CELE_C13B9.2
uniprot id: Q09235
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

6239:CELE K07A1.12
gene id: 6239:CELE_K07A1.12
uniprot id: P90916
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (By similarity). Probable component of a NuRD-like complex, composed of at least lin-53 and hda-1 (PubMed:17075059). Interacts with lin-35 (PubMed:9875852). Interacts with hda-1; the interaction is direct (PubMed:9875852, PubMed:17075059). Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts with hcp-3 (PubMed:26904949).
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:25446273, PubMed:26904949). Synthetic multivulva class B (synMuvB) protein (PubMed:9875852). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:10704416, PubMed:17075059, PubMed:9875852).
messages: Decreased protein levels of DRM complex components including lin-9, lin-37, lin-52 and lin-54 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results slow larval growth (PubMed:17237514). RNAi-mediated knockdown results in embryonic lethality (PubMed:9875852, PubMed:26904949). RNAi-mediated knockdown leads to a reduction of hcp-3 and his-1 protein levels and to a depletion of hcp-3 on centromeres and a reduction of H3K27me3 levels on metaphase chromosomes (PubMed:26904949). RNAi-mediated knockdown results in chromosome segregation defects during mitosis (PubMed:25446273, PubMed:26904949).
messages: Nucleus
messages: Ubiquitously expressed in embryos and newly hatched larvae. Expressed in all P(3-8).p vulval precursor cells at the time of vulval induction and until after all cell divisions and vulval morphogenesis are complete.
messages: centromere

6239:CELE C12D5.2
gene id: 6239:CELE_C12D5.2
uniprot id: Q17929
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T02G5.9
gene id: 6239:CELE_T02G5.9
uniprot id: Q22099
uniprot id: Q95ZQ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: Cytoplasm
messages: Homodimer.
messages: It is likely that the same gene provides both this cytoplasmic isoform and an additional mitochondrial isoform.
messages: RNAi-mediated knockdown results in an arrest at an early larval stage. In adults, causes a 80 percent reduction in progeny size and a 50 percent increase in eIF2alpha phosphorylation.

6239:CELE Y6E2A.9
gene id: 6239:CELE_Y6E2A.9
uniprot id: O45976
uniprot id: Q7K7S6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE M04B2.3
gene id: 6239:CELE_M04B2.3
uniprot id: Q21501
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y38F2AL.5
gene id: 6239:CELE_Y38F2AL.5
uniprot id: Q9N418
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE D2023.5
gene id: 6239:CELE_D2023.5
uniprot id: O17730
names: Disruption Phenotype
names: Domain
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
messages: Knockdown and RNAi cause reduced lifespan. Knockdown reduced brood size and halved the production of H(2)S.

6239:CELE C10G6.1
gene id: 6239:CELE_C10G6.1
uniprot id: Q17902
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a dynein-regulating complex composed of at least bicd-1, dlc-1 and egal-1.
messages: Nucleus envelope
messages: Part of a complex with bicd-1 and dlc-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells.
messages: RNAi-mediated knockdown results in animals that are viable. However, animals display a small, but significant, defect in nuclear migrations in hyp7 hypodermal precursor cells where an average of 3%, and up to 21% in a single animal, of nuclei fail to migrate.

6239:CELE W02B3.2
gene id: 6239:CELE_W02B3.2
uniprot id: Q09639
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Defective egg-laying with mutants retaining 35 eggs compared to 13-14 eggs in wild-type worms (PubMed:28213524, PubMed:28968387). Reduced serotonin levels, increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid, increased levels of amine oxidase amx-2 in early adult stages and reduced levels of phosphorylated amx-2 (PubMed:28213524). Defective locomotion and reduced body length (PubMed:28968387).
messages: Expressed in many neurons in the adult including the ASH neurons and other sensory neurons, many interneurons, and motor neurons of the ventral nerve cord (PubMed:15157420). Expressed broadly in head neurons and is detected in several head acetylcholine neurons including the AVA, AVB, AVD and AVE premotor interneurons, the SMD and RMD head motor neurons, and the AIN, AIY, SIA, SIB and SAA interneurons (PubMed:28968387). Expressed in HSN motor neurons and VC4/VC5 motor neurons (PubMed:28213524). Also expressed in vulval muscle cells (PubMed:15157420, PubMed:28213524).
messages: Expression is observed in embryos as early as the 20-30 cell stage and persists throughout development and into adulthood.
messages: Interacts with amx-2; the interaction promotes phosphorylation of amx-2.
messages: Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis (PubMed:15157420). Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations (PubMed:16407969). Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin (PubMed:28213524). Acts in head acetylcholine neurons to positively regulate locomotion (PubMed:28968387). Inactivates dopamine receptor dop-3 which leads to inactivation of guanine nucleotide-binding protein G(o) subunit goa-1 and activation of the unc-77/nca-1 and nca-2 ion channel proteins (PubMed:28968387).
messages: The kinase domain is required for chemotaxis activity.

6239:CELE K06B4.12
gene id: 6239:CELE_K06B4.12
uniprot id: G5EGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE T27F2.3
gene id: 6239:CELE_T27F2.3
uniprot id: G5EFA2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IAP family.
messages: Chromosome
messages: Component of the CPC complex which consists of icp-1; csc-1; bir-1 and air-2. Within the complex, interacts with csc-1, icp-1 and air-2. Interacts with csc-1 in a zinc-dependent-manner; the interaction is direct.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:12707312, PubMed:10209096, PubMed:10983970). The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation (PubMed:12707312, PubMed:10983970). In the complex, required to direct the Aurora B/air-2 kinase to chromosomes (PubMed:12707312, PubMed:10983970). Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis (PubMed:10209096, PubMed:10983970). Required for the localization of the kinetochore component hcp-1 to chromosomes (PubMed:10983970). Involved in the positive regulation of transcription (PubMed:12682297). Involved in the transcriptional regulation of collagen genes (PubMed:17116281).
messages: Expressed in oocytes and sperm.
messages: Expressed throughout development and in adult animals, with high expression in embryos and in dividing cells (at protein level).
messages: Midbody
messages: RNAi-mediated knockdown results in high embryonic lethality (PubMed:10209096). Causes a failure in cytokinesis resulting in a lack of cellularization and in polyploidy (PubMed:10209096, PubMed:10983970). Defective extrusion of the polar body during oogenesis (PubMed:10209096, PubMed:10983970). Defects in chromosome condensation, compromised alignment and segregation of paired homologs and defects in spindle midzone formation during meiosis and mitosis (PubMed:10983970). Disruption of air-2 and hcp-1 localization to chromosomes (PubMed:10983970). Decreased phosphorylation of histone H3 'Ser-10' and decreased acetylation of histone H3 'Lys-14' and 'Lys-9' (PubMed:10983970, PubMed:12682297). Surviving animals exhibit a shorter and stouter body morphology, slow uncoordinated movements, are egg-laying defective, have abnormal germ line growth and exhibit protruding vulvas (PubMed:12682297). Decrease in the transcription of several genes including collagen genes (PubMed:12682297, PubMed:17116281).
messages: spindle

6239:CELE T05B4.3
gene id: 6239:CELE_T05B4.3
uniprot id: O16424
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W06D12.2
gene id: 6239:CELE_W06D12.2
uniprot id: O45891
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y71G10AR.4
gene id: 6239:CELE_Y71G10AR.4
uniprot id: Q33BL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

6239:CELE Y47D3A.17
gene id: 6239:CELE_Y47D3A.17
uniprot id: A7DTF3
uniprot id: Q9U2C7
names: Similarity
messages: Belongs to the OSBP family.

6239:CELE Y56A3A.27
gene id: 6239:CELE_Y56A3A.27
uniprot id: O61660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Component of the BTR double Holliday Junction dissolution complex composed of at least him-6, top-3, rmh-1 and rmif-2, which is involved in double strand break repair in the germline (Probable). May interact with rmh-1 (PubMed:27011106).
messages: Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable). Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
messages: Nucleus

6239:CELE Y37E11AR.3
gene id: 6239:CELE_Y37E11AR.3
uniprot id: Q965X9
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. NAEs are bioactive lipids that are involved in diverse physiological processes such as growth and lifespan.
messages: No strong phenotype in the nape-2 deletion mutant, however its overexpression alters growth and lifespan when grown at 15 degrees Celsius compared to 25 degrees Celsius.
messages: Predominantly expressed in the pharynx, also highly expressed in the dorsal and ventral nerve cords, as well as in the vulval muscles of hermaphrodites.

6239:CELE F36D3.2
gene id: 6239:CELE_F36D3.2
uniprot id: O45460
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK783.1
gene id: 6239:CELE_ZK783.1
uniprot id: I6Z0I7
uniprot id: I7J4C8
uniprot id: I7J4C9
uniprot id: I7K4J2
uniprot id: I7K4J6
uniprot id: I7LFE6
uniprot id: I7LHV8
uniprot id: I7LHV9
uniprot id: Q23587
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C54G4.4
gene id: 6239:CELE_C54G4.4
uniprot id: Q18849
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK1058.1
gene id: 6239:CELE_ZK1058.1
uniprot id: Q23381
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Homodimer.
messages: Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity).
messages: Mitochondrion matrix

6239:CELE C33A12.6
gene id: 6239:CELE_C33A12.6
uniprot id: A0A061AKV1
uniprot id: Q18361
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE ZK856.11
gene id: 6239:CELE_ZK856.11
uniprot id: Q23646
names: Similarity
messages: Belongs to the EIF1AD family.

6239:CELE C29E4.3
gene id: 6239:CELE_C29E4.3
uniprot id: P34342
names: Function
names: Subcellular Location Annotation
messages: GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
messages: Nucleus

6239:CELE H23N18.1
gene id: 6239:CELE_H23N18.1
uniprot id: Q9TXZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C14C6.5
gene id: 6239:CELE_C14C6.5
uniprot id: A0A0K3AXM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F12F6.7
gene id: 6239:CELE_F12F6.7
uniprot id: Q19366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer with subunits of 125 kDa and 50 kDa.
messages: Nucleus
messages: The function of the small subunit is not yet clear.

6239:CELE C29F4.1
gene id: 6239:CELE_C29F4.1
uniprot id: Q18302
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE M03C11.1
gene id: 6239:CELE_M03C11.1
uniprot id: Q21483
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F26H11.1
gene id: 6239:CELE_F26H11.1
uniprot id: O45406
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: kinetochore

6239:CELE F17E9.8
gene id: 6239:CELE_F17E9.8
uniprot id: O61519
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE T12E12.4
gene id: 6239:CELE_T12E12.4
uniprot id: Q8WQC9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Functions in mitochondrial division (PubMed:18722182, PubMed:10619028, PubMed:15716954, PubMed:19327994). Functions in peroxisomal division (By similarity). Mediates membrane fission, perhaps mainly of the mitochondrial outer membrane (PubMed:10619028). Mitochondrial fission may be promoted by recruitment to mitochondrial membranes via the egl-1/ced-9 complex (PubMed:21949250). Involved in the coordination of mitochondrial division with autophagy in response to acute heat stress during larval development (PubMed:33734301). Plays a role in apoptosis by promoting mitochondrial elimination and cell-death execution, acting downstream of caspase ced-3, and perhaps independently of FIS1-related protein fis-2, caspase ced-9 and apoptosis-inducing factor AIFM/wah-1 (PubMed:15716954, PubMed:18722182). Role in promoting apoptosis dependent upon cleavage of drp-1 by ced-3 (PubMed:18722182). Involved in negatively modulating longevity in concert with the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:21463460).
messages: GTPase activity is increased by binding to phospholipid membranes.
messages: Highly expressed in neurons, in intestinal cells and in the body wall, pharyngeal, and vulval muscles.
messages: Interacts (via residues 280-502) with caspase ced-9; the interaction is enhanced by GTP rather than GDP; the interaction is probably direct and may occur at the mitochondrion.
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown causes embryonic lethality; onset of lethality is delayed by 12 hr in a caspase ced-3 mutant background (PubMed:10619028). Extremely disorganized gonads, including many nuclei without mitochondria, large clusters of mitochondria without nuclei and cells without either nuclei or mitochondria (PubMed:10619028). Substantial increase in mean lifespan in age-1 mutant background (PubMed:21463460). Substantial increase in mean lifespan in daf-2 mutant (PubMed:21463460).
messages: cytosol

6239:CELE C16C10.5
gene id: 6239:CELE_C16C10.5
uniprot id: Q09251
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RNF121 family.
messages: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates such as the beta-integrin subunit pat-3, promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:20357004). Negatively regulates the unfolded protein response to reduce endoplasmic reticulum stress (PubMed:20357004). Required for the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439). Plays a role in germline and gonad development (PubMed:20357004).
messages: Endoplasmic reticulum membrane
messages: Expressed in body wall muscles, the hypodermis, seam cells, vulval cells, spermathecal cells, uterine cells and the distal tip cell (at protein level).
messages: Golgi apparatus membrane
messages: RNAi-mediated knockdown in combination with tunicamycin treatment, which is an inhibitor of N-glycosylation, results in increased expression of hsp-4 in the intestine indicating endoplasmic reticulum stress and activation of the unfolded protein response.

6239:CELE F44C8.7
gene id: 6239:CELE_F44C8.7
uniprot id: G5EBK5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y18D10A.13
gene id: 6239:CELE_Y18D10A.13
uniprot id: Q9XW10
names: Function
names: Similarity
messages: Belongs to the dopey family.
messages: May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation.

6239:CELE C14C10.3
gene id: 6239:CELE_C14C10.3
uniprot id: E3W740
uniprot id: Q17973
uniprot id: Q52GY7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C24F3.6
gene id: 6239:CELE_C24F3.6
uniprot id: Q9NAR3
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y53H1B.6
gene id: 6239:CELE_Y53H1B.6
uniprot id: Q9XU14
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C30B5.9
gene id: 6239:CELE_C30B5.9
uniprot id: C8JQP7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y116A8A.7
gene id: 6239:CELE_Y116A8A.7
uniprot id: Q9U2V8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F15C11.2
gene id: 6239:CELE_F15C11.2
uniprot id: G5EFF7
names: Disruption Phenotype
names: Function
names: Induction
names: Tissue Specificity
messages: Expressed in the pharynx, hypodermis, intestine and head neurons (PubMed:29666234). Upon ER stress, expressed predominantly in pharyngeal muscle, hypodermis and intestine (PubMed:19822669).
messages: Induced upon ER stress.
messages: May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669). Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Collaborates with POST (F36D4.5) in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also acts as a regulator of DNA repair by inhibiting homologous recombination repair, thereby redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738).
messages: RNAi-mediated knockdown causes a reduction in lifespan (PubMed:19822669). Induces ER stress characterized by the expression of hsp-4, the accumulation of ubiquitinated proteins and an increase in ubxn-4 expression (PubMed:19822669). Mutants display increased homologous recombination repair in response to DNA damage compared to wild-type worms (PubMed:30612738). Worms lacking both POST (F36D4.5) and ubql-1 have a shorter lifespan and display an accumulation of ubiquitinated proteins in the nucleus (PubMed:29666234).

6239:CELE Y54E5A.1
gene id: 6239:CELE_Y54E5A.1
uniprot id: G5EC63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
messages: Membrane

6239:CELE F35G12.7
gene id: 6239:CELE_F35G12.7
uniprot id: Q20051
names: Similarity
messages: Belongs to the CutA family.

6239:CELE F55F8.2
gene id: 6239:CELE_F55F8.2
uniprot id: P91340
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

6239:CELE D2021.2
gene id: 6239:CELE_D2021.2
uniprot id: H2KYE9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE EEED8.9
gene id: 6239:CELE_EEED8.9
uniprot id: Q09298
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Mitochondrion
messages: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy (PubMed:25896323).
messages: RNAi-mediated knockdown in daf-2, isp-1, or clk-1 mutant backgrounds suppresses their increased lifespan phenotype.

6239:CELE ZC262.3
gene id: 6239:CELE_ZC262.3
uniprot id: P34595
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F47C10.6
gene id: 6239:CELE_F47C10.6
uniprot id: O01558
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H13N06.3
gene id: 6239:CELE_H13N06.3
uniprot id: Q9XTQ5
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the gob-1 trehalose phosphatase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
messages: Expression first seen at the 8E cell stage in the embryonic intestine. Expression continues to and includes adulthood. Beginning at the comma stage, additional expression is seen in the head and possibly in the hypodermis. By the twofold stage and continuing into adulthood, expression becomes increasingly widespread, with strong staining in the intestine, pharynx, hypodermis, body wall muscle, tail, and unidentified head neurons.
messages: Lethal at early larval stage. Mutant larvae show intestinal defects, and a high proportion exhibit gut obstruction (gob). No visible phenotype when gob-1 is down-regulated together with the trehalose phosphate synthases tps-1 and tps-2.
messages: Ubiquitously expressed. Strong expression in intestine.

6239:CELE F28C12.7
gene id: 6239:CELE_F28C12.7
uniprot id: O17846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE Y54G9A.3
gene id: 6239:CELE_Y54G9A.3
uniprot id: B7FAS2
uniprot id: G5EE44
uniprot id: Q9XWG9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE W01B6.7
gene id: 6239:CELE_W01B6.7
uniprot id: P17656
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Low level expression from embryos at comma stage to adult; maximal level in dauer larvae.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
messages: Syncytial dorsal and ventral epidermis.

6239:CELE C25G4.2
gene id: 6239:CELE_C25G4.2
uniprot id: Q18169
names: Similarity
messages: Belongs to the LovG family.

6239:CELE C15H11.5
gene id: 6239:CELE_C15H11.5
uniprot id: O17585
names: Subcellular Location Annotation
messages: centromere

6239:CELE D1065.1
gene id: 6239:CELE_D1065.1
uniprot id: A0A131MBM4
uniprot id: A0A131MCH9
uniprot id: A0A131MD93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE F21H7.9
gene id: 6239:CELE_F21H7.9
uniprot id: O62179
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed asymmetrically in ASE left (ASEL) sensory neuron. Expressed in excretory gland and canal cell.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE W02D3.5
gene id: 6239:CELE_W02D3.5
uniprot id: O01812
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE R03D7.5
gene id: 6239:CELE_R03D7.5
uniprot id: Q09595
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

6239:CELE ZK1025.9
gene id: 6239:CELE_ZK1025.9
uniprot id: Q9XXL8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C04F6.1
gene id: 6239:CELE_C04F6.1
uniprot id: P06125
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the intestine of adult hermaphrodites.
messages: High sequence similarity with other vitellogenin genes means that assigning functions to individual proteins is difficult; authors sometimes refer to VITs or vitellogenins.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). Together with other vitellogenins, may play a role in modulating life-span, acting via induction of autophagy and lysosomal lipolysis (PubMed:26671266).
messages: Secreted
messages: Simultaneous RNAi-mediated knockdown of vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life span, causes accumulation of neutral lipid and an increase in lgg-1 foci in the proximal intestine; however, does not affect fertility or pharyngeal pumping rates (PubMed:26671266). Expression of transcription factors pha-4 and daf-16 are increased (PubMed:26671266).
messages: Vitellogenin 5 undergoes little if any processing before being packaged into yolk platelets.

6239:CELE C44B7.8
gene id: 6239:CELE_C44B7.8
uniprot id: Q18597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

6239:CELE C14B1.5
gene id: 6239:CELE_C14B1.5
uniprot id: P49958
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase (By similarity).
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase.

6239:CELE B0285.5
gene id: 6239:CELE_B0285.5
uniprot id: P46555
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the D-glucuronyl C5-epimerase family.
messages: Cell membrane
messages: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts (PubMed:26022293).
messages: Expression in comma stage embryos is strong in the hypodermis and intestine and weaker in the head region. In late embryos, larval, and adult stages, expressed primarily in hypodermis and intestine.
messages: Homodimer.
messages: Irregular positioning of the AQR and PQR neurons in larva at the L4 stage.
messages: basement membrane

6239:CELE D1037.3
gene id: 6239:CELE_D1037.3
uniprot id: Q9TYS3
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6239:CELE F01D4.6
gene id: 6239:CELE_F01D4.6
uniprot id: P09088
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the mechanosensory neurons ALML, ALMR, PLML, PLMR, AVM and PVM, and the FLPL and FLPR neurons.
messages: Interacts with unc-86; the heterooligomer binds to the promoters of mec-3, mec-4 and mec-7.
messages: Nucleus
messages: Transcription factor (PubMed:26096732, PubMed:10899123). Specifies differentiation of the set of six touch receptor neurons (TRNs) (PubMed:2898300). May positively modulate expression of both its own gene and also of homeobox ARX homolog alr-1 in TRNs, forming a positive feedback loop with alr-1, thereby restricting the variability of expression of mec-3 (PubMed:21368126). Required to determine the identity of ALM sensory neurons, acting by interacting with unc-86, thereby preventing unc-86 cooperating with pag-3 to induce BDU-neuron specific genes (PubMed:26096732). Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter (PubMed:1361171, PubMed:10899123). Promotes outgrowth of lateral dendritic branches on the PVD nociceptive neurons, probably acting both directly, and upstream of zinc finger protein egl-46 (PubMed:29031632).

6239:CELE B0563.4
gene id: 6239:CELE_B0563.4
uniprot id: Q11080
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6239:CELE F30F8.10
gene id: 6239:CELE_F30F8.10
uniprot id: Q7YX26
names: Similarity
messages: Belongs to the acetyltransferase family. NAA60 subfamily.

6239:CELE D1053.1
gene id: 6239:CELE_D1053.1
uniprot id: Q18938
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily. Zeta family.
messages: Cytoplasm

6239:CELE Y57A10A.25
gene id: 6239:CELE_Y57A10A.25
uniprot id: Q9NA76
names: Similarity
messages: Belongs to the CAF1 family.

6239:CELE F45H10.3
gene id: 6239:CELE_F45H10.3
uniprot id: O02267
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

6239:CELE F29B9.6
gene id: 6239:CELE_F29B9.6
uniprot id: Q95017
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1, Polycomb protein sop-2, and intermediate filament proteins, such as ifb-1 (PubMed:15107848, PubMed:15689373, PubMed:24933177). Required for embryonic development, fertility, vulval morphogenesis, inhibition of vulval cell fates, lifespan, and neuromuscular activity (PubMed:24933177).
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Interacts with brd-1 and rad-51 (PubMed:14711411). Interacts with smo-1 and sop-2 (Ref.1, PubMed:15107848). Interacts with bet-1 (via BROMO domain 2) (PubMed:24349540). Interacts with isoforms 1 and 2 of X-box-binding protein xbp-1.
messages: Nucleus envelope
messages: RNAi-mediated knockdown results in sterility, embryonic lethality and sensitivity to radiation (PubMed:14711411, PubMed:25873636). RNAi-mediated knockdown causes a number of defects during the first embryonic mitotic division including loss of smo-1 from metaphase chromosomes, chromosome misalignment at metaphase, diminished spindle pole separation, slow chromosome segregation, decreased distance between chromosomes afer anaphase onset and increased air-2 levels in the spindle midzone (PubMed:25475837). RNAi-mediated knockdown results in ectopic tbx-2 expression in seam cells, the gut and in the syncytial hypodermis (PubMed:25873636). Exhibits abnormal localization and structure of intermediate filament protein ifb-1, such as altered filaments and aggregates, resulting in elongation defects of embryos.
messages: Ubiquitously expressed throughout development (at protein level) (PubMed:24933177). Expressed in early embryos in utero, in the pharynx and body-wall muscles during larval stages, becoming prominent in coelomocytes and the male tail in young adults (PubMed:24933177).

6239:CELE F41B5.4
gene id: 6239:CELE_F41B5.4
uniprot id: O16670
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F09G8.4
gene id: 6239:CELE_F09G8.4
uniprot id: P34389
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer-constitutive (daf-c) phenotype).
messages: Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons (PubMed:10801441).
messages: Membrane

6239:CELE R11A5.2
gene id: 6239:CELE_R11A5.2
uniprot id: O45717
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nudE family.
messages: Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871). Interacts with lis-1; the interaction is direct (PubMed:16996038). Interacts (via C-terminus) with unc-83; the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871).
messages: Expressed in ventral cord neurons, the pharynx, seam cells of the hypodermis and in vulval muscle cells.
messages: Nucleus envelope
messages: Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: RNAi-mediated knockdown results in viable animals, but a small, but significant number of animals have nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in impaired locomotion, stiffened appearance and an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).

6239:CELE T28F2.3
gene id: 6239:CELE_T28F2.3
uniprot id: O02637
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

6239:CELE T05G11.6
gene id: 6239:CELE_T05G11.6
uniprot id: Q9XXJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F15B10.1
gene id: 6239:CELE_F15B10.1
uniprot id: O44166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

6239:CELE C26E6.4
gene id: 6239:CELE_C26E6.4
uniprot id: Q10578
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
messages: Nucleus
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

6239:CELE ZK637.11
gene id: 6239:CELE_ZK637.11
uniprot id: P30634
names: Similarity
messages: Belongs to the MPI phosphatase family.

6239:CELE C02B4.2
gene id: 6239:CELE_C02B4.2
uniprot id: Q17589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T09A5.8
gene id: 6239:CELE_T09A5.8
uniprot id: P45968
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Chromosome
messages: Expressed in every cell of the embryo (at protein level). In adults, expressed predominantly in the head region and the germline.
messages: Expression of unc-4 in all 6 VC motor neurons in contrast to wild-type expression which is only detected in the vulval VC neurons, leading to hyperinhibition of HSN neuron activity and egg-laying defects (PubMed:24348272). RNAi-mediated knockdown in an spr-5 mutant background suppresses progressive sterility and prevents accumulation of histone H3 'Lys-4' dimethylation (PubMed:24685137).
messages: Nucleus
messages: Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1) (PubMed:24685137). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons (PubMed:24348272).

6239:CELE ZK512.3
gene id: 6239:CELE_ZK512.3
uniprot id: P34641
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Plays a major role in programmed cell death.

6239:CELE K01D12.12
gene id: 6239:CELE_K01D12.12
uniprot id: G5EET3
names: Similarity
messages: Belongs to the FAX family.

6239:CELE F22F7.4
gene id: 6239:CELE_F22F7.4
uniprot id: A0A0K3ASE9
uniprot id: A0A0K3AXR0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F43G6.17
gene id: 6239:CELE_F43G6.17
uniprot id: I2HAG2
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

6239:CELE R11H6.3
gene id: 6239:CELE_R11H6.3
uniprot id: H9G344
names: Similarity
messages: Belongs to the globin family.

6239:CELE K08B4.1
gene id: 6239:CELE_K08B4.1
uniprot id: V6CLJ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Su(H) family.
messages: Component of a complex consisting of at least a lin-12/Notch intracellular domain (NICD), lag-1, and lag-3 (PubMed:16530045, PubMed:10830967, PubMed:18381292). An NICD product of lin-12/Notch, including the RBP-j associated molecule (RAM) and ankyrin repeat (ANK) domains, interacts directly with lag-1 (PubMed:16530045, PubMed:10830967, PubMed:18381292, PubMed:9003776).
messages: Expressed in the precursor anchor cell and ventral uterine precursor cell (Z1.ppp, Z1.ppa, Z4.aaa, and Z4.aap) before cell specification, at early larval stage L2 (PubMed:23615264). Expressed in the ventral uterine cell (VU), but not in the anchor cell (AC), after specification, at late larval stage L2 (PubMed:23615264). Expressed in a dynamic pattern in the vulval precursor cells (VPCs) during vulval induction in larval stage L3 (PubMed:32839181). Expressed in somatic gonad cells, the distal tip cell (DTC), and all sheath and spermathecal cells, as well as in polyploid intestinal cells, in both the larval L4 and adult stages.
messages: In young adults, expressed in germ cells in the distal most ~10 cell diameters of the progenitor zone (PZ), and also in late pachytene, diplotene and diakinesis of oogenesis.
messages: Nucleus
messages: RNAi-mediated knockdown ectopically up-regulates expression of hlh-6 outside pharyngeal gland cells.
messages: Transcriptional regulator that plays a central role in lin-12/Notch and glp-1/Notch signaling pathways, involved in cell-cell communication that regulate a broad spectrum of cell-fate determinations (PubMed:8625826). Binds directly to the 5'-[A/G]TGGGAA-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:8625826, PubMed:18706403, PubMed:23615264, PubMed:15297877, PubMed:32196486, PubMed:21737278). Acts as a transcriptional repressor when it is not associated with Notch proteins (By similarity). When in a complex with a Notch intracellular domain (NICD) product of lin-12/Notch or glp-1/Notch, and transcription regulator lag-3, it may act as a transcriptional activator that activates transcription of target genes(PubMed:18381292, PubMed:10830967, PubMed:32196486, PubMed:9003776). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively (By similarity). Autonomously required in the germline for the stem cell fate, acting in the glp-1-dependent transcriptional activation of genes, including lst-1 and sygl-1 (PubMed:32196486). Involved in cell-fate specification during reproductive system development, by positively autoregulating its own expression, in response to lin-12/Notch signaling (PubMed:23615264, PubMed:32839181). Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278). May repress expression of hlh-6, in a lin-12/Notch-independent manner (PubMed:18706403).

6239:CELE F25H5.5
gene id: 6239:CELE_F25H5.5
uniprot id: O17838
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C14F5.4
gene id: 6239:CELE_C14F5.4
uniprot id: Q09972
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE F58A4.3
gene id: 6239:CELE_F58A4.3
uniprot id: P34470
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, hcp-3 and H4 assembled in one hcp-3-H4 heterotetramer and two H2A-H2B heterodimers. The hcp-3-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (By similarity). Interacts with knl-2 (PubMed:17339379). Interacts with lin-53 (PubMed:26904949).
messages: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:10524621). Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11402065, PubMed:14522947, PubMed:16273096, PubMed:16950114, PubMed:16950115, PubMed:12080088, PubMed:15767665). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis (PubMed:23684975). Not required for chromosome segregation during meiosis (PubMed:16273096).
messages: Nucleus
messages: Present at higher lower (>95%) level than cpar-1 (at protein level).
messages: RNAi-mediated knockdown impacts chromosome segregation leading to abnormal chromatin distribution (PubMed:16950114, PubMed:17339379). Disrupts mel-28 localization to kinetochores (PubMed:16950115). Leads to cleavage furrow regression and failed cytokinesis during the second embryonic division (PubMed:23684975). RNAi-mediated knockdown abolishes the localization of hcp-6 at the centromeres of mitotic chromosomes (PubMed:12080088).
messages: centromere
messages: kinetochore

6239:CELE K04D7.2
gene id: 6239:CELE_K04D7.2
uniprot id: P54815
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Involved in intramitochondrial sorting of proteins.
messages: Mitochondrion outer membrane

6239:CELE F21A3.3
gene id: 6239:CELE_F21A3.3
uniprot id: O17829
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0399.1
gene id: 6239:CELE_B0399.1
uniprot id: G5ED53
uniprot id: G5EER9
uniprot id: G5EEZ9
uniprot id: G5EFI1
uniprot id: Q8I4D2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C39E9.3
gene id: 6239:CELE_C39E9.3
uniprot id: Q18537
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE F12E12.5
gene id: 6239:CELE_F12E12.5
uniprot id: Q9BLC4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in the somatic gonad.
messages: In the early larval stage of development, expressed in Z1.pa and Z4.ap distal tip cells and their descendants (PubMed:20026024). Not expressed in early embryos (PubMed:20026024).
messages: RNAi-mediated knockdown does not cause defects in somatic gonad development (PubMed:20026024). RNAi-mediated knockdown in a ehn-3 rd2 mutant background enhances the defects in gonadal development in the ehn-3 single mutant (PubMed:20026024).
messages: Together with ehn-3, may play a role in gonadogenesis.

6239:CELE Y71H9A.2
gene id: 6239:CELE_Y71H9A.2
uniprot id: Q9XWC6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6239:CELE C53B7.2
gene id: 6239:CELE_C53B7.2
uniprot id: Q18805
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F02E8.3
gene id: 6239:CELE_F02E8.3
uniprot id: Q19123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

6239:CELE F55A4.7
gene id: 6239:CELE_F55A4.7
uniprot id: Q94242
names: Similarity
messages: Belongs to the calponin family.

6239:CELE C33H5.10
gene id: 6239:CELE_C33H5.10
uniprot id: Q18407
names: Similarity
messages: Belongs to the FAM98 family.

6239:CELE C31H5.3
gene id: 6239:CELE_C31H5.3
uniprot id: B3WFZ2
uniprot id: G5EGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE T01A4.1
gene id: 6239:CELE_T01A4.1
uniprot id: Q86GV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in head neurons, ventral cord and tail neurons, body wall muscle, hypodermis, somatic gonad and intestine (PubMed:16547101). Isoform d is expressed specifically in AIA interneurons (PubMed:21414922).
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9188508). Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps (PubMed:18817734).
messages: Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).
messages: Perikaryon
messages: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: axon
messages: dendrite

6239:CELE C53B4.6
gene id: 6239:CELE_C53B4.6
uniprot id: Q18800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

6239:CELE F53B6.2
gene id: 6239:CELE_F53B6.2
uniprot id: P90884
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a guidance cue in the attraction of muscle membrane extensions (muscle arms) to the dorsal cord and in cooperation with unc-6 to the ventral cord via the netrin receptor unc-40 and via the unc-40 coreceptor eva-1 (PubMed:22014523, PubMed:25122090). Together with nrx-1, clusters netrin receptor unc-40 and neuroligin nlg-1 at postsynaptic sites of GABAergic NMJs, thereby promoting the recruitment of GABA(A) receptors at GABAergic synapses (PubMed:24896188, PubMed:26028575, PubMed:26028574). Prevents the recruitment of GABAergic receptors to cholinergic synapses (PubMed:24896188).
messages: Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs) (PubMed:22014523, PubMed:24896188, PubMed:25122090, PubMed:26028575, PubMed:26028574). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1 (PubMed:22014523, PubMed:26028575, PubMed:25122090, PubMed:24896188). Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms (PubMed:22014523). In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis (PubMed:22014523). The unc-40 coreceptor eva-1 is enhancing the responsiveness of unc-40 to the madd-4 guidance cue to attract the muscle arm extensions and AVM mechanosensory axons towards the dorsoventral midline (PubMed:25122090). Acts as a synaptic organizer and is required for the specification of inhibitory GABAergic and excitatory cholinergic identities of postsynaptic domains at neuromuscular junctions (NMJs) (PubMed:24896188, PubMed:26028575, PubMed:26028574). Required for the recruitment of unc-40 to both cholinergic and GABAergic NMJs (PubMed:26028575). Promotes the clustering of ACh receptors and GABA(A) receptors at postsynaptic sites during synaptogenesis (PubMed:24896188). The binding to the presynaptic adhesion protein nrx-1 and to the neuroligin nlg-1 at postsynaptic sites promotes clustering of GABAergic receptors at postsynaptic NMJs, thereby contributing to normal GABAergic synaptic transmission (PubMed:26028574).
messages: Disrupts the clustering of the cholinergic receptor subunits unc-29, unc-38 and acr-16 and the GABAergic receptor subunit unc-49 at postsynaptic domains of neuromuscular junctions (NMJs), and the receptors are redistributed to extrasynaptic areas (PubMed:24896188, PubMed:26028575). Loss of neuroligin receptor nlg-1 and netrin receptor unc-40 localization to NMJs (PubMed:26028575). Isoform a and isoform c: Defects in AChR localization to cholinergic synapses (PubMed:24896188). Decreased AChR-dependent currents triggered by motoneuron stimulation (PubMed:24896188). Isoform b: Extensive dorsal muscle arm extension defects and weaker ventral muscle arm extension defects (PubMed:24896188, PubMed:22014523). Relocalization of GABAergic receptors from GABAergic to cholinergic synapses (PubMed:24896188, PubMed:26028575). Redistribution of the neuroligin receptor nlg-1 from GABAergic to cholinergic NMJs (PubMed:26028575). In a unc-6 mutant background, extensive ventral muscle arm extension defects (PubMed:22014523). Loss of unc-40 localization at GABAergic NMJs (PubMed:26028575).
messages: Interacts with eva-1 (via the SUEL-type lectin domain) (PubMed:25122090). Interacts with unc-5 (PubMed:25122090). Interacts with unc-40; the interaction is required for the localization of unc-40 to postsynaptic domains (PubMed:25122090, PubMed:26028575). Isoform a forms homodimers and heterodimers with isoform b (PubMed:24896188). Isoform b forms homodimers and heterodimers with isoform a (PubMed:24896188). Isoform b interacts with nlg-1 (via extracellular domain); the interaction is required for nlg-1 localization to postsynaptic domains (PubMed:26028574, PubMed:26028575). Isoform b interacts (via the Ig-like C2-type domain) with nrx-1 (via C-terminus) (PubMed:26028574).
messages: Isoform a and isoform c: Promotes the clustering of acetylcholine receptors (AChR) at excitatory cholinergic synapses of NMJs via the netrin receptor unc-40.
messages: Isoform a: Expressed in larval stages L1 and L2 and in adult animals. Isoform b: Expressed in embryos, larval stages L1 and L2 and in adult animals.
messages: Isoform a: Expressed in the commissural GABAergic and cholinergic motor neurons in the first larval stage but only in the cholinergic motor neurons in later larval stages and in adult animals (PubMed:22014523). At the L1 larval stage, mainly localized at the nerve ring and at the dorsal cord (PubMed:24896188). Isoform b: Expressed in the commissural GABAergic and cholinergic motor neurons whose cell bodies reside in the ventral nerve cord and which extend axons into the ventral and dorsal nerve cord (PubMed:22014523, PubMed:24896188). Also expressed in the head neurons RIA, RIC, lateral IL1s, lateral IL2s, OLLs, RMEs and SABs, all of which extend axons into the nerve ring (PubMed:22014523, PubMed:24896188). Expressed in the embryogenic blast cells and the corresponding terminally differentiated ventral cord motor neurons and head neurons (PubMed:22014523).
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform a.
messages: Secreted
messages: Synapse
messages: The Ig-like C2-type domain is required for the attraction of the muscle arm extensions.
messages: axon
messages: extracellular matrix

6239:CELE T01C2.1
gene id: 6239:CELE_T01C2.1
uniprot id: Q966F9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

6239:CELE K04D7.4
gene id: 6239:CELE_K04D7.4
uniprot id: P28192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
messages: Membrane

6239:CELE F53H8.4
gene id: 6239:CELE_F53H8.4
uniprot id: Q20735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane
messages: Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product. Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.

6239:CELE T01D1.4
gene id: 6239:CELE_T01D1.4
uniprot id: P91416
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Cytoplasm
messages: Nucleus
messages: Probable inactive acireductone dioxygenase.
messages: This enzyme lacks one or more conserved metal-binding sites. It may be non-functional.

6239:CELE C10C5.3
gene id: 6239:CELE_C10C5.3
uniprot id: Q17898
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

6239:CELE C37A5.1
gene id: 6239:CELE_C37A5.1
uniprot id: O62095
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C55B7.6
gene id: 6239:CELE_C55B7.6
uniprot id: G5EED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE Y39G8B.3
gene id: 6239:CELE_Y39G8B.3
uniprot id: Q9U2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T07C4.2
gene id: 6239:CELE_T07C4.2
uniprot id: Q22292
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704).
messages: Nucleus
messages: RNAi-mediated knockdown causes about 5% embryonic lethality with 1-10% of hatching larvae displaying posterior morphological defects (PubMed:15102704, PubMed:15892873). Defective intercalation of dorsal hypodermis (PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-9 causes at least 48% of embryos to fail to hatch and those that do display severe morphological defects and die as larvae (PubMed:15892873, PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-9 abolishes muscle expression of vab-7 (PubMed:15102704).
messages: Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704). Involved in regulating expression of vab-7 (PubMed:15102704). Appears to have partially redundant function to tbx-9 (PubMed:15066124).

6239:CELE ZC504.4
gene id: 6239:CELE_ZC504.4
uniprot id: Q23356
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Involved in cell migration and signal transduction (PubMed:11967148, PubMed:22732572). Important in several developmental processes including epidermal development, Q neuroblast migrations and muscle arm targeting. Required with ina-1/pat-3 to stabilize the commissural axons growth cone along a precise direction and are required for the cell to respond appropriately when signaling in the growth cone must change (PubMed:11967148). During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms (PubMed:22732572).
messages: Mutants exhibit premature branching of commissures (PubMed:11967148). RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis (PubMed:22732572). Double knockdown with mig-38 results in enhanced gonad DTC migration defects (PubMed:22732572).

6239:CELE F26B1.3
gene id: 6239:CELE_F26B1.3
uniprot id: P91276
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin alpha family.
messages: Cytoplasm
messages: Embryonic lethality associated with a terminal aneuploid phenotype: embryos display severe defects in nuclear envelope formation, accumulating nucleoporins and lamin in the cytoplasm (PubMed:12221121). Worms lacking both akir-1 and ima-2 show reduced gonad size and aberrant diakinesis oocyte formation; defects are caused by impaired meiotic recombination (PubMed:30563860).
messages: Expressed weakly in early larvae, levels of expression increase in larval stage 4 and adult stages when germ cells are continually proliferating.
messages: Forms a complex with an importin beta subunit (PubMed:11311162). Interacts with akir-1 (PubMed:30563860).
messages: Germline tissues (PubMed:11311162, PubMed:12221121). Expressed exclusively in germ line cells from the early embryonic through adult stages (PubMed:12221121).
messages: Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion (PubMed:11311162, PubMed:12221121, PubMed:30563860). Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity). Promotes docking of import substrates to the nuclear envelope (By similarity). Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei (PubMed:30563860).
messages: Nucleus
messages: Nucleus envelope

6239:CELE ZK265.4
gene id: 6239:CELE_ZK265.4
uniprot id: A0A0S4XRQ4
uniprot id: Q94398
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for cell specification of the RIA interneurons.

6239:CELE C06A8.1
gene id: 6239:CELE_C06A8.1
uniprot id: Q17693
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

6239:CELE F54H12.1
gene id: 6239:CELE_F54H12.1
uniprot id: P34455
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion
messages: Monomer.
messages: RNAi-mediated knockdown causes accumulation of citrate, leading to induction of the citrate-induced mitochondrial unfolded protein response (mtUPR).

6239:CELE F28C6.4
gene id: 6239:CELE_F28C6.4
uniprot id: Q19870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y24F12A.2
gene id: 6239:CELE_Y24F12A.2
uniprot id: A0A061ACG4
uniprot id: G5EGB3
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

6239:CELE Y111B2A.22
gene id: 6239:CELE_Y111B2A.22
uniprot id: Q9NEL2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Defects in feminization. Embryonic arrest.
messages: Nucleus
messages: Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development.

6239:CELE T07F10.4
gene id: 6239:CELE_T07F10.4
uniprot id: Q22316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

6239:CELE R10E11.4
gene id: 6239:CELE_R10E11.4
uniprot id: P34548
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. Required for embryonic development (PubMed:11005858). Involved in vulval epithelium invagination (PubMed:9927677). Required for axon regeneration after injury (PubMed:31371405).
messages: Membrane

6239:CELE T09D3.7
gene id: 6239:CELE_T09D3.7
uniprot id: Q86B33
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C25F9.2
gene id: 6239:CELE_C25F9.2
uniprot id: O62074
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE Y22D7AR.13
gene id: 6239:CELE_Y22D7AR.13
uniprot id: G5EGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE C30F12.6
gene id: 6239:CELE_C30F12.6
uniprot id: Q95YD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

6239:CELE K03B8.5
gene id: 6239:CELE_K03B8.5
uniprot id: Q21181
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C03B8.4
gene id: 6239:CELE_C03B8.4
uniprot id: Q11107
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: In the L3 stage, expressed in syncytial hypodermal cell 7, body wall muscles, intestinal cells, distal tip cells and many neurons.
messages: Interacts (via PLVPV motif) with chromobox protein homolog hpl-2 (via chromo (shadow subtype) domain); the interaction is direct and influences localization of hpl-2 to nuclear foci.
messages: Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism (PubMed:10880475, PubMed:16890929). May act in a common pathway with retinoblastoma-like protein homolog lin-35 and hpl-2 to influence the ER stress response in the intestine (PubMed:24715729). Plays a role in recruiting chromobox protein homolog hpl-2 to specific chromatin sites (PubMed:16890929).
messages: Nucleus
messages: RNAi-mediated knockdown causes various defects, including sterility, multiple vulvae, protruding vulva and arrested larvae (PubMed:10880475). Abolishes many hpl-2 nuclear foci (PubMed:16890929). Causes ectopic up-regulation of transcription of specific genes, such as lin-39 and lag-2 (PubMed:16890929).

6239:CELE F09E8.2
gene id: 6239:CELE_F09E8.2
uniprot id: Q19267
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CRELD family.
messages: Endoplasmic reticulum lumen
messages: Endoplasmic reticulum membrane
messages: Interacts with unc-29.
messages: Isoforms a: Widely expressed in tissues including body wall muscles, neurons, pharynx, hypodermis, seam cells, intestine and gonad (PubMed:30407909). Isoform b: Widely expressed in tissues including body wall muscles, neurons, pharynx, hypodermis, seam cells, intestine and gonad (PubMed:30407909).
messages: Promotes L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.
messages: Protein disulfide isomerase which associates with the unc-29 subunit of levamisole-sensitive nicotinic acetylcholine receptors (L-nAChR) to promote L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.
messages: Viable, with no defects in coordination (PubMed:30407909). Decreased number of synaptic nicotinic acetylcholine receptors (nAChRs) at neuromuscular junctions (PubMed:30407909). Isoform a: Deletion leads to reduced sensitivity to the nAChR agonist levamisole (PubMed:30407909). Isoform b: Deletion leads to sensitivity to levamisole as in wild-type (PubMed:30407909).

6239:CELE F45H11.1
gene id: 6239:CELE_F45H11.1
uniprot id: Q93727
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Expressed in ASJ sensory neurons, pharyngeal cells, rectal cells, intestine, seam cells, and vulval cells.
messages: Probable transcription factor which modulates gene expression, thereby acting as an ASJ sensory neuron terminal selector gene.
messages: RNAi-mediated knockdown abolishes expression of sulfotransferase ssu-1 and thioredoxin trx-1 in the ASJ sensory neurons, in adults, embryos and larvae.

6239:CELE Y51A2D.13
gene id: 6239:CELE_Y51A2D.13
uniprot id: Q8I4C7
uniprot id: Q9XXR6
names: Similarity
messages: Belongs to the phospholipase D family.

6239:CELE C44B7.5
gene id: 6239:CELE_C44B7.5
uniprot id: Q18594
names: Subcellular Location Annotation
messages: Secreted

6239:CELE EEED8.7
gene id: 6239:CELE_EEED8.7
uniprot id: Q09511
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: May play a functionally redundant role in embryogenesis.
messages: Nucleus

6239:CELE Y54H5A.1
gene id: 6239:CELE_Y54H5A.1
uniprot id: Q9N393
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F26A3.8
gene id: 6239:CELE_F26A3.8
uniprot id: G3MU40
uniprot id: G5ECM1
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE H27D07.3
gene id: 6239:CELE_H27D07.3
uniprot id: A0A0M7REP9
uniprot id: O61909
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T14E8.3
gene id: 6239:CELE_T14E8.3
uniprot id: Q6RYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the neurons of the head, ventral cord and tail with weak expression observed in body wall muscles and PVD neurons (PubMed:15378064). In the ventral cord, expressed strongly in GABAergic neurons with weaker expression in cholinergic motor neurons (PubMed:15378064). Expressed in cholinergic SIA neurons and octopaminergic RIC neurons (PubMed:19609300). In males, expressed in the dorsal and ventral spicule protractor and retractor muscles, and the sensory post-cloacal sensilla B (PCB) neuron (PubMed:23166505).
messages: G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity leading to the activation of an associated G-protein and downstream signaling pathways (PubMed:15378064, PubMed:16001968). Couples to G-proteins to inhibit adenylate cyclase (AC) activity and cAMP production (PubMed:15378064, PubMed:16001968). Antagonizes the D1-like dopamine receptor dop-1 to negatively regulate the rate of locomotion (PubMed:15378064). In GABAergic, RIC, and SIA neurons, antagonizes the function of dop-1 to play a role in behavioral plasticity and regulate the decision-making process when conflicting alternatives are present (PubMed:25536037). Antagonizes octopamine signaling in response to food by promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons (PubMed:19609300). This is most likely in association with the G(o)-alpha G-protein subunit goa-1 (PubMed:19609300). Promotes male mating behavior by antagonizing acetylcholine signaling to control the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location (PubMed:23166505).

6239:CELE C06B8.1
gene id: 6239:CELE_C06B8.1
uniprot id: O17573
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F11A10.1
gene id: 6239:CELE_F11A10.1
uniprot id: P54816
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure.

6239:CELE T09F5.1
gene id: 6239:CELE_T09F5.1
uniprot id: O62375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C26D10.2
gene id: 6239:CELE_C26D10.2
uniprot id: Q18212
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Interacts with rsr-1/SRm160.
messages: Nucleus
messages: RNAi-mediated knockdown prevents germ cells from entering meiosis and results in the accumulation of unspliced mRNAs in the cytoplasm.
messages: Required for spliced RNA export out of the nucleus (PubMed:23149939). May play a role in spliceosome assembly.

6239:CELE F58B6.2
gene id: 6239:CELE_F58B6.2
uniprot id: Q9TYU9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the formin homology family.
messages: Constitutively active protein required for microtubule and F-actin growth, structural maintenance and organization during excretory cell tubulogenesis.
messages: Defective cytoskeleton organization characterized by disrupted F-actin and microtubule dynamics leading to abnormal excretory cell tubulogenesis. Specifically, F-actin structure and organization in excretory cell canals throughout life is disrupted and microtubule organizing centers accumulate at the tips of excretory cell canals, with a strong reduction along the canals, and the direction of microtubule growth is altered.
messages: Expressed in the excretory cell and mostly accumulates at the tip of the excretory cell canals.
messages: cytoskeleton

6239:CELE T08D2.1
gene id: 6239:CELE_T08D2.1
uniprot id: A4F319
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE ZC412.3
gene id: 6239:CELE_ZC412.3
uniprot id: Q23307
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F41H10.8
gene id: 6239:CELE_F41H10.8
uniprot id: Q20303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme required for the formation of isoheptadecanoate (C17iso), which plays critical roles in animal development and growth.
messages: Expressed in the gut, neurons, pharynx and muscles of the vulva.
messages: Membrane

6239:CELE C03D6.6
gene id: 6239:CELE_C03D6.6
uniprot id: Q17604
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Expressed in 1- to 100-cell stage embryos.
messages: Interacts with gsp-1 and gsp-2; the interaction is direct.
messages: Involved in sister chromatid cohesion during mitosis and meiosis (PubMed:18923084, PubMed:22927794, PubMed:30921322). In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment (PubMed:18923084, PubMed:22927794, PubMed:29483514, PubMed:30921322). This in turn, drives germ cell immortality (PubMed:30921322). Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis (PubMed:18923084, PubMed:22927794).
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality in 57% of animals, and of the surviving progeny, there is a 6% increase in the number of males (Him phenotype) (PubMed:18923084). Defective sister chromatid cohesion during meiosis and mitosis (PubMed:18923084, PubMed:22927794). Mis-localized air-2 in oocytes at the diakinesis phase of prophase I in meiosis (PubMed:18923084, PubMed:22927794). Impaired meiotic DNA double-strand break repair as evidenced by increased rad-51 positive nuclei throughout late pachytene to early diplotene in gonads, and impaired number of crossover recombination events between chromatids (PubMed:22927794). Absent syp-1, a core component of the synaptonemal complex, at the pachytene stage of meiosis (PubMed:22927794). Reduced expression of the gsp-2 phosphatase (PubMed:30921322).

6239:CELE K03H1.2
gene id: 6239:CELE_K03H1.2
uniprot id: P34498
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
messages: Nucleus
messages: Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

6239:CELE F22E10.1
gene id: 6239:CELE_F22E10.1
uniprot id: Q19733
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C03A7.11
gene id: 6239:CELE_C03A7.11
uniprot id: O16506
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C25H3.5
gene id: 6239:CELE_C25H3.5
uniprot id: Q18184
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Secreted

6239:CELE Y38F1A.10
gene id: 6239:CELE_Y38F1A.10
uniprot id: G5EGQ3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed ubiquitously in early embryo. At the comma stage and at later embryonic stages expression is mainly restricted to the anterior region of the embryo and to the ventral cord. At the 1.5-fold embryonic stage, expression starts in pharynx and in several head and tail neurons and is maintained in adults. During L1 larval stage, expressed in ALM and PLM neurons and later in PVD and AVM neurons.
messages: Interacts with mlk-1; the interaction is independent of max-2 and mlk-1 kinase activities. Interacts with mig-2 (GTP-bound form).
messages: Isoforms a and c: Partial sensitivity to the heavy metal Cu(2+), which is characterized by a failure of larvae to reach adulthood. Partial reduction in basal kgb-1 phosphorylation and after Cu(2+) treatment (PubMed:20008556). Several DD and DC motoneuron axons fail to reach the dorsal cord. RNAi-mediated knockdown causes a similar phenotype but less severe. In max-2 and pak-1 double mutants, defect in axonal guidance is more severe. Animals are also uncoordinated, defective in egg laying and in distal tip cell (DTC) migration, morphology and guidance, and exhibit ventral enclosure defects (PubMed:17050621). A more severe phenotype has been reported where double mutant animals have embryonic morphogenesis defects resulting in lethality. The few surviving adults are sterile and often have truncated gonads which, in some cases, lack sperm. RNAi-mediated knockdown rescues embryonic lethality of pak-1 and pak-2 double mutants (PubMed:23390595).
messages: Perikaryon
messages: Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk-1/mek-1/kgb-1 pathway (PubMed:20008556). In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc-6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons (PubMed:18499456). Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstream of Rho GTPases (PubMed:17050621, PubMed:19023419, PubMed:23390595). In association with pak-2, plays a role in embryogenesis. In association with pak-1, may be involved in spermatogenesis (PubMed:23390595).
messages: dendrite

6239:CELE F59G1.7
gene id: 6239:CELE_F59G1.7
uniprot id: Q9TY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the frataxin family.
messages: Mitochondrion
messages: Monomer. Oligomer (By similarity).
messages: Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.

6239:CELE F26D2.9
gene id: 6239:CELE_F26D2.9
uniprot id: Q9XV63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K03E5.2
gene id: 6239:CELE_K03E5.2
uniprot id: H2KZW0
uniprot id: H2KZW1
uniprot id: O61848
names: Similarity
messages: Belongs to the calponin family.

6239:CELE B0285.8
gene id: 6239:CELE_B0285.8
uniprot id: P46558
names: Similarity
messages: Belongs to the choline/ethanolamine kinase family.

6239:CELE Y110A2AL.14
gene id: 6239:CELE_Y110A2AL.14
uniprot id: Q9N491
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
messages: Golgi apparatus membrane
messages: Worms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell.

6239:CELE T13A10.10
gene id: 6239:CELE_T13A10.10
uniprot id: Q7YXH5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y37E11AR.4
gene id: 6239:CELE_Y37E11AR.4
uniprot id: Q965X7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:25423491). NAEs are bioactive lipids that are involved in diverse physiological processes such as growth and lifespan (PubMed:21562563, PubMed:25423491).
messages: Expressed in interneurons that are in close proximity to the primary sensory neurons (PubMed:21562563). Predominantly expressed in the pharynx but can also be found in cell bodies of the dorsal and ventral nerve cords (PubMed:25423491).
messages: No strong phenotype in the nape-1 deletion mutant, however its overexpression alters growth and lifespan when grown at 25 degrees Celsius compared to 15 degrees Celsius.

6239:CELE Y57A10A.26
gene id: 6239:CELE_Y57A10A.26
uniprot id: Q9NA74
names: Similarity
messages: Belongs to the FAX family.

6239:CELE D2030.1
gene id: 6239:CELE_D2030.1
uniprot id: P90787
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE C14B9.2
gene id: 6239:CELE_C14B9.2
uniprot id: P34329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6239:CELE T23F1.7
gene id: 6239:CELE_T23F1.7
uniprot id: Q7JKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE C16C10.1
gene id: 6239:CELE_C16C10.1
uniprot id: Q09461
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

6239:CELE C07A12.7
gene id: 6239:CELE_C07A12.7
uniprot id: H2KYH5
uniprot id: Q95QX5
names: Similarity
messages: Belongs to the TOM1 family.

6239:CELE F59F3.5
gene id: 6239:CELE_F59F3.5
uniprot id: Q21041
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.

6239:CELE R11E3.2
gene id: 6239:CELE_R11E3.2
uniprot id: Q9TYX7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C01B4.5
gene id: 6239:CELE_C01B4.5
uniprot id: G5EFQ7
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C47A10.4
gene id: 6239:CELE_C47A10.4
uniprot id: O45306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F18C5.1
gene id: 6239:CELE_F18C5.1
uniprot id: Q19549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE Y38C1AB.5
gene id: 6239:CELE_Y38C1AB.5
uniprot id: G5ECT3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47D3A.30
gene id: 6239:CELE_Y47D3A.30
uniprot id: F3Y5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

6239:CELE C38H2.1
gene id: 6239:CELE_C38H2.1
uniprot id: I2HAA0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RUTBC family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Expressed in neurons in the head, tail and ventral nerve cord (at protein level).
messages: Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others (PubMed:22654674). GTPase activator for rab-2 (PubMed:22654674). In association with ric-19 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674).
messages: Interacts with rab-19 (PubMed:22654674). Interacts with ric-19; the interaction is direct and may be required for the activation of rab-2 and dense vesicle maturation in cholinergic motoneurons (PubMed:22654674). Interacts (via RUN domain) with rund-1 (PubMed:24698274). Does not interact with unc-108 (GTP-bound form) (PubMed:22654674).
messages: RNAi-mediated knockdown results in neuronal dense core vesicle trafficking defects whereby fewer dense core vesicles are transported to axons of the dorsal nerve cord.
messages: trans-Golgi network

6239:CELE ZK1067.4
gene id: 6239:CELE_ZK1067.4
uniprot id: Q23387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

6239:CELE T06E4.7
gene id: 6239:CELE_T06E4.7
uniprot id: Q22261
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y71H2B.10
gene id: 6239:CELE_Y71H2B.10
uniprot id: Q9N4F3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

6239:CELE ZK829.4
gene id: 6239:CELE_ZK829.4
uniprot id: Q23621
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

6239:CELE F54E12.4
gene id: 6239:CELE_F54E12.4
uniprot id: Q27876
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE B0546.4
gene id: 6239:CELE_B0546.4
uniprot id: O44440
names: Similarity
messages: Belongs to the yippee family.

6239:CELE W03D2.7
gene id: 6239:CELE_W03D2.7
uniprot id: O02119
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
messages: Expressed in pharyngeal gland cells and duct projections, coelomocytes and intestine.
messages: Has bacteriolytic activity against Gram-positive bacteria.
messages: Induced by Gram-positive bacterium M.nematophilum CBX102 infection but not by Gram-negative bacterium P.aeruginosa PAO1 infection.

6239:CELE F56F4.5
gene id: 6239:CELE_F56F4.5
uniprot id: O01840
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Expressed in the AVA interneuron.
messages: Expression is detected as early as the larval L1 stage and continues into the adult stage.
messages: Membrane
messages: Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)-independent manner. Shows H(+) channel activity in the absence of peptide substrates.

6239:CELE Y71A12C.2
gene id: 6239:CELE_Y71A12C.2
uniprot id: Q9XXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

6239:CELE F46G10.6
gene id: 6239:CELE_F46G10.6
uniprot id: Q18711
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAX family.
messages: Cytoplasm
messages: Down-regulated by fasting.
messages: Expressed in the intestine and in the AWC sensory neurons.
messages: May form homodimer (PubMed:19632181). Interacts (via N-terminus) with skn-1 isoforms a and c (PubMed:23040073).
messages: Nucleus
messages: RNAi-mediated knockdown causes a depletion of fat stores. RNAi-mediated knockdown in the intestine causes a fasting-like transcriptional response, characterized by the up-regulation of the lipl-1 gene transcription.
messages: Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability (PubMed:23604316, PubMed:29113111). Binds to the E-box motif 5'-CACGTG-3' (PubMed:19632181). Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis (PubMed:23604316). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression (PubMed:29113111). Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway (PubMed:27487365).

6239:CELE C02F4.2
gene id: 6239:CELE_C02F4.2
uniprot id: Q0G819
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+) (By similarity). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+) (PubMed:12221132). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A (PubMed:12221132). The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A (By similarity). Inhibited by immunosuppressant cyclosporin A (CsA) (PubMed:12221132).
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132, PubMed:16481400, PubMed:22300764, PubMed:23805378). Dephosphorylates arrd-17 (PubMed:22300764). Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation (PubMed:23805378). Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534' (PubMed:16481400). Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium (PubMed:16481400). Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons and sensitivity to CO2 levels (PubMed:18524955, PubMed:11879652). Plays a role in modulating temperature-dependent calcium responses in AFD neurons and together with tax-6 inhibitor rcan-1 regulates thermotaxis in AFD neurons (PubMed:26232604). Regulates expression of rcan-1 (PubMed:12684004). In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1 (PubMed:26232604). Plays a role in egg-laying, body-size, fertility, growth, movement and cuticle development (PubMed:12684004, PubMed:15522306, PubMed:17113567, PubMed:22300764, PubMed:27871170). Negatively regulates lifespan (PubMed:19279398). Promotes transcription activator crtc-1 nuclear localization, probably by dephosphorylating crtc-1 and thereby negatively regulates lifespan (PubMed:21331044). Regulates expression of chemoreceptor srt-2 in AWC neurons probably downstream of Ser/Thr kinase kin-29 (PubMed:17113567). Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870). Plays a role in several endocytic processes including in coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307). May negatively regulate excitatory GABA receptor exp-1 during enteric muscle con…
messages: Cytoplasm
messages: Expressed in embryos and at all larval stages.
messages: Expressed in head and tail neurons, ventral nerve cord, body wall and vulva muscles, sperm and spermatheca (PubMed:12221132). Expressed in hypodermal seam cells (PubMed:15522306). Expressed in intestinal and anal depressor muscles (PubMed:16084527). In male, expressed in CEM, HOB and ray RnB neurons (PubMed:16481400). Isoform a: Expressed in thermosensory ADF neurons, chemosensory ASE, AWA and AWC neurons, osmosensory ASH neurons and AIY and AIZ interneurons (PubMed:11879652). Expressed in body wall, vulva and pharyngeal muscles (PubMed:11879652).
messages: Forms a complex composed of a calmodulin-dependent catalytic subunit tax-6 (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit cnb-1 (also known as calcineurin B) (PubMed:12221132). In response to an increase in Ca(2+) intracellular levels, forms a complex composed of tax-6, cnb-1 and cmd-1/calmodulin (By similarity). Interacts with cmd-1/calmodulin in a Ca(2+)-dependent manner (PubMed:17854888). Interacts (via catalytic domain) with rcan-1; the interaction is calcium-dependent and inhibits tax-6 catalytic activity (PubMed:12684004, PubMed:26232604). Interacts with exp-1; the interaction is calcium and cnb-1-independent (PubMed:16084527). Interacts with arrd-17 (PubMed:22300764). Interacts with kin-29 (PubMed:17113567). Interacts with cnp-2 (PubMed:18593529). Interacts with daf-16 (PubMed:23805378). Interacts with dyn-1 (PubMed:20803083).
messages: Perikaryon
messages: Possible isomerization of Pro-334 within the SAPNY motif triggers a conformation switch which affects the organization and thus accessibility of the active site and the substrate binding region (PxIxIF motif). The trans- to cis-transition may favor calcineurin A activation and substrate binding. The reverse cis- to trans-transition may be enhanced by peptidyl-prolyl isomerases such as PPIA.
messages: Shorter body length and reduced serotinin-induced egg laying as compared to wild-type (PubMed:27871170). Reduced calcium responses in AFD neurons upon a temperature increase from 16 to 20 degrees Celsius as compared to wild-type. At 17 degrees Celsius displays thermophilic behavior, preferentially migrating towards hotter regions (PubMed:26232604). RNAi-mediated knockdown results in an increase in lifespan (PubMed:21331044, PubMed:23805378). Also causes nuclear exclusion of crtc-1 (PubMed:21331044).
messages: The autoinhibitory domain prevents access to the catalytic site.
messages: The autoinhibitory segment prevents access to the substrate binding site.
messages: axon
messages: cilium
messages: dendrite

6239:CELE B0304.7
gene id: 6239:CELE_B0304.7
uniprot id: Q10936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C55A6.7
gene id: 6239:CELE_C55A6.7
uniprot id: P90781
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE M01E11.2
gene id: 6239:CELE_M01E11.2
uniprot id: P91401
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F13H8.3
gene id: 6239:CELE_F13H8.3
uniprot id: Q19431
names: Similarity
messages: Belongs to the IUNH family.

6239:CELE H38K22.2
gene id: 6239:CELE_H38K22.2
uniprot id: Q9U3C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the cullin cul-3. Interacts with ubiquitin via its UBA-like domain. Interacts with ned-8/nedd8.
messages: Nucleus
messages: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.

6239:CELE H19N07.1
gene id: 6239:CELE_H19N07.1
uniprot id: O45622
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

6239:CELE F08H9.8
gene id: 6239:CELE_F08H9.8
uniprot id: Q19226
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE D1007.6
gene id: 6239:CELE_D1007.6
uniprot id: O01869
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

6239:CELE C17C3.1
gene id: 6239:CELE_C17C3.1
uniprot id: B0M0L9
uniprot id: H2KYT6
uniprot id: Q9BIA9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE K07D4.3
gene id: 6239:CELE_K07D4.3
uniprot id: O76577
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M67A family. PSMD14 subfamily.
messages: Component of the 19S regulatory cap of the 26S proteasome.
messages: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

6239:CELE F20B6.2
gene id: 6239:CELE_F20B6.2
uniprot id: Q19626
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Expressed in embryos, larvae and adults (PubMed:22426883). In embryos, expression begins at the end of gastrulation after the first cell cleavage (PubMed:22426883).
messages: Expressed ubiquitously (PubMed:22426883). Highly expressed in the H-shaped excretory cell, the excretory pore, the intestine, and hypodermal cells (PubMed:22426883). Expressed in the nervous system (PubMed:22426883). Expressed at low levels in muscles (PubMed:22426883).
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (Probable). Essential for the proper assembly and activity of V-ATPase (By similarity). Required maternally for early embryogenesis and zygotically during morphogenesis (PubMed:22426883). Specifically, involved in the clearance of apoptotic cell corpses in embryos (PubMed:22426883). Also, during embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168). In neurons, required for necrotic cell death by promoting intracellular acidification (PubMed:16005300). Required for cell death induced by hypoxia (PubMed:16005300). Required for acidification of synaptic vesicles and the release of neurotransmitters from adult neurons (PubMed:22426883).
messages: RNAi-mediated knockdown causes hyperfusion of embryonic epidermal cells (PubMed:15866168). RNAi-mediated knockdown suppresses hypoxia-induced cell death, and, in a mec-4 (u231) mutant background, neurodegeneration of touch-receptor neurons (PubMed:16005300).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE ZK507.1
gene id: 6239:CELE_ZK507.1
uniprot id: P34633
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

6239:CELE T09B4.1
gene id: 6239:CELE_T09B4.1
uniprot id: O02164
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis (By similarity). Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). Required for maintenance of epithelial integrity during embryogenesis (PubMed:25807459).
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Expressed in epithelial tissues including the epidermis, pharynx, intestine, rectum and excretory cell during embryogenesis.

6239:CELE F10G8.3
gene id: 6239:CELE_F10G8.3
uniprot id: Q93454
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat rae1 family.
messages: Expressed along the ventral and dorsal nerve cords.
messages: Functions as a component of the nuclear pore complex (NPC) (PubMed:12937276). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export (PubMed:12937276). Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons (PubMed:22357847).
messages: Nucleus
messages: Synapse
messages: The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport (By similarity). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope (By similarity). Interacts with rpm-1 (PubMed:22357847).
messages: axon
messages: nuclear pore complex

6239:CELE Y54G9A.4
gene id: 6239:CELE_Y54G9A.4
uniprot id: Q9XWH3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M106.3
gene id: 6239:CELE_M106.3
uniprot id: Q0G839
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

6239:CELE C43E11.8
gene id: 6239:CELE_C43E11.8
uniprot id: P91149
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Involved in ER-Golgi transport.

6239:CELE ZK721.1
gene id: 6239:CELE_ZK721.1
uniprot id: Q9GYF0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SID1 family.
messages: Cell membrane
messages: Cholesterol-binding protein which is involved in dietary cholesterol uptake from the environment (PubMed:22479487). Does not play a role in double-stranded RNA transport in contrast to other SID1 family members (PubMed:29025917, PubMed:18201385).
messages: Expressed in the embryo, larva and adult with no difference in expression level across larval stages and adult.
messages: Highly expressed along the intestine with expression also detected in the pharynx, especially at the terminal bulb, and in the excretory gland cells.
messages: Hypersensitivity to cholesterol availability and decreased cholesterol uptake (PubMed:22479487). When grown in low cholesterol conditions, 72% reduction in offspring number compared to 25% reduction in wild-type worms, 60% reduction in oocyte number, altered oocyte distribution in 47% of mutants, and 5-fold increase in embryonic lethality (PubMed:22479487). In addition, in low cholesterol conditions, growth of mutants ceases by day 3, resulting in a 63% reduction in adult size at day 5, there is a 22% reduction in the number of L1 larvae that reach adulthood and a 4-5 hour delay in the L4-to-adult transition (PubMed:22479487). 78% reduction in dauer formation, increased sensitivity of adult hermaphrodites to heat exposure and reduced speed of movement independent of cholesterol availability (PubMed:22479487). Mutants show a twitching phenotype upon administration of unc-22 feeding RNAi, indicating a lack of involvement in the systemic RNAi response (PubMed:18201385). RNAi-mediated knockdown results in decreased cholesterol uptake and, when grown in low-cholesterol conditions, altered oocyte distribution in 42% of mutants, reduced oocyte numbers and reduced speed (PubMed:22479487).
messages: Probable cloning artifact.

6239:CELE Y57G7A.10
gene id: 6239:CELE_Y57G7A.10
uniprot id: O76630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

6239:CELE C25H3.3
gene id: 6239:CELE_C25H3.3
uniprot id: Q18187
names: Similarity
messages: Belongs to the thioesterase PaaI family.

6239:CELE C10H11.8
gene id: 6239:CELE_C10H11.8
uniprot id: E5QCF5
uniprot id: P91040
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of TORC1 complex. Part of the TORC2 complex.
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.

6239:CELE T20D4.6
gene id: 6239:CELE_T20D4.6
uniprot id: P91469
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y69A2AR.4
gene id: 6239:CELE_Y69A2AR.4
uniprot id: Q95XG8
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the NRAMP family.
messages: Cytoplasmic vesicle membrane
messages: Expressed in dopaminergic neurons (at protein level) (PubMed:23106139). Expressed in intestine with a weaker expression in the most proximal and distal regions (PubMed:19785996, PubMed:19924247). Weakly expressed in the hyp1-6, hyp7 and hyp8-12 hypodermis and in head and tail neurons (PubMed:19924247).
messages: Increased survival rate and reduced body levels of iron in response to increasing Mn(2+) levels (PubMed:19924247). Reduced survival rate in response to high Mn(2+) levels or to infection mediated by pathogenic bacterium S.aureus (PubMed:19785996). Reduced CEP neuron death and higher Al(3+) accumulation in the body in response to high Al(3+) levels (PubMed:23106139). Reduced ferritin ftn-1 mRNA levels and Mn(2+) and iron body levels (PubMed:22194696). Increased sfm-1, sfm-2 and sfm-3 mRNA levels (PubMed:19924247).
messages: Induced by pathogenic bacterium S.aureus (PubMed:19785996). Repressed by high levels of Mn(2+) (PubMed:19924247). Repressed by high levels of Al(3+) (PubMed:23106139). Induced by low iron levels (PubMed:22194696).
messages: Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron (PubMed:19924247, PubMed:23106139, PubMed:19785996, PubMed:22194696). Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+) (PubMed:23106139).

6239:CELE K10B4.6
gene id: 6239:CELE_K10B4.6
uniprot id: P34888
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cell membrane
messages: Cytoplasm
messages: Defective ALM, BDU and QR neuroblast migration and irregular HSN and CP axon growth and guidance (PubMed:16109397). Double knockout with cwn-2 results in ALM and CAN migration defects (PubMed:16109397). Double knockout with either cwn-2 or egl-20 results in HSN migration defects (PubMed:16516839). Triple knockout with cwn-2 and cfz-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). First expressed in the embryonic tail at the comma stage of embryogenesis (PubMed:16516839). In newly hatched larvae, it is expressed in four stripes of cells lining the dorsal and ventral posterior quadrants of the body (PubMed:16516839). Expression spreads anteriorly becoming restricted to the ventral side of the body as development progresses (PubMed:16516839).
messages: Expressed in intestine, some head neurons and ventral nerve cord and pharyngeal neurons (PubMed:19561603). Expressed in the tail and weakly expressed in the vulva and body wall muscles (PubMed:20711352). Expressed highly in posterior dorsal and ventral muscle cells (PubMed:22022276).
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1 (PubMed:17942487). Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). Also acts with the Wnt ligand egl-20 to direct HSN neuron migration (PubMed:16516839). Acts through the Wnt receptor cfz-2 to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Probably by activating the Wnt/Frizzled pathway, may regulate vulva development (PubMed:17942487). May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity (PubMed:22022276).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE C07G3.9
gene id: 6239:CELE_C07G3.9
uniprot id: A0A131MBT3
uniprot id: O16322
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F34D10.5
gene id: 6239:CELE_F34D10.5
uniprot id: G5EDU6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Differences in the regulation of lin-48 expression may explain, at least in part, differences in excretory duct morphology and function between C.elegans and the related species C.briggsae.
messages: Expressed in late embryogenesis and into adulthood (PubMed:11532910, PubMed:16310763). Expression in the excretory duct cell begins in the majority of embryos by comma stage and persists throughout larval development into adulthood (PubMed:16310763). Expressed in L1 stage larvae in the excretory duct cell, neuronal support cells of the phasmid and labial sensory structures and a small number of additional unidentified cells in the head (PubMed:11532910, PubMed:12231624).
messages: Nucleus
messages: Transcription factor (By similarity). Involved in development of the hindgut, the male tail, and the excretory duct cell (PubMed:10511553, PubMed:11532910, PubMed:12231624). Involved in modulating function of excretory duct cells (PubMed:14758362). Plays a role in left/right patterning of cell fates in the hindgut (PubMed:10511553, PubMed:11532910).

6239:CELE F18A1.2
gene id: 6239:CELE_F18A1.2
uniprot id: Q27355
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in somatic gonads and germline precursors until the 50-cell stage. After the 100-cell stage, expression is seen in differentiating hypodermal and support cells (at protein level).
messages: Expressed throughout development from embryos to adults.
messages: Nucleus
messages: Probable transcription factor (PubMed:7956818, PubMed:24885717). Required to specify the fates of hypodermal and neuron-associated support cells (PubMed:7956818). Functions during vulval development, playing a role in vulval precursor cell fate specification (PubMed:11063687, PubMed:24885717). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:30921322). This is rescued by RNAi-mediated knockdown of rsd-6, and nrde-2 (PubMed:30921322). RNAi-mediated knockdown at the larval L1 stage causes a weak but significant decrease in expression of lin-39 (PubMed:24885717). Knockdown in mothers caused lower levels of lin-39 expression in the P blastomere of embryos (PubMed:24885717). Knockdown in L1 stage larvae, in a lin-39 mutant background, causes abnormal fusion of vulval precursor cells at larval stage L2 (PubMed:24885717).

6239:CELE C41G6.8
gene id: 6239:CELE_C41G6.8
uniprot id: G3MU49
uniprot id: G3MU50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y26D4A.12
gene id: 6239:CELE_Y26D4A.12
uniprot id: Q7YWT3
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F44E2.4
gene id: 6239:CELE_F44E2.4
uniprot id: P34434
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05B4.6
gene id: 6239:CELE_T05B4.6
uniprot id: O16416
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C07D10.3
gene id: 6239:CELE_C07D10.3
uniprot id: Q17781
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C01A2.3
gene id: 6239:CELE_C01A2.3
uniprot id: O02207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

6239:CELE F54F2.8
gene id: 6239:CELE_F54F2.8
uniprot id: P34453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-19 family.
messages: Peroxisome

6239:CELE W03F9.5
gene id: 6239:CELE_W03F9.5
uniprot id: O16991
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with TFIID-TFIIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by RNA polymerase II.
messages: Belongs to the TFIIB family.
messages: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II) (By similarity). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (By similarity). Essential for early embryonic development (PubMed:11566890).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced severely in embryos (PubMed:11566890).

6239:CELE F23F1.1
gene id: 6239:CELE_F23F1.1
uniprot id: O17072
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NFYC/HAP5 subunit family.
messages: Component of sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y and nfya-2-NF-Y) complexes which specifically recognize a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the NF-Y complexes, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492). May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (Probable). In association with the components in the nfya-1-NF-Y complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head (PubMed:17574230). May regulate egl-5 expression in association with the mes-2-mes-3-mes-6 complex (PubMed:17574230).
messages: Cytoplasm
messages: Expressed in cells of the developing embryo (PubMed:15704008, PubMed:17574230). At the larval stages, weakly expressed in neurons and pharyngeal secretory cells (PubMed:15704008, PubMed:17574230). At larval stages also expressed in the developing hermaphrodite vulva and male tail (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008).
messages: Expressed in certain parts of the gonads with high expression in fertilized oocytes in the uterus and mature oocytes from the distal to the proximal arm of the gonad, but weak expression in the syncytial ovaries and immature oocytes at the beginning of the proximal arm of the gonad (PubMed:15704008). Expressed in the excretory cell, secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008). Not expressed in the intestine, the hypodermis or body wall muscle surrounding the pseudocoelomic space (PubMed:15704008).
messages: Forms two NF-Y heterotrimeric transcription factor complexes: the nfya-1-NF-Y complex is composed of nfya-1, nfyb-1 and nfyc-1, and the nfya-2-NF-Y complex is composed of nfya-2, nfyb-1 and nfyc-1 (PubMed:17574230). Interacts with nfyb-1; the interaction is direct and is required for the interaction with either nfya-1 or nfya-2, and subsequent binding of the complex to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230).
messages: Nucleus
messages: Perikaryon
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). RNAi-mediated knockdown results in ectopic expression of tbx-2 in the gut and seam cells of L4 stage larvae and adults (PubMed:23933492).

6239:CELE C18F10.8
gene id: 6239:CELE_C18F10.8
uniprot id: P54129
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F08F8.2
gene id: 6239:CELE_F08F8.2
uniprot id: Q19207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane

6239:CELE K04G11.4
gene id: 6239:CELE_K04G11.4
uniprot id: Q93847
names: Disruption Phenotype
names: Function
messages: No obvious phenotype at 20 degrees Celsius or 25 degrees Celsius. At 20 and 25 degrees Celsius, double knockdown mutants with wdr-5.1 have increased fog-3 expression. At 25 degrees Celsius, these mutants have increased fog-1 expression, reduced brood size accompanied by 42% embryonic lethality with 100% of the surviving progeny being sterile. Surviving progeny display defective spermatogenesis to oogenesis transition with 88% of the gonads only containing sperm. The remaining germ cells in the gonads switch to oogenesis, but the oocytes display either an endoreplication or endomitotic phenotype. Germ cells also have increased expression of the sex determining factor tra-1 in the cytoplasm and as a result there is reduced binding of tra-1 to the fog-3 promoter. No detectable defects in histone H3 'Lys-4' di- or tri-methylation in embryos or adults germ cells at 20 or 25 degrees Celsius.
messages: Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'.

6239:CELE Y23H5B.6
gene id: 6239:CELE_Y23H5B.6
uniprot id: Q9N478
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

6239:CELE Y47D7A.14
gene id: 6239:CELE_Y47D7A.14
uniprot id: A0A168HBC9
uniprot id: A0A168HBE9
uniprot id: G4SDH4
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Down-regulated by high levels of riboflavin.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in intestine and pharynx.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
messages: RNAi-mediated knockdown causes a severe reduction in the number of laid eggs.
messages: Riboflavin transporter.

6239:CELE R05H10.6
gene id: 6239:CELE_R05H10.6
uniprot id: O62328
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C33A12.15
gene id: 6239:CELE_C33A12.15
uniprot id: O17635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE W01G7.3
gene id: 6239:CELE_W01G7.3
uniprot id: Q9XVH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
messages: Nucleus

6239:CELE T18D3.7
gene id: 6239:CELE_T18D3.7
uniprot id: Q22544
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

6239:CELE F09C6.8
gene id: 6239:CELE_F09C6.8
uniprot id: O45328
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C46H11.3
gene id: 6239:CELE_C46H11.3
uniprot id: P91167
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

6239:CELE ZC434.8
gene id: 6239:CELE_ZC434.8
uniprot id: Q27535
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

6239:CELE R10D12.6
gene id: 6239:CELE_R10D12.6
uniprot id: P92009
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE Y53F4B.2
gene id: 6239:CELE_Y53F4B.2
uniprot id: Q9NAC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

6239:CELE Y17G7B.15
gene id: 6239:CELE_Y17G7B.15
uniprot id: Q9XXH8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Causes a delay in cell death during embryogenesis characterized by a decrease in the number of cell corpses at the comma and 1,5 fold stage and an increase in the number of cell corpses between the 2-fold and the 3-fold stages.
messages: Cell membrane
messages: Cleaved by caspase ced-3 after Asp-382 and Asp-609. Cleavage at Asp-382 is required for subsequent cleavage at Asp-609.
messages: Cytoplasm
messages: Expressed in embryos.
messages: GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6 (PubMed:22869721).
messages: Interacts (via C-terminal ankyrin repeat) with rab-10 (GTP-bound form); the interaction is required for cnt-1 recruitment to endosomes. Interacts (via C-terminal ankyrin repeat) with rab-8 (GTP-bound form) and rab-35 (GTP-bound form).
messages: Recycling endosome membrane
messages: The PH domain binds phosphatidylinositol phosphate (PIP), phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), and to a lesser extent phosphatidic acid and cardiolipin.
messages: Truncated cnt-1: Promotes apoptosis during embryonic development. Produced by caspase ced-3-mediated cleavage, and translocates to the plasma membrane where it prevents the activation of the prosurvival Akt-1/2 and sgk-1 signaling pathway by competing with Akt-1/2 for the binding to PtdIns(3,4,5)P3.

6239:CELE C35A11.1
gene id: 6239:CELE_C35A11.1
uniprot id: O16548
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK1128.6
gene id: 6239:CELE_ZK1128.6
uniprot id: Q09647
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in embryos and adults.
messages: Expressed in many sensory neurons in amphid.
messages: Monoglutamylase which modifies tubulin, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:32747782). Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin (PubMed:32747782). Involved in side-chain glutamylation of tubulin in sensory cilia (PubMed:20519502, PubMed:27635036, PubMed:29849065). Together with ttll-5 and ttll-11, required for male mating (PubMed:27635036).
messages: RNAi-mediated knockdown at the L1 or L4 larval stages causes a defect in egg-laying.

6239:CELE W02G9.4
gene id: 6239:CELE_W02G9.4
uniprot id: A0A0M7RE06
uniprot id: O61901
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55A11.5
gene id: 6239:CELE_F55A11.5
uniprot id: Q20800
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acyltransferase required for the fatty acid remodeling of phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI). Mediates the conversion of lysophosphatidylinositol (2-acylglycerophosphatidylinositol or LPI) into PI (LPIAT activity). Has preference for saturated and mono-unsaturated fatty acids as acyl donors and sn-2-acyl lysoPI (2-acyl-sn-glycero-3-phospho-D-myo-inositol) as acyl acceptor. Contributes to the asymmetric cell division of epithelial cells. Asymmetric cell division is the fundamental mechanism by which multicellular organisms generate cell diversity.
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed in seam cells, vulval epithelial cells and the major epithelial syncytium hyp7, and in several head neurons including AIY interneurons.
messages: Mutants showed defects in vulval morphology and in the asymmetric division of stem cell-like epithelial cells.

6239:CELE C38D4.6
gene id: 6239:CELE_C38D4.6
uniprot id: P34766
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Caudal homeobox family.
messages: Blastomeres. Embryo. Oocytes.
messages: By heat shock.
messages: Chromosome
messages: Embryos shows disorganization of cell types and lack specification. Loss of V6 rays development in male tail. C and D blastomere derived muscle.
messages: Expressed both maternally and zygotically. Expression observed at the 4 cell embryo in posterior blastomeres. Detected in all descendants of EMS and P2 blastomeres. During gastrulation and morphogenesis expression is seen sporadically in all major cell lineages except the germ line.
messages: Fifth intron is thought to contain a regulatory element required for expression in postembryonic neuroblast V6 cells. 3'-UTR thought to inhibit self-translation in anterior blastomeres.
messages: Interacts with tir-1 and let-756.
messages: Nucleus
messages: Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death. Has a role in E cell specification in endoderm development and body wall muscle development.
messages: kinetochore

6239:CELE Y38E10A.5
gene id: 6239:CELE_Y38E10A.5
uniprot id: Q9NAK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F56A3.2
gene id: 6239:CELE_F56A3.2
uniprot id: P91351
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Both the N- and C-terminal regions are required for interaction with him-18.
messages: Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures (PubMed:22927825). Required for proper crossover distribution through inhibition of crossover formation at the central region of chromosomes (PubMed:22927825, PubMed:23874210).
messages: Forms a heterodimer with him-18/slx-4.
messages: Nucleus
messages: Reduced brood size, increased embryonic lethality and increased larval arrest (PubMed:22927825, PubMed:23874210). Increased number of rad51 foci in meitotic and mitotic nuclei and increased germ cell apoptosis (PubMed:22927825). Hypersensitivity to ultraviolet C, nitrogen mustard and camptothecin but not to gamma irradiation (PubMed:22927825). Increased chromosomal abnormalities including increased intra- and inter-bivalent chromatin bridges (PubMed:23874210). Increased meiotic crossover frequency in the center of chromosomes III, IV, V and X with decreased frequency in the arm regions of chromosomes III, IV, V and X (PubMed:22927825).

6239:CELE Y18D10A.9
gene id: 6239:CELE_Y18D10A.9
uniprot id: Q9XW12
names: Function
names: Similarity
messages: Belongs to the WD repeat CIA1 family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

6239:CELE Y87G2A.11
gene id: 6239:CELE_Y87G2A.11
uniprot id: Q9U1Q0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat EIPR1 family.
messages: Cytoplasm
messages: Defective egg-laying and slow, but coordinated locomotion when stimulated. Reduced levels of both unprocessed and processed luminal and transmembrane cargo in the motor neuron axons of the dorsal nerve cord. Double knockout with either rab-2, rund-1 or vps-50 results in reduced levels of both unprocessed and processed luminal and transmembrane cargo in the motor neuron axons of the dorsal nerve cord.
messages: Expressed in the hypodermis and the pharynx.
messages: Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex. Important for neuronal function.
messages: The subcellular location of endogenous eipr-1 could not be identified; diffuse expression of a eipr-1 construct in the cytoplasm may be an artifact due to over-expression of the construct.

6239:CELE T23B3.4
gene id: 6239:CELE_T23B3.4
uniprot id: P91487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE F08F8.7
gene id: 6239:CELE_F08F8.7
uniprot id: Q95ZW2
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

6239:CELE F40E10.4
gene id: 6239:CELE_F40E10.4
uniprot id: G5EFX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development.
messages: Interacts with eva-1.
messages: Secreted

6239:CELE F55A8.2
gene id: 6239:CELE_F55A8.2
uniprot id: O76360
uniprot id: U4PEQ9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Binding of cGMP results in enzyme activation.
messages: Cytoplasm
messages: Expressed in AWC sensory neurons (at protein level) (PubMed:20220099). Mainly expressed in head neurons, hypodermis, intestine and body wall muscles. L2 and L3 larvae show extensive expression, lower levels are observed in L4 larvae, later embryos and adults. Isoform c is expressed in a subset of neurons in the head, nerve ring, and ventral nerve cord including some motor neurons, also in several neurons in the tail, the pharyngeal marginal cells, body muscle, intestine, vulval muscles, and spermatheca (PubMed:11181837, PubMed:12571101, PubMed:15330854).
messages: Increased size and extended lifespan (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Defects in chemosensory behavior, egg-laying, synaptic transmission, and dauer formation (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Impaired movement of adult animals in response to sensory stimuli (PubMed:10978280). Loss of adaptive behavior to long lasting exposure to attractive odorants (PubMed:20220099). Normal initial chemotaxis response during a first and short exposure to attractive odorants (PubMed:20220099). Loss of chemotaxis response to the repellent odor 2-nonanone (PubMed:23954825). Defective chemotaxis in response to diacetyl and isoamylalcohol (PubMed:26434723). High sensitivity to benzaldehyde, which is retained following pre-exposure in contrast to wild-type animals (PubMed:26434723). Increased basal cGMP levels (PubMed:24015261).
messages: Nucleus
messages: Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor (PubMed:18832350). Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2 (PubMed:21573134). Represses body size and lifespan through the dbl-1 and insulin pathways, respectively (PubMed:12571101, PubMed:15330854, PubMed:26434723). May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility (PubMed:12571101, PubMed:11181837, PubMed:21573134). Regulates behavioral responses to various chemosensory stimuli in sensory neurons (PubMed:10978280, PubMed:22319638, PubMed:23874221, PubMed:26434723). Required for the initiation of long term adaptation to prolonged odor exposure which results in a decrease in odor seeking behavior (PubMed:12495623, PubMed:20220099, PubMed:26434723). May regulate this process by phosphorylating tax-2, a subunit of cyclic nucleotide-gated channel tax-2/tax-4 (PubMed:12495623). In ASH sensory neurons, negatively regulates avoidance behavior to some bitter tastants, such as quinine, probably by phosphorylating rgs-2 and rgs-3 which are 2 regulator of G-protein signaling proteins (PubMed:23874221). In AWB sensory neurons, involved in avoidance behavior to some repellent odors (PubMed:23954825). In ASE left (ASEL) sensory neuron, involved in the sensing of environmental alkalinity downstream of receptor-type guanylate cyclase gcy-14 (PubMed:23664973). In sensory neurons, involved in the signaling pathway downstream of insulin, TGF-beta and receptor-type guanylate cyclase responsible for inducing quiescence after food intake (PubMed:18316030). Might play a role in aversive olfactory learning in AWC neurons when an odor is associated with food deprivation, depending on the ins-1/age-1 signal from the AIA to the AWC neurons (PubMed:27383131). Probably by regulating neuronal transmiss…
messages: When phosphorylated, interacts with saeg-2. May interact with saeg-1.

6239:CELE R07E5.2
gene id: 6239:CELE_R07E5.2
uniprot id: Q21824
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Homodimer; disulfide-linked, upon oxidation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

6239:CELE F56H9.5
gene id: 6239:CELE_F56H9.5
uniprot id: Q10573
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in all stages but highest during L1, L2 and L3 stages (at protein level).
messages: Expressed in seam cells and all six vulva precursor cells (VPC). After VPC division, expression is restricted to descendants of the VPC cell lineages P5.p, P6.p and P7.p (at protein level).
messages: Nucleus
messages: Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types (PubMed:11063686). Positively regulates the fate of vulval precursor cells (PubMed:3996896, PubMed:7867931, PubMed:9806929). Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene (PubMed:11063686). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855).

6239:CELE C35D10.15
gene id: 6239:CELE_C35D10.15
uniprot id: Q95QR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F07B7.5
gene id: 6239:CELE_F07B7.5
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE F15E6.2
gene id: 6239:CELE_F15E6.2
uniprot id: I2HA93
uniprot id: O44497
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C56G2.1
gene id: 6239:CELE_C56G2.1
uniprot id: Q09285
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48C3A.8
gene id: 6239:CELE_Y48C3A.8
uniprot id: B7FAS6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Defects in PLM neuron synaptic differentiation characterized by a misalignment of active zones and synaptic vesicles, branch point anterior to the vulva and overextension of synaptic branch. DD motoneurons display similar pre-synaptic defects. Increased expression of prk-2. In addition, mutants display a moderate uncoordinated movement, a small decrease in body size, a defect in egg laying and a slower growth.
messages: Expression begins at the 1.5-fold embryonic stage and is retained in the adult.
messages: Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning.
messages: Nucleus
messages: Ubiquitously expressed with higher expression in the head and tail ganglia, the vulva and PLM neurons.

6239:CELE C03C10.2
gene id: 6239:CELE_C03C10.2
uniprot id: P42169
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

6239:CELE K04G2.8
gene id: 6239:CELE_K04G2.8
uniprot id: A0A1I6CM53
uniprot id: Q21227
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenomatous polyposis coli (APC) family.
messages: Cytoplasm
messages: During the L1 stage, expressed in vulval precursor cells (P3-8.p), seam cells and excretory cells.
messages: Has a role in endoderm cell specification and pharyngeal development (PubMed:9288750). Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471). During larval development, apr-1 is required for expression of lin-39 in P3-8.p (PubMed:10766743). Shown to negatively regulate Wnt signaling in vulval precursor cells (PubMed:12023306). Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei (PubMed:17276345). During the L4 larval stage, it is required for the asymmetric division and self-renewal of seam cells (PubMed:19607822). Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1 (PubMed:12023307).
messages: Interacts (via N-terminus) with bar-1 and hmp-2; the interaction with hmp-2 is relatively weak. Interacts (via C-terminus) with pry-1 (via N-terminus). Probably associates with bar-1, gsk-3, pry-1 in a complex.
messages: Nucleus
messages: Worms exhibit lack of endoderm, excessive pharyngeal tissue and premature division of the E daughter blastomeres during embryogenesis. Two-thirds arrest during embryogenesis and the remaining third during the L1 stage (PubMed:9288750). RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471).
messages: adherens junction

6239:CELE C18A3.8
gene id: 6239:CELE_C18A3.8
uniprot id: Q09961
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in both symmetric and asymmetric neuronal lineages (PubMed:21698137). In the posterior embryo, expressed in PVQ/HSN/PHB neuroblasts and their descendants (PubMed:14627726, PubMed:21698137). Expressed in the sensory ASE neuron lineage (PubMed:21698137).
messages: Nucleus
messages: Probable transcription factor, involved in determining neuroblast cell fate, morphogenesis and aspects of terminal differentiation in both left/right symmetric and asymmetric neuronal lineages.
messages: RNAi-mediated knockdown disrupts differentiation of ASE L/R sensory neurons.

6239:CELE F01G10.8
gene id: 6239:CELE_F01G10.8
uniprot id: F5GUE5
names: Developmental Stage
names: Function
names: Subunit
messages: Interacts with R-SMAD daf-8 and co-SMAD daf-3 (PubMed:20081192). Interacts with daf-3 in a daf-8 dependent manner (PubMed:20081192).
messages: Probably an atypical receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling (PubMed:10625546). Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-8 (PubMed:10625546, PubMed:20081192).
messages: Widely expressed in all stages from the embryo to the adult in a complex and dynamic pattern (PubMed:10625546). In L1 and L2 stage larvae, expressed in intestinal cells, lateral hypodermal cells, the anal sphincter muscle, phasmid sheath cells, neurons in the lateral ganglia, and the excretory duct cell (PubMed:10625546).

6239:CELE F22D6.12
gene id: 6239:CELE_F22D6.12
uniprot id: G5EBK7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C37F5.1
gene id: 6239:CELE_C37F5.1
uniprot id: G5EDL0
uniprot id: U4PLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

6239:CELE H20J04.4
gene id: 6239:CELE_H20J04.4
uniprot id: Q2WF63
uniprot id: Q9N5M1
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE F53C3.12
gene id: 6239:CELE_F53C3.12
uniprot id: Q9TXT9
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

6239:CELE F54G8.3
gene id: 6239:CELE_F54G8.3
uniprot id: Q03600
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Heterodimer of an alpha and a beta subunit. Alpha ina-1 associates with beta pat-3 (PubMed:9247263). Interacts (via cytoplasmic domain) with src-1 (when phosphorylated at 'Tyr-416') (PubMed:20226672).
messages: Membrane
messages: Plays a role in cell migration, axon fasciculation, and morphogenesis (PubMed:9247263). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419, PubMed:22732572, PubMed:25982859). Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p (PubMed:25373777). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
messages: RNAi-mediated knockdown in distal tip cell (DTC) causes DTC morphological and guidance defects such as precocious dorsal turns, a failure to reach the vulva and a bloated distal gonad (PubMed:19023419). Embryos at the comma, 1.5-fold and 2-fold stages have increased number of cell corpses due to a defect in cell engulfment (PubMed:20226672). RNAi-mediated knockdown with mig-38 results in enhanced gonad DTC migration (PubMed:22732572).
messages: phagocytic cup
messages: phagosome membrane

6239:CELE R05D3.4
gene id: 6239:CELE_R05D3.4
uniprot id: P34537
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity). H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity). Involved in regulating stem cell proliferative fate (PubMed:25564623).
messages: Expressed at all life stages.
messages: In adult animals, expressed in oocytes, germ cells, pharyngeal and intestinal cells.
messages: Interacts with ubc-1 (PubMed:14732404). Interacts with mrg-1 (PubMed:25564623).
messages: Nucleus
messages: Worms arrest their development at L1 stage, and show tail abnormalities (PubMed:14732404). RNAi-mediated knockdown on a glp-1 mutant background causes significant overproliferation of germline cells (PubMed:25564623).

6239:CELE M01E5.3
gene id: 6239:CELE_M01E5.3
uniprot id: A5JYZ1
uniprot id: A5JYZ2
uniprot id: O45692
names: Similarity
messages: Belongs to the UPF0561 family.

6239:CELE Y40B1B.8
gene id: 6239:CELE_Y40B1B.8
uniprot id: Q9U2J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

6239:CELE T19A6.4
gene id: 6239:CELE_T19A6.4
uniprot id: Q95QA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE C07E3.1
gene id: 6239:CELE_C07E3.1
uniprot id: Q17784
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TFP11/STIP family.
messages: Detected in muscle cells from body, pharynx and vulva, in neurons from head and tail, in pharyngeal gland and in tail hypodermal cells.
messages: Detected in oocyte, embryo, larval stage 1 to 4, and in adult.
messages: Identified in the spliceosome C complex (By similarity). Can assemble into large rod-like polymers.
messages: May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival.
messages: Nucleus

6239:CELE F57B10.11
gene id: 6239:CELE_F57B10.11
uniprot id: O44739
names: Domain
names: Function
names: Subunit
messages: Homodimer or homotetramer.
messages: May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.
messages: The BAG domain probably mediates direct interaction with HSP70.

6239:CELE F58G11.4
gene id: 6239:CELE_F58G11.4
uniprot id: D9N145
uniprot id: Q9XVL9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C25A1.6
gene id: 6239:CELE_C25A1.6
uniprot id: Q9XVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP10 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE C18E3.7
gene id: 6239:CELE_C18E3.7
uniprot id: Q86NJ8
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE Y37D8A.9
gene id: 6239:CELE_Y37D8A.9
uniprot id: A7DTF0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Interacts with cfp-1, a component of the SET2 complex (PubMed:31602465). Interacts with rfp-1 (PubMed:25564623).
messages: Expressed in embryos, L1 larvae and adult hermaphrodites and decreases drastically between the L2 and L4 larval stages (at protein level) (PubMed:12175490, PubMed:17215300). In late embryos and young larvae, expressed at higher levels in the two primordial germ cells (PGCs), Z2 and Z3, than in somatic blastomeres (PubMed:17215300, PubMed:30929290). Expressed at a relatively constant level throughout the distal end of the gonad at the L1 stage, with no decrease as cells enter into meiotic prophase (PubMed:25564623).
messages: Expressed in oocytes (at protein level) (PubMed:12175490). Expressed mainly in germ cells, but also at lower levels in several somatic cell types, including intestinal cells (PubMed:17215300).
messages: Maternal-effect lethality and sterility (PubMed:17215300). Primordial germ cells (PGCs) do not proliferate normally and death of germ cells may be as a result of necrosis or increased apoptosis (PubMed:17215300, PubMed:22212480). Increased proportion of oocytes with fragmented chromosomes as a result of irradiation (PubMed:22212480). Tumorous germline phenotype that is suppressed on a rfp-1;glp-1 double mutant background (PubMed:25564623). Germline progression from leptotene/zygotene to pachytene is defective (PubMed:22212480). Perinuclear anchoring of heterochromatin in intestinal or hypodermal cells is disrupted and exacerbated on a cec-4 mutant background, but is partially blocked by RNAi-mediated knockdown of cbp-1 or atf-8 (PubMed:31118512). RNAi-mediated knockdown causes defective homologous chromosome pairing, complete absence of the germline in almost all adult F1 progeny and slight underdevelopment of the somatic gonad (PubMed:12175490, PubMed:22172672). RNAi-mediated knockdown strongly blocks mitosis of PGCs at early larval stages, and the arrested PGCs may degenerate during late larval stages (PubMed:12175490). RNAi-mediated knockdown induces germ cells to undergo conversion into neuron-like cells (PubMed:30425042). RNAi-mediated knockdown causes a slight increase in levels of the constitutive heterochromatin mark, trimethylated histone H3 'Lys-9' (H3K9me3), and an increase of acetylated histone H3 'Lys-14' (H3K14ac) (PubMed:30425042). Simultaneous RNAi-mediated knockdown of mep-1 suppresses the ectopic expression of pgl-1 protein and the overexpression of pgl-1 mRNA in larvae (PubMed:17215300). RNAi-mediated knockdown induces germ cell apoptosis; however, on clk-2 or cep-1 mutant backgrounds apoptosis is reduced substantially (PubMed:22212480).
messages: Nucleus
messages: Protein involved in the remodeling of chromatin thereby regulating various processes including transcription, chromosome synapsis and genome integrity (PubMed:22172672, PubMed:22212480, PubMed:17215300, PubMed:30929290). Mainly binds genomic loci carrying trimethylated histone H3 'Lys-36' (H3K36me3) or 'Lys-4' (H3K4me3), and acetylated histone H3 'Lys-9' (H3K9ac), 'Lys-27' (H3K27ac) (PubMed:30425042, PubMed:31118512). During meiosis, required for the presynaptic pairing of homologous chromosomal regions outside of the pairing center and for the progression of chromosome synapsis (PubMed:22172672, PubMed:22212480). Essential maternal factor required in postembryonic germline development and in maintaining germ cell identity (PubMed:12175490, PubMed:30425042). Plays an important role in maintaining genomic integrity in primordial germ cells (PGCs) during meiosis by regulating DNA double-strand break (DSB) repair and synapsis (PubMed:22212480, PubMed:30929290). Also, required for chromatin-based transcriptional silencing in PGCs and for silencing of X-linked genes in the maternal germ line (PubMed:17215300, PubMed:30929290). By retaining histone acetyltransferase, cbp-1, in euchromatin, promotes the anchoring of heterochromatin at the inner nuclear membrane in intestinal and hypodermal cells (PubMed:31118512).

6239:CELE T25D10.1
gene id: 6239:CELE_T25D10.1
uniprot id: Q10017
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08D12.1
gene id: 6239:CELE_F08D12.1
uniprot id: P91240
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of srpa-68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with srpa-68 (By similarity). Srpa-68-srpa-72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via N-terminus) with srpa-68 (via C-terminus) (By similarity).

6239:CELE Y87G2A.10
gene id: 6239:CELE_Y87G2A.10
uniprot id: Q9NA26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
messages: Endosome
messages: Expressed in embryos.

6239:CELE Y46G5A.17
gene id: 6239:CELE_Y46G5A.17
uniprot id: Q9U2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

6239:CELE ZK593.7
gene id: 6239:CELE_ZK593.7
uniprot id: Q23543
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

6239:CELE T19D12.8
gene id: 6239:CELE_T19D12.8
uniprot id: Q22576
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y56A3A.13
gene id: 6239:CELE_Y56A3A.13
uniprot id: O76463
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP.
messages: Expressed in adult.
messages: Homotetramer.
messages: In the N-terminal section; belongs to the UPF0012 family.

6239:CELE F38C2.2
gene id: 6239:CELE_F38C2.2
uniprot id: O45489
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryos and during larval development (PubMed:16014321). Expressed strongly in cephalic sheath (CEPsh) glia at all developmental stages and in some motoneurons of the ventral cord in larvae (PubMed:18508862).
messages: Expressed in neuronal tissues of the head, including sheath cells of the cephalic sensilla (CEPsh) glia.
messages: Expression in ventral CEPsh glia is normal in knockout, but significantly reduced on a vab-3(ns157) mutant background (PubMed:18508862). RNAi-mediated knockdown causes egg-laying defects (PubMed:16014321).
messages: Nucleus
messages: Probable transcription factor that regulates the expression of dopamine receptors dop-1, dop-2 and dop-3 and thus dopamine-dependent behaviors (PubMed:18508862, PubMed:21688290). May act redundantly with hlh-31 and hlh-32 to regulate ventral CEPsh glia functions (PubMed:18508862). May play a role in chemotactic responses in larvae (PubMed:16014321, PubMed:21688290).

6239:CELE F25D7.3
gene id: 6239:CELE_F25D7.3
uniprot id: Q93560
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in hypodermal, vulval, intestinal and distal tip cells.
messages: Gonadal migration defects with premature dorsal turning of distal tip cells in the hermaphrodite gonad (PubMed:24613396, PubMed:24968003). Defective dauer formation, shortened lifespan and retarded terminal differentiation of seam cells with incomplete adult alae synthesis (PubMed:24613396). Suppresses the precocious seam cell terminal differentiation and gonadal migration defects seen in dre-1 mutants (PubMed:24613396). Weak dumpy phenotype and partially penetrant embryonic lethality (PubMed:24968003). Reduced expression of the transcription factor bed-3 which is involved in vulval development and failed division of vulval precursor cell descendents (PubMed:26234645). RNAi-mediated knockdown impairs the expression of several hypodermis-specific genes; reduces levels of clo-124 mRNA and increases levels of lin-29 mRNA (PubMed:32417234). RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:21408209).
messages: In distal tip cells, expressed from mid-L2 when gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In seam and hypodermal cells, levels are largely constant throughout larval development except for a transient peak early in L4 (PubMed:24613396).
messages: Interacts with dre-1; the interaction targets blmp-1 for proteasomal degradation (PubMed:24613396, PubMed:24968003). Interacts with ldb-1 and ham-3 (PubMed:32417234).
messages: Nucleus
messages: Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645). Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234). Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396). Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Ubiquitinated by the SCF(dre-1) complex, leading to its degradation by the proteasome.

6239:CELE T03G6.2
gene id: 6239:CELE_T03G6.2
uniprot id: Q22127
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed throughout development (PubMed:16920335). First expressed in embryos from the 1.5-fold stage (PubMed:16920335). Highly expressed during the L2 stage of larval development (PubMed:16920335).
messages: Isoform b: Expressed in body wall muscle cells, pharyngeal muscles, rectal gland cells, vulval and uterine muscles and neurons in the head and ventral nerve cord (PubMed:16920335). Isoform c: Expressed in body wall muscle cells, neurons in the head, nerve ring, ventral and dorsal nerve cords and epidermal cells in the tail (PubMed:16920335).
messages: Nucleus
messages: Orphan nuclear receptor (Probable). Plays a role in morphogenesis and elongation during embryonic and larval development (PubMed:16920335). Plays a role in muscle formation and motility (PubMed:16920335, PubMed:18616929).
messages: RNAi-mediated knockdown results in arrest due to elongation and morphogenesis defects at the embryonic or larval stages in 30% of offspring (PubMed:16920335). Furthermore, embryos have highly disorganized epithelial cells (PubMed:16920335). RNAi-mediated knockdown in adults results in mis-localized or missing body wall muscle cells (PubMed:16920335).

6239:CELE T27F7.4
gene id: 6239:CELE_T27F7.4
uniprot id: G5EDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F47A4.5
gene id: 6239:CELE_F47A4.5
uniprot id: Q20500
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the patatin family.
messages: Mutant animals generate fewer progeny and slower larval development.
messages: Phospholipase that plays a critical role during oogenesis, ovulation, and/or embryogenesis.

6239:CELE T11B7.3
gene id: 6239:CELE_T11B7.3
uniprot id: A5JYR8
uniprot id: A5JYR9
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C17G10.8
gene id: 6239:CELE_C17G10.8
uniprot id: Q09979
names: Subcellular Location Annotation
messages: Peroxisome

6239:CELE VC5.4
gene id: 6239:CELE_VC5.4
uniprot id: Q9TYU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autoacetylation at Lys-268 is required for binding histones with high affinity and for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus
messages: Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A (PubMed:15068795). Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates (PubMed:15068795, PubMed:20181741).

6239:CELE Y23H5A.4
gene id: 6239:CELE_Y23H5A.4
uniprot id: O76615
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE B0414.3
gene id: 6239:CELE_B0414.3
uniprot id: O01833
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

6239:CELE T21E12.4
gene id: 6239:CELE_T21E12.4
uniprot id: A0A163VTS9
uniprot id: Q19020
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron (PubMed:20510931). This function may involve the regulation of dynein by pct-1 and/or cdk-5 (PubMed:20510931). Involved in the formation of synapses in the dorsal region during synaptic remodeling of DD motor neurons (PubMed:21609829). Required for anterograde trafficking of dense-core vesicles in the DB motor neuron dendrites (PubMed:22699897). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). May play a role in the pairing of homologous chromosomes during meiosis (PubMed:26483555).
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: RNAi-mediated knockdown prevents sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity, par-1, par2 and par-6 asymmetric localization and pseudocleavage formation (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038). RNAi-mediated knockdown in a fbf-2 loss of function background results in sterility and the formation of small endomitotic oocytes (PubMed:27864381).
messages: cytoskeleton

6239:CELE ZC482.5
gene id: 6239:CELE_ZC482.5
uniprot id: G5ECN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE H43I07.1
gene id: 6239:CELE_H43I07.1
uniprot id: A0A168H995
uniprot id: A0A168H9C2
names: Similarity
messages: Belongs to the OPA3 family.

6239:CELE Y54H5A.2
gene id: 6239:CELE_Y54H5A.2
uniprot id: Q9BL64
names: Similarity
messages: Belongs to the HGH1 family.

6239:CELE F28D1.1
gene id: 6239:CELE_F28D1.1
uniprot id: Q19873
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE Y94H6A.5
gene id: 6239:CELE_Y94H6A.5
uniprot id: Q688Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

6239:CELE JC8.6
gene id: 6239:CELE_JC8.6
uniprot id: Q95QD7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-54 family.
messages: Chromosome
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1.
messages: Decreased protein levels of DRM complex components including lin-9 and lin-52 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514). RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246).
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription.
messages: The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn(2+) ions.
messages: Widely expressed. Present in most cells from the embryo through the adulthood.

6239:CELE Y105E8A.11
gene id: 6239:CELE_Y105E8A.11
uniprot id: Q9NEY7
names: Similarity
messages: Belongs to the BolA/IbaG family.

6239:CELE C43E11.9
gene id: 6239:CELE_C43E11.9
uniprot id: P91154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

6239:CELE C01B7.6
gene id: 6239:CELE_C01B7.6
uniprot id: Q17551
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191, PubMed:18434533). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191, PubMed:18434533). May function in concert with C-type lectin domain-containing protein clec-38 in regulating axon outgrowth (PubMed:18434533). May play a role in the formation of muscle connections between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: Belongs to the RING-Cys relay (RCR) family.
messages: Expression is seen in the pharynx, coelomocytes and distal tip cell. Most abundant expression is in axons of the nerve ring neuropil. Expression is not seen in body wall muscle, hypodermis or intestine.
messages: First expressed in comma stage embryos and persists through to adulthood.
messages: In mutants, mechanosensory neurons fail to accumulate tagged vesicles, retract synaptic branches and ectopically extend axons (PubMed:10839354). Some motor neurons branch and overgrow, others show altered synaptic organization (PubMed:10839354). Fewer body wall muscle connections to target motor neurons (PubMed:27123983).
messages: Interacts with rae-1 (PubMed:22357847). Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641).
messages: The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
messages: The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.
messages: axon

6239:CELE ZK1193.1
gene id: 6239:CELE_ZK1193.1
uniprot id: P18835
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE C17H12.14
gene id: 6239:CELE_C17H12.14
uniprot id: Q95X44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the V-ATPase E subunit family.
messages: Cytoplasm
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:12853134, PubMed:16684534). Expressed in the excretory cell, intestine and hypodermis throughout all developmental stages and in adults (at protein level) (PubMed:12853134, PubMed:16684534).
messages: Expressed in the excretory cell and syncytial hypodermal cells (at protein level) (PubMed:12853134, PubMed:16684534, PubMed:16785323). Expressed in the intestine (at protein level) (PubMed:16684534).
messages: Larvae are arrested at the L1 stage (PubMed:16684534). Larvae exhibit swollen vacuoles in the hypodermis of the head region, gradually spreading throughout the whole body (PubMed:16684534). Pharyngeal pumping ceases at L2 larval stage with many vacuoles covering the entire body (PubMed:16684534). Causes necrotic cell death in intestine and hypodermis (PubMed:16684534). RNAi-mediated knockdown causes sterility, formation of endomitotic oocytes in the proximal gonads, and impaired ovulation (PubMed:12853134). Diakinesis stage oocytes are displaced toward distal gonads (PubMed:12853134). Impaired yolk uptake by the oocytes from the pseudoceolomic cavities (PubMed:12853134, PubMed:16785323). Impaired acidification and food digestion of the intestine (PubMed:16684534). Causes an increase in the section of the excretory canal, which often has multiple lumens and abnormal whorls (PubMed:16785323). Does not affect alae formation in larvae (PubMed:16785323). Progeny is arrested at the embryonic stage or at the L1 larval stage (PubMed:12853134, PubMed:16785323). RNAi-mediated knockdown in embryos causes arrest at the one-cell stage (PubMed:12853134).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Regulates pH homeostasis in the intestine (PubMed:16684534). Probably by regulating cytoplasmic pH, required for cell survival in the intestine and hypodermis (PubMed:16684534). Involved in receptor-mediated endocytosis (PubMed:12853134, PubMed:16785323). Involved in embryogenesis and larval development (PubMed:12853134, PubMed:16785323).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.

6239:CELE Y53C12A.2
gene id: 6239:CELE_Y53C12A.2
uniprot id: O18210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE ZK218.11
gene id: 6239:CELE_ZK218.11
uniprot id: O46004
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K05B2.3
gene id: 6239:CELE_K05B2.3
uniprot id: P90900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein.
messages: Expressed in the larva in the pharyngeal-intestinal valve, the rectum and some neurons of the tail. Highly expressed in the intestine of the newly formed dauer larva. Colocalizes with ifb-1. Not expressed in the intestine of normal developmental stages.
messages: Probably forms some heteromeric filaments with ifb-1.

6239:CELE Y18D10A.17
gene id: 6239:CELE_Y18D10A.17
uniprot id: Q9XW17
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LSM14 family.
messages: Nucleus
messages: RNAi-mediated knockdown significantly reduces protein levels of ATP-dependent chaperones cdc-48.1 and cdc-48.2 in embryos.
messages: Transcriptional regulator (PubMed:18430416). Involved in modulating embryonic expression of ATP-dependent chaperone cdc-48.1 (PubMed:18430416). May play a role in mRNA gene silencing, and RNA granule (P-body) assembly (PubMed:29510985).

6239:CELE C05C10.1
gene id: 6239:CELE_C05C10.1
uniprot id: Q09448
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE C47B2.6
gene id: 6239:CELE_C47B2.6
uniprot id: Q564Q1
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important for the synthesis of glycoproteins and glycolipids.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in gonads, vulva, intestine, hypdermis and nervous system.

6239:CELE F22F1.2
gene id: 6239:CELE_F22F1.2
uniprot id: Q19742
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F35H12.2
gene id: 6239:CELE_F35H12.2
uniprot id: H2KZZ6
names: Disruption Phenotype
names: Function
messages: RNAi-mediated knockdown results in increased expression of the lin-41 protein, which is a target of the let-7 microRNA.
messages: Rab GTPase activating protein for the small GTPases rab-6.1 and rab-6.2 (Probable). Probably acts through rab-6.1 and rab-6.2 to play a role in microRNA-mediated gene silencing in different tissue types (PubMed:33826611). Required for seam cell division and alae formation (PubMed:33826611).

6239:CELE C55A6.2
gene id: 6239:CELE_C55A6.2
uniprot id: E9P886
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in body wall muscles (PubMed:20519502). Not expressed in sensory neurons (PubMed:20519502).
messages: Expressed in embryos and adults.
messages: Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating (PubMed:27635036). Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons (PubMed:23000142).

6239:CELE R13A5.12
gene id: 6239:CELE_R13A5.12
uniprot id: Q95Y89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pescadillo family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

6239:CELE F25H5.3
gene id: 6239:CELE_F25H5.3
uniprot id: O17835
uniprot id: O17836
uniprot id: Q3S1I8
names: Similarity
messages: Belongs to the pyruvate kinase family.

6239:CELE Y42A5A.1
gene id: 6239:CELE_Y42A5A.1
uniprot id: Q9U2H2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE C04F12.4
gene id: 6239:CELE_C04F12.4
uniprot id: Q9XVE9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

6239:CELE Y97E10AL.1
gene id: 6239:CELE_Y97E10AL.1
uniprot id: Q965S1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y37D8A.10
gene id: 6239:CELE_Y37D8A.10
uniprot id: Q9XWW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Endoplasmic reticulum membrane

6239:CELE K01H12.2
gene id: 6239:CELE_K01H12.2
uniprot id: G5EFW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE T10H10.1
gene id: 6239:CELE_T10H10.1
uniprot id: P91443
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Interacts with unc-98.
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

6239:CELE F28C6.2
gene id: 6239:CELE_F28C6.2
uniprot id: Q19862
names: Similarity
messages: Belongs to the AP-2 family.

6239:CELE Y116A8B.5
gene id: 6239:CELE_Y116A8B.5
uniprot id: O62403
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE R07G3.1
gene id: 6239:CELE_R07G3.1
uniprot id: Q05062
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the intestine and seam cells.
messages: Highest levels at the embryonic stage, decreasing progressively during development, except for an increase at the L3 stage (PubMed:8514766). Expressed in hypodermal cells during elongation throughout the second phase of embryogenesis (PubMed:8824291).
messages: Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3 (PubMed:11412996, PubMed:11412997). Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419). May play a role in controlling canal length and in maintaining Golgi and ER stability during excretory canal elongation, probably downstream of ccm-3, which may regulate its activity and expression levels (PubMed:25743393). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Involved in toca-1 and toca-2-mediated protein trafficking controlling the recycling of endocytic cargo protein mig-14 to the Golgi apparatus (PubMed:25775511). Plays a role in male tail tip morphogenesis (PubMed:21408209). Together with kpc-1 and chin-1, plays a role in guiding axons from neurons, including AIY interneurons, into the nerve ring (PubMed:28846083).
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown in distal tip cells (DTC) causes additional turns during their migration (PubMed:19023419). RNAi-mediated knockdown in addition, causes a truncation of excretory canals associated with the formation of cysts and a reduced distribution of Golgi and ER components along the excretory canal length (PubMed:25743393). RNAi-mediated knockdown results in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space, and accumulation of endocytic cargo protein mig-14 in late endosomes and expansion of recycling endosomes that express toca-1 and toca-2 (PubMed:19798448, PubMed:25775511). RNAi-mediated knockdown enhances the axon guidance defects in glia and sublateral neurons of the kpc-1 gk mutant, in which non-commissural interneurons AIY fail to extend dorsally and enter the nerve ring (PubMed:28846083).
messages: Recycling endosome
messages: The GTP-bound, but not the GDP-bound, form binds to the p21-activated kinase (pak-1) (PubMed:8824291). Interaction with par-6 required for activation of the par-3/par-6/pkc-3 complex (PubMed:11412997). Interacts with toca-1 and toca-2 (PubMed:25775511). May interact with unc-89 (via DH and PH domains); the interaction does not stimulate GTPase activity in vitro (PubMed:18801371).

6239:CELE C25A1.2
gene id: 6239:CELE_C25A1.2
uniprot id: O17593
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE E01A2.2
gene id: 6239:CELE_E01A2.2
uniprot id: Q966L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity).
messages: Belongs to the ARS2 family.
messages: Nucleus

6239:CELE C48D5.1
gene id: 6239:CELE_C48D5.1
uniprot id: P41829
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: In hermaphrodites, expressed in the developing spermatheca and dorsal uterus (PubMed:18096150, PubMed:20506374). Expression includes the 8 cells of the dorsal somatic gonad primordium and the sujc cells that form the core of the spermatheca-uterine valve (PubMed:18096150). Expressed in the precursor cells of the spermatheca-sheath lineages (SS cells) and in the precursors and descendents of the dorsal-uterine lineage (DU cells) (PubMed:20506374). In both hermaphroditic and male animals, expressed in a pair of head chemosensory neurons (PubMed:18096150).
messages: Most abundant in larval stage L3 (PubMed:7816808). Expressed in larval stages L3 and L4 (PubMed:18096150, PubMed:20506374). Weakly expressed in adult animals (PubMed:18096150).
messages: Nucleus
messages: Reduced brood size, abnormal egg morphology and arrested egg development. Defects in ovulation with fragmentation of the proximal oocyte and endomitosis. Misplacement of ovulated oocytes into the gonad arms due to a lack of spermatheca-uterine valve formation. Degeneration of gonad tissue. Decreased spermatheca organ size due to decreased spermatheca cell number. Disorganized actin microfilaments in the spermatheca, lack of distal constriction and defects in spermathecal cell differentiation. Misexpression of let-502 in all cells of the spermatheca instead of restricted expression to the distal and proximal regions of the spermatheca. Abnormal differentiation and morphology of the sujc cells that form the core of the spermatheca-uterine valve (PubMed:18096150). Lack of cell divisions of the proximal spermatheca precursor daughter cells due to a failure of progressing to S phase during larval stage L4 (PubMed:25529479). In a fzr-1(ku298) mutant background, increase in spermatheca nuclei number as compared to the nhr-6 single mutant (PubMed:25529479). In a fog-2(q71) mutant background, a large mass of fragmented oocytes in the spermatheca and uterus (PubMed:18096150). RNAi-mediated knockdown leads to reduced brood size and abnormal egg morphology (PubMed:20506374). In a vab-1(e2), vab-1(e699), vab-2(ju1) or vab-2(e96) mutant background, enhanced reduction in brood size (PubMed:25529479). In a vab-2(ju1) mutant background, reduced spermatheca cell number and abnormal spermatheca morphology (PubMed:25529479). In a RNAi-sensitive rrf-3(pk1426) mutant background, defects in spermatheca morphology, including decreased organ size, decreased spermatheca cell number and misplaced spermatheca nuclei. In a RNAi-sensitive eri-1(mg366) mutant background, reduced brood size, abnormal egg morphology and arrested eggs (PubMed:18096150).
messages: The NR LBD domain and the nuclear receptor DNA binding domain are sufficient for binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'.
messages: Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:20506374). Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation (PubMed:18096150, PubMed:25529479). Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4 (PubMed:18096150, PubMed:25529479). Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage (PubMed:25529479). Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which are generating the spermatheca-uterine valve (PubMed:18096150).

6239:CELE ZK632.3
gene id: 6239:CELE_ZK632.3
uniprot id: P34649
names: Disruption Phenotype
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Expressed in tail neurons (PVQ and PHAL/PQR).
messages: RNAi-mediated knockdown causes no obvious phenotype.

6239:CELE C33D9.1
gene id: 6239:CELE_C33D9.1
uniprot id: G5ECM5
uniprot id: X5LV34
uniprot id: X5M8S5
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE Y108G3AL.7
gene id: 6239:CELE_Y108G3AL.7
uniprot id: A0A0K3AXH1
names: Function
names: Subcellular Location Annotation
messages: DNA-binding protein which modulates activity of several transcription factors (By similarity). Plays a role in the modulation of endoplasmic reticulum (ER) homeostasis during chemical and pathogen stress, including exposure to the Gram-negative bacterium P.aeruginosa (PubMed:30287474).
messages: Nucleus

6239:CELE F08B12.2
gene id: 6239:CELE_F08B12.2
uniprot id: Q19189
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (By similarity). The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity). PEX12/prx-12 also regulates PEX5/prx-5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10/prx-10 (By similarity). When PEX5 recycling is compromised, PEX12/prx-12 stimulates PEX10-mediated polyubiquitination of PEX5/prx-5, leading to its subsequent degradation (By similarity).
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel.
messages: Peroxisome membrane
messages: The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
messages: The three subunits of the retrotranslocation channel (PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5/prx-5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.

6239:CELE C36C5.7
gene id: 6239:CELE_C36C5.7
uniprot id: Q8ITZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K07H8.2
gene id: 6239:CELE_K07H8.2
uniprot id: Q965K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE F53F4.9
gene id: 6239:CELE_F53F4.9
uniprot id: K8F7R4
uniprot id: Q20721
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE E04D5.1
gene id: 6239:CELE_E04D5.1
uniprot id: Q19052
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

6239:CELE F16D3.1
gene id: 6239:CELE_F16D3.1
uniprot id: Q19490
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE C35C5.1
gene id: 6239:CELE_C35C5.1
uniprot id: G5EBL3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:2759421, PubMed:10364546). Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:2759421, PubMed:10364546, PubMed:14660541, PubMed:11937488). Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:9056777, PubMed:10364546, PubMed:14660541). May confer protection against toxicity induced by heavy metals such as arsenite (PubMed:25204677).
messages: Component of the SDC complex, which consists of sdc-1, sdc-2 and sdc-3. Within the complex, interacts with sdc-1 and sdc-3.
messages: Expressed in embryos after the 40-cell stage and in adults.
messages: Expressed in hermaphrodites (XX), but absent in males (XO) (at protein level).
messages: Results in high lethality of hermaphrodites (XX) and in masculinization of surviving XX animals (PubMed:2759421). Disrupts the X-chromosome specific localization of sdc-3, dpy-21, dpy-26, dpy-27 and mix-1 (PubMed:9056777, PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:14660541). RNAi-mediated knockdown results in 86% viability of hermaphrodites (PubMed:23666922). RNAi-mediated knockdown results in increased sensitivity to the heavy metal arsenite (PubMed:25204677). RNAi-mediated knockdown reduces the viability of hermaphrodites to 19% in a double xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 11% in a triple sea-1(y356), xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 42% in a triple sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 51% in a quadruple sea-1(y356), sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922).

6239:CELE R186.8
gene id: 6239:CELE_R186.8
uniprot id: Q7YTL0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

6239:CELE M18.1
gene id: 6239:CELE_M18.1
uniprot id: Q21556
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZK1128.7
gene id: 6239:CELE_ZK1128.7
uniprot id: G5EF99
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F22B5.2
gene id: 6239:CELE_F22B5.2
uniprot id: Q19706
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal morphology (dumpy phenotype), slow growth, sterile and in severe cases embryonic lethal.
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. Binds to GC-rich 5'UTRs in cholinergic motor neurons, thereby may play a role in translational regulation of mRNAs involved in neuropeptide signaling and stress response, including hlh-30 isoform d and ncs-2 (PubMed:34323215).

6239:CELE T27B1.1
gene id: 6239:CELE_T27B1.1
uniprot id: Q22830
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IFT172 family.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for the maintenance and formation of chemosensory cilia that detect chemosensory cues (PubMed:10545497).
messages: Expressed in amphid and phasmid chemosensory neurons, where it appears to concentrate at the base of the transition zones, which correspond to the basal bodies of motile and sensory cilia. Moves in the retrograde direction along cilia and dendrites, suggesting that it is retrieved from the distal endings of the cilia by a retrograde transport pathway that moves it along cilia and then dendrites, back to the neuronal cell body.
messages: Worms display defects in ciliary structure resulting in defects in ability and osmotic avoidance behavior.
messages: cilium

6239:CELE F38B6.4
gene id: 6239:CELE_F38B6.4
uniprot id: Q20143
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

6239:CELE T05E12.4
gene id: 6239:CELE_T05E12.4
uniprot id: Q9XUR5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C42C1.5
gene id: 6239:CELE_C42C1.5
uniprot id: A3QMC8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

6239:CELE ZC410.7
gene id: 6239:CELE_ZC410.7
uniprot id: A0A1N7SYX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

6239:CELE C27F2.10
gene id: 6239:CELE_C27F2.10
uniprot id: Q95QU0
names: Similarity
messages: Belongs to the CSN12 family.

6239:CELE R07E5.13
gene id: 6239:CELE_R07E5.13
uniprot id: Q21828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: May mediate the uptake of pyruvate into mitochondria.
messages: Mitochondrion inner membrane

6239:CELE W03F11.3
gene id: 6239:CELE_W03F11.3
uniprot id: O01778
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZK1053.5
gene id: 6239:CELE_ZK1053.5
uniprot id: G5EEQ3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE Y38E10A.4
gene id: 6239:CELE_Y38E10A.4
uniprot id: Q9NAK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C46F4.2
gene id: 6239:CELE_C46F4.2
uniprot id: Q18660
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE C34C12.7
gene id: 6239:CELE_C34C12.7
uniprot id: Q09271
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F32A5.4
gene id: 6239:CELE_F32A5.4
uniprot id: Q19948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I33 family.
messages: Secreted

6239:CELE ZK1098.11
gene id: 6239:CELE_ZK1098.11
uniprot id: G5EE42
names: Similarity
messages: Belongs to the NATD1 family.

6239:CELE ZK75.2
gene id: 6239:CELE_ZK75.2
uniprot id: Q09627
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T23B3.2
gene id: 6239:CELE_T23B3.2
uniprot id: P91491
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE F52D1.1
gene id: 6239:CELE_F52D1.1
uniprot id: O17352
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

6239:CELE F30H5.2
gene id: 6239:CELE_F30H5.2
uniprot id: Q09982
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: May have antimicrobial activity.
messages: Secreted

6239:CELE C34D1.3
gene id: 6239:CELE_C34D1.3
uniprot id: Q18434
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family.
messages: Defective in chemotactic responses to attractants and repellents and in osmotic and mechanosensory avoidance.
messages: Expressed in sensory neurons in the head and tail. Expressed in amphid AWC neurons, to a lesser extent in AWB and weakly in AWA, ASH and ADF neurons (head sensory neurons). Expressed in phasmid PHA and PHB neurons (tail sensory neurons).
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:10192394). This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis (PubMed:9459442, PubMed:15342507). Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione (PubMed:12694294). Displays a redundant function with gpa-3 in chemotactic responses (PubMed:12694294). Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons (PubMed:14988722). Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid (PubMed:12694294). Involved in osmotic avoidance and mechanosensory responses (PubMed:12694294). Involved in specifying fan-like morphology of cilia of head sensory neurons AWC (PubMed:9459442). Plays a role in the detection of preferred food sources by mediating the recognition of food odors in olfactory sensory neurons (PubMed:25009271).
messages: cilium
messages: dendrite

6239:CELE F56A8.6
gene id: 6239:CELE_F56A8.6
uniprot id: O45577
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y116A8A.2
gene id: 6239:CELE_Y116A8A.2
uniprot id: Q9U2W1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZK1037.9
gene id: 6239:CELE_ZK1037.9
uniprot id: O45991
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F40F8.10
gene id: 6239:CELE_F40F8.10
uniprot id: Q20228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

6239:CELE C10A4.8
gene id: 6239:CELE_C10A4.8
uniprot id: Q17895
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In larva and adult, expressed in the M3 pharyngeal motor neurons, extrapharyngeal neurons in the head, the PQR tail neurons, rectal cells, vulva cells, the spermetheca-uterine valve, body wall muscle cells and neurons of the ventral nerve cord. In the embryo, expressed in pharyngeal cells, extrapharyngeal head neurons and within the tail. Expressed in body wall muscle cells during late embryonic stages. Expressed in the mother cells of the M2 and M3 pharyngeal motor neurons precursor cells at the embryonic bean stage and subsequently in the M2 and M3 cells as they are born. Expression is sustained only in the two M3 cells up to at least the 5-day-old adult. In contrast, expression gradually declines in the M2 cells beginning from the time of their birth, and is completely undetectable by the time of hatching.
messages: Nucleus
messages: RNAi-mediated knockdown results in defective formation of the distal end of the two M2 pharyngeal motor neurons.
messages: Required in the M3 pharyngeal motor neuron to guide the growth cone of the sister M2 motor neuron during axon development.

6239:CELE F55H2.1
gene id: 6239:CELE_F55H2.1
uniprot id: G5ECR5
uniprot id: P34461
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Isoform 2 is preferentially expressed in eggs.
messages: Isoforms are expressed differently during development, while isoform 2 is preferentially expressed in eggs, isoform 1 is preferentially expressed in the adults.
messages: Membrane
messages: Protects cells against oxidative stress by converting superoxide radicals to hydrogen peroxide (PubMed:9628580). Oxidative stress is involved in various biological dysfunctions and senescence (PubMed:9628580).
messages: extracellular space

6239:CELE Y39E4B.9
gene id: 6239:CELE_Y39E4B.9
uniprot id: C3JXF0
uniprot id: D0Z5N7
uniprot id: Q6QMT2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine onto carbohydrate substrates (By similarity). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5 (PubMed:12944392). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796).
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein.

6239:CELE R06F6.4
gene id: 6239:CELE_R06F6.4
uniprot id: Q09415
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F14B4.3
gene id: 6239:CELE_F14B4.3
uniprot id: Q27493
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antisense ribosomal siRNAs silence rRNA expression during the elongation phase by decreasing rpoa-2 occupancy downstream of the RNAi-targeted region in nrde-2-dependent manner.
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Specifically binds to 18S, 5.8S and 26S rDNA, but not to 5S rDNA (PubMed:34365510).
messages: Nucleus
messages: RNAi-mediated knockdown causes sterility.
messages: nucleolus

6239:CELE C11E4.2
gene id: 6239:CELE_C11E4.2
uniprot id: Q95003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutathione peroxidase family.
messages: extracellular space

6239:CELE F09C12.1
gene id: 6239:CELE_F09C12.1
uniprot id: Q10052
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F10D2.7
gene id: 6239:CELE_F10D2.7
uniprot id: O16916
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C46H11.8
gene id: 6239:CELE_C46H11.8
uniprot id: Q9GYJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T05A6.2
gene id: 6239:CELE_T05A6.2
uniprot id: G5EEJ2
uniprot id: Q22198
names: Similarity
messages: Belongs to the CDI family.

6239:CELE C18C4.9
gene id: 6239:CELE_C18C4.9
uniprot id: Q18086
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the globin family.
messages: By anoxia.
messages: Does not bind carbon monoxide (CO), nitric oxide (NO) or CN(-).
messages: Expressed at all developmental stages.
messages: Expressed in the head and tail neurons and nerve cord.
messages: May play a role as physiological sensor for oxygen via redox signaling and/or electron transport.

6239:CELE Y67D2.2
gene id: 6239:CELE_Y67D2.2
uniprot id: Q9BKQ6
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE F10D11.6
gene id: 6239:CELE_F10D11.6
uniprot id: H9G2Z8
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE F59E10.3
gene id: 6239:CELE_F59E10.3
uniprot id: O17901
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

6239:CELE C36A4.3
gene id: 6239:CELE_C36A4.3
uniprot id: Q1HB05
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE M153.2
gene id: 6239:CELE_M153.2
uniprot id: Q21545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE ZK546.13
gene id: 6239:CELE_ZK546.13
uniprot id: Q23523
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F32E10.1
gene id: 6239:CELE_F32E10.1
uniprot id: Q19974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

6239:CELE F18A12.8
gene id: 6239:CELE_F18A12.8
uniprot id: O16796
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Probable cell surface protease.

6239:CELE F59F3.1
gene id: 6239:CELE_F59F3.1
uniprot id: Q21038
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed in the ALA neuron.
messages: Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.

6239:CELE Y108G3AL.3
gene id: 6239:CELE_Y108G3AL.3
uniprot id: Q95Y36
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CFAP36 family.
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme

6239:CELE Y22F5A.6
gene id: 6239:CELE_Y22F5A.6
uniprot id: Q9XXS1
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: By heavy metal stress conditions, in response to Cu(2+).
messages: Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner.
messages: RNAi-mediated knockdown results in partial sensitivity to Cu(2+) ions with less than 70% of animals reaching adulthood 4 days after egg laying.
messages: Weak similarity to other lysozymes and lacks the conserved active site.

6239:CELE F36A2.4
gene id: 6239:CELE_F36A2.4
uniprot id: P90863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F18E9.2
gene id: 6239:CELE_F18E9.2
uniprot id: Q19569
names: Disruption Phenotype
names: Function
names: Induction
messages: May regulate lifespan in response to food availability and oxidative stress.
messages: Reduced lifespan when diet is restricted, and in the presence of the oxidative stress inducer paraquat (PubMed:19783783). Increased pha-4 and cup-4 expression when diet is restricted (PubMed:19783783). RNAi-mediated knockdown reduces lifespan and resistance to the oxidative stress inducer paraquat (PubMed:19627265, PubMed:19783783). RNAi-mediated knockdown in an eat-2 mutant background rescues lifespan, but lifespan remains greater than in wild-type (PubMed:19783783).
messages: Up-regulated when diet is restricted.

6239:CELE C06C6.4
gene id: 6239:CELE_C06C6.4
uniprot id: O62034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T02C12.1
gene id: 6239:CELE_T02C12.1
uniprot id: G5ECZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F10B5.2
gene id: 6239:CELE_F10B5.2
uniprot id: Q09305
names: Similarity
messages: Belongs to the AAR2 family.

6239:CELE F33C8.1
gene id: 6239:CELE_F33C8.1
uniprot id: Q19981
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F23B12.9
gene id: 6239:CELE_F23B12.9
uniprot id: O61667
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ced-9; the interaction results in ced-4 release from the ced-4/ced-9 complex (PubMed:15383288, PubMed:9604928). Interaction with ced-9 may enhance interaction of ced-9 with drp-1, but not with ced-4 (PubMed:21949250). A ced-9/egl-1 complex may recruit drp-1 to the mitochondrial surface (PubMed:21949250).
messages: Mutants block programmed cell death (PubMed:9604928). In an ain-1 mutant background, enhances the proportion of animals arrested at the larval stage, with egg-laying defects and with a ruptured vulva (PubMed:25432023).
messages: Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis (PubMed:12874127). Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron during embryogenesis (PubMed:20713707). During larval development, required for the elimination of transient presynaptic components upstream of ced-9, ced-4 and ced-3 apoptotic pathway (PubMed:26074078). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3 and ced-4, regulates temporal cell fate patterning during larval development (PubMed:25432023). Has been shown in two studies to be dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:19327994, PubMed:21949250). However, one study shows that during larval development, egl-1 is involved in modulating mitochondrial dynamics, perhaps acting by stabilizing the interaction between ced-9 and drp-1 in order to promote mitochondrial fission (PubMed:21949250). Involved in inducing mitochondrial fragmentation during apoptosis, probably acting via ced-9 and dynamin-related protein drp-1 (PubMed:15716954).
messages: Synapse
messages: Two studies agree that egl-1 is dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:21949250, PubMed:19327994). However, it is also reported that egl-1 can act in mitochondrial dynamics during larval development, via regulation of ced-9 (PubMed:21949250).

6239:CELE F16A11.3
gene id: 6239:CELE_F16A11.3
uniprot id: G5ECH5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Embryonic lethal in 10 percent of animals and slight increase in the number of males produced (PubMed:19087961). In oocytes, slight increase in metaphase and anaphase meiotic spindle length, persistence of microtubules around chromatids during anaphase and delay in spindle assembly in meiosis II (PubMed:19087961, PubMed:23918937). However, localization of spindle pole marker aspm-1 and the shape of the meiotic spindle are normal (PubMed:23918937). The second polar body has a larger size and in 16 percent of animals its extrusion fails resulting in aneuploidy (PubMed:19087961). The size of the polar body is further increased in a mei-1 (or646) mutant background (PubMed:23918937). Increases mei-1 phosphorylation in a gain of function mei-1 (ct46) and tbb-2 (sb26) mutant background (PubMed:23918937). In gain of function mei-1 (ct46) mutant background, RNAi-mediated knockdown partially rescues embryonic lethality and improves embryonic mitotic spindle morphology in terms of length and orientation (PubMed:19087961).
messages: Expressed in embryos.
messages: Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits (By similarity). The catalytic subunit is likely to be pph-4.1 (PubMed:19087961). Interacts (via C-terminus) with mel-26 (probably via MATH domain); the interaction targets ppfr-1 for ubiquitin-mediated proteolysis (PubMed:23918937).

6239:CELE Y54G11A.10
gene id: 6239:CELE_Y54G11A.10
uniprot id: A5PEX5
uniprot id: Q9U245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

6239:CELE R06A4.8
gene id: 6239:CELE_R06A4.8
uniprot id: O62334
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

6239:CELE F48F7.2
gene id: 6239:CELE_F48F7.2
uniprot id: Q20574
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

6239:CELE AH9.2
gene id: 6239:CELE_AH9.2
uniprot id: Q10905
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subunit
messages: Exonuclease activity is inhibited in vitro by pontacyl violet 6R (PV6R), p-chloromercuriphenyl sulfonate (PCMPS), 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), aurintricarboxylic acid (ATA), 2-morpholin-4-ylethanesulfonate (MES), 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid (DR396) and fmoc-d-Cha-OH (FDCO). Interaction with ssRNA is reduced in vitro by PV6R.
messages: Homodimer (via C-terminus) (PubMed:18981218). Interacts with crn-5; interaction promotes the DNase activity of crn-4 (PubMed:20660080, PubMed:12718884). Interacts with cps-6, crn-1 and cyn-13 (PubMed:12718884).
messages: Possesses 3'->5' exoribonuclease activity in digestion of DNA and RNA (PubMed:18981218, PubMed:27529560). Cleaves nucleic acid substrates with efficiencies in the following order: single-stranded RNA (ssRNA) > double-stranded DNA (dsDNA) > single-stranded DNA (ssDNA) (PubMed:18981218, PubMed:27529560). Involved in apoptotic DNA degradation (PubMed:12718884, PubMed:18981218).
messages: Probably binds Mg(2+) in vivo, Mn(2+) ions are found in the crystal structure.
messages: RNAi-mediated knockdown results in accumulation of apoptotic DNA in 1.5-fold stage embryos and delayed appearance of embryonic cell corpses during development.

6239:CELE F45H7.2
gene id: 6239:CELE_F45H7.2
uniprot id: C7FZT8
uniprot id: Q20440
uniprot id: Q20442
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE C28H8.3
gene id: 6239:CELE_C28H8.3
uniprot id: Q09475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Nucleus

6239:CELE C17G1.3
gene id: 6239:CELE_C17G1.3
uniprot id: Q0G821
uniprot id: Q93242
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y37D8A.14
gene id: 6239:CELE_Y37D8A.14
uniprot id: P55954
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

6239:CELE F23C8.9
gene id: 6239:CELE_F23C8.9
uniprot id: Q9TXI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress.

6239:CELE F52F12.3
gene id: 6239:CELE_F52F12.3
uniprot id: Q9XTC6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Embryonic lethal with severely defective embryonic morphogenesis with no endoderm and excess mesoderm.
messages: Expressed in the embryo.
messages: Interacts with, and is activated by, tap-1.
messages: May be autophosphorylated.
messages: Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1.

6239:CELE F56A4.10
gene id: 6239:CELE_F56A4.10
uniprot id: A0A0M9JJ71
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R106.2
gene id: 6239:CELE_R106.2
uniprot id: Q23033
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE T09E11.9
gene id: 6239:CELE_T09E11.9
uniprot id: O02309
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C09G5.1
gene id: 6239:CELE_C09G5.1
uniprot id: Q09453
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily.
messages: Cell membrane
messages: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Contributes to the generation of inhibitory postsynaptic currents.
messages: Pentamer.
messages: Postsynaptic cell membrane
messages: Synapse

6239:CELE R04D3.9
gene id: 6239:CELE_R04D3.9
uniprot id: Q21717
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C03C10.3
gene id: 6239:CELE_C03C10.3
uniprot id: P42170
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Heterodimer of a large and a small subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

6239:CELE Y17G9B.4
gene id: 6239:CELE_Y17G9B.4
uniprot id: Q9N579
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE C05D11.2
gene id: 6239:CELE_C05D11.2
uniprot id: Q11182
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS16 family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for recruitment of vps-33.1 to the HOPS complex (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2 (By similarity).
messages: Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2.
messages: Viable with a reduced number of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423). Embryos of these adults arrest in early development and lack gut granules (PubMed:15843430). Endosome/lysosome fusion defects in coelomocytes (PubMed:26783301). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556).

6239:CELE ZK1320.4
gene id: 6239:CELE_ZK1320.4
uniprot id: Q09653
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Membrane

6239:CELE AH6.3
gene id: 6239:CELE_AH6.3
uniprot id: Q09202
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0336.9
gene id: 6239:CELE_B0336.9
uniprot id: Q10580
names: Function
messages: It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing.

6239:CELE F09C6.7
gene id: 6239:CELE_F09C6.7
uniprot id: O45326
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F46B3.4
gene id: 6239:CELE_F46B3.4
uniprot id: E1B6V6
uniprot id: Q9XV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T26G10.1
gene id: 6239:CELE_T26G10.1
uniprot id: P34580
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Nucleus
messages: Probable ATP-dependent RNA helicase which may be involved in ribosome biogenesis.

6239:CELE Y71G12B.30
gene id: 6239:CELE_Y71G12B.30
uniprot id: Q4W5Q9
uniprot id: W6RTP7
uniprot id: W6SBL5
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE D1081.2
gene id: 6239:CELE_D1081.2
uniprot id: Q18955
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in muscle, varying with age, decreasing twofold during the first week of adulthood.
messages: Mutants usually hatch and appear normal in early L1, but become progressively paralyzed later during L1 (PubMed:17142668). Complete larval lethal, typically at late L1 or early L2 (PubMed:17142668). Abnormal bodywall and egg-laying muscle in hermaphrodites, but with no obvious abnormality of pharyngeal muscle or other cell types (PubMed:17142668). Five percent of the progeny from hlh-1, unc-120 double heterozygous parents exhibit partial absence of bodywall muscle and reduced expression of myosin myo-3 (PubMed:17142668). RNAi-mediated knockdown causes a low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hlh-1 or hnd-1 mutant background (PubMed:15892873). RNAi-mediated knockdown causes those embryos that survive to hatching to become uncoordinated, dumpy larvae (PubMed:15892873). RNAi-mediated knockdown causes abnormalities in muscle, including: altered mitochondrial morphology at day 6 of adulthood, two-fold to five-fold down-regulation of transcript levels at day 7 and significant increase in the number of autophagic vesicles (PubMed:29314608). RNAi-mediated knockdown causes a reduction in average lifespan by 16% (PubMed:29314608). RNAi-mediated knockdown on a daf-2 mutant background causes a dramatic decrease in physical performance at day 18 (PubMed:29314608).
messages: Nucleus
messages: Transcription factor (By similarity). Regulates myogenesis, in cooperation with transcription factors hlh-1 and hnd-1 (PubMed:15892873, PubMed:17142668). Required for maintenance of muscle in adulthood (PubMed:29314608).

6239:CELE T04H1.9
gene id: 6239:CELE_T04H1.9
uniprot id: G5EF01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE ZK836.1
gene id: 6239:CELE_ZK836.1
uniprot id: Q23628
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.

6239:CELE F25H2.1
gene id: 6239:CELE_F25H2.1
uniprot id: Q93565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

6239:CELE C25G4.10
gene id: 6239:CELE_C25G4.10
uniprot id: O18023
names: Subcellular Location Annotation
messages: Cell membrane

6239:CELE Y54E10A.2
gene id: 6239:CELE_Y54E10A.2
uniprot id: G5EE66
names: Similarity
messages: Belongs to the COG1 family.

6239:CELE F59B10.6
gene id: 6239:CELE_F59B10.6
uniprot id: Q09954
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y116F11B.5
gene id: 6239:CELE_Y116F11B.5
uniprot id: Q9GRV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T01B7.7
gene id: 6239:CELE_T01B7.7
uniprot id: P20784
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Localizes in stripes along the alae.
messages: Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). May play a role in cuticle remodeling in response to the environment (PubMed:32229533). Involved in body morphogenesis (PubMed:21094156).

6239:CELE C50B8.3
gene id: 6239:CELE_C50B8.3
uniprot id: Q18726
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIA30 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Required for normal growth and reproduction.
messages: Mitochondrion
messages: RNAi-mediated knockdown impairs mitochondrial complex I assembly. Reduced body size, reduced fat content, fewer embryos and an extended egg laying period. These phenotypes are exacerbated when nuaf-3 is simultaneously knocked down.

6239:CELE F10B5.6
gene id: 6239:CELE_F10B5.6
uniprot id: G5EG38
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the APC6/CDC16 family.
messages: Cell junction
messages: Expressed in GABA motor neurons.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
messages: RNAi-mediated knockdown results arrest at the one-cell stage of embryogenesis.
messages: Synapse
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE C26B2.1
gene id: 6239:CELE_C26B2.1
uniprot id: Q18194
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

6239:CELE F45F2.5
gene id: 6239:CELE_F45F2.5
uniprot id: G4SFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE F58G4.1
gene id: 6239:CELE_F58G4.1
uniprot id: Q21000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

6239:CELE B0273.3
gene id: 6239:CELE_B0273.3
uniprot id: O44168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE C29G2.5
gene id: 6239:CELE_C29G2.5
uniprot id: O16884
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C07F11.1
gene id: 6239:CELE_C07F11.1
uniprot id: Q9N5Z3
names: Similarity
messages: Belongs to the Toll-like receptor family.

6239:CELE C04C3.5
gene id: 6239:CELE_C04C3.5
uniprot id: Q6I6D4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CLUAP1 family.
messages: Cilia of at least eight pairs of amphid neurons from mutant dyf(m185) animals are truncated at a middle segment, and empty amphidial sockets were seen indicating cilium structural abnormalities.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for sensory cilia biogenesis (PubMed:15713455).
messages: Expressed in a subset of sensory neurons including eight pairs of amphid neurons (ASE, ADF, ASG, ASH, ASI, ASJ, ASK and ADL), six inner labial neurons (IL2s) and two pairs of phasmid neurons (PHA and PHB).
messages: axon
messages: cilium
messages: dendrite

6239:CELE W02D3.6
gene id: 6239:CELE_W02D3.6
uniprot id: O01813
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE F54E4.4
gene id: 6239:CELE_F54E4.4
uniprot id: Q93787
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K03A11.6
gene id: 6239:CELE_K03A11.6
uniprot id: A7LPH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K11C4.4
gene id: 6239:CELE_K11C4.4
uniprot id: P41931
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine (PubMed:7498733, PubMed:19762559). Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis (PubMed:19762559).
messages: Deletion mutant pc13 has a reduced brood size and reduced enzymatic activity (PubMed:7498733). Smaller body size as compared to wild-type. Reduced putrescine and spermidine levels (PubMed:19762559). Double knockout with the polyamine transporter catp-5 results in a reduced brood size, delayed postembryonic development, and a more marked reduction in putrescine and spermidine levels as compared to the single mutants (PubMed:19762559).
messages: Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.
messages: Inhibited by antizyme (AZ) in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

6239:CELE F48F7.3
gene id: 6239:CELE_F48F7.3
uniprot id: Q20575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F52E4.7
gene id: 6239:CELE_F52E4.7
uniprot id: Q20678
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC3 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE B0207.6
gene id: 6239:CELE_B0207.6
uniprot id: O01426
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

6239:CELE F59C6.12
gene id: 6239:CELE_F59C6.12
uniprot id: Q564X7
names: Similarity
messages: Belongs to the UPF0598 family.

6239:CELE F32A7.5
gene id: 6239:CELE_F32A7.5
uniprot id: P91859
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAP1A/MAP1B/MAP1S family.
messages: Expressed in somatic tissues including neurons, body wall muscle cells, the vulva, vulval muscle cells, the hypodermis, seam cells, and intestinal cells at the L4 stage of larval development.
messages: Interacts with dlg-1.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: dendrite

6239:CELE F46F5.7
gene id: 6239:CELE_F46F5.7
uniprot id: A0A0S4XRR1
uniprot id: A0A0S4XRV8
uniprot id: Q9TXY2
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y116A8C.28
gene id: 6239:CELE_Y116A8C.28
uniprot id: A0A0K3ARK9
uniprot id: D3NQA9
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

6239:CELE F58G6.8
gene id: 6239:CELE_F58G6.8
uniprot id: A0A8D6UGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE H27M09.2
gene id: 6239:CELE_H27M09.2
uniprot id: Q9N5K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
messages: Nucleus

6239:CELE C24B5.4
gene id: 6239:CELE_C24B5.4
uniprot id: Q3Y402
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

6239:CELE F41B5.7
gene id: 6239:CELE_F41B5.7
uniprot id: A0A0M7RF98
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T06C12.14
gene id: 6239:CELE_T06C12.14
uniprot id: O18039
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W01D2.1
gene id: 6239:CELE_W01D2.1
uniprot id: O62388
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

6239:CELE M01E5.5
gene id: 6239:CELE_M01E5.5
uniprot id: O17966
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type IB topoisomerase family.
messages: Chromosome
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Expressed in male germ cells and in mature sperm.
messages: Isoform a: only expressed in embryos (PubMed:9540836). Isoform b: present at all developmental stages (PubMed:9540836). Not expressed during spermatocyte meiosis (PubMed:16943775).
messages: Nucleus
messages: Predominant isoform.
messages: RNAi-mediated knockdown causes abnormal gonad morphology, enlarged sperm nuclei and aberrant progression through meiosis. Oocytes appear to have undergone endomitotic reduplication.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Required for normal spermatogenesis and oogenesis (PubMed:16943775).
messages: nucleolus

6239:CELE F53H1.1
gene id: 6239:CELE_F53H1.1
uniprot id: Q965K2
uniprot id: U4PBN2
uniprot id: U4PRR4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

6239:CELE C37E2.2
gene id: 6239:CELE_C37E2.2
uniprot id: Q93354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

6239:CELE T22C1.10
gene id: 6239:CELE_T22C1.10
uniprot id: Q22670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm
messages: Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.

6239:CELE C24H11.2
gene id: 6239:CELE_C24H11.2
uniprot id: Q9XVD6
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE R07B7.11
gene id: 6239:CELE_R07B7.11
uniprot id: Q21801
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.

6239:CELE Y75B8A.4
gene id: 6239:CELE_Y75B8A.4
uniprot id: Q9XW87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

6239:CELE C05E11.4
gene id: 6239:CELE_C05E11.4
uniprot id: P54145
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Involved in the uptake of ammonia.
messages: Membrane

6239:CELE T01H10.3
gene id: 6239:CELE_T01H10.3
uniprot id: Q22081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE T03D8.2
gene id: 6239:CELE_T03D8.2
uniprot id: Q9XTY5
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

6239:CELE E01H11.1
gene id: 6239:CELE_E01H11.1
uniprot id: G8JY36
uniprot id: P90980
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (PubMed:22593072). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (Probable). Through phosphorylation of unc-18 in the AFD thermosensory neuron, plays a role in regulating temperature-dependent locomotion (PubMed:22593072).
messages: Resistant to the acetylcholine esterase inhibitor Aldicarb (PubMed:22593072). Impairs temperature sensitivity, tolerating higher temperatures compared to wild-type (PubMed:22593072).

6239:CELE C10H11.1
gene id: 6239:CELE_C10H11.1
uniprot id: P91041
names: Similarity
messages: Belongs to the villin/gelsolin family.

6239:CELE Y43C5A.6
gene id: 6239:CELE_Y43C5A.6
uniprot id: L8E822
uniprot id: Q95Q25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
messages: Nucleus

6239:CELE K06A5.7
gene id: 6239:CELE_K06A5.7
uniprot id: O44552
names: Similarity
messages: Belongs to the MPI phosphatase family.

6239:CELE T25D3.4
gene id: 6239:CELE_T25D3.4
uniprot id: A0A0K3ARQ9
uniprot id: A0A0K3AX26
uniprot id: Q965I9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R07E4.6
gene id: 6239:CELE_R07E4.6
uniprot id: P30625
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons.
messages: Expressed at a low level during embryogenesis. Expression increases sharply approximately four hours before hatching with levels peaking during the first larval stage. Levels then decrease as development progresses to adulthood.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer that binds four cAMP molecules.
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear.
messages: cytosol

6239:CELE F26H11.2
gene id: 6239:CELE_F26H11.2
uniprot id: Q6BER5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPTF family.
messages: Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.
messages: Nucleus
messages: Part of a nucleosome remodeling factor-like (NURF-like) complex containing nurf-1 and isw-1.

6239:CELE F15A4.4
gene id: 6239:CELE_F15A4.4
uniprot id: O17819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C29H12.1
gene id: 6239:CELE_C29H12.1
uniprot id: Q18316
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE K02F2.6
gene id: 6239:CELE_K02F2.6
uniprot id: O44986
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE R13A1.4
gene id: 6239:CELE_R13A1.4
uniprot id: Q21974
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Expressed in puncta in dorsal D (DD) motor neurons and in adjacent DA and DB cholinergic motor neurons in the larval stage L1 ventral nerve cord.
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel (By similarity). Involved in the activity-dependent removal of selected presynaptic proteins, such as synaptobrevin snb-1, and Ras-related rab-3, in the remodeling of GABAergic motor neurons (PubMed:34045310).

6239:CELE Y92C3B.3
gene id: 6239:CELE_Y92C3B.3
uniprot id: Q8MXS1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Plays a role in apical endocytosis/recycling (PubMed:24843160). May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells (PubMed:24843160).
messages: RNAi-mediated knockdown results in disrupted clearance of intracellular pathogen N.parisii from intestinal cells.

6239:CELE Y15E3A.2
gene id: 6239:CELE_Y15E3A.2
uniprot id: Q9U2R5
names: Similarity
messages: Belongs to the globin family.

6239:CELE F14D7.6
gene id: 6239:CELE_F14D7.6
uniprot id: E0AHC0
uniprot id: L8E6P0
uniprot id: Q19453
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R13F6.4
gene id: 6239:CELE_R13F6.4
uniprot id: G5EGQ6
uniprot id: H1ZUX0
uniprot id: H1ZUX1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Isoform 1 is expressed in a cluster of cells in the anterior half at 2.5 hours post fertilization (hpf), in hypodermal cells at 5 hpf, in pharyngeal cells, intestinal and some neurons at 6 hpf. Isoform 1 is expressed in pharyngeal cells at L1 larval stage. Isoform 1 is expressed in somatic gonad precursor cells (SGPs) during the L2 larval stage. Isoform 2 is expressed in anterior neuronal cells and posterior hypodermal cells at 5 hpf, in neurons of the head at 7.6 hpf (at protein level). Expressed in somatic gonad founder cells Z1 and Z4, pharynx and muscles.
messages: Isoform 1 is mainly expressed in organs derived from the mesoderm, including the pharynx, vulva muscles, gonad distal tip cells, intestine and several tail neurons. Isoform 2 is mainly expressed in the organs derived from the ectoderm, including hypodermal cells, head ganglion neurons and tail neurons (at protein level).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons.
messages: Probably proteolytically processed to generate a N-terminal intracellular domain.
messages: Shows gonad disorganization, nerve cord defasciculation and defects in distal tip cell migration and axonal pathfinding. Shows local basement membrane deficiency and early gonad disruption.

6239:CELE Y44E3B.1
gene id: 6239:CELE_Y44E3B.1
uniprot id: H2L0N3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus
messages: RNAi-mediated knockdown decreases survival upon infection with P.aeruginosa.
messages: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Involved in responding to mitochondrial damage (PubMed:28662060). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:28662060).

6239:CELE F08A8.4
gene id: 6239:CELE_F08A8.4
uniprot id: O62139
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ATP (By similarity). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (By similarity). ATP binding likely occurs during acox-1.4 folding and/or dimer formation (By similarity).
messages: Belongs to the acyl-CoA oxidase family.
messages: Homodimer.
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:29537254, PubMed:29863473). Specifically, shortens ascarosides with a 9-carbon side chain (asc-C9) and, in association with acox-1.1, may contribute to the shortening of ascarosides with a 11-carbon side chain (asc-C11) (PubMed:29537254, PubMed:29863473). May contribute to the production of indol-3-carbonyl(IC)-ascarosides in association with acox-1.1 and acox-3 (PubMed:29863473).
messages: Peroxisome

6239:CELE T07G12.2
gene id: 6239:CELE_T07G12.2
uniprot id: O18061
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R11G10.2
gene id: 6239:CELE_R11G10.2
uniprot id: Q21950
names: Similarity
messages: Belongs to the selenium-binding protein family.

6239:CELE F46H5.2
gene id: 6239:CELE_F46H5.2
uniprot id: Q7Z1R2
names: Similarity
messages: Belongs to the FAM122 family.

6239:CELE K01D12.11
gene id: 6239:CELE_K01D12.11
uniprot id: G5EDZ7
names: Similarity
messages: Belongs to the FAX family.

6239:CELE F35E8.13
gene id: 6239:CELE_F35E8.13
uniprot id: G5EEU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F53C11.6
gene id: 6239:CELE_F53C11.6
uniprot id: Q93764
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y45F10C.4
gene id: 6239:CELE_Y45F10C.4
uniprot id: O45944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE F45G2.6
gene id: 6239:CELE_F45G2.6
uniprot id: G5EG80
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE M110.1
gene id: 6239:CELE_M110.1
uniprot id: Q21528
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE B0213.10
gene id: 6239:CELE_B0213.10
uniprot id: O44655
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F59C6.6
gene id: 6239:CELE_F59C6.6
uniprot id: Q93832
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F01E11.5
gene id: 6239:CELE_F01E11.5
uniprot id: Q19084
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the pharyngeal neurons, MCL/R and NSML/R and the AS group of amphidial sensory neurons, ASEL/R, AGSL/R, ASHL/R and ASIL/R.
messages: G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. Expression in amphidial sensory neurons suggests a role in chemosensation.

6239:CELE F52A8.4
gene id: 6239:CELE_F52A8.4
uniprot id: B3WFV1
uniprot id: Q20638
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F45E1.6
gene id: 6239:CELE_F45E1.6
uniprot id: Q10453
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Highly expressed in all adult nuclei.
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

6239:CELE Y11D7A.12
gene id: 6239:CELE_Y11D7A.12
uniprot id: Q9XWR1
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Expressed during embryogenesis and adulthood (at protein level) (PubMed:18794349). Expressed in most cells starting at gastrulation and diminishing by the L1 larval stage; however, also expressed in L4 larval stage and adults (PubMed:18794349).
messages: Knockout, in a flh-2 mutant background, causes poor coordination, egg-laying defects and dumpy appearance (PubMed:18794349). Causes a ninefold to 10-fold decrease in lin-14 level in embryos and about 2-fold increase in the levels of micro-RNAs lin-4 and mir-241 (PubMed:18794349). Despite the increase in lin-4 expression, post-embryonic heterochronic defects are not observed (PubMed:18794349). RNAi-mediated knockdown causes precocious embryonic expression of micro-RNA lin-4, exacerbated by simultaneous RNAi-mediated knockdown of flh-2 (PubMed:18794349).
messages: Probable transcription factor (PubMed:18794349). Binds to the DNA sequence motif 5'-[AG]GGCGCCG-3' in the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2 (PubMed:18794349).

6239:CELE K06A5.3
gene id: 6239:CELE_K06A5.3
uniprot id: O44550
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C52E4.5
gene id: 6239:CELE_C52E4.5
uniprot id: Q18788
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity).
messages: Membrane

6239:CELE F09E5.15
gene id: 6239:CELE_F09E5.15
uniprot id: A0A0K3AUJ9
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated following oxidation of the conserved redox-active cysteine residue, which subsequently allows for the oxidation and activation of substrates.
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Expressed in the gonad, neurons and intestine (at protein level) (PubMed:19064914). Expressed in the pharyngeal inter-neuron I4 and the sensory interneuron I2 (PubMed:15099742, PubMed:25640076). Expressed in the intestine, pharyngeal muscle 1, vulval muscle, body wall muscle, epithelial cells e1 and e3, and neurons in the head and tail (PubMed:25640076).
messages: Expressed throughout embryonic, larval and adult stages (PubMed:15099742, PubMed:19064914). Highly expressed at the L3 larval stage at 25 degrees Celsius (PubMed:29055282).
messages: Monomer and homodimer; disulfide-linked (PubMed:19064914). Under nonstress conditions, present in the reduced monomeric form (PubMed:19064914). Forms active hyperoxidized monomers and disulfide-linked homodimers upon oxidation by hydrogen peroxide (PubMed:19064914). Forms active oxidized homodimers in response to the drug metformin (PubMed:24889636).
messages: Reduced size, egg production and brood size (PubMed:15099742). Survival in response to heat and oxidative stress induced by peroxides is comparable to wild-type (PubMed:15099742). RNAi-mediated knockdown increases lifespan in response to the heavy metal arsenite (PubMed:25808059). RNAi-mediated knockdown increases expression of gcs-1 and further increases gcs-1 expression in response to the heavy metal arsenite (PubMed:19064914). RNAi-mediated knockdown increases the expression of isoform a of skn-1 in intestinal nuclei (PubMed:25808059).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15099742). In I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076). In the intestine, plays a role in protecting cells against oxidative stress by detoxifying peroxides such as hydrogen peroxide (PubMed:15099742, PubMed:19064914, PubMed:20649472). In addition, plays a role in the recovery from oxidative stress induced by hydrogen peroxide (PubMed:20649472). In its hyperoxidized form (induced by hydrogen peroxide), confers protection against heat stress (PubMed:19064914). However, has a low tendency for overoxidation during the normal lifespan (PubMed:20964547). Increases sensitivity to cytotoxity caused by metalloids and heavy metals such as arsenic and cadmium by playing a role in inhibiting the expression of phase II detoxification genes such as gcs-1 in intestinal cells (PubMed:19064914, PubMed:25204677). In addition, in response to arsenite, promotes the secretion of the insulin ligand daf-28 into the pseudocoelom, which negatively regulates the activities of daf-16 and skn-1 (PubMed:25808059). Plays a role in promoting longevity (PubMed:19064914, PubMed:24889636). Plays a role in the mitohormetic pathway by promoting the activation of pmk-1 in response to the drug metformin (PubMed:24889636).
messages: Up-regulated in response to the drug metformin.

6239:CELE C27D9.2
gene id: 6239:CELE_C27D9.2
uniprot id: Q18256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE H20J04.3
gene id: 6239:CELE_H20J04.3
uniprot id: Q9N5M0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F53H10.2
gene id: 6239:CELE_F53H10.2
uniprot id: Q20733
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.
messages: May be a component of a histone deacetylase complex containing saeg-2, saeg-1 and hda-2. May interact with egl-4.
messages: Nucleus
messages: Ubiquitously expressed.

6239:CELE T01D3.6
gene id: 6239:CELE_T01D3.6
uniprot id: G5EDT4
uniprot id: G5EEP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

6239:CELE F02E8.2
gene id: 6239:CELE_F02E8.2
uniprot id: Q19125
uniprot id: Q7JNX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE R04E5.10
gene id: 6239:CELE_R04E5.10
uniprot id: Q86DC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE F01E11.1
gene id: 6239:CELE_F01E11.1
uniprot id: Q19082
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE F55A11.3
gene id: 6239:CELE_F55A11.3
uniprot id: Q20798
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Reduced growth rate.
messages: The RING-type zinc finger is required for E3 ligase activity.

6239:CELE T07A9.9
gene id: 6239:CELE_T07A9.9
uniprot id: O44411
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Expressed from early embryonic stages through to adulthood.
messages: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size (PubMed:24552710). May regulate fat storage via the insulin/IGF pathway (PubMed:24552710).
messages: RNAi-mediated knockdown results in an extended lifespan, reduced brood size, slower growth rate and increased fat storage.
messages: Ubiquitously expressed.
messages: nucleolus

6239:CELE ZK484.2
gene id: 6239:CELE_ZK484.2
uniprot id: O44897
uniprot id: Q8IA64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

6239:CELE Y45F10D.12
gene id: 6239:CELE_Y45F10D.12
uniprot id: O45946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Cytoplasm

6239:CELE F14B6.6
gene id: 6239:CELE_F14B6.6
uniprot id: O62165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y38F2AR.7
gene id: 6239:CELE_Y38F2AR.7
uniprot id: G5EDB6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

6239:CELE F54D5.12
gene id: 6239:CELE_F54D5.12
uniprot id: G5EE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Peroxisome

6239:CELE W01C9.5
gene id: 6239:CELE_W01C9.5
uniprot id: A0A0K3ATU3
uniprot id: A0A0K3AU27
uniprot id: Q23117
names: Similarity
messages: Belongs to the globin family.

6239:CELE T21H3.3
gene id: 6239:CELE_T21H3.3
uniprot id: O16305
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
messages: Interacts (in the presence of Ca(2+)) with pde-1, madf-3, rpl-7A, tax-6, efk-1, npp-1, obr-4, sos-1, akt-1, unc-13, tag-196, ugt-48, nmy-2, F27D4.4, ddx-23, efa-6 and R11H6.4.
messages: This protein has four functional calcium-binding sites.

6239:CELE F58F6.4
gene id: 6239:CELE_F58F6.4
uniprot id: O44175
names: Similarity
messages: Belongs to the activator 1 small subunits family.

6239:CELE Y75B8A.1
gene id: 6239:CELE_Y75B8A.1
uniprot id: Q9XW88
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the abd-b homeobox family.
messages: Nucleus
messages: Probable transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification (PubMed:10781051, PubMed:21408209). May regulate expression of transcription factor dmd-3 (PubMed:21408209).
messages: RNAi-mediated knockdown in adults has no effect on their F1 progeny, but increases the frequency of posterior morphological abnormalities on a homeobox nob-1 mutant background (PubMed:10781051). However, RNAi-mediated knockdown in L1 larvae causes defects in tail tip morphogenesis, which are exacerbated on a nob-1 mutant background (PubMed:21408209).

6239:CELE C10H11.3
gene id: 6239:CELE_C10H11.3
uniprot id: P91039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE F33D11.12
gene id: 6239:CELE_F33D11.12
uniprot id: Q95X59
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE ZK616.10
gene id: 6239:CELE_ZK616.10
uniprot id: Q65XX7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed during embryogenesis (at protein level) (PubMed:20026024). First expressed shortly after the assembly of the gonad primordium (PubMed:15294864). Expressed in somatic gonadal precursor (SGP) cells in embryos and L1 stage larvae (PubMed:20026024, PubMed:24402584). Expressed in daughter cells of SGP cells throughout the L1 larval stage (PubMed:20026024).
messages: Nucleus
messages: RNAi-mediated knockdown results in abnormal gonadal development in 10% of animals whereby gonads fail to divide or grow in size (PubMed:15294864). This abnormality is enhanced in a tra-1 (e1099) mutant background and is accompanied by masculinization of gonadal tissues (PubMed:15294864).
messages: Required for proper gonadal primordium assembly and somatic gonad precursor cell morphology.
messages: Together with the zinc finger protein ztf-16, plays a role in gonadogenesis, specifically in somatic gonad precursor cell development (PubMed:12756172, PubMed:15294864, PubMed:20026024, PubMed:24402584). This is possibly by regulating tra-1 gene expression (PubMed:15294864).

6239:CELE B0454.1
gene id: 6239:CELE_B0454.1
uniprot id: G5EDW7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction.
messages: Belongs to the lin-8 family.
messages: Interacts with lin-35 (via C-terminus).
messages: Nucleus
messages: Temperature-sensitive multivulva phenotype in a lin-15B n2245 or lin-52 n771 mutant background.
messages: Widely expressed throughout development, with particularly prominent expression in the germline and in neuronal nuclei of the head (at protein level).

6239:CELE C51F7.2
gene id: 6239:CELE_C51F7.2
uniprot id: G5EF81
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C06G3.7
gene id: 6239:CELE_C06G3.7
uniprot id: Q17745
uniprot id: V6CLN2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Contains a selenide-sulfide bond between Cys-665 and Sec-666. This bond is speculated to serve as redox-active pair (By similarity).
messages: Cytoplasm
messages: Expressed in intestine, pharynx, seam cells, hypodermis, rectal epithelial cells, neurons in the nerve ring and amphid sheath cells.
messages: Homodimer.
messages: No obvious phenotype. RNAi-mediated knockdown of gsr-1 in mutants lacking trxr-1 causes an arrest during larval molting characterized by a partial detachment of the old cuticle and an impaired ability to reduce cuticle components. Also results in growth arrest during the postdauer molt.
messages: The active site is a redox-active disulfide bond.
messages: Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting.

6239:CELE F44G3.6
gene id: 6239:CELE_F44G3.6
uniprot id: G5EE67
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE F17C11.3
gene id: 6239:CELE_F17C11.3
uniprot id: Q19514
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE B0252.3
gene id: 6239:CELE_B0252.3
uniprot id: Q10917
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

6239:CELE K12F2.1
gene id: 6239:CELE_K12F2.1
uniprot id: P12844
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Essential for muscle contraction (PubMed:2583106). Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells (PubMed:17326220).
messages: Expressed in body wall muscles, neighboring vulval muscle cells and the contractile sheath covering the hermaphrodite gonad (myoepithelial sheath cells).
messages: Expression at early and late larval stages is 1:20 of unc-54 (mhc b), however later at L1 and L4 expression is more equal at 1:1.7 and 1:3.1 respectively.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: Worms exhibit retarded embryonic development and paralysis (PubMed:2583106). Muscle organization shows disruption with abnormalities of both the filament lattice that constitutes the A-band and the hypodermal cell (PubMed:2583106). RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 51 percent of animals (PubMed:17326220).
messages: myofibril

6239:CELE Y59E9AR.5
gene id: 6239:CELE_Y59E9AR.5
uniprot id: Q9N2K7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Alters embryonic vab-7 expression pattern.
messages: Involved in the regulatory network to control embryonic patterning and morphogenesis. Implicated in negatively regulating vab-7 expression at the anterior of embryos.
messages: Nucleus

6239:CELE Y17G9B.3
gene id: 6239:CELE_Y17G9B.3
uniprot id: Q9N574
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C40D2.4
gene id: 6239:CELE_C40D2.4
uniprot id: O76560
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F10E7.7
gene id: 6239:CELE_F10E7.7
uniprot id: P49180
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

6239:CELE Y71G12B.24
gene id: 6239:CELE_Y71G12B.24
uniprot id: Q95XN2
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the peptidase M16 family, lacks the zinc-binding sites and appears to lack catalytic activity in vitro.
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of mppa-1 (alpha) and mppb-1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which mppa-1 is involved in substrate recognition and binding and mppb-1 is the catalytic subunit.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown causes 63 percent embryonic lethality (PubMed:16788047). Embryonic lethality is further increased in simultaneous RNAi-mediated knockdown of mppa-1 and mppb-1 or ucr-1 and mppa-1 (PubMed:16788047).
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

6239:CELE F46F3.2
gene id: 6239:CELE_F46F3.2
uniprot id: P90876
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C25A1.7
gene id: 6239:CELE_C25A1.7
uniprot id: E2JL04
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE ZK430.8
gene id: 6239:CELE_ZK430.8
uniprot id: Q23490
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peroxidase family.
messages: Expressed in all adult and larval stages. Expression is cyclical and coincides with each of the larval molts, peaking at 12, 18, 24, and 30 hours post-hatching.
messages: Expressed in the hypodermal cells, specifically the head and seam/body.
messages: Gross morphological abnormalities causing larval arrest with associated molt defects and low levels of embryonic lethality. Cuticle function and integrity are also impaired.
messages: Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.

6239:CELE R11A8.2
gene id: 6239:CELE_R11A8.2
uniprot id: Q21924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

6239:CELE H05B21.4
gene id: 6239:CELE_H05B21.4
uniprot id: O61971
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y47G6A.20
gene id: 6239:CELE_Y47G6A.20
uniprot id: Q9N3S4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation (Probable). Ensures the correct splicing of genes involved in immunity to promote longevity in response to infection by pathogenic bacteria such as S.aureus (PubMed:32538777).
messages: Nucleus
messages: RNAi-mediated knockdown increases survival following infection by pathogenic bacteria S.aureus (PubMed:32538777). RNAi-mediated knockdown impairs the splicing of genes such as prg-2 and tos-1 following infection by S.aureus (PubMed:32538777). RNAi-mediated knockdown induces the expression of nlp-34, lys-3, irg-2, irg-1, M01G12.9, fmo-2 and cyp-37B1 under non-infected conditions (PubMed:32538777). RNAi-mediated knockdown increases the phosphorylation of pmk-1 (PubMed:32538777).
messages: The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions.

6239:CELE F46A9.3
gene id: 6239:CELE_F46A9.3
uniprot id: Q564V7
uniprot id: Q93732
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y38F2AR.10
gene id: 6239:CELE_Y38F2AR.10
uniprot id: Q95XR9
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y37E3.3
gene id: 6239:CELE_Y37E3.3
uniprot id: Q9GR61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).
messages: Nucleus

6239:CELE T20F7.7
gene id: 6239:CELE_T20F7.7
uniprot id: O02171
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F11A10.3
gene id: 6239:CELE_F11A10.3
uniprot id: Q19336
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex.
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, throughout development (By similarity). Required for ubiquitination of histone H2A (PubMed:19211678). Plays a role in the formation of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:19211678). Required for normal migration of the hermaphrodite specific neurons (HSN) and for extension of some neuronal processes (PubMed:19211678). Represses vulval fates in hypodermal cells that do not normally contribute to vulval development (PubMed:19211678).
messages: Expression begins early in embryogenesis and continues in larval development and into adulthood of males and hermaphrodites.
messages: Nucleus
messages: Viable, but has defects in the male-specific genital sensilla (simple sense organs) known as rays (PubMed:19211678). Defects in the migration and axon extension of the hermaphrodite specific neurons (HSN) during embryogenesis (PubMed:19211678). Ubiquitin-modified histone H2A is not detected in mutants (PubMed:19211678). RNAi-mediated knockdown in a lin-15 mutant background causes a multiple vulva (Muv) phenotype (PubMed:19211678).
messages: nucleolus

6239:CELE R11A5.1
gene id: 6239:CELE_R11A5.1
uniprot id: O45718
uniprot id: O62348
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

6239:CELE F41H10.11
gene id: 6239:CELE_F41H10.11
uniprot id: Q9BI89
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

6239:CELE R05H5.1
gene id: 6239:CELE_R05H5.1
uniprot id: Q21767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane
messages: Thought to be a chemosensory receptor.

6239:CELE C32F10.1
gene id: 6239:CELE_C32F10.1
uniprot id: O01686
names: Similarity
messages: Belongs to the OSBP family.

6239:CELE Y53G8B.1
gene id: 6239:CELE_Y53G8B.1
uniprot id: Q9N4S0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

6239:CELE T05C12.5
gene id: 6239:CELE_T05C12.5
uniprot id: Q22226
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

6239:CELE T27E4.8
gene id: 6239:CELE_T27E4.8
uniprot id: P34696
names: Induction
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat stress.

6239:CELE C36E6.5
gene id: 6239:CELE_C36E6.5
uniprot id: P19626
names: Miscellaneous
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: This chain binds calcium.

6239:CELE ZK1098.10
gene id: 6239:CELE_ZK1098.10
uniprot id: P34609
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the JIP scaffold family.
messages: Expressed in neurons of the ventral cord, retrovesicular and preanal ganglia and nerve ring, intestinal cells, seam and hypodermal cells, body wall, head muscle and pharynx.
messages: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons (PubMed:30880001).
messages: perinuclear region

6239:CELE R12A1.4
gene id: 6239:CELE_R12A1.4
uniprot id: Q04457
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears in mid-proliferation phase when the developing gut has four to eight cells.
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Endoplasmic reticulum lumen
messages: Expressed only in the intestine.

6239:CELE F55A4.8
gene id: 6239:CELE_F55A4.8
uniprot id: A8WFM4
uniprot id: H2KYF2
uniprot id: Q8MPU6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48A5A.1
gene id: 6239:CELE_Y48A5A.1
uniprot id: Q9TYM6
names: Function
names: Similarity
messages: Belongs to the SHQ1 family.
messages: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs).

6239:CELE Y44A6D.5
gene id: 6239:CELE_Y44A6D.5
uniprot id: Q9XXD8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

6239:CELE K11E8.1
gene id: 6239:CELE_K11E8.1
uniprot id: G5EDZ5
uniprot id: O62305
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria (PubMed:23325232, PubMed:23505381). Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Ca2(+)/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca(2+)/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca(2+) pulses to become Ca(2+) independent.
messages: Cytoplasm
messages: Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983). Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946). Interacts with nsy-1 (PubMed:11336672).
messages: Expressed in the nervous system. Observed in the ADF and AWC neurons. Position in AWC neurons is regulated by microtubules. Localized to clusters in ventral cord neurites which appear to be required for glr-1 trafficking. Also present in oocytes.
messages: Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release.
messages: Perikaryon
messages: axon

6239:CELE K09C8.4
gene id: 6239:CELE_K09C8.4
uniprot id: Q21389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Golgi apparatus membrane
messages: Probable glycosyltransferase.

6239:CELE R07G3.5
gene id: 6239:CELE_R07G3.5
uniprot id: Q09422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity.
messages: Interacts with skn-1 isoforms a and c.
messages: Mitochondrion outer membrane

6239:CELE F41C6.5
gene id: 6239:CELE_F41C6.5
uniprot id: Q20270
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y53F4B.12
gene id: 6239:CELE_Y53F4B.12
uniprot id: Q9NAB9
uniprot id: U4PLX3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C44B11.3
gene id: 6239:CELE_C44B11.3
uniprot id: P91910
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Specifically expressed in neurons.
messages: Touch insensitive phenotype, which may be due to defective touch receptor neuron synaptic transmission.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Component of the large-diameter neuronal microtubules which contains 15 protofilaments (PubMed:9885292). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:9885292, PubMed:19652181).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.

6239:CELE C42D8.5
gene id: 6239:CELE_C42D8.5
uniprot id: Q18581
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase M2 family.
messages: Expressed in embryos and larvae (PubMed:14559923). Expressed in an oscillating expression pattern during larval development, with low expression at the L2 stage, high expression at the L2/L3 transition and low expression at the L3 stage (PubMed:28933985).
messages: Expressed in the hypodermis, in the vulva during organogenesis, and in the ray papillae of the male tail.
messages: Inactive as a metallopeptidase, due to a lack of active site residues (PubMed:14559923). Required for larval molting, male tail development, and formation of adult alae (PubMed:14559923). Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production (PubMed:28933985). Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events (PubMed:28933985). Might act downstream of the heterochronic protein lin-41 (PubMed:28933985). Negative regulator of lifespan, heat and oxidative stress response and age-related degenerative changes like reduced pharyngeal pumping and decreased body movements (PubMed:26918946). Lifespan restriction is dependent on the forkhead-type transcription factor daf-16 (PubMed:26918946).
messages: RNAi-mediated knockdown results in the extension of mean and maximum lifespan of 21% and 18%, respectively, and increased resistance to oxidative stress caused by paraquat (PubMed:26918946). RNAi-mediated knockdown in a daf-16 mutant background shortens mean and maximum lifespan by 3% and 2%, respectively (PubMed:26918946). RNAi-mediated knockdown in a let-7 mutant background partially suppresses the retarded and supernumerary hypodermal seam cell divisions, retarded alae production and postembryonic lethality (PubMed:28933985). Double RNAi-mediated knockdown with apl-1 in a let-7 mutant phenotype leads to complete suppression of the heterochronic seam cell defects (PubMed:28933985).

6239:CELE C14C6.2
gene id: 6239:CELE_C14C6.2
uniprot id: A0A0K3AVD0
uniprot id: O44675
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y113G7A.6
gene id: 6239:CELE_Y113G7A.6
uniprot id: Q9U2Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed in the bilateral AFD neurons as well as in the nine pharyngeal marginal cells (PubMed:11580895). Expressed in amphid sheath AMsh and phasmid sheath PHsh glia (PubMed:21350017).
messages: Nucleus
messages: Probable transcription factor (PubMed:21350017, PubMed:25614239). Binds to a motif including the sequence 5'-TAA[TG]-3' in regulatory promoter elements (PubMed:21350017, PubMed:25614239). Modulates expression of its own, and of various other, genes in the AFD thermosensory neurons or AMsh amphid sheath glia, incuding the nuclear hormone receptor nhr-38, the LIM homeobox ceh-14, cyclic nucleotide-gated channel tax-2, receptor-type guanylyl cyclase gcy-8 and VEGF-related protein ver-1 (PubMed:11580895, PubMed:21350017, PubMed:25614239). Required for the development and cell fate of AFD neurons (PubMed:11580895, PubMed:21350017, PubMed:22298710). In concert with ceh-14, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating gcy-8, gcy-18 and other genes (PubMed:25614239). Involved in thermosensory behavior, thereby regulating entry and exit into the dauer larval stage of development (PubMed:11580895). Required in amphid sheath AMsh glia remodeling during entry into dauer stage, acting by positively regulating the expression of ver-1 in AMsh of amphid sensory neurons (PubMed:21350017, PubMed:22298710). May be essential for early development (PubMed:22298710).

6239:CELE F57C2.3
gene id: 6239:CELE_F57C2.3
uniprot id: O45595
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: Telomeric DNA-binding protein, which binds to two or more single-stranded G-rich repeat sequences (G-strand), with high specificity to the 5'-TTAGGC-3' sequence (PubMed:18329362, PubMed:23390606). In addition, repeat sequence binding requires a 3' single-stranded telomeric overhang (PubMed:18329362). Acts redundantly with pot-1 to negatively regulate telomerase-mediated telomere extension (PubMed:18329362, PubMed:23390606, PubMed:24297748). Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres) (PubMed:23390606, PubMed:22547822, PubMed:24297748). Does not appear to have a role in anchoring telomeres to the nuclear envelope (PubMed:24297748).
messages: telomere

6239:CELE W01D2.5
gene id: 6239:CELE_W01D2.5
uniprot id: Q9XU63
uniprot id: U4PEW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter.

6239:CELE C48B6.3
gene id: 6239:CELE_C48B6.3
uniprot id: O01512
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C03G5.1
gene id: 6239:CELE_C03G5.1
uniprot id: Q09508
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

6239:CELE C02D5.2
gene id: 6239:CELE_C02D5.2
uniprot id: P34276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Membrane

6239:CELE K02G10.5
gene id: 6239:CELE_K02G10.5
uniprot id: X5LV99
uniprot id: X5M903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

6239:CELE K03A1.1
gene id: 6239:CELE_K03A1.1
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE B0207.4
gene id: 6239:CELE_B0207.4
uniprot id: O01427
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Component of the CPC complex which consists of icp-1; csc-1; bir-1 and air-2 (PubMed:12707312). Within the complex, interacts with icp-1; csc-1 and bir-1 (PubMed:12707312, PubMed:11050385). Interacts with zen-4 (PubMed:11050384). Interacts with tlk-1 and bmk-1 (PubMed:15548597, PubMed:15916946).
messages: Midbody
messages: Phosphorylated. Increased phosphorylation upon chromatin obstructions at anaphase.
messages: Present during gametogenesis and throughout embryogenesis (at protein level).
messages: RNAi-mediated knockdown disrupts the localization of the condensin subunit smc-4 to mitotic chromosomes (PubMed:11914278). RNAi-mediated knockdown causes failure in mitotic chromosome segregation and cytokinesis, leading to aneuploidy (PubMed:11914278, PubMed:12213836).
messages: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:12707312, PubMed:11050385, PubMed:10983970, PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation (PubMed:12707312, PubMed:10983970). Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis (PubMed:18923084). Required for histone H3 'Ser-10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116, PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-680'(PubMed:15854913). Required for the recruitment of bub-1 to the ring-shaped domain between chromosomes during meiotic anaphase I (PubMed:20729837). Also required for the localization of the condensin I complex subunit smc-4 to mitotic chromosomes (PubMed:11914278). Acts at the spindle midzone and the midbody to prevent cleavage furrow regression upon chromatin obstructions during cytokinesis (PubMed:12213836, PubMed:23684975).
messages: cytoskeleton
messages: spindle

6239:CELE F47C10.3
gene id: 6239:CELE_F47C10.3
uniprot id: A0A163VU66
uniprot id: O01561
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE R13H4.4
gene id: 6239:CELE_R13H4.4
uniprot id: A5JYX3
uniprot id: I7LFF2
uniprot id: P90947
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the vinculin/alpha-catenin family.
messages: Component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (Probable). May interact with hmp-2 (PubMed:11560894).
messages: Cytoplasm
messages: Epidermal cells.
messages: Present in all embryonic blastomeres at early stages of development.
messages: Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Required for proper localization of other junctional components, such as pac-1 (PubMed:25938815).
messages: Worms arrest their elongation at the 1.25X to 1.5X stage.
messages: adherens junction

6239:CELE K02G10.1
gene id: 6239:CELE_K02G10.1
uniprot id: Q21161
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE Y57A10B.5
gene id: 6239:CELE_Y57A10B.5
uniprot id: Q9XWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F08G12.4
gene id: 6239:CELE_F08G12.4
uniprot id: Q19213
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VHL family.
messages: Increased mortality induced by B.thuringiensis pore-forming toxins Cry21A and Cry21B (PubMed:20011506). Increased mortality and sensitivity to paralysis induced by enteropathogenic E.coli infection (PubMed:16091039). Increased mortality upon heat stress (PubMed:12686697). RNAi-mediated knockdown causes an enhanced resistance to polyglutamine or amyloid-beta-mediated paralysis and an increase in adult life span.
messages: Interacts with hif-1 (hydroxylated on 'Pro-621'); the interaction induces hif-1 degradation (PubMed:11595184). May be a component of the cullin E3 ubiquitin ligase complex (By similarity).
messages: Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%) (PubMed:11595184). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size (PubMed:12686697, PubMed:19372390, PubMed:22396654). Mediates resistance to enteropathogenic E.coli (PubMed:16091039). Mediates susceptibility to B.thuringiensis pore-forming toxins (PubMed:20011506). Not involved in P.aeruginosa susceptibility (PubMed:20865124).

6239:CELE C32A3.1
gene id: 6239:CELE_C32A3.1
uniprot id: Q09260
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a complex consisting of at least a lin-12/Notch intracellular domain (NICD), lag-1, and lag-3 (PubMed:10830967, PubMed:16530045). Interacts with a NICD of lin-12/Notch or glp-1/Notch; the interactions are direct (PubMed:10830967, PubMed:16530045).
messages: Expressed in the progenitor zone and the early pachytene region of the hermaphrodite gonad.
messages: Nucleus
messages: RNAi-mediated knockdown causes multiple defects, including large vulval protrusions in hermaphrodites, premature differentiation of germ cells as sperm, and embryonic arrest around the onset of morphogenesis (PubMed:10884418). RNAi-mediated knockdown causes a partial decrease in apoptosis in germ line cells, in the F1 generation, induced by gamma-irradiation (PubMed:17317671). RNAi-mediated knockdown, during treatment by gamma-irradiation, reduces the expression of the p53 target genes, ced-13 and egl-1 (PubMed:17317671).
messages: glp-1/Notch and lin-12/Notch proteins promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator, probably as part of a complex with a Notch intracellular domain (NICD) and the transcription regulator lag-1 (PubMed:10830967, PubMed:10884418, PubMed:16530045). Involved in the p53-mediated germ-cell apoptotic response to DNA damage, perhaps acting as a transcriptional activator (PubMed:17317671). May regulate phosphatase lip-1 mRNA transcription downstream of glp-1 (PubMed:16319922).

6239:CELE C13D9.8
gene id: 6239:CELE_C13D9.8
uniprot id: O16242
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Expressed in the seam cells of the organism. Expression is visible in the seam cells across all larval stages, and expression persists into the adult stage of the organism.
messages: Inhibited by the sodium/calcium exchanger inhibitor CGP-37157.
messages: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC-dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit (PubMed:28196860).
messages: Mitochondrion inner membrane

6239:CELE C44B9.5
gene id: 6239:CELE_C44B9.5
uniprot id: Q18606
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T08D10.1
gene id: 6239:CELE_T08D10.1
uniprot id: G5EEG1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the nfya-1-NF-Y complex, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492). May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (Probable). With the components in this complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head (PubMed:17574230). May regulate egl-5 expression in association with the mes-2-mes-3-mes-6 complex (PubMed:17574230).
messages: Expressed at all developmental stages (PubMed:15704008, PubMed:17574230). In larvae, highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail, while expression in most somatic cells is weak (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008).
messages: Expressed in certain parts of the gonads with high expression in fertilized oocytes in the uterus and mature oocytes from the distal to the proximal arm of the gonad, but weak expression in the syncytial ovaries and immature oocytes at the beginning of the proximal arm of the gonad (PubMed:15704008). Highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail (PubMed:17574230). Weakly expressed in most somatic cells (PubMed:17574230). Not expressed in the intestine, the hypodermis, body wall muscle surrounding the pseudocoelomic space, secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008).
messages: Forms a heterotrimeric transcription factor complex (nfya-1-NF-Y complex) composed of nfya-1, nfyb-1 and nfyc-1, which binds to 5'-CCAAT-3' box motif in the promoters of its target genes (PubMed:17574230). Interacts with the nfyb-1 and nfyc-1 dimer; the interaction is required for subsequent binding to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230). Does not interact with either nfyb-1 or nfyc-1 in their monomeric form (PubMed:17574230). Interacts with mes-3 (PubMed:17574230).
messages: Nucleus
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region of hermaphrodites (PubMed:17574230). RNAi-mediated knockdown results in morphological defects in the male tail due to cell transformation defects whereby anterior seam cells adopt a posterior seam cell fate, which is indicated by ectopic expression of the ray-specific protein pkd-2 in the anterior mid-body region (PubMed:17574230). This leads to impaired cell identities of the rays derived from seam cells (PubMed:17574230). These animals also have defective cell transformations in the ventral cord and generate two extra serotonergic CP neurons (PubMed:17574230). RNAi-mediated knockdown results in ectopic expression of tbx-2 in the gut and seam cells of L4 stage larvae and adults (PubMed:23933492).

6239:CELE C42C1.19
gene id: 6239:CELE_C42C1.19
uniprot id: A3QMC7
uniprot id: C0RSI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

6239:CELE F09F3.10
gene id: 6239:CELE_F09F3.10
uniprot id: P90822
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y45G12B.2
gene id: 6239:CELE_Y45G12B.2
uniprot id: Q9N4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Membrane

6239:CELE T21B10.5
gene id: 6239:CELE_T21B10.5
uniprot id: A0A163UT06
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Broadly expressed in tissues at the L1 larval stage (PubMed:29702639). In the male germline, first expressed in primary spermatocytes at the L4 larval stage and expression increases as spermatocyte differentiation progresses (PubMed:29702639).
messages: Expressed in the germline (PubMed:29702639). Predominantly expressed in primary spermatocytes (PubMed:29702639). Also expressed in the oocyte-producing germline of hermaphrodites (PubMed:29702639).
messages: Histone methyltransferase that specifically mono- and di-methylates 'Lys-4' of histone H3 in vitro (PubMed:24685137). Does not tri-methylate 'Lys-4' of histone H3 in vitro (PubMed:24685137). Promotes spermatid development and fertility by positively regulating the transcription of spermatocyte-specific genes in primary spermatocytes (PubMed:29702639). Together with spr-5, required for transgenerational fertility (PubMed:24685137).
messages: Nucleus
messages: RNAi-mediated knockdown partially suppresses the sterility of spr-5 mutants (by101) and results in a slightly increased number of eggs laid as compared to the spr-5 single mutant.

6239:CELE K02B2.4
gene id: 6239:CELE_K02B2.4
uniprot id: Q21123
uniprot id: V6CLI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C55H1.2
gene id: 6239:CELE_C55H1.2
uniprot id: Q9BIG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE Y39G10AR.2
gene id: 6239:CELE_Y39G10AR.2
uniprot id: Q95XP9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex composed of rod-1, czw-1 and zwl-1 (PubMed:18765790). Interacts with the spindly-like protein spdl-1 (PubMed:18765790). Interacts with NDC80 complex component ndc-80 (PubMed:24231804).
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:18765790). Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:18765790, PubMed:19109417).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:18765790, PubMed:19109417). RNAi-mediated knockdown results in defective chromosome segregation, premature spindle pole separation and incorrectly attached kinetochores (PubMed:18765790). In addition, knl-1 localization to the spindle-associated rod-shaped structures but not to kinetochores is lost during anaphase of meiosis I (PubMed:20729837). RNAi-mediated knockdown also results in abolished targeting of the spindly-like protein spdl-1 to the kinetochore (PubMed:18765790).
messages: cell cortex
messages: kinetochore
messages: spindle

6239:CELE Y47D3A.16
gene id: 6239:CELE_Y47D3A.16
uniprot id: Q9NAH6
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: May be phosphorylated on Thr-404 by let-363/TOR.
messages: Perikaryon
messages: RNAi-mediated knockdown causes an increased lifespan and resistance to starvation, slower growth and a decrease in brood size (PubMed:17266680). Causes a decrease in the number of germline progenitors (PubMed:22278922). RNAi-mediated knockdown in adults causes increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown in a daf-2 e1370 mutant background results in daf-16-mediated up-regulation of stdh-1 reporter expression in the intestine and a synergistic increase in lifespan. RNAi-mediated knockdown in germ line, hypodermis and to a lesser extent in intestine and daf-2 e1370 mutant background causes a synergistic increase in lifespan (PubMed:24332851).
messages: Serine/threonine-protein kinase which regulates mRNA translation (PubMed:17266680). Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection (PubMed:17266680, PubMed:23879233, PubMed:24332851). May regulate these processes by preventing the activation of transcription factor hif-1 (PubMed:23879233). Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size (PubMed:22278922). In addition required for sperm production and embryo viability (PubMed:17266680, PubMed:22278922). Involved in axon regeneration of PLM and ALM neurons by inhibiting growth cone formation early after axotomy and later by inhibiting axon extension. Functions in axon regeneration and lifespan probably by preventing aak-2/AMPK activation (PubMed:24332851, PubMed:24431434). Negatively regulates autophagy (PubMed:22560223).
messages: axon

6239:CELE C50F7.10
gene id: 6239:CELE_C50F7.10
uniprot id: Q18758
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

6239:CELE C26E6.9
gene id: 6239:CELE_C26E6.9
uniprot id: Q18221
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2.
messages: Expressed in all cells of embryo. In L1 larva, it is predominantly expressed in Z2 and Z3 primordial germ cells. In adults, it is predominantly expressed in the germline.
messages: Expressed throughout embryogenesis.
messages: Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells (PubMed:21527717, PubMed:20555324). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:21527717). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:20555324, PubMed:28379943). Methylation in the germline is required for germline development and fertility, possibly by ensuring genome stability (PubMed:21527717, PubMed:12242227). May act redundantly with mes-3 and mes-4 proteins in the development of a fertile germline (PubMed:11729150). Required for RNAi (PubMed:17967446). Functions as an antagonist of hpl-1 and hpl-2 activity in growth and somatic gonad development (PubMed:17967446). Cooperates with jmjd-3.1 and egl-27 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Nucleus
messages: RNAi-mediated knockdown results in disruption of invariant Y-to-PDA transdifferentiation (PubMed:25124442). Results in decreased trimethylation at 'Lys-4' of histone H3 (PubMed:20555324). Leads to an extension of lifespan (PubMed:20555324). Leads to a deregulation of fat metabolism and to an enrichment of mono-unsaturated fatty acids (PubMed:28379943).

6239:CELE W04D2.3
gene id: 6239:CELE_W04D2.3
uniprot id: Q23157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C25A6.1
gene id: 6239:CELE_C25A6.1
uniprot id: Q4R171
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE Y32B12A.3
gene id: 6239:CELE_Y32B12A.3
uniprot id: Q9XXH0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE C28C12.10
gene id: 6239:CELE_C28C12.10
uniprot id: X5LX76
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Activates cdc-42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP (By similarity). May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Required for normal lifespan (PubMed:36173858).
messages: RNAi-mediated knockdown reduces lifespan.
messages: cytoskeleton

6239:CELE F07A11.5
gene id: 6239:CELE_F07A11.5
uniprot id: Q19133
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

6239:CELE ZK328.4
gene id: 6239:CELE_ZK328.4
uniprot id: Q23462
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the serine-aspartate repeat-containing protein (SDr) family.
messages: Chromosome
messages: Interacts with top-2; this interaction allows the resolution of topoisomerase II (top-2) DNA-protein cross-links.
messages: Mainly expressed in germ cells and early embryonic, proliferating cells.
messages: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427, PubMed:31839537, PubMed:31839538). May resolve the topoisomerase II (top-2) DPCs (PubMed:31839537, PubMed:31839538). Limits replication stress and DNA double-strand breaks (PubMed:31839537).
messages: Mutant worms become hypersensitive to formaldehyde-induced DNA damage (PubMed:30914427). Mutant worms exhibit significant reduction in brood size at 25 degrees Celsius and also exhibit a high incidence of male progeny at both 20 and 25 degrees Celsius (PubMed:27718356, PubMed:31839537). Moreover, exhibit a mortal germline (MRT) phenotype characterized by transgenerational loss of fecundity and vitality, marked by reduced lifespan, decreased mobility, and loss of fertility in later generations (PubMed:31839537). Mutants have a mortal germline, where brood sizes become progressively smaller and the population fails to survive beyond 12 generations (PubMed:31839538).

6239:CELE T09E8.1
gene id: 6239:CELE_T09E8.1
uniprot id: G5EEK3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Deletion results in slower embryonic development, mutants that are 5% shorter than their wild-type conterparts, and also leads to the prevention of nuclear migration in the embryonic epidermis (PubMed:26371552, PubMed:26586219). RNAi-mediated knockdown results in fragmentation of the cadherin-based junctional complex in embryos and intermediate filaments display a diffuse pattern in older embryos (PubMed:26586219). RNAi-mediated knockdown of isoform h results in disrupted germline architecture and sterility (PubMed:26371552).
messages: Directs the assembly of non-centrosomal microtubule arrays that determine the position of nuclei within intracellular compartments in the epidermis and this is independent of ptrn-1 activity.
messages: First expressed in between seam cells at the lima-bean stage of embryogenesis (PubMed:26586219). Expressed in the embryonic epidermis and in puncta in the epidermal syncytium and also in between the epidermal body syncytium and the seam cells of larvae (PubMed:26371552).
messages: Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis (PubMed:26371552). Required for microtubule stability and anchorage by binding to microtubule minus ends (PubMed:26371552). Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules (PubMed:26586219).
messages: Required for normal nuclear migration in the embryonic epidermis.
messages: adherens junction
messages: cytoskeleton
messages: hemidesmosome

6239:CELE Y25C1A.7
gene id: 6239:CELE_Y25C1A.7
uniprot id: H2KY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane

6239:CELE T22D1.4
gene id: 6239:CELE_T22D1.4
uniprot id: Q9GZH4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal (PubMed:23691084). Embryos exhibit cytokinesis defects which lead to arrest during development (PubMed:23691084). Embryogenesis proceeds more slowly and embryos are osmo-sensitive (PubMed:23691084). Defective localization of the yolk receptor rme-2 and impaired yolk secretion (PubMed:23691084). May result in chromosome segregation defects (PubMed:23691084).
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE ZC21.2
gene id: 6239:CELE_ZC21.2
uniprot id: P34586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
messages: Could mediate calcium entry and form a calcium permeant channel.
messages: Membrane

6239:CELE F32D8.13
gene id: 6239:CELE_F32D8.13
uniprot id: I2HAD9
names: Subcellular Location Annotation
messages: cytosol

6239:CELE D1014.1
gene id: 6239:CELE_D1014.1
uniprot id: Q18924
names: Similarity
messages: Belongs to the sulfatase family.

6239:CELE F11A5.9
gene id: 6239:CELE_F11A5.9
uniprot id: O17785
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K07G5.5
gene id: 6239:CELE_K07G5.5
uniprot id: Q21304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE ZK622.1
gene id: 6239:CELE_ZK622.1
uniprot id: Q23554
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE M88.1
gene id: 6239:CELE_M88.1
uniprot id: Q21603
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y48E1C.1
gene id: 6239:CELE_Y48E1C.1
uniprot id: G5EBV2
uniprot id: G5EC81
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

6239:CELE ZK131.4
gene id: 6239:CELE_ZK131.4
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE D1025.2
gene id: 6239:CELE_D1025.2
uniprot id: O62122
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE T10F2.5
gene id: 6239:CELE_T10F2.5
uniprot id: G4SNB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

6239:CELE T26C11.1
gene id: 6239:CELE_T26C11.1
uniprot id: Q22813
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK970.2
gene id: 6239:CELE_ZK970.2
uniprot id: Q27539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S14 family.
messages: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
messages: Expressed in the intestine.
messages: Mitochondrion matrix
messages: Tetradecamer that assembles into a two heptameric rings with a central cavity.

6239:CELE C29E4.1
gene id: 6239:CELE_C29E4.1
uniprot id: P34340
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE D2023.4
gene id: 6239:CELE_D2023.4
uniprot id: O17731
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur (PubMed:15283700). Substrate specificity: thialysine > O-(2-aminoethyl)-L-serine > S-(2-aminoethyl)-D,L-homocysteine (PubMed:15283700). Does not act on polyamines, such as spermidine and spermine, nor on diamines putrescine and cadaverine (PubMed:15283700).
messages: Homodimer.

6239:CELE R02D5.6
gene id: 6239:CELE_R02D5.6
uniprot id: K8ESD2
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T28D6.2
gene id: 6239:CELE_T28D6.2
uniprot id: O18154
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE C01A2.7
gene id: 6239:CELE_C01A2.7
uniprot id: G3MU46
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the ventral and dorsal nerve cords and ventral nerve cord motor neurons (PubMed:30779740). Also expressed in tail neurons and head neurons including SAB and DBI motor neurons (PubMed:30779740).
messages: Neuropeptide ligand for the G-protein coupled receptor sprr-2.
messages: Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning.
messages: Secreted

6239:CELE Y40B10A.1
gene id: 6239:CELE_Y40B10A.1
uniprot id: Q3LFN1
uniprot id: Q965W1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE F11A10.5
gene id: 6239:CELE_F11A10.5
uniprot id: Q19337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

6239:CELE Y48G8AR.1
gene id: 6239:CELE_Y48G8AR.1
uniprot id: G5EDF0
uniprot id: W6RT88
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. Grainyhead subfamily.
messages: Earliest expression is in elongating embryos (PubMed:36688410). Expressed in embryos, larvae and adults (PubMed:12888489). Expressed in larvae in various cell types, including seam cells, vulva precursor cells, non-seam hypodermal cells, pharyngeal cells, and head neurons (PubMed:36688410). Expressed rhythmically, reaching peak levels just prior to each molt (PubMed:36688410). Expression diminishes, or is absent, in some tissues in adults (PubMed:36688410).
messages: Nucleus
messages: Probable transcription factor (PubMed:12888489, PubMed:36688410). Binds a motif with the core sequence 5'-C[ACT][TG]G-3' in regulatory elements of target genes (PubMed:12888489, PubMed:36688410). Many putative target genes show oscillating expression levels, perhaps as a result of rhythmic variation in accumulation of grh-1 (PubMed:36688410). Plays a role in proper cuticle formation and/or barrier function and is required repetitively during development, for successful completion of each molt (PubMed:36688410). Involved in modulating lifespan (PubMed:35013237). Plays a role in defense response to bacteria (PubMed:35013237). May act upstream of the p38 MAP kinase / pmk-1 pathway (PubMed:35013237). May act downstream of the insulin/IGF-1 receptor signaling (IIS) pathway (PubMed:35013237).
messages: RNAi-mediated or conditional knockdown result in defective cuticle formation (PubMed:12888489, PubMed:36688410). RNAi-mediated knockdown in L4 stage larvae has no effect, but upon reaching adulthood, over 95% of the embryos produced by these animals arrest and fail to hatch (PubMed:12888489). Development arrests at the three-fold stage, showing abnormal constrictions or puckering in the external cuticle and approximately 8% of embryos exhibit ruptures in their cuticles resulting in the extrusion of cells (PubMed:12888489). RNAi-mediated knockdown significantly shortens lifespan (PubMed:35013237). Conditional knockdown in L1 larvae causes fully penetrant lethality with no viable larvae left by 38 hours (PubMed:36688410). Conditional knockdown causes abnormal molting/ecdysis, including extending the duration of molts (PubMed:36688410).

6239:CELE ZC455.7
gene id: 6239:CELE_ZC455.7
uniprot id: G3MU24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE M04G12.4
gene id: 6239:CELE_M04G12.4
uniprot id: A0A486WWJ9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: DNA-binding protein which binds to the promoters of let-60, lin-14 and lin-28, possibly to regulate genes involved in hypodermal and vulval development (PubMed:21979920). Together with miRNAs mir-84 and let-7 may direct terminal differentiation of the seam cells, exit from the molting cycle, and vulva formation (PubMed:21979920). Does not regulate the expression of mir-84 (PubMed:21979920). May promote hypodermal differentiation in association with swsn-9, a component of SWI/SNF chromatin remodeling complexes (PubMed:21979920).
messages: Expressed from embryogenesis to adulthood (PubMed:21979920). First expressed in comma stage embryos (PubMed:21979920). Highly expressed in L4 larvae and adults (PubMed:21979920).
messages: Expressed in hypodermal seam cells, the somatic gonad and vulval precursor cells, body wall muscle and head neurons.
messages: May interact with swsn-9; the interaction promotes hypodermal differentiation.
messages: Nucleus

6239:CELE C33D12.2
gene id: 6239:CELE_C33D12.2
uniprot id: A0A131MCZ8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the ACDP family.
messages: Highly expressed in the intestine and in neurons, but it is also expressed in a variety of tissues including the pharynx, hypodermis, rectum and in muscles.
messages: No visible phenotype. Double knockout with cnnm-1 results in increased levels of intestinal Mg(2+) and reduced levels in other tissues. This Mg(2+) deficiency in tissues leads to a reduced lifespan, 100% sterility, and smaller animals that exhibit a developmental delay with defective gonad development and which therefore do not produce oocytes or form vulva. In addition, the gonad development defect in the cnnm-1 and cnnm-3 double knockout is rescued when the AMPK alpha subunit aak-2 is also knocked out. Double knockout with cnnm-2 results in 22% sterility. Quintuple knockout with cnnm-1, cnnm-2, cnnm-4 and cnnm-5 results in a reduced lifespan and 100% sterility.
messages: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.

6239:CELE Y73B6BL.289
gene id: 6239:CELE_Y73B6BL.289
uniprot id: U4PRZ3
names: Similarity
messages: Belongs to the BLOC1S2 family.

6239:CELE Y69A2AR.5
gene id: 6239:CELE_Y69A2AR.5
uniprot id: Q95XG9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development.
messages: Expressed exclusively in the intestine.
messages: Expression detected initially in the gastrula-stage embryos and continuing throughout all developmental stages to adulthood.
messages: Homodimer.
messages: Mutant worms (tm3673) exhibit decreased egg-laying capacity with smaller brood size and lower hatching rates at 25 degrees Celsius. Worms do not show any change in physical appearance.
messages: Peroxisome

6239:CELE F54G8.4
gene id: 6239:CELE_F54G8.4
uniprot id: Q03601
names: Disruption Phenotype
names: Subunit
messages: Double knockout with par-2 mutant (it5ts) partially suppresses the lethality phenotype of the par-2 mutant (it5ts) at 25 degrees Celsius.
messages: Interacts with ubc-13.

6239:CELE Y105C5B.2
gene id: 6239:CELE_Y105C5B.2
uniprot id: A0A078BQP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in AQR, PQR and URX sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE ZC404.13
gene id: 6239:CELE_ZC404.13
uniprot id: Q95PY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C01G10.8
gene id: 6239:CELE_C01G10.8
uniprot id: Q93168
names: Similarity
messages: Belongs to the AHA1 family.

6239:CELE ZK418.7
gene id: 6239:CELE_ZK418.7
uniprot id: Q23485
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K01A12.3
gene id: 6239:CELE_K01A12.3
uniprot id: Q10042
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

6239:CELE K05F1.3
gene id: 6239:CELE_K05F1.3
uniprot id: Q21243
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE K08F11.3
gene id: 6239:CELE_K08F11.3
uniprot id: Q94261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (PubMed:17403899). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF (PubMed:17403899). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3 (PubMed:17403899).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif-3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts directly with csn-1 and csn-4.
messages: Cytoplasm

6239:CELE C44H4.5
gene id: 6239:CELE_C44H4.5
uniprot id: G5EEM6
names: Caution
names: Disruption Phenotype
names: Function
names: Subunit
messages: Interacts with mom-4; the interaction enhances mom-4 kinase activity.
messages: Involved in the Wnt signaling pathway by regulating mom-4 kinase activity.
messages: Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.
messages: RNAi-mediated knockdown causes no obvious phenotype. Results in a 3-fold increase in the number of animals lacking a gut in a mom-4 (or11) mutant background.

6239:CELE Y71H2AM.24
gene id: 6239:CELE_Y71H2AM.24
uniprot id: Q3V5J2
names: Similarity
messages: Belongs to the TBCC family.

6239:CELE F44C8.2
gene id: 6239:CELE_F44C8.2
uniprot id: O16361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y56A3A.11
gene id: 6239:CELE_Y56A3A.11
uniprot id: Q9U218
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

6239:CELE R06F6.1
gene id: 6239:CELE_R06F6.1
uniprot id: Q09599
names: Function
names: PTM
names: Similarity
messages: Belongs to the SLBP family.
messages: Involved in histone pre-mRNA 3' processing (PubMed:11782412). Required for chromosome condensation, progression of cell death and morphogenesis (PubMed:11782412).
messages: Ubiquitinated by the CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex, leading to its degradation.

6239:CELE ZK673.2
gene id: 6239:CELE_ZK673.2
uniprot id: Q09629
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Cytoplasm
messages: Monomer.

6239:CELE Y22D7AR.5
gene id: 6239:CELE_Y22D7AR.5
uniprot id: G5EF00
names: Similarity
messages: Belongs to the globin family.

6239:CELE T05C3.5
gene id: 6239:CELE_T05C3.5
uniprot id: O16303
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H35N03.1
gene id: 6239:CELE_H35N03.1
uniprot id: G5ECJ0
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
messages: Cell membrane
messages: Defective in enteric muscle contraction resulting in abnormal defecation cycles and moderate to severe constipation.
messages: Expressed in the intestinal and anal depressor muscles but not in the sphincter muscle. Also detected in the RID and SABD ring interneurons, the ADE sensory neuron and the PDA motor neuron.
messages: GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+) (PubMed:14555952). Has negligible divalent cation permeability (PubMed:14555952). Does not act as a chloride channel (PubMed:14555952). Mediates enteric muscle contractions required for defecation (PubMed:14555952, PubMed:2323555, PubMed:16236771). Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells (PubMed:25849533).
messages: Interacts with tax-6; tax-6 may be involved in negative regulation of exp-1 activity. May self-associate to form homodimer.
messages: Resistant to channel blocking activity of mecamylamine and bicuculline.
messages: Synapse

6239:CELE W09C3.6
gene id: 6239:CELE_W09C3.6
uniprot id: O02658
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family.
messages: Chromosome
messages: Cytoplasm
messages: Due to the high similarity between gsp-3 and gsp-4, the antibody used to study expression does not distinguish between the two proteins.
messages: Expressed at all stages of spermatocyte meiosis.
messages: Expressed in male germline including spermatocytes, spermatids and spermatozoa.
messages: No obvious phenotype (PubMed:22042574). Simultaneous RNAi-mediated knockdown of gsp-3 and gsp-4 results in male sterility due to chromosome segregation defects during sperm meiosis (PubMed:16943775). gsp-3 and gsp-4 double mutant hermaphrodites have egg laying defects and no viable progeny. gsp-3, gsp-4 and him-8 triple mutants have incomplete separation of sister chromatids during the second meiotic segregation. Mislocalization of MSP in activated sperm. In addition, have partial reduction in mpk-1 phosphorylation and air-2 association with bivalent chromosomes in the most proximal oocyte in response to MSP (PubMed:22042574).
messages: Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis (PubMed:16943775, PubMed:22042574). In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium (PubMed:22042574).
messages: pseudopodium

6239:CELE W08D2.7
gene id: 6239:CELE_W08D2.7
uniprot id: Q23223
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Nucleus

6239:CELE F55G1.13
gene id: 6239:CELE_F55G1.13
uniprot id: Q20852
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE ZK863.7
gene id: 6239:CELE_ZK863.7
uniprot id: Q10667
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed throughout the germline.
messages: Hermaphrodites are sterile and produce no oocytes due to the failure of the germ line to transition from spermatogenesis to oogenesis during oocyte development.
messages: RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development.

6239:CELE F35E8.10
gene id: 6239:CELE_F35E8.10
uniprot id: G5EEU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F13B12.4
gene id: 6239:CELE_F13B12.4
uniprot id: Q19374
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. Highly divergent.

6239:CELE W10C6.1
gene id: 6239:CELE_W10C6.1
uniprot id: O18191
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC1 family.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076, PubMed:11861581). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
messages: RNAi-mediated knockdown results in defective metaphase to anaphase transition (Mat phenotype) and embryos that arrest at the one-cell stage.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE C56C10.9
gene id: 6239:CELE_C56C10.9
uniprot id: Q18887
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

6239:CELE F59C6.5
gene id: 6239:CELE_F59C6.5
uniprot id: Q93831
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

6239:CELE Y105E8A.9
gene id: 6239:CELE_Y105E8A.9
uniprot id: Q8WQB3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

6239:CELE H39E23.1
gene id: 6239:CELE_H39E23.1
uniprot id: Q9TW45
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.
messages: Maternally expressed.
messages: Phosphorylated at Thr-325 probably by par-4.
messages: Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).
messages: cell cortex

6239:CELE VW02B12L.1
gene id: 6239:CELE_VW02B12L.1
uniprot id: G5EGP4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in P2 cell of 4-cell stage embryo (at protein level) (PubMed:11441002). At the comma stage, expressed in cells in the lateral sides (at protein level) (PubMed:11441002). Specifically expressed in intestine from the 2-fold embryonic stage onwards including in the larval and adult stages (at protein level) (PubMed:11441002, PubMed:19741196).
messages: RNAi-mediated knockdown causes larval lethality at the L1 stage (PubMed:11441002). RNAi-mediated knockdown at the L1 larval stage causes reduced growth rate (PubMed:19741196). The progeny of the few that reach adulthood is arrested at the L1 larval stage (PubMed:19741196). Rhythmic defecation behavior is altered; the defecation cycle period is extended and animals have a slight arrhythmia (PubMed:19741196). In the intestinal epithelium, pH oscillates once per cycle as in the wild-type, but the oscillations are diminished in amplitude and cells are relatively acidic (PubMed:19741196). Also, luminal pH oscillations are reduced (PubMed:19741196). RNAi-mediated knockdown at the L2 larval stage causes a reduction of whole body fat mass in young adults (PubMed:19741196). In some animals, the lumen appears swollen, with a reduction of the cytoplasmic contents of intestinal cells (PubMed:19741196). Defect in nutrient absorption (PubMed:19741196).
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:19741196). In the intestine, required for the rhythmic defecation behavior by promoting acidification in the gut lumen following defecation (PubMed:19741196). Also, luminal acidification is required for nutrient uptake (PubMed:19741196).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunit C vha-11 (PubMed:11441002).

6239:CELE H28O16.1
gene id: 6239:CELE_H28O16.1
uniprot id: Q9XXK1
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and is required for the assimilation of enterobactin-bound iron from non-pathogenic bacteria. Promotes mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown of the protein leads to impaired growth and development. In addition, it impairs the assimilation of enterobactin-bound iron.
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps them scavenge iron ions from the environment. Enterobactin produced by non-pathogenic E.coli strains facilitates iron assimilation in C.elegans (PubMed:30146159). Other siderophores, such as ferrichrome and pyoverdine that is produced by pathogenic bacteria, do not facilitate intestinal iron absorption in C.elegans (PubMed:30146159).
messages: Ubiquitous (at protein level).

6239:CELE Y11D7A.11
gene id: 6239:CELE_Y11D7A.11
uniprot id: Q9XWR2
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C27H5.1
gene id: 6239:CELE_C27H5.1
uniprot id: Q18268
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

6239:CELE T10B9.10
gene id: 6239:CELE_T10B9.10
uniprot id: Q27519
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE F26F12.7
gene id: 6239:CELE_F26F12.7
uniprot id: G5EBZ4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the MEC (MEP-1-containing complex) complex that contains let-418, mep-1 and hda-1 (PubMed:21060680). Component of a NURD complex that contains let-418, hda-1, lin-40 and lin-53 (PubMed:21060680). Interacts with lin-1 (PubMed:17466968). Interacts with pie-1 (PubMed:12507426). Interacts with akir-1 (PubMed:30036395).
messages: Expressed in all interphase nuclei throughout development.
messages: Expressed in embryos and larva.
messages: Larval arrest, protruding vulva, sterile progeny.
messages: Nucleus
messages: Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate (PubMed:11076750, PubMed:21060680). This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1 (PubMed:17466968). Contributes to negative regulation of lag-2 which is expressed in the gut during larval development (PubMed:21060680). Has a broad role in development (PubMed:21060680). In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection (PubMed:30036395).

6239:CELE F59F5.1
gene id: 6239:CELE_F59F5.1
uniprot id: G5ECR3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T27A3.1
gene id: 6239:CELE_T27A3.1
uniprot id: Q86NB6
uniprot id: Q86NB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Mitochondrion

6239:CELE F52B11.1
gene id: 6239:CELE_F52B11.1
uniprot id: Q9XUE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with wdr-5.1, ash-2 and dpy-30 (PubMed:31602465). Also interacts with the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Interacts with sin-3, hda-1 and mrg-1 (PubMed:31602465).
messages: Nucleus
messages: Transcriptional activator that exhibits a unique DNA binding specificity for CpG motifs; enriched at promoters containing the trimethylation mark on histone H3 'Lys-4' (H3K4me3) (PubMed:24653213). Forms part of the SET2 complex and interacts with the SIN3S HDAC complex at promoters (PubMed:31602465). Required for H3K4 trimethylation and plays a repressive role in the expression of heat shock and salt-inducible genes (PubMed:30941832). Required for fertility, in cooperation with class I histone deacetylases (HDACs) (PubMed:24653213, PubMed:30941832, PubMed:31602465).

6239:CELE K01A2.7
gene id: 6239:CELE_K01A2.7
uniprot id: Q9TZ57
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y71H2AM.9
gene id: 6239:CELE_Y71H2AM.9
uniprot id: Q3V5J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

6239:CELE H04J21.2
gene id: 6239:CELE_H04J21.2
uniprot id: O44811
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE D2013.8
gene id: 6239:CELE_D2013.8
uniprot id: Q18968
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

6239:CELE F53H8.2
gene id: 6239:CELE_F53H8.2
uniprot id: P51485
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR) (PubMed:15878875). May play a role in clathrin-mediated GPCR endocytosis (PubMed:15878875). Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition (PubMed:20207731). Involved in egg-laying (PubMed:15878875).
messages: Belongs to the arrestin family.
messages: Component of a complex composed of arr-1, daf-18 and mpz-1 (PubMed:20207731). Within the complex, interacts (via C-terminus) with mpz-1 (via PDZ domain) and phosphatase daf-18 (PubMed:20207731). May interact (via C-terminus) with clathrin chc-1 and beta-2 adaptin (AP2) apb-1 (PubMed:15878875).
messages: Expressed in head neurons, nerve ring and ventral nerve cord (at protein level) (PubMed:15878875). Expressed in the nervous system including the nerve ring and the ventral and dorsal nerve cords (PubMed:15878875, PubMed:15157420). Highly expressed in amphid chemosensory neurons AWA, AWB, AWC, ADL and ASH, and in hermaphrodite specific neuron HSN (PubMed:15878875, PubMed:15157420). Also expressed in the intestine (PubMed:15157420).
messages: No effect on the response to the aversive chemical stimulus octanol or to volatile attractants (PubMed:15157420). Behavioral adaptation to prolonged exposure to isoamyl alcohol or benzaldehyde is impaired (PubMed:15878875). Recovery of chemotaxis from odorant-induced adaptation is impaired (PubMed:15878875). Moderate reduction in chemotaxis towards volatile attractant diacetyl but not towards isoamyl alcohol and benzaldehyde (PubMed:15878875). Slight defect in egg-laying (PubMed:15878875). Increased lifespan and nuclear localization of daf-16 (PubMed:20207731). Reduced lifespan in a daf-16 (mu86) mutant background or in a mpz-1 RNAi-mediated knockdown background (PubMed:20207731).
messages: Perikaryon
messages: The C-terminus (aa 369-435) is required for the recovery of chemotaxis from odorant-induced adaptation but is dispensable for behavioral adaptation to chemoattractant isoamyl alcohol.
messages: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates the interaction with the AP-2 complex subunit apb-1.
messages: dendrite

6239:CELE R05G6.7
gene id: 6239:CELE_R05G6.7
uniprot id: Q21752
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of membrane-spanning sided beta-sheets.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules (By similarity). Plays a role in maintaining mitochondrial morphology (PubMed:25190516).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown results in a hyper-connected mitochondrial network in body wall muscle cells.

6239:CELE C17B7.5
gene id: 6239:CELE_C17B7.5
uniprot id: O45155
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE C14C10.1
gene id: 6239:CELE_C14C10.1
uniprot id: Q17970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y116A8C.16
gene id: 6239:CELE_Y116A8C.16
uniprot id: H2KML1
uniprot id: Q9U2V5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C01B10.6
gene id: 6239:CELE_C01B10.6
uniprot id: H2KYC9
uniprot id: Q8MQF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C28H8.1
gene id: 6239:CELE_C28H8.1
uniprot id: Q09242
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals are sterile producing no oocytes, display a protruding vulva phenotype past the young adult stage of development, and have disrupted or no alae formation. Fewer seam cells in larval stages post the L1 larval stage of development and impaired seam cell differentiation with large and irregularly shaped nuclei in seam cell-derived hyp7 cells. Defective gonadal growth and proliferation whereby gonads are thin and shortened probably due to decreased mitosis, and abnormal germ cell nuclei which are irregularly shaped and enlargened. Mis-localization of the beta-catenin homolog wrm-1 in the daughter cells of seam cells following cell division with expression equal to or stronger in the anterior daughter cells as opposed to the posterior daughter cells in 50% of mutants. Aberrant asymmetric localization of the wnt signaling component pop-1 in the nuclei of Z1 and Z4 somatic gonadal precursor cells. Increased expression of anti-apoptotic factor ced-9. RNAi-mediated knockdown results in egg-laying defective and burst vulva phenotypes.
messages: Belongs to the BCL7 family.
messages: Expressed in the hypodermis from embryogenesis to adulthood.
messages: Nucleus
messages: Required for the terminal differentiation of seam cells, and the differentiation of distal tip cells important for normal somatic gonad and germ cell development. Plays a role in the Wnt signaling pathway, regulating the expression of beta-catenin homologs wrm-1, bar-1 and sys-1, and the localization of wrm-1 and the wnt signaling pathway component pop-1 during asymmetric cell division of seam cells and the Z-cell lineage of the somatic gonad, respectively. May have a pro-apoptotic role, possibly linked to the negative regulation of expression of anti-apoptotic factor ced-9.
messages: Ubiquitous.

6239:CELE K02H8.1
gene id: 6239:CELE_K02H8.1
uniprot id: Q94250
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the muscleblind family.
messages: Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'.
messages: Expressed in neurons around the pharynx.
messages: Nucleus
messages: Reduced lifespan.

6239:CELE C02C6.1
gene id: 6239:CELE_C02C6.1
uniprot id: P39055
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Cytoplasm
messages: Expressed in motor neurons in the head and in ventral nerve cord and, to a lesser extent, in sensory neurons in the nerve ring and the tail and interneurons. Expressed in pharyngeal-intestinal valve, intestinal-rectal valve and in intestinal cells.
messages: May be a component of a complex composed of rab-5 (in GDP-bound form), dyn-1 and vps-34 (PubMed:18425118). Interacts with tax-6 (PubMed:20803083).
messages: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis (PubMed:20803083). Involved in apoptotic cell phagocytosis (PubMed:21490059). Required for recruitment of phosphatidylinositol 3-kinase piki-1 to phagosomes (PubMed:22272187). May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes (PubMed:18425118). Required for embryonic and larval development (PubMed:9294229, PubMed:21490059, PubMed:20803083).
messages: RNAi-mediated knockdown causes abnormal accumulation of apoptotic cell corpses in early phagosomes in gonads.
messages: cytoskeleton
messages: phagosome membrane

6239:CELE Y105E8A.6
gene id: 6239:CELE_Y105E8A.6
uniprot id: Q9NEZ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during embryogenesis, in larvae and in adult animals.
messages: Expressed in the body wall muscles, vulval muscles and the anal muscles (PubMed:15210732, PubMed:20385102). Expressed in the muscle arms of the head muscle cells that form neuromuscular junctions and in the anal depressor muscle (PubMed:15210732).
messages: M line
messages: Nucleus
messages: RNAi-mediated knockdown leads to disorganized actin-containing I band filaments, disorganized dense bodies in the muscles and reduced motility.
messages: Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732, PubMed:20385102). Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting (PubMed:20385102). Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion (PubMed:15210732).
messages: Ubiquitinated. Ubiquitination by rnf-5 leads to dissociation from muscle dense bodies during molting and is required for ecdysis.
messages: focal adhesion

6239:CELE Y54E10BR.5
gene id: 6239:CELE_Y54E10BR.5
uniprot id: Q9N3D0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE C45G7.3
gene id: 6239:CELE_C45G7.3
uniprot id: O76357
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
messages: Expressed in pharynx grinder muscle pm7, isthmus marginal cell mc2 and pharyngeal muscle cell pm5, intestinal cells and at lower levels in coelomocytes and epidermis (PubMed:27525822). Expressed at low levels in intestine (PubMed:20617181).
messages: Expression levels are low throughout larval stages and then increase in adults. Intestinal expression starts at the L1 larval stage, declines at the L2 larval stage and increases again in L4 larvae and adults. Highly expressed in the intestinal lumen of dauer larvae and, old and no longer self-fertile adults.
messages: Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria.
messages: Induced in the intestine by Gram-positive bacteria M.nematophilum CBX102 and UV336 and M.luteus DMS20030 infection but not by Gram-negative bacterium P.aeruginosa PAO1 infection (PubMed:27525822). Induced in the intestine, pharynx and vulva by Gram-positive bacterium S.aureus infection (PubMed:20617181). Induced by Gram-positive bacterium B.subtilis (PubMed:20617181). Induced by starvation (PubMed:27525822).
messages: Late endosome lumen
messages: Lysosome lumen
messages: Recycling endosome lumen
messages: Secreted
messages: Slight reduction in brood size. 24 percent reduction in lifespan which is further reduced upon M.nematophilum CBX102 bacterial infection. Impaired food digestion characterized by the accumulation of unlysed E.coli in the intestine. Accumulation of unlysed bacteria is stronger upon M.nematophilum CBX102 infection.

6239:CELE F11G11.3
gene id: 6239:CELE_F11G11.3
uniprot id: P91252
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE C27H6.9
gene id: 6239:CELE_C27H6.9
uniprot id: A9QY30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
messages: Mitochondrion

6239:CELE C05G5.5
gene id: 6239:CELE_C05G5.5
uniprot id: Q17678
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease.

6239:CELE K02A2.2
gene id: 6239:CELE_K02A2.2
uniprot id: Q09572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F39C12.4
gene id: 6239:CELE_F39C12.4
uniprot id: Q4R128
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the vasopressin/oxytocin family.
messages: Detected in thermosensory AFD neurons, neurosecretory NSM cells, AVK interneurons, pharyngeal neuron M5, and the mechanosensory DVA neuron (PubMed:23112336, PubMed:23112335). Detected in male-specific CP motor neurons (PubMed:23112335).
messages: Ligand for the G-protein coupled receptor ntr-1 (PubMed:23112336, PubMed:23112335). Plays a role in gustatory associative learning (PubMed:23112336). Also plays a role in male mating behavior (PubMed:23112335).
messages: Secreted
messages: Viable and fertile (PubMed:23112336). Gustatory associative learning in response to salt cues is disrupted (PubMed:23112336). Males have reduced reproductive success, due to a range of aberrant mating behaviors (PubMed:23112335).

6239:CELE ZK1128.2
gene id: 6239:CELE_ZK1128.2
uniprot id: Q09357
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Expressed in the intestine, vulva, and cells of the somatic gonad including distal tip cells, gonadal sheath cells and spermatheca.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289). Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194). Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194). Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).
messages: Self-associates (PubMed:19752194). Interacts with dlc-1; the interaction is direct, and is required for nuclear localization of mett-10 (PubMed:19752194).

6239:CELE C07A12.5
gene id: 6239:CELE_C07A12.5
uniprot id: Q17768
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in eggs, L2 stage and in adult. Expressed at lower level in L1, L3 and L4 stages.
messages: Loss of function results in a suppression of sel-12 mutant phenotypes, possibly by up-regulating hop-1 expression.
messages: Nucleus
messages: Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1.

6239:CELE C42C1.11
gene id: 6239:CELE_C42C1.11
uniprot id: G5EFT4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Despite its similarity to leukotriene hydrolases, AP-1 does not have leukotriene hydrolase activity. One of the mammalian leukotriene binding sites, 'Tyr-378', is replaced by a Phe residue in AP-1.

6239:CELE ZK858.5
gene id: 6239:CELE_ZK858.5
uniprot id: Q94421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

6239:CELE M03F4.2
gene id: 6239:CELE_M03F4.2
uniprot id: P10986
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.
messages: cytoskeleton

6239:CELE F53C11.9
gene id: 6239:CELE_F53C11.9
uniprot id: Q0G820
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C02H7.3
gene id: 6239:CELE_C02H7.3
uniprot id: O02626
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in nearly all neurons.
messages: Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release (PubMed:9136770, PubMed:10970871). Is also a regulator of the cab-1 synaptic transmission pathway (PubMed:10970871). Probably by converting rab-3 to its GTP-bound active form, plays a role in the recruitment of endophilin unc-57 to synaptic vesicles (PubMed:21029864). Probably by activating rab-3 and thus regulating the trafficking of dense-core vesicles, plays a role in AVG neuron-mediated formation of the right axon tract of the ventral nerve cord (PubMed:27116976). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:18852466). Probably by regulating DMP, required for fatty acid uptake by intestinal cells (PubMed:25849533).
messages: Interacts with cab-1.
messages: Worms exhibit pleiotropic behavioral defects that are suggestive of reduced synaptic transmission (PubMed:9136770). RNAi-mediated knockdown in the intestine causes a mild defect in the expulsion step of the defecation cycle (PubMed:18852466).

6239:CELE ZK678.6
gene id: 6239:CELE_ZK678.6
uniprot id: O62517
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C39E9.10
gene id: 6239:CELE_C39E9.10
uniprot id: Q18545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE W10D9.4
gene id: 6239:CELE_W10D9.4
uniprot id: O17286
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y and nfya-2-NF-Y) complexes which specifically recognize a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the NF-Y complexes, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492, PubMed:25873636). May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (PubMed:25873636). In association with the components in the nfya-1-NF-Y complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head (PubMed:17574230). May regulate spatial egl-5 expression in association with the mes-2-mes-3-mes-6 complex (PubMed:17574230).
messages: Cytoplasm
messages: Expressed in cells of the developing embryo (PubMed:15704008, PubMed:17574230). At the larval stages, weakly expressed in neurons and pharyngeal secretory cells (PubMed:15704008, PubMed:17574230). At larval stages also expressed in the developing hermaphrodite vulva and male tail (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008).
messages: Expressed in certain parts of the gonads with high expression in fertilized oocytes in the uterus and mature oocytes from the distal to the proximal arm of the gonad, but weak expression in the syncytial ovaries and immature oocytes at the beginning of the proximal arm of the gonad (PubMed:15704008). Expressed in secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008). Not expressed in the intestine, the hypodermis or body wall muscle surrounding the pseudocoelomic space (PubMed:15704008).
messages: Forms two NF-Y heterotrimeric transcription factor complexes: the nfya-1-NF-Y complex is composed of nfya-1, nfyb-1 and nfyc-1, and the nfya-2-NF-Y complex is composed of nfya-2, nfyb-1 and nfyc-1 (PubMed:17574230). Interacts with nfyc-1; the interaction is direct and is required for the interaction with either nfya-1 or nfya-2, and subsequent binding of the complex to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230).
messages: Nucleus
messages: Perikaryon
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). RNAi-mediated knockdown results in ectopic expression of tbx-2 in the gut and seam cells of L4 stage larvae and adults (PubMed:23933492). RNAi-mediated knockdown enhances the larval lethality phenotype of the tbx-2 bx59 mutant (PubMed:23933492).

6239:CELE F31D5.1
gene id: 6239:CELE_F31D5.1
uniprot id: Q19933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C15A7.1
gene id: 6239:CELE_C15A7.1
uniprot id: Q17999
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE W06H8.1
gene id: 6239:CELE_W06H8.1
uniprot id: G5EEU7
uniprot id: G5EFP1
uniprot id: Q8WSP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

6239:CELE Y55D9A.1
gene id: 6239:CELE_Y55D9A.1
uniprot id: G5EET6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A short conserved N-terminal region is necessary for the function of this protein (PubMed:21943602, PubMed:26339988). Transient relocalization to microtubule minus ends after neuronal injury also requires this region (PubMed:26339988).
messages: Abnormally long and dense microtubules at the cellular cortex of early embryonic cells and growing microtubule plus ends reside at the cortex for up to five times longer. Causes excess centrosome separation and displacement towards the cellular cortex early in mitosis and subsequently a loss of anaphase spindle-pole oscillations and increased rates of spindle elongation. The centrosome separation phenotype is dependent on the motor protein dynein. Weakly delayed nuclear envelope breakdown (PubMed:21076413). Displays mild posterior lateral microtubule (PLM) axon overshooting in development and enhanced PLM regrowth following neuronal injury acting early in regrowth (PubMed:21943602). Axons display elevated numbers of growing microtubules in the steady (uninjured) state and display impenetrant developmental overgrowth in the absence of injury (PubMed:26339988).
messages: Cell membrane
messages: Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes (PubMed:21943602, PubMed:26339988). Limits microtubule growth near the cellular cortex of early embryonic cells (PubMed:21076413).
messages: Interacts (via short N-terminal region) with microtubule-associated proteins tac-1 and zyg-8.
messages: Isoform b: Enriched cortically both in the anterior portion of the one-cell zygote and at the blastomere boundary in two-cell embryos. Isoform c: Localizes to nonpolarized cellular cortex in oocytes and early one-cell zygotes and anterior cellular cortex in one-cell embryos subsequent to pseudocleavage. Present at the interface of the AB and P1 cells. Undetectable by the four-cell stage.
messages: cell cortex

6239:CELE C41C4.5
gene id: 6239:CELE_C41C4.5
uniprot id: H2FLG0
uniprot id: Q09274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Expressed in body wall muscle.
messages: Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development.
messages: Membrane

6239:CELE T08G5.10
gene id: 6239:CELE_T08G5.10
uniprot id: P17512
names: Domain
names: Function
names: Induction
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 6 family.
messages: By cadmium.
messages: This protein binds cations of several transition elements.

6239:CELE C39E6.6
gene id: 6239:CELE_C39E6.6
uniprot id: Q18534
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Expressed in neurons, including neurons in the head, the ventral nerve cord, and the preanal ganglion.
messages: G-protein coupled receptor for FARP(FMRFamide related peptide) neuropeptides (PubMed:12821653, PubMed:14555955). Activated by FARP neuropeptides flp-18 and flp-21 (PubMed:12821653, PubMed:14555955). Plays a role in modulating social and feeding behavior (PubMed:9741632). Required to modulate locomotion quiescence during the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity (PubMed:23764289, PubMed:27585848).
messages: It has been reported that many phenotypes associated with the Bristol N2 reference allele of npr-1 may reflect a neomorphic gain-of-function sensitivity of the receptor to flp-18 in addition to sensitivity to flp-21.
messages: Membrane

6239:CELE AC3.8
gene id: 6239:CELE_AC3.8
uniprot id: Q17404
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F36G3.3
gene id: 6239:CELE_F36G3.3
uniprot id: Q7YX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE F22B3.8
gene id: 6239:CELE_F22B3.8
uniprot id: Q19704
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE T13H5.4
gene id: 6239:CELE_T13H5.4
uniprot id: Q22469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

6239:CELE C31H1.5
gene id: 6239:CELE_C31H1.5
uniprot id: Q18339
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C49A1.3
gene id: 6239:CELE_C49A1.3
uniprot id: O17671
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F54H12.6
gene id: 6239:CELE_F54H12.6
uniprot id: P34460
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

6239:CELE T13F2.10
gene id: 6239:CELE_T13F2.10
uniprot id: Q9TVW5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE T03F1.12
gene id: 6239:CELE_T03F1.12
uniprot id: Q8I7G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Involved in protein trafficking.
messages: Membrane

6239:CELE B0218.1
gene id: 6239:CELE_B0218.1
uniprot id: Q17449
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the amidase family.
messages: Catalyzes the hydrolysis of endogenous amidated lipids like anandamide (AEA or N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine) and eicosapentaneoyl ethanolamide (EPEA or (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:21562563, PubMed:30911178). EPEA promotes dauer formation and may constitute a signal of high nutrient availability (PubMed:21562563). Breakdown of EPEA may promote lifespan extension when nutrient availability is high (PubMed:21562563). Facilitates axon regeneration after injury by degradating inhibitory compounds such as AEA (PubMed:23072806). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
messages: Expressed in the pharynx, some pharyngeal neurons, the posterior intestine and anal depressor muscles.
messages: Viable. Reduction (50 percent) in the frequency of motoneuron axon regeneration in young adults but not in L4 larvae.

6239:CELE C16D9.2
gene id: 6239:CELE_C16D9.2
uniprot id: Q8I7I5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Expressed between approximately 30-70 hours after egg lay at 15 degrees Celsius and between 15-35 hours after egg laying at 25 degrees Celsius relating to mid-L1 to mid-L3 stage of larval development.
messages: Membrane
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: Thought to have a role in developmental establishment of posterior morphology.
messages: Worms exhibit a larval lethal phenotype, survivors show a rolling phenotype in adults, a locomotive defect.

6239:CELE C15B12.8
gene id: 6239:CELE_C15B12.8
uniprot id: Q8WSW2
names: Similarity
messages: Belongs to the MSOX/MTOX family.

6239:CELE Y43F4B.3
gene id: 6239:CELE_Y43F4B.3
uniprot id: G5EEU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
messages: Chromosome
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate (PubMed:22939621, PubMed:28428426). Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina (PubMed:22939621). Required for small-RNA-induced H3K9 methylation (PubMed:26365259). Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9 (PubMed:27668659). Suppresses transcription from various repetitive genomic elements through methylation of H3K9; exposure to moderately raised temperature reduces methylation by set-25 leading to de-repression of transcription of repetitive elements lasting at least 3 subsequent generations, despite culture at lower temperatures (PubMed:28428426). May play a role in transgenerational transmission of environmental information (PubMed:28428426).
messages: Nucleus
messages: Nucleus lamina
messages: The SET domain is not required for localization to nuclear foci.

6239:CELE T28D9.9
gene id: 6239:CELE_T28D9.9
uniprot id: Q10026
names: Similarity
messages: Belongs to the lin-8 family.

6239:CELE Y59A8B.8
gene id: 6239:CELE_Y59A8B.8
uniprot id: Q9NEQ8
names: Similarity
messages: Belongs to the SNAP family.

6239:CELE C28H8.11
gene id: 6239:CELE_C28H8.11
uniprot id: Q09474
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Expressed in body wall muscle cells, hypodermis, PLM neurons and touch-receptor neurons.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine (PubMed:27995966). Catalyzes the oxidative cleavage of the indole moiety (PubMed:27995966). Involved in regulation of protein homeostasis, longevity and reproducive life span (PubMed:22927396, PubMed:27995966). Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (PubMed:22927396).
messages: Homotetramer. Dimer of dimers.
messages: RNAi-mediated knockdown of the protein increases longevity and causes a delayed and extended reproductive life span without increasing total progeny. Animals show increased levels of tryptophan, reduced sensitivity to proteotoxic aggregates of alpha-synuclein and reduced age-related decline of motility. A double knockdown of tdo-2 together with an enzyme downstream in the kynurenine pathway, kmo-1, flu-2, afmd-1 or haao-1, causes an increase in motility and tryptophan levels and suppresses the proteotoxicity similarly to knock-down of tdo-2 alone. RNAi-mediated knockdown in a tph-1 deletion background, which is necessary for synthesis of serotonin from trypotophan, shows increased motility, but variable suppression of proteotoxicity. RNAi-mediated knockdown in a mutant background for daf-16, which functions in the IIS pathway, shows suppression of proteotoxicity and only a small increase in median, but not mean life span. RNAi-mediated knockdown in a mutant background for hsf-1, which also functions in the IIS pathway, shows suppression of proteotoxicity and a small increase in life span. RNAi-mediated knockdown in a mutant background for hif-1, which functions in the hypoxia stress response pathway, shows an increase in median, but not mean life span that is lower than for the tdo-2 knockdown alone. RNAi-mediated knockdown in a mutant background for eat-2, which is used as a model for dietary restriction, shows suppression of proteotoxicity and an increase in life span.

6239:CELE F33D11.10
gene id: 6239:CELE_F33D11.10
uniprot id: O44781
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE C48E7.2
gene id: 6239:CELE_C48E7.2
uniprot id: Q8IG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

6239:CELE F07D10.1
gene id: 6239:CELE_F07D10.1
uniprot id: Q19162
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown results in a growth defect.
messages: There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.

6239:CELE Y47D3A.6
gene id: 6239:CELE_Y47D3A.6
uniprot id: P34708
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in intestine and gonads (at protein level).
messages: Interacts with the MX regulatory domain of tra-2.
messages: Isoform b is expressed abundantly in second larval (L2) stage. Isoform a is more abundant in embryos.
messages: Nucleus
messages: Only isoform a (Tra-1L), is thought to bind DNA. Zinc fingers 3, 4 and 5 are the most important for DNA binding; removal of finger 5 almost abolishes DNA binding and prevents the selection of binding sites.
messages: Plays a major role in controlling sexual phenotype (PubMed:1339311). Terminal global regulator in a well-characterized cascade of sex-determining genes (PubMed:8367286). Promotes female development (PubMed:11124807). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (PubMed:24682813). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (PubMed:18056428). Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis (PubMed:18550714). Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features (PubMed:28065609).

6239:CELE T05B4.7
gene id: 6239:CELE_T05B4.7
uniprot id: O16415
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R05D11.1
gene id: 6239:CELE_R05D11.1
uniprot id: Q21733
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Expressed in developing embryos from the pre-comma stage through to hatching (PubMed:20081192). Most highly expressed in larval stage L1 and gradually decreases into adulthood (PubMed:20081192). In larval stages, expressed throughout development in the ventral nerve cord, intestine, gonadal distal tip cells (DTCs) and subsets of head and tail neurons, most strongly in head neurons ASI and ADL (PubMed:20081192).
messages: Expressed in the excretory cell and gonadal distal tip cells (DTCs).
messages: Homodimer (Probable). Interacts with R-SMAD daf-14 and co-SMAD daf-3 (PubMed:20081192). Interacts with orphan nuclear receptor nhr-69 (PubMed:22359515).
messages: Nucleus
messages: Probably a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling (PubMed:10625546, PubMed:20081192). Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-14 (PubMed:10625546, PubMed:20081192). Plays a role in inhibiting mitosis and promoting a switch to meiosis in the germ line, perhaps by down-regulating lag-2 transcription in the gonadal distal tip cells (DTCs) (PubMed:20081192). In cooperation with orphan nuclear receptor nhr-69 modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of the insulin-like peptide daf-28 (PubMed:22359515).

6239:CELE C25A11.4
gene id: 6239:CELE_C25A11.4
uniprot id: A0A1C3NSL9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Controls adherens junction integrity (PubMed:11715019). Required for the correct rate and completion of elongation of the embryos (PubMed:11715019).
messages: Expressed by epithelial cells (PubMed:11715019). Expressed in sensory neuron dendritic tips (PubMed:27623382).
messages: Expression occurs in the embryonic hypodermis, pharynx and intestine, as well as in postembryonic epithelia, including the vulva, uterus, spermathecae, pharynx, intestine, hindgut, hypodermis and male tail.
messages: Interacts with dlj-1 (via L27 domain); the interaction regulates ajm-1 apical junction location.
messages: Mutant embryos enclose normally and initiate elongation without obvious morphological abnormalities, yet at a slower rate than the wild type. Elongation is consistently arrested at the 2-3-fold stage, accompanied by the formation of a large vacuole in the posterior region.
messages: The coiled-coil domain is sufficient to localize to apical junctions.
messages: adherens junction
messages: cilium

6239:CELE F36G9.16
gene id: 6239:CELE_F36G9.16
uniprot id: Q7YTM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK546.1
gene id: 6239:CELE_ZK546.1
uniprot id: Q23529
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hook family.
messages: Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus (PubMed:14697201). Required for dynein localization to the nuclear envelope (PubMed:14697201). Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair (PubMed:27956467).
messages: Does not contain a transmembrane domain.
messages: Expressed in the syncytial gonad, oocytes, and in all cells during the development of the early embryo.
messages: Homodimer (PubMed:14697201). Interacts with the dynein subunit dli-1 via its N-terminus (PubMed:14697201). May interact with microtubules (PubMed:14697201). Interacts with sut-2 (PubMed:19273536). Interacts (via C-terminus) with unc-84 (via C-terminus); the interaction is direct (PubMed:27956467).
messages: In contrast to isoform a and isoform d, isoform b and isoform c contain a potential transmembrane domain which may mediate insertion into the nuclear membrane.
messages: Induced by DNA-damage.
messages: Nucleus membrane
messages: RNAi-mediated knockdown results in a reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin.
messages: The large coiled coil domain is required for homodimerization.
messages: centrosome
messages: cytoskeleton

6239:CELE Y39E4A.3
gene id: 6239:CELE_Y39E4A.3
uniprot id: O45924
uniprot id: Q4A1S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCKDHA family.
messages: Mitochondrion matrix
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso) (PubMed:15340492).
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

6239:CELE K02D3.2
gene id: 6239:CELE_K02D3.2
uniprot id: Q21130
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

6239:CELE F22D6.10
gene id: 6239:CELE_F22D6.10
uniprot id: Q19725
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F28C12.1
gene id: 6239:CELE_F28C12.1
uniprot id: O17842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C40H1.1
gene id: 6239:CELE_C40H1.1
uniprot id: Q03571
names: Developmental Stage
names: Function
names: Subunit
messages: Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.
messages: Interacts with fbf-1.
messages: Present in the germline just prior to overt spermatogenesis; once sperm differentiation begins, it disappears.

6239:CELE Y48G8AL.8
gene id: 6239:CELE_Y48G8AL.8
uniprot id: Q9BL19
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

6239:CELE M01E5.4
gene id: 6239:CELE_M01E5.4
uniprot id: O45690
names: Similarity
messages: Belongs to the UPF0561 family.

6239:CELE F28B3.4
gene id: 6239:CELE_F28B3.4
uniprot id: A0A061AD00
uniprot id: A0A061AE78
names: Similarity
messages: Belongs to the DIP2 family.

6239:CELE F23B2.3
gene id: 6239:CELE_F23B2.3
uniprot id: O45402
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE Y69H2.14
gene id: 6239:CELE_Y69H2.14
uniprot id: Q8I4C0
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C52D10.13
gene id: 6239:CELE_C52D10.13
uniprot id: A3QM98
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T08H4.3
gene id: 6239:CELE_T08H4.3
uniprot id: Q22355
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Expressed in the A-neurons in the male-specific genital sensilla (simple sense organs) known as rays.
messages: Expressed in the embryo in sensory neurons with 6-fold symmetry, probably the inner labial neurons (PubMed:16584723). Expressed between comma and 3-fold stage, diminishing afterwards and absent in larval stages and adults (PubMed:16584723). Expressed in all dopaminergic neurons throughout postembryonic stages (PubMed:19287374). Expressed in a few cells in the pharynx at the 2-fold stage (PubMed:16584723).
messages: Nucleus
messages: RNAi-mediated knockdown abolishes expression of tyrosine monooxygenase cat-2 in neurons in the male-specific genital sensilla (simple sense organs) known as rays.
messages: Transcription factor (PubMed:16584723, PubMed:19287374, PubMed:23788625). Probably binds to DNA sequences containing the consensus motif 5'-CGGA[AT][AG]-3' (PubMed:19287374). Positively modulates expression of dopamine pathway genes, acting as a terminal selector for differentiation of dopaminergic neurons; may act in concert with homeobox proteins ceh-40, ceh-43 and ceh-20 (PubMed:19287374, PubMed:23788625, PubMed:22069471). Required for axon navigation in some interneurons, perhaps acting in the same pathways as basement membrane protein nid-1 and unc-6/netrin (PubMed:16584723). Plays a role in the differentiation of the ventral cord pioneer neuron AVG (PubMed:16584723). Required for morphogenesis of the pharynx (PubMed:16584723).
messages: neuron projection

6239:CELE F42C5.2
gene id: 6239:CELE_F42C5.2
uniprot id: Q20325
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C41D11.2
gene id: 6239:CELE_C41D11.2
uniprot id: O01974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE T23F11.3
gene id: 6239:CELE_T23F11.3
uniprot id: Q22695
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulation of presynaptic components in the dendrite of DA motor neurons (PubMed:20510931). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).
messages: Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1 (PubMed:17671168). In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport (PubMed:20510931). Regulates the polarized distribution of dense-core vesicles in DB motor neurons (PubMed:22699897). May regulate these processes in association with cdk-5 (PubMed:17671168, PubMed:20510931). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cytoplasm
messages: Expressed in all classes of neurons in the ventral cord.
messages: Heterodimer composed of a catalytic subunit cdk-5 and a regulatory subunit cdka-1. Interaction with cdka-1 is required for cdk-5 activation.
messages: axon
messages: dendrite

6239:CELE C01G5.6
gene id: 6239:CELE_C01G5.6
uniprot id: Q17569
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3.
messages: Belongs to the DDI1 family.
messages: Cytoplasm
messages: Expressed in most tissues.
messages: Increased sensitivity to low doses of bortezomib which causes proteasome dysfunction. Double knockout with proteasomal subunit pbs-5 or with rpt-5 knockdown results in failed expression of the proteasomal subunit rpt-3. Double knockout with pbs-5 also results in the occasional mis-localization of the transcription factor skn-1a within gut nuclei.
messages: Nucleus

6239:CELE K10D2.7
gene id: 6239:CELE_K10D2.7
uniprot id: Q09412
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

6239:CELE W05G11.3
gene id: 6239:CELE_W05G11.3
uniprot id: O44904
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y38H8A.3
gene id: 6239:CELE_Y38H8A.3
uniprot id: O62426
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE ZC581.1
gene id: 6239:CELE_ZC581.1
uniprot id: O01775
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Cytoplasm
messages: Expressed in hypodermal cells including in hyp7 syncytium but not in seam cells.
messages: Failure to shed the cuticle at the end of the first molt resulting in an arrest at the L1 to L2 transition stage. RNAi-mediated knockdown results in a less severe phenotype characterized by a failure to shed the cuticle only in the middle part of the body at the end of the first molt. In hyp7 syncytium, RNAi-mediated knockdown results in the apical membrane accumulation of lrp-1 and mislocalization of several components of the endocytic machinery.
messages: Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium.

6239:CELE F21A3.11
gene id: 6239:CELE_F21A3.11
uniprot id: H2FLJ4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

6239:CELE Y47H9C.7
gene id: 6239:CELE_Y47H9C.7
uniprot id: Q9XWD5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

6239:CELE C14A4.8
gene id: 6239:CELE_C14A4.8
uniprot id: Q17955
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE B0280.1
gene id: 6239:CELE_B0280.1
uniprot id: P41992
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.
messages: Heterodimer of an alpha and a beta subunit.

6239:CELE C36B1.7
gene id: 6239:CELE_C36B1.7
uniprot id: Q93341
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

6239:CELE K06B4.7
gene id: 6239:CELE_K06B4.7
uniprot id: O17931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F09E8.6
gene id: 6239:CELE_F09E8.6
uniprot id: Q19269
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal muscles and mc cells.
messages: Metalloprotease.
messages: Secreted

6239:CELE K03E6.5
gene id: 6239:CELE_K03E6.5
uniprot id: G5ED08
uniprot id: Q21190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Cell membrane
messages: gap junction

6239:CELE K09A9.3
gene id: 6239:CELE_K09A9.3
uniprot id: Q93871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE F11E6.5
gene id: 6239:CELE_F11E6.5
uniprot id: Q9XVQ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme responsible for the elongation of palmitate (hexadecanoate, 16:0), also involved in polyunsaturated fatty acid (PUFA) biosynthesis.
messages: Expressed in various tissues and parts of the body, including the ventral cord, pharyngeal muscles, uterus, and the tail, and most strongly in intestinal cells.
messages: Membrane
messages: Suppression of ELO-2 causes an accumulation of palmitate and an associated decrease in the PUFA fraction in triacylglycerides and phospholipid classes. This imbalance in the fatty acid composition results in multiple phenotypic defects such as slow growth, small body size, reproductive defects, and changes in rhythmic behavior (PubMed:12586704). Suppression of ELO-2 decreases growth rate and reduces brood size (PubMed:32961767).

6239:CELE PDB1.1
gene id: 6239:CELE_PDB1.1
uniprot id: H2KZN1
uniprot id: Q2L6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE E04F6.1
gene id: 6239:CELE_E04F6.1
uniprot id: Q19061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C05C10.4
gene id: 6239:CELE_C05C10.4
uniprot id: Q09451
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE H04J21.3
gene id: 6239:CELE_H04J21.3
uniprot id: O61208
uniprot id: Q8ITY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

6239:CELE F42G8.8
gene id: 6239:CELE_F42G8.8
uniprot id: O44507
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE W08E3.3
gene id: 6239:CELE_W08E3.3
uniprot id: P91917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Expressed in the nervous system, pharyngeal muscles and intestine (at protein level).
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Plays a role in regulating starvation-induced thermotaxis responses in AFD thermosensory neurons (PubMed:35675262).
messages: Monomer.

6239:CELE K06A4.1
gene id: 6239:CELE_K06A4.1
uniprot id: Q21252
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE F18F11.4
gene id: 6239:CELE_F18F11.4
uniprot id: P91263
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C56E10.1
gene id: 6239:CELE_C56E10.1
uniprot id: Q18895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C15F1.6
gene id: 6239:CELE_C15F1.6
uniprot id: Q9N5Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane

6239:CELE C14B9.1
gene id: 6239:CELE_C14B9.1
uniprot id: P34328
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F55C5.8
gene id: 6239:CELE_F55C5.8
uniprot id: Q20822
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), srpa-72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with srpa-72 (By similarity). Srpa-68/srpa-72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via C-terminus) with srpa-72 (via N-terminus) (By similarity).
messages: The N-terminus is required for RNA-binding.
messages: nucleolus

6239:CELE C23H3.1
gene id: 6239:CELE_C23H3.1
uniprot id: P91082
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: During the L3 larval stage, transiently expressed in the anchor cell, in rectal epithelial cells D, VL, and VR, in B and in Y, and in several neuronal cells (PubMed:11784109). During the L4 larval stage, expressed near the vulva and the uterus, with expression lining the lumen of the uterus and portions of the vulval lumen including the vulval toroid cells vulB and vulE (PubMed:11784109). During the L4 larval stage, not expressed in the vulval toroid vulF (PubMed:11784109).
messages: Highly expressed in the cells of the spermatheca, the mouth, and the lining of the pharynx, the rectum, and the excretory canal (PubMed:11784109). Also expressed in the pharyngeal intestinal junction cell (PubMed:11784109).
messages: Putative acyltransferase (Probable). Plays a role in the morphogenesis of a vulval toroid cell, vulF, which is located where the vulva and the uterus connect (PubMed:11784109, PubMed:17560977). Not required for specifying vulval cell fate (PubMed:17560977).

6239:CELE ZC416.6
gene id: 6239:CELE_ZC416.6
uniprot id: O44183
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE T16G12.1
gene id: 6239:CELE_T16G12.1
uniprot id: Q22531
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Putative aminopeptidase which plays a role in oocyte maturation.
messages: RNAi-mediated knockdown causes an expansion of the pachytene zone in the gonads of 31 percent of animals and a delay in oocyte nucleolus disassembly. Brood size is normal and embryos are viable.

6239:CELE F57B10.1
gene id: 6239:CELE_F57B10.1
uniprot id: O44743
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Expressed in the gonadal distal tip cells (DTC) during larval stages L2, L3 and L4.
messages: Nucleus
messages: Probable transcription factor, required during migration of the gonadal distal tip cells (DTC) (PubMed:24811939). Probably regulates cell adhesion of DTCs via modulation of expression of genes involved in integrin-mediated adhesion, including tln-1, src-1, and integrin pat-2 (PubMed:24811939). Modulates expression of genes involved in protein trafficking during embryogenesis, including emo-1, sec-61, calu-1, sec-24.1, enpl-1, sar-1 and tfg-1 (PubMed:27510972).
messages: RNAi-mediated knockdown targeted to the gonadal distal tip cells (DTC) causes DTC migration defects (PubMed:24811939). Significant reduction in expression of src-1 and tln-1 in DTCs (PubMed:24811939). Causes slow growth after hatching (PubMed:27510972).

6239:CELE T24D1.4
gene id: 6239:CELE_T24D1.4
uniprot id: O02332
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE K06C4.4
gene id: 6239:CELE_K06C4.4
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y48C3A.10
gene id: 6239:CELE_Y48C3A.10
uniprot id: Q9NAG2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

6239:CELE C06B8.7
gene id: 6239:CELE_C06B8.7
uniprot id: O17575
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W04E12.7
gene id: 6239:CELE_W04E12.7
uniprot id: G5EE34
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE C32E8.10
gene id: 6239:CELE_C32E8.10
uniprot id: Q9XZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.
messages: Belongs to the PICALM/SNAP91 family.
messages: Binds clathrin and phosphatidylinositol 4,5-bisphosphate.
messages: Golgi apparatus
messages: High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies.
messages: clathrin-coated pit
messages: clathrin-coated vesicle

6239:CELE F08A8.1
gene id: 6239:CELE_F08A8.1
uniprot id: O62140
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by ATP (PubMed:27551084). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (PubMed:27551084). ATP binding likely occurs during acox-1.1 folding and/or dimer formation (PubMed:27551084).
messages: Belongs to the acyl-CoA oxidase family.
messages: Expressed in hypodermis and intestine.
messages: Homodimer (Probable). Forms a heterodimer with acox-1.2 (PubMed:25775534). Forms a heterodimer with acox-1.3; the interaction may be important for the stability of acox-1.3 (PubMed:25775534).
messages: Induced by high temperatures (25 degrees Celsius).
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains (PubMed:25775534, PubMed:29537254, PubMed:27551084). Specifically, catalyzes the desaturation of fatty acids heptanoyl-CoA (C7), nonanoyl-CoA (C9), dodecanoyl-CoA (C12) and to a lesser extent pentanoyl-CoA (C5) and hexadecanoyl-CoA (C16), and hydroxylated fatty acid hydroxynonanoyl-CoA (PubMed:25775534, PubMed:29537254, PubMed:27551084). Also, catalyzes the desaturation fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:20610393, PubMed:25775534, PubMed:29537254, PubMed:29863473, PubMed:27551084). Specifically, shortens ascaroside with 5-carbon omega side chain (asc-omega-C5), 7-carbon side chain (asc-C7), 9-carbon side chain (asc-C9), 11-carbon side chain (asc-C11), 13-carbon side chain (asc-C13), 15-carbon side chain (asc-C15) and to a lesser extent ascarosides with 7-omega-carbon side chain (asc-omega-C7) (PubMed:25775534, PubMed:29537254, PubMed:27551084). Also shortens indol-3-carbonyl(IC)-ascarosides with 7-carbon side chain (IC-asc-C7) and to a lesser extent (IC)-ascarosides with 9-carbon side chain (IC-asc-C9) (PubMed:29863473). May associate and regulate the folding and/or the catalytic activity of other acyl-coenzyme A oxidases including acox-1.2, acox-1.3, acox-1.4 and acox-3 modulating the type of ascarosides produced (PubMed:25775534, PubMed:29537254, PubMed:29863473). In association with acox-1.3, catalyzes the desaturation of asc-C7-CoA but not of fatty acids or hydroxylated fatty acids (PubMed:25775534). Involved in the biosynthesis of asc-C6-MK (daumone 2) and asc-delta-C9 (daumone 3) but not asc-C7 (daumone 1); daumones are pheromones produced during unfavourable growth conditions which promote entry into the dauer stage (PubMed:20610393).
messages: Peroxisome
messages: RNAi-mediated knockdown abolishes production of dauer pheromone daumone 2, severely reduces production of daumone 3 and increases production of daumone 1.

6239:CELE Y51H1A.5
gene id: 6239:CELE_Y51H1A.5
uniprot id: Q9U266
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

6239:CELE C42C1.13
gene id: 6239:CELE_C42C1.13
uniprot id: A7IQW5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL21 family.
messages: Protein-lysine N-methyltransferase.

6239:CELE ZK593.4
gene id: 6239:CELE_ZK593.4
uniprot id: A0A061ACP3
uniprot id: Q23541
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:17320161). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20' (PubMed:17320161). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161). Required for normal longevity of the soma in a germline-dependent manner (PubMed:20555324, PubMed:22212395). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Involved in larval development and vulva formation (PubMed:17320161).
messages: Nucleus
messages: RNAi-mediated knockdown decreases lifespan in wild type worms with an intact germline (PubMed:20555324). Results in extended lifespan when egg production is inhibited by the addition of floxuridine (FUDR) or in a glp-1 mutant background which lacks a germline (PubMed:22212395, PubMed:20555324).

6239:CELE E04A4.4
gene id: 6239:CELE_E04A4.4
uniprot id: O44476
uniprot id: U4PR60
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RNase Z family.
messages: Does not regulate the mitochondrial unfolded protein response following mitochondrial stress.
messages: Highly expressed in the germline.
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus
messages: Plays a role in mitochondrial unfolded protein response (PubMed:35451962). Upon mitochondrial stress is exported from the nucleus where its tRNA endonuclease activity is negatively regulated (PubMed:35451962). In response to mitochondrial stress, might be involved in activating a transcriptional response in an ATFS-1- and DVE-1-dependent manner (PubMed:35451962). May play a role in negatively regulating the mitochondrial membrane potential (PubMed:35451962).
messages: RNAi-mediated knockdown attenuates the mitochondrial unfolded protein response as indicated by reduced expression of hsp-6.
messages: Up-regulated in response to mitochondrial stress.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:35451962). Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Involved in germline proliferation (PubMed:14729485). May be required for both mitosis and meiosis in germ cells (PubMed:14729485).

6239:CELE C07A12.1
gene id: 6239:CELE_C07A12.1
uniprot id: H2KYH4
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: During embryogenesis, expressed in HSN motor neurons (at protein level) (PubMed:10049362). Expressed in HSNs both before and during cell migration (at protein level) (PubMed:10049362).
messages: Nucleus
messages: Probable transcription factor that acts downstream of egl-15, to promote migration of the HSN motor neurons from the tail to the gonad primordium during HSN cell differentiation (PubMed:10049362).

6239:CELE F21F3.1
gene id: 6239:CELE_F21F3.1
uniprot id: P91268
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
messages: Secreted

6239:CELE Y50E8A.9
gene id: 6239:CELE_Y50E8A.9
uniprot id: Q9NAE9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE R07E5.1
gene id: 6239:CELE_R07E5.1
uniprot id: Q21827
names: Similarity
messages: Belongs to the GPATCH1 family.

6239:CELE T08B1.3
gene id: 6239:CELE_T08B1.3
uniprot id: O44555
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE Y23H5B.4
gene id: 6239:CELE_Y23H5B.4
uniprot id: Q9N476
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T07F8.2
gene id: 6239:CELE_T07F8.2
uniprot id: P91439
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F58B3.9
gene id: 6239:CELE_F58B3.9
uniprot id: G5EE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE D1014.7
gene id: 6239:CELE_D1014.7
uniprot id: M1ZJ39
uniprot id: M1ZMI7
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y76B12C.7
gene id: 6239:CELE_Y76B12C.7
uniprot id: Q9N4C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF1 family.
messages: CPSF is a heterotetramer composed of four distinct subunits 160 (cpsf-1), 100 (cpsf-2), 70 (cpsf-3), and 30 kDa (cpsf-4).
messages: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).
messages: Nucleus

6239:CELE Y54E10BR.6
gene id: 6239:CELE_Y54E10BR.6
uniprot id: Q9N3C9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

6239:CELE ZK185.2
gene id: 6239:CELE_ZK185.2
uniprot id: O44196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE F44A6.2
gene id: 6239:CELE_F44A6.2
uniprot id: P41830
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Most abundant in embryos.
messages: Nucleus
messages: RNAi-mediated knockdown results in 43% lethality of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown together with fox-1 results in hermaphrodite embryonic lethality (PubMed:21471153, PubMed:33372658). This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153). RNAi-mediated knockdown results in hermaphrodites lethality due to failure of the dosage compensation complex to assemble on X chromosomes in a fox-1 y303 mutant background (PubMed:17720939). RNAi-mediated knockdown in a background containing one copy of the fox-1 gene results in the viability of 3% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 1% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 7% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of the xol-1 gene have been mutated to AUACA results in the viability of 24% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA results in the viability of 18% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUAUA results in the viability of 33% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUAUA results in the viability of 13% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG …
messages: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:21471153, PubMed:23666922, PubMed:16139225, PubMed:17720939, PubMed:33372658). Directly binds to five 5'-A(G/C)(G/T)(T/G)C(A/G)-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922). Together with fox-1 is involved in making the distinction between one and two X-chromosomes (PubMed:21471153, PubMed:23666922, PubMed:33372658). Plays a role in the fox-1-mediated repression of the functionally active isoform (isoform b) of the sex-determining factor xol-1 gene to promote hermaphrodite development (PubMed:33372658). Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939).

6239:CELE C45G9.1
gene id: 6239:CELE_C45G9.1
uniprot id: Q09503
names: Caution
names: Domain
names: Similarity
messages: Although it belongs to the protein kinase family, lacks the active site Asp residue which has been changed to Asn so is unlikely to be catalytically active.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F58A6.4
gene id: 6239:CELE_F58A6.4
uniprot id: Q20958
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE W02D3.9
gene id: 6239:CELE_W02D3.9
uniprot id: O02482
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Interacts with unc-4 (PubMed:10557206). Interacts with ref-1 (PubMed:15935776). May interact with mls-1 (PubMed:21852953).
messages: Maternal effect embryonic lethal (PubMed:21852953). RNAi-mediated knockdown results in reduced uterine cell specification (PubMed:21852953). Descendants of the ABa blastomere express lag-2 ectopically (PubMed:15935776).
messages: Nucleus
messages: Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity (PubMed:9165118, PubMed:10557206, PubMed:17289921). In concert with unc-4, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate (PubMed:10557206, PubMed:17289921). May function with transcription factor mls-1 to promote uterine muscle specification and formation (PubMed:21852953).

6239:CELE F35H10.10
gene id: 6239:CELE_F35H10.10
uniprot id: G5ECZ3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T04A11.12
gene id: 6239:CELE_T04A11.12
uniprot id: P83502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sru family.
messages: Membrane

6239:CELE C52E12.2
gene id: 6239:CELE_C52E12.2
uniprot id: P23678
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
messages: Expressed in nerve ring, amphid commissure and ventral nerve cord (at protein level).
messages: Interacts with casy-1.
messages: Motor protein involved in microtubule-associated anterograde transport (PubMed:1846075, PubMed:29529030). Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons (PubMed:20510931). Regulates the polarized sorting of axonal proteins (PubMed:22101643). Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex (PubMed:21609829). Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons (PubMed:12657671). Involved in necrotic cell death (PubMed:22157748).
messages: Worms exhibit uncoordinated and slow movement.
messages: axon
messages: cytoskeleton

6239:CELE C16C10.7
gene id: 6239:CELE_C16C10.7
uniprot id: Q09463
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RNF5 family.
messages: Cell junction
messages: Cell membrane
messages: E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732). Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis (PubMed:20385102, PubMed:15210732). Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting (PubMed:20385102). Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439). Acts as a negative regulator of autophagy (PubMed:23093945).
messages: Expressed in body wall muscles.
messages: Expressed in larval stages L1, L2 and L3 and in adult animals with high expression during molting (at protein level).
messages: RNAi-mediated knockdown leads to disorganized muscle dense bodies and abnormal muscle-muscle cell boundaries. Accumulation of unc-95 in the muscle cell bodies.
messages: focal adhesion

6239:CELE M163.3
gene id: 6239:CELE_M163.3
uniprot id: P10771
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Cytoplasm
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures (Probable) (PubMed:23028351). Probably does not act as global transcriptional repressor (PubMed:23028351). Acting in concert with chromobox protein homologs hpl-1 and hpl-2, involved in reproduction, somatic gonad development, male tail development, and vulval cell fate decisions; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5 (PubMed:23028351). Plays a role in linking epigenetic regulation with the innate immune response (PubMed:22083954).
messages: Interacts with nmad-1 (PubMed:31283754). Interacts (when monomethylated at Lys-14) with chromobox protein homolog hpl-1; the interaction is direct (PubMed:23028351). Interacts (when monomethylated at Lys-14) with histone H3 (when trimethylated on 'Lys-27'); the interaction is direct (PubMed:23028351).
messages: Methylation at lysine 14 is necessary to regulate male tail development.
messages: Nucleus

6239:CELE F42G2.6
gene id: 6239:CELE_F42G2.6
uniprot id: O17102
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C01G10.14
gene id: 6239:CELE_C01G10.14
uniprot id: Q93173
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y47D9A.1
gene id: 6239:CELE_Y47D9A.1
uniprot id: Q9N4V2
uniprot id: Q9N4V3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

6239:CELE F15B10.2
gene id: 6239:CELE_F15B10.2
uniprot id: G5EDI8
names: Similarity
messages: Belongs to the helicase family. RLR subfamily.

6239:CELE F22B7.2
gene id: 6239:CELE_F22B7.2
uniprot id: P34405
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Secreted
messages: The protein was originally predicted to include a TKFQDFLRF-amide peptide, although TKFQDFLRF-amide has no effect on the activity of dissected pharyngeal myogenic muscle system.

6239:CELE Y69E1A.4
gene id: 6239:CELE_Y69E1A.4
uniprot id: Q9XW33
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE T07A5.3
gene id: 6239:CELE_T07A5.3
uniprot id: Q10046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
messages: Membrane

6239:CELE Y62E10A.12
gene id: 6239:CELE_Y62E10A.12
uniprot id: Q9U1W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

6239:CELE T05E11.3
gene id: 6239:CELE_T05E11.3
uniprot id: Q22235
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adults show increased sensitivity to cisplatin, sodium arsenite and zinc. RNAi-mediated knockdown results in induction of the unfolded protein response.
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Molecular chaperone that functions in the processing and transport of secreted proteins.

6239:CELE D2024.8
gene id: 6239:CELE_D2024.8
uniprot id: Q18975
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE W06D4.4
gene id: 6239:CELE_W06D4.4
uniprot id: Q9XW42
names: Function
names: Similarity
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.

6239:CELE K08F8.6
gene id: 6239:CELE_K08F8.6
uniprot id: Q93442
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex (By similarity). Interacts with sur-2/mdt-23 and let-425/mdt-6.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for asymmetric division of T-cells and for hypodermal development.
messages: Nucleus
messages: Ubiquitously expressed in larvae and embryos.
messages: Widely expressed in most adult tissues including the vulva, tail neurons, skeletal muscle, hypodermal cells, the excretory canal and pharynx.

6239:CELE T20H4.1
gene id: 6239:CELE_T20H4.1
uniprot id: A0A168H2S6
uniprot id: Q22622
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE H02I12.1
gene id: 6239:CELE_H02I12.1
uniprot id: O45599
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.
messages: RNAi-mediated knockdown causes the zygote to exit the spermatheca with a pinched morphology and to leave a trailing section behind. Zygotes have a fragmented chitin eggshell with an accumulation of chitin at one end of the embryo, causing polyspermy. In unfertilized oocytes, disrupts the homogenous distribution of cortical chitin synthase chs-1, pseudophosphatase egg-3 and kinase mbk-2 and causes the loss of egg-1 and egg-2 cell membrane localization resulting in their premature accumulation in cytoplasmic puncta.
messages: extracellular matrix

6239:CELE Y52E8A.6
gene id: 6239:CELE_Y52E8A.6
uniprot id: I7LFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE F14B8.7
gene id: 6239:CELE_F14B8.7
uniprot id: Q95QL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE H15N14.1
gene id: 6239:CELE_H15N14.1
uniprot id: Q9U3D6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Can prevent somatic transgenes from inducing gene silencing via the RNA interference pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.
messages: Cytoplasm
messages: Expression begins early in embryogenesis where it is detected in late gastrula and comma stage embryos. By the comma stage, expression is highest in developing neuronal tissue in the head, tail and ventral side. Neuronal expression continues through embryogenesis and, by the L1 larval stage, is the prominent pattern. Expressed in most, if not all, cells of the nervous system at all larval stages and in adult animals. Also expressed in the developing vulva but not expressed in the adult vulva.
messages: Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood.
messages: Interacts with double-stranded RNA-specific adenosine deaminase adr-2.
messages: Nucleus
messages: Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines (PubMed:24508457, PubMed:25373143). Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs (PubMed:24508457). Represses editing efficiency of the Y75B8A.8 3' UTR in neurons (PubMed:26917557). Required for correct expression and A-to-I editing of clec-41 (PubMed:28925356). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Also required for normal vulva development (PubMed:12426375). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).

6239:CELE F35E8.11
gene id: 6239:CELE_F35E8.11
uniprot id: G5EE89
names: Similarity
messages: Belongs to the FAX family.

6239:CELE W09B6.4
gene id: 6239:CELE_W09B6.4
uniprot id: B9DF69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE C06E1.7
gene id: 6239:CELE_C06E1.7
uniprot id: P34302
names: Similarity
messages: Belongs to the glycosyltransferase 11 family.

6239:CELE F39C12.2
gene id: 6239:CELE_F39C12.2
uniprot id: Q9U9K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Cell membrane
messages: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in time-dependent memmory loss and the retention of conditioned behavior over time (PubMed:24630719).
messages: cytoskeleton

6239:CELE T07F12.1
gene id: 6239:CELE_T07F12.1
uniprot id: Q22323
names: Function
names: Subcellular Location Annotation
messages: Phosphatase that dephosphorylates some steroids such as ecdysone 22-phosphate (E22P), 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) in vitro (PubMed:17348005). Also displays acid phosphatase activity towards 4-nitrophenyl phosphate (pNNP) in vitro (PubMed:17348005). Has no activity towards 3-epi-ecdysone 3-phosphate (E3P) in vitro (PubMed:17348005).
messages: cytosol

6239:CELE ZK1127.10
gene id: 6239:CELE_ZK1127.10
uniprot id: P55216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the trans-sulfuration enzymes family.
messages: Cytoplasm

6239:CELE EEED8.1
gene id: 6239:CELE_EEED8.1
uniprot id: Q09293
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Promotes the biogenesis of 21U-RNAs (PubMed:31216475). Required for chromosome segregation and cell division in early embryos (PubMed:17171368, PubMed:31216475). May have a role in DNA replication (PubMed:17171368).
messages: Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the pid-1 variant of the PETISCO complex interacts with pid-1 (PubMed:31216475). Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex interacts with tost-1 (PubMed:31216475). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via C-terminus) with ife-3 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via the RRM domain) with pid-3 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via the RRM domain) with erh-2 (PubMed:31216475). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of 21U-RNAs (PubMed:31147388).
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Relatively high levels of expression in early embryos, weakly detectable in subsequent developmental stages and enriched in adults (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475).
messages: Expression is restricted to the germline (at protein level).
messages: Nucleus
messages: Worms whose mothers are lacking mel-47 exhibit prolonged interphase between the two and four cell stages of development. Mutants arrest as early embryos ranging from 50 to 80 cells with no signs of morphogenesis. Chromatin bridges which connect nuclei remain present after cytokinesis appears complete. RNAi-mediated knockdown results in maternal effect lethal (Mel phenotype) (PubMed:31147388). RNAi-mediated knockdown results in chromosome segregation and cell division defects in early embryos (PubMed:31216475). RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown results in the failure of pid-1, pid-3 and erh-2 to localize to perinuclear granules, but instead they accumulate in the nucleus (PubMed:31216475).
messages: perinuclear region

6239:CELE B0361.7
gene id: 6239:CELE_B0361.7
uniprot id: Q10944
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE K12H4.2
gene id: 6239:CELE_K12H4.2
uniprot id: P34523
names: Similarity
messages: Belongs to the Iojap/RsfS family.

6239:CELE DY3.2
gene id: 6239:CELE_DY3.2
uniprot id: Q21443
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Expressed throughout the development and in adults.
messages: Interacts with LEM domain proteins lem-2 and emr-1 (PubMed:11870211, PubMed:12684533). May interact with unc-84; this interaction may be required to complete the connection between the nuclear lamina and the cytoskeleton (PubMed:25057012).
messages: It is the only lamin protein in C.elegans.
messages: Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012). Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012). Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918). Involved in spatial organization of nuclear pore complexes (PubMed:11071918). It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans (PubMed:12064941).
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: RNAi-mediated knockdown results in the irregular localization of nuclear envelope associated proteins such as unc-84 (PubMed:11870211). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:25057012).
messages: Ubiquitous. Expressed in all cells, except in cells undergoing spermatogenesis.

6239:CELE Y32B12C.2
gene id: 6239:CELE_Y32B12C.2
uniprot id: Q9XX07
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C48B6.8
gene id: 6239:CELE_C48B6.8
uniprot id: O01514
names: Disruption Phenotype
names: Function
names: Subunit
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:22022287, PubMed:22922713). In ciliated sensory neurons, required for the sensation of nitric oxide and avoidance of NO-producing organisms like P.aeruginosa (PubMed:30014846).
messages: Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements (PubMed:22022287). Defective cilia structure and function characterized by an increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:22922713). Disrupted assembly of the BBSome complex at the base of the cilia (PubMed:22922713). Defective avoidance of nitric oxide and P.aeruginosa (PubMed:30014846).
messages: Part of BBSome complex, that contains bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity). Interacts with bbs-1 (PubMed:22922713).

6239:CELE C32E8.3
gene id: 6239:CELE_C32E8.3
uniprot id: P91127
names: Function
names: Similarity
messages: Belongs to the TPPP family.
messages: Regulator of microtubule dynamics.

6239:CELE Y48A6B.11
gene id: 6239:CELE_Y48A6B.11
uniprot id: G5EFV3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with phosphatase regulatory subunit rsa-1 and tpxl-1 (PubMed:17218259). May interact with spd-5 (PubMed:17218259). May interact with sys-1 (PubMed:25819561).
messages: RNAi-mediated knockdown causes defects in spindle assembly characterized by kinetochore microtubule instability, a reduction in centrosomal microtubules and a decrease in outgrowth of microtubule plus ends from centrosomes (PubMed:17218259). Also causes a reduction of sys-1/beta-catenin enrichment at centrosomes throughout early embryonic cleavages (PubMed:25819561). Increases sys-1 nuclear accumulation without affecting sys-1 asymmetric distribution in E and MS blastomers (PubMed:25819561).
messages: Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes (PubMed:17218259). Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions (PubMed:25819561).
messages: centrosome

6239:CELE K10G6.3
gene id: 6239:CELE_K10G6.3
uniprot id: A0A0K3AUE4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in seam cells, intestine cells, pharyngeal muscles and nerve ring neurons.
messages: In embryos, expressed in 20- to 30-cell stage and expression decreases after the 200-cell stage (PubMed:23666922). Expressed in seam cells, intestine cells, pharyngeal muscles and nerve ring neurons in L3 stage larvae and expression persists into adults (PubMed:21471153).
messages: Nucleus
messages: RNA-binding protein, which regulates the expression of proteins required to control developmental timing of events during the L2 to L3 larval stage switch (PubMed:21471153). Binds to the 3'UTR of the transcript of the heterochronic protein lin-28 to post-transcriptionally negatively regulate its expression in certain tissue types in the later larval stages (PubMed:21471153). During larval development, controls the timing of seam cell division and terminal differentiation into adult alae (PubMed:21471153). In vitro, it can also bind to DNA through its first zinc finger (PubMed:21471153). May bind directly or indirectly to the promoter of the sex-determining factor xol-1 to activate its transcription (PubMed:23666922). Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development (PubMed:23666922). Through the negative regulation of lin-28 transcript, it also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153). Acts in the intestine to play a role in regulating adult lifespan (PubMed:21471153).
messages: RNAi mediated knockdown at early larval stages and in young adults results in an extended lifespan (PubMed:21471153). RNAi-mediated knockdown results in delayed developmental defects with an increased number of seam cells in young adults (PubMed:21471153). RNAi-mediated knockdown suppresses the embryonic lethality of hermaphrodites in the double fox-1 y303 and sex-1 y263 mutant background (PubMed:23666922).
messages: The Zinc finger domains 1 and 5 bind single-stranded and double-stranded RNAs (PubMed:21471153). The Zinc finger domain 1 binds DNA in vitro (PubMed:21471153).

6239:CELE F15H10.2
gene id: 6239:CELE_F15H10.2
uniprot id: P20631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE C25H3.6
gene id: 6239:CELE_C25H3.6
uniprot id: H2KYV0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C18A3.3
gene id: 6239:CELE_C18A3.3
uniprot id: Q09958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

6239:CELE Y57A10B.3
gene id: 6239:CELE_Y57A10B.3
uniprot id: Q9XWH8
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F25B3.3
gene id: 6239:CELE_F25B3.3
uniprot id: K8FDZ6
uniprot id: Q19770
names: Similarity
messages: Belongs to the RASGRP family.

6239:CELE Y48G1BL.2
gene id: 6239:CELE_Y48G1BL.2
uniprot id: Q9N3Q4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Increased sensitivity to ionizing radiation with reduced survival compared to wild-type animals. Loss of induction of apoptosis following UV-C or ionizing radiation treatment but no effect on apoptotic response induced by X-ray exposure. Low brood size, reduced viability and sterility, appearance of a high-incidence-of-males (Him) phenotype, and reduced chromosome number due to chromosome fusions.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability.

6239:CELE C03G6.19
gene id: 6239:CELE_C03G6.19
uniprot id: G5EFH4
names: Similarity
messages: Belongs to the serpin family.

6239:CELE F49H12.1
gene id: 6239:CELE_F49H12.1
uniprot id: Q9N5S3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed ubiquitously (PubMed:16291785). Earliest expression is at the 50-cell stage, and persists throughout embryogenesis, larval stages and adulthood (PubMed:16291785).
messages: Involved in transcriptional regulation (By similarity). Required to specify left-right asymmetry of the ASE gustatory neurons, probably acting upstream of microRNA lsy-6 (PubMed:16291785, PubMed:26050091). Involved in maintaining the distinction between somatic and germ cells, perhaps acting by repressing germ cell-specific genes in somatic cells (PubMed:26050091).
messages: Nucleus speckle
messages: RNAi-mediated knockdown causes ectopic expression of gcy-5 in the ASEL gustatory neuron.

6239:CELE T06E4.6
gene id: 6239:CELE_T06E4.6
uniprot id: Q22260
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y71G12B.8
gene id: 6239:CELE_Y71G12B.8
uniprot id: Q95XM9
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE ZK180.4
gene id: 6239:CELE_ZK180.4
uniprot id: Q23445
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Also plays a role in transporting the tyrosine kinase receptor let-23 from the endoplasmic reticulum to the plasma membrane of vulval precursor cells (PubMed:32053105).
messages: RNAi-mediated knockdown results in the reduced plasma membrane localization and intracellular accumulation of the tyrosine kinase receptor let-23 in vulval precursor cells.

6239:CELE R09H10.3
gene id: 6239:CELE_R09H10.3
uniprot id: Q21882
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

6239:CELE B0272.2
gene id: 6239:CELE_B0272.2
uniprot id: P41941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Part of a unique SNARE complex.
messages: cis-Golgi network membrane

6239:CELE F52E1.4
gene id: 6239:CELE_F52E1.4
uniprot id: H2L002
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed asymmetrically in ASE left (ASEL) sensory neuron (PubMed:16099833, PubMed:16547101). Expressed in excretory canal cell (PubMed:16547101).
messages: Expressed in both ASEL and ASER neurons throughout late embryonic and early larval stages.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F25H8.6
gene id: 6239:CELE_F25H8.6
uniprot id: Q19787
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in neuronal cell bodies in the ventral cord and HSN neurons.
messages: Expressed in the lateral hypodermal (seam) cells and occasionally in the hyp7 hypodermal cell during the larval stages of development with increased expression during the molting phase between the L3 and L4 stages of larval development. Also expressed in the vulval precursor cell desecendents of P5.p, P6.p and P7.p cells.
messages: Nucleus
messages: Probable transcription factor (PubMed:20005870, PubMed:24885717). Involved in vulval organogenesis (PubMed:20005870, PubMed:24885717). During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1 (PubMed:20005870). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717). Plays a role in larval molting (PubMed:20005870).
messages: RNAi-mediated knockdown results in an egg-laying defect and vulval cell-lineage defects including failed division of vulval precursor cell descendents (PubMed:20005870). RNAi-mediated knockdown causes a decrease in expression of lin-39 at the larval L3 stage (PubMed:24885717). Knockdown in L1 stage larvae, in a lin-39 mutant background, causes abnormal fusion of vulval precursor cells at larval stage L2 (PubMed:24885717).

6239:CELE C11D2.4
gene id: 6239:CELE_C11D2.4
uniprot id: O45069
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

6239:CELE C33C12.3
gene id: 6239:CELE_C33C12.3
uniprot id: O16580
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

6239:CELE R09F10.4
gene id: 6239:CELE_R09F10.4
uniprot id: Q23027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C18H7.4
gene id: 6239:CELE_C18H7.4
uniprot id: Q9GZG1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F59B2.2
gene id: 6239:CELE_F59B2.2
uniprot id: P34479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic granule
messages: Expressed in the head, tail, body and ventral nerve cord neurons, muscles of the vulva, and intestine.
messages: Membrane
messages: Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin.

6239:CELE Y43F8C.12
gene id: 6239:CELE_Y43F8C.12
uniprot id: Q9U2G5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Expressed in head neurons, including the dopamine (DA) motor neuron, and other cells in the body.
messages: Negatively regulates cellular toxicity by mediating the export of environmental toxicants such as methylmercury out of the cell (PubMed:24266639). Plays a role in inhibiting methylmercury-induced dopamine (DA) motor neuron degeneration (PubMed:24266639). Not involved in Mn(2+)- or Al(3+)-associated toxicity (PubMed:24266639).
messages: RNAi-mediated knockdown results in increased death in response to the environmental toxicant methylmercury (PubMed:24266639). Furthermore, in response to methylmercury, RNAi-mediated knockdown results in the accumulation of the methylmercury in cells, the subsequent increase of gst-1, hsp-4, hsp-6, and hsp-16.1 gene expression, and in dopamine (DA) motor neuron degeneration (PubMed:24266639).
messages: Up-regulated in response to environmental toxicants such as methylmercury.

6239:CELE E04F6.5
gene id: 6239:CELE_E04F6.5
uniprot id: Q19057
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE C49H3.8
gene id: 6239:CELE_C49H3.8
uniprot id: Q9GYR2
names: Similarity
messages: Belongs to the actin family.

6239:CELE F11C1.4
gene id: 6239:CELE_F11C1.4
uniprot id: Q19347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

6239:CELE B0564.3
gene id: 6239:CELE_B0564.3
uniprot id: Q17528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE K11G12.3
gene id: 6239:CELE_K11G12.3
uniprot id: Q21433
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the NRAMP family.
messages: Cytoplasmic vesicle membrane
messages: Expressed in dopaminergic neurons (at protein level) (PubMed:19801673). Primarily expressed in mc1, mc2 and mc3 epithelial cells of the pharynx and vpil-6 pharyngeal-intestinal valve cells displaying an anterior-posterior expression gradient (PubMed:19924247). Expressed in gonad sheath cells (PubMed:19924247).
messages: Increased mortality rate and increased body levels of Mn(2+) when Mn(2+) levels are high in the environment (PubMed:19924247, PubMed:19785996). Reduced survival rate in response to infection mediated by pathogenic bacterium S.aureus (PubMed:19785996). Iron levels are low, independently of Mn(2+) levels (PubMed:19924247). RNAi-mediated knockdown partially prevents CEP neuron death mediated by the neurotoxin 6-hydroxy dopamine (6-OHDA) but not when mediated by high levels of Mn(2+) (PubMed:19801673).
messages: Probable divalent metal ion transporter which regulates Mn(2+) uptake.
messages: Slightly repressed by high levels of Mn(2+) (PubMed:19801673, PubMed:19924247).

6239:CELE T23H2.1
gene id: 6239:CELE_T23H2.1
uniprot id: P91495
names: Similarity
messages: Belongs to the NUP210 family.

6239:CELE C34C6.1
gene id: 6239:CELE_C34C6.1
uniprot id: Q18428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE ZK154.3
gene id: 6239:CELE_ZK154.3
uniprot id: P12456
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Defective touch receptor neuron synaptic transmission with reduced levels of rab-3 at synapses, conferring touch insensitivity. Irregular touch receptor neuron shape. The heterozygous mutant, but not the null mutant, rescues the touch sensitivity defect in the mec-15 single mutant.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Expressed primarily in touch receptor neurons.
messages: Mec-7 beta-tubulin is required for the production of 15-protofilament microtubules.
messages: TTubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:19652181).
messages: cytoskeleton

6239:CELE R04A9.4
gene id: 6239:CELE_R04A9.4
uniprot id: Q21693
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Expressed at the 2-fold embryonic stage and throughout larval stages and adulthood.
messages: Highly expressed in all somatic tissues.
messages: RNAi-mediated knockdown increases lifespan. Lifespan is further increased in an age-1 hx546, daf-2 e1370, clk-1 qm30 or eat-2 ad465 mutant background.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps (PubMed:10744754, PubMed:9553113). Probably by regulating mRNA translation in somatic cells, negatively regulates lifespan independently of daf-2/insulin and let-363/TOR pathways (PubMed:17277769). Negatively regulates resistance to oxidative stress (PubMed:17277769). May play a role in embryonic development (PubMed:17277769).
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.

6239:CELE ZK856.12
gene id: 6239:CELE_ZK856.12
uniprot id: Q23647
names: Domain
names: Subcellular Location Annotation
messages: Tudor domain specifically binds peptides with symmetrically dimethylated arginines (sDMA) and may facilitate protein-protein interactions.
messages: perinuclear region

6239:CELE F18G5.4
gene id: 6239:CELE_F18G5.4
uniprot id: P54245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Possible acetylcholine receptor.
messages: Postsynaptic cell membrane

6239:CELE R13D11.6
gene id: 6239:CELE_R13D11.6
uniprot id: A0A0K3ASU2
uniprot id: O17010
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F55C10.1
gene id: 6239:CELE_F55C10.1
uniprot id: G5EDN6
uniprot id: H9G2Y1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family.
messages: Cytoplasm
messages: Expressed in sperm, spermatids, spermatheca, male gonads, intestine, nerve cord, hypodermal seam cells, cuticle and excretory canal.
messages: Forms a complex composed of a calmodulin-dependent catalytic subunit tax-6 (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit cnb-1 (also known as calcineurin B) which confers calcium sensitivity.
messages: Mutants grow slowly and show uncoordinated or lethargic movements (PubMed:12221132, PubMed:12684004). Increased lifespan (PubMed:19279398). Body is small and slender with a transparent appearance resulting from a thinner cuticle (PubMed:12221132, PubMed:12684004). Reduced number of progeny associated with a retention of late stage embryos in the uterus, a reduced sperm count which appears smaller and smoother and with smaller pseudopods (PubMed:12221132, PubMed:12684004). In addition, serotonin-induced egg laying is delayed (PubMed:12221132, PubMed:12684004). Increased susceptibility to nicotine-mediated paralysis (PubMed:15990870). Impaired CO2 avoidance (PubMed:18524955). Increased number of puncta positive for autophagy marker LGG-1 (PubMed:19279398). Impaired coelomocyte endocytosis, intestinal apical endocytosis and recycling of synaptic vesicles at synapses (PubMed:20803083, PubMed:21345307).
messages: Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132). Confers calcium sensitivity (PubMed:12221132). Plays a role in egg-laying, fertility, growth, movement and cuticle development (PubMed:12221132, PubMed:12684004). Plays a role in sensitivity to CO2 levels (PubMed:18524955). Regulates expression of tax-6 inhibitor rcn-1 (PubMed:12684004). Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870). Negatively regulates lifespan (PubMed:19279398). Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307). May negatively regulate autophagy (PubMed:19279398).

6239:CELE Y73B6BL.30
gene id: 6239:CELE_Y73B6BL.30
uniprot id: Q95XD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S2 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE T26A5.5
gene id: 6239:CELE_T26A5.5
uniprot id: Q95Q98
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan.
messages: Nucleus
messages: RNAi-mediated knockdown introduced at L1 and young adult stages increases lifespan by 12% and 15% respectively.
messages: The JmjC domain mediates the demethylation activity.

6239:CELE F52G2.1
gene id: 6239:CELE_F52G2.1
uniprot id: O62255
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.
messages: Cytoplasmic granule
messages: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:16199859). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:16199859). RNA-decapping enzyme although it does not bind the RNA cap (PubMed:16199859). May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs (PubMed:16199859). In oocytes, may play a role in the response to stress induced by heat shock, osmotic stress and anoxia (PubMed:18439994). Required for the developmental axon guidance and regrowth of PLM touch receptor neurons (PubMed:31983639). Early in embryogenesis, plays a role in ciliary shape formation in sensory neurons (PubMed:28887031). Promotes survival at high temperatures (PubMed:25061667).
messages: Double RNAi-mediated knockdown with dcap-1 reduces survival at 20 degrees Celsius.
messages: Expressed in sensory neurons.
messages: Inhibited by capped and uncapped RNA (PubMed:16199859). Not inhibited by dinucleotide cap or methylated nucleotide analogs (PubMed:16199859).
messages: May be a component of the decapping complex composed of dcap-1 and dcap-2.
messages: perinuclear region

6239:CELE W06B4.3
gene id: 6239:CELE_W06B4.3
uniprot id: Q23194
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Early endosome
messages: In hermaphrodites, expressed in coelomocytes and gonadal sheath cells.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (PubMed:25273556, PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in intestinal cells of the embryo, and also promotes the trafficking of embryonic intestinal gut granules away from lysosomes (PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:18923146, PubMed:26783301). Plays a role in the degradation of apoptotic cells during programmed cell death (PubMed:18923146).
messages: Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2.
messages: Temperature-sensitive defects in the formation of gut granules during embryogenesis (PubMed:24501423). At 15 degrees Celsius, pretzel-stage embryos have a reduced number of gut granules in intestinal cells, and at 22 degrees Celsius, pretzel-stage embryos completely lack gut granules in intestinal cells (PubMed:24501423). At 25 degrees Celsius, many embryos arrest by the pre-bean stage before elongation, and 76% of these embryos contain gut granules irregularly distributed throughout the embryo (PubMed:24501423). Defective apoptotic germ cell corpse digestion with delayed degradation of chromatin in late germ cell corpses (PubMed:18923146). This results in increased numbers of germ cell corpses at 20 degrees Celsius during embryogenesis and post the L4 stage of larval development, and furthermore the retention of cell corpses for a longer duration of time (PubMed:18923146). Impaired formation of endosomes and lysosomes in coelomocytes, in particular there is impaired formation of recycling endosomes (PubMed:18923146). In addition, there are endosome/lysosome fusion defects in coelomocytes (PubMed:18923146, PubMed:26783301). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556). Double knockout with either sorf-1 or sorf-2, results in larger endosomes and larger lysosomes and thus suppresses the endosome/lysosome fusion defect in the vps-18 single mutant (PubMed:26783301).
messages: Ubiquitously expressed in embryos. In early larvae, expressed in hypodermal cells, seam cells and body wall muscle cells.
messages: autophagosome
messages: clathrin-coated vesicle

6239:CELE R160.1
gene id: 6239:CELE_R160.1
uniprot id: P35603
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).
messages: Belongs to the adapter complexes medium subunit family.
messages: Brain, heart, lung, liver, testis and spleen.
messages: Cell membrane
messages: Component of the adapter complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adapter (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells (PubMed:18160346, PubMed:18160347). Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells (PubMed:18160346, PubMed:18160347). During development, regulates the migration of HSN neurons and the left and right Q neuroblasts (QL and QR, respectively) and their descendants, possibly through hox gene and wnt/egl-20 gene target mab-5, and plays a role in establishing ALM and PLM neuronal cell polarity (PubMed:18160346). Regulates AWB sensory neuron cilia membrane expansion during development, potentially via localization of tub-1 and PtdIns(4,5)P2 to the ciliary base (PubMed:31259686). Required for the asymmetric divisions of V5 cells (PubMed:18160346).
messages: Mutants display a squat body statue referred to as a dumpy phenotype and have defective HSN neuronal cell migration (PubMed:18160346). AWB sensory neurons show an expanded ciliary membrane phenotype with enhanced wing cilia and relocalized tub-1 and PtdIns(4,5)P2 to the ciliary base (PubMed:31259686). RNAi-mediated knockdown results in impaired function of the AP-2 complex and accumulation of the wntless homolog mig-14 at the cell membrane (PubMed:18160347).
messages: coated pit

6239:CELE F22D3.2
gene id: 6239:CELE_F22D3.2
uniprot id: J7S130
uniprot id: K0M7B5
uniprot id: S6FCY3
uniprot id: S6FMZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

6239:CELE C40C9.2
gene id: 6239:CELE_C40C9.2
uniprot id: Q18556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE Y106G6E.1
gene id: 6239:CELE_Y106G6E.1
uniprot id: G5EFV1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE F42D1.3
gene id: 6239:CELE_F42D1.3
uniprot id: Q93704
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in head neurons including the ASE sensory neurons and the ASI and AWB chemosensory neurons, the midbody neurons SDQ, and motor neurons in the tail.
messages: G-protein coupled receptor for the neuropeptide like protein nlp-38 (PubMed:30779740). Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning (PubMed:30779740). Its role in salt avoidance learning may be through activation of the transcription factor crh-1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory (PubMed:30779740).

6239:CELE C11D2.2
gene id: 6239:CELE_C11D2.2
uniprot id: O45072
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C55C3.1
gene id: 6239:CELE_C55C3.1
uniprot id: Q18869
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE Y42H9AR.2
gene id: 6239:CELE_Y42H9AR.2
uniprot id: Q9N3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6239:CELE Y92H12BL.5
gene id: 6239:CELE_Y92H12BL.5
uniprot id: Q95XC4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

6239:CELE ZK1037.5
gene id: 6239:CELE_ZK1037.5
uniprot id: O45987
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y110A7A.17
gene id: 6239:CELE_Y110A7A.17
uniprot id: Q9N593
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the APC3/CDC27 family.
messages: Expressed in the ventral nerve cord.
messages: Nucleus
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870).
messages: RNAi-mediated knockdown results in defective metaphase to anaphase transition (Mat phenotype) and embryos that arrest at the one-cell stage.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE C07A12.3
gene id: 6239:CELE_C07A12.3
uniprot id: Q17771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y62E10A.10
gene id: 6239:CELE_Y62E10A.10
uniprot id: Q9U1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane

6239:CELE D1005.2
gene id: 6239:CELE_D1005.2
uniprot id: Q18910
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

6239:CELE K03E6.6
gene id: 6239:CELE_K03E6.6
uniprot id: Q21193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
messages: In embryos, expression is specifically detected in body wall muscle cells. In adults, expression is localized to a striking dot-like fashion in body wall muscle.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

6239:CELE F21F3.7
gene id: 6239:CELE_F21F3.7
uniprot id: Q7JNC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

6239:CELE Y37E11AM.3
gene id: 6239:CELE_Y37E11AM.3
uniprot id: U4PBL3
uniprot id: U4PM16
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F23H11.2
gene id: 6239:CELE_F23H11.2
uniprot id: O01914
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

6239:CELE T12E12.6
gene id: 6239:CELE_T12E12.6
uniprot id: A5A631
names: Similarity
messages: Belongs to the peptidase M1 family.

6239:CELE Y71H2AM.23
gene id: 6239:CELE_Y71H2AM.23
uniprot id: G5ECM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

6239:CELE F53G12.7
gene id: 6239:CELE_F53G12.7
uniprot id: O01799
uniprot id: V6CM19
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F22D6.9
gene id: 6239:CELE_F22D6.9
uniprot id: Q27494
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F22B5.7
gene id: 6239:CELE_F22B5.7
uniprot id: G5EEM5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOG/XMAP215 family.
messages: Cytoplasm
messages: Expressed maternally during oogenesis. Observed during mitotic cell cycle from interphase through to early anaphase.
messages: Interacts with tac-1 to form a heterodimer.
messages: Maternal-effect embryonic lethal with meiotic and mitotic spindle positioning defects in one-cell stage embryos. RNAi-mediated knockdown results in meiosis and mitosis defects in embryos whereby embryos have one or both polar bodies absent, more than one female pronucleus and display irregular female pronuclear migration, which leads to delayed association with the male pronucleus (PubMed:16971515). RNAi-mediated knockdown results in defective mitotic spindle positioning and rotation in which spindles are established in the posterior side of the embryo and on the wrong axis (PubMed:16971515). RNAi-mediated knockdown results in a decrease in length of astral microtubules in embryos, with fewer microtubules extending from their centrosomes during cold conditions (PubMed:16971515). RNAi-mediated knockdown in a let-711 heteroallelic s2587 and it150 mutant background results in inviable embryos which do not hatch, however the astral microtubule length, polar body, female pronuclear migration and mitotic spindle defects of the single zyg-9 RNAi mutant are partially suppressed (PubMed:16971515).
messages: Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos (PubMed:16971515). Required for default nucleus positioning in oocytes (PubMed:16971515).
messages: The TOG (tumor overexpressed gene) domains are arranged in the N-terminal region with each domain composed of six (for the most part non-canonical) HEAT repeats and forming a oblong paddle-like structure. 3D-structure analysis shows the presence of additional HEAT repeats that are not detected by sequence-based prediction programs. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
messages: centrosome
messages: spindle pole

6239:CELE Y74C10AR.1
gene id: 6239:CELE_Y74C10AR.1
uniprot id: Q965S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE C43H6.8
gene id: 6239:CELE_C43H6.8
uniprot id: Q18590
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in sensory head neurons of the lateral ganglion.
messages: Nucleus
messages: RNAi-mediated knockdown extends mean lifespan and reduces expression of bcat-1 by >50%.
messages: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (By similarity). Involved in modulating physiological aging, probably by regulating expression of branched-chain amino acid transferase-1, bcat-1 (PubMed:26620638, PubMed:32203922).

6239:CELE C47E8.5
gene id: 6239:CELE_C47E8.5
uniprot id: Q18688
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 90 family.
messages: Highly expressed throughout development.
messages: Homodimer (PubMed:26593036). Interacts (via TPR repeat-binding and central region) with pph-5 (via phosphatase domain); the interaction promotes pph-5 phosphatase activity (PubMed:26593036). Interacts (via central region) with co-chaperone cdc-37 (via N-terminus); the interaction inhibits daf-21 ATPase activity (PubMed:23569206).
messages: In the embryo comma stage, expression is strongly detected in cells of the head region and less so in other areas. In early larvae, expressed in postembryonic germ cells derived from Z2 and Z3 cells and the head region, in both hermaphrodites and males. Under heat stress conditions, larval expression is not only detected in germ cells, but also all over the body. In adult hermaphrodites, expression is localized uniquely in the germ cells.
messages: Induced by heat-stress.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. In response to cellular stress, up-regulated in distal tissues in a pqm-1-dependent manner, preventing protein misfolding and maintaining proteostasis (PubMed:29949773). By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons (PubMed:10790386, PubMed:7828815). Participates in the control of cell cycle progression at the prophase/metaphase transition in oocyte development by ensuring the activity of wee-1.3 kinase, which negatively regulates cdk-1 through its phosphorylation (PubMed:16466390). Regulates yap-1 nuclear export after heat shock treatment (PubMed:23396260).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: perinuclear region

6239:CELE K07B1.2
gene id: 6239:CELE_K07B1.2
uniprot id: O01884
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE C04F6.3
gene id: 6239:CELE_C04F6.3
uniprot id: Q11174
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

6239:CELE R10D12.7
gene id: 6239:CELE_R10D12.7
uniprot id: Q9XVJ8
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE F09E5.8
gene id: 6239:CELE_F09E5.8
uniprot id: P52057
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

6239:CELE F43H9.2
gene id: 6239:CELE_F43H9.2
uniprot id: Q20375
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.
messages: Heterodimer of sptl-1/sptl-2.

6239:CELE K04G2.6
gene id: 6239:CELE_K04G2.6
uniprot id: Q21225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Microsome membrane

6239:CELE F43H9.4
gene id: 6239:CELE_F43H9.4
uniprot id: Q95ZT6
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

6239:CELE C09B9.3
gene id: 6239:CELE_C09B9.3
uniprot id: Q17851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Membrane

6239:CELE B0222.4
gene id: 6239:CELE_B0222.4
uniprot id: Q17456
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE R06C7.8
gene id: 6239:CELE_R06C7.8
uniprot id: Q21776
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
messages: Embryonic lethal (PubMed:25987605). RNAi-mediated knockdown in oocytes results in aberrant homologous chromosome segregation during meiosis due to severe pre-anaphase spindle defects characterized by disorganized microtubule bundles (PubMed:20729837). Delays in the processes leading up to exit from mitosis including delayed activation of separase, which results in a delay in the separation of sister chromatids, delayed cytokinesis onset and delayed chromosome decondensation (PubMed:25987605). These culminate in a delay in the onset of anaphase with a 50% increase in the interval between nuclear envelope breakdown and the onset of anaphase during embryogenesis (PubMed:25987605). Reduced bub-3 localization at the kinetochore region of chromosomes in embryos, but without a reduction in bub-3 protein (PubMed:25987605). In addition there is reduced localization of the spindly-like protein spdl-1 to kinetochores (PubMed:18765790).
messages: Expressed throughout embryogenesis mainly in dividing cells.
messages: Interacts (via kinase domain) with mdf-1 (via coiled coil domain); the interaction recruits mdf-1 to unattached kinetochores during mitosis and between homologous chromosomes in early anaphase of meiosis I (PubMed:24567362). May interact with bub-3; for localization at the kinetochore and the onset of anaphase (PubMed:24567362, PubMed:25987605).
messages: Nucleus
messages: Serine/threonine-protein kinase essential for spindle-assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores (PubMed:18936247, PubMed:19109417, PubMed:24567362, PubMed:25987605). mdf-1 recruitment is independent of bub-1 kinase activity (PubMed:24567362). Has a role in the correct kinetochore localization of the spindly-like protein spdl-1 (PubMed:18765790). In addition, during meiotic anaphase I, controls the recruitment of hcp-1/2 and klp-19 to the ring-shaped domain formed between chromosomes (PubMed:20729837). Involved in chromosome alignment, chromosome homolog segregation and spindle assembly (PubMed:20729837, PubMed:25987605). In association with bub-3 at the kinetochore region of chromosomes, promotes the onset on anaphase independently from spindle checkpoint signaling and promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Plays a role in nuclear envelope breakdown (PubMed:19109417). Required maternally during embryogenesis and in the zygote for the postembryonic development of several tissues including ventral cord neurons, gonad, intestine and seam cells (PubMed:19526056).
messages: cell cortex
messages: kinetochore

6239:CELE ZK40.1
gene id: 6239:CELE_ZK40.1
uniprot id: Q23087
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE Y47H10A.5
gene id: 6239:CELE_Y47H10A.5
uniprot id: Q9U2B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE Y55B1BM.1
gene id: 6239:CELE_Y55B1BM.1
uniprot id: G5EF60
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Coexpressed with orai-1 in spermatheca, gonad sheath cells and intestine. Also detected in neurons in the head and in the uterine epithelial cells. Heterogeneously expressed in the intestine with strong presence in the anterior and posterior intestine and weaker in the midsection.
messages: Homodimer. Interacts with orai-1.
messages: Membrane
messages: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis.
messages: Sterility due to dysfunction of somatic cells. Affects the store-operated Ca(2+) (SOC) activity.

6239:CELE F48E8.6
gene id: 6239:CELE_F48E8.6
uniprot id: Q09568
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cleaved by caspase ced-3 in vitro.
messages: Cytoplasm
messages: P-body
messages: RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including production of ectopic seam cells.

6239:CELE C06E7.6
gene id: 6239:CELE_C06E7.6
uniprot id: P54218
names: Function
messages: Required for spermiogenesis.

6239:CELE F01F1.10
gene id: 6239:CELE_F01F1.10
uniprot id: Q19089
uniprot id: Q8TA65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

6239:CELE Y32H12A.5
gene id: 6239:CELE_Y32H12A.5
uniprot id: Q9N536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE Y71H2AM.6
gene id: 6239:CELE_Y71H2AM.6
uniprot id: Q9BL36
names: Similarity
messages: Belongs to the PPC synthetase family.

6239:CELE K08E3.1
gene id: 6239:CELE_K08E3.1
uniprot id: Q9XUS8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T13B5.9
gene id: 6239:CELE_T13B5.9
uniprot id: Q965L2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE ZK270.2
gene id: 6239:CELE_ZK270.2
uniprot id: G5EBP4
uniprot id: G5EEG8
uniprot id: G5EEP9
uniprot id: G5EFD6
names: Subcellular Location Annotation
messages: adherens junction

6239:CELE T05C12.3
gene id: 6239:CELE_T05C12.3
uniprot id: Q22230
names: Function
names: Similarity
messages: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE T25B9.9
gene id: 6239:CELE_T25B9.9
uniprot id: Q17761
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

6239:CELE C52E4.6
gene id: 6239:CELE_C52E4.6
uniprot id: G5EBX3
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Involved in pre-mRNA splicing (By similarity). Functions in association with cyclin-dependent kinases (CDKs) (By similarity). Involved in induction of expression of heat shock protein hsp-16.2 in response to heat shock (PubMed:15611166). Plays a role in male tail development, perhaps acting together with cell cycle regulators cdc-25.2, cdk-1, cyb-3, and cyd-1 (PubMed:27923661).
messages: RNAi-mediated knockdown causes abnormal male tail morphology.

6239:CELE C04C3.3
gene id: 6239:CELE_C04C3.3
uniprot id: O44451
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Mitochondrion matrix
messages: Tetramer of 2 alpha and 2 beta subunits.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

6239:CELE K11G12.5
gene id: 6239:CELE_K11G12.5
uniprot id: G5EE96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:9733776). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, by supplying the substrates for the different metabolic processes (By similarity).
messages: Mitochondrion inner membrane

6239:CELE T06C12.7
gene id: 6239:CELE_T06C12.7
uniprot id: O45756
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T14B4.6
gene id: 6239:CELE_T14B4.6
uniprot id: P35799
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.

6239:CELE T10B5.5
gene id: 6239:CELE_T10B5.5
uniprot id: Q86S29
uniprot id: Q9TZS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE F11E6.1
gene id: 6239:CELE_F11E6.1
uniprot id: G5ECR8
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

6239:CELE K07B1.3
gene id: 6239:CELE_K07B1.3
uniprot id: O01883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE C02F5.6
gene id: 6239:CELE_C02F5.6
uniprot id: P34283
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily. HEN1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Broadly expressed in the germline and somatic tissues in both hermaphrodites and males.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in the germline and soma throughout development (at the protein level) (PubMed:22548001, PubMed:22829772). Highly expressed in embryos (PubMed:22548001, PubMed:22829772). Expression is lowest during the early larval stages and increases as the germline proliferates, peaking at the adult stage (PubMed:22548001).
messages: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways (PubMed:22536158, PubMed:22548001, PubMed:22829772). Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when they are bound by argonaute protein ergo-1 (PubMed:22536158, PubMed:22548001, PubMed:22829772). This occurs in the female germline and embryo, but not in the male germline (PubMed:22548001). Does not methylate 26G-siRNAs bound by argonaute proteins alg-3 or alg-4 (PubMed:22548001, PubMed:22829772). Methylates and stabilizes 21U-piRNAs, which are a class of 21 nucleotide piRNAs that possess a uracil residue at the 5'-end, in the male and female germline (PubMed:22536158, PubMed:22548001, PubMed:22829772). In addition, may play a role in exogenous RNAi (exoRNAi) pathways in the germline (PubMed:22829772).
messages: RNAi-mediated knockdown suppresses RNAi-mediated silencing by siR-1, which are 22G-siRNAs (a class of secondary 22 nucleotide siRNAs that possess a triphosphorylated guanine residue at the 5'-end and are formed from 21U-piRNAs and 26G-siRNAs).
messages: nucleoplasm

6239:CELE C27B7.8
gene id: 6239:CELE_C27B7.8
uniprot id: Q18246
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Required in the hypodermis for proper formation of the cuticle.
messages: Worms are viable and fertile but display molting defect. Longitudinal ridges termed alae, which are cuticular structures secreted by lateral hypodermal seam cells, are poorly distinct or interrupted. Died as a 'bag of worms' after degeneration of the proximal gonad, or alternatively, as a result of a burst vulva.

6239:CELE T21B4.17
gene id: 6239:CELE_T21B4.17
uniprot id: Q5FC44
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R04D3.7
gene id: 6239:CELE_R04D3.7
uniprot id: Q21715
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y46G5A.27
gene id: 6239:CELE_Y46G5A.27
uniprot id: P41991
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Pes-10 family.
messages: Cytoplasm
messages: Expressed in the somatic lineage from the 4-cell to 60-cell stage.
messages: In the embryo, expressed in newly arisen somatic blastomeres.
messages: Nucleus

6239:CELE ZK816.5
gene id: 6239:CELE_ZK816.5
uniprot id: Q23612
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE ZK938.2
gene id: 6239:CELE_ZK938.2
uniprot id: Q23672
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C47G2.1
gene id: 6239:CELE_C47G2.1
uniprot id: Q03755
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of the cuticles, which contributes to the formation of extracellular envelopes protecting the organism from the environment (PubMed:1864469) (Probable). Plays a role in alae formation in dauer larvae (PubMed:15936343, PubMed:30409788).
messages: Expressed in head and tail seam cells during dauer larva formation (PubMed:1864469, PubMed:15936343). In dauer phase larvae, expressed in two ribbons approximately 2 microns wide running along the lateral lines underneath the alae (PubMed:1864469). Not expressed in late embryogenesis or adults (PubMed:15936343).
messages: RNAi-mediated knockdown results in no alae in dauer stage larvae, which results in a wider lateral cuticle and larger body diameter.
messages: Secreted
messages: The small repeats A-A-P-[AVI] are also present in many proteins constituting the protective envelope of other species.

6239:CELE F08C6.2
gene id: 6239:CELE_F08C6.2
uniprot id: P49583
uniprot id: Q3HKC4
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE Y71G12B.10
gene id: 6239:CELE_Y71G12B.10
uniprot id: Q95XN1
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

6239:CELE F54H5.3
gene id: 6239:CELE_F54H5.3
uniprot id: P91330
names: Function
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T19D12.10
gene id: 6239:CELE_T19D12.10
uniprot id: O76838
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T06E6.2
gene id: 6239:CELE_T06E6.2
uniprot id: Q10654
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II (PubMed:20599902).
messages: Nucleus
messages: RNAi-mediated knockdown causes a longer meiosis II in 1-cell embryos without affecting meiotic exit timing. In a pam-1 (or282) mutant background, restores normal timing for meiotic exit.

6239:CELE T04C12.6
gene id: 6239:CELE_T04C12.6
uniprot id: P0DM41
uniprot id: P0DM42
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.
messages: cytoskeleton

6239:CELE C04E6.9
gene id: 6239:CELE_C04E6.9
uniprot id: O01466
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y26E6A.3
gene id: 6239:CELE_Y26E6A.3
uniprot id: Q7YWR7
names: Similarity
messages: Belongs to the UPF0585 family.

6239:CELE F23B12.8
gene id: 6239:CELE_F23B12.8
uniprot id: G5EGL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE F21A3.7
gene id: 6239:CELE_F21A3.7
uniprot id: G5EE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y38C1AA.2
gene id: 6239:CELE_Y38C1AA.2
uniprot id: Q9N425
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2 and csn-4. May interact with itself.
messages: Cytoplasm
messages: Nucleus

6239:CELE ZC302.1
gene id: 6239:CELE_ZC302.1
uniprot id: Q23255
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Forms a complex with rad-50.
messages: Involved in DNA double-strand break repair (DSBR) (PubMed:11238374). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11238374). Also involved in meiotic DSB processing (PubMed:11238374). In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).
messages: Nucleus
messages: RNAi-mediated knockdown results in DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites.
messages: Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.

6239:CELE H10D18.3
gene id: 6239:CELE_H10D18.3
uniprot id: Q9N5N5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y105C5B.28
gene id: 6239:CELE_Y105C5B.28
uniprot id: H8ESF5
uniprot id: Q2HQL4
uniprot id: Q9U307
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE F26E4.1
gene id: 6239:CELE_F26E4.1
uniprot id: G5EDR3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: Part of a complex consisting of a common heterodimeric core enzyme, composed of catalytic subunit let-92 and constant regulatory subunit paa-1, that associates with a variety of regulatory subunits which confer distinct properties to the holoenzyme (Probable). Interacts with let-92 (PubMed:21497766).
messages: Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1 (PubMed:21497766). In addition, during vulva development, may play a role with phosphatase let-92 and regulatory subunit paa-1 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation (PubMed:10521400, PubMed:14724126). In intestinal epithelial cells, may play a role in the late secretory pathway probably by regulating the exocyst, a protein complex involved in targeting secretory vesicles to the plasma membrane (PubMed:24192838).
messages: RNAi-mediated knockdown causes severe embryonic lethality (PubMed:10521400). In mutants, during the first embryonic divisions, P1 cell initiates division prior to AB cell, spindles appear abnormal or collapse during anaphase and chromatin bridges and supernumerary centrosomes are often detected (PubMed:14724126). In addition, RNAi-mediated knockdown causes a partial defect in centriole duplication during the first embryonic divisions where 24% of spindles are monopolar and 47% have asymmetric spindles, a decrease in the spindle protein sas-5 levels and occasional bridging of chromatin with no obvious defects in cell cycle progression or mitotic exit (PubMed:21497766). The few surviving animals of RNAi-mediated knockdown lack a vulva resulting from defects in vulva cell induction, vulva precursor cell (VPC) generation and in vulval execution lineage, and are slightly uncoordinated (PubMed:10521400). In L4 larvae mutants, somatic mpk-1/ERK phosphorylation is also severely reduced (PubMed:14724126). In intestinal epithelial cells, RNAi-mediated knockdown causes an accumulation of SNARE proteins including snb-1, snap-29 and syx-4 (PubMed:24192838). RNAi-mediated knockdown at the L1 larval stage in the exocyst component exoc-8 (ok2523) mutant background results in lethality (PubMed:24192838).

6239:CELE Y47D3B.11
gene id: 6239:CELE_Y47D3B.11
uniprot id: Q9U2B7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoubiquitinated.
messages: Belongs to the ZNRF3 family.
messages: Cell membrane
messages: Early endosome
messages: Expressed in a subset of head, ventral nerve cord and tail neurons, the excretory canal and tail epidermis.
messages: First expressed during the late gastrulation stage of embryogenesis with high expression in the tail region (PubMed:25448694). In the comma stage of embryogenesis, expression is prominent in the body wall muscle cells (PubMed:25448694). In early larval development, expressed in hypodermal cells, muscle, the pharynx, intestine and in anal depressor and stomatointestinal muscle (PubMed:25448694). In the nervous system, transiently expressed in late embryogenesis and early larval development in AVG unpaired interneurons and during larval development, expressed in neurons in the head and tail ganglia and ventral cord motor neurons (PubMed:24401370, PubMed:25448694). In the late stages of larval development, expressed in the distal tip cell, the vulva, uterine muscle cells and the VC4 and VC5 neurons that flank the vulva (PubMed:25448694).
messages: Late endosome
messages: Mutants exhibit cell migration and axon guidance defects in HSN, AVK, CAN and AVG neurons, and also display excretory canal elongation defects with premature termination of the canal. Double knockout with either unc-53 or vab-8 results in premature termination of the AVG axon and AVG polarity defects.
messages: Perikaryon
messages: Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
messages: The RING finger region is required to block Wnt signaling and is also required for endosomal localization.
messages: axon

6239:CELE T27E9.1
gene id: 6239:CELE_T27E9.1
uniprot id: O45865
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE F47B10.1
gene id: 6239:CELE_F47B10.1
uniprot id: P53588
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

6239:CELE F38E1.7
gene id: 6239:CELE_F38E1.7
uniprot id: Q10459
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Embryonic lethal with severely defective embryonic morphogenesis with the formation of unspecified differentiated tissues, no endoderm and excess mesoderm (PubMed:9288749). In addition, embryos have defective mitotic spindle orientation in the 8-cell stage ABar blastomere (PubMed:9288749, PubMed:16678095). RNAi-mediated knockdown results in irregular distribution of the mitotic spindle orientating factor sdn-1 and wnt signaling protein mig-5, with premature accumulation of sdn-1 on the cell surface of the ABar blastomere during the prophase stage of mitosis, and reduced accumulation of mig-5 at cell contact sites between the Abar and C blastomere cells, respectively (PubMed:25344071).
messages: Expressed by anchor cell and vulva precursor cell descendants P5.ppa, P5.ppp, P7.paa and P7.pap (PubMed:15369677). Expressed in the tail and weakly expressed in the vulva and body wall muscles (PubMed:20711352).
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288750, PubMed:9288749, PubMed:16678095, PubMed:25344071). Involved in cleavage axis determination (PubMed:9288750). Binds to receptor tyrosine kinase cam-1 (PubMed:17942487). Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18 (PubMed:15369677). May act redundantly with other Wnt ligands such as cwn-1 and cwn-2 to control seam cell polarity (PubMed:22022276).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE Y71F9AR.1
gene id: 6239:CELE_Y71F9AR.1
uniprot id: G5ECL4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Cell membrane
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in head and tail neurons, the ventral nerve cord, the VulF vulval cell and in the somatic gonad (PubMed:14551437). Expressed in the male-specific sensory neuron HOA (PubMed:28901288).
messages: Interacts with casy-1; the interaction establishes synaptic connections between neurons.
messages: Maintains the normal guidance and termination of axonal branches of VC motorneurons (PubMed:14551437). By associating with cell adhesion protein casy-1, mediates axonal interactions to establish synaptic connections between the male-specific sensory neuron HOA and the AVG interneuron (PubMed:28901288). Plays a role in regulating male mating behavior (PubMed:28901288).
messages: axon

6239:CELE F35H12.3
gene id: 6239:CELE_F35H12.3
uniprot id: P52166
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Ubiquitously expressed throughout the development and in the adult.
messages: Expressed in most neurons.
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable). Interacts with sel-10 (PubMed:9861048).
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling (PubMed:27661254).
messages: The PAL motif is required for normal active site conformation.

6239:CELE B0393.1
gene id: 6239:CELE_B0393.1
uniprot id: P46769
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps-21.
messages: Cytoplasm
messages: Expressed at a stable level throughout development.
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Involved in cold-warm shock-induced translocation of the RNA exosome components from the nucleolus to nucleoplasm (PubMed:36763670).

6239:CELE D1043.1
gene id: 6239:CELE_D1043.1
uniprot id: G5EDW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

6239:CELE F26D11.11
gene id: 6239:CELE_F26D11.11
uniprot id: O61967
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the LAP (LRR and PDZ) protein family.
messages: Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization (PubMed:18411252). With dlg-1, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019).
messages: Expressed in all embryonic epithelial cells.
messages: Expressed in the terminal web of the intestine (PubMed:15063180, PubMed:27506200). Expressed in seam cells (PubMed:27506200).
messages: Worms display a severely affected epithelial integrity, leading to abnormal morphogenesis of the pharynx, intestine and embryo.

6239:CELE ZK1290.12
gene id: 6239:CELE_ZK1290.12
uniprot id: Q94128
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE Y41C4A.14
gene id: 6239:CELE_Y41C4A.14
uniprot id: G5EC44
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rad1 family.
messages: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:12445383, PubMed:16951081). Promotes DNA double strand break-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability (PubMed:10882129, PubMed:10646593, PubMed:16951081). Also required for telomere length maintenance and germline immortality (PubMed:10646593, PubMed:16951081, PubMed:22547822). May possess 3'->5' double stranded DNA exonuclease activity (By similarity).
messages: Nucleus
messages: Probable component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of hpr-9, mrt-2 and hus-1 (PubMed:12445383). Interacts with hus-1 (PubMed:12445383). Might associate with hpr-9 (Probable).
messages: RNAi-mediated knockdown disrupts hus-1 localization to the nucleus.

6239:CELE F09C12.2
gene id: 6239:CELE_F09C12.2
uniprot id: Q19243
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

6239:CELE F20G2.1
gene id: 6239:CELE_F20G2.1
uniprot id: Q93544
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE Y76A2A.2
gene id: 6239:CELE_Y76A2A.2
uniprot id: G5ED40
uniprot id: G5EE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

6239:CELE ZC395.10
gene id: 6239:CELE_ZC395.10
uniprot id: Q23280
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the p23/wos2 family.
messages: Co-chaperone for hsp90/daf-21 (PubMed:20880838). Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures (PubMed:25830239).
messages: Expressed from embryo to adulthood.
messages: Expressed in anterior and posterior neurons including ASE, AWC, ASI and ADL amphids and phasmid sensory neurons, peripheral neurons and ventral cord motorneurons. Additionally expressed in body wall muscle, pharynx, vulva, germ cells and intestine.
messages: Resistant to oxidative and heat stress. At increased temperatures, there is increased longevity and an increased propensity of larvae to form dauer. At decreased temperatures, lifespan is shorter. Defective chemotaxis in response to toxins.

6239:CELE R06F6.6
gene id: 6239:CELE_R06F6.6
uniprot id: Q09602
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C04E6.12
gene id: 6239:CELE_C04E6.12
uniprot id: A0A1N7SYR9
uniprot id: A0A1N7SYS1
uniprot id: A0A1N7SYS4
uniprot id: A0A1N7SYU3
names: Subcellular Location Annotation
messages: Secreted

6239:CELE W07B8.1
gene id: 6239:CELE_W07B8.1
uniprot id: O16289
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C34F6.7
gene id: 6239:CELE_C34F6.7
uniprot id: O17638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

6239:CELE K07H8.6
gene id: 6239:CELE_K07H8.6
uniprot id: P18948
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance (PubMed:24957743).
messages: RNAi-mediated knockdown causes a reduction in the uptake of cholesterol analog dehydroergosterol (DHE). Simultaneous RNAi-mediated knockdown of zmp-2 prevents a reduction in survival upon heat stress.
messages: Secreted
messages: Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

6239:CELE C30C11.1
gene id: 6239:CELE_C30C11.1
uniprot id: Q04907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Mitochondrion

6239:CELE W02G9.2
gene id: 6239:CELE_W02G9.2
uniprot id: G5ED84
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the BCR(kel-8) E3 ubiquitin ligase complex, at least composed of cul-3, kel-8 and rbx-1. Interacts with rpy-1.
messages: Expressed in neurons.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1.
messages: Synapse

6239:CELE T27F2.1
gene id: 6239:CELE_T27F2.1
uniprot id: Q22836
names: Similarity
messages: Belongs to the SNW family.

6239:CELE C34H4.4
gene id: 6239:CELE_C34H4.4
uniprot id: Q86S35
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C06G3.10
gene id: 6239:CELE_C06G3.10
uniprot id: Q21444
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG2 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi morphology and function.

6239:CELE H20J04.5
gene id: 6239:CELE_H20J04.5
uniprot id: Q9N5M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE Y50D7A.13
gene id: 6239:CELE_Y50D7A.13
uniprot id: A0A0K3ARD1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

6239:CELE T09E11.1
gene id: 6239:CELE_T09E11.1
uniprot id: O02304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y105C5B.25
gene id: 6239:CELE_Y105C5B.25
uniprot id: A0A078BTR2
uniprot id: Q9NAL8
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F33H2.1
gene id: 6239:CELE_F33H2.1
uniprot id: O62217
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K10B2.5
gene id: 6239:CELE_K10B2.5
uniprot id: Q09994
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Enriched in adults.
messages: Localizes to the surface of the rachis.
messages: Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis.

6239:CELE Y69A2AR.7
gene id: 6239:CELE_Y69A2AR.7
uniprot id: H2L0S0
uniprot id: Q86DD3
uniprot id: Q95XH2
names: Similarity
messages: Belongs to the ATG101 family.

6239:CELE T06H11.4
gene id: 6239:CELE_T06H11.4
uniprot id: G5EGH2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

6239:CELE T01E8.4
gene id: 6239:CELE_T01E8.4
uniprot id: Q22071
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in several neurons in the head, tail and ventral cord, but absent in touch receptor neurons in adults (PubMed:19652181, PubMed:23527112). Expressed in GABAergic and cholinergic motor neurons (PubMed:23527112).
messages: Expressed in touch receptor neurons and several neurons in the head, tail and ventral cord during larval development.
messages: May interact with the SCF ubiquitin ligase complex component skr-1.
messages: Perikaryon
messages: Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation (PubMed:8692859, PubMed:19652181). Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons (PubMed:23527112).
messages: Temperature-sensitive phenotype with defective touch receptor neuron synaptic transmission conferring variable degrees of touch insensitivity amongst individual animals (PubMed:8692859, PubMed:19652181). Touch receptor neurons and GABAergic motor neurons have mis-localized presynaptic vesicles as indicated by aberrant expression of the protein snb-1 and distorted cell bodies (PubMed:19652181, PubMed:23527112). Reduced rate of inhibitory postsynaptic currents at the neuromuscular junctions of GABAergic motor neurons (PubMed:23527112). No effects on cholinergic synaptic transmission or snb-1 distribution in cholinergic motor neurons (PubMed:23527112). Increased rate of paralysis, in response to acetylcholine esterase inhibition by the drug Aldicarb, due to increased accumulation of acetylcholine in the extracellular fluid resulting permanent contraction of body wall muscles (PubMed:23527112). Knockout with a mec-7 heterozygous mutant, but not a null mec-7 mutant, rescues the touch sensitivity defect in the mec-15 single mutant (PubMed:19652181).

6239:CELE Y45F3A.9
gene id: 6239:CELE_Y45F3A.9
uniprot id: Q9XWY8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

6239:CELE F33H2.5
gene id: 6239:CELE_F33H2.5
uniprot id: O62218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

6239:CELE T18D3.9
gene id: 6239:CELE_T18D3.9
uniprot id: Q7YWV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Involved in mitochondria homeostasis.
messages: Mitochondrion inner membrane

6239:CELE B0035.4
gene id: 6239:CELE_B0035.4
uniprot id: Q17435
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE C02F5.7
gene id: 6239:CELE_C02F5.7
uniprot id: P34284
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
messages: Expressed in neuroglial cells such as the socket cell and sheath cell, neurosecretory motor neurons and regions around the pharynx and anus.
messages: Perikaryon
messages: RNAi-mediated knockdown reduces the rate of dauer formation following treatment with daumone, a pheromone which induces the dauer state (Ref.3, PubMed:30460068). RNAi-mediated knockdown results in a 10-20% increase in the average time interval between defecations in hermaphrodites (Ref.3, PubMed:30460068).
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state (Ref.3, PubMed:30460068). In hermaphrodites, may play a role in modulating the rate of defecation (Ref.3, PubMed:30460068).
messages: axon
messages: cilium
messages: dendrite

6239:CELE C34E10.5
gene id: 6239:CELE_C34E10.5
uniprot id: P46580
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1 (PubMed:19521535, PubMed:21531333, PubMed:23866019, PubMed:22143770, PubMed:28158808). Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group (PubMed:23866019). Plays a role in the negative regulation of DNA damage-induced apoptosis (PubMed:19521535). By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535). Plays a role in heat and oxidative stress resistance (PubMed:28158808).
messages: Defective arginine methyltransferase activity with reduced symmetric dimethylation of targets (PubMed:28158808). Increased sensitivity to heat and oxidative stress (PubMed:28158808). Increased germ cell apoptosis following treatment with ionizing radiation (IR) or ethylnitrosourea and significantly enhanced IR-induced egl-1 levels (PubMed:19521535). Double knockout with prmt-1 results in prolonged larval development, shorter body size, reduced brood size, decreased egg-laying and 30% of eggs fail to hatch (PubMed:28158808). Double knockout also results in reduced asymmetric and symmetric arginine dimethylation of proteins (PubMed:28158808).
messages: Homodimer (PubMed:22143770). Interacts with cep-1 (via C-terminus domain); does not methylate cep-1 (PubMed:19521535). Interacts with cbp-1 (via N-terminus domain and HAT domain); the interaction results in methylation of cbp-1 (PubMed:19521535). Component of a complex that contains cep-1 and cbp-1 (PubMed:19521535). May interact with pid-2, pid-4 and pid-5 (PubMed:33231880).
messages: Nucleus

6239:CELE Y51A2D.8
gene id: 6239:CELE_Y51A2D.8
uniprot id: Q9XXQ7
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE K02F2.3
gene id: 6239:CELE_K02F2.3
uniprot id: O44985
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F10E7.9
gene id: 6239:CELE_F10E7.9
uniprot id: Q19301
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C26E6.6
gene id: 6239:CELE_C26E6.6
uniprot id: P49404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Mitochondrion

6239:CELE T20F5.3
gene id: 6239:CELE_T20F5.3
uniprot id: P91478
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Mitochondrion
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

6239:CELE F53F4.5
gene id: 6239:CELE_F53F4.5
uniprot id: G5EDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE F28H7.7
gene id: 6239:CELE_F28H7.7
uniprot id: Q19894
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE T13H5.6
gene id: 6239:CELE_T13H5.6
uniprot id: Q9U369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

6239:CELE T23B12.4
gene id: 6239:CELE_T23B12.4
uniprot id: O17003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

6239:CELE C41G6.3
gene id: 6239:CELE_C41G6.3
uniprot id: O17656
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C39B5.11
gene id: 6239:CELE_C39B5.11
uniprot id: Q9N5W4
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE R07B5.9
gene id: 6239:CELE_R07B5.9
uniprot id: K8ERR8
names: Function
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Probable histone acetyltransferase (Probable). Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons (PubMed:20923973). Involved in determining cell fate in the ASE neurons (PubMed:20923973).

6239:CELE F20D1.6
gene id: 6239:CELE_F20D1.6
uniprot id: Q93538
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.

6239:CELE F14A5.1
gene id: 6239:CELE_F14A5.1
uniprot id: Q19438
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK652.5
gene id: 6239:CELE_ZK652.5
uniprot id: P34663
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus
messages: Probable transcription factor (PubMed:11493519). Required for differentiation of AIY interneurons, acting downstream of LIM/homeobox protein ttx-3 (PubMed:11493519). Modulates gene expression, acting downstream of AMP kinase aak-2/AMPK signaling (PubMed:28560849). Modulates lifespan (PubMed:28560849, PubMed:21713031).
messages: Viable and display no obvious neuroanatomical, morphological or locomotory abnormalities (PubMed:11493519). Lifespan reduced in an isp-1 or nuo-6 mutant background and extends lifespan in the short-lived gas-1 and mev-1 mutants (PubMed:28560849, PubMed:21713031). Expression of the G protein-coupled receptor sra-11 is normal in AIY neurons at the larval L1 stage, but drastically reduced in adults (PubMed:11493519). RNAi-mediated knockdown reduces lifespan in various mitochondrial mutant backgrounds, including isp-1;ctb-1, or clk-1 (PubMed:21713031).

6239:CELE C10H11.9
gene id: 6239:CELE_C10H11.9
uniprot id: P92199
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by rho-1 binding.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Expressed in the lateral hypodermal seam cells at the onset of the elongation phase of morphogenesis (at protein level).
messages: Interacts with rho-1.
messages: Loss of both zygotic and maternal expression causes defects in embryonic elongation and P-cell migration, loss of only maternal expression results in abnormal early cleavages, loss of only zygotic expression results in sterility.
messages: Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
messages: cytoskeleton

6239:CELE F44E2.10
gene id: 6239:CELE_F44E2.10
uniprot id: Q95QG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F25B5.5
gene id: 6239:CELE_F25B5.5
uniprot id: Q09316
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Potential regulator of CDK5 activity.

6239:CELE Y70C5C.6
gene id: 6239:CELE_Y70C5C.6
uniprot id: O62496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F29C4.6
gene id: 6239:CELE_F29C4.6
uniprot id: O76365
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Required for normal germline maturation and for viability. Viable at 20 degrees Celsius. At a higher temperature (25 degrees Celsius), the hatched eggs progress through the L1-L4 larval stages with kinetics similar to those of wild type but present an important delay in germline maturation. Whereas gravid wild-type worms are present 53 hours after hatching, germline maturation are still ongoing in the mutant after 66 hours, and the first adults containing eggs are observed 75 hours after hatching, when a large number of new L1 are already present in the wild type. Strikingly, the eggs that finally appeared in the mutant display aberrant morphology and size resulting in both low progeny and high mortality.

6239:CELE Y43H11AL.2
gene id: 6239:CELE_Y43H11AL.2
uniprot id: A0A0K3ARR4
uniprot id: Q95XZ6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes (PubMed:22822152). May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function (PubMed:25124690).
messages: Belongs to the laat-1 family.
messages: Lysosome membrane
messages: Membrane
messages: Mutants are viable but develop slowly. They accumulate enlarged lysosomes and show an impaired lysosomal degradation of phagocytic, endocytic, and autophagic cargos.
messages: The di-leucine motif mediates lysosomal localization.

6239:CELE ZK970.5
gene id: 6239:CELE_ZK970.5
uniprot id: Q23681
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expression is biased toward ASE right (ASER) sensory neuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Br(1-) and I(1-) salt ions in ASE right (ASER) sensory neuron (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE Y105E8B.8
gene id: 6239:CELE_Y105E8B.8
uniprot id: V6CLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

6239:CELE C15H9.8
gene id: 6239:CELE_C15H9.8
uniprot id: Q18028
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

6239:CELE ZC373.6
gene id: 6239:CELE_ZC373.6
uniprot id: Q23262
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the seam cells, and in the hyp7 syncytial hypodermis in the mid-L4 larval stage (PubMed:24569038). Not expressed in the cells of the developing vulva (PubMed:24569038).
messages: Nucleus
messages: Probably acts downstream of the Wnt signaling pathway.
messages: RNAi-mediated knockdown causes dumpy body shape (PubMed:24569038). Defects in cuticle integrity (PubMed:24569038).
messages: Secreted

6239:KEF34 p12
gene id: 6239:KEF34_p12
uniprot id: P24885
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

6239:CELE C35D10.2
gene id: 6239:CELE_C35D10.2
uniprot id: Q18488
names: Similarity
messages: Belongs to the GIPC family.

6239:CELE F46C5.4
gene id: 6239:CELE_F46C5.4
uniprot id: P52882
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T27F7.1
gene id: 6239:CELE_T27F7.1
uniprot id: Q9GYK4
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE C28A5.3
gene id: 6239:CELE_C28A5.3
uniprot id: Q27473
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6239:CELE E02A10.1
gene id: 6239:CELE_E02A10.1
uniprot id: Q93425
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE T22G5.6
gene id: 6239:CELE_T22G5.6
uniprot id: O02324
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Intestine.
messages: Lysosomal lipid chaperone which binds to a wide range of unsaturated fatty acids, including high affinity binding to oleic acid and oleoylethanolamide, to transport them into the nucleus (PubMed:31292465, PubMed:25554789). As part of a lysosome-to-nucleus retrograde lipid signaling pathway, translocates into the nucleus where it activates the transcription of genes promoting longevity and activation of mitochondrial beta oxidation (PubMed:30713071, PubMed:25554789).
messages: Lysosome
messages: Monomer.
messages: Nucleus

6239:CELE Y116A8C.18
gene id: 6239:CELE_Y116A8C.18
uniprot id: Q9U2V3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C47B2.4
gene id: 6239:CELE_C47B2.4
uniprot id: O62102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

6239:CELE K02C4.4
gene id: 6239:CELE_K02C4.4
uniprot id: G5EF51
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the transglutaminase-like superfamily.
messages: Cytoskeleton-associated protein (Probable). May play a role in hypodermal cell development (Probable).
messages: Expressed in the Y and U rectal epithelial cells, in marginal cells of the terminal bulb and isthmus of the pharynx (at protein level).
messages: Expressed throughout development (at protein level). First expressed in two-fold stage embryos (at protein level) (PubMed:12204272). During embryogenesis, expressed in the apical regions of the dorsal and ventral hypodermis in tightly organized circumferential filament bundles (at protein level) (PubMed:12204272). Expressed in seam cells in embryos and at the larval stages (at protein level) (PubMed:12204272). In L1 stage larvae, expressed in the apical junction between hypodermal cells hyp 5, hyp 6 and hyp 7, and between the seam cells and the P blast cells in the ventral midline (at protein level) (PubMed:12204272). In L2 stage larvae, expressed in the Y and U rectal epithelial cells (at protein level) (PubMed:12204272). In L3 stage larvae, expressed in the pharynx, socket cells, the processes that link socket cells to the amphid, in marginal cells of the terminal bulb and at the junction between the pharynx lumen and the hypodermis (at protein level) (PubMed:12204272). In L4 stage larvae, expressed in longitudinal filaments within the cytoplasm linking both extremities of the elongating seam cells and in the alae formed by their fusion (at protein level) (PubMed:12204272).
messages: Unlike the mammalian homolog KY, the residues forming the catalytic triad in the putative transglutaminase-like domain of ltd-1 are not conserved, therefore it is likely that the protein lacks protease activity.
messages: cytoskeleton

6239:CELE C36B1.4
gene id: 6239:CELE_C36B1.4
uniprot id: Q95005
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

6239:CELE R04B5.4
gene id: 6239:CELE_R04B5.4
uniprot id: A5JYT1
uniprot id: I2HAH0
uniprot id: Q21701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y46E12A.4
gene id: 6239:CELE_Y46E12A.4
uniprot id: Q1T6W8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

6239:CELE F46F3.4
gene id: 6239:CELE_F46F3.4
uniprot id: Q9XVN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iASPP family.
messages: Interacts with cep-1/p53; the interaction inhibits pro-apoptotic activity of cep-1.
messages: Negetively regulates apoptosis via its interaction with cep-1.
messages: Nucleus
messages: RNAi-mediated knockdown results in an increase in number of apoptotic germ cells (PubMed:12524540). Double RNAi-mediated knockdown together with cep-1 abrogates this increased number of apoptotic germ cells (PubMed:12524540).

6239:CELE R09G11.1
gene id: 6239:CELE_R09G11.1
uniprot id: Q17374
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Gain of function uncoordinated rubber band response is phenocopied by exposure to the unc-49 agonist muscimol.
messages: Low levels in body-wall muscles, eight vulval muscles, intestinal muscles and anal depressor muscle.
messages: May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex.
messages: May form a complex with sup-9 and unc-93 where sup-10 and unc-93 act as regulatory subunits of the two pore potassium channel sup-9. Sup-10 may regulate sup-9 via sup-18.
messages: Membrane

6239:CELE T15H9.6
gene id: 6239:CELE_T15H9.6
uniprot id: Q09995
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

6239:CELE F20D6.3
gene id: 6239:CELE_F20D6.3
uniprot id: Q19651
names: Similarity
messages: Belongs to the serpin family.

6239:CELE T19B10.8
gene id: 6239:CELE_T19B10.8
uniprot id: Q22561
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

6239:CELE B0228.5
gene id: 6239:CELE_B0228.5
uniprot id: Q09433
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the thioredoxin family.
messages: Expressed in ASJ and ASI ciliated sensory neurons (PubMed:16387300, PubMed:21304598, PubMed:16324156, PubMed:21334311). Expressed in the intestine (at protein level) (PubMed:16324156).
messages: Expressed in larval stages L2 and L3 and increased expression during dauer stage (PubMed:21304598). Expressed in adult animals with increased expression in 10-day-old animals (PubMed:16324156).
messages: Increased nitric oxide-evoked calcium flux to cytoplasm in ASJ sensory neurons (PubMed:30014846). Decreased avoidance of P.aeruginosa (PubMed:30014846). Decrease in lifespan (PubMed:16387300, PubMed:16324156). Suppression of lifespan extension induced by dietary deprivation or in an eat-2(ad1116) mutant background and partial suppression in a daf-2(e1370) mutant background (PubMed:21334311). Enhancement of the constitutive dauer formation phenotype in a daf-11(ks67), daf-11(m47), daf-11(sa195), daf-7(e1372), daf-1(e1287) or daf-8(e1393) mutant background at 15 degrees Celsius (PubMed:21304598). Suppression of the constitutive dauer formation phenotype in a daf-11(sa195), daf-28(tm2308) or daf-28(sa191) mutant background at 25 degrees Celsius (PubMed:21304598). Failure in down-regulation of daf-28 expression during dauer stage (PubMed:21304598). Decreased survival when facing oxidative stress upon exposure to sodium arsenite or paraquat (PubMed:26920757, PubMed:16324156). Increased localization of skn-1 to the nuclei of intestinal cells (PubMed:26920757). Suppression of skn-1 nuclear localization in a nsy-1(ok593), sek-1(km4) or pmk-1(km25) mutant background (PubMed:26920757).
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:16324156, PubMed:16387300). Shown to facilitate the reduction of insulin disulfide bonds (PubMed:16324156, PubMed:16387300). Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide (PubMed:30014846). Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to a NO stimulus, whereas de-nitrosylation activity might promote calcium flux when NO is diminished (PubMed:30014846). By regulating the NO-induced ASJ sensory neuron activity, mediates the avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846). Positively regulates life span extension under normal and caloric restriction conditions, dauer formation and the oxidative stress response (PubMed:16387300, PubMed:16324156, PubMed:21334311, PubMed:21304598, PubMed:26920757). Contributes to the down-regulation of expression of the insulin-like neuropeptide daf-28 in the ASJ neurons in a redox-independent fashion, thereby promoting dauer formation (PubMed:21304598). Negatively regulates the nuclear localization of the intestinal skn-1 transcription factor in a p38 MAPK pathway-dependent and redox-independent fashion (PubMed:26920757).
messages: Up-regulated in response to dietary restriction and during dauer formation.

6239:CELE ZK1127.1
gene id: 6239:CELE_ZK1127.1
uniprot id: Q23406
names: Similarity
messages: Belongs to the nanos family.

6239:CELE Y57G11C.2
gene id: 6239:CELE_Y57G11C.2
uniprot id: O18228
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F38H4.6
gene id: 6239:CELE_F38H4.6
uniprot id: Q20185
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZC376.4
gene id: 6239:CELE_ZC376.4
uniprot id: Q23269
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C16B8.1
gene id: 6239:CELE_C16B8.1
uniprot id: G5EGT9
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed in vulva cell precursors (VPC) P5.p, P6.p and P7.p, and their descendants during L3 and L4 larval stages.
messages: Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development (PubMed:15369677, PubMed:15649465). Regulates pop-1 asymmetric distribution in P7.p and its daughter cells (PubMed:15649465). Plays a role in the migration of ALM neurons during embryogenesis (PubMed:18622031).
messages: May lack kinase activity. The human ortholog has been shown to have impaired catalytic activity with an inability to undergo autophosphorylation or to phosphorylate substrates.

6239:CELE F15D4.1
gene id: 6239:CELE_F15D4.1
uniprot id: G5EF07
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y46H3D.8
gene id: 6239:CELE_Y46H3D.8
uniprot id: Q966B6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0228.4
gene id: 6239:CELE_B0228.4
uniprot id: Q09221
names: Similarity
names: Tissue Specificity
messages: Belongs to the copine family.
messages: Expressed in body wall muscle.

6239:CELE Y50D4B.4
gene id: 6239:CELE_Y50D4B.4
uniprot id: A0A0K3ASH9
uniprot id: A0A0K3ASI0
uniprot id: A0A0K3AT32
uniprot id: A0A0K3AVD4
uniprot id: A0A0K3AW37
uniprot id: A0A0K3AYC5
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE K04C2.4
gene id: 6239:CELE_K04C2.4
uniprot id: Q21209
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated.
messages: Chromosome
messages: Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity (PubMed:16628214). When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase (PubMed:16628214). Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites (PubMed:16628214). To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:14711411, PubMed:30383754). Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation for example (PubMed:14711411, PubMed:30383754). In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability (PubMed:14711411).
messages: Cytoplasm
messages: DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites (PubMed:16628214). RNAi-mediated knockdown results in elevated levels of chromosome non-disjunction that manifest as a high incidence of males, impaired progeny survival and chromosome fragmentation after irradiation and elevated levels of p53-dependent germ cell death before and after irradiation (PubMed:14711411). Absence of S-phase checkpoint function.
messages: E3 ubiquitin-protein ligase activity of CeBCD complexes occurs at DNA damage sites. Following DNA damage, E3 ubiquitin-protein ligase activity is reduced by caffeine treatment (inhibitor of ATM and ATK kinase activity).
messages: Heterodimer (via RING-type zinc finger) with brc-1 to form the core CeBCD complex (PubMed:16628214). Brc-1-brd-1 heterodimer-containing CeBCD complexes bound to chromatin are activated as an E3-ubiquitin ligase in response to DNA damage (PubMed:16628214). The heterodimer interacts with the recombinase rad-51 following ionizing irradiation; the interaction is direct (PubMed:16628214). The heterodimer interacts the E2-ubiquitin-conjugating enzyme let-70 following ionizing irradiation (PubMed:16628214). The heterodimer interacts with the pro-crossover proteins msh-5 and syp-3 (PubMed:30383754). Interacts with smt-3, tac-1 and ubc-9 (PubMed:14711411).
messages: Nucleus
messages: Phosphorylation of CeBCD complexes is required for E3 ubiquitin-protein ligase activity.

6239:CELE C16A3.9
gene id: 6239:CELE_C16A3.9
uniprot id: P51404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

6239:CELE F40F12.5
gene id: 6239:CELE_F40F12.5
uniprot id: H2L265
uniprot id: H2L266
uniprot id: Q7JMS4
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

6239:CELE B0041.4
gene id: 6239:CELE_B0041.4
uniprot id: O02056
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

6239:CELE Y53C12B.5
gene id: 6239:CELE_Y53C12B.5
uniprot id: O18214
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in late larvae of both sexes. In the fourth larval stage, expression is approximately six-fold higher in males than in hermaphrodites. Expressed in ADF chemosensory neurons in males from the L4 larval stage (PubMed:31264582). Expressed in cells of the male tail tip from the L4 larval stage (PubMed:18550714). Not expressed in cells of the hermaphrodite tail tip at any developmental stage (PubMed:18550714).
messages: Expression is undetectable in hermaphrodites, but persists in males (PubMed:9490411). In males, expressed in cells of the tail tip (PubMed:18550714).
messages: Negatively regulated by lin-41 which causes degradation of the mRNA encoding this protein.
messages: Nucleus
messages: Transcription factor which binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer (PubMed:9490411). Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis (PubMed:18550714, PubMed:21408209). Promotes male-specific development of two tissues, the peripheral nervous system and the intestine (PubMed:9490411). In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs (PubMed:9490411). In the intestine, causes repression of vitellogenin gene transcription (PubMed:9490411).

6239:CELE F07A11.3
gene id: 6239:CELE_F07A11.3
uniprot id: Q19131
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Highly expressed in embryos (at protein level) (PubMed:19167330, PubMed:22238360). Expression decreases rapidly in larvae and becomes restricted to the germline in adults (PubMed:19167330).
messages: Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air-2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import.
messages: Larval lethality with about 9-12 percent of animals reaching adulthood. The few surviving adults are sterile. About 10 percent embryonic lethality. Reduced nuclear growth in P1 embryonic cell and delayed entry into mitosis. 39 percent reduction in him-10 kinetochore association and 34 percent reduction in air-2 chromatin association during metaphase. Loss of npp-5 localization to kinetochores during metaphase. About 10 percent of mutants have chromosome segregation defects. RNAi-mediated knockdown causes a loss of npp-23 localization to kinetochores and reduced localization to the nuclear envelope in interphase. Also results in the accumulation of spindle assembly checkpoint protein mdf-1 on kinetochores during metaphase and reduced mdf-1 localization to the nuclear envelope. Does not affect the expression levels of nuclear pore complex components npp-10, npp-19 and npp-7 or npp-10, npp-2 and mel-28 localization and appears to be dispensable for pie-1 nuclear import and for nuclear protein exclusion. Embryos transiently exposed to a hypoxic environment develop into infertile adults. Simultaneous RNAi-mediated knockdown of mdf-1 causes embryonic lethality and severe chromosome segregation defects.
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC) (By similarity). May interact with mdf-1 (PubMed:22238360).
messages: kinetochore
messages: nuclear pore complex

6239:CELE F54E7.7
gene id: 6239:CELE_F54E7.7
uniprot id: P53806
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the RCAN family.
messages: Expressed from late embryogenesis to adulthood.
messages: Expressed in lateral hypodermal cells, marginal cells of the pharynx, vulva epithelial cells, ventral and dorsal nerve cords and commissures and various neurons in the anterior and posterior regions (PubMed:12684004, PubMed:27871170). Expressed in male tail structures including the diagonal muscles, sensory rays and spicules (PubMed:12684004, PubMed:27871170). Expressed in PHC neurons and most tail neurons and support cells of the phasmid neurons (PubMed:21408209). Also expressed in pharyngeal muscle, head neurons, excretory canal cells and hypodermal seam cells (PubMed:27871170).
messages: Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions (PubMed:12684004, PubMed:26232604, PubMed:27871170). Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons (PubMed:26232604). In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1 (PubMed:26232604). May play a role in regulating body size (PubMed:27871170). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Interacts with tax-6 (via catalytic domain); the interaction is calcium-dependent.
messages: Slightly shorter body length as compared to wild-type (PubMed:27871170). Reduced calcium responses in AFD neurons upon a temperature increase from 16 to 20 degrees Celsius as compared to wild-type (PubMed:26232604). At 17 and 20 degrees Celsius displays cryophilic behavior, preferentially migrating towards colder regions (PubMed:26232604). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209).

6239:CELE C03B8.3
gene id: 6239:CELE_C03B8.3
uniprot id: Q11106
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K04F10.7
gene id: 6239:CELE_K04F10.7
uniprot id: O44772
names: Similarity
messages: Belongs to the FAM76 family.

6239:CELE C49A9.8
gene id: 6239:CELE_C49A9.8
uniprot id: O44149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE K04F1.15
gene id: 6239:CELE_K04F1.15
uniprot id: Q9TXM0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE F21F8.11
gene id: 6239:CELE_F21F8.11
uniprot id: O01537
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C15C7.5
gene id: 6239:CELE_C15C7.5
uniprot id: Q18012
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell junction
messages: Dynamic component of the endotube in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.
messages: Expressed in many epithelial tissues, including the pharynx, intestine, excretory canal and hypodermis.
messages: First apparent at the comma stage of embryonic development, at the apical domain of intestinal cells. In subsequent embryonic stages, becomes visible in the hypodermis and pharynx. In larval and adult stages, detected in many epithelial tissues, including the pharynx, intestine, excretory canal and hypodermis.
messages: Mutants are viable but developmentally delayed. They have bubble-shaped invaginations of the apical membrane into the cytoplasm of intestinal cells and abnormal aggregations of the subapical intermediate filament (IF) network.
messages: cytoskeleton

6239:CELE T09A12.2
gene id: 6239:CELE_T09A12.2
uniprot id: H2KYJ6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE H17B01.1
gene id: 6239:CELE_H17B01.1
uniprot id: O44827
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Facilitative glucose transporter that plays a role in glucose metabolism and regulation of longevity. May also play a role in lipid metabolism. Glucose transport activity of isoform a is competitively inhibited by mannose, galactose and fructose, suggesting ability to transport also other hexose sugars.
messages: Isoform a is expressed in pharyngeal muscle and intestinal cells in both embryos and adults (at protein level).
messages: RNAi-mediated knockdown of the protein causes reduced 2-deoxy-D-glucose uptake, glucose oxidation and glucose conversion to triglyceride; simultaneous knockout of daf-2 or age-1 causes further reductions. The lifespan in low glucose environment is extended by 20-25% after knockdown, with 7% extension in daf-2 mutant background and no significant extension in age-1 mutant background. Fat accumulation in intestinal cells is increased. Brood size and dauer formation are not affected.

6239:CELE F42A6.9
gene id: 6239:CELE_F42A6.9
uniprot id: O44490
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE D1005.1
gene id: 6239:CELE_D1005.1
uniprot id: P53585
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
messages: Cytoplasm
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

6239:CELE K07A3.1
gene id: 6239:CELE_K07A3.1
uniprot id: G5EBJ7
names: Similarity
messages: Belongs to the FBPase class 1 family.

6239:CELE C42D8.4
gene id: 6239:CELE_C42D8.4
uniprot id: I7KSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

6239:CELE F54C9.5
gene id: 6239:CELE_F54C9.5
uniprot id: P49405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

6239:CELE F59A7.9
gene id: 6239:CELE_F59A7.9
uniprot id: O16284
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

6239:CELE T28H11.6
gene id: 6239:CELE_T28H11.6
uniprot id: Q23058
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE K06C4.13
gene id: 6239:CELE_K06C4.13
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE C05C8.2
gene id: 6239:CELE_C05C8.2
uniprot id: O16311
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

6239:CELE C15H7.3
gene id: 6239:CELE_C15H7.3
uniprot id: P34337
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

6239:CELE Y97E10AM.1
gene id: 6239:CELE_Y97E10AM.1
uniprot id: Q9N2V1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C29E4.10
gene id: 6239:CELE_C29E4.10
uniprot id: Q95QT2
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.
messages: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.

6239:CELE M02D8.3
gene id: 6239:CELE_M02D8.3
uniprot id: Q21461
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y11D7A.3
gene id: 6239:CELE_Y11D7A.3
uniprot id: Q2A7S9
uniprot id: Q9XWR7
uniprot id: X5LXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C47E12.3
gene id: 6239:CELE_C47E12.3
uniprot id: A0A061ACH9
uniprot id: Q18679
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE F21F3.3
gene id: 6239:CELE_F21F3.3
uniprot id: P91266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE K07C5.4
gene id: 6239:CELE_K07C5.4
uniprot id: Q21276
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for 60S ribosomal subunit synthesis.
messages: nucleolus

6239:CELE Y22F5A.1
gene id: 6239:CELE_Y22F5A.1
uniprot id: O62412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C33C12.8
gene id: 6239:CELE_C33C12.8
uniprot id: O16581
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

6239:CELE T10F2.3
gene id: 6239:CELE_T10F2.3
uniprot id: Q09353
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: Nucleus envelope
messages: Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.
messages: RNAi-mediated knockdown causes increased presence of smo-1 conjugates during the first embryonic mitotic division.

6239:CELE B0024.11
gene id: 6239:CELE_B0024.11
uniprot id: Q17426
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

6239:CELE T07D4.2
gene id: 6239:CELE_T07D4.2
uniprot id: Q22306
names: Similarity
messages: Belongs to the UPF0046 family.

6239:CELE F17E9.12
gene id: 6239:CELE_F17E9.12
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F54B11.3
gene id: 6239:CELE_F54B11.3
uniprot id: Q20745
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the unc-83-unc-84 LINC complex which contains at least unc-83 and unc-84 (PubMed:11748140, PubMed:16481402). Within the unc-83-unc-84 LINC complex interacts (via C-terminus) with unc-83; the interaction is probably required to recruit unc-83 to the nuclear membrane (PubMed:11748140, PubMed:16481402). Most likely interacts with anc-1; the interaction is probably required to recruit anc-1 to the nuclear envelope (PubMed:12169658). Interacts (via C-terminus) with zyg-12 (via C-terminus); the interaction is direct (PubMed:27956467). May interact with lmn-1; this interaction may be required to complete the connection between the nuclear lamina and the cytoskeleton (PubMed:25057012).
messages: Expressed in all cells of embryos from the 26-cell stage (PubMed:10375507, PubMed:11907270). Then, it is ubiquitously expressed throughout the development (PubMed:10375507, PubMed:11907270). Not expressed between fertilization and the 26-cell stage (PubMed:11907270).
messages: Expressed in all somatic cells (PubMed:11907270, PubMed:27956467). Not expressed in germ cells in the mitotic and transition zones of the gonad (PubMed:11907270). One study shows expression at the beginning of the late pachytene stage in the proximal gonad, but there is no expression in the male germline, suggesting expression is specific to oogenesis in hermaphrodites (PubMed:27956467).
messages: Induced by DNA-damage.
messages: Involved in nuclear migration and anchoring in hypodermal precursor cells (PubMed:10375507, PubMed:11748140, PubMed:12169658, PubMed:11907270, PubMed:16481402, PubMed:20921138, PubMed:21411627, PubMed:23150597, PubMed:25023515, PubMed:25057012). Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton (PubMed:12169658). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402). Its role in nuclear migration may be in association with lamin, lmn-1 (PubMed:25057012). Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization (PubMed:21798253). Not required for centrosome attachment to the nucleus (PubMed:10375507, PubMed:11907270). Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells (PubMed:25023515). May be involved in DNA damage repair through an association with zyg-12 (PubMed:27956467). Potentially has roles in homologous recombination, double strand break repair and meiotic recombination (PubMed:27956467). Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links (PubMed:27956467).
messages: Nucleus inner membrane
messages: The SUN domain probably plays a role in the nuclear anchoring and/or migration. Required for the localization of unc-83 and anc-1 at the nuclear membrane.
messages: cytoskeleton

6239:CELE F57B10.9
gene id: 6239:CELE_F57B10.9
uniprot id: O44735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

6239:CELE C15H11.1
gene id: 6239:CELE_C15H11.1
uniprot id: Q9XVS6
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C09G4.1
gene id: 6239:CELE_C09G4.1
uniprot id: G5ED45
uniprot id: X5LPS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Catalyzes the acylation of sphingoid bases to form ceramides. Sphingolipids from Caenorhabditis elegans contain exclusively isosphingoid bases. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons.
messages: Membrane

6239:CELE C26C6.1
gene id: 6239:CELE_C26C6.1
uniprot id: G5EEY5
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K01D12.14
gene id: 6239:CELE_K01D12.14
uniprot id: G5EGC7
names: Similarity
messages: Belongs to the FAX family.

6239:CELE ZK1127.3
gene id: 6239:CELE_ZK1127.3
uniprot id: Q23403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

6239:CELE Y73E7A.7
gene id: 6239:CELE_Y73E7A.7
uniprot id: Q9GUM2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3 and bre-5.
messages: Membrane
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein.

6239:CELE Y105E8A.20
gene id: 6239:CELE_Y105E8A.20
uniprot id: B3KYC0
uniprot id: Q8WQA1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE Y110A2AL.8
gene id: 6239:CELE_Y110A2AL.8
uniprot id: H2L0G5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the patched family.
messages: Embryonic lethal with embryos displaying a fluid-filled appearance and dying at hatching. RNAi-mediated knockdown results in high levels of embryonic and larval lethality. Dead and dying mutants do not respond to touch, display extensive vacuolation, molting defects which include unshed cuticles and in particular male specific molting defects that prevent unfurling of the mature tail rays. Surviving mutants are shorter in length and display defective egg-laying and abnormal vulval morphogenesis.
messages: Expressed in the hypodermis of embryos prior to hatching and expression is enhanced in the hypodermis before each molt. Expressed during larval development in the excretory duct at the L1 stage, and during morphogenesis of the somatic gonad and vulva during the L3 and L4 stages with prominent expression in the uterine seam cell and toroidal vulE and vulD cells.
messages: In males, expressed in the precursor and mature sensory rays, the cloaca, and pre-anal ganglia and cephalic neurons. Also expressed in five cells in the valve region between the seminal vesicle and vas deferens of the somatic gonad.
messages: Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting.
messages: adherens junction

6239:CELE F07H5.10
gene id: 6239:CELE_F07H5.10
uniprot id: Q19174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE C48G7.3
gene id: 6239:CELE_C48G7.3
uniprot id: G5ECF0
uniprot id: G5EDQ3
uniprot id: G5EG71
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

6239:CELE C01B4.6
gene id: 6239:CELE_C01B4.6
uniprot id: G5ECR6
names: Similarity
messages: Belongs to the aldose epimerase family.

6239:CELE E03H4.10
gene id: 6239:CELE_E03H4.10
uniprot id: O17741
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F35G12.11
gene id: 6239:CELE_F35G12.11
uniprot id: Q20057
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the E(R) family.
messages: Cytoplasm
messages: Expressed from early embryogenesis (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475).
messages: Expressed in the germline (at protein level).
messages: May form a homodimer (PubMed:31147388). Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the complex interacts with pid-1 (PubMed:31147388, PubMed:31216475). Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the complex interacts with tost-1 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts with pid-3 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts with tofu-6 (via the RRM domain) (PubMed:31216475). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of 21U-RNAs (PubMed:31147388).
messages: Nucleus
messages: RNAi-mediated knockdown results in chromosome segregation and cell division defects in early embryos (PubMed:31216475). RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown disrupts the localization of tofu-6 to the perinuclear region of the germline (PubMed:31216475). RNAi-mediated knockdown results in larger tofu-6- and pid-3-expressing foci (PubMed:31216475). RNAi-mediated knockdown results in decreased expression of tost-1 in the germline and in embryos (PubMed:31216475).
messages: Required for chromosome segregation and cell division in early embryos (PubMed:31216475). Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475).
messages: perinuclear region

6239:CELE F11G11.12
gene id: 6239:CELE_F11G11.12
uniprot id: P91250
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T14G12.4
gene id: 6239:CELE_T14G12.4
uniprot id: Q22510
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the 4 descendants of the D blastomere in embryos at about the 185 cells stage and in many other unidentified cells located more anteriorly.
messages: Nucleus
messages: RNAi-mediated knockdown by injection into adults causes slow and spatially restricted movement of about 30% of their L1 larval progeny, which nonetheless grow normally and do not display any obvious phenotype as late larvae or adults (PubMed:11044397). However, simultaneous knockdown of forkhead gene pes-1 causes 12% of eggs produced by hermaphrodites to arrest development at late stages of embryogenesis and 81% arrest after hatching as L1 stage larvae (PubMed:11044397).
messages: Transcription factor (By similarity). Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1 (PubMed:11044397).

6239:CELE B0554.7
gene id: 6239:CELE_B0554.7
uniprot id: A0A0K3ART0
uniprot id: A0A0K3AVB0
uniprot id: A0A0K3AXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE Y46H3C.3
gene id: 6239:CELE_Y46H3C.3
uniprot id: Q9N4W0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T27D12.2
gene id: 6239:CELE_T27D12.2
uniprot id: G5EDQ0
uniprot id: Q22833
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y38F1A.3
gene id: 6239:CELE_Y38F1A.3
uniprot id: Q9XWL9
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the patched family.
messages: Degraded in a lysosome-dependent manner before hatching.
messages: First expressed in hypodermal, seam, and P cells at the 3-fold stage during embryogenesis (at protein level) (PubMed:33872306). During late embryogenesis, expressed in hypodermal and P neural progenitor cells (at protein level) (PubMed:33872306). At the late L1 larval stage, expressed in the descendants of P cells, rectal epithelial F, K, and U cells and seam cells (at protein level) (PubMed:33872306).
messages: Transporter, which promotes the endocytosis-mediated degradation of hedgehog-related proteins such as grl-7 in order to establish the capacity of progenitor cells to maintain quiescence in arrested L1 stage larvae.

6239:CELE C32E8.2
gene id: 6239:CELE_C32E8.2
uniprot id: P91128
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the 60S large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs.
messages: Cytoplasm

6239:CELE F36D3.9
gene id: 6239:CELE_F36D3.9
uniprot id: O45466
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F18A12.5
gene id: 6239:CELE_F18A12.5
uniprot id: O16789
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE Y53C10A.12
gene id: 6239:CELE_Y53C10A.12
uniprot id: G5EFT5
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: Expressed in intestinal cells, body wall muscle cells, and hypodermal cells, as well as many neurons in the head and tail.
messages: Forms homodimers and homotrimers (PubMed:29042483, PubMed:22265419). Component of the DHIC (ddl-1-containing hsf-1 inhibitory complex), which contains at least ddl-1, ddl-2, hsb-1 and hsf-1 (PubMed:22265419). Within the complex, interacts with ddl-1 (PubMed:22265419). Formation of the DHIC may be dependent upon the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:22265419).
messages: Functions as a stress-inducible and DNA-binding transcription factor, playing a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:29042483, PubMed:15611166, PubMed:22265419). Upon exposure to heat and other stress stimuli, activates gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of target genes, such as the HSPs (PubMed:29042483, PubMed:27688402, PubMed:15611166, PubMed:22265419). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences in HSEs (PubMed:29042483, PubMed:27688402). Involved in positive modulation of expression of heat shock protein hsp-16.2 in response to heat shock; may act in concert with homeodomain-interacting protein kinase hpk-1 (PubMed:15611166, PubMed:28198373, PubMed:29036198). In response to heat shock or starvation, required for the modulation of lifespan, and protection against aberrant protein aggregation proteotoxicity; may act in parallel with the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:15611166, PubMed:18331616, PubMed:28198373, PubMed:29036198). Plays a role in modulating autophagy, in response to a moderate and short-term heat shock, also known as a hormetic heat shock (PubMed:28198373). Involved in positive modulation of ascaroside pheromone biosynthesis in response to heat shock, perhaps by directly activating transcription of peroxisomal fatty acid beta-oxidation genes (PubMed:26759377). Required in modulating the response to infection by either Gram-negative or Gram-positive bacteria, perhaps acting via regulation of expression of Hsp90/daf-21 and members of the small heat shock protein (HSP20) family (PubMed:16916933, PubMed:29042483). May play a role downstream of the daf-16/FOXO and daf-2 signaling pathway in response to bacterial pathogens (PubMed:16916933). Modulates …
messages: Induced by heat shock.
messages: Nucleus
messages: Phosphorylated.
messages: RNAi-mediated knockdown increases susceptibility to Gram-negative bacterium P.aeruginosa in wild-type and in a daf-2 mutant background (PubMed:16916933). Abolishes both median and maximum lifespan extension caused by starvation (PubMed:18331616). Fails to prevent paralysis due to proteotoxicity under starvation conditions (PubMed:18331616). Prevents the heat shock-induced increase in lgg-1/Atg8 punctae in body-wall muscles, nerve ring neurons and proximal intestinal cells (PubMed:28198373). Accelerates death upon exposure to the Gram-negative bacterium P.aeruginosa PA14 (PubMed:29042483).
messages: Sumoylated (PubMed:29036198). Sumoylation may inhibit transcriptional activity in response to heat shock (PubMed:29036198).

6239:CELE F25E2.4
gene id: 6239:CELE_F25E2.4
uniprot id: Q19782
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE ZK1236.7
gene id: 6239:CELE_ZK1236.7
uniprot id: P34623
names: Similarity
messages: Belongs to the DDRGK1 family.

6239:CELE T10G3.2
gene id: 6239:CELE_T10G3.2
uniprot id: P92019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F55A12.9
gene id: 6239:CELE_F55A12.9
uniprot id: H2KZ00
uniprot id: H2KZ01
uniprot id: Q86NJ5
uniprot id: Q95R13
names: Similarity
messages: Belongs to the TENT family.

6239:CELE T19H12.10
gene id: 6239:CELE_T19H12.10
uniprot id: O01616
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y57A10A.16
gene id: 6239:CELE_Y57A10A.16
uniprot id: Q9NA81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

6239:CELE ZC455.6
gene id: 6239:CELE_ZC455.6
uniprot id: Q23336
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE F23F12.4
gene id: 6239:CELE_F23F12.4
uniprot id: P46500
names: Developmental Stage
names: Function
messages: May have a role in embryogenesis.
messages: Thirteenfold increase in expression between 4-cell and 12-cell embryos.

6239:CELE R57.1
gene id: 6239:CELE_R57.1
uniprot id: G8JYE4
uniprot id: P91406
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Membrane

6239:CELE C04F12.10
gene id: 6239:CELE_C04F12.10
uniprot id: Q9XVE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

6239:CELE Y71F9B.3
gene id: 6239:CELE_Y71F9B.3
uniprot id: Q9N4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE ZK652.3
gene id: 6239:CELE_ZK652.3
uniprot id: P34661
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the UFM1 family.
messages: Expressed in the intestine and head neurons.
messages: Interacts with odr-8; leading to deufmylation.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc-1, and probably the ufm-1-ligase E3 enzyme ufl-1 (PubMed:23449979).

6239:CELE M01E11.3
gene id: 6239:CELE_M01E11.3
uniprot id: P91399
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RMI1 family.
messages: Chromosome
messages: Component of the RMI complex, containing at least top-3, rmh-1 and rmh-2 (By similarity). Component of the BTR double Holliday Junction dissolution complex composed of at least him-6, top-3, rmh-1 and rmif-2, which is involved in double strand break repair in the germline (Probable). Interacts with rmif-2; the interaction is direct and is required for mutual stability and localization at nuclear foci (PubMed:34252074). May interact with him-6; the interaction is required for mutual stability and localization at nuclear foci (PubMed:27011106). May interact with top-3 (PubMed:27011106).
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells (By similarity). Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break repair in the germline (Probable). Promotes top-3 binding to double Holliday junctions (DHJ) and hence stimulates top-3-mediated dissolution (By similarity). Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex components rmif-2 and him-6 at nuclear foci during meiotic recombination (PubMed:27011106, PubMed:34252074). Plays a role in double strand break repair by regulating the accumulation of rad-51 at double strand breaks during meiosis (PubMed:27011106). Positively regulates chiasma formation and DNA crossover designation, formation and positioning on chromosome arms (away from the chromosome center) during meiotic homologous recombination (PubMed:27011106, PubMed:34252074). Specifically localizes him-6 to DNA crossover sites along chromosome arms (PubMed:27011106). Also plays a role in the repair of non-crossover homologous recombination intermediates during meiosis (PubMed:27011106). Not required for chromosome pairing and synapsis (PubMed:27011106). Together with rmh-2, positively regulates larval development (PubMed:27011106).
messages: Expressed in the germline (at protein level).
messages: Expressed in the germline throughout early pachynema in meiotic prophase I (at protein level) (PubMed:27011106, PubMed:34252074). Expression progressively increases during pachytene in meiotic prophase I, peaking during mid-pachytene and reducing at late pachytene (at protein level) (PubMed:27011106).
messages: Nucleus
messages: nucleoplasm

6239:CELE T04F8.2
gene id: 6239:CELE_T04F8.2
uniprot id: Q22162
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK669.4
gene id: 6239:CELE_ZK669.4
uniprot id: Q23571
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown results in reduced monomethyl branched-chain fatty acid generation and also results in larval arrest in the subsequent generation.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component (By similarity). Required for the catabolism of branched-chain amino acids and the subsequent synthesis of monomethyl branched-chain fatty acids, which are important for regulating postembryonic growth (PubMed:26683372).
messages: Ubiquitously expressed.
messages: cilium
messages: cytosol
messages: dendrite

6239:CELE F59A3.4
gene id: 6239:CELE_F59A3.4
uniprot id: P91354
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK354.6
gene id: 6239:CELE_ZK354.6
uniprot id: P91566
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE W01B6.5
gene id: 6239:CELE_W01B6.5
uniprot id: Q23102
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE K02A4.1
gene id: 6239:CELE_K02A4.1
uniprot id: P54688
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
messages: Cytoplasm
messages: Expression decreases with increasing age.
messages: RNAi-mediated knockdown extends mean lifespan by 25% and maximum lifespan by 19%, increases maximum moving speed, and increases levels of the enzyme substrates, L-leucine, L-isoleucine and L-valine.

6239:CELE Y69H2.8
gene id: 6239:CELE_Y69H2.8
uniprot id: Q9U1U2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F44C8.1
gene id: 6239:CELE_F44C8.1
uniprot id: O16362
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F52H3.6
gene id: 6239:CELE_F52H3.6
uniprot id: Q27501
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE W06H3.1
gene id: 6239:CELE_W06H3.1
uniprot id: Q9XXN2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Cytoplasm
messages: Egg-laying defects, defective oogenesis in 23% of mutants, reduced brood size and increased resistance to oxidative stress inducer paraquat (PubMed:20578245, PubMed:21248201). Abnormal mitochondrial morphology with mitochondria appearing larger, thinner and connected with large pores in the outer mitochondrial membrane (PubMed:21248201). Mitochondria also have elongated and curved cristae that are stacked with a reduced number of junctions (PubMed:21248201). Double knockout with immt-1 results in a more reduced brood size and enhanced resistance to paraquat-induced oxidative stress as compared to the single mutant, and in addition, mutants are slower swimmers, have increased hydrogen peroxide-induced reactive oxygen species (ROS), and reduced mitochondrial mass accompanied by reduced superoxide anion oxidation (PubMed:20578245).
messages: Expressed in embryos.
messages: Expressed in the gonads and muscle cells.
messages: Mitochondrion inner membrane
messages: Sustains mitochondrial morphology probably through maintaining cristae morphology (PubMed:20578245, PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE K03H9.2
gene id: 6239:CELE_K03H9.2
uniprot id: Q09578
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE DY3.7
gene id: 6239:CELE_DY3.7
uniprot id: G5EFD9
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in embryos, larvae and in adults. Expressed in the developing vulva at the L4 larval stage and in the hypodermis at the L3 larval stage.
messages: Expressed in the germline.
messages: May interact with tetraspanin tsp-12; the interaction promotes sup-17 cell membrane localization.
messages: Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification (PubMed:9428412, PubMed:9409830, PubMed:16197940). By modulating glp-1/Notch signaling, plays a role in germline development (PubMed:16197940). Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development (PubMed:28068334). Probably by shedding ephrin efn-4, regulates axon guidance of SDQL neuron during development (PubMed:26903502).
messages: RNAi-mediated knockdown in a glp-1 (ar202) constitutively active mutant background restores fertility.

6239:CELE T21E8.3
gene id: 6239:CELE_T21E8.3
uniprot id: G5EG03
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK524.3
gene id: 6239:CELE_ZK524.3
uniprot id: B3WFV4
uniprot id: Q23511
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE ZK896.9
gene id: 6239:CELE_ZK896.9
uniprot id: E5QCI0
uniprot id: O02345
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T25F10.6
gene id: 6239:CELE_T25F10.6
uniprot id: Q23050
names: Similarity
messages: Belongs to the calponin family.

6239:CELE K11G9.3
gene id: 6239:CELE_K11G9.3
uniprot id: Q23008
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C25A1.5
gene id: 6239:CELE_C25A1.5
uniprot id: Q9XVS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE W01B11.2
gene id: 6239:CELE_W01B11.2
uniprot id: A0A8S5I9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE K02B12.4
gene id: 6239:CELE_K02B12.4
uniprot id: Q3LRZ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with bar-1, dsh-2, gsk-3, and mig-5.
messages: Reporter transgenes fail to show detectable expression indicating that axl-1 may be expressed at low levels.
messages: Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development.
messages: Worms exhibit defects in excretory cell development and axonal migration.

6239:CELE F29C12.3
gene id: 6239:CELE_F29C12.3
uniprot id: G5EFK2
uniprot id: G5EFN2
names: Similarity
messages: Belongs to the RICTOR family.

6239:CELE F42A9.1
gene id: 6239:CELE_F42A9.1
uniprot id: D5MCN8
uniprot id: H2KZC9
names: Function
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

6239:CELE F55C10.2
gene id: 6239:CELE_F55C10.2
uniprot id: Q20805
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F28F9.1
gene id: 6239:CELE_F28F9.1
uniprot id: G5EBU4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected in a few nuclei in the embryonic head as the embryo reaches morphogenesis stage. Expressed in an increasing number of nuclei as embryonic development progresses such that by the 1.5-fold stage it is detected in a large number of neuronal cells in the head and a few cells in the pharynx. At the 1.5-fold stage, expression is also prominent in motorneurons in the ventral cord and in neurons in tail ganglia. This expression is maintained during the 3-fold stage, but is reduced to undetectable levels in most cells before hatching. By the L1/L2 stage, expression is detected transiently in postembryonic motorneurons.
messages: Expressed in the six touch receptor neurons (TRNs) but not in the FLP and PVD neurons (PubMed:30291162). Expressed in the M4 cholinergic motor neuron (PubMed:25474681).
messages: Nucleus
messages: Transcription factor (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162). Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA (PubMed:12835394). Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162). Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46 (PubMed:30291162). As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162). Required for axon guidance (PubMed:12835395). Involved in the proper development of the pharynx (PubMed:12835395). Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron (PubMed:25474681). Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter (PubMed:12835394, PubMed:12835395). May also act as a transcriptional activator of the homeodomain ceh-28 (PubMed:25474681).
messages: Worms exhibit a starved appearance, are unable to swallow food and die at the L1 larval stage (PubMed:12835395). RNAi-mediated knockdown causes significant reduction in expression of mec-17 (PubMed:30291162).

6239:CELE C41G7.3
gene id: 6239:CELE_C41G7.3
uniprot id: Q93367
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout the germline and in oocytes (at protein level).
messages: May interact with wago-4.
messages: RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline (PubMed:30728462). Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline (PubMed:30728462).
messages: RNAi-mediated knockdown results in increased apoptosis and increased sensitivity to DNA damage-induced apoptosis in response to ionizing radiation in the germline.
messages: The KH-like 3 domain is required for binding to RNA.
messages: perinuclear region

6239:CELE F43D9.6
gene id: 6239:CELE_F43D9.6
uniprot id: B3CKG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
messages: Cytoplasm

6239:CELE D2063.1
gene id: 6239:CELE_D2063.1
uniprot id: Q9UAT1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE M04D8.2
gene id: 6239:CELE_M04D8.2
uniprot id: Q21508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE ZC247.3
gene id: 6239:CELE_ZC247.3
uniprot id: P20154
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in ADL, AVJL, AIZL, RICL, RIF and AVG neurons.
messages: Nucleus
messages: Probable transcription factor which is required for asymmetric division of vulval blast cells (PubMed:1970421, PubMed:15466489). Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons (PubMed:19561603). Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons (PubMed:29672507). Plays a role in the differentiation of the ADL sensory neurons (PubMed:29672507).

6239:CELE ZK328.5
gene id: 6239:CELE_ZK328.5
uniprot id: G5EEH9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin GLFG family.
messages: Chromosome
messages: Cytoplasmic granule
messages: Expressed in embryos (at protein level).
messages: Nucleus envelope
messages: Nucleus membrane
messages: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC) (PubMed:20335358, PubMed:28122936). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution (PubMed:28122936). Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase (PubMed:22238360). Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes (PubMed:20335358). Binds nos-2 mRNA, probably indirectly, and promotes its accumulation in P granules (PubMed:20335358).
messages: Part of the NPC.
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:12937276, PubMed:28122936). Two-cell embryos appear to lack nuclei and pronuclei (PubMed:12937276). Also causes severe defects in mitosis (PubMed:22238360, PubMed:28122936). Chromosome condensation is severely impaired during prophase (PubMed:28122936). Centrosome assembly during prophase and prometaphase and their subsequent resolution are impaired which results from impaired nuclear import of hcp-4 (PubMed:28122936). Impaired sister chromatin segregation (PubMed:28122936). Loss of nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase (PubMed:22238360). Irregular nuclear membrane distribution of nucleoporin npp-13 (PubMed:28122936). Mutants display P granule dispersion (PubMed:20335358).
messages: The Nup98 and Nup96 chains are autoproteolytically processed from a single precursor protein.
messages: nuclear pore complex

6239:CELE F55A3.3
gene id: 6239:CELE_F55A3.3
uniprot id: Q9N5R9
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity). In embryos, promotes cell cycle progression and chromosomal segregation (PubMed:25446273, PubMed:30336114). Plays a role in the development of the anterior pharynx during embryonic development (PubMed:30336114).
messages: Component of the FACT complex, a stable heterodimer of spt-16 and hmg-3 or hmg-4.
messages: Expressed in the germline and somatic cells.
messages: Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage (PubMed:30336114).
messages: Nucleus
messages: RNAi-mediated knockdown in embryos results in failed hatching in 83% of animals (PubMed:30336114). In addition, these embryos lack the anterior pharynx (PubMed:30336114). RNAi-mediated knockdown at the L4 larval stage results in failed development of the anterior pharynx (PubMed:30336114). RNAi-mediated knockdown at this stage results in defective cell cycle initiation, duration and completion in embryos, and abnormalities in chromosome segregation (PubMed:25446273, PubMed:30336114).

6239:CELE T28H10.3
gene id: 6239:CELE_T28H10.3
uniprot id: G5EBF4
names: Similarity
messages: Belongs to the peptidase C13 family.

6239:CELE K10C9.3
gene id: 6239:CELE_K10C9.3
uniprot id: O61887
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RNase T2 family.
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in the pharynx, hypodermis, muscle cells, sheath cells, intestinal cells, the vulva and tail regions.
messages: Lysosome
messages: Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes.

6239:CELE C45B2.5
gene id: 6239:CELE_C45B2.5
uniprot id: Q95YD1
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE K03E6.1
gene id: 6239:CELE_K03E6.1
uniprot id: Q21192
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in a restricted set of neurons, and epithelial cells of the uterus and the excretory system, late in embryogenesis at about 300 minutes of development (PubMed:10068647). Expression in neurons continues throughout adulthood (PubMed:10068647). Expressed asymmetrically, only in the left neuron (ASEL), of the ASER and ASEL chemosensory pair (PubMed:10068647). Expressed in the interneuron PVT during embryogenesis (PubMed:12490565).
messages: Nucleus
messages: Transcription factor (By similarity). Required for the terminal differentiation of sensory- and motor-neurons, especially GABAergic neurons, and for morphological aspects of uterine development (PubMed:10068647). Plays a role in the cell-type-specific regulation of glutamic acid decarboxylase unc-25 (PubMed:10068647). Involved in promoting sleep-like behavioral quiescence, acting by modulating expression of transcription factor aptf-1 in the single sleep-active ring interneuron RIS (PubMed:26949257). Plays a role in regulation of RIS differentiation (PubMed:14568548). Required for the functional asymmetry of the ASER and ASEL chemosensory neuron pair, conferring the ability to discriminate sodium from chloride, perhaps by modulating expression of receptor-type guanylate cyclases, such as gcy-5 (PubMed:11287956, PubMed:21555395). Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein ceh-14, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT (PubMed:12490565). May play a role in the functions of the excretory gland cell (PubMed:10068647).

6239:CELE F32H2.9
gene id: 6239:CELE_F32H2.9
uniprot id: P91873
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE K12D9.4
gene id: 6239:CELE_K12D9.4
uniprot id: P91379
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F55D10.3
gene id: 6239:CELE_F55D10.3
uniprot id: Q20826
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although glit-1 contains an extracellular carboxylesterase-like domain, the characteristic Ser-Glu-His catalytic triad present in acetylcholinesterase is replaced by two Asp residues and an Arg, suggesting that glit-1 lacks catalytic activity.
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Expressed in larvae and adults. Expressed in dopaminergic neurons in L4 larvae.
messages: Expressed in the pharynx, intestine, and in several cells in the head including dopaminergic neurons.
messages: Probable neuronal cell surface protein thought to be involved in cell-cell-interactions (Probable). Confers protection against oxidative stress (PubMed:29346364). Plays a role in protecting dopaminergic neurons against oxidative stress-induced neurodegeneration (PubMed:29346364).

6239:CELE Y55F3BL.2
gene id: 6239:CELE_Y55F3BL.2
uniprot id: U4PCA8
uniprot id: U4PS08
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K08E3.3
gene id: 6239:CELE_K08E3.3
uniprot id: Q9XUS7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FNBP1 family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Double knockout with toca-1 results in nearly 100% of mutants with defective endocytosis by oocytes characterized by either reduced or non-detectable yolk protein in the oocytes and by an accumulation of aggregated yolk protein in the pseudocoelomatic space. Double knockout mutants with toca-1 also produce 20% fewer eggs compared to wild-type animals and there is some embryonic lethality whereby the dying embryos display defective morphogenesis including failed epidermal enclosure with extruding gut cells and increased width of the intestinal lumen (PubMed:19798448). This perhaps results from failed intercalation and migration of hypodermal cells and irregular protein trafficking as indicated by an accumulation of the cell junction protein ajm-1 and diffuse localization of actin at cell junctions (PubMed:19798448, PubMed:26578656). These double mutants also demonstrate defective endosomal sorting of recycling cargo proteins such as mig-14 (PubMed:25775511).
messages: Interacts (via SH3 domain) with wsp-1 and abi-1 (PubMed:19798448). Interacts with cdc-42 and (via SH3 domain) with wve-1 (PubMed:25775511).
messages: Plays a role in protein trafficking, actin organization and embryonic morphogenesis (PubMed:19798448). Potentially acts as cdc-42 effector (PubMed:25775511). May play a role in egg laying (PubMed:19798448). Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14 (PubMed:19798448, PubMed:25775511). Also, together with toca-2, controls the distribution of actin at cell junctions (PubMed:19798448, PubMed:26578656).
messages: Recycling endosome
messages: Ubiquitously expressed in developing embryos.

6239:CELE Y66D12A.21
gene id: 6239:CELE_Y66D12A.21
uniprot id: Q95PJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

6239:CELE F36H1.5
gene id: 6239:CELE_F36H1.5
uniprot id: Q20106
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: By heme deficiency.
messages: Cell membrane
messages: Heme transporter that mediates heme uptake across the plasma membrane.
messages: RNAi-mediated knockdown results in the heme accumulation in the intestine under low heme conditions (PubMed:28581477). Simultaneous RNAi-mediated knockdown with hrg-7 results in defective heme deficiency sensing (PubMed:28581477).

6239:CELE C48E7.5
gene id: 6239:CELE_C48E7.5
uniprot id: G5EBT7
names: Caution
names: Similarity
messages: Belongs to the cuticular collagen family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F16H6.4
gene id: 6239:CELE_F16H6.4
uniprot id: A0A0K3ARY7
uniprot id: A0A0K3AUT5
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE T21B4.2
gene id: 6239:CELE_T21B4.2
uniprot id: O18097
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE E03H12.10
gene id: 6239:CELE_E03H12.10
uniprot id: Q23058
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE T05C3.7
gene id: 6239:CELE_T05C3.7
uniprot id: Q86B41
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y38A8.2
gene id: 6239:CELE_Y38A8.2
uniprot id: Q23237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

6239:CELE C56G3.1
gene id: 6239:CELE_C56G3.1
uniprot id: G8JY12
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE B0304.6
gene id: 6239:CELE_B0304.6
uniprot id: Q10935
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F08B12.1
gene id: 6239:CELE_F08B12.1
uniprot id: Q19188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane

6239:CELE F54D1.2
gene id: 6239:CELE_F54D1.2
uniprot id: G5EFU8
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE R01E6.4
gene id: 6239:CELE_R01E6.4
uniprot id: A0A0K3ATC5
uniprot id: G5EDF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE F32H2.5
gene id: 6239:CELE_F32H2.5
uniprot id: P91871
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

6239:CELE C03D6.8
gene id: 6239:CELE_C03D6.8
uniprot id: Q17606
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24 (By similarity).
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).
messages: nucleolus

6239:CELE C35D10.9
gene id: 6239:CELE_C35D10.9
uniprot id: P30429
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Abundantly expressed during embryogenesis and to a lesser extent in larvae and adults (PubMed:1286611). Expression starts at the 100-cell stage and persists through embryogenesis (at protein level) (PubMed:9027313). Not expressed in larvae and adults (at protein level) (PubMed:9027313).
messages: Associates as an asymmetric homodimer with ced-9 (PubMed:16208361, PubMed:9027313, PubMed:15383288). Upon release from ced-9, forms an octamer, known as the apoptosome, and interacts with ced-3; the interaction results in ced-3 autoproteolytic cleavage and activation (PubMed:20434985, PubMed:24065769). The octamer (a tetramer of an asymmetric dimer) also interacts with two processed ced-3 to form a stable holoenzyme (PubMed:20434985). Interacts with sex-determining protein fem-1 (PubMed:10764728). May form a complex composed of ced-3, ced-4 and mac-1 or of ced-9, ced-4 and mac-1 (PubMed:10101135). Within the complex, interacts with ced-4 (PubMed:10101135).
messages: Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development (PubMed:3955651). During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1 (PubMed:9927601). May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway (PubMed:21901106). Regulates CEP neuron apoptosis in response to high Al(3+) levels (PubMed:23106139). During male tail morphogenesis, promotes apoptosis of the tail-spike cell upstream of ced-3 but independently of egl-1 and ced-9 (PubMed:17329362). May play a role in sex-specific cell apoptosis, probably by promoting ced-3-mediated cleavage of sex-determining protein fem-1 (PubMed:10764728). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and ced-9 and upstream of ced-3 apoptotic pathway (PubMed:26074078). Downstream of calreticulin crt-1 and upstream of ced-3 and independently of egl-1 and ced-9, plays a role in the initial steps of axonal regrowth following axotomy (PubMed:22629231). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3, regulates temporal cell fate patterning during larval development (PubMed:25432023). May play a role in resistance to S.typhimurium-mediated infection (PubMed:11226309).
messages: Mitochondrion
messages: Mutants exhibit a block in almost all programmed cell deaths that normally occur during development (PubMed:1286611). RNAi-mediated knockdown causes a defect in egg laying in a small proportion of animals (PubMed:25432023). Also causes a moderate increase in CEP neuron survival in response to high Al(3+) levels (PubMed:23106139). In an ain-1 mutant background, enhances the proportion of animals arrested at the larval stage, with egg-laying defects and with a ruptured vulva (PubMed:25432023).
messages: Plays a major role in programmed cell death (PubMed:1286611, PubMed:8706125). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation (PubMed:15383288, PubMed:16208361, PubMed:20434985, PubMed:24065769). Also forms a holoenzyme with processed ced-3 enhancing ced-3 activity (PubMed:20434985).
messages: Prevents programmed cell death.
messages: perinuclear region

6239:CELE C24G7.4
gene id: 6239:CELE_C24G7.4
uniprot id: P91100
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F44G4.2
gene id: 6239:CELE_F44G4.2
uniprot id: Q20412
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

6239:CELE C54E4.5
gene id: 6239:CELE_C54E4.5
uniprot id: Q65CM5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

6239:CELE Y54E10A.16
gene id: 6239:CELE_Y54E10A.16
uniprot id: Q9N3E2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed in gut cells of the pretzel stage embryo and throughout the larval stages (PubMed:20687916). Expressed in adult males and hermaphrodites, in the pharynx, body hypodermis, and intestine (PubMed:20687916). Expressed in support cells of neuronal sensilla, such as amphid and phasmid socket cells in hermaphrodites, and cell bodies and processes of all sensory rays in males (PubMed:20687916).
messages: Induced by exposure to nano-polystyrene particles.
messages: Nucleus
messages: Putative transcription factor (PubMed:32758726). Acts in a TGF-beta-like pathway during development of male-specific genital sensilla (simple sense organs), known as rays (PubMed:20687916). Involved in production of reactive oxygen species (ROS), acting downstream of the TGF-beta-like dbl-1 signaling pathway (PubMed:32758726). Involved in locomotory behavior (PubMed:32758726).
messages: RNAi-mediated knockdown causes abnormal male tail development (PubMed:20687916). Abnormal fusion of structures in male-specific genital sensilla (simple sense organs) known as rays (PubMed:20687916). Abnormal fusion of rays 6 and 7 enhanced in a sma-6 mutant background (PubMed:20687916). Reduced fecundity in hermaphrodites (PubMed:20687916). In response to nano-polystyrene, causes decreased locomotion behavior and increased reactive oxygen species (ROS) production (PubMed:32758726). Intestine-specific RNAi-mediated knockdown causes increased ROS production and reduces expression of daf-16 and sod-3 (PubMed:32758726).

6239:CELE F59B1.9
gene id: 6239:CELE_F59B1.9
uniprot id: A0A168H5T6
uniprot id: G5EG88
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.
messages: Cell membrane
messages: Expressed in the body wall muscles that are arranged into four longitudinal bundles, some mechanosensory neurons, the head muscles and multiple interneurons. Not expressed in motor neurons (at protein level).
messages: Membrane
messages: Mutant worms are morphologically similar to the wild-type but exhibit mild swimming defects and are lethargic with their movement being interrupted by frequent pauses when crawling on a food-free environment (PubMed:24212673). On the same environment, in other occasions they display decreased rates of spontaneous reversal and steering, and slightly increased average speed (PubMed:23950710). Homozygotes are fully resistant to monepantel but heterozygotes are partially affected by the drug with reduced fertility and slightly impaired movement.
messages: Not expressed in embryos and L1 stage but expressed from L2 stage to adulthood in the body wall muscles (at protein level).
messages: Suppresses snf-3 mutant phenotype growth defects. Elicits no current in response to the broad-spectrum antiparasitic medicine ivermectin. This channel is allosterically sensitive to monepantel, an anthelmintic of the amino-acetonitrile derivatives (AADs) class, leading to muscle paralysis upon treatment with monepantel.

6239:CELE C53B4.7
gene id: 6239:CELE_C53B4.7
uniprot id: Q18801
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (PubMed:16650000). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5 (PubMed:10924467, PubMed:17135259, PubMed:17482642). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds (PubMed:20062796). Has a role in determining brood size (PubMed:10924467).
messages: Expressed throughout development, showing up-regulation between stages L2 and L4.
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 12% of wild-type N2.

6239:CELE F35C8.5
gene id: 6239:CELE_F35C8.5
uniprot id: Q20027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Membrane
messages: Probable sterol desaturase.

6239:CELE ZK643.1
gene id: 6239:CELE_ZK643.1
uniprot id: I2HAB8
uniprot id: I2HAB9
uniprot id: P30647
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE K08F4.3
gene id: 6239:CELE_K08F4.3
uniprot id: Q21352
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

6239:CELE Y32H12A.7
gene id: 6239:CELE_Y32H12A.7
uniprot id: Q9N534
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

6239:CELE B0035.11
gene id: 6239:CELE_B0035.11
uniprot id: Q17431
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LEO1 family.
messages: Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.
messages: Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
messages: Cytoplasm
messages: Expressed in both somatic cells and germ cells from the one-cell stage onwards.
messages: Nucleus
messages: RNAi-mediated knock-down is maternal effect embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells.

6239:CELE T17E9.1
gene id: 6239:CELE_T17E9.1
uniprot id: P46549
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility (PubMed:23064028). Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division (PubMed:23064028). Might play a role in cell cycle progression (PubMed:23064028). In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation (PubMed:26510792). Plays a role in meiotic recombination events (PubMed:26510792). Involved in pharyngeal pumping (PubMed:11733138).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STE20 subfamily.
messages: Expressed during embryogenesis (PubMed:23064028). Expressed in adults (PubMed:11733138).
messages: Expressed in the pharynx, including the pharyngeal muscle of the metacorpus, the isthmus, and the terminal bulb; in the intestine, including the pharyngeointestinal valve between the pharynx and the intestine, a structure near the anus likely to be the anal sphincter and the excretory cell and in several ring neurons.
messages: RNAi-mediated knockdown leads to embryonic lethality (PubMed:23064028). Increased and prolonged cortical contractility leading to a more persistent pseudocleavage in surviving embryos (PubMed:23064028). Decrease in rho-1 anterior cortex localization and increase in posterior cortex localization, leading to a loss of asymmetric rho-1 cortex localization during early embryonic cell division (PubMed:23064028). Increased cortical nmy-2 network between the foci, suggesting that the enhanced contractions are due to increased actomyosin contractility (PubMed:23064028). Reduction in the size of the anterior cortex and increase in the size of the posterior cortex during polarity establishment in the early embryo (PubMed:23064028). Leads to a delay in embryonic cell cycle progression (PubMed:23064028). Double RNAi-mediated knockdown with rho-1 results in loss of cortical contractility (PubMed:23064028).
messages: cell cortex
messages: cytoskeleton

6239:CELE AH6.4
gene id: 6239:CELE_AH6.4
uniprot id: Q09203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE T25B9.5
gene id: 6239:CELE_T25B9.5
uniprot id: A0A061ADQ6
uniprot id: Q22766
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE B0334.11
gene id: 6239:CELE_B0334.11
uniprot id: Q8I132
uniprot id: Q9XVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

6239:CELE T06C10.6
gene id: 6239:CELE_T06C10.6
uniprot id: Q22245
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE T05F1.8
gene id: 6239:CELE_T05F1.8
uniprot id: Q9XUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE W08E3.2
gene id: 6239:CELE_W08E3.2
uniprot id: G5EDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: perinuclear region

6239:CELE Y49E10.3
gene id: 6239:CELE_Y49E10.3
uniprot id: Q9XTT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

6239:CELE F35B12.10
gene id: 6239:CELE_F35B12.10
uniprot id: H9G2X9
uniprot id: H9G2Y0
uniprot id: Q7YX42
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of burs and pburs.
messages: Secreted

6239:CELE C34B7.4
gene id: 6239:CELE_C34B7.4
uniprot id: Q95ZX6
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

6239:CELE Y54G11A.2
gene id: 6239:CELE_Y54G11A.2
uniprot id: Q9XW03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

6239:CELE Y116A8C.30
gene id: 6239:CELE_Y116A8C.30
uniprot id: Q9U2S7
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

6239:CELE Y39B6A.24
gene id: 6239:CELE_Y39B6A.24
uniprot id: Q8MYN5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aspartic proteinase.
messages: Belongs to the peptidase A1 family.
messages: Expressed in intestinal cells.
messages: Induced in response to thermal stress in conditions where severe cold temperatures are followed by warmer temperatures (PubMed:29664006). In particular, induced in the warming phase (10 to 22 degrees Celsius) during the cold (4 degrees Celsius) to warm (22 degrees Celsius) temperature transition (PubMed:29664006).
messages: Secreted

6239:CELE K10C3.6
gene id: 6239:CELE_K10C3.6
uniprot id: O45666
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Homodimer (PubMed:22511885). Interacts with nuclear hormone receptors nhr-80 and nhr-66; the interactions are direct (PubMed:22511885). May interact with nuclear hormone receptors nhr-13, nhr-22, nhr-79, nhr-105, and nhr-256 (PubMed:22511885).
messages: Nucleus
messages: Orphan nuclear receptor (PubMed:25981666). Regulates expression of genes involved in fat metabolism and in maintaining homeostasis of fatty acid saturation, such as lipid desaturase fat-7, and acyl-CoA synthetase acs-2 (PubMed:25981666, PubMed:15719061, PubMed:22511885). May form part of a negative feedback loop with fat-7 to limit mitochondrial beta-oxidation, in which it stimulates expression of fat-7 and acs-2, and in turn fat-7 indirectly inhibits acs-2 and other genes also involved in beta-oxidation (PubMed:15719061). As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acting in concert with nuclear hormone receptor nhr-80, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation (PubMed:25554789, PubMed:26671266). In concert with nuclear hormone receptor nhr-66, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling (PubMed:22511885). Also involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptors nhr-13 and nhr-80 (PubMed:22511885). Plays a role in modulating mitochondrial morphology and function (PubMed:22511885). Plays a role in transgenerational lipid accumulation in response to a high-fat diet (PubMed:35140229).
messages: RNAi-mediated knockdown eliminates the effect of C11 or C12 chain fatty acids in activating fat-7 expression and blocks overexpression of fat-7 in acdh-11 mutants (PubMed:25981666). Increased ratio of stearic acid to oleic acid (C18:0/C18:1n9) (PubMed:15719061). Drastically reduces life span (PubMed:15719061, PubMed:25554789).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

6239:CELE C46H11.4
gene id: 6239:CELE_C46H11.4
uniprot id: Q95Q62
names: Activity Regulation
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Expressed in spermatheca.
messages: Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation (PubMed:9491893, PubMed:16186564). May also regulate ovulation downstream of actin cross-linker fln-1 (PubMed:23671426).
messages: Unlike mammalian IP3K, may not be regulated by calmodulin.

6239:CELE F38G1.2
gene id: 6239:CELE_F38G1.2
uniprot id: G5EEF1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

6239:CELE C34F11.5
gene id: 6239:CELE_C34F11.5
uniprot id: Q18462
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C27F2.6
gene id: 6239:CELE_C27F2.6
uniprot id: Q18261
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F45G2.4
gene id: 6239:CELE_F45G2.4
uniprot id: O62246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

6239:CELE R10H10.3
gene id: 6239:CELE_R10H10.3
uniprot id: Q21916
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y75B8A.22
gene id: 6239:CELE_Y75B8A.22
uniprot id: G5EDN3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cohesin complex (PubMed:12827206). Interacts with smc-1, smc-3, scc-1 and scc-3 (PubMed:12827206).
messages: Belongs to the timeless family.
messages: Expression is increased during late postembryonic development (PubMed:10550049). In embryos, there is diffuse nuclear expression at interphase, but this reduces by the metaphase-anaphase transition (PubMed:12827206). There is diffuse expression in pre-meiotic germline nuclei as the nuclei enter meiotic prophase and later in the diplotene and diakinesis phases of prophase (PubMed:12827206).
messages: Nucleus
messages: Plays an important role in chromosome cohesion during both mitosis and meiosis (PubMed:12827206). In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion (PubMed:12827206). It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase (PubMed:12827206). Implicated in influencing either the stability or loading of meiotic-specific cohesin subunit, rec8 (PubMed:12827206). Controls cell cycle exit and cell fusion to prevent the premature differentiation into adult cells (PubMed:15691769). Specifically, regulates hypodermal seam cell identity (PubMed:15691769).
messages: RNAi-mediated knockdown is embryonic lethal (PubMed:12827206). In germline cells, aberrant segregation of chromosomes is observed during both mitosis and meiosis, resulting in aneuploidy (PubMed:12827206). There is a weaker mitosis phenotype in somatic tissues (PubMed:12827206). Weak seam cell differentiation capacity during the L4 larval development stage, including 30% increased seam cell fusion and reduced cell cycle exit (PubMed:15691769). RNAi-mediated knockdown increases the survival rate and partially restores alae formation of let-7 n2853 mutants at 20 dgrees Celsius (PubMed:15691769).

6239:CELE F14B4.1
gene id: 6239:CELE_F14B4.1
uniprot id: G5EFK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE EEED8.2
gene id: 6239:CELE_EEED8.2
uniprot id: Q09529
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE T19C9.10
gene id: 6239:CELE_T19C9.10
uniprot id: D3YT90
names: Similarity
messages: Belongs to the helicase family.

6239:CELE T13F3.2
gene id: 6239:CELE_T13F3.2
uniprot id: O18086
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE M01F1.1
gene id: 6239:CELE_M01F1.1
uniprot id: G5EFK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

6239:CELE F44C8.3
gene id: 6239:CELE_F44C8.3
uniprot id: O16360
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK822.5
gene id: 6239:CELE_ZK822.5
uniprot id: Q23616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

6239:CELE C29A12.3
gene id: 6239:CELE_C29A12.3
uniprot id: Q27474
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Nucleus

6239:CELE T21C12.3
gene id: 6239:CELE_T21C12.3
uniprot id: Q22634
names: Subcellular Location Annotation
messages: Secreted

6239:CELE W06G6.3
gene id: 6239:CELE_W06G6.3
uniprot id: Q9U338
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F02A9.3
gene id: 6239:CELE_F02A9.3
uniprot id: P34383
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Probably binds lipids.
messages: Secreted

6239:CELE F49E11.7
gene id: 6239:CELE_F49E11.7
uniprot id: Q27500
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE T01G6.2
gene id: 6239:CELE_T01G6.2
uniprot id: O16968
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y105E8A.23
gene id: 6239:CELE_Y105E8A.23
uniprot id: A5PEY3
uniprot id: Q8WQA3
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6239:CELE T22B3.1
gene id: 6239:CELE_T22B3.1
uniprot id: P34807
names: Developmental Stage
names: Function
messages: Expressed predominantly in the second larval stage.
messages: May be directly or indirectly involved in cuticle function.

6239:CELE C39E6.4
gene id: 6239:CELE_C39E6.4
uniprot id: Q18533
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HMX homeobox family.
messages: Expressed in a subset of head neurons, including AIM and ASK (at protein level).
messages: First expressed around the 50-cell stage of embryogenesis in proliferating cells that are primarily located at the anterior of the embryo in the early M lineage (at protein level) (PubMed:16107479, PubMed:18316179, PubMed:22537498). During morphogenesis, expression becomes restricted to a small subset of head neuronal precursors, including AIM and ASK (at protein level) (PubMed:16107479, PubMed:18316179). Expressed in precursor cells of the left and right ventral CEPsh glia, ABplpaaapap and ABprpaaapap, respectively and also in precursors of dorsal CEPsh glia (PubMed:18508862). Expressed in the duct and pore lineages, persisting through the stages of ventral enclosure and 1.5-folds of embryonic development, but not detectable by the L1 larval stage, when duct and pore cells achieve mature morphology (PubMed:22537498, PubMed:25738873). Expressed in ABpxp descendants that give rise to the excretory system (PubMed:25738873). Transiently expressed in AWC neurons in L1 larvae until abolished shortly after hatching (PubMed:20150279). During the L2 and L3 larval stages, expressed in a group of proliferating cells surrounding the gonad (PubMed:18316179).
messages: Nucleus
messages: Transcription factor that binds to the promoter of target genes (PubMed:20150279). Regulates fate specification and/or differentiation of multiple cell types arising from the embryonic mesodermal (M) lineage and the ABp(l/r)paa precursors (PubMed:20150279, PubMed:16107479). In the postembryonic M lineage, regulates cleavage orientation, cell proliferation and cell fate specification (PubMed:16107479). Regulates hlh-1 expression to specify coelomocyte fate in the mesodermal (M) lineage (PubMed:16107479). In AWC neurons, initiates expression of ceh-36, leading to the expression of terminal differentiation genes (PubMed:20150279). Regulates ventral cephalic sheath (CEPsh) glia differentiation and expression of transcription factor hlh-17 in CEPsh glia (PubMed:18508862). Promotes terminal differentiation and morphogenesis of the epithelial duct and pore cells (PubMed:22537498). In the duct cell, cooperates with the EGF-Ras-ERK pathway in turning on the terminal differentiation gene lin-48 (PubMed:22537498).

6239:CELE F17A9.3
gene id: 6239:CELE_F17A9.3
uniprot id: O16213
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R13A1.2
gene id: 6239:CELE_R13A1.2
uniprot id: N1NV09
uniprot id: S6F510
uniprot id: S6FCX2
uniprot id: S6FWN4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F17E9.13
gene id: 6239:CELE_F17E9.13
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y56A3A.12
gene id: 6239:CELE_Y56A3A.12
uniprot id: Q9U217
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the amidase family.
messages: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:30911178). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides (PubMed:30911178). Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency (PubMed:30911178). Plays a role in the regulation of longevity and resistance to oxidative stress (PubMed:30911178).
messages: Extended lifespan, increased food consumption and increased resistance to oxidative stress induced by paraquat (PubMed:30911178). Increased levels of mono- and polyunsaturated monoacylglycerides, including endocannabinoid 2-arachidonoylglycerol (PubMed:30911178). Lifespan is further extended following treatment with the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184) (PubMed:30911178).
messages: Inhibited by the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184).

6239:CELE Y71G12B.25
gene id: 6239:CELE_Y71G12B.25
uniprot id: Q95XM8
uniprot id: W6RYA2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE VC5.2
gene id: 6239:CELE_VC5.2
uniprot id: Q9TYU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T05C1.4
gene id: 6239:CELE_T05C1.4
uniprot id: H2KY84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CAMTA family.
messages: Expressed broadly in the nervous system.
messages: May interact with calmodulin.
messages: May negatively modulate calmodulin/cmd-1 expression via a negative feedback loop in which the IQ domains bind to calmodulin.
messages: Nucleus
messages: Transcription factor (PubMed:34499028). Positively modulates neuronal levels of the ubiquitous Ca2+ sensor calmodulin/cmd-1, probably by direct binding to the cmd-1 promoter, thereby regulating Ca2+ signaling, physiology, and behavior (PubMed:34499028).

6239:CELE F32E10.2
gene id: 6239:CELE_F32E10.2
uniprot id: Q19972
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromatin anchor protein which binds to methylated lysine residues on histone H3, thereby recruiting heterochromatin to the nuclear periphery, especially in embryonic cells, with a lesser role in differentiated cells (PubMed:26607792, PubMed:31118512). May be required for the correct positioning of chromatin and nucleoli in embryos (PubMed:26607792).
messages: Expressed at all developmental stages from embryogenesis to adulthood. Evenly expressed in most tissues during the L1 stage of larval development, however, expression is weak in the intestine and high in muscle.
messages: Interacts with mono-, di- and tri-methylated 'Lys-9' residues on histone H3. Weakly interacts with methylated 'Lys-37' residues on histone H3.
messages: Membrane
messages: Nucleus inner membrane
messages: Reduced anchoring of heterochromatin to the nuclear periphery which is exacerbated on an mrg-1 mutant background and is partially blocked by RNAi-mediated knockdown of cbp-1 or atf-8 (PubMed:26607792, PubMed:31118512). Altered nucleolar localization with nucleoli positioned away from the nuclear periphery (PubMed:26607792). When exposed to hlh-1, a transcription factor that induces muscle differentiation, 25% of embryos continue to develop and the embryonic cells do not transdifferentiate into muscle-like cells like their wild-type counterparts (PubMed:26607792).

6239:CELE F43E2.4
gene id: 6239:CELE_F43E2.4
uniprot id: O02086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

6239:CELE Y48G1BM.1
gene id: 6239:CELE_Y48G1BM.1
uniprot id: Q965U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE K08F11.4
gene id: 6239:CELE_K08F11.4
uniprot id: H2KZL6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE M03C11.8
gene id: 6239:CELE_M03C11.8
uniprot id: G5EDG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).
messages: Nucleus

6239:CELE C50C3.6
gene id: 6239:CELE_C50C3.6
uniprot id: P34369
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Contains a region with structural similarity to RNase H, but lacks RNase H activity.
messages: Contains a region with structural similarity to reverse transcripase, presenting the classical thumb, fingers and palm architecture, but lacks enzyme activity, since the essential metal-binding residues are not conserved.
messages: Contains a region with structural similarity to type-2 restriction endonucleases, but the residues that would bind catalytic metal ions in endonucleases are instead involved in hydrogen bonds that stabilize the protein structure.
messages: Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
messages: Nucleus
messages: Part of the U5 snRNP complex and of the U4/U6-U5 tri-snRNP complex.
messages: The MPN (JAB/Mov34) domain has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion.

6239:CELE C50H11.15
gene id: 6239:CELE_C50H11.15
uniprot id: O16482
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C10E2.3
gene id: 6239:CELE_C10E2.3
uniprot id: O17323
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Expressed in body-wall muscle cells, hypodermal seam cells and neuronal cells including sensory amphid neuronal processes, the nerve ring, ventral nerve cords and motor neuronal commissures.
messages: Interacts with mef-2.
messages: Nucleus
messages: Phosphorylated by serine/threonine-protein kinase kin-29 at Ser-251; the phosphorylation inhibits repression of transcription by mef-2 (PubMed:17170704). May be phosphorylated by either cyclic-AMP dependent or cyclic-GMP dependent protein kinases (PubMed:18832350).
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in transduction of sensory signals, together with egl-4, kin-29 and mef-2; binding to transcription factor mef-2 enables negative modulation of chemoreceptor gene expression in chemosensory neurons (PubMed:17170704, PubMed:18832350). May be involved in muscle development (By similarity).

6239:CELE F29D10.4
gene id: 6239:CELE_F29D10.4
uniprot id: Q19901
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE T12F5.3
gene id: 6239:CELE_T12F5.3
uniprot id: O76743
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
messages: During germline proliferation.
messages: Interacts (via C-terminus) with kgb-1.
messages: Knockout with RNAi-mediated knockdown of glh-1 results in smaller P-granules and irregular cytoplasmic localization of the P-granule component pgl-3 in embryos (PubMed:21402787). Quadruple RNAi-mediated knockdown with glh-1, pgl-1 and pgl-3 results in offspring that display 27-89% sterility, abnormal oocytes and do not have embryos in the uterus (PubMed:24746798). These sterile offspring still produce sperm (PubMed:24746798). Furthermore, these offspring may have compromised P-granule integrity as there is diffuse cytoplasmic localization of the P-granule component deps-1, which may cause germ cells to initiate somatic reprogramming (PubMed:24746798). RNAi-mediated knockdown in a double ced-1 and hpl-2 mutant background rescues the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246).
messages: Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos (PubMed:21402787, PubMed:24746798). May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246).

6239:CELE B0244.5
gene id: 6239:CELE_B0244.5
uniprot id: Q10909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. B0244 subfamily.
messages: Cell membrane

6239:CELE R09F10.1
gene id: 6239:CELE_R09F10.1
uniprot id: Q23030
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE E03H4.6
gene id: 6239:CELE_E03H4.6
uniprot id: O17748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C13C12.1
gene id: 6239:CELE_C13C12.1
uniprot id: P04630
names: Function
names: Similarity
messages: Belongs to the calmodulin family.
messages: This protein resembles calmodulin in sequence but possibly resembles troponin C in function.

6239:CELE R07G3.6
gene id: 6239:CELE_R07G3.6
uniprot id: Q09423
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during larval development and strongly down-regulated in adults.
messages: Expressed in the hypodermal syncitium but not in hypodermal seam cells.
messages: Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23.
messages: Normal physiological responses to hypertonic stress, such as accumulation of organic osmolytes and activation of osmoresponsive genes, are constitutively activated with mutants exhibiting resistance to normally lethal levels of hypertonic stress.
messages: Secreted

6239:CELE E01G6.3
gene id: 6239:CELE_E01G6.3
uniprot id: G5EC03
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C49G7.3
gene id: 6239:CELE_C49G7.3
uniprot id: O16226
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F41C3.2
gene id: 6239:CELE_F41C3.2
uniprot id: Q20265
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08F1.7
gene id: 6239:CELE_F08F1.7
uniprot id: O17388
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

6239:CELE B0348.2
gene id: 6239:CELE_B0348.2
uniprot id: O61958
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE C24H12.4
gene id: 6239:CELE_C24H12.4
uniprot id: A0A0K3AQY8
uniprot id: O17157
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

6239:CELE C10C6.2
gene id: 6239:CELE_C10C6.2
uniprot id: P90745
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F28C6.7
gene id: 6239:CELE_F28C6.7
uniprot id: Q19869
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

6239:CELE C40C9.5
gene id: 6239:CELE_C40C9.5
uniprot id: Q9XTG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Interacts (via extracellular domain) with isoform b of madd-4; the interaction is required for the localization to postsynaptic domains (PubMed:26028575, PubMed:26028574). Interacts with unc-49 (PubMed:26028575).
messages: Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission (PubMed:26028574, PubMed:26028575).
messages: Synapse
messages: The cytoplasmic region is required for GABA(A) receptor clustering.
messages: The extracellular region is required for the localization to synapses and for GABA(A) receptor clustering.

6239:CELE F58A6.11
gene id: 6239:CELE_F58A6.11
uniprot id: Q20963
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed in the head sensory neurons ASI, ASK and AWB (PubMed:28662030). Not expressed in male somatic gonads or sperm (PubMed:28662030).
messages: Expressed throughout larval development and adulthood.
messages: G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis (PubMed:28662030). This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages (PubMed:28662030). Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030). May act in the same signaling pathway as the neuropeptide flp-21 (PubMed:28662030).
messages: Perikaryon
messages: Reduced brood size, which is in part due to an abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm reversing course frequently and accumulating at the spermathecal-uterine valve 1 hour following mating (PubMed:28662030). No visible defects in oogenesis (PubMed:28662030). Double knockout with the mcu-1 ju1154 mutant suppresses the sperm navigation defect in the srb-13 single mutant (PubMed:28662030).
messages: dendrite

6239:CELE F28C6.3
gene id: 6239:CELE_F28C6.3
uniprot id: Q19864
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F42G4.3
gene id: 6239:CELE_F42G4.3
uniprot id: Q9U3F4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Expressed in neurons and body wall muscle (PubMed:18094057, PubMed:23427270, PubMed:25252943). Expressed in pharyngeal, enteric and uterine muscles and in spermatheca (PubMed:25252943).
messages: Expressed in neurons and muscle throughout development.
messages: Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus) (PubMed:23427270). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development (PubMed:25252943).
messages: Interacts with dyc-1 (PubMed:18094057, PubMed:23427270). Interacts with glh-1 and glh-3 (PubMed:12435362).
messages: M line
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform a.
messages: RNAi-mediated knock-down of isoform a in a dys-1/hlh-1 double mutant background reduces muscle degeneration.
messages: The LIM domains are sufficient for the role in PLM synaptogenesis.
messages: axon
messages: cytoskeleton
messages: focal adhesion

6239:CELE F28G4.1
gene id: 6239:CELE_F28G4.1
uniprot id: O17851
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE M18.2
gene id: 6239:CELE_M18.2
uniprot id: Q21557
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6239:CELE M01B2.2
gene id: 6239:CELE_M01B2.2
uniprot id: O17956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y48A6B.5
gene id: 6239:CELE_Y48A6B.5
uniprot id: Q9XXD2
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the RNA exosome complex.
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (Probable). Involved in regulation of antisense ribosomal siRNA production (PubMed:34365510). Involved in response to cold-warm shock (PubMed:36763670).
messages: Nucleus
messages: Ubiquitously expressed.
messages: nucleolus
messages: nucleoplasm

6239:CELE F54E7.2
gene id: 6239:CELE_F54E7.2
uniprot id: P49196
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Subunit of the 40S ribosomal complex (By similarity).
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity). Involved in cold-warm shock-induced translocation of the RNA exosome components from the nucleolus to nucleoplasm (PubMed:36763670).
messages: nucleolus

6239:CELE C54F6.14
gene id: 6239:CELE_C54F6.14
uniprot id: O16453
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6239:CELE K06C4.11
gene id: 6239:CELE_K06C4.11
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F17A9.6
gene id: 6239:CELE_F17A9.6
uniprot id: O16218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

6239:CELE F10B5.8
gene id: 6239:CELE_F10B5.8
uniprot id: Q9U3K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

6239:CELE C45E5.6
gene id: 6239:CELE_C45E5.6
uniprot id: H2KZB8
uniprot id: Q95QR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y69A2AR.18
gene id: 6239:CELE_Y69A2AR.18
uniprot id: Q95XJ0
names: Similarity
messages: Belongs to the ATPase gamma chain family.

6239:CELE ZK669.3
gene id: 6239:CELE_ZK669.3
uniprot id: Q23570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Secreted

6239:CELE F17E5.1
gene id: 6239:CELE_F17E5.1
uniprot id: P54936
names: Function
names: Similarity
messages: Belongs to the MAGUK family.
messages: May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.

6239:CELE F37C12.7
gene id: 6239:CELE_F37C12.7
uniprot id: Q20121
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F59F4.1
gene id: 6239:CELE_F59F4.1
uniprot id: Q93839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

6239:CELE F33D4.1
gene id: 6239:CELE_F33D4.1
uniprot id: Q9XYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y105E8A.3
gene id: 6239:CELE_Y105E8A.3
uniprot id: Q8WQB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE T14G8.1
gene id: 6239:CELE_T14G8.1
uniprot id: Q22516
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.
messages: Detected around the 20 cell stage after the onset of zygotic transcription. Also expressed in adults.
messages: Expressed in the head and vulva.
messages: Nucleus

6239:CELE F57A8.2
gene id: 6239:CELE_F57A8.2
uniprot id: Q20913
uniprot id: Q2PJ77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

6239:CELE Y105C5B.21
gene id: 6239:CELE_Y105C5B.21
uniprot id: A0A078BPM1
uniprot id: A0A078BPN7
uniprot id: A0A078BQQ1
uniprot id: A0A078BS85
uniprot id: D3DEL7
uniprot id: D3DEL8
uniprot id: Q9U308
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associated with the catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2 (PubMed:25938815). Interacts with hmr-1 (PubMed:12847081, PubMed:25938815). Interacts with picc-1 (PubMed:25938815).
messages: Belongs to the beta-catenin family.
messages: Embryos are viable, but display a partial loss of junctional component, pac-1, from adherens junctions.
messages: Epidermal cells.
messages: Expressed in the early epidermis.
messages: May act as a positive modulator of hmr-1 function during epidermal morphogenesis (PubMed:12847081). Required for proper localization of other junctional components, such as pac-1 (PubMed:25938815).
messages: Nucleus
messages: adherens junction

6239:CELE Y57G11C.16
gene id: 6239:CELE_Y57G11C.16
uniprot id: O18240
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

6239:CELE T05H4.4
gene id: 6239:CELE_T05H4.4
uniprot id: O16522
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

6239:CELE F41E6.9
gene id: 6239:CELE_F41E6.9
uniprot id: O16458
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE F52B11.2
gene id: 6239:CELE_F52B11.2
uniprot id: Q9XUE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

6239:CELE Y69A2AR.3
gene id: 6239:CELE_Y69A2AR.3
uniprot id: Q95XG6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

6239:CELE C34C6.8
gene id: 6239:CELE_C34C6.8
uniprot id: P20270
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K02B2.1
gene id: 6239:CELE_K02B2.1
uniprot id: Q21122
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.

6239:CELE R07E5.8
gene id: 6239:CELE_R07E5.8
uniprot id: Q21829
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

6239:CELE W07E11.1
gene id: 6239:CELE_W07E11.1
uniprot id: K8F7V7
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

6239:CELE T03F6.6
gene id: 6239:CELE_T03F6.6
uniprot id: Q8WQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE C55C3.4
gene id: 6239:CELE_C55C3.4
uniprot id: Q18865
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y79H2A.6
gene id: 6239:CELE_Y79H2A.6
uniprot id: Q9U1R7
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

6239:CELE Y49E10.4
gene id: 6239:CELE_Y49E10.4
uniprot id: Q9XTU8
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

6239:CELE F29C4.2
gene id: 6239:CELE_F29C4.2
uniprot id: O76367
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6c family.

6239:CELE K02E11.2
gene id: 6239:CELE_K02E11.2
uniprot id: Q21142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE W03G1.6
gene id: 6239:CELE_W03G1.6
uniprot id: U4PR86
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: During neuroblast differentiation, mutants produce an additional precursor cell for the HSN/PHB, I2, M4 and PLM/ALN and Q.a and Q.p lineages. The nucleus size of the 2 Q.p daughter cells is similar (PubMed:16774992). Symmetrical distribution of myosin II during QR.a cell division (PubMed:20929735). Abnormally high number of ADE neurons (PubMed:28659600). Double knockouts of pig-1 and ced-3 have impaired cell shedding during embryogenesis which results in the generation of an ectopic excretory cell and an ERM-like neuron. In addition, mutants show a delay in clearance after engulfment of cell corpses which is associated with the abnormal expression of cell adhesion molecules (PubMed:22801495).
messages: May be phosphorylated at Thr-169 by par-4 and/or autophosphorylated which likely results in its activation (PubMed:22801495). Phosphorylation is not required for co-localization with the centrosome (PubMed:23267054).
messages: Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants (PubMed:16774992, PubMed:20929735, PubMed:23946438, PubMed:23267054, PubMed:23851392, PubMed:28659600). Plays a role in neural fate specification in several dopaminergic linages, acting in concert with ham-1 (PubMed:28659600). Involved in phosphorylation of multiple proteins associated with key developmental processes, including the cell cycle, apoptosis, endocytosis, and asymmetric cell division (PubMed:28659600). Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface (PubMed:22801495). May act downstream of par-4/strd-1/mop-25 to regulate cell shedding (PubMed:22801495).
messages: The KA1 domain is required for the control of asymmetric neuroblast division.
messages: Ubiquitously expressed in early embryo with a more restricted expression in later embryonic stages and in young larvae. Expressed in dividing cells including ventral nerve cord neuroblasts, vulval precursors, hypodermal seam cells and in the Q lineage. No expression in adults.
messages: centrosome

6239:CELE F08C6.3
gene id: 6239:CELE_F08C6.3
uniprot id: G5EFV8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843).
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-53 and vps-54 (PubMed:21613545). Interacts with the small GTPases rab-6.1 and rab-6.2 (PubMed:21613545).
messages: Enlarged lysosomes (PubMed:21613545). Reduced brood size (PubMed:21613545). Egg-laying defect, slow, but coordinated locomotion, and reduced levels of unprocessed and processed cargo in the motor neuron axon of the dorsal nerve cord (PubMed:27191843).
messages: Perikaryon
messages: Ubiquitously expressed, with particularly strong expression in neuronal cells (PubMed:21613545). Specifically expressed in head and tail neurons and in the pharynx and ventral cord motor neurons (PubMed:27191843).
messages: perinuclear region
messages: trans-Golgi network

6239:CELE R07D5.1
gene id: 6239:CELE_R07D5.1
uniprot id: C8JQR7
uniprot id: Q03412
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Heterooligomer of unc-7 and unc-9.
messages: In hermaphrodites, expressed in all premotor and motor neurons, and in tail neurons (PubMed:26156999). In males, expressed in the anal depressor, gubernacular erector, gubernacular retractor and anterior oblique muscles, SPC, PCA, PCB, HOA, ray, head ganglion and ventral cord neurons (PubMed:26156999).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in all developmental stages but most abundant in L1-L3 larvae.
messages: Restores pharyngeal pumping but not impaired locomotion in 33 percent of animals overexpressing lin-3.
messages: Structural component of the gap junctions (By similarity). Required for coordinated locomotion (PubMed:7681023). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142). Plays a role in regulating male mating behavior by positively regulating inhibitory neuronal signaling transduction between chemosensory and mechanosensory neurons, and thus ensuring spicule insertion attempts are confined to the hermaphrodite vulva during copulation (PubMed:26156999).
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE W01A8.4
gene id: 6239:CELE_W01A8.4
uniprot id: Q23098
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.

6239:CELE F56B3.7
gene id: 6239:CELE_F56B3.7
uniprot id: O45109
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K09A9.4
gene id: 6239:CELE_K09A9.4
uniprot id: Q93875
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE F42A9.4
gene id: 6239:CELE_F42A9.4
uniprot id: Q20315
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y51H4A.4
gene id: 6239:CELE_Y51H4A.4
uniprot id: Q9NAE4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F56B3.6
gene id: 6239:CELE_F56B3.6
uniprot id: O45108
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE F35F10.7
gene id: 6239:CELE_F35F10.7
uniprot id: Q9GYU2
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE W02B12.15
gene id: 6239:CELE_W02B12.15
uniprot id: A7LPG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane

6239:CELE D1044.2
gene id: 6239:CELE_D1044.2
uniprot id: P41950
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development (PubMed:19344940). Promotes seam cell remodeling during the dauer phase (PubMed:30409788). Plays a role in positively regulating locomotion during the dauer phase (PubMed:30409788).
messages: Expression is first apparent in bean-stage embryos, peaks in late embryogenesis, reduces in L1 larvae and is negligible in later larval stages and adults (PubMed:19344940). In the embryo, expressed in the excretory cell and, during dendrite formation, in the non-neuronal cells surrounding the sensory neurons, including hypodermal cells (PubMed:19344940). Expressed in pharyngeal cells throughout the larval stages (PubMed:30409788). Expression in the seam cells and glia socket cells of the anterior and posterior deirid neurons begins at the L2 pre-dauer stage and persists throughout the dauer phase (PubMed:30409788). During the dauer phase expressed along the length of the animal above seam cells, alternating between alae under the outer ridges and below the lateral ridge (PubMed:30409788).
messages: May be proteolytically cleaved and secreted.
messages: Membrane
messages: Secreted
messages: dendrite

6239:CELE F59B10.4
gene id: 6239:CELE_F59B10.4
uniprot id: Q09952
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C50C3.2
gene id: 6239:CELE_C50C3.2
uniprot id: P34367
names: Similarity
messages: Belongs to the spectrin family.

6239:CELE F25B5.6
gene id: 6239:CELE_F25B5.6
uniprot id: Q09509
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Produced by alternative initiation at Met-27 of isoform a.
messages: Produced by alternative splicing.

6239:CELE B0361.5
gene id: 6239:CELE_B0361.5
uniprot id: Q10949
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

6239:CELE C14B1.8
gene id: 6239:CELE_C14B1.8
uniprot id: Q17964
names: Similarity
messages: Belongs to the SIKE family.

6239:CELE K01G5.8
gene id: 6239:CELE_K01G5.8
uniprot id: G5ECC8
names: Similarity
messages: Belongs to the FAM32 family.

6239:CELE F31D4.4
gene id: 6239:CELE_F31D4.4
uniprot id: O45419
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y32F6A.5
gene id: 6239:CELE_Y32F6A.5
uniprot id: G5EDP0
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE R12E2.9
gene id: 6239:CELE_R12E2.9
uniprot id: O61786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE Y37A1B.13
gene id: 6239:CELE_Y37A1B.13
uniprot id: Q9XXG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

6239:CELE C36B1.3
gene id: 6239:CELE_C36B1.3
uniprot id: Q93338
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

6239:CELE ZK370.8
gene id: 6239:CELE_ZK370.8
uniprot id: Q02335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tom70 family.
messages: Expressed in body wall muscle cells, the pharynx and structures in the tail.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane
messages: Receptor that accelerates the import of all mitochondrial precursor proteins.

6239:CELE W08E3.1
gene id: 6239:CELE_W08E3.1
uniprot id: P91918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: cytosol

6239:CELE Y56A3A.19
gene id: 6239:CELE_Y56A3A.19
uniprot id: Q9U241
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

6239:CELE B0393.7
gene id: 6239:CELE_B0393.7
uniprot id: Q17496
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C17C3.12
gene id: 6239:CELE_C17C3.12
uniprot id: H2KYT9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE D2030.4
gene id: 6239:CELE_D2030.4
uniprot id: P90789
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

6239:CELE R05G9.2
gene id: 6239:CELE_R05G9.2
uniprot id: Q65XY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y40H7A.8
gene id: 6239:CELE_Y40H7A.8
uniprot id: G5EBT4
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R144.9
gene id: 6239:CELE_R144.9
uniprot id: Q9BI74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE C04F5.1
gene id: 6239:CELE_C04F5.1
uniprot id: Q9GZC8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Absence of silencing in adjacent cells or tissues. Decrease in transgene silencing when combined with eri-1.
messages: Belongs to the SID1 family.
messages: Cell membrane
messages: Expressed in most non-neuronal cells, including body wall muscle cells.
messages: Expressed throughout all developmental stages.
messages: May self-associate to form multimers.
messages: Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent (PubMed:26067272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307).
messages: This avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never been exposed to this pathogenic bacteria.

6239:CELE T07A9.2
gene id: 6239:CELE_T07A9.2
uniprot id: O44413
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

6239:CELE C01G10.11
gene id: 6239:CELE_C01G10.11
uniprot id: E0AHC3
uniprot id: E0AHC4
uniprot id: E0AHC5
uniprot id: E0AHC6
uniprot id: Q7JL61
uniprot id: Q7JL62
names: Similarity
messages: Belongs to the zygin family.

6239:CELE F41B4.3
gene id: 6239:CELE_F41B4.3
uniprot id: Q966J4
names: Similarity
messages: Belongs to the C19orf12 family.

6239:CELE K08B4.4
gene id: 6239:CELE_K08B4.4
uniprot id: Q9TYY4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W05B2.6
gene id: 6239:CELE_W05B2.6
uniprot id: Q9XVG3
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F38A6.1
gene id: 6239:CELE_F38A6.1
uniprot id: Q17381
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcription factor required for formation of the pharyngeal primordium (PubMed:7607089, PubMed:18448117). Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression (PubMed:18448117). Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription (PubMed:20714352). Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1 (PubMed:20714352). Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate (PubMed:11823633, PubMed:20714352, PubMed:9584117, PubMed:14738885). Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3 (PubMed:17476212). Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland (PubMed:17049341). May regulate gene expression in the intestine (PubMed:18448117).
messages: Expression first seen at the 8E cell stage in the embryonic gut. After hatching, expression is almost diminished in the pharynx and gut. Expressed in L3/L4 larvae in cells of the developing gonad. At the 8-12E stage, expression is seen for the first time in the rectal precursors. Intestinal expression is down-regulated during the larval to adult transition.
messages: Interacts with elt-2.
messages: Nucleus
messages: Strongly expressed in the embryonic pharynx, particularly pharyngeal primordium precursor cells. Expression less strong in the embryonic gut. Expressed in adult intestine (PubMed:17113066).
messages: Worms are unable to form the pharyngeal primordium with the pharyngeal precursor cells, ABaraapapaa and ABaraapppaa showing arrested development prior to terminal cell division. Some mutants exhibit malformed rectal tissues and fail to undergo proper embryonic elongation. RNAi-mediated knockdown at the L1 larval stage reduces survival (PubMed:30965033).

6239:CELE T10C6.11
gene id: 6239:CELE_T10C6.11
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE M01D7.6
gene id: 6239:CELE_M01D7.6
uniprot id: O01971
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout the development and in adults.
messages: Interacts with lmn-1 and baf-1.
messages: Mild increase in embryonic lethality of progeny of X-ray-irradiated adults (PubMed:22383942). Slightly more spherical nuclei (PubMed:25653391). Simultaneous knockout of emr-1 and lem-2 leads to embryonic lethality, 8.5% shorter animals in larval stage L2, abnormal gonads and a developmental stop at late L2/early L3 (PubMed:22171324). Missing cell divisions in the postembryonic mesodermal lineage and failure to produce any of the differentiated M lineage cells (PubMed:22171324). Defects in the organization of chromatin, nuclear intermediate filaments, and nuclear pore complexes (NPCs), and defects in mitosis in cells that continue to divide after embryogenesis (PubMed:22171324). In the mitotic zone of the gonad, lmn-1 and NPCs are mislocalized and nuclei are misshaped (PubMed:22171324). Misshaped nuclei with large lmn-1 aggregates, clustered NPCs and condensed chromatin in somatic hypodermal cells (PubMed:22171324). Defects in motility, sarcomere organization, and muscle attachment to hypodermis (PubMed:22171324). Decreased motility and near paralysis at day 6 (PubMed:22171324). Disorganized thin and thick filaments of sarcomeres and abnormally positioned muscles at day 3 and 6 (PubMed:22171324). Decreased pumping rate of the pharynx (PubMed:22171324). RNAi-mediated knockdown causes an increase in the number of nuclei with pha-4 bound to the pax-1 promoter; observed in pharyngeal but not intestinal cells (PubMed:20714352). Simultaneous RNAi-mediated knockdown of lem-2 and emr-1 causes anaphase chromatin bridges and redistribution of baf-1 from the nuclear periphery to the segregating chromatin during anaphase (PubMed:12684533).
messages: Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis (PubMed:11870211, PubMed:12684533, PubMed:22171324). Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina (PubMed:11870211, PubMed:12684533). Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells (PubMed:22171324). Together with lem-2, plays a role in baf-1 enrichment at the nuclear envelope in anaphase (PubMed:12684533). Together with lem-2, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization (PubMed:22171324). May play a role in radiation-induced DNA damage repair response (PubMed:22383942). May repress binding of transcription factor pha-4 with target sequences in pharyngeal cells.
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Ubiquitous (PubMed:11870211, PubMed:25653391). Expressed in all cells, except in cells undergoing spermatogenesis (PubMed:11870211). High expression in hypodermis, neurons, pharyngeal muscle, body wall muscle and gonadal sheath (PubMed:25653391).

6239:CELE Y75B8A.14
gene id: 6239:CELE_Y75B8A.14
uniprot id: Q9XW68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

6239:KEF34 p08
gene id: 6239:KEF34_p08
uniprot id: P24889
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

6239:CELE T09B4.8
gene id: 6239:CELE_T09B4.8
uniprot id: O02158
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

6239:CELE K08D12.2
gene id: 6239:CELE_K08D12.2
uniprot id: Q966I6
names: Function
names: Similarity
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.

6239:CELE W06D4.1
gene id: 6239:CELE_W06D4.1
uniprot id: Q9Y041
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the homogentisate dioxygenase family.
messages: Expressed in the hypodermis and intestine.
messages: Plays a role in the tyrosine degradation pathway.
messages: RNAi-mediated knockdown together with fah-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant.

6239:CELE F08F1.5
gene id: 6239:CELE_F08F1.5
uniprot id: O17386
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Cell membrane
messages: Cleavage by ced-3 activates ced-8 function in promoting phosphatidylserine exposure at the surface of apoptotic cells.
messages: Delayed cell death process.
messages: Phospholipid scramblase that acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:24225442, PubMed:23845944). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:24225442, PubMed:23845944). Regulates apoptosis kinetics during embryonic development (PubMed:10882128, PubMed:1936965, PubMed:24225442, PubMed:23845944). Not required for engulfment of germ cell corpses (PubMed:9927601).

6239:CELE F57B9.4
gene id: 6239:CELE_F57B9.4
uniprot id: Q8I7J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

6239:CELE F33E11.6
gene id: 6239:CELE_F33E11.6
uniprot id: Q2A950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

6239:CELE B0213.16
gene id: 6239:CELE_B0213.16
uniprot id: O61204
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K08D9.3
gene id: 6239:CELE_K08D9.3
uniprot id: A0A0S4XRY4
uniprot id: P41990
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: First expressed in late 2-cell stage embryos at the anterior periphery of the P1 blastomere, where P1 contacts the AB blastomere (at protein level) (PubMed:8674418). Maternally expressed in newly fertilised eggs, and present in all blastomeres between 1-cell and 8-cell stages (PubMed:8674418). After the 8-cell stage, rapidly disappears from all somatic blastomeres, and then expressed in P3 blastomere at the 12 cell stage (PubMed:8674418). In 36-cell stage and later embryos, can be detected in one to five unidentified cells (PubMed:8674418). Expressed in the P6.p vulval precursor cell (VPC) during larval L3 stage, coinciding with extension and reflexing of the gonad (PubMed:14960273). Expressed in cells immediately adjacent to ventral mesodermal lineage (M lineage) cells, but not next to dorsal M lineage cells, beginning at the 4-M stage (PubMed:18036582). Expressed in the distal tip cell (DTC) starting in the larval L3 stage (PubMed:19502484). Expressed in the secondary vulval epithelial cells and the non-target vm1 cells at the larval L4 stage (PubMed:23539368).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling (PubMed:14960273, PubMed:7568229, PubMed:8575327). Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with dsl-1 and lag-2 (PubMed:14960273, PubMed:7568229). Contributes to the establishment of the dorsal-ventral axis in early embryos (PubMed:8156602, PubMed:18036582). Involved in the specification of the blastomere cell ABp fate, probably acting as a signal from the P2 blastomere to the glp-1/Notch receptor on ABp and ABa (PubMed:8156602, PubMed:7925031, PubMed:8674418). Probably acts as a signal, from the secondary vulval epithelial cells and the vulval muscle type 1 (vm1) cells, to activate the lin-12/Notch pathway in type 2 vulval muscle (vm2) cells, contributing to formation of the postsynaptic muscle plasma membrane extensions, known as muscle arms (PubMed:23539368). Required for oocyte growth control, acting redundantly with lag-2, perhaps signaling via the glp-1/Notch pathway (PubMed:19502484). Plays a somatic role in ovulation during adulthood, perhaps via lin-12/Notch signaling (PubMed:29371032). Involved in establishing left-right asymmetry during intestinal organogenesis (PubMed:10903169).
messages: RNAi-mediated knockdown in the L1 larval stage causes an endomitotic oocyte phenotype; effect not seen if knockdown is targeted to germline, rather than somatic cells (PubMed:29371032). RNAi-mediated knockdown alters ovulation (PubMed:29371032). Spermatheca calcium flux is altered by RNAi-mediated knockdown (PubMed:29371032). RNAi-mediated knockdown, on a lag-2 mutant background, induces the presence of 1-2 extra mesodermal lineage (M lineage)-derived coelomocytes (PubMed:18036582). RNAi-mediated knockdown on a lin-15 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate (PubMed:14960273). On a lag-2 mutant background, RNAi-mediated knockdown causes germ cells to display nuclear morphology consistent with meiotic prophase or gametogenesis in adult hermaphrodites (PubMed:19502484). RNAi-mediated knockdown, when combined with RNAi-mediated knockdown of lag-2, on a dsl-1 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated on double mutant lin-15;dsl-1 background (PubMed:14960273).

6239:CELE T26C12.4
gene id: 6239:CELE_T26C12.4
uniprot id: G5EEE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed specifically in AFD sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium

6239:CELE Y106G6A.5
gene id: 6239:CELE_Y106G6A.5
uniprot id: Q9XWQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dysbindin family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1. Interacts with snpn-1.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE ZK662.4
gene id: 6239:CELE_ZK662.4
uniprot id: Q27395
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class A protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:8054684). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514).
messages: Synthetic multivulva (synMuv) class B protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684, PubMed:11463372). Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development (PubMed:8054684). Regulates let-23 basal activity (PubMed:8054684).
messages: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.

6239:CELE K07A12.7
gene id: 6239:CELE_K07A12.7
uniprot id: Q9NAP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE C23H3.4
gene id: 6239:CELE_C23H3.4
uniprot id: P91079
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.
messages: Heterodimer of sptl-1/sptl-2 or sptl-1/sptl-3.

6239:CELE R11A8.4
gene id: 6239:CELE_R11A8.4
uniprot id: Q21921
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Expressed in neurons of the head and tail from embryo to adult. Expressed in the hypodermis from the three-fold stage of embryogenesis; expression in the hypodermis subsequently decreases at L3 and is undetectable in adults.
messages: Interacts with ftt-2 and par-5 (PubMed:16777605). Interacts with daf-16 following heat-shock, which causes daf-16 to accumulate in the nucleus (PubMed:16777605). Interaction with daf-16 is promoted by ftt-2 (PubMed:16777605). Interacts with transcriptional coregulator hcf-1 (PubMed:21909281).
messages: NAD-dependent deacetylase (By similarity). Involved in metabolism, apoptosis, response to oxidative stress, response to DNA damage, and determination of lifespan (PubMed:16777605, PubMed:16280150, PubMed:16256736, PubMed:21909281, PubMed:23509272, PubMed:24077178, PubMed:27514077, PubMed:26598553, PubMed:27650246). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255). Plays a role in germ cell and somatic cell apoptosis in response to DNA damage (PubMed:26598553, PubMed:27650246). Functions upstream of daf-16/Forkhead box protein O in the Insulin/IGF-1-like signaling (IIS) mediated pathway, promoting daf-16 mediated transcriptional activation and increased lifespan (PubMed:16777605, PubMed:16280150). May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER) (PubMed:16256736, PubMed:16280150). Functions upstream of transcriptional coregulator hcf-1, perhaps acting independently of the IIS mediated pathway, to modulate lifespan and oxidative stress response (PubMed:21909281). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity (PubMed:24077178). Plays a role in ascaroside-mediated longevity and stress resistance (PubMed:23509272).
messages: Nucleus
messages: Reduces the longevity-extending effects of nicotinic acid when exposed to 1 mM nicotinic acid (PubMed:24077178). Defective ascaroside-mediated responses with neither ascr#2 nor ascr#3 inducing lifespan extension or conferring thermotolerance (PubMed:23509272). Reduced germ cell apoptosis in the gonadal arms following DNA damage induced by UV-irradiation (PubMed:26598553). RNAi-mediated depletion results in an increase of 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255).

6239:CELE R186.7
gene id: 6239:CELE_R186.7
uniprot id: Q95ZQ5
names: Similarity
messages: Belongs to the pinin family.

6239:CELE M176.6
gene id: 6239:CELE_M176.6
uniprot id: P34891
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed during hypodermal development.
messages: Hypodermal cells.
messages: May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.

6239:CELE F32B6.6
gene id: 6239:CELE_F32B6.6
uniprot id: Q9TVW5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C18C4.1
gene id: 6239:CELE_C18C4.1
uniprot id: A3RMS5
names: Similarity
messages: Belongs to the globin family.

6239:CELE K07G5.2
gene id: 6239:CELE_K07G5.2
uniprot id: Q21302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

6239:CELE T22F3.8
gene id: 6239:CELE_T22F3.8
uniprot id: Q94305
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T23G11.2
gene id: 6239:CELE_T23G11.2
uniprot id: G5EC27
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

6239:CELE Y34D9A.6
gene id: 6239:CELE_Y34D9A.6
uniprot id: Q9N456
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

6239:CELE Y41D4B.9
gene id: 6239:CELE_Y41D4B.9
uniprot id: Q95Y09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE D2013.10
gene id: 6239:CELE_D2013.10
uniprot id: O62126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

6239:CELE Y52B11A.2
gene id: 6239:CELE_Y52B11A.2
uniprot id: Q9XWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPACT family.
messages: Cytoplasm
messages: Interacts with gcn-1; prevents the interaction of gcn-1 with gcn-2 and inhibits gcn-2 kinase activity. Interaction with rpl-39; this interaction occurs in a gcn-1-independent manner. Associates with ribosomes; this interaction occurs in a gcn-1-independent manner. Associates with actin; this interaction occurs in a gcn-1-independent manner.
messages: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.

6239:CELE F17C8.2
gene id: 6239:CELE_F17C8.2
uniprot id: Q19528
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C13C4.6
gene id: 6239:CELE_C13C4.6
uniprot id: O01928
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T10C6.12
gene id: 6239:CELE_T10C6.12
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C01G8.2
gene id: 6239:CELE_C01G8.2
uniprot id: G5ECU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

6239:CELE C49D10.9
gene id: 6239:CELE_C49D10.9
uniprot id: O16603
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C55B7.8
gene id: 6239:CELE_C55B7.8
uniprot id: Q966M6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Active in presence of diverse metals including Fe(2+), Zn(2+), Mn(2+) (By similarity). Binds two metal cations in two adjacent alpha and beta metal-binding pockets (By similarity).
messages: Belongs to the lariat debranching enzyme family.
messages: Binds 2 divalent metal cations per subunit.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover.
messages: Nucleus

6239:CELE D2024.7
gene id: 6239:CELE_D2024.7
uniprot id: Q18973
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GST superfamily. Kappa family.
messages: Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine.
messages: Has roles in respiratory and lipid metabolism.
messages: Mitochondrion
messages: Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid.

6239:CELE F10C2.7
gene id: 6239:CELE_F10C2.7
uniprot id: P90832
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T07H8.4
gene id: 6239:CELE_T07H8.4
uniprot id: H2KZ68
uniprot id: Q5ZR39
uniprot id: Q5ZR42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T06D8.9
gene id: 6239:CELE_T06D8.9
uniprot id: Q22254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y69A2AR.31
gene id: 6239:CELE_Y69A2AR.31
uniprot id: Q95XG5
names: Similarity
messages: Belongs to the GDNFR family.

6239:CELE Y55F3AM.8
gene id: 6239:CELE_Y55F3AM.8
uniprot id: Q9N371
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE T09A5.9
gene id: 6239:CELE_T09A5.9
uniprot id: P45969
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS22 family.
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1.

6239:CELE F40E10.3
gene id: 6239:CELE_F40E10.3
uniprot id: Q20203
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

6239:CELE T05C12.6
gene id: 6239:CELE_T05C12.6
uniprot id: Q22227
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSH family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Embryonic and larval cell fate, polarity, division and migration defects (PubMed:16899238, PubMed:17196955, PubMed:26795562). In several lineages of the developing gonad 42.6% of hermaphrodites do not have either one or both distal tip cells, which results in the absence of the corresponding gonad arm, and germline proliferation defects in the male germ line (PubMed:16899238). Defects in hypodermal morphogenesis including disorganized dorsal cell intercalation, eventually resulting in 2-fold stage arrest, and failed ventral enclosure in some worms (PubMed:16899238). Cell polarity and migration defects including mitotic spindle misalignment, particularly in the ABar blastomere which results in the posterior cells of the blastomere adopting an alternate more anterior position (PubMed:16899238). Defective QL neuroblast migration with 100% of descendants migrating towards the anterior rather than the posterior of larvae (PubMed:16899238). Disrupted asymmetric cell divisions of hypodermal seam cells with the mislocalization and reduced expression of a wnt/beta catenin pathway component sys-1 and its negative regulator apr-1, and wrm-1 in daughter seam cells (PubMed:26795562). Irregular symmetric localization of lin-17/Frizzled in ectodermal blast B cells (PubMed:17196955).
messages: Expressed throughout embryonic and larval development (PubMed:16899238). Expressed in most embryonic cells during hypodermal morphogenesis, and in Z1 and Z4 distal tip precursor cells, in distal tips cells during gonadal migration and in the gonandal primordium, which become vulval precursor cells, during larval development (PubMed:16899238). Also expressed in hypodermal precursor cells P11 and P12 and their daughter cells P11.a, P11.p, P12.a and P12.p, and in the SDQL and PVM neurons which are derived from the QL neuroblast (PubMed:16899238). During larval development, expressed in blast B cells and its descendants, the QL cell and in cells in the nerve ring (PubMed:16631156).
messages: Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:26795562). Functions redundantly with other dishevelled family members throughout development (PubMed:19298786, PubMed:25344071, PubMed:26460008, PubMed:26795562). During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells (PubMed:16899238, PubMed:26795562). In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the correct mitotic spindle orientation of the ABar blastomere division plane (PubMed:16899238, PubMed:25344071). Controls the polarity and the asymmetric localization of downstream components of the wnt/beta-catenin asymmetry pathway, and in particular, controls the asymmetric localization of the wnt receptor lin-17/Frizzled in ectodermal blast B cells (PubMed:16631156, PubMed:17196955, PubMed:19298786, PubMed:26795562). May act redundantly with dsh-2 to regulate the expression and nuclear localization of the beta-catenin homolog wrm-2, but alone seems to be required for the polarity of wrm-2 during the asymmetric cell division of hypodermal seam cells (PubMed:26795562). Also, maintains the polarity and migration of QL neuroblasts in larvae (PubMed:16899238). During the embryonic development of touch receptor neurons, may act redundantly with dsh-1, downstream of wnt signaling ligands and the wnt receptor lin-17/Frizzled, to direct the growth of neurites of touch receptor neurons towards the anterior of the body of the worm and towards the PLM touch receptor neuron and other tail neurons (PubMed:26460008). May play a role in the guidance of posterior D-type motor neuron axons along the anteroposterior axis (PubMed:19259273).
messages: The DEP domain is required for cell membrane localization.
messages: cell cortex

6239:CELE F32D1.10
gene id: 6239:CELE_F32D1.10
uniprot id: O16297
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

6239:CELE F32B4.2
gene id: 6239:CELE_F32B4.2
uniprot id: O62204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane

6239:CELE C47A10.5
gene id: 6239:CELE_C47A10.5
uniprot id: O45307
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Expressed in the intestinal cells, hypodermis and in unidentified cells in the head in adult hermaphrodites.
messages: Expression detected in the intestinal cells from 3-fold stage embryo to adult stages, and also in the hypodermis and in unidentified cells in the head from larval to adult stages.
messages: Mutant worms have decreased egg-laying capacity at 20 degrees Celsius and decreased hatching rate and smaller brood size at 25 degrees Celsius. Mutant worms have high D-Asp and D-Glu content at both egg and young adult stage but do not show any change in physical appearance. Mutant worms also exhibit decreased fertilization rates.
messages: Peroxisome
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells.

6239:CELE K08C7.2
gene id: 6239:CELE_K08C7.2
uniprot id: G5EDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE C28D4.3
gene id: 6239:CELE_C28D4.3
uniprot id: O02225
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE B0244.2
gene id: 6239:CELE_B0244.2
uniprot id: G5EGJ5
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Expressed at all stages including the dauer stage. Expression in the ventral cord and near the vulva starts at the L4 larval stage.
messages: In hermaphrodites specifically expressed in neurons and in particular in the head nerve ring (ADE, ALA, ASI, ASK, AUA, ASG, AVH and AVJ neurons), in the ventral nerve cord, pre-anal ganglia (PVP neuron), in the tail (PHA, PHB and PHC neurons) and in vulval motor neurons VC and HSN and the vulval uv1 cells (PubMed:11086294, PubMed:11206415, PubMed:15044551, PubMed:15180830, PubMed:19343207). In males, also expressed in neurons anterior to the nerve ring and male-specific neurons in the tail (PubMed:11086294, PubMed:15180830).
messages: Lacks the typical Cys active site in position 696 that is replaced by a Ser residue, preventing the tyrosine-protein phosphatase activity.
messages: Perikaryon
messages: Proteolytically cleaved probably at a dibasic consensus sequence by egl-3.
messages: Regulates dense-core vesicle (DCV) trafficking and/or secretion (PubMed:19343207). Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord (PubMed:27116976). Involved in locomotion by regulating acetylcholine release (PubMed:15044551). Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271). Plays a role in preventing dauer formation (PubMed:15044551).
messages: Viable and fertile with a reduced brood size (PubMed:15044551, PubMed:19343207). Locomotion is slightly slower and the expulsion step of the defecation cycle is often missing (PubMed:15044551). In males, impaired mating turning behavior characterized by abnormal repetitive turning during the first turn (PubMed:17611271). 50 percent reduction in dense-core vesicles in ventral cord neurons (PubMed:19343207). Paralysis induced by acetylcholinesterase inhibitor aldicarb is reduced in 50 percent of mutants (PubMed:15044551). Resistant to aldicarb-induced reduction in brood size (PubMed:19343207). In a unc-64 (e246) mutant background increases dauer formation whereas in a unc-31 (e169) abolishes dauer formation (PubMed:15044551). In a daf-2 (e1370) or daf-28 (sa191) mutant background increases dauer formation (PubMed:15044551). In a nid-1 (cg119) mutant background, abnormal cross-over of the AVG neuron axon during the formation of the right axon tract of the ventral nerve cord (PubMed:27116976).
messages: axon
messages: dendrite

6239:CELE C27B7.6
gene id: 6239:CELE_C27B7.6
uniprot id: P48460
names: Cofactor
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.

6239:CELE K08E7.7
gene id: 6239:CELE_K08E7.7
uniprot id: Q21346
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cullin family.
messages: Neddylated; which enhances the ubiquitination activity of SCF-like complex.
messages: Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Probably interacts with skr-3.

6239:CELE F42A9.2
gene id: 6239:CELE_F42A9.2
uniprot id: Q20318
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed from mid-blastula.
messages: Nucleus
messages: Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons (PubMed:20923973). Involved in determining cell fate in the ASE neurons (PubMed:20923973). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5 (PubMed:10648230). May play an analogous role to the trithorax Group (trxG) proteins (PubMed:10648230). TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development (PubMed:10648230). May act via a modification of chromatin (PubMed:10648230).
messages: Widely expressed throughout embryonic development and into adulthood.

6239:KEF34 p10
gene id: 6239:KEF34_p10
uniprot id: G4XR16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y48G1A.6
gene id: 6239:CELE_Y48G1A.6
uniprot id: A0SQM0
names: Disruption Phenotype
names: Subunit
messages: Interacts with histone H3 that is trimethylated at 'Lys-9' (H3K9me3).
messages: No visible phenotype.

6239:CELE R06C1.2
gene id: 6239:CELE_R06C1.2
uniprot id: O62336
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

6239:CELE Y37H2A.1
gene id: 6239:CELE_Y37H2A.1
uniprot id: F3Y5R9
uniprot id: Q9U2N7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6239:CELE F02D8.4
gene id: 6239:CELE_F02D8.4
uniprot id: G5EC96
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE Y54E5B.1
gene id: 6239:CELE_Y54E5B.1
uniprot id: Q17330
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: May function in growth cone guidance.
messages: Membrane

6239:CELE F54D7.7
gene id: 6239:CELE_F54D7.7
uniprot id: A0A0M6VD87
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

6239:CELE R03G5.1
gene id: 6239:CELE_R03G5.1
uniprot id: P53013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

6239:CELE F25H8.2
gene id: 6239:CELE_F25H8.2
uniprot id: Q19788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

6239:CELE W08D2.8
gene id: 6239:CELE_W08D2.8
uniprot id: G5EBM6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F36G9.1
gene id: 6239:CELE_F36G9.1
uniprot id: O45472
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F46E10.1
gene id: 6239:CELE_F46E10.1
uniprot id: Q5TKA4
uniprot id: Q9UAV8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE C18A3.2
gene id: 6239:CELE_C18A3.2
uniprot id: Q09957
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F26F4.13
gene id: 6239:CELE_F26F4.13
uniprot id: Q8MNT1
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

6239:CELE Y69A2AR.2
gene id: 6239:CELE_Y69A2AR.2
uniprot id: Q9GSX9
uniprot id: U4PS45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synembryn family.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors. While it acts as a GEF for goa-1, it has no GEF activity toward gpa-16. In addition to its GEF activity, it is required for cortical subcellular localization of G-alpha proteins such as gpa-16. Also required for the interaction of goa-1 and gpr-1/2, suggesting that it may act by generating G-alpha proteins free from G-beta-gamma subunits, enabling gpr-1/2 to mediate asymmetric cell division.
messages: Interacts with GDP-bound G-alpha proteins goa-1 and gpa-16. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
messages: Present throughout the nervous system in juveniles and adults (at protein level).
messages: cell cortex

6239:CELE ZC334.3
gene id: 6239:CELE_ZC334.3
uniprot id: Q9U1P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F08F3.2
gene id: 6239:CELE_F08F3.2
uniprot id: G8JY39
uniprot id: Q22949
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Mitochondrion membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

6239:CELE C05E11.6
gene id: 6239:CELE_C05E11.6
uniprot id: Q17662
names: Similarity
messages: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.

6239:CELE C27H5.8
gene id: 6239:CELE_C27H5.8
uniprot id: Q95QT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE M01F1.5
gene id: 6239:CELE_M01F1.5
uniprot id: Q21455
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in the intestine and sheath glial cells.
messages: H(+)-myo-inositol cotransporter.
messages: In contrast to family members hmit-1.1 and hmit-1.2, it is not induced by hyperosmotic stress.
messages: Perikaryon

6239:CELE C49C3.4
gene id: 6239:CELE_C49C3.4
uniprot id: A0A0K3ARI2
uniprot id: Q9XUF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F28D1.10
gene id: 6239:CELE_F28D1.10
uniprot id: P55163
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cytoplasm
messages: Embryonic lethality with cells differentiating, but failing to become organized (PubMed:11877381). External hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448). RNAi-mediated knockdown results in abherrent inx-3-positive gap junction formation along the adjoining membranes of EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis (PubMed:33238150).
messages: Expressed in neurons.
messages: Interacts with aco-1, gei-13 and gex-2.
messages: Rac effector required for tissue morphogenesis, cell migrations and egg laying (PubMed:11877381). May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of gap junctions between EA and EP endodermal precursor cells in embryos (PubMed:33238150).

6239:CELE R09E10.5
gene id: 6239:CELE_R09E10.5
uniprot id: Q21874
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C17E4.6
gene id: 6239:CELE_C17E4.6
uniprot id: Q93230
names: Similarity
messages: Belongs to the VPS72/YL1 family.

6239:CELE ZK849.5
gene id: 6239:CELE_ZK849.5
uniprot id: O18304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE C17E7.8
gene id: 6239:CELE_C17E7.8
uniprot id: B1GRK4
uniprot id: O16391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F41D9.5
gene id: 6239:CELE_F41D9.5
uniprot id: Q94225
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Possible sulfate transporter.

6239:CELE F56D1.1
gene id: 6239:CELE_F56D1.1
uniprot id: Q10127
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T07C12.6
gene id: 6239:CELE_T07C12.6
uniprot id: Q22284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE K04F10.4
gene id: 6239:CELE_K04F10.4
uniprot id: P51559
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Binds 3 calcium ions per subunit.
messages: Expression starts at the two-fold embryonic stage throughout adulthood (PubMed:7774813, PubMed:19716386). Expression increases during L2-L3, L3-L4 and L4-adult molting stages (PubMed:19716386).
messages: In larvae and adults, expressed in all hypodermal cells, vulva and ventral nerve cords.
messages: Membrane
messages: RNAi-mediated knockdown causes an arrest at the L1 developmental stage (PubMed:19716386). RNAi-mediated knockdown in ASEL neuron results in a severe reduction in Ca(2+) signal in ASEL neuron and in chemotaxis in response to high salt concentrations (PubMed:24013594).
messages: Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form (PubMed:24013594). Essential for embryonic and larval development (PubMed:7774813, PubMed:10903434, PubMed:19716386). isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development (PubMed:7774813, PubMed:10903434).

6239:CELE T01H8.5
gene id: 6239:CELE_T01H8.5
uniprot id: G5EGJ6
uniprot id: G5EGP7
uniprot id: Q93971
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily.
messages: Expressed both maternally and zygotically during embryonic development. Zygotic expression starts during early embryonic cleavage.
messages: Gonads.
messages: Membrane
messages: Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel.

6239:CELE Y48E1B.14
gene id: 6239:CELE_Y48E1B.14
uniprot id: G5EF63
names: Similarity
messages: Belongs to the sorting nexin family.

6239:CELE AH6.14
gene id: 6239:CELE_AH6.14
uniprot id: Q09212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C52D10.7
gene id: 6239:CELE_C52D10.7
uniprot id: G5EFA9
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE R07B7.13
gene id: 6239:CELE_R07B7.13
uniprot id: N1NTC6
uniprot id: Q21803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y38F2AR.2
gene id: 6239:CELE_Y38F2AR.2
uniprot id: Q95XS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

6239:CELE F40A3.5
gene id: 6239:CELE_F40A3.5
uniprot id: O16262
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Expressed in the epidermis of larvae and adults and in vulval and rectal cells.
messages: Membrane
messages: Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE R05D7.3
gene id: 6239:CELE_R05D7.3
uniprot id: J7SA63
uniprot id: J7SEZ9
uniprot id: J7SF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

6239:CELE C14F11.1
gene id: 6239:CELE_C14F11.1
uniprot id: Q17994
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE F27C1.8
gene id: 6239:CELE_F27C1.8
uniprot id: P91285
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: May be a substrate of bli-4.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE Y37D8A.8
gene id: 6239:CELE_Y37D8A.8
uniprot id: Q9XWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE T27E9.3
gene id: 6239:CELE_T27E9.3
uniprot id: G5ECH7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Binds 2 Mg(2+) ions.
messages: Cytoplasm
messages: Heterodimer composed of a catalytic subunit cdk-5 and a regulatory subunit cdka-1. Interaction with cdka-1 is required for cdk-5 activation.
messages: Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1 (PubMed:17671168, PubMed:21609829). Involved in the inhibition of glr-1 trafficking in hypoxic conditions (PubMed:22252129). In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport (PubMed:20510931). Regulates the trafficking of dense-core vesicles in DA and DB motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite (PubMed:22699897). May regulate these processes in association with cdka-1/p35 (PubMed:17671168, PubMed:20510931). Activity may be regulated by cyy-1 (PubMed:20510931). Involved in synapse formation during DD motor neuron remodeling by regulating transport of disassembled synaptic material to the new synaptic sites probably by activating the motor protein unc-104/kinesin-3 (PubMed:21609829). Regulates microtubule polarity in the dendrite of DB motor neurons (PubMed:22699897). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: Several glr-1-dependent behaviors are affected including an absence of backward locomotion after nose-touching stimuli and a reduction in reverse locomotion (PubMed:17671168). In L4 mutants, incomplete elimination of ventral rab-3-positive synaptic vesicles associated with a delay in the formation of dorsal rab-3-positive synaptic vesicles in DD motor neurons. Normal formation of ventral synapses in DD motor neurons at the L1 stage (PubMed:21609829). In addition, mutants have an increase in anterograde dense-core vesicle trafficking and in the number of plus-end-out microtubules in DB motor neuron dendrites (PubMed:22699897). Reduced sensitivity to the acetylcholine esterase inhibitor aldicarb (PubMed:22699897). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).
messages: dendrite

6239:CELE R01B10.1
gene id: 6239:CELE_R01B10.1
uniprot id: G5ECM9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cystatin family.
messages: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (PubMed:12704112, PubMed:15664654). Does not inhibit asparaginyl endopeptidase (PubMed:15664654). Required for the uptake and/or processing of yolk proteins during the development of oocytes, probably by regulating the catalytic activity of cysteine proteases cpl-1 and cpz-1 (PubMed:16857685). May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation (PubMed:24001183).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:15664654, PubMed:16857685). Expressed in the ecdysed cuticle during molting (at protein level) (PubMed:16857685). In embryos and larvae, expressed in intestinal, hypodermal and pharyngeal cells (PubMed:16857685). Expression transiently increases during early embryonic stages and prior to the larval L1/L2, L2/L3, L3/L4 and L4/adult molts (PubMed:16857685).
messages: Expressed in germ cells, developing oocytes and sperm, sheath cells surrounding germ cells and oocytes and in the eggshell (at protein level) (PubMed:16857685). Expressed in the pharyngeal gland, pharyngeal muscles and some hypodermal cells in the tail (PubMed:16857685).
messages: Secreted

6239:CELE T06C12.13
gene id: 6239:CELE_T06C12.13
uniprot id: L8E924
uniprot id: O18048
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK757.2
gene id: 6239:CELE_ZK757.2
uniprot id: P34680
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

6239:CELE F32B4.4
gene id: 6239:CELE_F32B4.4
uniprot id: O62203
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in most tissues including the hypodermal, muscle, neuronal, vulval and intestinal tissues (PubMed:30965033). Isoform a: Expressed in the pharynx, nerve ring, intestine, neurons and ventral nerve cord (PubMed:30965033).
messages: Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding (PubMed:8462849, PubMed:21750263, PubMed:30965033). Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine (PubMed:30965033). Has a role in the determination of life span (PubMed:30965033).
messages: Nucleus
messages: Viable, but have an extended lifespan (PubMed:30965033). There is a decrease in early progeny production, resulting in smaller self-fertile brood size, and an increase in late progeny production, which results in an extended self-fertile reproductive lifespan (PubMed:30965033). Defective pharyngeal grinder positioning, which results in feeding defects (PubMed:8462849). Animals also have protruding male spicules (PubMed:8462849).

6239:CELE H17B01.4
gene id: 6239:CELE_H17B01.4
uniprot id: H2L0C0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y4C6B.4
gene id: 6239:CELE_Y4C6B.4
uniprot id: Q8ITV2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F07F6.5
gene id: 6239:CELE_F07F6.5
uniprot id: Q09304
names: Function
names: Subcellular Location Annotation
messages: Acts downstream of daf-16/foxo to suppress tumors induced by disruption of gld-1. Potentially a direct target of daf-15/foxo.
messages: Membrane

6239:CELE C38D4.9
gene id: 6239:CELE_C38D4.9
uniprot id: Q18511
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Catalytic subunit of a heterodimer with TRMT112/C04H5.1, which specifically methylates the 6th position of adenine in position 1717 of 18S rRNA.
messages: Heterodimer; heterodimerizes with TRMT112/C04H5.1.
messages: Worms are viable and do not display obvious developmental defects; they however exhibit significantly longer lifespan and heat resistance (PubMed:33357433). Cells show reduced N6-methylation of adenine(1717) in 18S rRNA (PubMed:33357433).

6239:CELE F59A3.8
gene id: 6239:CELE_F59A3.8
uniprot id: P91360
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE T08B2.2
gene id: 6239:CELE_T08B2.2
uniprot id: Q9GYS2
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE F27E11.3
gene id: 6239:CELE_F27E11.3
uniprot id: G5ECQ2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Displaced anterior nerve ring and neuronal cell migration defects including irregular localization of canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right (but not the left) Q neuroblast (QR) and its descendants (PubMed:16109397, PubMed:9851916). Axon growth and guidance defects whereby some HSN, male CP neurons and CAN extend ectopic axons or branches, and furthermore some HSN irregularly route towards the ventral midline of the body (PubMed:16109397). Disorganized cells of the anterior ganglion which are normally compacted together when they form the head ganglion in wild-type animals (PubMed:16109397). Double knockout with mom-5 or cwn-2 results in enhanced CAN migration defects (PubMed:16109397). Double knockout with Wnt ligands cwn-1, cwn-2, egl-20 or frizzled protein mom-5 rescues the ALM migration defects in the single cfz-2 knockout (PubMed:16109397). Triple knockout with cwn-1 and cwn-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Expressed in two pairs of head neurons and throughout the pharynx.
messages: First expressed at the 100-cell stage of embryogenesis. During embryonic elongation, expressed in anterior, posterior and midbody cells of the embryo and in cellular projections. At hatching, expression is restricted to a few cells in the head and a pair of cells in the tail.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins (PubMed:19855022, PubMed:20711352). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to involve interactions with G-proteins (Probable). Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants (PubMed:16109397). Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20 (PubMed:16109397). May act redundantly with mom-5 to direct CAN migration (PubMed:16109397). Plays a role in the organization of head ganglion cells (PubMed:16109397). Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body (PubMed:19855022, PubMed:20711352).
messages: The FZ domain is involved in binding with Wnt ligands.

6239:CELE Y76B12C.3
gene id: 6239:CELE_Y76B12C.3
uniprot id: Q9N4C6
names: Similarity
messages: Belongs to the selenoprotein M/F family.

6239:CELE T28D6.9
gene id: 6239:CELE_T28D6.9
uniprot id: Q9U357
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PEN-2 family.
messages: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2.
messages: Endoplasmic reticulum membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
messages: Expressed from 100-cell stage in most somatic tissues, including neurons, muscle, intestine and developing vulva. Little or not expressed in early embryos.
messages: Golgi apparatus membrane

6239:CELE K05F1.2
gene id: 6239:CELE_K05F1.2
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE ZK430.2
gene id: 6239:CELE_ZK430.2
uniprot id: Q23493
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

6239:CELE B0213.12
gene id: 6239:CELE_B0213.12
uniprot id: O44657
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE R13H9.2
gene id: 6239:CELE_R13H9.2
uniprot id: Q17856
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE R03D7.1
gene id: 6239:CELE_R03D7.1
uniprot id: Q09582
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
messages: L-homocysteine is bound via the zinc atom.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity).

6239:CELE C10F3.6
gene id: 6239:CELE_C10F3.6
uniprot id: G5EFE7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:15604090). The addition is prevented if the GlcNAc residue is already fucosylated (PubMed:15604090). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds (PubMed:20062796).
messages: Golgi stack membrane
messages: Inhibited by Fe(3+), Ni(2+) and Cu(2+).
messages: May also use Ca(2+). The enzyme has substantial activity without divalent cations.

6239:CELE W01A8.6
gene id: 6239:CELE_W01A8.6
uniprot id: G5EC13
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE C43C3.2
gene id: 6239:CELE_C43C3.2
uniprot id: Q09502
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Defective octopamine signaling characterized by reduced octopamine inhibition of the aversive response initiated by ASH sensory neurons when exposed to 100% 1-octanol (PubMed:22124329). RNAi-mediated knockdown results in an inability to distinguish between different food odors (PubMed:25009271).
messages: Expressed in sensory neurons including ASER.
messages: Probable receptor for neuropeptide ligand nlp-9 that plays a role in octopamine signaling and specifically, the octapamine inhibition of aversion responses in olfactory sensory neurons (PubMed:22124329, PubMed:25009271). In AWB olfactory sensory neurons, required for the detection of preferred food sources (PubMed:25009271).

6239:CELE ZK1058.3
gene id: 6239:CELE_ZK1058.3
uniprot id: Q27536
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

6239:CELE R10H10.1
gene id: 6239:CELE_R10H10.1
uniprot id: Q21915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion
messages: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.

6239:CELE T01H10.5
gene id: 6239:CELE_T01H10.5
uniprot id: Q22083
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE W06A7.4
gene id: 6239:CELE_W06A7.4
uniprot id: H2L2D7
uniprot id: Q23189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE R08D7.1
gene id: 6239:CELE_R08D7.1
uniprot id: P30640
names: Similarity
messages: Belongs to the CWC26 family.

6239:CELE K04H4.1
gene id: 6239:CELE_K04H4.1
uniprot id: P17139
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: At 20 degrees Celsius, there is reduced axon regeneration following injury in D-type motor neurons in temperature-sensitive mutant embryos.
messages: Belongs to the type IV collagen family.
messages: Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons (PubMed:25080592). May play a role in axon regeneration in embryos following injury in D-type motor neurons (PubMed:27984580).
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
messages: Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

6239:CELE R31.1
gene id: 6239:CELE_R31.1
uniprot id: G5EBH3
uniprot id: G5EC35
uniprot id: G5EFW3
uniprot id: G5EG97
names: Similarity
messages: Belongs to the spectrin family.

6239:CELE F37B4.9
gene id: 6239:CELE_F37B4.9
uniprot id: O45169
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T11F9.4
gene id: 6239:CELE_T11F9.4
uniprot id: Q22397
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility (PubMed:30560135).
messages: Apical cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Expressed at the apical cell membrane of intestinal cells.
messages: Interacts (via PDZ-binding motif) with nfrl-1 (via PDZ 2 domain); the interaction with nrfl-1 is required to sequester aat-6 to the apical cell membrane of intestinal cells.

6239:CELE T11G6.8
gene id: 6239:CELE_T11G6.8
uniprot id: Q22412
names: Similarity
messages: Belongs to the SLT11 family.

6239:CELE ZK488.4
gene id: 6239:CELE_ZK488.4
uniprot id: O17020
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08E7.3
gene id: 6239:CELE_K08E7.3
uniprot id: Q21341
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Required for the proper orientation of spindles after the establishment of polarity (PubMed:9477332, PubMed:14534135). May play a role in interactions between the astral microtubules and the cortical cytoskeleton (PubMed:9477332). Required for asymmetric forces on nuclei and spindles (PubMed:9477332). Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation (PubMed:12223405). Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions (PubMed:14534135). Acts antagonistically to the gpr-1/2 signaling pathway (PubMed:14534135). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841).
messages: cell cortex

6239:CELE F52C12.5
gene id: 6239:CELE_F52C12.5
uniprot id: G5EGN3
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryos at the ~1.5-fold and ~2.5-fold stages in several cells in the head region, perhaps neurons and/or support cells, and expressed at lower levels in seam cells (at protein level) (PubMed:11532911). Expressed in head region of L1-stage larvae, perhaps in neurons and/or support cells; also expressed in seam cells at this stage (PubMed:11532911). Expressed in the vulval precursor cell (VPC) lineages and in VC neurons, starting at about the mid-L2 larval stage (PubMed:12399309). Expression in the head increases with age between days 2 and 12 (PubMed:18662544).
messages: Expressed in the head.
messages: Not only are egl-18/elt-5 and elt-6 moderately similar (46% identical) paralogous genes, but they may be transcribed both monocistronically and dicistronically in a tissue-dependent manner, so complicating interpretation of knockdown and expression experiments.
messages: Nucleus
messages: RNAi-mediated knockdown at day 5 of adulthood (earlier RNAi treatment causes worms to become sick) causes extended longevity and also increases expression of elt-3 in the trunk hypodermis; longevity effect is suppressed in an elt-3 mutant background (PubMed:18662544). RNAi-mediated knockdown at the L1 stage has little effect on the average number of seam cells per side, but the number is reduced in an egl-18 mutant background (PubMed:23633508). RNAi-mediated knockdown at the embryonic or L3 stages reduces expression of lin-39; expression is reduced further in an egl-18 mutant background.
messages: Transcription factor (PubMed:11532911, PubMed:24885717). Binds to the sequence 5'-TGATAA-3' in regulatory elements of target genes, such as lin-39 (PubMed:24885717). Involved in embryonic development and in vulval development in larvae, acting redundantly, at least in part, with egl-18 (PubMed:11532911, PubMed:14975731, PubMed:12399309, PubMed:24885717). Perhaps acting together with egl-18, may form a positive feedback loop to initiate and maintain lin-39 gene expression to ensure proper vulval precursor cell (VPC) fate specification (PubMed:24885717). Together with egl-18, acts as a downstream target of the Wnt/beta-catenin asymmetry pathway, required to adopt or maintain the seam cell fate (PubMed:23633508). Required in seam cells, acting redundantly with egl-18, to promote production of alae, expression of several seam-specific genes and maintenance of seam cells in an unfused state (PubMed:11532911, PubMed:23633508). Plays a role in longevity (PubMed:18662544). May form a transcriptional circuit with GATA factors egl-18 and elt-3 (PubMed:18662544).

6239:CELE F59A2.5
gene id: 6239:CELE_F59A2.5
uniprot id: Q21019
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

6239:CELE Y51F10.3
gene id: 6239:CELE_Y51F10.3
uniprot id: Q8WTJ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F15A2.3
gene id: 6239:CELE_F15A2.3
uniprot id: Q19473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F43G9.3
gene id: 6239:CELE_F43G9.3
uniprot id: Q93717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE B0207.3
gene id: 6239:CELE_B0207.3
uniprot id: Q9BIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with the dopamine receptor dop-2 (via C-terminus); the interaction is direct (PubMed:22280843).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In association with the G-protein coupled dopamine receptor dop-2, modulates two types of learning: touch habituation and chemosensory associative conditioning (PubMed:23607404).

6239:CELE Y92H12A.1
gene id: 6239:CELE_Y92H12A.1
uniprot id: G5EE56
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Expressed in some neurons (ASE, ADF, AVA, AUA, RMDV and BAG) in the head region, anchor cell, vulva, cells around anus, body wall muscle, pharyngeal muscles in procorpus and metacorpus (PubMed:12527374). Expressed in gonadal distal tip cells (PubMed:12527374, PubMed:16251208).
messages: Interacts (via SH2 domain and SH3 domain) with unc-5 (via cytoplasmic domain); the interaction requires kinase activity (PubMed:16024786). Interacts (when activated and phosphorylated at 'Tyr-416') with ina-1 (via cytoplasmic domain) and with ced-2 (via SH2 domain) (PubMed:20226672).
messages: May be activated by autophosphorylation (PubMed:19210548, PubMed:20226672). May be inhibited by csk-1-mediated phosphorylation (PubMed:12527374).
messages: May be phosphorylated on Tyr-528 by csk-1.
messages: Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, PubMed:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of the axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208, PubMed:22293500). May act downstream of migratory protein mig-13 to control AVM neuron migration (PubMed:22293500). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672). Phosphorylates ced-1 at 'Tyr-1019' which promotes ced-1 proteasomal degradation, maintaining appropriate ced-1 levels for apoptotic cell clearance (PubMed:35929733).
messages: RNAi-mediated knockdown causes a growth arrest between gastrulation and the 2-fold stage and an increase in number of apoptotic cell corpses at the comma and 1.5-fold stages (PubMed:12527374, PubMed:16024786, PubMed:20226672). The few hermaphrodite animals reaching adulthood have gonadal defects characterized by the formation of a straight gonad resulting from defects in distal tip cells migration during the first and second turns (PubMed:16251208, PubMed:16024786).
messages: phagocytic cup

6239:CELE B0218.3
gene id: 6239:CELE_B0218.3
uniprot id: Q17446
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by phosphorylation on threonine and tyrosine. Inhibited by pyridinyl-imidazole related compounds.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Divalent cations such as magnesium or manganese.
messages: Dually phosphorylated on Thr-191 and Tyr-193, probably by sek-1, which activates the enzyme (PubMed:16166371, PubMed:21212236). Increased phosphorylation in response to the heavy metal arsenite (PubMed:25204677). Increased phosphorylation in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216 (PubMed:29748542).
messages: Expressed in intestinal cells.
messages: Interacts with transcription factor atf-7; perhaps in a manner dependent on dual specificity protein kinase sek-1.
messages: Knockout causes reduction in adult lifespan (PubMed:29748542). Upon infection by P.aeruginosa or E.faecalis, RNAi-mediated knockdown results in a decrease in survival rate and in a reduced up-regulation of gst-4 and gcs-1 expression (PubMed:12142542, PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034). Upon exposure to C.cinerea galectin Cgl2, adults show reduced survival and larvae do not develop (PubMed:20062796). Larval development is partially restored in a bre-1, fut-8, gly-13, galt-1 or ger-1 mutant background (PubMed:20062796).
messages: Nucleus
messages: Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898, PubMed:22308034, PubMed:20369020). As part of a MAP kinase signaling pathway, plays a role in modulation of lifespan and immunity (PubMed:29748542, PubMed:12142542, PubMed:20369020, PubMed:22216003). Phosphorylates skn-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress (PubMed:16166371). Probably by activating skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection (PubMed:22216003). Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment (PubMed:16166371, PubMed:25204677). Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase which regulates pathogen resistance and responses to oxidative stress (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898). Required for expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury (PubMed:18394898). Involved in resistance to the nematotoxic C.cinerea galectin (Cgl2) (PubMed:20062796). May play a redundant role with other MAP kinases in susceptibility to anoxia, downstream of tir-1/nsy-1 (PubMed:21212236). Phosphorylates transcription factor rnt-1 during oxidative stress which results in rnt-1 stabilization in the intestine (PubMed:22308034). Phosphorylates transcription factor atf-7 during pathogen infection resulting in modulation of target genes (PubMed:20369020). Probably downstream of nsy-1 and sek-1, involved in germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:19497412).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

6239:CELE D1054.14
gene id: 6239:CELE_D1054.14
uniprot id: Q18942
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

6239:CELE E02D9.3
gene id: 6239:CELE_E02D9.3
uniprot id: Q9TYV7
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE W09H1.5
gene id: 6239:CELE_W09H1.5
uniprot id: O45903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.
messages: Homodimer.
messages: Mitochondrion

6239:CELE C17D12.2
gene id: 6239:CELE_C17D12.2
uniprot id: A0A0K3AWH2
uniprot id: G5EE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

6239:CELE Y67H2A.1
gene id: 6239:CELE_Y67H2A.1
uniprot id: Q95PY8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0280.11
gene id: 6239:CELE_B0280.11
uniprot id: P42083
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

6239:CELE F26D2.3
gene id: 6239:CELE_F26D2.3
uniprot id: Q9U3H9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C38D4.3
gene id: 6239:CELE_C38D4.3
uniprot id: Q18508
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Chromosome
messages: Expressed at all stages of development.
messages: Nuclear envelope protein which has essential roles in assembly of nuclear pore complexes and in chromatin maintenance during the cell cycle (PubMed:16950114, PubMed:16950115, PubMed:26166571, PubMed:27341616). Appears to be a stable structural component of the nuclear envelope during interphase (PubMed:16950114, PubMed:16950115). In dividing cells, localizes to kinetochores during early stages of mitosis and then to chromatin during late mitosis (PubMed:16950114, PubMed:27341616). Important for several mitotic processes including chromosome condensation, kinetochore assembly, chromosome segregation and cell-cycle timing (PubMed:16950114, PubMed:16950115, PubMed:26166571, PubMed:27341616). In postmitotic cells, plays a role in the early steps of nuclear pore complex assembly by recruiting the nucleoporins npp-10 and npp-5 to chromatin (PubMed:16950114, PubMed:16950115). Also involved in meiotic chromosome segregation (PubMed:27341616). May function downstream of the Ran GTPase signaling pathway (PubMed:16950115).
messages: Nucleus
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:16950114). Impairs assembly of the nuclear pore complex, the integrity of the nuclear envelope and distribution of the integral nuclear envelope proteins lmn-1, lem-2 and emr-1 and the nuclear pore complex proteins npp-9, npp-10 and npp-1 (PubMed:16950114, PubMed:16950115). Reduces the recruitment of npp-10 and npp-5 to chromatin (PubMed:16950114). Leads to hypercondensation and mispositioning of chromatin, defects in migration and positioning of the pronuclei, dissociation of centrosomes from chromatin, precocious centrosome separation, as well as defects in kinetochore assembly, spindle assembly, chromosome segregation and chromatin distribution in meiosis and mitosis (PubMed:16950114, PubMed:16950115). Impairs mitotic progression and leads to chromatin bridges (PubMed:16950114, PubMed:16950115). Reduces knl-3 localization to the kinetochores (PubMed:16950115). Suppresses the chromosome-decondensation defect in evl-18/cdc-45 mutant embryos (PubMed:26166571).
messages: Ubiquitously expressed (at protein level).
messages: kinetochore
messages: nuclear pore complex
messages: nucleoplasm

6239:CELE T05B4.9
gene id: 6239:CELE_T05B4.9
uniprot id: O16418
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F23F12.6
gene id: 6239:CELE_F23F12.6
uniprot id: P46502
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

6239:CELE F15A2.2
gene id: 6239:CELE_F15A2.2
uniprot id: G5EDP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

6239:CELE W03A5.6
gene id: 6239:CELE_W03A5.6
uniprot id: Q23138
names: Similarity
messages: Belongs to the SAPAP family.

6239:CELE T15B7.2
gene id: 6239:CELE_T15B7.2
uniprot id: O17040
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Membrane

6239:CELE T05B4.10
gene id: 6239:CELE_T05B4.10
uniprot id: O16419
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0414.6
gene id: 6239:CELE_B0414.6
uniprot id: O01836
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
messages: Cytoplasm
messages: During germline proliferation.
messages: Interacts with csn-5. Interacts (via C-terminus) with kgb-1. Interacts with zyx-1.
messages: Probable ATP-binding RNA helicase.

6239:CELE ZK593.1
gene id: 6239:CELE_ZK593.1
uniprot id: D3YT36
uniprot id: D3YT37
uniprot id: Q23539
names: Similarity
messages: Belongs to the pyruvate kinase family.

6239:CELE F32D8.14
gene id: 6239:CELE_F32D8.14
uniprot id: H9G2X8
uniprot id: Q7YTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE W05H5.5
gene id: 6239:CELE_W05H5.5
uniprot id: Q5FC42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F54D5.11
gene id: 6239:CELE_F54D5.11
uniprot id: G5EG47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

6239:CELE Y37D8A.13
gene id: 6239:CELE_Y37D8A.13
uniprot id: G5EFD5
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Contains a metallopeptidase domain, but the active site is not conserved, so the protein is not expected to have protease activity.
messages: Defective sex myoblast migration (PubMed:9073451). Motor neuron axon guidance defects with aberrant axon branching in type D motor neurons (PubMed:12783787).
messages: Expressed throughout development (PubMed:8970152, PubMed:12783787, PubMed:22293500). First expressed in several posterior cells of comma stage embryos (PubMed:12783787). Expressed in the excretory cell and in some head neurons in threefold stage embryos (PubMed:12783787). At the L1 stage of larval development expressed in the syncytial hypodermis (PubMed:8970152). From the L1 stage of larval development to adulthood, expressed in head neurons, the excretory cell, excretory gland cells and in the sphincter muscle (PubMed:12783787, PubMed:22293500). From the L4 stage of larval development to adulthood, expressed in hypodermal cells surrounding the vulva (PubMed:12783787).
messages: Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development (PubMed:9073451, PubMed:12783787, PubMed:22293500). Involved in axon branching and guidance of neurons including GABAergic type D motor neurons (PubMed:12783787). Promotes sex myoblast migration and positioning independently of gonad attraction cues (PubMed:9073451, PubMed:12783787). May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis (PubMed:22293500). Required for coordinated movements (PubMed:12783787).

6239:CELE M01G12.7
gene id: 6239:CELE_M01G12.7
uniprot id: O62313
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE C03H5.1
gene id: 6239:CELE_C03H5.1
uniprot id: O16660
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F53F8.1
gene id: 6239:CELE_F53F8.1
uniprot id: O62259
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in all developmental stages, increasing gradually from embryo to larval L3 stage, decreasing in L4 and stabilizing in adult stage.
messages: Expressed predominantly in intestine.
messages: Expression is repressed in response to high levels of dietary calcium.
messages: Lipid contents in the intestine increase by 44%, but increase is less in response to high levels of dietary calcium.
messages: Nucleus
messages: Probable transcription factor which regulates lipid metabolism.

6239:CELE B0365.6
gene id: 6239:CELE_B0365.6
uniprot id: P90732
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F11F1.6
gene id: 6239:CELE_F11F1.6
uniprot id: O45348
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in body wall muscle.
messages: Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane.
messages: basement membrane

6239:CELE C33H5.19
gene id: 6239:CELE_C33H5.19
uniprot id: Q95QS6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T09B9.3
gene id: 6239:CELE_T09B9.3
uniprot id: Q10049
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C42D4.8
gene id: 6239:CELE_C42D4.8
uniprot id: Q18566
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

6239:CELE F25C8.5
gene id: 6239:CELE_F25C8.5
uniprot id: Q564U4
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in embryos and adults.
messages: Expressed in head sensory neurons.
messages: Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior (PubMed:27635036). Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth (PubMed:23000142).

6239:CELE M03F8.7
gene id: 6239:CELE_M03F8.7
uniprot id: C3JXE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T20G5.6
gene id: 6239:CELE_T20G5.6
uniprot id: P34579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic vesicle membrane
messages: Involved in the uptake of GABA into the synaptic vesicles.

6239:CELE ZK617.1
gene id: 6239:CELE_ZK617.1
uniprot id: A0A061ACT3
uniprot id: A0A061AE24
uniprot id: H2FLH2
uniprot id: H2FLH3
uniprot id: Q23551
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Body muscles are unable to develop or sustain normal contractions but small regions within the myofilament lattice of individual muscle cells contract transiently in the absence of contraction of the adjacent lattice (PubMed:16765996, PubMed:7190524). This results in a nearly constant body twitching phenotype (PubMed:16765996, PubMed:7190524, PubMed:25851606). Resistant to nicotine-induced paralysis (PubMed:25851606).
messages: Determination of the mutation frequency of the unc-22 gene has been used to study the biological effects of short duration spaceflight.
messages: Expressed in body wall, anal, vulval, and pharyngeal muscles (at protein level).
messages: Forces generated by the contraction/relaxation cycles of muscle activity separate the regulatory domain from the catalytic core, activating the enzyme. At rest, the kinase domain is in a closed conformation. The active site is occupied by the autoinhibitory region (CDR), which makes extensive contact with the catalytic site, blocking substrate binding. At low forces the regulatory tail will unravel reversibly and expose the active site to its substrates, potentially stabilized by binding of Ca/CALM. At high forces the kinase begins to unfold and the integrity of the active site is disrupted.
messages: May interact (via protein kinase and CRD domains) with mak-1 (via protein kinase domain).
messages: Phosphorylated by mak-1 on the protein kinase domain and/or CDR domain in vitro.
messages: Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces (PubMed:18390597, PubMed:7190524). Plays a role in the organization of sarcomeres in body wall muscles (PubMed:25851606).
messages: sarcomere

6239:CELE T10B9.7
gene id: 6239:CELE_T10B9.7
uniprot id: Q27518
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE D2096.8
gene id: 6239:CELE_D2096.8
uniprot id: Q19007
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

6239:CELE Y39E4B.12
gene id: 6239:CELE_Y39E4B.12
uniprot id: Q95ZJ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: Golgi apparatus membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE C24G7.2
gene id: 6239:CELE_C24G7.2
uniprot id: P91102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE T12C9.1
gene id: 6239:CELE_T12C9.1
uniprot id: Q95QB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK6.2
gene id: 6239:CELE_ZK6.2
uniprot id: O61872
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T22C8.8
gene id: 6239:CELE_T22C8.8
uniprot id: G5ED30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

6239:CELE Y77E11A.6
gene id: 6239:CELE_Y77E11A.6
uniprot id: Q9N4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

6239:CELE C29F9.7
gene id: 6239:CELE_C29F9.7
uniprot id: Q9TZC4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basal cell membrane
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Embryonic lethality due to 1.5 fold stage-onset paralysis. Mutant embryos have defects in maintaining polarization of several components involved in the assembly of dense bodies and M lines, such as integrin pat-3, unc-89 and unc-112 to muscle attachment sites (PubMed:12015115). RNAi-mediated knockdown causes sterility resulting from oocyte accumulation in the proximal gonad and distal tip cell (DTC) migration defects (33 percent of animals). Actin cytoskeleton in the proximal gonad appears disorganized (PubMed:16476426). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in hatched embryos but not in adults causes adult-onset paralysis characterized by the collapse of myosin filaments in body wall muscles and a decrease in pharyngeal pumping (PubMed:24314125). In L1 larval stage, results in the formation of large myosin aggregates in body wall muscle cells (PubMed:22761445). In L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). In adults, causes an increase in lifespan, resistance to heat stress and increased expression of stress response factors hsf-1, sod-3, hsp-16.2 and gst-4 (PubMed:24314125).
messages: Expressed in body wall muscle.
messages: Expression starts in body wall muscles at the 1.5-fold embryonic stage.
messages: Interacts (via protein kinase domain) with unc-112 (via N-terminus) (PubMed:12015115, PubMed:24692564). Interacts (via ANK repeats) with unc-97 (via first LIM domain) (PubMed:12015115, PubMed:17662976). Interacts (via protein kinase domain) with pat-6 (via C-terminus CH domain) (PubMed:12781130). May form a complex with unc-112, unc-97 and pat-6 (PubMed:12781130, PubMed:17662976, PubMed:24692564). Does not interact with integrin pat-3 (PubMed:12015115). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: M line
messages: Probable pseudokinase that acts as an adapter protein (PubMed:12015115, PubMed:23283987). Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc-112 to integrin-mediated attachment sites (PubMed:12015115, PubMed:23283987). Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton (PubMed:16476426). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308). May be involved in thermotolerance and lifespan (PubMed:24314125).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F36F2.4
gene id: 6239:CELE_F36F2.4
uniprot id: O62236
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

6239:CELE F54D8.3
gene id: 6239:CELE_F54D8.3
uniprot id: Q20780
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE R10E11.8
gene id: 6239:CELE_R10E11.8
uniprot id: Q21898
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adult H-shaped excretory cell and rectum.
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: High levels during embryogenesis, moderate levels during L1 and adult stages and very low levels during L2-L4 stages.
messages: Membrane
messages: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (PubMed:29168500). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (PubMed:29168500). The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates (PubMed:29168500). Lysosomal acidification also leads to changes in mitochondrial morphology and function (PubMed:29168500). Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity (PubMed:29168500). In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (PubMed:29168500). Plays a role in the processing and secretion of the aspartic protease hrg-7 from the intestine (PubMed:28581477). During embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168). Involved in receptor-mediated endocytosis (PubMed:16785323).
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:16785323). RNAi-mediated knockdown results in increased protein aggregation in the oocytes of sperm-deficient young adult females which is not eliminated by mating (PubMed:29168500). RNAi-mediated knockdown causes hyperfusion of embryonic epidermal cells (PubMed:15866168). RNAi-mediated knockdown results in the accumulation of the aspartic protease hrg-7 in its immature uncleaved form and in the intestine (PubMed:28581477). Causes defects in alae formation in the few surviving larvae and impairs yolk uptake by the oocytes from the pseudoceolomic cavities (PubMed:16785323). Causes an increase in the section of the excretory canal, which often has multiple lumens and abnormal whorls (PubMed:16785323).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE C09G5.5
gene id: 6239:CELE_C09G5.5
uniprot id: Q09456
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE F42A9.5
gene id: 6239:CELE_F42A9.5
uniprot id: Q27499
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T24B8.2
gene id: 6239:CELE_T24B8.2
uniprot id: Q22718
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE R12B2.4
gene id: 6239:CELE_R12B2.4
uniprot id: Q21952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity (PubMed:11402066, PubMed:14522947, PubMed:15371539). The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of at least ndc-80 and him-10. The NDC80 complex interacts with knl-1.
messages: Nucleus
messages: kinetochore

6239:CELE M110.2
gene id: 6239:CELE_M110.2
uniprot id: Q21529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE T14G11.3
gene id: 6239:CELE_T14G11.3
uniprot id: Q22505
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Cytoplasm
messages: Egg-laying defects, defective oogenesis in 30% of mutants, reduced brood size and increased resistance to oxidative stress inducer paraquat (PubMed:20578245). Abnormal mitochondrial morphology with mitochondria appearing larger and as localized swellings and tubular extensions (PubMed:20578245, PubMed:21248201). Mitochondria also have elongated and curved cristae that are stacked with a reduced number of junctions (PubMed:20578245, PubMed:21248201). Double knockout with immt-2 results in a more reduced brood size and enhanced resistance to paraquat-induced oxidative stress as compared to the single mutant, and in addition, mutants are slower swimmers, have increased hydrogen peroxide-induced reactive oxygen species (ROS), and reduced mitochondrial mass accompanied by reduced superoxide anion oxidation (PubMed:20578245). Double knockout with chch-3 RNAi results in reduced or no brood, poor growth and withered gonads (PubMed:21248201).
messages: Expressed in embryos.
messages: Expressed in the gonads and muscle cells.
messages: Mitochondrion inner membrane
messages: Sustains mitochondrial morphology probably through maintaining cristae morphology (PubMed:20578245, PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE C14C6.4
gene id: 6239:CELE_C14C6.4
uniprot id: O44668
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y56A3A.3
gene id: 6239:CELE_Y56A3A.3
uniprot id: Q9U228
names: Similarity
messages: Belongs to the MIF family.

6239:CELE Y47D3A.29
gene id: 6239:CELE_Y47D3A.29
uniprot id: Q9NAH1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE ZK488.2
gene id: 6239:CELE_ZK488.2
uniprot id: O17025
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y75B12B.5
gene id: 6239:CELE_Y75B12B.5
uniprot id: P52011
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:8694762, PubMed:10574961). Plays a role in protein folding, transport and assembly (PubMed:8694762, PubMed:10574961).
messages: During early larval development, peaking at the second larval stage, and dropping off in later development.
messages: Exclusively expressed in the single anterior excretory cell.

6239:CELE K03A11.1
gene id: 6239:CELE_K03A11.1
uniprot id: G5EDX0
names: Similarity
messages: Belongs to the E2F/DP family.

6239:CELE Y55F3AM.4
gene id: 6239:CELE_Y55F3AM.4
uniprot id: Q9N369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

6239:CELE T10G3.6
gene id: 6239:CELE_T10G3.6
uniprot id: E1B6V1
uniprot id: P92022
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

6239:CELE Y54G2A.31
gene id: 6239:CELE_Y54G2A.31
uniprot id: Q95XX0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own; may require ubiquitin-conjugating enzyme, ubc-13.
messages: Interacts with the E3 ubiquitin ligase nhl-1 and the E2 ubiquitin ligase ubc-1 (PubMed:15530417). Heterodimer with uev-1 (PubMed:15530417, PubMed:21179194).
messages: Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772). May have a role in AMPA-type glutamate receptor trafficking in neurons (PubMed:21179194).
messages: Temperature sensitive with partial embryonic lethality at 25 degrees Celsius (PubMed:24595290). Inhibited degradation of maternal membrane proteins, cav-1, chs-1 and rme-2, and ubiquitination of cav-1 with accumulation of these proteins on the maternal plasma membrane and endosome-like vesicles in later-stage embryos (PubMed:24595290). RNAi-mediated knockdown prevents localization of ubiquitin and proteasomes to polyglutamine protein aggregates (PubMed:17663792). Reduced growth of polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772). Inhibited degradation of maternal membrane protein, cav-1 in embryos (PubMed:24595290).

6239:CELE F36H1.4
gene id: 6239:CELE_F36H1.4
uniprot id: A0A061AD43
uniprot id: A0A061AEC4
uniprot id: Q03345
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Essential for vulval induction; acts independently of rom-1.
messages: Essential for vulval induction; its activity on vulval precursor cells is partially dependent on rom-1.
messages: Expressed at all larval stages.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes (PubMed:1641037, PubMed:15455032, PubMed:16678779, PubMed:17891142). Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation (PubMed:15194811, PubMed:9491893). Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by activating receptor lin-23-mediated signaling cascade (PubMed:17891142).
messages: RNAi-mediated knockdown in combination with double mutants for the class A and B synMuv genes lin-36;lin-15A, lin-8;lin-15B, lin-15AB, lin-35;lin-8, lin-8;lin-36, lin-8;lin-9, lin-8;lin-37 or dpl-1;lin-15A results in suppression of the synthetic multivulva phenotype.

6239:CELE F46C3.1
gene id: 6239:CELE_F46C3.1
uniprot id: Q19192
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After L2 growth stage movement is subdued and development is stunted. Increased sensitivity to tunicamycin which induces an unfolded protein response symptomatic of endoplasmic reticulum stress.
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
messages: By ER stress.
messages: Endoplasmic reticulum membrane
messages: Expressed in intestinal cells.
messages: Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells (By similarity).
messages: N-glycosylated.
messages: Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction (By similarity).
messages: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (PubMed:10677345). May phosphorylate eIF2alpha during hypoxia (PubMed:20733002). Proposed to have a role in alleviating endoplasmic reticulum stress (PubMed:10677345, PubMed:11779465, PubMed:16184190).
messages: The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP.

6239:CELE C44C10.8
gene id: 6239:CELE_C44C10.8
uniprot id: Q18612
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Adults are viable and fertile, but with a moderate frequency of somatic gonad defects, which increases on an ehn-3 mutant background (PubMed:12756172). Low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hlh-1 or unc-120 mutant background (PubMed:12756172, PubMed:15892873, PubMed:17142668). Many embryos that survive to hatch become uncoordinated, dumpy larvae with variable body shape defects, typically in the posterior (PubMed:15892873, PubMed:12756172). One quarter of the embryos from homozygous hnd-1;hlh-1 heterozygous parents exhibit reduced expression of myosin myo-3 (PubMed:17142668). On a unc-120 mutant background, progeny show reduced expression of myo-3 at mid-embryogenesis (PubMed:17142668). RNAi-mediated knockdown results in abnormal number and positioning of the somatic gonadal precursor cells (SGPs) and influences the maintenance of primordial germ cells (PGCs) in L1 larvae (PubMed:15892873).
messages: Expressed in the MS, C and D embryonic lineages, which develop into somatic gonadal precursor cells (SGPs), other mesodermal cells and bodywall muscle (PubMed:12756172). Expression is abolished in most body muscle cells by the comma stage of embryogenesis, but continues in the SGPs (Z1 and Z4), and then is abolished shortly after assembly of the gonadal primordium (PubMed:12756172).
messages: Nucleus
messages: Probable transcription factor which regulates early embryonic myogenesis, in cooperation with transcription factors unc-120 and hlh-1 (PubMed:15892873, PubMed:17142668). Involved in controlling the number and position of somatic gonadal precursor cells (SGPs) in the gonadal primordium, and embryonic body shape (PubMed:12756172).

6239:CELE Y108G3AL.2
gene id: 6239:CELE_Y108G3AL.2
uniprot id: Q95Y35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

6239:CELE B0348.6
gene id: 6239:CELE_B0348.6
uniprot id: O61955
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasmic granule
messages: Expressed from early embryogenesis (at protein level).
messages: Highly expressed in the germline (at protein level).
messages: Inactivation of ife-3 results in 100% embryonic lethality.
messages: RNAi-mediated knockdown results in maternal effect lethal (Mel phenotype) and masculinization of the germline (Mog phenotype) phenotypes (PubMed:31147388). RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388).
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Ife-3 is essential for viability. Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the pid-1 variant of the PETISCO complex binds to capped 21U-RNA precursor molecules, possibly playing a role in the processing of the 5' end of the molecules to promote binding of other complex components such as pid-3 (PubMed:31147388). However, it is not essential for the biogenesis of 21U-RNAs by itself (PubMed:31147388). Within the tost-1 variant of the PETISCO complex binds to splice leader SL1 RNA fragments to possibly play a role in their processing (PubMed:31147388).
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners. Interacts with mxt (PubMed:26294658). Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts with tofu-6 (via C-terminus) (PubMed:31216475, PubMed:31147388). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of 21U-RNAs (PubMed:31147388).
messages: perinuclear region

6239:CELE C13B4.2
gene id: 6239:CELE_C13B4.2
uniprot id: Q17361
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity).
messages: Was originally (Ref.1) thought to be a queuine tRNA-ribosyltransferase.

6239:CELE F26E4.11
gene id: 6239:CELE_F26E4.11
uniprot id: P90859
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Proposed to have a role in neuroprotection.

6239:CELE ZK858.4
gene id: 6239:CELE_ZK858.4
uniprot id: Q94420
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in body wall muscles.
messages: I band
messages: Interacts (via BTB domain) with cul-3 (PubMed:13679922, PubMed:14528312, PubMed:22621901). Seems to be a component of a E3 ubiquitin-protein ligase complex containing cul-3 (PubMed:13679922, PubMed:14528312). Interacts (probably via MATH domain) with mei-1, which targets mei-1 for ubiquitin-mediated proteolysis (PubMed:14528312, PubMed:22621901, PubMed:23918937). Interacts (probably via MATH domain) with ppfr-1, the regulatory subunit of the PP4 complex; targets ppfr-1 for ubiquitin-mediated proteolysis (PubMed:23918937). May interact (via MATH domain) with unc-89 (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) (PubMed:22621901).
messages: M line
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922, PubMed:23918937). Controls degradation of microtubule severing protein mei-1 after meiosis (PubMed:14528312). Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis (PubMed:23918937). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89 (PubMed:22621901). May also activate the TORC1 pathway (PubMed:29769719).
messages: RNAi-mediated knockdown at L1 larval stage results in the disorganization of myosin thick filaments in adult body wall muscles characterized by the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A-bands (PubMed:22621901). RNAi-mediated knockdown of mel-26 also results in increased lifespan (PubMed:29769719).

6239:CELE C30H6.6
gene id: 6239:CELE_C30H6.6
uniprot id: O45278
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y55F3AL.1
gene id: 6239:CELE_Y55F3AL.1
uniprot id: Q3V5K0
uniprot id: U4PBW0
uniprot id: U4PF39
uniprot id: U4PRY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y45F10D.3
gene id: 6239:CELE_Y45F10D.3
uniprot id: O45947
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE F44B9.1
gene id: 6239:CELE_F44B9.1
uniprot id: P34422
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE R10E11.7
gene id: 6239:CELE_R10E11.7
uniprot id: P34551
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srxa family.
messages: Membrane

6239:CELE K12D9.10
gene id: 6239:CELE_K12D9.10
uniprot id: P91385
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C36B1.14
gene id: 6239:CELE_C36B1.14
uniprot id: Q3S1J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

6239:CELE K09A9.1
gene id: 6239:CELE_K09A9.1
uniprot id: G5EED4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability (PubMed:27927209). Involved in negatively modulating pmk-1 p38/MAPK signaling (PubMed:27927209). Involved in innate immunity, acting either in a manner dependent upon, or independent of, the pmk-1 or pmk-3 p38/MAPK pathways (PubMed:18394898, PubMed:27927200, PubMed:34407394). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa, acting by negatively modulating expression of cebp-1, and regulating the pmk-1 p38/MAPK pathway, leading to activation of transcription factor skn-1 (PubMed:27927200, PubMed:34407394). Required to prevent P.aeruginosa toxin ToxA-mediated lethality, probably acting via modulating the effects of translational inhibition caused by the toxin (PubMed:27927200). By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection (PubMed:18394898, PubMed:27927200).
messages: Arrested development at the second to third larval stages (L2-L3) and lethality between 5-10 days after hatching (PubMed:27927209). Small and dumpy body morphology at the second to third larval stages (L2-L3), abnormal pharyngeal morphology, sterility (PubMed:27927209). Growth and fertility defects are suppressed in a cebp-1 mutant background (PubMed:27927209). Lethality is suppressed in several mutant backgrounds, including tir-1, or kinases nsy-1, sek-1 or mak-2 (PubMed:27927209). Levels of phosphorylated, active p38/MAPK pmk-1 are significantly increased (PubMed:27927209). Increased levels of cebp-1 mRNA in multiple tissues (PubMed:27927209). RNAi-mediated knockdown results in a loss of nlp-29 expression upon fungal infection (PubMed:18394898). No other obvious phenotype (PubMed:18394898). Knockdown results in a drastic reduction in transcription of gst-4 and gcs-1 mRNAs during infection by P.aeruginosa or P.faecalis, or treatment with the oxidant, arsenite (PubMed:34407394). RNAi-mediated knockdown targeted to intestinal cells causes hypersusceptibility to Gram-negative bacterium P.aeruginosa or to Gram-positive bacterium E.faecalis and also to the P.aeruginosa toxin ToxA (PubMed:27927200, PubMed:34407394). Simultaneous knockdown with vhp-1, targeted to intestinal cells, results in partial rescue of the nipi-3 pathogen sensitivity phenotype (PubMed:34407394).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Expressed in epidermis, pharynx, intestine, a subset of head neurons and motoneurons.
messages: Expressed in the 3-fold stage embryo.
messages: May interact with transcription factor cebp-1 (via N-terminus).
messages: Nucleus
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE T03E6.7
gene id: 6239:CELE_T03E6.7
uniprot id: O45734
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Cysteine protease which plays an essential role in the degradation of proteins in lysosomes (PubMed:15456850, PubMed:24829385). During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome-like structure where a slow and controlled degradation of yolk proteins occurs (PubMed:15456850, PubMed:24829385). In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes (PubMed:24829385). In embryos, required for the degradation of endocytic and autophagic cargos (PubMed:24829385). In embryos, may play a role in the degradation of lipid-containing droplets (PubMed:26773047). Required for larval development (PubMed:11707440, PubMed:15456850).
messages: Cytoplasmic granule
messages: Endosome
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:11707440, PubMed:15456850, PubMed:16857685, PubMed:24829385). Expression transiently increases during early embryonic stages and prior to the larval L1/L2, L2/L3, L3/L4 and L4/adult molts (PubMed:11707440, PubMed:16857685). Highest expression in adults (PubMed:11707440). In embryos, expressed in gut cells (PubMed:11707440). In larvae, expressed in the hypodermis, intestine and pharyngeal lining (PubMed:11707440). In molting larvae, expressed in the old and new cuticle (PubMed:11707440).
messages: Expressed in intestine, pharynx posterior bulb, hypodermis and cuticle (at protein level) (PubMed:11707440, PubMed:24829385). Expressed in germ cells, developing oocytes, sheath cells surrounding germ cells and oocytes, and in the eggshell (at protein level) (PubMed:11707440, PubMed:16857685).
messages: Lysosome
messages: RNAi-mediated knockdown causes early embryonic lethality with embryos arrested at the 100-200 cell stage (PubMed:11707440). The few larvae which survive have incomplete gut development and die at the L1 stage (PubMed:11707440). RNAi-mediated knockdown at the L3 larval stage causes a growth delay, adults are shorter and thinner, and lay fewer eggs (PubMed:11707440).
messages: Secreted
messages: phagosome

6239:CELE C12D8.8
gene id: 6239:CELE_C12D8.8
uniprot id: Q17939
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F19C6.5
gene id: 6239:CELE_F19C6.5
uniprot id: Q09308
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C56C10.1
gene id: 6239:CELE_C56C10.1
uniprot id: Q18891
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Broadly expressed in somatic tissues including the pharynx, intestine, spermatheca, and in coelomocytes (PubMed:27558849). Expressed in the lining of the gut lumen (PubMed:25273556).
messages: Early endosome
messages: Hermaphrodites exhibit sperm-specific sterility and only lay unfertilized eggs (PubMed:27558849). In contrast to wild-type animals, mutant males produce no or few spermatids in their gonads, but instead their gonads accumulate terminally arrested spermatocytes that do not bud and contain four haploid nuclei (PubMed:27558849). In some instances, the spermatocytes have small buds that do not form spermatids (PubMed:27558849). Oocytes and unfertilized eggs contain some larger endocytic structures tethered to yolk granules (PubMed:27558849). RNAi-mediated knockdown results in defective yolk uptake in oocytes with the appearance of endocytic structures containing yolk tethered to large membranous organelles which could be lysosomes (PubMed:25273556). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen which is possibly indicative of increased endosomal fusion activity, and defective trafficking of proteins such as lmp-1 to lysosomal compartments (PubMed:25273556). RNAi-mediated knockdown in a sand-1 mutant background results in defective endosome fusion with the formation of larger, irregularly-shaped rab-5 positive endosomes in oocytes and intestinal cells, and larger yolk-containing granules than in the sand-1 single mutant (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 results in defective protein trafficking to lysosomal compartments, and an irregular distribution of vesicles of various sizes throughout the gut cells (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 in a sand-1 mutant background rescues the large endosome phenotype and the defective protein trafficking to lysosomal compartments in the sand-1 single mutant, but results in lethality (PubMed:25273556).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:25273556). Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25273556). Most likely within the CORVET complex, it is involved in the fusion of endocytic compartments (PubMed:25273556). Required for sperm development and function (PubMed:19109425, PubMed:27558849).
messages: Probable core component of the class C core vacuole/endosome tethering (CORVET) complex. The common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, and which further associates with vps-8 and vps-33.2 (PubMed:25273556). Interacts with spe-39 (PubMed:19109425).
messages: Recycling endosome
messages: clathrin-coated vesicle

6239:CELE R12E2.10
gene id: 6239:CELE_R12E2.10
uniprot id: O61789
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition (PubMed:19879842, PubMed:19879147). Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization (PubMed:19879147). Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I (PubMed:19879842). Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization (PubMed:19879147).
messages: Part of a complex, consisting of pseudophosphatases egg-3, egg-4, egg-5 and kinase mbk-2; this complex is required for the oocyte-to-zygote transition. Interacts (via tyrosine-protein phosphatase domain) with kinase mbk-2 (via 'Tyr-619' and 'Tyr-621'); mbk-2 tyrosine phosphorylation enhances the interaction.
messages: Severe reduction in the number of hatched larvae (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 results in no viable progeny and causes endomitosis in the uterus, generation of polyspermic embryos and defects in meiosis completion, polar body formation and eggshell chitin layer formation (PubMed:19879147). In addition, posterior formation of F-actin cap at the cortex oocyte and its polarized dispersal after fertilization are impaired (PubMed:19879147). Prevents mbk-2 localization to the unfertilized oocyte cortex without affecting egg-3 cortical localization (PubMed:19879842, PubMed:19879147). Prevents mbk-2, egg-3 and chs-1 re-localization to cytoplasmic foci at meiosis anaphase I (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 and mel-26 causes premature phosphorylation of mei-1, a mbk-1 substrate, during oocyte maturation (PubMed:19879842).
messages: The active site Cys-600 is replaced by a Asp residue suggesting that egg-5 may lack catalytic activity. Despite the lack of catalytic activity, egg-5 may retain the capacity to bind to phosphorylated substrates.
messages: cell cortex

6239:CELE T28D9.2
gene id: 6239:CELE_T28D9.2
uniprot id: Q10021
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites.
messages: RNA-mediated interference (RNAi) of rsp-5/rsp-6 resulted in fertile animals that exhibit excessive sperm and delayed oocyte production, and sterile animals that develop morphological abnormalities of somatic gonads.

6239:CELE K11G12.2
gene id: 6239:CELE_K11G12.2
uniprot id: P48182
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Component of nicotinic acetylcholine receptor. In cholinergic motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3 alpha subunits unc-38, unc-63 and acr-12.
messages: Expressed from L1 larval stage through adults.
messages: Locomotion is slower. Moderately resistant to paralysis induced by acetylcholine esterase inhibitor aldicarb but sensitivity to acetylcholine agonist levamisole is normal. Reduced both cholinergic and GABAergic motoneuron activities characterized by a reduction in miniature postsynaptic currents in muscles.
messages: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:8581398, PubMed:20027209). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209, PubMed:23658528, PubMed:27782882).
messages: Postsynaptic cell membrane
messages: Specifically expressed in cholinergic ventral cord motoneurons of the VA, VB, DA and DB classes but not AS and VC classes. Expressed in PVQ and DVC neurons in the tail.

6239:CELE F35E8.1
gene id: 6239:CELE_F35E8.1
uniprot id: B6EU68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C46F4.1
gene id: 6239:CELE_C46F4.1
uniprot id: B8ZZ05
uniprot id: G5EFX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C04E12.5
gene id: 6239:CELE_C04E12.5
uniprot id: A0A131MBK3
uniprot id: O76676
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F58D5.1
gene id: 6239:CELE_F58D5.1
uniprot id: Q9NLD1
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE C49H3.1
gene id: 6239:CELE_C49H3.1
uniprot id: Q9GYQ4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed bilaterally in AFD sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:27062922). Regulates thermotaxis responses in AFD sensory neurons (PubMed:16415369, PubMed:21315599, PubMed:27062922). May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369, PubMed:21315599). Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3 (PubMed:27062922). cGMP levels antagonize the actin cytoskeleton regulator wsp-1 (PubMed:27062922).
messages: Inhibited by chloride with an IC(50) of 60 mM.
messages: The guanylate cyclase domain is required for thermotaxis responses.
messages: The protein kinase domain is predicted to be catalytically inactive. Might be required for the negative regulation of the guanylate cyclase domain (PubMed:27062922).
messages: cilium

6239:CELE F31E3.3
gene id: 6239:CELE_F31E3.3
uniprot id: P53016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).

6239:CELE B0336.6
gene id: 6239:CELE_B0336.6
uniprot id: Q10929
names: Similarity
messages: Belongs to the ABI family.

6239:CELE C05C12.3
gene id: 6239:CELE_C05C12.3
uniprot id: G5ECM4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK455.4
gene id: 6239:CELE_ZK455.4
uniprot id: Q23498
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Preferentially expressed in postembryonic development.
messages: Requires Zn(2+) to be fully active.
messages: Secreted
messages: Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin (N-acyl-sphingoid-1-phosphocholine) to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
messages: There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinases have been found in worms.

6239:CELE Y119C1B.4
gene id: 6239:CELE_Y119C1B.4
uniprot id: Q95Y83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Mitochondrion

6239:CELE Y46E12BL.1
gene id: 6239:CELE_Y46E12BL.1
uniprot id: Q965N9
names: Similarity
messages: Belongs to the TGF-beta family.

6239:CELE F13D11.4
gene id: 6239:CELE_F13D11.4
uniprot id: Q19391
names: Similarity
messages: Belongs to the 3-beta-HSD family.

6239:CELE C08B6.3
gene id: 6239:CELE_C08B6.3
uniprot id: N1NSH4
uniprot id: Q17815
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE ZK1251.2
gene id: 6239:CELE_ZK1251.2
uniprot id: H9G2S9
uniprot id: Q23430
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Insulin-like peptide which plays a role in ageing as a consequence of daf-16 activity.
messages: RNAi-mediated knockdown extends lifespan.
messages: Secreted

6239:CELE F44C4.3
gene id: 6239:CELE_F44C4.3
uniprot id: P43508
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Induced by ultraviolet and ionizing radiation through a cep-1-dependent mechanism.
messages: Mediates the radiation-induced bystander effect (RIBE), a process in which factors released by irradiated cells or tissues exert effects on unexposed cells or tissues. Following localized ultraviolet irradiation of the head, mediates RIBE in multiple unexposed regions including the posterior region. Also leads to RIBE including inhibition of cell death and increased embryonic lethality of progeny in unirradiated animals exposed to the culture medium of irradiated animals. Likely to exert RIBE by acting through the insulin-like receptor daf-2.
messages: Not detected in the embryo, observed in the intestine of early stage L1-L3 larvae, peaks at the L4 larval stage and declines in adulthood.
messages: RNAi-mediated knockdown results in greatly reduced radiation-induced bystander effect (RIBE) activity in the culture medium of irradiated animals.
messages: Secreted
messages: Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC.

6239:CELE F41C3.4
gene id: 6239:CELE_F41C3.4
uniprot id: Q20263
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Expressed widely during larval and adult stages.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex (By similarity). Involved in regulating AMsh glial cell size, acting by modulating the E3 ubiquitin ligase rnf-145/RNF145, probably by mediating the translocation of rnf-145 from the cis-Golgi to the trans-Golgi during development (PubMed:33370778).
messages: RNAi-mediated knockdown causes embryonic lethality, but about 10% of animals survive to early adulthood (PubMed:33370778). Significantly enlarged AMsh glial cells (PubMed:33370778).
messages: cis-Golgi network

6239:CELE F54D1.6
gene id: 6239:CELE_F54D1.6
uniprot id: Q20762
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T19D2.1
gene id: 6239:CELE_T19D2.1
uniprot id: A0A5A4YQ91
uniprot id: Q22580
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C17C3.8
gene id: 6239:CELE_C17C3.8
uniprot id: Q18053
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a homodimer binds DNA via the E-box sequence 5'-CACGTG-3' (PubMed:19632181). Represses lag-2 transcription during embryogenesis via Notch signaling, in an unc-37-dependent manner (PubMed:15935776). Also represses tbx-37 independent of Notch signaling (PubMed:15935776). In the intestine, plays a role in probiotic-mediated protection against infections by pathogens such as S.enterica (PubMed:35263319). This is most likely by positively regulating the expression of genes such as bar-1 upon exposure to probiotic bacteria such as the E.faecium (PubMed:35263319).
messages: Expressed in AB cell descendants in embryos.
messages: Expressed in intestinal cells (at protein level).
messages: Homodimer; binds to DNA as a homodimer.
messages: Nucleus
messages: RNAi-mediated knockdown in the intestine decreases the E.faecium-mediated protection against S. enterica infection (PubMed:35263319). RNAi-mediated knockdown reduces the expression of genes including bar-1 following E.faecium infection (PubMed:35263319). RNAi-mediated knockdown in the germline or the nervous system does not affect E.faecium-mediated protection against S.enterica infection (PubMed:35263319).

6239:CELE E01A2.3
gene id: 6239:CELE_E01A2.3
uniprot id: Q27886
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cell fate decisions disrupted, protein localization altered and neuron translocation disrupted. Defective tail development in males. Defective in egg laying in hermaphrodites. Nuclear localization of wrm-1 and lit-1 appears disrupted. Similar to tau-induced unc phenotype. Deviations in vulval precursor cell fate are observed when knocked down in conjunction with cwn-1 and egl-20. Bivulval phenotype when accompanied by mom-2 and/or cwn-2 knockdowns. Increase in ectopic synaptic vesicle puncta.
messages: Expressed during embryogenesis and larval development (PubMed:17719547, PubMed:7553861, PubMed:8026318). Mainly expressed in the tail during larval stages (PubMed:20711352).
messages: Expressed in the tail hypodermis.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis. Plays a role in motorneuron development by promoting the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PubMed:23376536). Positively regulates cilium position and dendrite morphogenesis in postembryonic PQR gas-sensing neurons (PubMed:33460640). This is likely through regulating the localization of grdn-1 to the distal dendrites of PQR sensory neurons (PubMed:33460640).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE C33H5.2
gene id: 6239:CELE_C33H5.2
uniprot id: Q18416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE T09H2.1
gene id: 6239:CELE_T09H2.1
uniprot id: O61935
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T28C12.2
gene id: 6239:CELE_T28C12.2
uniprot id: O16697
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F13E9.11
gene id: 6239:CELE_F13E9.11
uniprot id: K8ERZ3
uniprot id: K8ESG8
names: Similarity
messages: Belongs to the TMEM121 family.

6239:CELE F09B12.2
gene id: 6239:CELE_F09B12.2
uniprot id: O62144
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE Y116F11B.9
gene id: 6239:CELE_Y116F11B.9
uniprot id: Q9NEJ9
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F56F4.1
gene id: 6239:CELE_F56F4.1
uniprot id: A7DT35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE ZK384.3
gene id: 6239:CELE_ZK384.3
uniprot id: Q7JKL9
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE T24A6.11
gene id: 6239:CELE_T24A6.11
uniprot id: O61942
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F32A5.2
gene id: 6239:CELE_F32A5.2
uniprot id: H2KZ53
uniprot id: Q95QH5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C06A12.3
gene id: 6239:CELE_C06A12.3
uniprot id: D3YT87
uniprot id: D3YT88
uniprot id: Q9XU41
names: Similarity
messages: Belongs to the GSKIP family.

6239:CELE ZC434.6
gene id: 6239:CELE_ZC434.6
uniprot id: A5Z2T7
uniprot id: Q23316
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
messages: Membrane

6239:CELE H06I04.2
gene id: 6239:CELE_H06I04.2
uniprot id: A0A0K3AUV4
uniprot id: Q9N5N8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

6239:CELE C37E2.4
gene id: 6239:CELE_C37E2.4
uniprot id: Q93352
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed in ASE and AWC chemosensory neurons (PubMed:14536063, PubMed:15095973). Expressed left-right asymmetrically in the embryo, in the grandmother cell and the mother cell to the MI pharyngeal motorneuron but in neither analogous precursors of the e3D neuron (PubMed:21041366).
messages: Interacts with sox-2.
messages: Nucleus
messages: Probable transcription factor, acting as a progenitor identity factor regulating the development of lineally-related embryonic cells including glial, excretory and neuronal cells (PubMed:25738873, PubMed:21041366). Mediates chemosensory function of ASE and AWC neurons (PubMed:14536063, PubMed:15095973). In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons (PubMed:14536063, PubMed:15095973). Acts cell-autonomously to establish a neuronal left right asymmetry, possibly promoting asymmetric expression of the helix-loop-helix proteins ngn-1 and hlh-2 (PubMed:21041366). In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons (PubMed:26341465, PubMed:15095973). May regulate the expression of sox-2 in AWC olfactory neurons (PubMed:26341465).
messages: Up to the comma stage, expressed in six lineages that produce diverse cell types including pharyngeal cells, muscles, neurons and glia.

6239:CELE F29B9.10
gene id: 6239:CELE_F29B9.10
uniprot id: Q9GYI2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

6239:CELE Y54H5A.3
gene id: 6239:CELE_Y54H5A.3
uniprot id: Q9N394
names: Similarity
messages: Belongs to the RRM RBM42 family.

6239:CELE F10D2.11
gene id: 6239:CELE_F10D2.11
uniprot id: O16922
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C33F10.5
gene id: 6239:CELE_C33F10.5
uniprot id: H2KZ60
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in neurons including the I1 and I3 pharyngeal interneurons, NSM and VNC motor neurons, HSN and CAN neurons, the ALM and PLM touch receptor neurons and other unidentified head neurons (PubMed:23123963). Expressed in AVG interneurons (PubMed:28901288). Also expressed in somatic muscles, the excretory canal, the excretory cell and the hypodermis (PubMed:23123963).
messages: Expressed throughout embryonic development and adulthood.
messages: Interacts with sax-7; the interaction establishes synaptic connections between neurons.
messages: Perikaryon
messages: Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation (PubMed:23123963). By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons (PubMed:28901288). Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis (PubMed:23123963). Plays a role in regulating male mating behavior (PubMed:28901288).
messages: RNAi-mediated knockdown results in truncated or shorter excretory canals, and also truncated ALM axons that fail to extend above the nerve ring, truncated PLM processes and abnormal VNC axon patterning.
messages: Synapse
messages: axon

6239:CELE T07C12.9
gene id: 6239:CELE_T07C12.9
uniprot id: Q22279
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

6239:CELE Y53C12B.2
gene id: 6239:CELE_Y53C12B.2
uniprot id: O18216
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
messages: nucleolus

6239:CELE C34F6.3
gene id: 6239:CELE_C34F6.3
uniprot id: O17642
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C24A11.9
gene id: 6239:CELE_C24A11.9
uniprot id: P91093
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

6239:CELE C45H4.17
gene id: 6239:CELE_C45H4.17
uniprot id: A0A0M7RF95
uniprot id: O44706
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F20D1.1
gene id: 6239:CELE_F20D1.1
uniprot id: Q93533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane
messages: synaptic vesicle membrane

6239:CELE Y59C2A.1
gene id: 6239:CELE_Y59C2A.1
uniprot id: Q9TZC6
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE F31F4.7
gene id: 6239:CELE_F31F4.7
uniprot id: O17123
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M03B6.2
gene id: 6239:CELE_M03B6.2
uniprot id: Q93896
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y55F3BR.1
gene id: 6239:CELE_Y55F3BR.1
uniprot id: Q9N341
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

6239:CELE C45G3.5
gene id: 6239:CELE_C45G3.5
uniprot id: G5EF84
names: Function
names: Subcellular Location Annotation
messages: Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules.
messages: adherens junction
messages: hemidesmosome

6239:CELE W09C3.4
gene id: 6239:CELE_W09C3.4
uniprot id: P91529
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

6239:CELE ZK470.1
gene id: 6239:CELE_ZK470.1
uniprot id: Q23508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

6239:CELE T12A2.13
gene id: 6239:CELE_T12A2.13
uniprot id: P54128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F58G6.4
gene id: 6239:CELE_F58G6.4
uniprot id: A0A061ACH3
uniprot id: Q21005
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Expressed in a subset of cholinergic motor neurons including cholinergic motor neurons in the ventral cord, the retrovesicular ganglion and in head neurons such as the SMD, RMD motor neurons, the AVA and AVE command interneurons and the SAA neurons. Also expressed in a small number of glutamatergic neurons including the pharyngeal neurons MI and M3, the PLM neurons and a pair of neurons in the lateral ganglion.
messages: Grossly normal movement.
messages: Homopentamer (in vitro). Forms heteropentamers composed of acc-1 and acc-4 or acc-1 and acc-3. Both homopentamers and heteropentamers form functional ion channels.
messages: Membrane

6239:CELE ZK430.3
gene id: 6239:CELE_ZK430.3
uniprot id: Q27538
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

6239:CELE F26D2.13
gene id: 6239:CELE_F26D2.13
uniprot id: Q9XV59
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R05C11.1
gene id: 6239:CELE_R05C11.1
uniprot id: Q9TYQ0
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE ZK1010.2
gene id: 6239:CELE_ZK1010.2
uniprot id: G5EEZ0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

6239:CELE F10G7.4
gene id: 6239:CELE_F10G7.4
uniprot id: Q19325
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rad21 family.
messages: Chromosome
messages: Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle (PubMed:12827206, PubMed:12808038). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206, PubMed:12808038). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).
messages: Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their hinge domain, scc-1 which links them, and scc-3. Interacts with smc-1, smc-3, scc-3 and tim-1.
messages: Cytoplasm
messages: Expressed at high levels in actively dividing cells, during all stages of development.
messages: Nucleus
messages: Postembryonic RNAi-mediated knock-down results in either larval arrest, or adult sterility with a protruding vulva phenotype (PubMed:12808038, PubMed:12827206). Worms have defective chromosome segregation (PubMed:12808038).

6239:CELE C06A5.3
gene id: 6239:CELE_C06A5.3
uniprot id: H2KY56
uniprot id: Q5TYK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

6239:CELE C05D2.4
gene id: 6239:CELE_C05D2.4
uniprot id: H2KYG4
uniprot id: O45137
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE C53C7.1
gene id: 6239:CELE_C53C7.1
uniprot id: Q6EUU1
uniprot id: Q9XXU4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F31E8.4
gene id: 6239:CELE_F31E8.4
uniprot id: Q19936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Late endosome membrane
messages: Membrane

6239:CELE F01D4.2
gene id: 6239:CELE_F01D4.2
uniprot id: O17757
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F59E12.12
gene id: 6239:CELE_F59E12.12
uniprot id: O01904
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y65B4BR.5
gene id: 6239:CELE_Y65B4BR.5
uniprot id: Q86S66
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Cytoplasm
messages: May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).
messages: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity). Plays a role in the response to heat stress (PubMed:22957041).
messages: RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type.

6239:CELE T22H2.5
gene id: 6239:CELE_T22H2.5
uniprot id: G3MU68
uniprot id: O45799
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE F22B7.13
gene id: 6239:CELE_F22B7.13
uniprot id: Q95QJ7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122).
messages: Interacts with gpr-1, lin-5 and GDP-bound goa-1.
messages: Simultaneous RNAi-mediated knockdown of both gpr-1 and gpr-2 causes, in the 1-cell embryo, a decrease in nuclear and spindle movements during prophase, reduced asymmetric spindle elongation during anaphase and mispositioning of nuclei after cell division.
messages: cell cortex
messages: spindle

6239:CELE T27A1.6
gene id: 6239:CELE_T27A1.6
uniprot id: P90971
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: First expressed during embryogenesis at the 1.5-fold stage, and in very few cells throughout development (PubMed:10716947). Expressed in L1 larvae in the posterior hindgut cells B and F and in later L1 stage in the B daughter cells B.a and B.p (PubMed:10716947). Also expressed in two posterior hypodermal nuclei of the large syncytial cell hyp7 and in the nervous system in two neurons of the lumbar ganglion (PubMed:10716947).
messages: Nucleus
messages: RNAi-mediated knockdown by injection into the gonad results in male progeny with grossly abnormal tails with no spicules (PubMed:10716947). Hermaphrodite progeny are constipated and show backward uncoordination (PubMed:10716947).
messages: Transcription factor (PubMed:28056346). Involved in cell fate determination; required to pattern the posterior hindgut (PubMed:10716947). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346). Required throughout development to repress transcription by unc-3, probably acting by binding to specific promoter elements (PubMed:28056346). Represses expression of VA and VB motor neuron-specific effector genes, such as DEG/ENaC channel del-1 and the innexin inx-12, in DA and DB motor neurons (PubMed:28056346). Represses expression of transcription factor bnc-1, perhaps acting directly, in DA and DB motor neurons (PubMed:28056346).

6239:CELE B0416.1
gene id: 6239:CELE_B0416.1
uniprot id: A0A1N7SYS6
uniprot id: A0A1N7SYT6
uniprot id: A0A1N7SZ06
uniprot id: Q11069
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane
messages: Probable ion channel.

6239:CELE ZK892.4
gene id: 6239:CELE_ZK892.4
uniprot id: Q09618
names: Similarity
messages: Belongs to the CoA-transferase III family.

6239:CELE F25D1.4
gene id: 6239:CELE_F25D1.4
uniprot id: Q19777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F08F3.7
gene id: 6239:CELE_F08F3.7
uniprot id: Q27531
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F10B5.1
gene id: 6239:CELE_F10B5.1
uniprot id: Q09533
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).

6239:CELE R02E12.2
gene id: 6239:CELE_R02E12.2
uniprot id: Q21643
names: Similarity
messages: Belongs to the Mo25 family.

6239:CELE ZC155.3
gene id: 6239:CELE_ZC155.3
uniprot id: Q23243
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds non-specifically to DNA and forms static foci which grow by recruiting other morc-1 molecules, and thereby stimulates conformational changes and compaction of DNA, which appears to be enhanced by ATP-binding, but does not require ATP activity (PubMed:31442422). Preferentially binds to long DNAs (PubMed:31442422). Compacts and entraps segments of DNA by sequentially forming loops along the DNA, beginning at the free ends of single- and double-tethered DNA (PubMed:31442422). Does not extrude the DNA loops on compacted double-tethered DNA (PubMed:31442422). Involved in gene silencing (PubMed:22555433). Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes (PubMed:28535375). May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes (PubMed:28535375). Promotes transgenerational epigenetic inheritance and germline immortality (PubMed:28535375, PubMed:28533440).
messages: Expressed in germline and somatic cells.
messages: Mortal germline (Mrt) phenotype in which there is a progressive decline in fertility with each generation at 25 degrees Celsius culminating in complete sterility after five to six generations (PubMed:28535375, PubMed:28533440). Resistant to nuclear RNAi and defective RNAi inheritance (PubMed:28535375). Reduced trimethylation of 'Lys-9' of histone H3 at endogenous siRNA-directed targets, a small degree of irregularly localized heterochromatin, with 70% correctly localized, defective chromatin compaction in hermaphrodite X chromosomes (PubMed:28535375). Double knockout with the histone methyltransferase met-1 rescues the progressive germline mortality defect in the morc-1 single mutant (PubMed:28535375). RNAi-mediated knockdown results in defective gene silencing (PubMed:22555433).
messages: Nucleus
messages: Predominantly forms monomers and dimers, but multimerizes to form trimers and tetramers upon DNA binding.
messages: nuclear body

6239:CELE F11A3.2
gene id: 6239:CELE_F11A3.2
uniprot id: G5EFF9
uniprot id: G5EG28
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

6239:CELE Y56A3A.17
gene id: 6239:CELE_Y56A3A.17
uniprot id: Q7K6X4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nuclear pore complex (PubMed:24011592). Plays a direct role in nuclear protein import (By similarity). Required for anoxia-induced prophase arrest; may function in concert with cdk-1 to arrest prophase blastomeres in response to anoxia (PubMed:20053678).
messages: Interacts with importin beta imb-1 (PubMed:24011592). Interacts with DNA-directed RNA polymerase III subunit rpc-1 (PubMed:24011592). Interacts with TATA-box-binding protein tbp-1 (PubMed:24011592). Interacts with GTF3C5 homolog tftc-5 (PubMed:24011592). Interacts with GTF3C3 homolog tftc-3 (PubMed:24011592).
messages: Nucleus membrane
messages: nuclear pore complex

6239:CELE F56H11.1
gene id: 6239:CELE_F56H11.1
uniprot id: A0A061ACF5
uniprot id: A0A061ACI3
uniprot id: A0A061ADQ1
uniprot id: A0A061AIV4
uniprot id: A0A061AKL1
uniprot id: O77469
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although involved in the same pathway as gon-1 and mig-17, it is probably not cleaved by these metalloproteases.
messages: Belongs to the fibulin family.
messages: Expressed from late embryonic stage onwards.
messages: Expressed in head muscle cells, anterior and posterior intestinal cells (PubMed:15556862). Isoform a: Expressed in male and hermaphrodite gonad, anterior and posterior intestine and pharyngeal basement membranes, body-wall muscle, GLR cells, uterine attachment and mechanosensory neurons (PubMed:15556863, PubMed:16120639, PubMed:17043142). Isoform c: Expressed on ALM/PLM mechanosensory neuron attachments, in flexible tracks connecting the pharyngeal, body-wall-muscle basement membranes and in uterine attachments (PubMed:16120639).
messages: Gonads have short and swollen arms. Pharyngeal defects. Movement is lethargic.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639). During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704). Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038). Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704). Required for larval development (PubMed:17043142).
messages: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane
messages: extracellular matrix

6239:CELE F21D5.8
gene id: 6239:CELE_F21D5.8
uniprot id: Q19685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

6239:CELE R03C1.3
gene id: 6239:CELE_R03C1.3
uniprot id: G5EGE2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F17A2.12
gene id: 6239:CELE_F17A2.12
uniprot id: Q19509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE T21C9.4
gene id: 6239:CELE_T21C9.4
uniprot id: Q22640
names: Function
names: Similarity
names: Subunit
messages: Belongs to the E(R) family.
messages: Homodimer.
messages: May have a role in the cell cycle.

6239:CELE Y25C1A.5
gene id: 6239:CELE_Y25C1A.5
uniprot id: Q9TYL9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

6239:CELE T10B9.2
gene id: 6239:CELE_T10B9.2
uniprot id: Q27514
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE K10C2.1
gene id: 6239:CELE_K10C2.1
uniprot id: Q94269
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE C33C12.9
gene id: 6239:CELE_C33C12.9
uniprot id: O16582
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

6239:CELE F38E1.9
gene id: 6239:CELE_F38E1.9
uniprot id: Q20157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

6239:CELE T04B8.3
gene id: 6239:CELE_T04B8.3
uniprot id: O44847
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y48A6B.6
gene id: 6239:CELE_Y48A6B.6
uniprot id: Q9XXD1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Expressed in the cholinergic motor neuron DA9, mechanosensory neurons ALM and PLM, and the interneuron PVPL.
messages: Homotetramer or heterotetramer (Probable). Interacts with unc-101 (via N-terminus); which targets kvs-4 to dendrites (PubMed:26762178).
messages: Perikaryon
messages: The EQMIL and WNIIE motifs are required for dendritic localization.
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
messages: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.
messages: axon
messages: dendrite

6239:CELE C55B7.2
gene id: 6239:CELE_C55B7.2
uniprot id: Q9NDH7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 18 family.
messages: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides.
messages: Expressed in a complex subset of neurons in larvae and in the spermathecal and pharyngeal-intestinal valves and certain vulval cells of adults.
messages: Golgi apparatus membrane
messages: In embryos, expressed from the late comma stage.

6239:CELE M02B7.4
gene id: 6239:CELE_M02B7.4
uniprot id: U4PE03
uniprot id: U4PQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

6239:CELE C08A9.1
gene id: 6239:CELE_C08A9.1
uniprot id: P41977
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: By heat.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Expressed in pharynx and rectum. Upon thermal stress, expressed in vulva, body wall muscles and hypodermis.
messages: Homotetramer.
messages: Mitochondrion

6239:CELE F46G10.7
gene id: 6239:CELE_F46G10.7
uniprot id: Q20480
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expression is first detected at the three-fold stage during embryogenesis.
messages: Interacts with pyc-1, pcca-1 and mccc-1.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance (PubMed:23438705).
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
messages: Ubiquitously expressed with high expression in the pharynx, body wall muscles and gonad.

6239:CELE T22A3.4
gene id: 6239:CELE_T22A3.4
uniprot id: Q8I4F7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
messages: Expressed in pharyngeal and body wall muscles.
messages: Histone methyltransferase (PubMed:29514099). Specifically methylates 'Lys-36' of histone H3, inducing di-methylation (PubMed:29514099). Plays a role in modulating lifespan and oxidative stress resistance, in a manner dependent upon daf-16/Forkhead box protein O and the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29514099). Represses transcription of daf-16 isoform a, perhaps by methylating histone H3 at the daf-16 promoter, which in turn leads to recruitment of histone deacetylases and thus modulation of expression (PubMed:29514099).
messages: Muscle-specific expression increases in adults between day 3 and day 11.
messages: RNAi-mediated knockdown causes lifespan extension.

6239:CELE B0280.9
gene id: 6239:CELE_B0280.9
uniprot id: P42000
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

6239:CELE F56C11.1
gene id: 6239:CELE_F56C11.1
uniprot id: O61213
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in hypodermal cells.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Interacts with doxa-1 and tsp-15 (PubMed:23028364). Interacts with rho-1 (PubMed:28085666).
messages: Membrane
messages: Peroxidase activity is inhibited by aminobenzohydrazide.
messages: Plays a role in cuticle biogenesis (PubMed:11514595, PubMed:19406744, PubMed:23028364, PubMed:25480962, PubMed:18460651). In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix (PubMed:11514595, PubMed:19406744, PubMed:23028364). May regulate the production of ROS by playing a role in modulating proline catabolism (PubMed:27974198). Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens (PubMed:19406744). Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity (PubMed:28085666).
messages: RNAi-mediated knockdown results in a blistered cuticle phenotype (PubMed:23028364, PubMed:25480962). Resistant to iodide toxicity (PubMed:25480962). RNAi-mediated knockdown in combination with proline supplementation suppresses the effects of exogenous proline alone and increases reactive oxygen species production and reduces the expression of skn-1 transcriptional targets including gst-4 following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown rescues the enhanced longevity and increased reactive oxygen species production defects in memo-1 mutants (PubMed:28085666). RNAi-mediated knockdown suppresses the nuclear localization of transcription factor skn-1 in memo-1 RNAi mutants (PubMed:28085666).

6239:CELE Y94H6A.7
gene id: 6239:CELE_Y94H6A.7
uniprot id: A7WK41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

6239:CELE Y48A5A.3
gene id: 6239:CELE_Y48A5A.3
uniprot id: G4SP89
names: Subcellular Location Annotation
messages: Mitochondrion

6239:CELE Y60A3A.1
gene id: 6239:CELE_Y60A3A.1
uniprot id: Q23023
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: During embryonic development unc-51 is expressed extensively, particularly in the head region of late embryos. In the larval stages, expression appears to be restricted to neurons.
messages: Interacts with unc-14 and vab-8 (PubMed:15539493). Interacts (via C-terminus) with atg-13 (PubMed:19377305). Interacts (via the LIR motif) with lgg-1; the interaction is direct (PubMed:26687600).
messages: Protein kinase important for axonal elongation and axonal guidance (PubMed:7958904, PubMed:15539493). Functions in the CAN axons to direct both anterior and posterior migrations (PubMed:15539493). Phosphorylates both unc-14 and vab-8 (PubMed:15539493). Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation (PubMed:12958363, PubMed:17890369, PubMed:19377305, PubMed:26687600). Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells (PubMed:19377305). Plays a role in mitophagy during limited food availability (PubMed:30133321). Regulates cell size (PubMed:17890369). Plays a role in male tail ray pattern formation (PubMed:17890369). May be required for normal dauer morphogenesis (PubMed:12958363).
messages: The LIR motif (LC3-interacting region) is required for its interaction with lgg-1.
messages: Worms exhibit various abnormalities in axonal elongation and axonal structures (PubMed:7958904). RNAi-mediated knockdown causes abnormalities in constitutive dauer formation in daf-2 e1370 mutant including a lack of autophagosome formation (PubMed:12958363).

6239:CELE T28A8.7
gene id: 6239:CELE_T28A8.7
uniprot id: Q9XU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

6239:CELE H22K11.2
gene id: 6239:CELE_H22K11.2
uniprot id: O76632
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

6239:CELE ZK973.6
gene id: 6239:CELE_ZK973.6
uniprot id: Q9N4M4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nesprin family.
messages: First expressed in L1 larvae, and thereafter throughout adulthood.
messages: Interacts with F-actin via its N-terminal domain. Most likely interacts with unc-84; the interaction is probably required to recruit anc-1 to the nuclear envelope.
messages: Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles.
messages: Nucleus outer membrane
messages: Plays a central role in nuclear and mitochondrial anchoring (PubMed:12169658, PubMed:6889924, PubMed:10375507, PubMed:22298703). Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus (PubMed:15773756). Has a role in positioning of the cell body of the PVQ lumbar interneuron (PubMed:22298703).
messages: The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.
messages: The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawaii (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extend more than 0.5 micrometers.
messages: Ubiquitously expressed in all postembryonic cells.
messages: cytoskeleton

6239:CELE F58A4.5
gene id: 6239:CELE_F58A4.5
uniprot id: P34472
names: Subcellular Location Annotation
messages: Secreted

6239:CELE Y113G7A.5
gene id: 6239:CELE_Y113G7A.5
uniprot id: G5EEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F02E9.4
gene id: 6239:CELE_F02E9.4
uniprot id: A5JYW9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Interacts with ztf-11; the interaction is weak (PubMed:31386623). Interacts with cfp-1 (PubMed:31602465).
messages: Expressed from the L1 stage of larval development to adulthood.
messages: Expressed in all ray structural cells including ray 6, 7, 8 and 9 of the male tail. Also expressed in the inner labial neurons, socket cells, the cephalic neurons in the head and the ventral nerve cord.
messages: Nucleus
messages: Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status (PubMed:21909284). Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC) (PubMed:17506990).
messages: Uncoordinated movement, protruding vulva and ray fusion defects in the male tail (PubMed:17506990). RNAi-mediated knockdown results in sterility (PubMed:16710447). RNAi-mediated knockdown in a him-8 mutant background results in no deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (PubMed:21909284).

6239:CELE F18A11.3
gene id: 6239:CELE_F18A11.3
uniprot id: O01323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0729 family.
messages: Cell membrane

6239:CELE ZK1098.8
gene id: 6239:CELE_ZK1098.8
uniprot id: P34607
names: Function
names: Similarity
messages: Belongs to the mut-7 family.
messages: Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.

6239:CELE F49E8.3
gene id: 6239:CELE_F49E8.3
uniprot id: Q4TT88
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aminopeptidase (PubMed:12930831). Required for the exit from meiosis, probably upstream of cyclin cyb-3 (PubMed:17021038). Involved in the establishment of the anterior-posterior polarity at the embryonic 1-cell stage by regulating the dynamics of sperm-donated centrosomes (PubMed:17021038, PubMed:20599902, PubMed:28065742). Plays a role in oocyte maturation (PubMed:24663498). Required for embryonic development (PubMed:12930831).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit. Can also use Ni(2+) and Co(2+) (PubMed:12930831).
messages: Chromosome
messages: Cytoplasm
messages: Expressed in the 1-cell embryos (at protein level) (PubMed:20599902). Expressed during gastrulation and throughout the larval stage and in adults (PubMed:12930831).
messages: Expressed mainly in intestinal cells in the posterior part of the intestine and in amphid sensory neurons and nerve ring neurons (PubMed:12930831). Expressed in neurons in the male tail (PubMed:12930831). Expressed in mature spermatids (at protein level) (PubMed:20599902).
messages: Inhibited by chelating agent 1,10-phenanthroline, aminopeptidase inhibitors actinonin, amastatin, and leuhistin, and to a lesser extent by puromycin.
messages: RNAi-mediated knockdown causes an arrest at the gastrulation stage in 30 percent of embryos (PubMed:12930831). The surviving adults lay a substantial number of unfertilized oocytes (PubMed:12930831). However, brood size is only slightly reduced (PubMed:24663498). In the gonads, the pachytene zone is expanded in 15 percent of animals and oocyte nucleolus disassembly is delayed (PubMed:24663498). Mutant 1-cell embryos have a delay in meiotic exit during which chromosomes fail to decondense after polar body extrusion and oocyte and sperm pronuclear envelope formation is delayed (PubMed:17021038). In addition, 33 percent of 1-cell embryos have impaired chromosome segregation at meiotic anaphase II (PubMed:17021038). During meiotic exit delay, sperm pronucleus/centrosome complex (SPCC) dissociates prematurely from the posterior cortex resulting in a failure to establish anterior-posterior polarity subsequently leading to a symmetric division in half of the 1-cell embryos (PubMed:17021038, PubMed:20599902, PubMed:28065742). Premature microtubule nucleation prior to the sperm pronuclear appearance occurs (PubMed:17021038, PubMed:20599902). Cortical flows, pseudocleavage and asymmetric localization of par-1, par-2, par-3 and par-6 are absent, and cytoplasmic P granules and pie-1 are mislocalized prior to the first mitotic division (PubMed:17021038, PubMed:20599902, PubMed:28065742). In addition, non-muscle myosin nmy-2 foci fails to clear from the posterior part during polarization in half of the 1-cell embryos (PubMed:28065742). Simultaneous RNAi-mediated knockdown of cyclin cyb-3, causes a failure to extrude the second polar body and prevents anaphase entry in some of the 1-cel embryos (PubMed:17021038). Also restores normal timing for meiotic exit but not the establishment of AP axis polarity (PubMed:17021038). Simultaneous RNAi-mediated knockdown of dynein heavy chain dhc-1, restores anterior-posterior polarity, par-1, par2 and par-6 asymmetric localization and pseudocl…
messages: cell cortex
messages: spindle pole

6239:CELE Y54G9A.6
gene id: 6239:CELE_Y54G9A.6
uniprot id: Q9XWH0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BUB3 family.
messages: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments (PubMed:18248670, PubMed:19109417, PubMed:25987605). Promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Necessary for expression and kinetochore localization of bub-1 (PubMed:19109417, PubMed:25987605). Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis (PubMed:26483555).
messages: May interact with bub-1; for localization at the kinetochore and the onset of anaphase.
messages: Nucleus
messages: Viable, but with a reduced brood size (PubMed:25987605). Reduced bub-1 expression and localization at the kinetochore which may lead to the delay in the onset of anaphase during embryogenesis (PubMed:25987605). Defective synapsis with increased numbers of nuclei that contain asymmetrically aligned (clustered) chromosomes (PubMed:26483555). RNAi-mediated knockdown results in reduced survival as compared to wild-type animals in anoxic conditions (PubMed:18248670).
messages: kinetochore

6239:CELE T28F3.3
gene id: 6239:CELE_T28F3.3
uniprot id: Q9XUC4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: By cholesterol.
messages: Highly expressed in developing spermatids (at the protein level) (PubMed:29879108). Expressed in the germline (PubMed:29879108).
messages: Membrane
messages: Reduced brood size, but the majority of hermaphrodites are sterile and lay a large number of unfertilized oocytes (PubMed:29879108). Defective spermatid activation (PubMed:29879108). Double knockout with spe-4 results in failed spermatocyte division (PubMed:29879108). Double knockout with spe-6 results in suppression of the premature spermatid activation phenotype of the single spe-6 (hc163) mutant (PubMed:29879108).
messages: Zinc transporter which regulates intracellular zinc levels (PubMed:29879108). Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function (PubMed:29879108). Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm (PubMed:29879108). The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization (PubMed:29879108).

6239:CELE T14G10.3
gene id: 6239:CELE_T14G10.3
uniprot id: Q22500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C27H6.2
gene id: 6239:CELE_C27H6.2
uniprot id: O17607
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Expressed in gonadal cells.
messages: Expressed in most cells of the early embryo. From the two-cell stage until late embryogenesis, expression is restricted to pharyngeal cells. Detected in two intestinal cells during the larval stage.
messages: Forms homohexameric rings. May form a dodecamer with ruvb-2 made of two stacked hexameric rings.
messages: Nucleus
messages: Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce-Tor signaling pathway whereby it is required for the accumulation and localization of box C/D snoRNP to nucleoli to regulate ribosomal maturation and thus protein synthesis (PubMed:18804378). Antagonizes the transcriptional activity of transcription factor pha-4, to control postembryonic development and adult longevity (PubMed:17720918, PubMed:18804378). Has a role in pharyngeal development (PubMed:17720918). Has a role in gonadal development (PubMed:25437307).
messages: RNAi-mediated knockdown results in arrest at larval stage L3, with less than 40% forming a mature vulva, lipid accumulation, epidermal granule formation and reduced protein synthesis (PubMed:17720918, PubMed:18804378). There is also gonadal detachment during gonad migration (PubMed:25437307).

6239:CELE T21C9.3
gene id: 6239:CELE_T21C9.3
uniprot id: Q8MPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F58F12.1
gene id: 6239:CELE_F58F12.1
uniprot id: Q09544
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element (Probable).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE H35B03.2
gene id: 6239:CELE_H35B03.2
uniprot id: V6CJB4
uniprot id: V6CKG6
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

6239:CELE F53H1.3
gene id: 6239:CELE_F53H1.3
uniprot id: O45074
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

6239:CELE VW02B12L.3
gene id: 6239:CELE_VW02B12L.3
uniprot id: Q9XXA2
names: Similarity
messages: Belongs to the MAPRE family.

6239:CELE C39F7.2
gene id: 6239:CELE_C39F7.2
uniprot id: B1GRL4
uniprot id: Q9UAQ3
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE Y41C4A.4
gene id: 6239:CELE_Y41C4A.4
uniprot id: Q9U2I0
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family.
messages: Defects in associative long-term memory (LTM) formation.
messages: Expressed widely, including in head neurons AFD, gustatory neurons ASE, the olfactory neurons AWC, and in the ASI sensory neurons, as well as in the intestine and gonads in hermaphrodites.
messages: Interacts with CREB-regulated transcription coactivator homolog crtc-1.
messages: Nucleus
messages: Plays a role in associative long-term memory (LTM) and learning.
messages: Plays a role in associative long-term memory (LTM) and learning; perhaps required at the time of acquisition and/or the consolidation phase of memory formation.
messages: RNAi-mediated knockdown positively modulates lifespan.
messages: Transcription factor (PubMed:12231504, PubMed:21331044). Transcriptional activity probably positively regulated by phosphorylation (PubMed:12231504, PubMed:27720609). Modulates expression of target genes, acting by binding to regulatory cAMP response elements (CRE) (PubMed:27720609, PubMed:12231504, PubMed:34260587). Acts downstream of the calcium-triggered CaMKK-CaMK1 signaling cascade, consisting of the protein kinase kinase ckk-1 and the protein kinase cmk-1 (PubMed:12231504, PubMed:27720609). Plays a role in learning and memory, feeding behavior, stress response, entry into the dauer stage and modulation of lifespan (PubMed:31413073, PubMed:21331044, PubMed:19035344, PubMed:27720609, PubMed:23013276, PubMed:34260587). Involved in commitment to the developmentally arrested larval state known as dauer, acting by positively regulating the expression of dauer-inhibiting TGF-beta-like daf-7 in the ASI neurons (PubMed:34260587). Plays a role in both associative and non-associative long-term memory (LTM) (PubMed:23013276, PubMed:31413073). Involved in modulating feeding behavior, acting by regulating transcription of tryptophan hydroxylase tph-1 in serotonergic ADF neurons (PubMed:19035344). Regulates transcription of genes involved in endoplasmic reticulum (ER) stress (PubMed:21331044). Involved in modulation of lifespan, in response to raised temperature, but independently of the heat-shock response pathway, acting by regulating transcription of FMRFamide-like neuropeptides flp-6 in the AFD neuron (PubMed:27720609, PubMed:21331044).
messages: Transcriptional activity is enhanced by phosphorylation (PubMed:12231504). Phosphorylated by cmk-1 (PubMed:12231504, PubMed:27720609).

6239:CELE K08C7.3
gene id: 6239:CELE_K08C7.3
uniprot id: A0A061AD21
uniprot id: A0A061AJI9
uniprot id: C1P640
uniprot id: C1P641
uniprot id: G5EEV6
uniprot id: Q21313
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required to assemble a stable basement membrane and for organizing receptor complexes and cytoskeletal components to the proper cell surfaces (PubMed:12783803). During embryogenesis, does not require the presence of collagen type IV in order to associate with cell surfaces, prior to assembly of the prototypical basement membrane (PubMed:12783803). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3 (PubMed:16495308). Probably plays a distinct role from the related laminin subunit alpha lam-3 (PubMed:12783803).
messages: First expressed between primary tissue layers near the end of gastrulation, at the 28-cell stage (at protein level) (PubMed:12783803). Detectable in all the major basement membranes during the remainder of embryogenesis, throughout larval development and in the adult (at protein level) (PubMed:12783803). Less expression in the basement membranes surrounding pharynx, intestine, body wall muscle and epidermis, and higher in the basement membranes surrounding gonad, distal tip cell, vulval muscle, intestinal muscle, anal depressor muscle and coelomocytes (at protein level) (PubMed:12783803). Earliest gene expression in cells that are ingressing through a furrow along the ventral midline (PubMed:12783803).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks detectable epi-1, but has no effect on tissue localization of laminin subunit alpha lam-3 (PubMed:12783803). Sterility (PubMed:12783803). Disrupted basement membrane integrity around body wall muscles, epidermis, gonad, intestine, and nerves (PubMed:12783803). Abnormal cell polarity, such that apical and basal features are poorly organized (PubMed:12783803). RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). Simultaneous knockdown of laminin subunit alpha lam-3 increases likelihood of arrest during embryogenesis (PubMed:12783803).
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: Secreted
messages: Tissue-specific expression of the laminin alpha subunits lam-3 and epi-1 begins early, before or as organogenesis proceeds; furthermore, the tissue localization of the two alpha subunits are independent.
messages: basement membrane
messages: extracellular matrix
messages: extracellular space

6239:CELE F40A3.2
gene id: 6239:CELE_F40A3.2
uniprot id: O16265
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y106G6E.4
gene id: 6239:CELE_Y106G6E.4
uniprot id: Q9XWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
messages: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).
messages: Cytoplasm
messages: Monomer.

6239:CELE T12A2.1
gene id: 6239:CELE_T12A2.1
uniprot id: Q22419
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

6239:CELE F32A7.3
gene id: 6239:CELE_F32A7.3
uniprot id: Q9XU98
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a receptor for slt-1 (PubMed:17901337). Required for the guidance of the AVM pioneer axon to the ventral nerve cord (PubMed:17901337). Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline (PubMed:25122090).
messages: Belongs to the EVA1 family.
messages: Cell membrane
messages: Interacts with sax-3 (PubMed:17901337). Interacts with slt-1 (PubMed:17901337, PubMed:25122090). Interacts (via the SUEL-type lectin domain) with madd-4 (PubMed:25122090). Interacts (via the transmembrane domain) with unc-40 (PubMed:25122090).
messages: The SUEL-type lectin domain, the transmembrane domain and the C-terminal region are required for the guidance of the muscle arm extensions to the midline neurons.
messages: Widely expressed in the developing nervous system during the period of embryogenesis. In first-larval-stage animals, strong expression is observed in ventral and dorsal nerve cords and in the PVM neurons but not in the AVM neurons.

6239:CELE Y108G3AL.1
gene id: 6239:CELE_Y108G3AL.1
uniprot id: A0A0K3ASX8
uniprot id: A0A0K3AY70
uniprot id: Q17391
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cullin family.
messages: Cytoplasm
messages: Highest levels in embryos and lower levels in larvae and adults.
messages: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
messages: Nucleus
messages: Probable component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes formed by cul-3, rbx-1 and a variable BTB domain-containing protein acting as both, adapter to cullin and substrate recognition component (PubMed:13679922). Interacts with bath-15, bath-40, bath-41, bath-42, C17F4.8, tag-303, D2045.8, F57C2.1, ZC239.15 and B0281.5 (PubMed:13679922). Interacts with mel-26 (via BTB domain) (PubMed:13679922, PubMed:22621901). Interacts with dcn-1 (PubMed:13679922).
messages: Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:13679922). Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:13679922). Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation (PubMed:12781129). Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation (PubMed:12781129). Regulates microtubule stability in the early embryo (PubMed:12781129). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of microtubule severing protein mei-1 downstream of unc-89 (PubMed:22621901). Together with spop-1, may promote the ubiquitination and proteasomal degradation of target bromodomain-containing proteins such as bet-1 (PubMed:34593637).
messages: RNAi-mediated knockdown at L1 larval stage results in the disorganization of myosin thick filaments in adult body wall muscles characterized by the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A-bands (PubMed:22621901). RNAi-mediated knockdown suppresses the age-dependent paralysis and growth arrest induced by exogenous dipeptide repeat protein PR50 (PubMed:34593637).

6239:CELE C39E9.14
gene id: 6239:CELE_C39E9.14
uniprot id: G5ECK7
uniprot id: G5ED34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

6239:CELE Y110A7A.11
gene id: 6239:CELE_Y110A7A.11
uniprot id: Q9N598
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

6239:CELE T03F1.7
gene id: 6239:CELE_T03F1.7
uniprot id: P91424
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Mitochondrion
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Stimulates transcription independently of the methyltransferase activity (By similarity).

6239:CELE T04A8.10
gene id: 6239:CELE_T04A8.10
uniprot id: Q22139
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F41B5.10
gene id: 6239:CELE_F41B5.10
uniprot id: O16677
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F38B6.6
gene id: 6239:CELE_F38B6.6
uniprot id: Q20144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

6239:CELE F23B2.4
gene id: 6239:CELE_F23B2.4
uniprot id: G5EFW7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:28479320). Plays a role in chemotaxis and sensory perception (PubMed:7240452, PubMed:7705621). Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41 (PubMed:7240452, PubMed:23284299, PubMed:25830239). Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa (PubMed:23284299).
messages: Sterile. Defective chemotaxis with 86% of mutants exhibiting reduced tracking to the chemoattractant ammonium chloride.
messages: cilium

6239:CELE F28C10.3
gene id: 6239:CELE_F28C10.3
uniprot id: Q19858
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE Y54E10A.15
gene id: 6239:CELE_Y54E10A.15
uniprot id: Q86S68
names: Similarity
messages: Belongs to the Cdt1 family.

6239:CELE T02G5.8
gene id: 6239:CELE_T02G5.8
uniprot id: Q22100
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Animals have a shortened lifespan and exhibit early behavioral decline characterized by the premature onset of uncoordinated locomotion and paralysis.
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Expressed in intestine from late embryogenesis onwards, and in the body wall muscle and pharynx from L2 onwards.
messages: Mitochondrion
messages: Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin (PubMed:24204312). Acts downstream of sir-2.1 to regulate aging and stress resistance (PubMed:20956318).

6239:CELE D1007.12
gene id: 6239:CELE_D1007.12
uniprot id: O01868
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

6239:CELE T22F3.11
gene id: 6239:CELE_T22F3.11
uniprot id: Q94307
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R02D3.3
gene id: 6239:CELE_R02D3.3
uniprot id: O44499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

6239:CELE F52A8.2
gene id: 6239:CELE_F52A8.2
uniprot id: Q20636
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16 (PubMed:11333232).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in regulating dopamine-mediated locomotion behavior (PubMed:15378064).

6239:CELE F23H12.6
gene id: 6239:CELE_F23H12.6
uniprot id: Q19768
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed bilaterally in RIM interneurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE Y54F10AM.2
gene id: 6239:CELE_Y54F10AM.2
uniprot id: Q9BKZ9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Embryonic lethality or larval arrest (PubMed:11896189, PubMed:15355315). Heterozygous animals are viable and display increased pharyngeal pumping rates associated with reduced acetylcholinesterase activity (PubMed:11896189, PubMed:15355315).
messages: Expressed in the pharynx (including pharyngeal muscle and nerve cells), ventral nerve cord and tail neurons.
messages: Expressed in the pharynx from three-fold stage embryos to adulthood.
messages: Interacts (via PID 2 domain) with apl-1 (via cytoplasmic domain).
messages: Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:11896189, PubMed:15355315).
messages: Phosphorylated.
messages: cytoskeleton

6239:CELE T20G5.2
gene id: 6239:CELE_T20G5.2
uniprot id: P34575
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Mitochondrion matrix

6239:CELE T24B8.1
gene id: 6239:CELE_T24B8.1
uniprot id: B7WN95
uniprot id: Q22716
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

6239:CELE C01C7.1
gene id: 6239:CELE_C01C7.1
uniprot id: G5EBZ8
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Probable tyrosine protein kinase which plays a role in vulva development, probably by acting as a negative regulator of the let-23/EGFR and let-60/ras pathway. Involved in the negative regulation of germline development (PubMed:14657502).
messages: RNAi-mediated knockdown in a gap-1 mutant background causes a hyperinduction of the vulva in 60 percent of animals (PubMed:10949028). In addition, suppresses the slow germline development of clk-1 mutants (PubMed:14657502).

6239:CELE R06B9.4
gene id: 6239:CELE_R06B9.4
uniprot id: O17983
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C16C8.2
gene id: 6239:CELE_C16C8.2
uniprot id: P91060
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y25C1A.10
gene id: 6239:CELE_Y25C1A.10
uniprot id: Q9TYL7
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F58H1.3
gene id: 6239:CELE_F58H1.3
uniprot id: Q21012
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

6239:CELE W08D2.4
gene id: 6239:CELE_W08D2.4
uniprot id: Q23221
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Can function as a Delta(6) fatty acid desaturase. Introduces a double bond in the fatty acid chain 6 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a variety of substrates such as linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, C18:2n-6) and alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, C18:3n-3) to produce gamma-linolenoyl-CoA ((6Z,9Z,12Z)-octadecatrienoyl-CoA, C18:3n-6) and (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA (18:4n-3) respectively (PubMed:9480865, PubMed:11972048). Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses (PubMed:18094048).
messages: HPO-19 and T05H4.4 are cytochrome b5 reductases required for PUFA desaturation in Caenorhabditis elegans. HPO-19 and T05H4.4 knockdown or mutation alter FAT-3 desaturase activity.
messages: Membrane
messages: The fat-3 mutants lack detectable Delta6-unsaturated fatty acids and have decreased C20 fatty acids levels, these animals require an additional day of development before commencing egg laying (PubMed:11972048). Impaired synaptic vesicle (SV) recycling characterized by the presence of enlarged SV and the formation of abnormal endocytic membrane-bound structures at synapses. The number of SVs is reduced by 37 percent although SV production in neuron cell body and their transport to release sites are normal (PubMed:18094048).

6239:CELE T19E7.5
gene id: 6239:CELE_T19E7.5
uniprot id: Q22594
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y43F4B.6
gene id: 6239:CELE_Y43F4B.6
uniprot id: O45935
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Chromosome
messages: Expressed in embryos.
messages: Expressed in the gonad.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryos that undergo early mitotic divisions as in wild-type, but which later then display aberrant patterns of nuclei and arrest before morphogenesis (PubMed:15452142). RNAi-mediated knockdown results in chromosome segregation defects in mitotic embryos whereby chromosomes form a disordered metaphase plate and multiple chromosomes exhibit delays in segregation resulting in the formation of bridges during anaphase (PubMed:15452142). The chromosome bridges stretch, break and sometimes form micronuclei (PubMed:15452142). RNAi-mediated knockdown results in kinetochore orientation defects in anaphase spindles in embryos in which kinetochores do not align on the spindle and some kinetochores stretch across the spindle interzone, parallel to the pole-pole axis (PubMed:15452142). RNAi-mediated knockdown does not cause defects in spindle architecture or cytokinesis in embryos (PubMed:15452142).
messages: Required for chromosome movement and orientation on spindle poles in mitosis and meiosis (PubMed:15452142). May play a role in early anterior-posterior chromosome movement in mitotic embryos (PubMed:15452142).
messages: nucleoplasm
messages: spindle

6239:CELE F52F12.6
gene id: 6239:CELE_F52F12.6
uniprot id: O02274
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MYT1 family.
messages: Expressed throughout embryonic development, but rarely expressed in lineages that do not produce neurons (PubMed:31386623). First expressed in neural precursors at the mid-gastrula stage of embryogenesis (PubMed:31386623). Highly expressed during the late gastrula to lima-bean embryonic stages, but weakly expressed in subsequent embryonic stages (PubMed:31386623). Post hatching, expressed in few neuronal nuclei and transiently expressed in postembryonic neuroectoblasts (PubMed:31386623). Not expressed in postmitotic neurons (PubMed:31386623). In L1 larvae, expressed in neurons and glia, but not in non-neuronal precursors (PubMed:31386623). In L2 stage larvae, expressed in the rectal epithelial Y cell (PubMed:31386623).
messages: Interacts with MuvB corepressor complex components lin-9, lin-52 and rba-1; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623). Interacts with sin-3; the interaction is weak (PubMed:31386623).
messages: Knockout in the rectal epithelial Y cell results in impaired formation of the PDA motor neuron (PubMed:31386623). Knockout in Pn lineages (the precursor cells of the ventral epidermis of newly hatched animals) results in the defective formation of ventral cord motor neurons (PubMed:31386623).
messages: Nucleus
messages: Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis (PubMed:31386623). Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623). Required for the generation of postembryonic neurons from epidermal cells (PubMed:31386623).

6239:CELE F11A10.4
gene id: 6239:CELE_F11A10.4
uniprot id: Q19338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON2 family.
messages: Golgi apparatus
messages: May be required for traffic between late Golgi and early endosomes.

6239:CELE F54C8.1
gene id: 6239:CELE_F54C8.1
uniprot id: P34439
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Homodimer.
messages: Mitochondrion matrix

6239:CELE F29A7.6
gene id: 6239:CELE_F29A7.6
uniprot id: O16207
names: Similarity
messages: Belongs to the MPP6 family.

6239:CELE B0495.9
gene id: 6239:CELE_B0495.9
uniprot id: Q09218
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F27D4.4
gene id: 6239:CELE_F27D4.4
uniprot id: Q93618
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

6239:CELE W08E12.1
gene id: 6239:CELE_W08E12.1
uniprot id: Q9N5A8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: By exposure to the Gram-negative bacterium P.aeruginosa strain PA14.
messages: Expressed in intestine, pharynx, and hypodermis at larval stage L4.
messages: Interacts with CCAAT/enhancer-binding protein cebp-2.
messages: Nucleus
messages: RNAi-mediated knockdown targeted to the intestine, but not to neurons, hypodermis, muscle or germline, reduced the resistance to infection by the Gram-positive bacterium P.aeruginosa strain PA14 (PubMed:34804026). Reduces expression of pmk-1 pathway dependent genes, such as systemic stress signaling mediator sysm-1 and infection response gene irg-4 (PubMed:34804026).
messages: Transcription factor (By similarity). Involved in modulating innate immune response pathways, acting to promote resistance against infection by Gram-negative bacterium P.aeruginosa strain PA14 (PubMed:34804026). May act as part of a feedback regulatory loop with the pmk-1/p38 MAPK pathway (PubMed:34804026). May also function in concert with CCAAT/enhancer-binding protein cebp-2 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026).

6239:CELE F15A2.1
gene id: 6239:CELE_F15A2.1
uniprot id: I2HA94
uniprot id: Q19470
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K06B4.6
gene id: 6239:CELE_K06B4.6
uniprot id: O17930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C47E12.4
gene id: 6239:CELE_C47E12.4
uniprot id: Q18680
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Plays a role in intestinal development and subsequent normal secretory, digestive and absorption functions. Required for larval development.
messages: Cytoplasm
messages: Expressed from the embryonic stage of development to adulthood.
messages: Expressed in coelomocytes, the intestine and in the nervous system including the nerve cords and sensory neurons.

6239:CELE W01A8.8
gene id: 6239:CELE_W01A8.8
uniprot id: A0A0K3AUA4
uniprot id: Q09EE8
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

6239:CELE T27C10.3
gene id: 6239:CELE_T27C10.3
uniprot id: Q9TZM2
names: Similarity
messages: Belongs to the Mo25 family.

6239:CELE T10H4.6
gene id: 6239:CELE_T10H4.6
uniprot id: O45774
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE D2023.1
gene id: 6239:CELE_D2023.1
uniprot id: G5EBI9
uniprot id: G5EGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F41B4.4
gene id: 6239:CELE_F41B4.4
uniprot id: Q8MXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

6239:CELE T24A6.8
gene id: 6239:CELE_T24A6.8
uniprot id: A0A131MB63
uniprot id: O61939
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K07C6.3
gene id: 6239:CELE_K07C6.3
uniprot id: O44651
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C50D2.7
gene id: 6239:CELE_C50D2.7
uniprot id: Q86S40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
messages: Monomer.
messages: Secreted

6239:CELE K07A12.4
gene id: 6239:CELE_K07A12.4
uniprot id: P90922
uniprot id: Q564V6
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE R05H5.4
gene id: 6239:CELE_R05H5.4
uniprot id: Q21764
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE R10E4.4
gene id: 6239:CELE_R10E4.4
uniprot id: Q21902
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).
messages: Nucleus
messages: cytosol

6239:CELE T10A3.1
gene id: 6239:CELE_T10A3.1
uniprot id: Q22366
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Observed in all larval stages.
messages: Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structural organization of synapses. May play a role in regulating entry into the dauer state (PubMed:30460068).
messages: Restricted to discrete puncta in synapse-rich regions of the nervous system including the nerve ring, the ventral nerve cord and the dorsal nerve cord. Localized expression was found in the head.
messages: Synapse

6239:CELE M01F1.4
gene id: 6239:CELE_M01F1.4
uniprot id: Q21453
uniprot id: Q5CZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

6239:CELE F57B9.10
gene id: 6239:CELE_F57B9.10
uniprot id: Q20938
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S9 family.
messages: By daf-16.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan.
messages: Embryonic lethal, larval arrest.

6239:CELE F46G10.3
gene id: 6239:CELE_F46G10.3
uniprot id: Q20481
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expression starts at the 100 cell stage during embryogenesis and is expressed throughout development until adulthood.
messages: Interacts with pyc-1, pcca-1 and mccc-1.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance (PubMed:23438705). Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2 (PubMed:28820880). Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked (PubMed:28820880).
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
messages: Ubiquitously expressed with high expression in the pharynx, body wall muscles and gonad. Strong expression in a subset of non-neuronal cells in the head.

6239:CELE T05A6.1
gene id: 6239:CELE_T05A6.1
uniprot id: Q22197
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CDI family.
messages: In embryos, expression is first seen in pharyngeal primordium and later in all differentiating cells. Post embryonic expression corresponds to developmental patterns of cell cycle progression in many tissues including sex myoblasts, distal tip cells, vulval cells, seam cells, neurons, intestine cells and hypodermal cells (PubMed:10587644, PubMed:9716524). During the development of distal tip cells (DTC), expressed asymmetrically between the daughters of the Z1.a and Z4.p cells; asymmetric expression is regulated by wrm-1, a component of the Wnt/MAPK pathway (PubMed:17476329).
messages: In embryos, expression is first seen in pharyngeal primordium and later in all differentiating cells. Post embryonic expression corresponds to developmental patterns of cell cycle progression in many tissues including sex myoblasts, distal tip cells, vulval cells, seam cells, neurons, intestine cells and hypodermal cells.
messages: Interacts with cyd-1 (Probable); the interaction is direct.
messages: Negative cell-cycle regulator that functions at the G1-to-S-phase transition (PubMed:10587644, PubMed:9716524). Required for suspension of the cell cycle in dauer larvae and starved L1 larvae (PubMed:10587644, PubMed:9716524). In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage (PubMed:10587644, PubMed:9716524, PubMed:15247923). Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation (PubMed:10587644). Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa (PubMed:17476329).
messages: Nucleus
messages: RNAi-mediated knockdown results in additional cell divisions in postembryonic intestinal cells characterized by a premature entry into S phase.

6239:CELE E04F6.11
gene id: 6239:CELE_E04F6.11
uniprot id: A0A0K3AR01
uniprot id: A0A0K3AR06
uniprot id: A0A0K3ARJ6
uniprot id: A0A0K3ATX5
uniprot id: A0A0K3ATY0
uniprot id: A0A0K3AUJ7
uniprot id: A0A0K3AWV4
uniprot id: Q9BMK9
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Cell membrane
messages: Expressed in excretory cell, 4 anterior epithelial cells of the intestine, hermaphrodite-specific neurons and enteric muscles (PubMed:11078724, PubMed:10567397). Expressed also in vulva and uterus (PubMed:10567397). Isoform a is expressed in oocytes (at protein level) (PubMed:11231150).
messages: Isoform a interacts (via RFLI motif) with gck-3 (via C-terminus).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phosphorylated by gck-3; phosphorylation at both Ser-742 and Ser-747 is required to inhibit channel activity (PubMed:19088383). Dephosphorylated by gsp-1/2 during cell swelling and oocyte meiotic maturation, which results in channel activation (PubMed:12163466).
messages: RNAi-mediated knockdown in oocytes results in inhibition of hyperpolarization-induced or swelling-induced current and in premature ovulatory contractions of gonadal sheath cells. Normal adaptive response to hypotonic swelling.
messages: The CBS domains, the R-helix linker (543-562) and the C-terminal domain (833-1001) regulate channel sensitivity to voltage, pH and extracellular chloride concentrations, probably by altering the outer pore structure (PubMed:16500974, PubMed:20581474). The region (738-751) between the CBS domains is essential for channel activation (PubMed:23083714).
messages: Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150). Sensitive to depolarizing conditioning voltages, requires stronger voltages for activation and activation is slower, is inhibited by low concentrations of chloride and is activated by low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974).
messages: Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150, PubMed:12163466, PubMed:15684092). Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974). Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells (PubMed:11231150, PubMed:24431435). When active, may prevent tubular formation of the excretory canals (PubMed:18049475). Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling (PubMed:11231150, PubMed:14565992). Inhibited by Zn(2+) and to a lesser extent by Cd(2+)(PubMed:11231150).

6239:CELE Y32F6A.2
gene id: 6239:CELE_Y32F6A.2
uniprot id: O45915
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F57B9.6
gene id: 6239:CELE_F57B9.6
uniprot id: P27639
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G (By similarity).

6239:CELE R74.5
gene id: 6239:CELE_R74.5
uniprot id: G5EEW7
uniprot id: M1ZJT7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W09D6.6
gene id: 6239:CELE_W09D6.6
uniprot id: G5EFD4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome
messages: Expressed in coelomocytes, as well as in head and tail neurons, and in the intestinal cells.
messages: Late endosome
messages: May play a pivotal role in the detoxification of heavy metals such as cadmium but do not depend exclusively on phytochelatins (PC) synthesis.
messages: RNAi-mediated knockdown causes hypersensitivity to Cd(2+) and exhibit Cd(2+)-elicited changes in cellular morphology. Even at the lowest Cd(2+) concentrations they arrest in the early larval stages and eventually die. The intestinal epithelial cells of hmt-1 RNAi worms upon exposure to toxic levels of Cd(2+) elaborate punctate refractive inclusions within the vicinity of the nucleus.
messages: Recycling endosome
messages: Vacuole membrane

6239:CELE F07C4.6
gene id: 6239:CELE_F07C4.6
uniprot id: P91208
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C18E9.11
gene id: 6239:CELE_C18E9.11
uniprot id: Q95NU5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen
messages: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
messages: Worms show defects in asymmetric divisions in early embryos. In particular, mutations specifically affect the reestablishment of asymmetric PAR protein domains in the P1 cell at the 2-cell stage.

6239:CELE Y48G10A.1
gene id: 6239:CELE_Y48G10A.1
uniprot id: G5EF86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

6239:CELE K11G12.1
gene id: 6239:CELE_K11G12.1
uniprot id: Q21432
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Defects lead to retarded growth.
messages: Expressed in the anterior part of the intestine, CEP neurons and to a lesser extent in hypodermis.
messages: Metalloprotease.
messages: Secreted

6239:CELE W02D9.2
gene id: 6239:CELE_W02D9.2
uniprot id: C6KRN3
uniprot id: D7SFP5
uniprot id: O02335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE B0495.4
gene id: 6239:CELE_B0495.4
uniprot id: Q8T5S1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Biphasic expression pattern with high expression in the L1 and L2 larval stages and gradual decrease through adult stages.
messages: Expressed uniformly in the intestinal epithelial cells.
messages: Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept-1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway.
messages: RNAi-mediated knockdown of the protein causes worms to become extremely lean and transparent. Slower progression through the larval stages, in particular the L1 and L2 stages. Increase in average life span, decreased brood size and loss of fat storage granules in the intestine leading to decreased opacity. Reduced rate of pharyngeal pumping, reduced size of proton pulses inside the cells, increased intracellular acidification, reduced uptake of fatty acids, and doubling of the defecation period.

6239:CELE F35C5.12
gene id: 6239:CELE_F35C5.12
uniprot id: G5EEA5
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F30B5.4
gene id: 6239:CELE_F30B5.4
uniprot id: Q19910
names: Similarity
messages: Belongs to the OKL38 family.

6239:CELE F57C2.6
gene id: 6239:CELE_F57C2.6
uniprot id: G5ECT7
uniprot id: H2FLK2
names: Similarity
messages: Belongs to the BORA family.

6239:CELE C41G6.5
gene id: 6239:CELE_C41G6.5
uniprot id: O17657
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T12A2.7
gene id: 6239:CELE_T12A2.7
uniprot id: Q22417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

6239:CELE C23G10.4
gene id: 6239:CELE_C23G10.4
uniprot id: Q18115
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

6239:CELE T22E5.2
gene id: 6239:CELE_T22E5.2
uniprot id: Q22682
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
messages: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport.

6239:CELE C09D4.1
gene id: 6239:CELE_C09D4.1
uniprot id: O01735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
messages: Membrane

6239:CELE F07B7.9
gene id: 6239:CELE_F07B7.9
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE ZK742.5
gene id: 6239:CELE_ZK742.5
uniprot id: Q23092
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE T01H3.3
gene id: 6239:CELE_T01H3.3
uniprot id: Q22089
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54E2.3
gene id: 6239:CELE_F54E2.3
uniprot id: V6CLP5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the pharyngeal, body wall, and anal depressor muscles (PubMed:16597697, PubMed:10669599, PubMed:16453162). Expression in these muscles is higher in hermaphrodites than in males (PubMed:10669599). Expressed in the vulva and the myoepithelial sheath of the proximal ovary (PubMed:16597697). Expressed in the proximal gonad of males (PubMed:10669599). Not expressed in the dense bodies of the obliquely striated body wall muscle (PubMed:16453162).
messages: First expressed in body wall muscle at the comma stage of embryonic development and co-localizes with actin at the early stage of myofibril assembly (PubMed:16597697). At the two-fold stage, it is expressed in body wall muscles and in the pharynx (PubMed:16597697). At the two-fold embryonic stage, assembles into continuously organized myofibrils (PubMed:31411810). Highly expressed in the body wall muscle and pharynx in three-fold stage embryos (PubMed:16597697, PubMed:31411810). In larvae, highly expressed in the pharyngeal, body wall, and anal depressor muscles (PubMed:10669599, PubMed:31411810).
messages: Interacts (via Ig-like domains) with F-actin.
messages: Lethal during the larval stage of development with body elongation defects (PubMed:31411810). L1 stage larvae have severely disorganized actin filaments in the striated body wall muscle whereby actin filaments and tropomyosin assemble into thicker and fewer disorganized bundles (PubMed:31411810). Furthermore, the sarcomeric organization of actin and myo-3 is disrupted in body wall muscle cells (PubMed:31411810). RNAi-mediated knockdown reduces the brood size and results in a defective body wall muscle contractility (PubMed:16597697). RNAi-mediated knockdown results in small round actin aggregates or unusual accumulations of actin in body wall muscle in 23% of animals (PubMed:16597697). Larger actin aggregates form more frequently at the cell periphery in 94% of animals in response to tetramisole, an agonist of acetylcholine receptors (PubMed:16597697). RNAi-mediated knockdown enhances the disorganization of the actin filaments and results in larger actin aggregates in an atn-1 ok84 mutant background (PubMed:16597697).
messages: Positively regulates actin filament organization and provides mechanical stability to the myofibrils during body wall muscle contraction (PubMed:16597697). Required for the organization of sarcomeric actin filaments and myosin protein myo-3 in striated body wall muscle cells (PubMed:31411810). Not required for assembly of dense bodies, which are a type of integrin-based adhesion structure that link the plasma membrane to thin filaments of myofibrils, in body wall muscle (PubMed:31411810). Not required for the atn-1 protein to localize to the dense bodies (PubMed:31411810).
messages: cytoskeleton
messages: sarcomere

6239:CELE F35H10.6
gene id: 6239:CELE_F35H10.6
uniprot id: Q20070
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE F58D5.4
gene id: 6239:CELE_F58D5.4
uniprot id: G5EDA5
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Interacts with ndk-1.
messages: Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf (PubMed:23900546, PubMed:11882296). In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation (PubMed:11882296, PubMed:26510792). Plays a role in meiotic recombination events (PubMed:26510792). Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells (PubMed:11882296).
messages: RNAi-mediated knockdown causes sterility characterized by a lack of oocytes. In a ksr-1 n2526 mutant background, causes larval lethality.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE ZK829.5
gene id: 6239:CELE_ZK829.5
uniprot id: Q23622
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC13.1
gene id: 6239:CELE_ZC13.1
uniprot id: Q7JNM2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C09B9.85
gene id: 6239:CELE_C09B9.85
uniprot id: J7RNL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C16A3.7
gene id: 6239:CELE_C16A3.7
uniprot id: Q18034
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: May play a role in transcription regulation.
messages: Nucleus

6239:CELE T26E3.2
gene id: 6239:CELE_T26E3.2
uniprot id: O45830
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

6239:CELE Y43F4B.10
gene id: 6239:CELE_Y43F4B.10
uniprot id: Q8MPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

6239:CELE F14F3.1
gene id: 6239:CELE_F14F3.1
uniprot id: G5EDS1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Cytoplasm
messages: Expressed in BAG neurons.
messages: Expressed in RS.a and RB.p in late larval stage L3, in ray 6 and ray 8 cells in late L4, in neurons descended from P11.a in the preanal ganglion in L4 males and head hypodermis and a pair of bilaterally symmetrical neurons in the head anterior of the nerve ring in L4 males (at protein level) (PubMed:7659160, PubMed:9858725). Also expressed in seminal vesicle cells in late L4 males (at protein level) (PubMed:9858725).
messages: Expressed in the anterior part of comma-stage embryos (PubMed:11476572, PubMed:18313275). In larvae, expressed strongly in almost all anterior hypodermal cells and weakly in many head neurons (PubMed:7659159, PubMed:18313275). Expressed in the gonadal DTCs during ventral migration in hermaphrodite L4 larvae (PubMed:17606640, PubMed:18313275). Expressed in the male hindgut, in B.a and Y.p sensory organ precursors, from the early L2 and until the mid L3 larval stages (PubMed:18313275). Expression diminishes in the B.a lineage during late L4 tail morphogenesis, and is absent in adults (PubMed:18313275). Expression in the Y.p lineage diminishes in the mid L3 stage (PubMed:18313275). Male hindgut expression is restricted to specific lineages in a lin-48 and egl-38 dependent manner (PubMed:18313275).
messages: Expressed widely in head epidermal cells and neurons, including BAG sensory neurons.
messages: First expressed at about 5 hours of embryogenesis in 20-30 anterior dorsal cells, corresponding to the hypodermal cells of the head, and lateral sets of about 10 cells, of which some are probably future head neurons (PubMed:7659159). By the 1.5-fold stage, expressed in hypodermal and neuronal cells in a broad region of the head (PubMed:7659159).
messages: Not expressed in BAG neurons.
messages: Nucleus
messages: Probable cloning artifact.
messages: RNAi-mediated knockdown causes defects in gonadal distal tip cell migration (PubMed:17606640). RNAi-mediated knockdown reduces expression of the integrin alpha pat-2 in gonadal DTCs in about 70% of individuals and in 90% on a vab-3 mutant background (PubMed:17606640). RNAi-mediated knockdown increases expression of the integrin alpha ina-1 in gonadal DTCs in hermaphrodites (PubMed:17606640). RNAi-mediated knockdown induces generation of additional dopaminergic neurons (PubMed:21079745). BAG sensory neuron-specific RNAi-mediated knockdown reduces expression of receptor-type guanylyl cyclase gcy-9 (PubMed:30890567).
messages: Transcription factor involved in head epidermal morphogenesis and required for normal cell fate in anterior lateral epidermal blast (seam) cells (PubMed:7659159, PubMed:15579687). Required for the generation or differentiation of neurons of the anterior ganglion, probably acting upstream of unc-86 (PubMed:8647436). Represses BAG sensory neuron fate in non-BAG cells, probably through cooperation with the phosphatase eya-1 and transcription factor ceh-32 (PubMed:30890567). May be involved in regulating the generation of dopaminergic neurons (PubMed:21079745). May cooperate with hlh-17 to preferentially regulate expression of hlh-17 in ventral CEPsh glia (PubMed:18508862).
messages: Transcription factor that acts within the male-specific genital sensilla (simple sense organs) known as rays to determine their identity (PubMed:7659160, PubMed:1782863, PubMed:15579687). Promotes BAG sensory neuron fate in a cell-autonomous manner (PubMed:30890567). Required for function of chemosensory BAG neurons (PubMed:30890567).
messages: Transcription factor that binds a motif with the core sequence 5'-GCGTA-3' in the promoter of various genes (PubMed:11476572, PubMed:30890567). During development, required for cell fate specification probably by promoting or repressing expression of genes involved in specific cell fate (PubMed:30890567, PubMed:11476572, PubMed:7649393). Involved in head epidermal morphogenesis (PubMed:7659159). Involved in gonadal distal tip cell (DTC) migration, during which modulates expression of the integrin alpha genes, pat-2 and ina-1 (PubMed:10388818, PubMed:17606640, PubMed:15579687). Regulates ventral and dorsal cephalic sheath (CEPsh) glia differentiation and expression of transcription factor hlh-17 in CEPsh glia (PubMed:18508862). Plays a role in establishing unequal cytokinesis and cell fate specification in male-specific postembryonic blast cell B (PubMed:7649393). May cooperate with the phosphatase eya-1 and transcription factor ceh-32 to regulate the transcription factor ets-5 (PubMed:30890567).

6239:CELE T05E11.5
gene id: 6239:CELE_T05E11.5
uniprot id: P49049
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1 (PubMed:15469912). Involved in embryonic and larval development (PubMed:15469912, PubMed:29137240).
messages: Belongs to the peptidase A22B family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: RNAi-mediated knockdown results in late stage embryonic and larval lethality, slow growth and pharyngeal pumping, uncoordinated movement, reduced brood size, middle body constriction, and muscle detachment (PubMed:15469912, PubMed:29137240). RNAi-mediated knockdown in L1 larvae causes incomplete cuticle shedding during molting (PubMed:15469912).
messages: The PAL motif is required for normal active site conformation.

6239:CELE E02H4.4
gene id: 6239:CELE_E02H4.4
uniprot id: Q19040
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C37H5.9
gene id: 6239:CELE_C37H5.9
uniprot id: P91137
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Defects lead to embryonic lethality in 6% of population.
messages: Expressed in hypodermis, uterus and spermatheca.
messages: Metalloprotease.
messages: Secreted

6239:CELE T28F2.4
gene id: 6239:CELE_T28F2.4
uniprot id: O01658
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Attenuated response to heat shock stress and reduced survival after heat shock and oxidative stress.
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress.

6239:CELE C14C6.6
gene id: 6239:CELE_C14C6.6
uniprot id: O44670
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C09E9.1
gene id: 6239:CELE_C09E9.1
uniprot id: Q93196
names: Similarity
messages: Belongs to the TUSC2 family.

6239:CELE C53B4.3
gene id: 6239:CELE_C53B4.3
uniprot id: Q18797
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T04H1.8
gene id: 6239:CELE_T04H1.8
uniprot id: Q22181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C09H6.3
gene id: 6239:CELE_C09H6.3
uniprot id: O17581
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC4/mau-2 family.
messages: Chromosomal, neuroanatomical, guidance and egg-laying defects. Altering the activity of both the dorsal repellent slt-1 and mau-2 leads to the abnormal dorsal projection of the AVM axon. Migrating cells and axons are mispositioned along both the antero-posterior and dorsoventral body axes.
messages: Cytoplasm
messages: May heterodimerize with scc-2/SCC2 to form the cohesin loading complex.
messages: Plays an important role in the loading of the cohesin complex on to DNA (By similarity). Forms a heterodimeric complex (also known as cohesin loading complex) with scc-2/SCC2 which mediates the loading of the cohesin complex onto chromatin (By similarity). Required for normal development until the fourth larval stage. Functions cell autonomously to guide migrations during the development of the nervous system. Participates in the guidance of mechanosensory neuron AVM by a slt-1-independent mechanism. Regulates chromosome segregation in early embryos.
messages: Ubiquitously expressed in embryos by late gastrulation. Becomes predominantly expressed in the nervous system as morphogenesis progresses.
messages: nucleoplasm

6239:CELE C06A6.3
gene id: 6239:CELE_C06A6.3
uniprot id: Q17687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

6239:CELE C49G7.11
gene id: 6239:CELE_C49G7.11
uniprot id: O16228
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C56 family. DJ-1 subfamily.
messages: Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration.
messages: Cytoplasm
messages: Expressed in various tissues, including pharyngeal muscles, pharynx-intestinal valve, ventral nerve cord, spermatheca, rectal gland, inner labial (IL) cells of head neurons, phasmid (PHA/PHB) neurons in tail and supporting sheath/socket cells, as well as in head mesodermal cells (HMC), excretory canals and coelomocytes.
messages: Induced by DAF-16 during starvation as well as in the dauer stage.

6239:CELE F21D5.3
gene id: 6239:CELE_F21D5.3
uniprot id: Q19687
names: Similarity
messages: Belongs to the multicopper oxidase family.

6239:CELE D2085.3
gene id: 6239:CELE_D2085.3
uniprot id: Q18994
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

6239:CELE F58A4.10
gene id: 6239:CELE_F58A4.10
uniprot id: P34477
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.

6239:CELE M01F1.6
gene id: 6239:CELE_M01F1.6
uniprot id: Q21454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

6239:CELE F42H11.2
gene id: 6239:CELE_F42H11.2
uniprot id: G5EGA3
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm
messages: Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation (PubMed:22383942). Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation (PubMed:22383942). Resolves chromatin bridges in late mitosis that result from incomplete DNA replication, defective chromosome condensation or unresolved recombination intermediates (PubMed:29463814). Together with brc-1, contributes to genome integrity by resolving mitotic chromatin bridges that result from incomplete processing of DNA breaks (PubMed:29463814). In parallel to the slx-1/mus-81 pathway, acts in processing early recombination intermediates in meiotic prophase I to prevent illegitimate recombination (PubMed:29879106). Also involved in processing remaining, erroneous recombination intermediates that persist into the second meiotic division (PubMed:29879106).
messages: Expressed in embryos.
messages: Inhibited by EDTA.
messages: Midbody
messages: Nucleus
messages: Phosphorylated. Phosphorylated during telophase when localized at the midbody.
messages: spindle

6239:CELE M6.3
gene id: 6239:CELE_M6.3
uniprot id: Q21578
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Earliest expression in 4-8 cells of the pharyngeal primordium at around 280-300 min of embryonic development (PubMed:15282157). Expressed just before the comma stage (approximately 350 min) in two groups of pharyngeal primordium cells, persisting until the 3-fold stage (PubMed:15282157). At the 3-fold stage, expressed in several cells of the tail; expression continues in larvae and adults in several cells of the head, including at least two amphid neurons, intestinal cells, three rectal gland cells and 1-2 other unidentified rectal cells (PubMed:15282157).
messages: Nucleus
messages: Transcriptional repressor (By similarity). Involved in pharyngeal development and required for the formation of the pharyngeal isthmus (PubMed:15282157, PubMed:16806153). Plays a role in modulating cytoskeleton in the muscle cells of the isthmus (PubMed:16806153). Regulates expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:16806153). May regulate its own expression (PubMed:15282157).

6239:CELE F07C4.8
gene id: 6239:CELE_F07C4.8
uniprot id: P91211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F52C12.1
gene id: 6239:CELE_F52C12.1
uniprot id: Q9TXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
messages: Nucleus

6239:CELE ZC373.5
gene id: 6239:CELE_ZC373.5
uniprot id: Q23261
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

6239:CELE ZK377.1
gene id: 6239:CELE_ZK377.1
uniprot id: P91573
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Expressed in 4 to 7 sheath and socket cells of the anterior sensilla.
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE Y17D7B.1
gene id: 6239:CELE_Y17D7B.1
uniprot id: O45910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y39B6A.6
gene id: 6239:CELE_Y39B6A.6
uniprot id: Q9NET3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y39C12A.6
gene id: 6239:CELE_Y39C12A.6
uniprot id: Q9U2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y66H1A.4
gene id: 6239:CELE_Y66H1A.4
uniprot id: Q9TYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE B0228.6
gene id: 6239:CELE_B0228.6
uniprot id: Q09223
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C03C11.2
gene id: 6239:CELE_C03C11.2
uniprot id: G5EDX7
names: Similarity
messages: Belongs to the BTG family.

6239:CELE F53B6.4
gene id: 6239:CELE_F53B6.4
uniprot id: Q9XVN1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE BE0003N10.1
gene id: 6239:CELE_BE0003N10.1
uniprot id: Q965N3
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

6239:CELE B0024.2
gene id: 6239:CELE_B0024.2
uniprot id: Q17418
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F21F3.5
gene id: 6239:CELE_F21F3.5
uniprot id: Q23022
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:9221782, PubMed:15990870, PubMed:20027209). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209). Involved in nAChR sensitivity to nicotine (PubMed:9221782, PubMed:15990870).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Component of nicotinic acetylcholine receptor (PubMed:15990870, PubMed:20027209). In muscles, composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8 (PubMed:15990870). In cholinergic motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3 alpha subunits unc-38, unc-63 and acr-12 (PubMed:20027209).
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis.

6239:CELE K12D9.7
gene id: 6239:CELE_K12D9.7
uniprot id: P91382
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F31E3.1
gene id: 6239:CELE_F31E3.1
uniprot id: P41779
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TALE/PBX homeobox family.
messages: Expressed in QR and QL neuroblasts, P and V cells and all their respective descendents, M cells, BDU interneurons, ALM and HSM neurons, body wall muscles, I4, all ventral cord neurons and in a few unidentified neurons in the head behind the posterior bulb of the pharynx during the L1 stage of larval development (PubMed:15750187). Expressed in V cell descendents from the larval stage of development to adulthood (PubMed:15750187). Expressed in the midbody dopaminergic PDE neurons throughout life (PubMed:23788625).
messages: Expressed in head dopaminergic neurons.
messages: Interacts with Meis protein psa-3 (PubMed:16824957). Interacts with homeobox protein nob-1 (PubMed:16824957).
messages: Nucleus
messages: RNAi-mediated knockdown results in egg laying defects, abnormal migration of QR neuroblast lineage cells and vulval protrusions due to ectopic induction and defective morphogenesis of vulval precursors cells (PubMed:15750187). RNAi-mediated knockdown results in the absence of the transcription factor, mls-2, in the M lineage (PubMed:18316179).
messages: Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)-3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage) (PubMed:21307099). Required for the M lineage-specific expression of the transcription factor, mls-2 (PubMed:18316179). Required for asymmetric division of the T hypodermal cell, probably acting via the regulation of asymmetric expression of Meis protein psa-3 in concert with homeobox protein nob-1 and the Wnt-MAPK pathway (PubMed:16824957). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons (PubMed:15750187). Also required for normal vulval formation (PubMed:15750187). Plays a role in regulating gene expression in dopaminergic neurons, acting in midbody PDE neurons, and acting redundantly with ceh-40 in head neurons (PubMed:23788625). May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-43 and ceh-40 (PubMed:23788625).

6239:CELE T02E1.5
gene id: 6239:CELE_T02E1.5
uniprot id: A5JYX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expressed in the intestine and vulva.
messages: Lipid droplet
messages: May play a role in lipid droplet formation. May modulate triglyceride levels.
messages: Not expressed in embryos.
messages: Viable, but intestinal cells contain lipid droplets that are reduced in size and that contained a reduced amount of triglycerides as compared to wild-type.

6239:CELE Y37E3.11
gene id: 6239:CELE_Y37E3.11
uniprot id: A9D2X7
uniprot id: Q9BKU2
uniprot id: X5LPW7
uniprot id: X5LPX5
uniprot id: X5LV72
uniprot id: X5LX84
uniprot id: X5M5S8
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE T13F2.5
gene id: 6239:CELE_T13F2.5
uniprot id: Q94048
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F20D12.4
gene id: 6239:CELE_F20D12.4
uniprot id: Q19642
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZW10 family.
messages: Component of the RZZ complex composed of rod-1, czw-1 and zwl-1.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:9298984). Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores (PubMed:18936247). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18936247). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790, PubMed:18936247). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:9298984).
messages: RNAi-mediated knockdown largely results in sterility (PubMed:9298984, PubMed:18765790, PubMed:19109417). RNAi-mediated knockdown also results in a high incidence of embryonic lethality in the embryos produced and defects in mitosis which include the formation of chromatin bridges in between sister chromatids during anaphase (PubMed:9298984). In addition, there is reduced localization of the spindly-like protein spdl-1 to kinetochores, but not to microtubules (PubMed:18936247).
messages: kinetochore
messages: spindle

6239:CELE R07C3.4
gene id: 6239:CELE_R07C3.4
uniprot id: O16775
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F18A12.1
gene id: 6239:CELE_F18A12.1
uniprot id: O16795
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE F42F12.4
gene id: 6239:CELE_F42F12.4
uniprot id: Q20340
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

6239:CELE ZK550.4
gene id: 6239:CELE_ZK550.4
uniprot id: G5EG49
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.

6239:CELE F57C9.3
gene id: 6239:CELE_F57C9.3
uniprot id: O01822
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S6 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.
messages: Cytoplasm
messages: Endosome
messages: Expressed in developing embryos in intestinal cells (at protein level).
messages: Homodimer (isoform 1). Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1 (By similarity). Isoform 1 interacts with blos-1 and blos-4.

6239:CELE C50C3.7
gene id: 6239:CELE_C50C3.7
uniprot id: P34370
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Cytoplasm
messages: Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2.
messages: Expressed in tail, cilia, dendrites, axon and male head.
messages: Reduced mating efficiency. Defective sperm. Abnormal distribution of pkd-2.

6239:CELE F59A3.1
gene id: 6239:CELE_F59A3.1
uniprot id: P91359
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE M106.7
gene id: 6239:CELE_M106.7
uniprot id: Q0G841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

6239:CELE F22F7.7
gene id: 6239:CELE_F22F7.7
uniprot id: A0A0K3ARZ2
uniprot id: A0A0K3AVG7
uniprot id: Q9GZE8
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

6239:CELE W03G9.1
gene id: 6239:CELE_W03G9.1
uniprot id: O44752
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F09G2.4
gene id: 6239:CELE_F09G2.4
uniprot id: O17403
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: CPSF is a heterotetramer composed of four distinct subunits 160, 100, 70 and 30 kDa.
messages: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
messages: Nucleus

6239:CELE F47E1.2
gene id: 6239:CELE_F47E1.2
uniprot id: Q20538
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C06B8.8
gene id: 6239:CELE_C06B8.8
uniprot id: O17570
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

6239:CELE T07D4.3
gene id: 6239:CELE_T07D4.3
uniprot id: Q22307
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Component of the coding region determinant (CRD)-mediated complex. Identified in mRNP granule complexes containing untranslated mRNAs. Associates with the RISC complex. Associates with the SMN complex. Associates with polysomes.
messages: Cytoplasm
messages: DRBM domains cooperate for the binding to nucleic acid but not for unwinding helicase activity. The helicase-associated domain-2 (HA2) region is essential for the duplex RNA unwinding helicase activity. The minimal transactivation region (MTAD) mediates interaction with the RNA polymerase II holoenzyme and stimulates transcriptional activation. The oligonucleotide- or oligosaccharide-binding (OB-fold) and the repeated arginine and glycine-glycine (RGG) regions are dispensable for both RNA-binding and unwinding helicase activities. The RGG region contains both nuclear localization signal (NLS) and nuclear export signal (NES) and is necessary and sufficient for nucleocytoplasmic shuttling in a RNA-independent manner.
messages: Expressed in the pachytene region of the gonad and in the oocytes.
messages: Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replication at origins of replication and cell cycle progression (By similarity). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors (PubMed:15817227). Plays several roles in post-transcriptional regulation of gene expression. Promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Also plays a role in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (By similarity).
messages: Nucleus
messages: centrosome
messages: nucleolus
messages: nucleoplasm

6239:CELE F59E10.2
gene id: 6239:CELE_F59E10.2
uniprot id: P52012
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the early larval stages with lower levels at later larval and adult stages.
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Exclusively in the larval body wall striated muscle cells.
messages: Interacts with mep-1.
messages: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.
messages: Nucleus

6239:CELE T03D8.5
gene id: 6239:CELE_T03D8.5
uniprot id: Q9XTY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expression in ASER neuron begins at an early larval stage and is maintained in the adult.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron (PubMed:19523832, PubMed:20837997). May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations (PubMed:19523832).
messages: The extracellular and guanylate cyclase domains are essential for chemosensory responses.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE C09G12.8
gene id: 6239:CELE_C09G12.8
uniprot id: Q03206
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Colocalizes with pak-1 to hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis.
messages: In the second generation, there is defective mitotic spindle orientation in the EMS and ABar blastomeres which results in disrupted left-right asymmetry and failure to undergo morphogenesis (PubMed:20126385). Due to defective apoptotic cell clearance, embryos accumulate apoptotic cell corpses (PubMed:20126385). Distal tip cell migratory defects (PubMed:26292279). Double knockout with unc-5 RNAi suppresses the distal tip cell migratory defect in the ced-10 single mutant (PubMed:26292279).
messages: Interacts (GTP-bound form) with pak-1 (PubMed:8824291). May interact (GTP-bound form) with mig-10 (via Ras-associating and PH domains) (PubMed:18499456). Interacts (GTP-bound form) with chdp-1 (via CH domain); the interaction facilitates the localization of ced-10 to the cell cortex (PubMed:27415421).
messages: Most abundant at embryonic stage, its expression decreases dramatically during development.
messages: Required in engulfing to control the phagocytosis of apoptotic cell corpses (PubMed:10707082, PubMed:20126385). Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:20126385). Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces (PubMed:10707082). Plays a redundant role with mig-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. May regulate these 2 processes by activating pak-1 and/or max-2 (PubMed:17050621). Plays a role, probably via mig-10, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. Regulates mig-10 asymmetric distribution in HSN neurons (PubMed:18499456). During the dorso-ventral axonal guidance and outgrowth of VD neurons, required together with mig-2 to inhibit growth cone filopodial protrusion mediated by netrin guidance cue unc-6 and its receptors unc-5 and unc-40 (PubMed:25371370, PubMed:30045855). Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and, together with mig-2, by restricting plus-end microtubule accumulation in the growth cone (PubMed:30045855). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382). During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419). Furthermore, plays a role in distal tip cell polarity and migration by negatively regulating the unc-6/Netrin receptor unc-5 (PubMed:26292279). May be involved in signal transduction during cell migration (PubMed:10…

6239:CELE F32D8.5
gene id: 6239:CELE_F32D8.5
uniprot id: Q19966
uniprot id: Q9U3H0
names: Similarity
messages: Belongs to the TMEM70 family.

6239:CELE K07A12.1
gene id: 6239:CELE_K07A12.1
uniprot id: P90919
names: Similarity
messages: Belongs to the TCF25 family.

6239:CELE ZK418.9
gene id: 6239:CELE_ZK418.9
uniprot id: Q23487
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08D10.12
gene id: 6239:CELE_K08D10.12
uniprot id: Q8MQ07
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

6239:CELE K07F5.7
gene id: 6239:CELE_K07F5.7
uniprot id: Q21290
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C49G7.8
gene id: 6239:CELE_C49G7.8
uniprot id: O16220
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F18A12.6
gene id: 6239:CELE_F18A12.6
uniprot id: O16790
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE ZK20.4
gene id: 6239:CELE_ZK20.4
uniprot id: Q23450
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

6239:CELE M04C7.1
gene id: 6239:CELE_M04C7.1
uniprot id: P91907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE ZK1127.2
gene id: 6239:CELE_ZK1127.2
uniprot id: Q23404
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE K03A1.5
gene id: 6239:CELE_K03A1.5
uniprot id: Q21166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Cytoplasm
messages: Nucleus
messages: Present in most cells of the organism.

6239:CELE Y54E2A.3
gene id: 6239:CELE_Y54E2A.3
uniprot id: G5ECG0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TACC family.
messages: Cytoplasm
messages: Expressed in touch neurons.
messages: Interacts with zyg-9 to form a heterodimer (PubMed:12956950, PubMed:12956951, PubMed:12956952). Interacts with zyg-8 to form a heterodimer (PubMed:17666432). Interacts with efa-6 (via N-terminus) (PubMed:26339988).
messages: Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length (PubMed:12956950, PubMed:12956951, PubMed:16054029). Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis (PubMed:12956950, PubMed:12956951). In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle (PubMed:12956950, PubMed:12956952). Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly (PubMed:12956952). At anaphase, the complex is required for mitotic spindle positioning in one-cell stage embryos (PubMed:17666432). The complex acts in a partially redundant manner with the tac-1/zyg-8 complex to regulate microtubule assembly and processes during interphase, mitosis and meiosis in embryos (PubMed:17666432). Plays a role in injury-induced axonal regrowth, regeneration and microtubule stability in PLM neurons and this may be downstream of efa-6 (PubMed:26339988).
messages: Maternal-effect embryonic lethal (PubMed:23155404). RNAi-mediated knockdown results in a meiotic defect in 30% of early embryos and defective microtubule related processes during the first cell cycle in early embryogenesis (PubMed:12956950, PubMed:12956951, PubMed:12956952). In one-cell embryos, the maternal pronuclei fail to migrate and the breakdown of the pronuclear envelope is delayed (PubMed:12956950, PubMed:12956951, PubMed:12956952). The sperm pronuclear complex also exhibits a migratory defect whereby it does not move to the center of the embryo or rotate on the anterior-posterior axis leading to the assembly of a misaligned spindle at the posterior of the embryo and ingression of the cleavage furrow from the posterior cortex (PubMed:12956950, PubMed:12956951, PubMed:12956952, PubMed:17666432). Reduced microtubule growth rate in embryos (PubMed:16054029). Defective microtubule elongation in one-cell embryos resulting in short microtubules that extend from the centrosome, but do not extend to the cortex, and mitotic spindles that are 20% shorter than in wild-type one-cell embryos (PubMed:12956950, PubMed:12956951). Specifically, one-cell embryos have shorter astral and mitotic spindle microtubules (PubMed:12956952). Reduced stability of the zyg-9/tac-1 complex with reduced accumulation of zyg-9 at the centrosomes (PubMed:12956950).
messages: Perikaryon
messages: axon
messages: centrosome
messages: kinetochore
messages: spindle pole

6239:CELE T10E9.9
gene id: 6239:CELE_T10E9.9
uniprot id: A0A0K3AQR2
uniprot id: O01607
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE C18B12.6
gene id: 6239:CELE_C18B12.6
uniprot id: G5EEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane

6239:CELE F57G9.4
gene id: 6239:CELE_F57G9.4
uniprot id: O62269
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T15H9.3
gene id: 6239:CELE_T15H9.3
uniprot id: Q10007
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the gland cells of the pharynx and weakly in the pharyngeal neuron.
messages: Nucleus
messages: Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding (PubMed:18927627). Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes (PubMed:18927627). Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source (PubMed:18927627). Exhibits pharyngeal gland-specific positive autoregulation activity (PubMed:17049341).

6239:CELE T15B7.4
gene id: 6239:CELE_T15B7.4
uniprot id: O17036
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F47D12.4
gene id: 6239:CELE_F47D12.4
uniprot id: Q09390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Nucleus

6239:CELE F09G8.3
gene id: 6239:CELE_F09G8.3
uniprot id: P34388
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE R07H5.8
gene id: 6239:CELE_R07H5.8
uniprot id: Q93934
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

6239:CELE Y19D10A.11
gene id: 6239:CELE_Y19D10A.11
uniprot id: A0A0M7RDV0
uniprot id: A0A0M9JJ95
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F36H9.4
gene id: 6239:CELE_F36H9.4
uniprot id: A0A0K3AXT1
uniprot id: O16620
names: Subcellular Location Annotation
messages: Secreted

6239:CELE ZK112.7
gene id: 6239:CELE_ZK112.7
uniprot id: P34616
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 2 percent of mutants have a delay in anchor cell invasion. In 7 percent of zmp-1 and cdh-3 double mutants and in 25 percent of cdh-3, him-4 and zmp-1 triple mutants, anchor cell invasion is delayed.
messages: Basolateral cell membrane
messages: Cell adhesion protein involved in the control of epithelial morphogenesis (PubMed:9012534). Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development (PubMed:15960981).
messages: Cell junction
messages: Cell membrane
messages: Expressed in the anchor cell.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

6239:CELE F56H1.6
gene id: 6239:CELE_F56H1.6
uniprot id: Q4W4Z2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Expressed in pharynx, muscles and intestine.
messages: Mitochondrion
messages: Plays a role in oxygen metabolism in the mitochondria by regulating the levels of reactive oxygen species (ROS) thereby conferring resistance to oxidative stress (PubMed:7152245, PubMed:8350650, PubMed:8169328, PubMed:21895890). Involved in resistance to P.aeruginosa PA14 infection (PubMed:9989496). Regulates lifespan (PubMed:8169328).
messages: Under hyperoxic conditions or low temperature (16 degrees Celsius), lifespan, body size and fertility are severely reduced and sexual maturity and egg hatching are delayed (PubMed:8350650, PubMed:8169328). Slight increase in the number of apoptotic cells at the embryonic comma stage (PubMed:21895890). Also shows strong susceptibility to UV irradiation and paraquat treatment. Does not show increased sensitivity to X-ray radiation (PubMed:7152245, PubMed:8350650). Increased sensitivity to P.aeruginosa PA14-mediated killing (PubMed:9989496). Body wall muscle mitochondria appear enlarged and abnormal with less developed cristae in hypoxic or hyperoxic conditions (PubMed:21895890).

6239:CELE Y59A8B.21
gene id: 6239:CELE_Y59A8B.21
uniprot id: Q9GRY3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K07F5.4
gene id: 6239:CELE_K07F5.4
uniprot id: D6R8W4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE R01H10.8
gene id: 6239:CELE_R01H10.8
uniprot id: G5EEW9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNKSR family.
messages: Cytoplasm
messages: Membrane
messages: No apparent phenotype. Double mutant cnk-1 and lin-45 and double mutant cnk-1 and ksr-1 show high lethality in the first larval stage, filling with fluid and with a rod-like appearance due to loss of the excretory duct. Double mutant cnk-1 and lin-45 also shows P12 to P11 cell fate transformations.
messages: Non-essential component of the Ras signaling pathway.

6239:CELE K03B4.3
gene id: 6239:CELE_K03B4.3
uniprot id: Q21172
uniprot id: Q95ZS0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF10 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed from the 4-cell stage through late gastrulation (at protein level) (PubMed:11566890). May be maternally expressed (PubMed:11566890).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890). Abolishes expression of taf-9, perhaps as a result of altered protein stability (PubMed:11566890). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-10 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.
messages: Throughout PMID:11566890, the gene name taf-11 is used instead of taf-10, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE C42C1.2
gene id: 6239:CELE_C42C1.2
uniprot id: A3QMB1
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE W03F9.4
gene id: 6239:CELE_W03F9.4
uniprot id: A0A0K3ASC9
uniprot id: O16992
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE C25F6.2
gene id: 6239:CELE_C25F6.2
uniprot id: G5ECY0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the MAGUK family.
messages: Cytoplasm
messages: Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019, PubMed:18411252).
messages: Expressed in the apical junctions in the hypodermis.
messages: Homooligomerizes; requires L27 domain (PubMed:18411252). Interacts (via L27 domain) with ajm-1; the interaction regulates ajm-1 apical junction location (PubMed:11715019, PubMed:18411252).
messages: Lateral cell membrane
messages: Membrane
messages: Mutant embryos have elongation arrested immediately before or at the 2-fold stage. They display a large vacuole in the posterior region.
messages: PDZ domains are required for localization at the adherens junctions. SH3 domain is necessary for let-413 dependent lateral distribution. L27 domain is responsible for homooligomerization and interaction with ajm-1.
messages: adherens junction

6239:CELE Y41E3.4
gene id: 6239:CELE_Y41E3.4
uniprot id: D3YT95
uniprot id: D3YT96
uniprot id: O62431
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE C29E4.2
gene id: 6239:CELE_C29E4.2
uniprot id: P34341
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Chromosome
messages: Component of the condensin II complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits, capg-2, kle-2 and hcp-6 that probably regulate the complex (PubMed:19119011). Within the complex, interacts with mix-1, smc-4, capg-2 and hcp-6 (PubMed:19119011, PubMed:28301465).
messages: Nucleus
messages: RNAi-mediated knockdown leads to disorganized chromosome morphology, causes DNA bridges in mitosis and leads to chromosome segregation defects in mitosis and meiosis.
messages: Regulatory subunit of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and in chromosome segregation in mitosis and in meiosis.
messages: centromere

6239:CELE C02C2.5
gene id: 6239:CELE_C02C2.5
uniprot id: P34273
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nitroreductase family.
messages: Expressed in body-wall, anal depressor and vulval muscles.
messages: May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.
messages: Membrane
messages: No visible phenotype. Fully suppresses the rubber band uncoordinated phenotype in gain of function (gf) mutants of sup-10 but only slightly in gf mutants of sup-9 and unc-93.

6239:CELE K07F5.9
gene id: 6239:CELE_K07F5.9
uniprot id: Q21289
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE C02F5.1
gene id: 6239:CELE_C02F5.1
uniprot id: P34278
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed on chromosomes from early prophase until late anaphase.
messages: Interacts with hcp-3 and hcp-4 to form a complex (PubMed:14522947). Interacts with hcp-4, him-10, kbp-3, kbp-4, kbp-5, knl-3, and ndc-80 (PubMed:15371340). Interacts with kbp-1, kbp-2 and mis-12; which make up the MIS12 complex (PubMed:17129783).
messages: Perturbed spindle-kinetochore interactions, segregation defects and premature spindle elongation (PubMed:14522947, PubMed:15767665, PubMed:18070910). RNAi-mediated knockdown results in reduced localization of the spindly-like protein spdl-1 and the RZZ complex component zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Does not affect spdl-1 localization to microtubules (PubMed:18936247).
messages: Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division (PubMed:14522947, PubMed:15371340, PubMed:17129783, PubMed:18070910). Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy (PubMed:15767665, PubMed:16273096). Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (PubMed:19109417, PubMed:20729837, PubMed:24567362).
messages: The N-terminus contains a number of repeats which contribute additively to bub-1 recruitment to unattached kinetochores. The repeats are not required for localization to kinetochores.
messages: cell cortex
messages: kinetochore

6239:CELE F36F12.2
gene id: 6239:CELE_F36F12.2
uniprot id: O76399
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y43F4B.5
gene id: 6239:CELE_Y43F4B.5
uniprot id: O45934
uniprot id: Q86DA0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

6239:CELE E02H1.7
gene id: 6239:CELE_E02H1.7
uniprot id: Q09528
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F21F8.1
gene id: 6239:CELE_F21F8.1
uniprot id: O01538
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE Y51F10.5
gene id: 6239:CELE_Y51F10.5
uniprot id: Q8WTK2
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6239:CELE C15A11.6
gene id: 6239:CELE_C15A11.6
uniprot id: Q93207
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE R13A5.9
gene id: 6239:CELE_R13A5.9
uniprot id: Q95Y88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

6239:CELE Y57A10C.6
gene id: 6239:CELE_Y57A10C.6
uniprot id: G5EDP2
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA (PubMed:9151950). Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone (PubMed:19496754, PubMed:19174521).
messages: Expressed in all larval stages with levels peaking at the L3 larval stage and decreasing in the adult.
messages: Expressed in intestine, hypodermis and body-wall muscle.
messages: In short-term culture, loss of the capacity to enter the dauer stage which is associated with a loss in the production of the dauer pheromone. In long-term culture, the capacity to induce the dauer stage is restored and is associated with the accumulation of long fatty acid chain ascarosides (PubMed:19174521). Intestinal expression of daf-22 restores the production of the pheromone (PubMed:19174521). Partial dauer phenotype in only half of mutants when the dauer pheromone is added exogenously (PubMed:19496754). In addition, mutants accumulate large fat granules in the intestine, have a decreased growth rate resulting in smaller adults and have a substantial reduction in brood size (PubMed:19496754).
messages: Inhibited by acetyl-CoA.
messages: Peroxisome

6239:CELE C46E1.2
gene id: 6239:CELE_C46E1.2
uniprot id: Q6DNF4
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in URX, AQR and PQR neurons.
messages: Heterodimer; heterodimerizes with gcy-35, and possibly with other soluble guanylate cyclases.
messages: Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen sensing in URX, AQR and PQR sensory neurons.
messages: Regulated by molecular oxygen, which binds to the heme binding site. Probably not activated by nitric oxide (NO) (By similarity).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE F02A9.1
gene id: 6239:CELE_F02A9.1
uniprot id: P34380
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47G6A.11
gene id: 6239:CELE_Y47G6A.11
uniprot id: Q9N3T8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

6239:CELE R08F11.1
gene id: 6239:CELE_R08F11.1
uniprot id: O01893
names: Function
names: Similarity
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

6239:CELE F59D6.3
gene id: 6239:CELE_F59D6.3
uniprot id: O16338
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE F53C11.3
gene id: 6239:CELE_F53C11.3
uniprot id: Q93761
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE T21H8.3
gene id: 6239:CELE_T21H8.3
uniprot id: Q94073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE F52B5.1
gene id: 6239:CELE_F52B5.1
uniprot id: G5EDF4
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

6239:CELE K02G10.6
gene id: 6239:CELE_K02G10.6
uniprot id: Q7Z139
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals deficient in HYL-2 show inability to adapt to oxygen deprivation as a result from the loss of ceramide synthase function.
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Catalyzes the acylation of sphingoid bases to form ceramides. Sphingolipids from Caenorhabditis elegans contain exclusively isosphingoid bases. Exhibits substrate preference for fatty acyl-coA chains containing 20 to 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by HYL-2, and seems to be affected by a pathway that is parallel to that involving daf-2.
messages: Membrane
messages: Strong expression in the gut, the posterior bulb of the pharynx, the hypoderm, and unidentified cells of the head and the tail.

6239:CELE ZK455.6
gene id: 6239:CELE_ZK455.6
uniprot id: G5ED47
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: In the presence of excess dietary zinc, reduced transcription of genes such as cdf-2, ttm-1b and mtl-1, which are required for zinc homeostasis, and retarded growth as compared to wild-type.
messages: Induced by high levels of zinc.
messages: Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated.
messages: Nucleus
messages: Weakly expressed in intestinal cells in the absence of zinc supplementation. Upon zinc supplementation, accumulates in alimentary tract cells, and it is mainly expressed in the intestine.

6239:CELE C10G8.7
gene id: 6239:CELE_C10G8.7
uniprot id: Q94166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

6239:CELE F20H11.2
gene id: 6239:CELE_F20H11.2
uniprot id: O01737
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SBNO family.
messages: Expressed in most cells of the embryo beginning from the 100-cell stage (at protein level) (PubMed:20230814). Expressed throughout larval development in the excretory system, anterior neurons and the hypodermis (at protein level) (PubMed:20230814). Expressed in vulval precursor cells and their descendants during the mid-larval stages and is highly expressed in the somatic gonad from the L3 larval stage to adulthood (at protein level) (PubMed:20230814).
messages: Expressed in the somatic gonad, neurons, hypodermal cells, seam cells, the excretory system, and intestinal cells (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic or larval lethality (PubMed:20230814). Surviving animals exhibit slow growth, gonad migration defects, vulval induction defects and reduced lin-3 expression (PubMed:20230814). Larvae that develop into adults are sterile, and only few produce embryos (PubMed:20230814). RNAi-mediated knockdown in males results in tail defects including underdeveloped tails, spicule defects and missing rays (PubMed:20230814). RNAi-mediated knockdown in a lin-3 e1417 mutant background abolishes vulval induction (PubMed:20230814). RNAi-mediated knockdown in a let-23 sa62 gain of function mutant background partially suppresses the multivulva phenotype in the let-23 mutant (PubMed:20230814). RNAi-mediated knockdown in a let-60 n1046 gain of function mutant background suppresses the multivulva phenotype in the let-60 mutant (PubMed:20230814).
messages: Transcriptional activator that functions upstream of the let-60/Ras and let-23/EGFR signaling pathways to positively regulate lin-3 expression and thereby promote vulval induction (PubMed:20230814). Plays a role in excretory duct development (PubMed:20230814). Plays a role in male tail development (PubMed:20230814).

6239:CELE F14H3.10
gene id: 6239:CELE_F14H3.10
uniprot id: O45364
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases (Probable). They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (Probable). Involved in the oxidative metabolism of thiabendazole (TBZ) (PubMed:23922869, PubMed:25406993). Catalyzes the conversion of TBZ to its hydroxylated form (PubMed:23922869, PubMed:25406993).
messages: Expressed in hypodermis, intestine and vulva upon thiabendazole (TBZ) exposure.
messages: RNAi-mediated knockdown causes a reduction in the quantity of a hydroxylated thiabendazole (TBZ) metabolite and probably its glucose conjugate.
messages: Thiabendazole (TBZ) is used as a broad-spectrum anthelmintic to treat parasitic nematode infections in humans and veterinary animals.
messages: Up-regulated in hypodermis, intestine and vulva following exposure to specific xenobiotics, such as thiabendazole (TBZ) (PubMed:23922869). Expression is up-regulated over 2000-fold by TBZ (PubMed:25406993).

6239:CELE C04E12.4
gene id: 6239:CELE_C04E12.4
uniprot id: O76677
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F44A2.1
gene id: 6239:CELE_F44A2.1
uniprot id: H2L031
uniprot id: Q27420
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

6239:CELE K08F4.6
gene id: 6239:CELE_K08F4.6
uniprot id: O16115
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE H16D19.1
gene id: 6239:CELE_H16D19.1
uniprot id: G5ED09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F57B7.4
gene id: 6239:CELE_F57B7.4
uniprot id: Q20930
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: First expressed in late embryos and continues through the adult stage. Observed on the surface of gonad, starting when distal tip cells migrate over the lateral hypodermis toward the dorsal muscles.
messages: Metalloprotease (PubMed:17491590, PubMed:18637819). Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis (PubMed:10864868, PubMed:15556863, PubMed:17491590, PubMed:19104038, PubMed:24318535, PubMed:26994289). Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane (PubMed:19104038). During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length (PubMed:26994289). Does not recruit fbl-1 to the pharynx basement membrane (PubMed:26994289).
messages: N-glycosylated by the COG complex; required for gonadal localization (PubMed:14688791, PubMed:16354716, PubMed:17761667, PubMed:17491590). N-glycosylation of the propeptide is required for gonadal localization but not for distal tip cell migration (PubMed:17491590). Required for the regulation of pharynx length (PubMed:26994289). N-glycosylation is not required for mig-17 secretion (PubMed:17491590).
messages: Secreted from muscle cells and functions in the basement membrane of the gonad to guide DTC migration (PubMed:10864868, PubMed:24318535). Localizes to the pharyngeal basement membrane (PubMed:26994289).
messages: The PLAC domain is required for distal tip cell migration but not for gonadal localization.
messages: The disintegrin domain is required for distal tip cell migration and partially for mig-17 localization to the gonad (PubMed:17491590). Required for the control of pharynx length (PubMed:26994289).
messages: The precursor is cleaved into the active mature form by autoproteolysis (PubMed:17491590, PubMed:18637819). Cleavage occurs after secretion and only during the L3-L4 larval stages (PubMed:18637819).
messages: The propeptide is required for localization to the gonad basement membrane.
messages: basement membrane

6239:CELE T05F1.10
gene id: 6239:CELE_T05F1.10
uniprot id: O18030
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE T01C3.7
gene id: 6239:CELE_T01C3.7
uniprot id: Q22053
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
messages: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.
messages: Expressed throughout embryonic development and in adults. During embryogenesis, expressed from the 2-cell stage and persists throughout development in nucleoli containing cells.
messages: RNAi-mediated knockdown results in reduced 26S ribosomal RNA (rRNA) expression. RNAi-mediated knockdown in a ncl-1 (e1942) mutant background suppresses the enlarged nucleoli phenotype in the single ncl-1 mutant. RNAi-mediated knockdown in a ncl-1 (e1942) mutant background suppresses the increased 26S rRNA expression in the single ncl-1 mutant.
messages: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Plays a role in modulation of nucleolus size most likely through regulating the ribosomal RNA (rRNA) pool (PubMed:26492166).
messages: nucleolus
messages: nucleoplasm

6239:CELE F07C4.10
gene id: 6239:CELE_F07C4.10
uniprot id: P91215
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE D1037.2
gene id: 6239:CELE_D1037.2
uniprot id: Q9TYS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R12B2.1
gene id: 6239:CELE_R12B2.1
uniprot id: P45897
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Involved in TGF-beta pathway.
messages: Nucleus

6239:CELE F54A5.3
gene id: 6239:CELE_F54A5.3
uniprot id: Q9TYT3
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in hypodermis, intestine, head and tail neurons, pharynx, gonads, vulva and body muscles.
messages: Interacts (via PID domain) with daf-2 (via cytoplasmic domain) (PubMed:18832074). Interacts with mek-1; the interaction is independent of mek-1 catalytic activity and is constitutive (PubMed:18832074, PubMed:18809575). Interacts (via N-terminus) with mlk-1 (via NPQY motif when phosphorylated on tyrosine residue) (PubMed:18809575, PubMed:23072806). Does not interact with jkk-1 or sek-1 (PubMed:18809575). Interacts (via SH2 domain) with svh-2 (PubMed:27984580). Interacts with svh-4 (PubMed:27984580).
messages: Nucleus
messages: Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1 (PubMed:18832074, PubMed:18809575, PubMed:22916022). In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2 (PubMed:18832074, PubMed:22916022). Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway (PubMed:18832074, PubMed:22916022). Plays a role in maintaining gonadal basement membrane integrity through activation of the JNK pathway components mek-1 and jnk-1 (PubMed:22916022). Involved in the response to several environmental stresses including heavy metal ions (Cu(2+) and Cd(2+)), heat, oxidative and protein misfolding (ER) stresses (PubMed:18832074, PubMed:18809575). Plays a role in gonad and germline development following the L1 diapause (PubMed:24746511). Plays a role in life span and egg laying (PubMed:18832074, PubMed:23072806). Plays a role in axon regeneration after injury (PubMed:23072806, PubMed:27984580).

6239:CELE C17E4.9
gene id: 6239:CELE_C17E4.9
uniprot id: Q93235
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Defecation defects.
messages: Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

6239:CELE Y53H1A.5
gene id: 6239:CELE_Y53H1A.5
uniprot id: Q5ZEP9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (nfya-2-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the nfya-2-NF-Y complex, may repress the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492).
messages: Expressed at all developmental stages (PubMed:17574230). Highly expressed in the intestine at all developmental stages (PubMed:17574230).
messages: Forms a heterotrimeric transcription factor complex (nfya-2-NF-Y complex) composed of nfya-2, nfyb-1 and nfyc-1 (PubMed:17574230). Interacts with the nfyb-1 and nfyc-1 dimer; the interaction is required for subsequent binding to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230). Does not interact with either nfyb-1 or nfyc-1 in their monomeric form (PubMed:17574230).
messages: Highly expressed in certain parts of the gonads (PubMed:15704008). Expressed in the spermatheca, intestine and in some neurons in the head (PubMed:17574230). Not expressed in the intestine, the hypodermis, body wall muscle surrounding the pseudocoelomic space, secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008).
messages: Nucleus
messages: RNAi-mediated knockdown results in weak ectopic expression of tbx-2 in seam cells of the head in young adults.

6239:CELE R74.1
gene id: 6239:CELE_R74.1
uniprot id: Q09996
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress.

6239:CELE ZC482.6
gene id: 6239:CELE_ZC482.6
uniprot id: O18277
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F59E12.5
gene id: 6239:CELE_F59E12.5
uniprot id: Q95QZ9
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPL4 family.
messages: Cytoplasm
messages: Forms a complex composed of ubxn-3, ufd-1, npl-4.2 and cdc-48.1; within the complex, interacts with ufd-1 and ubxn-3 (By similarity). Interacts with ufd-1 (PubMed:16647269). Interacts with elc-1/elongin C; the interaction may mediate the interaction between the npl-4-ufd-1-cdc-48 complex and the E3 ubiquitin ligase cul-2 complex (By similarity).
messages: In association with ufd-1 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338). During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).
messages: Nucleus
messages: Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 causes embryonic lethality (PubMed:16647269, PubMed:26842564). In embryos, DNA replication is partially impaired causing a delay in S phase progression in P0, AB and P1 cells; simultaneous RNAi-mediated knockdown of DNA replication checkpoint kinases chk-1 or atl-1 suppresses the delay in S phase (PubMed:18728180, PubMed:26842564). During S phase, prevents DNA replication licensing factor cdt-1 down-regulation and causes cdt-1 accumulation on mitotic chromosomes (PubMed:21981920). Impairs dissociation from the chromatin of components of the DNA replication machinery, including cdc-45, GINS complex component sld-5 and CMG helicase component mcm-3, resulting in their persistent association with chromatin throughout embryonic mitosis (PubMed:21981920, PubMed:26842564, PubMed:28368371). Abnormal ubxn-3 localization into punctate structures in the nucleus (PubMed:26842564). Reduces ufd-1 expression in embryos (PubMed:21981920, PubMed:26842564). Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 in adults causes a proliferation arrest of mitotic germline cells in the gonad with formation of rad-51 foci on chromatin (PubMed:18728180). Induces the unfolded protein response and increases sensitivity to tunicamycin-induced ER stress (PubMed:16647269). Causes accumulation of misfolded protein cpl-1 in the ER (PubMed:22768338).
messages: There is another gene, npl-4.1, which has a 99% identical sequence making it difficult to identify the specific function for each protein.

6239:CELE F35G12.3
gene id: 6239:CELE_F35G12.3
uniprot id: G5ECQ3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: No obvious phenotype. RNAi-mediated knockdown suppresses the egg laying defect of lin-12 n302 mutant. A similar phenotype occurs in a lin-12 and sel-5 double mutant.
messages: Serine/threonine-protein kinase which may play a role in lin-12-mediated cell-fate decisions.

6239:CELE Y49E10.14
gene id: 6239:CELE_Y49E10.14
uniprot id: Q94131
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Disrupts blastomere cell fate. Excessive pharyngeal cells produced during embryogenesis. Reduced expression of nos-2 in P4 germline blastomeres and absence of nos-2 protein.
messages: Expressed in 1, 2 and 4-cell embryos (at protein level) (PubMed:10983990, PubMed:30279189). Expression increases between P0 (the zygote) and P2 blastomeres due to its asymmetric segregation in P1 and P2 blastomeres, its degradation in somatic cells and its translation in the P lineage (at protein level) (PubMed:30279189).
messages: Interacts with hda-1, let-418 and mep-1. Interacts (via C terminus) with cit-1.1 (via C terminus).
messages: Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex.
messages: Nucleus
messages: The C3H1-type 1 domain is required for degradation in somatic blastomeres.
messages: The C3H1-type 2 domain targets the protein to P granules, is involved in germ cell positioning in embryos and is required for default nos-2 expression.
messages: centrosome
messages: spindle

6239:CELE F45E4.11
gene id: 6239:CELE_F45E4.11
uniprot id: O44130
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H06H21.3
gene id: 6239:CELE_H06H21.3
uniprot id: Q9TXU7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

6239:CELE F44E7.4
gene id: 6239:CELE_F44E7.4
uniprot id: O16249
uniprot id: Q6A598
uniprot id: Q8IA89
uniprot id: Q8MXK1
names: Similarity
messages: Belongs to the peptidase M16 family.

6239:CELE C01B12.5
gene id: 6239:CELE_C01B12.5
uniprot id: O17205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE F40F9.5
gene id: 6239:CELE_F40F9.5
uniprot id: Q20236
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C50B6.4
gene id: 6239:CELE_C50B6.4
uniprot id: O17686
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F32A5.3
gene id: 6239:CELE_F32A5.3
uniprot id: P52716
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE F48F7.7
gene id: 6239:CELE_F48F7.7
uniprot id: Q20577
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y43D4A.1
gene id: 6239:CELE_Y43D4A.1
uniprot id: Q9NF30
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F28D1.9
gene id: 6239:CELE_F28D1.9
uniprot id: Q19878
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F23B12.7
gene id: 6239:CELE_F23B12.7
uniprot id: Q19753
names: Similarity
messages: Belongs to the CBF/MAK21 family.

6239:CELE F46F11.4
gene id: 6239:CELE_F46F11.4
uniprot id: P91302
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expression increased by citrate dietary supplementation.
messages: Interacts with dve-1; the interaction occurs in a mitochondrial stress-dependent manner.
messages: Involved in the mitochondrial unfolded protein response (mtUPR) (PubMed:17925224). Plays a role in modulation of lipid metabolism in response to the citrate-induced mtUPR, acting upstream of transcription factor nhr-80 (PubMed:35021096).
messages: RNAi-mediated knockdown inhibits expression of hsp-60 when adults are exposed to conditions causing mitochondrial unfolded protein stress.

6239:CELE C32D5.5
gene id: 6239:CELE_C32D5.5
uniprot id: Q09265
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3) (PubMed:22393255, PubMed:23028348). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes (PubMed:26641248, PubMed:23028348, PubMed:22393255). Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442).
messages: Mutant animals exhibit a lack of di- and trimethylation (H4K20me2/me3) and an increase of monomethylation of 'Lys-20' (H4K20me1) of histone H4 on autosomes, leading to equal H4K20me1 levels on autosomes relative to X chromosomes (PubMed:22393255, PubMed:23028348, PubMed:26641248). Decreased expression of autosomal genes (PubMed:26641248). Increase in 'Lys-16' acetylation of histone H4 (H4K16ac) on hermaphrodite X chromosomes (PubMed:22393255). Increase in binding of the RNA Pol II large subunit ama-1 on X chromosome gene promoters relative to autosomes (PubMed:26641248). In a dpy-21 mutant background, RNAi-mediated knockdown leads to embryonic lethality (PubMed:23028348). In the TOR complex 2 mutant background rict-1, suppresses the growth delay and elevated body fat index (PubMed:23884442).
messages: Nucleus

6239:CELE M79.1
gene id: 6239:CELE_M79.1
uniprot id: P03949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development (PubMed:27780040). Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis (PubMed:27780040). Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024).
messages: Interacts (via SH2 and SH3 domains) with mig-13; the interaction is direct. May interact with soem-1.

6239:CELE Y69H2.2
gene id: 6239:CELE_Y69H2.2
uniprot id: Q9XTS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F32D1.3
gene id: 6239:CELE_F32D1.3
uniprot id: O16296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

6239:CELE F52F12.8
gene id: 6239:CELE_F52F12.8
uniprot id: Q7YX19
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE BE10.2
gene id: 6239:CELE_BE10.2
uniprot id: O17554
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. TMEM195 subfamily.
messages: Endoplasmic reticulum membrane
messages: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.

6239:CELE C43C3.1
gene id: 6239:CELE_C43C3.1
uniprot id: Q09501
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE F55G1.9
gene id: 6239:CELE_F55G1.9
uniprot id: Q20848
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

6239:CELE T23F2.4
gene id: 6239:CELE_T23F2.4
uniprot id: Q22701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE D1054.13
gene id: 6239:CELE_D1054.13
uniprot id: Q18953
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

6239:CELE C27C12.2
gene id: 6239:CELE_C27C12.2
uniprot id: Q18250
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Expressed in sheath cells and distal tip cells of the somatic gonad, as well as in the intestine and sperm (at protein level) (PubMed:20736289). Expression not observed in oocytes (at protein level) (PubMed:20736289).
messages: Nucleus
messages: RNAi-mediated knockdown causes abnormalities in oocyte development, including degrading oocytes in the proximal gonadal arm and ectopic developing oocytes in the distal arm (PubMed:20736289). RNAi-mediated knockdown targeted to the soma, on an rrf-1 mutant background, exhibits only a slight increase in the frequency of oocyte defects (PubMed:20736289).
messages: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in oocyte development, acting cell-autonomously in the somatic gonad (PubMed:20736289). Involved in negative regulation of oocyte MAPK activation and inhibits oocyte maturation and ovulation (PubMed:20736289).
messages: perinuclear region

6239:CELE C06G3.11
gene id: 6239:CELE_C06G3.11
uniprot id: Q17754
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim-9/tin-9.1 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
messages: Worms display a small body size, reduced number of progeny produced and partial embryonic lethality due to defects in import of proteins into mitochondria.

6239:CELE Y32F6B.2
gene id: 6239:CELE_Y32F6B.2
uniprot id: G5EC02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

6239:CELE Y57E12AM.1
gene id: 6239:CELE_Y57E12AM.1
uniprot id: Q965T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE C38C6.4
gene id: 6239:CELE_C38C6.4
uniprot id: O45300
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y116A8C.4
gene id: 6239:CELE_Y116A8C.4
uniprot id: Q9U2T1
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE C09B8.1
gene id: 6239:CELE_C09B8.1
uniprot id: Q17848
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

6239:CELE T01B7.3
gene id: 6239:CELE_T01B7.3
uniprot id: Q22045
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

6239:CELE F35E8.12
gene id: 6239:CELE_F35E8.12
uniprot id: O45449
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y97E10B.1
gene id: 6239:CELE_Y97E10B.1
uniprot id: Q965R1
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C30B5.3
gene id: 6239:CELE_C30B5.3
uniprot id: Q18317
names: Function
names: Tissue Specificity
messages: Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis.
messages: Expressed specifically in the spermatogenic germ line.

6239:CELE C27H5.5
gene id: 6239:CELE_C27H5.5
uniprot id: P34803
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE C36B1.12
gene id: 6239:CELE_C36B1.12
uniprot id: Q564X0
uniprot id: Q564X1
uniprot id: Q93346
names: Similarity
messages: Belongs to the peptidase A22B family.

6239:CELE K02B9.4
gene id: 6239:CELE_K02B9.4
uniprot id: B7WN96
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in embryonic and in larval L1, L2, L3 and L4 stages, and in immature adults (PubMed:10191044). Earliest expression detected in eight cells on the posterior dorsal surface of the embryo, probably granddaughters of Cpaa and Caaa, approximately 240 min after the first cell cleavage (at protein level) (PubMed:10191044). At approximately 260 min after the first cleavage, expressed in cells on the dorsal, and ventrolateral, surfaces of the embryo; these are probably hypodermal and ventral hypodermal cells (P cells), respectively (PubMed:10191044). Expressed in comma stage embryos, at about 350 min, in all the dorsal (hyp-7) and ventral (P1/2-P11/12) hypodermal cells in the main body region; also in hypodermal cells of the head (hyp-4, hyp-5, and hyp-6) and tail (hyp-8, hyp-9, hyp-10, and hyp-11) (PubMed:10191044). No expression is seen in the lateral hypodermal cells (seam cells; V1-V6, H0, H1, H2, and T) or the minor hypodermal cells of the head (hyp-1, hyp-2, and hyp-3) (PubMed:10191044). Expressed from the 3-fold stage of embryogenesis onward in two cells, probably the vpi3 cells of the pharyngeal-intestinal valve, immediately anterior to the gut (at protein level) (PubMed:10191044). Also expressed in five cells immediately posterior to the gut, probably the intestinal-rectal valve cells (virL and virR) and the rectal epithelial cells (rect D, rect VL, and rect VR) (at protein level) (PubMed:10191044).
messages: Expressed in head, trunk and tail (PubMed:18662544). Expression decreases with age in the hypodermal cells and the pharyngeal-intestinal valve cells in the head, eventually showing little or no expression in about 14 day old worms (PubMed:18662544). Expressed in hypodermal, but not in intestinal, cells at 1 day of age (PubMed:22001047). Expression in the hypodermal and intestinal cells in the trunk region decreases quickly between day 3 and day 5 of adulthood (PubMed:18662544). Expression in the tail between days 3 and 14 stays approximately uniform (PubMed:18662544).
messages: Expressed in the intestine (PubMed:18662544). However, others have been unable to detect intestinal expression (PubMed:22001047). Based on lifespan assays conducted with a putative null allele, elt-3(vp1), represses longevity caused by a daf-2(e1370) mutant background (PubMed:18662544). However, this repression could not be reproduced (PubMed:22001047). Based on further analysis, the failure to reproduce seems to be due to a novel, unknown, mutation which arose in the daf-2(e1370) mutant background in one lab, but not the other (PubMed:23262285).
messages: Interacts with skn-1; interaction may enhance transcriptional activation of target genes.
messages: Nucleus
messages: RNAi-mediated knockdown reduces expression of ugt-9 about 74% at 3 days and 95% at 7 days after adulthood (PubMed:18662544). Suppresses the longevity of long-lived mutants daf-2 or eat-2 (PubMed:18662544). Suppresses transcription of the gst-4 gene in a brap-2 mutant background (PubMed:28600327).
messages: Repressed during adulthood by normal aging.
messages: Transcription factor (PubMed:18662544, PubMed:28600327). Required, in concert with signal transducer and transcription factor sta-2, for up-regulation of the vacuolar H(+)-ATPase and acceleration of lysosome maturation at molt (PubMed:31735670). Involved in regulating hypodermal development, perhaps acting downstream of transcription factor elt-1 (PubMed:11259601). Modulates environmentally induced changes in collagen gene expression, including rol-6, sqt-1, lon-3, and dpy-13 (PubMed:32229533). Involved in regulating expression of various genes, including gst-4, sod-3, ugt-9, and col-144 (PubMed:18662544, PubMed:28600327). In response to oxidative stress, required to up-regulate expression of gst-4 mRNA (PubMed:28600327). Regulated by the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:18662544). Plays a role in longevity (PubMed:18662544, PubMed:23262285). May regulate the expression of genes that control sensitivity to osmotic stress, in conjunction with the GATA region-binding transcription factor elt-2 (PubMed:20126308). May form a transcriptional circuit with GATA factors egl-18 and elt-6 (PubMed:18662544).

6239:CELE T06E4.3
gene id: 6239:CELE_T06E4.3
uniprot id: Q22258
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Expressed at all larval stages and is expressed at higher level in the adult.
messages: Nucleus
messages: RNAi-mediated knockdown results in DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the checkpoint response to double-strand breaks (DSBs) after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1/p53 pathway (PubMed:12747829, PubMed:16319925). In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).

6239:CELE C47F8.2
gene id: 6239:CELE_C47F8.2
uniprot id: O62112
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R06B9.6
gene id: 6239:CELE_R06B9.6
uniprot id: Q7YWX7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basal cell membrane
messages: Belongs to the wntless family.
messages: Cell membrane
messages: Early endosome membrane
messages: Embryonic lethal with severely defective embryonic morphogenesis with no endoderm and excess mesoderm (PubMed:9288749, PubMed:18160347). In addition, embryos have defective mitotic spindle orientation in the 8-cell stage ABar blastomere (PubMed:9288749, PubMed:16678095).
messages: Expressed in posterior regions at the comma stage of embryogenesis, during larval development and in adults.
messages: Expressed in the tail hypodermis, stomatointestinal muscle, the mesoblast cell M and its descendants, CAN neurons, the developing vulva, the pharynx and the pharyngeal intestinal valve.
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20 (PubMed:18160346, PubMed:18160347, PubMed:21076391). Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function (PubMed:18160346, PubMed:18160347, PubMed:21076391). Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex (PubMed:21076391). Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288749, PubMed:16678095). Functions during vulval development, playing a role in vulval precursor cell fate specification (PubMed:11063687, PubMed:18077322). During development, specifically regulates the migration of HSN neurons, the left Q neuroblast (QL) and its descendants and the distal tip cells of the gonads (PubMed:8898225, PubMed:10388818, PubMed:11063687, PubMed:18160346, PubMed:18160347). Positioning of Q neuroblasts may be both dependent and independent of hox gene mab-5 (PubMed:8898225). Involved in establishing ALM and PLM neuronal cell polarity (PubMed:18160346).

6239:CELE F28E10.2
gene id: 6239:CELE_F28E10.2
uniprot id: U4PAZ4
uniprot id: U4PLF0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C50E10.5
gene id: 6239:CELE_C50E10.5
uniprot id: A3QMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C44C1.4
gene id: 6239:CELE_C44C1.4
uniprot id: H2KYN0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

6239:CELE C40H1.6
gene id: 6239:CELE_C40H1.6
uniprot id: Q03598
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E2-like enzyme which forms an intermediate with ufm-1 (PubMed:23449979). The intermediate is formed via a thioester linkage (By similarity).
messages: Expressed in the intestine.
messages: Interacts with uba-5.

6239:CELE T27B7.4
gene id: 6239:CELE_T27B7.4
uniprot id: O16662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK970.6
gene id: 6239:CELE_ZK970.6
uniprot id: Q23682
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in both ASEL and ASER neurons during early embryonic stages and becomes specifically expressed in ASER neuron in early larval stage.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses to salt ions mediated by ASE sensory neurons (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE C27H5.3
gene id: 6239:CELE_C27H5.3
uniprot id: Q18265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

6239:CELE ZK632.10
gene id: 6239:CELE_ZK632.10
uniprot id: P34655
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE F59F5.4
gene id: 6239:CELE_F59F5.4
uniprot id: Q21047
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F10E9.8
gene id: 6239:CELE_F10E9.8
uniprot id: P34402
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with hyls-1; leading to hyls-1 localization into newly forming centrioles.
messages: Localizes to centrosomes both in sperm and in the syncytial part of the gonad. Staining in the gonad disappears as the meiotic nuclei cellularizes to form oocytes, presumably marking the point at which the centrioles are lost during oogenesis. In newly fertilized embryos, it is localized to a discrete spot near the sperm-derived pronucleus. Then, it remains attached to the centrosome throughout the rest of development.
messages: Required for centrosome duplication. Plays a central role in determining centrosome size.
messages: centrosome

6239:CELE C24B9.10
gene id: 6239:CELE_C24B9.10
uniprot id: O76439
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T09E11.10
gene id: 6239:CELE_T09E11.10
uniprot id: O02310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C26H9A.1
gene id: 6239:CELE_C26H9A.1
uniprot id: B2MZD0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in hypodermal cells in L1 larvae (PubMed:11441002). No expressed in embryos (PubMed:11441002).
messages: Expressed in uterus.
messages: Membrane
messages: RNAi-mediated knockdown does not affect embryonic or larval development.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE W04G3.4
gene id: 6239:CELE_W04G3.4
uniprot id: Q23165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

6239:CELE R05F9.13
gene id: 6239:CELE_R05F9.13
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE Y56A3A.2
gene id: 6239:CELE_Y56A3A.2
uniprot id: Q9U227
names: Similarity
messages: Belongs to the peptidase M50A family.

6239:CELE F58E6.13
gene id: 6239:CELE_F58E6.13
uniprot id: A0A061ACS5
uniprot id: H2FLH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y62E10A.8
gene id: 6239:CELE_Y62E10A.8
uniprot id: Q9U1X7
names: Similarity
messages: Belongs to the phosducin family.

6239:CELE C44C3.1
gene id: 6239:CELE_C44C3.1
uniprot id: P91160
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C36B1.1
gene id: 6239:CELE_C36B1.1
uniprot id: G5EDV5
uniprot id: G5EF89
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE F59B2.13
gene id: 6239:CELE_F59B2.13
uniprot id: A0A1N7SYQ7
uniprot id: P34488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE Y45F10B.10
gene id: 6239:CELE_Y45F10B.10
uniprot id: O62471
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the nerve ring, neurons of the lateral and ventral ganglia, including the sensory neuron ADL, neurons in the retrovesicular ganglion and two neurons in the lumbar ganglion, PVQ and the sensory neuron PHB (PubMed:14988722). Expressed in ASH nociceptive chemosensory neurons (PubMed:14988722, PubMed:26976437). Not expressed in ASK sensory neurons (PubMed:14988722).
messages: Involved in the avoidance response to the noxious chemicals and repellents such as quinine in ASH and ADL sensory neurons (PubMed:14988722). In response to the noxious chemical quinine, promotes dauer formation induced by pheromones such as the ascaroside ascr#3 in ASH nociceptive neurons (PubMed:26976437).
messages: Nucleus
messages: Perikaryon
messages: axon
messages: cytosol
messages: dendrite

6239:CELE F43C1.4
gene id: 6239:CELE_F43C1.4
uniprot id: Q09565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K03A11.3
gene id: 6239:CELE_K03A11.3
uniprot id: G5EE18
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Expressed from 172 minutes after the first cleavage, in the ABalaappa cell and continuing in its daughters, and in the cholinergic motor neuron M4 from mid-embryogenesis through to adult stages.
messages: Nucleus
messages: Probable transcription factor that regulates neuronal differention, including synapse assembly of the cholinergic motor neuron M4 (PubMed:24690231, PubMed:25474681). Activates expression of growth factor, neuropeptide and transcription factor genes, such as TGF-beta dbl-1, FMRFamide-like flp-5 and transcription repressor zag-1, in the M4 neuron (PubMed:24690231, PubMed:25474681). Required for pharynx peristalsis (PubMed:18161854).
messages: Reduced pharynx pumping rate and abnormal isthmus peristalses in L1 stage larvae (PubMed:18161854). Feeding defects, characterized by a stuffed pharynx, as a result of ingested E.coli packing the lumen of the corpus and anterior isthmus in L4 stage larvae (PubMed:18161854). Defects in pharyngeal g1 gland cell morphology (PubMed:24690231). Reduced expression of TGF-beta, dbl-1, in the cholinergic motor neuron M4, but normal expression of other markers of differentiation, such as serotonin receptor ser-7b and the vesicular acetylcholine transporter unc-17 (PubMed:18161854).

6239:CELE F48C1.7
gene id: 6239:CELE_F48C1.7
uniprot id: P54217
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during spermatogenesis.
messages: Expressed in mature sperm.
messages: Paternally sperm-supplied factor required for embryogenesis (PubMed:8565851, PubMed:20971008). Plays a role in preventing polyspermy possibly by promoting the formation of a continuous and cohesive eggshell chitin layer (PubMed:20971008).
messages: Worms fail to complete meiosis, form a weak eggshell, fail to orient properly the first mitotic spindle and fail to undergo cytokinesis.
messages: perinuclear region

6239:CELE F37H8.4
gene id: 6239:CELE_F37H8.4
uniprot id: O17863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE R53.4
gene id: 6239:CELE_R53.4
uniprot id: Q22021
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE B0495.1
gene id: 6239:CELE_B0495.1
uniprot id: Q09213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T07D1.4
gene id: 6239:CELE_T07D1.4
uniprot id: Q10572
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in males and hermaphrodites throughout development (PubMed:17923701, PubMed:9927456). Expressed in early embryos before morphogenesis (PubMed:17923701). In hermaphrodite embryos, first expressed at the 8-16 cell stage of development with expression peaking by the 100-cell stage (PubMed:9217163). Not expressed at the 550-cell stage of embryogenesis (PubMed:9217163).
messages: In males and hermaphrodites expressed in a subset of cells in the head and tail (PubMed:9927456). Expressed in the pharynx, intestine and in muscles from the vulva and body wall.
messages: Interacts with sup-12.
messages: Males and hermaphrodites are viable and there is no change in brood size (PubMed:9217163, PubMed:17720939, PubMed:33372658). In a sex-1(y263) mutant background or a sex-1 RNAi mutant background, males are viable, but hermaphrodites have highly reduced viability due to failure of the dosage compensation complex to assemble on X chromosomes, and the surviving animals show a reduction in brood size (PubMed:17720939, PubMed:16139225, PubMed:33372658). RNAi-mediated knockdown results in a 63% reduction in the number of eggs produced (PubMed:11303786). RNAi-mediated knockdown together with sex-1 results in hermaphrodite embryonic lethality (PubMed:21471153). This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153).
messages: Nucleus
messages: RNA-binding protein that regulates tissue-specific alternative splicing events by binding to 5'-UGCAUG-3' and 5'-GCACG-3' elements (PubMed:17060915, PubMed:17923701, PubMed:23468662, PubMed:33372658). Also binds to poly(A), poly(G), poly(C), or poly(U) stretches of RNA (PubMed:9927456). Plays a role in the sex determination pathway and X chromosome dosage compensation, and together with sex-1 is involved in making the distinction between one and two X-chromosomes (PubMed:7821230, PubMed:21471153, PubMed:23666922, PubMed:9217163, PubMed:9927456, PubMed:16139225, PubMed:17720939, PubMed:33372658). Binds to 5'-GCAUG-3' and 5'-GCACG-3' elements in intron 6 of the pre-mRNA of the sex-determining factor xol-1 to promote its alternative splicing and together with sex-1 negatively regulates the expression of xol-1 to promote hermaphrodite development (PubMed:9217163, PubMed:33372658). Negatively regulates the expression of the active isoform of xol-1 (isoform b) by promoting intron 6 retention and the deletion of exon 7 coding sequences in hermaphrodite embryos (PubMed:33372658). Furthermore, binding to the pre-mRNA of xol-1 can also direct the use of an alternative 3' splice site enabling the xol-1 transcript to be trans-spliced to unrelated genes on chromosome 2, which also leads to xol-1 exon 7 deletion (PubMed:33372658). Does not seem to regulate the retention of introns 1 to 5 of xol-1 pre-mRNA (PubMed:33372658). Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939). Binds to 5'-UGCAUG-3' elements in intron 7 of the pre-mRNA of unc-32 to promote its alternative splicing in neuronal tissues (PubMed:23468662). Binds to 5'-UGCAUG-3' elements in intron 4 of the pre-mRNA of egl-15 to promote its alternative splicing in body wall muscle tissues (PubMed:17060915). Promotes binding of RNA-binding protein sup-12 to target RNA (PubMed:17923701). Plays a role in male mat…

6239:CELE K10D2.3
gene id: 6239:CELE_K10D2.3
uniprot id: Q09409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

6239:CELE F40G12.1
gene id: 6239:CELE_F40G12.1
uniprot id: Q20249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y43D4A.4
gene id: 6239:CELE_Y43D4A.4
uniprot id: Q9NF27
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y94H6A.9
gene id: 6239:CELE_Y94H6A.9
uniprot id: Q9N2W5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NSFL1C family.
messages: Cytoplasm
messages: Expressed in embryos, larvae and adults.
messages: Expressed in the germline (at protein level) (PubMed:20977550). Expressed in spermatocytes but not in mature sperm (at protein level) (PubMed:20977550). Ubiquitously expressed (PubMed:17498661). Predominantly expressed in the spermatheca (PubMed:17498661).
messages: Interacts with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus) (PubMed:20977550, PubMed:23649807). Interacts with kinase air-1 (PubMed:23649807).
messages: Nucleus
messages: RNAi-mediated knockdown does not cause any visible phenotype (PubMed:20977550). Causes 82 percent embryonic lethality (PubMed:23649807). One-cell embryos have defects in pronuclei positioning and spindle orientation during prophase; however the duration of cell division and establishment of embryo polarity are normal (PubMed:23649807). During prophase, increases active air-1 and to a lesser extent zyg-9, plk-1 and spd-2, accumulation at centrosomes, centrosome size and microtubule growth rate (PubMed:23649807). Simultaneous RNAi-mediated knockdown of air-1 restores normal pronuclei positioning and spindle orientation but not embryonic lethality (PubMed:23649807). Simultaneous RNAi-mediated knockdown of ubxn-1 and ubxn-3, causes 50 percent embryonic lethality (PubMed:20977550). The surviving hermaphrodite progeny are sterile due to a lack of sperm (PubMed:20977550). Abnormal accumulation of sex determination terminal factor tra-1 (PubMed:20977550). Germline development is normal (PubMed:20977550). In males, sperm production is normal (PubMed:20977550).
messages: Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity (PubMed:20977550). Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1 (PubMed:20977550). Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation in the one-cell embryo by controlling centration and rotation of the pronuclei-centrosome complex in prophase (PubMed:23649807).
messages: centrosome
messages: perinuclear region

6239:CELE Y54G11A.11
gene id: 6239:CELE_Y54G11A.11
uniprot id: Q9XVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

6239:CELE F25E2.5
gene id: 6239:CELE_F25E2.5
uniprot id: Q95QI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with R-SMADs daf-8 and daf-14 (PubMed:20081192). Interacts with daf-14 in a daf-8 dependent manner (PubMed:20081192). May interact with daf-5 (PubMed:14681186).
messages: Nucleus
messages: Transcriptional regulator and common SMAD (co-SMAD), required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:9334330). Probable component of transcriptional regulatory complex with SMAD protein daf-5 (PubMed:14681186). Acts antagonistically to SMAD signaling downstream of TGF-beta-like daf-7 signaling (PubMed:20081192). Binds to the 5'-GTCTG-3' motif found in regulatory regions and may modulate the expression of genes involved in TGF-beta-like daf-7 and Notch lag-2 signaling (PubMed:20081192, PubMed:9834189, PubMed:28811311). May regulate gene expression outside the dauer pathway (PubMed:9834189).

6239:CELE Y37D8A.23
gene id: 6239:CELE_Y37D8A.23
uniprot id: G5EDB7
uniprot id: Q8I4D9
uniprot id: Q8I4E0
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE F54B11.1
gene id: 6239:CELE_F54B11.1
uniprot id: Q20744
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T23F2.1
gene id: 6239:CELE_T23F2.1
uniprot id: G5ECB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

6239:CELE C36B7.6
gene id: 6239:CELE_C36B7.6
uniprot id: Q966P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

6239:CELE F37B4.7
gene id: 6239:CELE_F37B4.7
uniprot id: O45166
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane
messages: Unlike folt-1, does not appear to act as a folate transporter.

6239:CELE F31C3.5
gene id: 6239:CELE_F31C3.5
uniprot id: O62193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

6239:CELE K10B3.1
gene id: 6239:CELE_K10B3.1
uniprot id: G4S035
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE F26F4.1
gene id: 6239:CELE_F26F4.1
uniprot id: Q19824
names: Similarity
messages: Belongs to the GET4 family.

6239:CELE C35D10.13
gene id: 6239:CELE_C35D10.13
uniprot id: Q18490
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the complex interacts with erh-2 (PubMed:31216475, PubMed:31147388). Within the complex interacts with pid-3 and tofu-6 (PubMed:31216475). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388).
messages: Component of the tost-1 variant of the PETISCO complex which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the complex acts as an adapter which binds to the complex via erh-2 (PubMed:31147388). Does not seem to play a role in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388). May inhibit 21U-RNA accumulation (PubMed:31216475). Required for chromosome segregation and cell division in early embryos (PubMed:31216475).
messages: Cytoplasm
messages: During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos.
messages: Expressed in the germline.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:31147388). RNAi-mediated knockdown results in chromosome segregation and cell division defects in early embryos (PubMed:31216475). RNAi-mediated knockdown enhances the activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown disrupts the localization of tofu-6 to the perinuclear region of the germline (PubMed:31216475). RNAi-mediated knockdown results in larger tofu-6-, erh-2- and pid-3-expressing foci (PubMed:31216475).

6239:CELE F42F12.2
gene id: 6239:CELE_F42F12.2
uniprot id: G5EDQ9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in PVT neurons and weakly in some head neurons.
messages: Expression begins at the late L1 larval stage.
messages: No visible phenotype (PubMed:19737747, PubMed:22829780). No defect in the positioning of ASI and ASH neuron cell bodies (PubMed:22829780). No defect in the positioning of PQV, PVP, RMEV, HSN adn AVK axons in the ventral nerve cord (PubMed:19737747). In a zig-1, zig-3, zig-4 or zig-5 or zig-8 mutant background, cell body positioning of ASI and ASH head neurons is normal (PubMed:22829780).
messages: Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
messages: Secreted

6239:CELE ZK1290.3
gene id: 6239:CELE_ZK1290.3
uniprot id: P18831
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE K09B3.1
gene id: 6239:CELE_K09B3.1
uniprot id: Q94268
uniprot id: U4PQR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C47A10.1
gene id: 6239:CELE_C47A10.1
uniprot id: G5EG58
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK673.7
gene id: 6239:CELE_ZK673.7
uniprot id: Q09665
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the troponin C family.
messages: Pharyngeal muscle.
messages: This protein binds two calcium ions.

6239:CELE C10F3.5
gene id: 6239:CELE_C10F3.5
uniprot id: G8JY24
uniprot id: Q27873
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
messages: Monomer.
messages: cytosol

6239:CELE F15B9.7
gene id: 6239:CELE_F15B9.7
uniprot id: G5EDK5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation (PubMed:20876647, PubMed:22442082, PubMed:23376536, PubMed:28846083). Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring (PubMed:28846083). Promotes motorneuron development by positively regulating the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PubMed:23376536). Plays a role in synaptogenesis by regulating synaptic vesicle accumulation at GABAergic and cholinergic neuromuscular junctions (PubMed:22442082).
messages: Expressed in a region of neuropil around the nerve ring and the ventral cord (at protein level) (PubMed:22442082). Expressed in the head, tail, ventral cord, nerve ring and neurons including HSN neurons (PubMed:20876647). Expressed in DA, VA, and VB and weakly in the DB cholinergic neurons (PubMed:22442082). Not expressed in ventral D-type GABAergic motorneurons (PubMed:22442082).
messages: Expressed throughout development (PubMed:20876647). In embryos, first expressed in neuronal precursor cells during gastrulation (PubMed:20876647). At the comma and 1.5-fold embryonic stage, expressed in neurons in the head, the tail and along the ventral cord (PubMed:20876647). In 1.5-fold stage embryos, expressed in the nerve ring bundle (PubMed:28846083). At the L1 larval stage, expressed in the ventral nerve cord and in a subset of dorsal D-type GABAergic motorneurons (PubMed:22442082, PubMed:23376536). At the L2 larval stage, expressed along the ventral nerve cord (PubMed:23376536). Not expressed in ventral D-type GABAergic motorneurons at the L2 larval stage (PubMed:23376536).
messages: axon
messages: dendrite

6239:CELE T14G10.2
gene id: 6239:CELE_T14G10.2
uniprot id: G5EDB9
uniprot id: G5EEE0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle.
messages: Beginning in the L2 stage, onward, animals display striking and progressive defects in morphology of the epidermis. Worms show molting defect and exhibit a trail of old cuticle that remains attached to the posterior part of the body. Longitudinal ridges termed alae, which are cuticular structures secreted by lateral hypodermal seam cells, are poorly distinct or interrupted. Sensory rays in males are malformed. Developed a fairly normal gonad but have a strongly reduced fertility. Show uncoordinated movement and an enlarged gut lumen. Died as a 'bag of worms', or alternatively, as a result of a burst vulva.
messages: Belongs to the RAPGEF2 family.
messages: Expressed at the comma stage in endodermal precursor and hypodermal cells of the embryo. Expressed in the hypodermis and gut during elongation and larval stages. Expressed in neuronal precursor cells at the comma stage. Expressed in neuronal cells in the head and tail, in cells of the ventral nerve cord and of the pharynx at the L1 hatched larvae stage.
messages: Expressed in hermaphrodite-specific neurons (HSNs), oviduct sheath cells and lateral seam cells.

6239:CELE C15B12.6
gene id: 6239:CELE_C15B12.6
uniprot id: Q18008
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in neurons.
messages: Interacts with the receptor complex composed of ilcr-1 and ilcr-2. Also interacts with pik-1.
messages: May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.

6239:CELE ZK666.8
gene id: 6239:CELE_ZK666.8
uniprot id: Q23566
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE Y71F9B.2
gene id: 6239:CELE_Y71F9B.2
uniprot id: Q9N4G7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
messages: Magnesium. Also active with cobalt or copper.
messages: Mitochondrion inner membrane

6239:CELE F36H1.10
gene id: 6239:CELE_F36H1.10
uniprot id: Q7YTM7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Constitutively expressed. Not regulated by heme level.
messages: Heme transporter.
messages: Membrane

6239:CELE K01D12.13
gene id: 6239:CELE_K01D12.13
uniprot id: G5EBH4
uniprot id: Q21097
names: Similarity
messages: Belongs to the FAX family.

6239:CELE F13G3.2
gene id: 6239:CELE_F13G3.2
uniprot id: Q19419
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C18E9.2
gene id: 6239:CELE_C18E9.2
uniprot id: Q18093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE K10G9.3
gene id: 6239:CELE_K10G9.3
uniprot id: G1K0W1
uniprot id: Q8WR51
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 68 family.
messages: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:15233996, PubMed:26854667). O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombospondin (TSP) and spondin families (By similarity).
messages: Endoplasmic reticulum
messages: Expressed in the anterior part of embryos, in the hypodermal and neuronal cells of the head. Expressed at different levels in a variety of cell types after hatching, including neuronal, hypodermal, muscle, intestinal, and somatic gonadal cells. Expressed in the nerve ring around the pharynx, in dorsal and ventral nerve cords, intestine, and a variety of hypodermal cells of L1-L3 larvae. Expressed in gonadal sheath cells, spermatheca, and tissues surrounding the vulva of adult hermaphrodites, and in the body wall muscle and hypodermal cells of adults of both sexes.
messages: Expressed starts at morphogenetic embryonic stages and continues throughout development.
messages: Golgi apparatus

6239:CELE T22C1.2
gene id: 6239:CELE_T22C1.2
uniprot id: Q22663
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Binds carbon monoxide (CO).
messages: Cell membrane
messages: Cytoplasm
messages: Detected in the head mesodermal cell. In the tail region, detected in the stomatointestinal and anal depressor muscle cells.
messages: Expressed at all developmental stages, but expression relative to adult is decreased in the L3 and dauer stages.
messages: Homodimer. Occurs in an equilibrium of monomeric and dimeric forms in solution.
messages: Nucleus lamina
messages: Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions.
messages: Up-regulated by anoxia but not affected by hypoxia.

6239:CELE W06G6.6
gene id: 6239:CELE_W06G6.6
uniprot id: Q9XU61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F13E9.3
gene id: 6239:CELE_F13E9.3
uniprot id: Q19408
names: Function
messages: May have role in hypoxia response.

6239:CELE ZK632.7
gene id: 6239:CELE_ZK632.7
uniprot id: P34653
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Highly expressed in germ cells.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex (By similarity). Interacts with the GW182 family protein ain-1 (PubMed:22402495).
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. Within the PAN complex, may positively regulate fertility (PubMed:23843623).
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

6239:CELE F58A6.10
gene id: 6239:CELE_F58A6.10
uniprot id: A0A3B1DZW5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm accumulating at the spermathecal-uterine valve 1 hour following mating.
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the head.
messages: G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030).
messages: Perikaryon
messages: dendrite

6239:CELE C38H2.2
gene id: 6239:CELE_C38H2.2
uniprot id: Q18515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: Ubiquitously expressed throughout development. Present in all cells.

6239:CELE T20B12.7
gene id: 6239:CELE_T20B12.7
uniprot id: P41847
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

6239:CELE F36A2.6
gene id: 6239:CELE_F36A2.6
uniprot id: Q9XVP0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Negatively regulates lifespan.

6239:CELE R11G10.1
gene id: 6239:CELE_R11G10.1
uniprot id: G5ECH3
uniprot id: Q95PJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE D2023.3
gene id: 6239:CELE_D2023.3
uniprot id: E0AHC8
uniprot id: P90785
names: Similarity
messages: Belongs to the synaptotagmin family.

6239:CELE T02G5.12
gene id: 6239:CELE_T02G5.12
uniprot id: Q22109
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y110A7A.6
gene id: 6239:CELE_Y110A7A.6
uniprot id: Q95Y85
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

6239:CELE T01D3.1
gene id: 6239:CELE_T01D3.1
uniprot id: H9G306
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W09C2.1
gene id: 6239:CELE_W09C2.1
uniprot id: H9G2S7
uniprot id: P28515
uniprot id: Q3S1J8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Both zinc fingers are required for DNA binding in vitro.
messages: Expressed from the 28 cell stage of embryogenesis in hypodermal and muscle precursor cells (at protein level) (PubMed:9224715). Expressed from the 20-30 cell stage of embryogenesis onwards (PubMed:16303852). At the beginning of the comma stage, expression decreases in the dorsal and ventral hypodermis, but remains high in the seam cells until the pretzel stage of embryogenesis (PubMed:16303852). Expressed in neuronal cells of the retrovesicular ganglion during the threefold stage of embryogenesis (PubMed:16303852). Expressed highly in seam cells and retrovesicular ganglion and ventral cord neuronal cells from the L1 stage of larval development to adult (PubMed:16303852). Expressed in the sperm-producing germ line in spermatogenesis during the L4 stage of larval development (PubMed:19591818).
messages: Expressed in ventral cord and retrovesicular ganglion neurons. Expressed in vulval muscles of hermaphrodites and lateral seam and tail seam cells of males. Expressed in spermatozoa within the spermatheca of hermaphrodites.
messages: Mainly embryonic lethal (PubMed:9224715). Mutants have defective body morphogenesis (PubMed:9224715). Embryos have few or no hypodermal cells, but more neuronal and muscle cells due to defective cell divisions and cell fate specification of ABarp- and ABpla-derived and C blastomere hypodermal precursor cells of the blastomere (PubMed:9224715). Defective alae formation and bursting vulva phenotype at the L4 stage of larval development (PubMed:25816370). RNAi-mediated knockdown results in a reduced brood size, complete or half-sterility and male tail defects (PubMed:19591818). Sterility may be due to sperm infertility and sperm morphological and mobility defects (PubMed:19591818). RNAi-mediated knockdown results in flaccidity, locomotion defects, herniating gonad and gross cuticle abnormalities which may be attributed to seam cell loss, and abnormal tail morphology and reduced tail seam cells in males (PubMed:16303852). Ninety percent of embryos produced by animals fed RNAi for more than 10 hours arrest early in development (PubMed:16303852). Embryos laid 6-10 hours after RNAi administration develop to the L1 stage of larval development, but display a lumpy dumpy phenotype with reduced elt-3 expression in dorsal and ventral hypodermal cells and greatly reduced seam cells with disorganised alignment and abnormal fusion of present seam cells (PubMed:16303852). RNAi-mediated knockdown at the L1, L2 or L3 larval stages results in a general loss of structural integrity 2-4 hours following the L4 larval stage to adult molt transition (PubMed:16303852). RNAi-mediated knockdown in temperature sensitive mutants leads to abnormal dauer formation with the majority of larvae arresting and appearing dauer-like following 30-35 hours after RNAi feeding (PubMed:16303852). Surviving larvae are wider in diameter than wild-type, have reduced motility, no pharyngeal pumping, granular appearance of the hypodermal and gut cytoplasm and dauer-like gonad morphology (PubMed:16303852). 40 and …
messages: Nucleus
messages: Perikaryon
messages: Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof (PubMed:19591818, PubMed:21829390). During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage (PubMed:9224715, PubMed:16303852, PubMed:11259601). The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres (PubMed:9224715). Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion (PubMed:16303852). Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif (PubMed:21829390). Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium (PubMed:21829390). Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells (PubMed:16303852, PubMed:11259601). During postembryonic development, has a role in sperm development (PubMed:19591818, PubMed:29702639). Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression (PubMed:19591818). Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41 (PubMed:25816370).
messages: axon

6239:CELE F29G9.5
gene id: 6239:CELE_F29G9.5
uniprot id: O16368
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown at the L1 larval stage, causes 20 percent increase in mei-1 protein levels.
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1 (PubMed:22621901).

6239:CELE F14D12.6
gene id: 6239:CELE_F14D12.6
uniprot id: Q7JP61
uniprot id: Q7JP62
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C13C12.2
gene id: 6239:CELE_C13C12.2
uniprot id: Q17944
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in early developing glial cells of the embryo and accumulates between the embryo and the eggshell.
messages: Expressed in sheath and socket glial cells in both the amphid and phasmid ciliated sensory neurons (at protein level).
messages: Interacts with daf-6.
messages: Required for the localization of daf-6 to the socket glial channel and the sheath lumen (PubMed:34115759). In association with daf-6, plays a role in dendrite extension and ciliogenesis to ensure the formation of glial channels in amphid and phasmid ciliated sensory neurons (PubMed:34115759).
messages: Secreted

6239:CELE ZK370.5
gene id: 6239:CELE_ZK370.5
uniprot id: Q02332
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity). Required for normal lifespan (PubMed:36173858).
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown increases lifespan.

6239:CELE M176.1
gene id: 6239:CELE_M176.1
uniprot id: Q21550
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C27H6.3
gene id: 6239:CELE_C27H6.3
uniprot id: O17608
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the germline.

6239:CELE K02B12.8
gene id: 6239:CELE_K02B12.8
uniprot id: C6KRL6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed througout the gonad (at protein level) (PubMed:18949042). Expressed in the germline (PubMed:15340062, PubMed:29521627).
messages: High levels of embryonic lethality, but a small proportion of the surviving progeny develop beyond the L3 larval stage (PubMed:15340062, PubMed:18949042, PubMed:29521627). Of the surviving progeny, there is a high incidence of males (him phenotype) (PubMed:18949042, PubMed:29521627). Impaired meiotic recombination with no chiasma formation between homologous chromosome pairs at diplotene and diakinesis (PubMed:15340062). This is most likely due to an absence of crossover recombination (PubMed:15340062). Disrupted rad-51 localization during meiosis, whereby rad-51-positive foci are present in the gonad similarly to wild-type, however unlike in wild-type, they disappear before the end of pachytene (PubMed:15340062).
messages: Interacts with zhp-4; the interaction is required for their localization along paired chromosomes and stability, and for the formation of chiasma during meiotic recombination.
messages: Recruited co-dependently with zhp-4 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:15340062, PubMed:18949042, PubMed:29521627, PubMed:30379819). In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the homolog pair to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1 (PubMed:29521627, PubMed:30379819). This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis (PubMed:29521627, PubMed:30379819). Plays a role in the segregation of homologous chromosomes following the completion of crossovers (PubMed:18949042). Together with him-14 and msh-5 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114).

6239:CELE T13C5.8
gene id: 6239:CELE_T13C5.8
uniprot id: Q8T3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFP1 family.
messages: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
messages: Mitochondrion inner membrane

6239:CELE C44C3.11
gene id: 6239:CELE_C44C3.11
uniprot id: Q7YXG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K04G2.1
gene id: 6239:CELE_K04G2.1
uniprot id: Q21230
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: RNAi-mediated knockdown results in a reduced body length (PubMed:18635357). This phenotype in suppressed in a ced-4 n1162 mutant background (PubMed:18635357).
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).

6239:CELE F47A4.2
gene id: 6239:CELE_F47A4.2
uniprot id: Q20497
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development.
messages: Component of the Mediator complex.
messages: Expressed in vulval precursor cells, the anchor cell and the hyp7 cell at the time of vulval fate specification and throughout vulval development. Expressed from the 8-cell stage of embryogenesis.
messages: Nucleus
messages: Ubiquitously expressed.

6239:CELE Y41G9A.4
gene id: 6239:CELE_Y41G9A.4
uniprot id: A0A0K3ATD8
uniprot id: H2L0Q3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-2.
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity). Along with gbb-2, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679). Acts in neurons to regulate lifespan, and this may be through G-protein-egl-8/PLC-beta signaling to the transcription factor daf-16/FOXO (PubMed:26537867).
messages: Expressed in the nervous system, including cholinergic motor neurons, but not in GABAergic motor neurons or muscle.
messages: Increased lifespan (PubMed:26537867). Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Double knockout with gbb-2 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582).
messages: May form a heterodimer with gbb-2.
messages: Membrane

6239:CELE F02E8.1
gene id: 6239:CELE_F02E8.1
uniprot id: Q19126
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: Expressed in somatic tissues throughout the larval stages and in adults.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the subunits of the catalytic subcomplexes relative to the rotary elements (Probable). Plays a role in somatic development (PubMed:17223323). Does not play a role in germline development (PubMed:17223323).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown results in either embryonic lethality or arrest at the L2 to L3 larval stages (PubMed:17223323). RNAi-mediated knockdown results in a delay in somatic development (PubMed:17223323). RNAi-mediated knockdown does not cause sterility (PubMed:17223323).
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE E03E2.1
gene id: 6239:CELE_E03E2.1
uniprot id: O17329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
messages: Membrane
messages: Microsome membrane

6239:CELE F58A6.6
gene id: 6239:CELE_F58A6.6
uniprot id: Q20961
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the nervous system, in pharyngeal muscle, hermaphrodite vulval muscles and in the male tail (PubMed:28662030). Not expressed in male somatic gonads or sperm (PubMed:28662030).
messages: G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030).
messages: Perikaryon
messages: Reduced brood size, which is in part due to an abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm moving at a reduced velocity, reversing course frequently and accumulating at the spermathecal-uterine valve 1 hour following mating (PubMed:28662030). No visible defects in oogenesis (PubMed:28662030).
messages: dendrite

6239:CELE Y54E10A.14
gene id: 6239:CELE_Y54E10A.14
uniprot id: Q9N3E5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C07A12.4
gene id: 6239:CELE_C07A12.4
uniprot id: Q17770
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Expressed in oscillating waves in hypodermal cells during the 4 larval stages and in adults.
messages: Heterotetramer of two alpha chains and two beta chains. Exist either as a phy-1(2)/pdi-2(2) tetramer, a phy-2(2)/pdi-2(2) tetramer or as a phy-1/phy-2/pdi-2(2) tetramer.
messages: Involved in cuticle formation (PubMed:10805750). May play a role in the unfolded protein response (PubMed:21199936).
messages: RNAi-mediated knockdown causes embryonic lethality characterized by a retraction of the fully elongated embryo, a progressive disorganization of the embryo and a failure to hatch (PubMed:10805750). Also causes increased expression of the unfolded protein response (UPR) marker hsp-4 (PubMed:21199936).

6239:CELE K09A11.4
gene id: 6239:CELE_K09A11.4
uniprot id: Q27507
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE D1053.2
gene id: 6239:CELE_D1053.2
uniprot id: Q18939
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

6239:CELE R10D12.17
gene id: 6239:CELE_R10D12.17
uniprot id: Q7YWV5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y73B6BL.26
gene id: 6239:CELE_Y73B6BL.26
uniprot id: Q9GUF0
uniprot id: V6CJ96
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08H9.7
gene id: 6239:CELE_F08H9.7
uniprot id: Q19230
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C40H1.4
gene id: 6239:CELE_C40H1.4
uniprot id: Q03574
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Could be implicated in synthesis of very long chain fatty acids.
messages: Membrane

6239:CELE D2085.1
gene id: 6239:CELE_D2085.1
uniprot id: Q18990
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity).
messages: Binds 4 magnesium or manganese ions per subunit.
messages: Expressed in the intestine.
messages: Expressed predominantly in gut precursor cells from the 4E embryonic stage until the bean stage. Expression resumes at the L1 larval stage and continues into adulthood.
messages: GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5).
messages: Homohexamer.
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
messages: RNAi-mediated knockdown causes an arrest at the embryonic stage or at the L1 larval stage (PubMed:16828468). The few surviving animals grow more slowly (PubMed:16828468). L1 larvae have incomplete pharyngeal isthmus elongation, 36 percent of which have the pharynx detached from the buccal cavity (PubMed:16828468). In an umps-1 zu456 mutant background embryo, prevents the formation of abnormally enlarged gut granules (PubMed:20148972).
messages: This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP-sugars required for heparan sulfate proteoglycan biosynthesis (PubMed:16828468). Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles (PubMed:16828468).

6239:CELE Y47D3B.7
gene id: 6239:CELE_Y47D3B.7
uniprot id: Q9XX00
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Broadly expressed, including many cells in the head (PubMed:33370778). Expressed in the intestine (PubMed:12530969).
messages: Endoplasmic reticulum membrane
messages: Expression increased by oxygen deprivation (PubMed:19187779). Expression increased by glucose or fructose supplementation (PubMed:19936816, PubMed:29113111). Expression increased by simulated microgravity (PubMed:32448509).
messages: Key transcription factor that regulates expression of genes involved in sterol biosynthesis and lipid homeostasis.
messages: Nucleus
messages: Precursor of the transcription factor form, which is embedded in the endoplasmic reticulum membrane (By similarity). Processing of this form allows release of the transcription factor form that translocates into the nucleus and activates transcription of genes involved in sterol biosynthesis and lipid homeostasis (By similarity).
messages: Processed in the Golgi apparatus, releasing the protein from the membrane.
messages: RNAi-mediated knockdown causes early larval arrest and a pale, skinny appearance; paleness due to absence of dark, lipid-laden fat granules from the intestine (PubMed:12530969, PubMed:19936816). Decrease in body size, delayed growth, fewer eggs laid and 5-6 days after being laid, many eggs hatch inside the body (PubMed:19936816). Exposure to oleic or linoleic acid returns body size almost to normal and also increases number of eggs laid (PubMed:19936816). In normoxic conditions, reduces total fat levels, but has no effect in anoxia (PubMed:19187779). Reduces the increase in body width/length ratio caused by anoxia (PubMed:19187779). Alters fatty-acid composition, including of monomethyl branched-chain fatty acids (mmBCFAs) (PubMed:15340492). Exacerbates induction of reactive oxygen species (ROS) production and decrease in locomotion behavior caused by simulated microgravity (PubMed:32448509). Knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229). Tissue-specific knockdown in any of several different tissues abolishes elevated levels of H3K4me3 modification (PubMed:35140229).
messages: Transcription factor involved in maintaining normal fat levels (PubMed:19187779). Regulates the expression of genes involved in lipid metabolism in response to nutrient availability, such as the fatty-acid desaturases fat-5, fat-6 and fat-7 (PubMed:12530969, PubMed:19936816). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation, acting in concert with transcription factor mxl-3 (PubMed:29113111). Plays a role in synthesis of monomethyl branched-chain fatty acids (mmBCFAs) as well as other very-long-chain fatty acids (PubMed:15340492). Downstream of the cis-Golgi membrane protein eas-1/GOLT1B and the E3 ubiquitin ligase rnf-145/RNF145, plays a role in the regulation of glial size, perhaps by modulating synthesis of long-chain polyunsaturated fatty-acids (LC-PUFA) (PubMed:33370778). Modulates expression of genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAM) (PubMed:22035958). Probably involved in a feedback loop in which decreased levels of SAM lead to increased transcriptional activity of sbp-1, thereby causing lipid accumulation (PubMed:22035958). Involved in the negative regulation of zinc homeostasis (PubMed:28710073). Involved in the response to simulated microgravity, in concert with Mediator complex subunit mdt-15, probably acting in the intestine (PubMed:32448509). Plays a role in transgenerational lipid accumulation in response to a high-fat diet, probably acting by upregulating wdr-5.1 expression to increase the level of trimethylated 'Lys-4' histone H3 (H3K4me3), which may then induce the expression of fat-5, fat-6 and fat-7 (PubMed:35140229). May act as an oxygen sensor for lipid metabolism (PubMed:19187779).
messages: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus.

6239:CELE R13F6.9
gene id: 6239:CELE_R13F6.9
uniprot id: P45896
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Expressed at low levels in the tail tip in both males and hermaphrodites from the L4 larval stage.
messages: Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Nucleus
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype).

6239:CELE C09H10.2
gene id: 6239:CELE_C09H10.2
uniprot id: P48166
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

6239:CELE C17A2.2
gene id: 6239:CELE_C17A2.2
uniprot id: O16536
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y45F10C.2
gene id: 6239:CELE_Y45F10C.2
uniprot id: O45941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UPF0375 family.
messages: Expressed in the uterine epithelium.
messages: Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.
messages: Secreted

6239:CELE F54A3.2
gene id: 6239:CELE_F54A3.2
uniprot id: Q9N4J7
names: Similarity
messages: Belongs to the TOG/XMAP215 family.

6239:CELE F52B11.4
gene id: 6239:CELE_F52B11.4
uniprot id: Q9XUE9
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T22A3.6
gene id: 6239:CELE_T22A3.6
uniprot id: P91823
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F14B8.2
gene id: 6239:CELE_F14B8.2
uniprot id: Q19443
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Defective in RNA-mediated gene silencing.
messages: Late endosome membrane
messages: Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen.
messages: Ubiquitously present in most tissues tested. Expressed in the somatic cells of intestine, muscle, neurons, somatic gonad and embryos but not in the germline (at protein level).

6239:CELE ZK112.1
gene id: 6239:CELE_ZK112.1
uniprot id: P34610
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE F46A9.5
gene id: 6239:CELE_F46A9.5
uniprot id: G5ECU1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the SKP1 family.
messages: Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex containing F-box domain-containing protein sel-10 as the substrate recognition component (PubMed:17626846). Interacts with cul-1 (PubMed:11864567, PubMed:11864566). May interact with the F-box protein mec-15 (PubMed:11864566). Interacts with dre-1 (PubMed:17336909). Interacts with syg-1 (PubMed:17626846). Interacts with sel-10 (PubMed:18718460).
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates cell proliferation during embryonic and larval development (PubMed:11864567, PubMed:11864566). Involved in synapse elimination in early synapse development (PubMed:17626846). May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress (PubMed:18340346). Plays a role in sex determination (PubMed:18718460).
messages: The majority of animals are either embryonic or larval lethal. Rare surviving animals develop into uncoordinated sterile adults with hyperplasia of tissues including the uterus and the spermatheca of the somatic gonad (PubMed:18718460). RNAi-mediated knockdown results in a reduction in brood size of the injected parent and embryonic lethality of offspring between gastrulation and the two-cell phase of embryogenesis (PubMed:11864566). RNAi-mediated knockdown causes synapse clusters that are retained rather than eliminated in the secondary synapse region, anterior to the vulva during synapse development (PubMed:17626846). RNAi-mediated knockdown leads to an increase in germ cell apoptosis in response to genotoxic stress (PubMed:18340346). RNAi-mediated knockdown within 16 hours of RNAi administration results in defects in embryonic divisions including spindle mispositioning, abnormal polar bodies and ectopic furrows, and hyperplasia of the somatic gonad and hypodermis in larvae (PubMed:11864567). All embryos laid 16 hours post RNAi treatment arrest and contain almost twice the number of cells as wild-type embryos (PubMed:11864567). Zygotic RNAi-mediated knockdown results in 90% sterility (PubMed:11864567).
messages: Ubiquitously expressed in the adult.

6239:CELE K03E5.1
gene id: 6239:CELE_K03E5.1
uniprot id: O61849
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F21C3.2
gene id: 6239:CELE_F21C3.2
uniprot id: Q19673
names: Cofactor
names: Similarity
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.

6239:CELE T05A1.5
gene id: 6239:CELE_T05A1.5
uniprot id: Q2XN03
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C01H6.9
gene id: 6239:CELE_C01H6.9
uniprot id: G5EE25
names: Subcellular Location Annotation
messages: Chromosome

6239:CELE F54C8.6
gene id: 6239:CELE_F54C8.6
uniprot id: P34444
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T07A9.3
gene id: 6239:CELE_T07A9.3
uniprot id: O44408
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by mek-1 mediated phosphorylation. No differences in basal activation between larvae and adults (PubMed:22554143). Inhibited by phosphatase vhp-1 (PubMed:15116070).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: By B.thuringiensis pore-forming toxin Cry5B.
messages: Cytoplasm
messages: Expressed in somatic and germline tissues.
messages: Interacts with glh-1, glh-2 (via C-terminus), glh-3 (via C-terminus) and glh-4 (via C-terminus) (PubMed:12435362, PubMed:17699606). Interacts with csn-5; the interaction may prevent glh-1 degradation induced by kgb-1 (PubMed:17699606). Interacts with fos-1 (PubMed:23437011).
messages: May be phosphorylated by mek-1 on Ser-198 and/or Tyr-200 (PubMed:15116070). Phosphorylation is induced upon Cu(2+) and arsenite-mediated cell stimulation and by fasting (PubMed:15116070, PubMed:23352664).
messages: Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:22554143, PubMed:23352664). Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2 (PubMed:23437011). Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1 (PubMed:23352664). Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome (PubMed:17699606). Required for oogenesis and probably also for spermatogenesis (PubMed:12435362). Involved in the response to environmental stress such as heavy metals, infection and protein folding stress in an age-dependent manner (PubMed:15116070, PubMed:22554143). In larvae, has a protective role which becomes detrimental in adults (PubMed:22554143). May control susceptibility to infection, heavy metal stress and premature lethality by regulating daf-16 cellular localization (PubMed:22554143). Involved in the transcriptional response to bacterial pore-forming toxins and to fasting (PubMed:15256590, PubMed:21408619, PubMed:23352664). Required for fasting-induced longevity (PubMed:23352664). Involved in axon regeneration after injury downstream of tyrosine receptor svh-2 (PubMed:21670305, PubMed:22388962).
messages: Temperature-sensitive sterility in both hermaphrodites and males which, in hermaphrodites, is associated with disorganized gonads and with impaired production of endomitotic oocytes, likely due to a defect in oocyte maturation which often results in vulva protrusion (PubMed:12435362). Both hermaphrodites and males produce sperm but it is defective (PubMed:12435362). In addition, the formation of P granules is disrupted in later stage of oogenesis and the protein levels of glh-1, a component of the P granules, are increased (PubMed:12435362, PubMed:17699606). Old adults are bloated and move more slowly (PubMed:17699606). Hypersensitivity and impaired up-regulation of several genes in response to heavy metals (Cu(2+) and Cd(2+)) and to bacterial pore-forming toxins exposure (PubMed:15256590, PubMed:15116070, PubMed:21408619, PubMed:23437011). RNAi knockdown at different developmental stages shows age-dependent defects: larvae are hypersensitive to cadmium and protein folding stress and have a reduced survival capacity but these effects are not observed in adults (PubMed:22554143). Impaired fasting-induced longevity (PubMed:23352664). RNAi knockdown in adults results in increased daf-16 nuclear localization in intestinal cells but not in response to fasting (PubMed:22554143, PubMed:23352664). Mutants have impaired axon regeneration (PubMed:21670305).

6239:CELE C24H12.5
gene id: 6239:CELE_C24H12.5
uniprot id: A0A0K3ARI1
uniprot id: A0A0K3AWU0
uniprot id: H1ZUV7
uniprot id: H2KYF1
uniprot id: Q95X82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

6239:CELE Y47D3A.26
gene id: 6239:CELE_Y47D3A.26
uniprot id: B2FDA8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Chromosome
messages: Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their SMC hinge domain, scc-1 which links them, and scc-3. Interacts with scc-1, smc-1 and tim-1.
messages: Involved in chromosome cohesion during cell cycle and in DNA repair (PubMed:21957461). Involved in the repair of double strand breaks during mitosis and meiosis (PubMed:21957461). Required for chromosome segregation during mitosis (PubMed:12808038). Central component of cohesin complex (PubMed:12827206, PubMed:12808038, PubMed:21957461). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). Required for the localization of lab-1 to meiotic and mitotic chromosomes (PubMed:22927794).
messages: Nucleus
messages: RNAi-mediated knock-down is embryonic lethal and results in aberrant chromosome segregation during mitosis. RNAi-mediated knockdown at 20 degrees Celsius results in the mis-localization of lab-1 in germ line nuclei (PubMed:22927794).

6239:CELE C05E11.1
gene id: 6239:CELE_C05E11.1
uniprot id: Q17667
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Expressed in cell bodies along the ventral cord around the pharynx and the tail both in larvae and adults. Also expressed in muscles and hypodermal cells.
messages: Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1.
messages: Worms exhibit increased resistance to aldicarb indicative of an affect on neurotransmission but equal sensitivity to levamisole which specifically inhibits the postsynapse. Mutants also show mislocalized rab-3 and snb-1 proteins.

6239:CELE T07C12.7
gene id: 6239:CELE_T07C12.7
uniprot id: Q22285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y65B4BR.9
gene id: 6239:CELE_Y65B4BR.9
uniprot id: P56407
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for cell specification of the PVN neuron.

6239:CELE D2045.6
gene id: 6239:CELE_D2045.6
uniprot id: Q17389
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cullin family.
messages: Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641). Interacts with Skp1-related proteins skr-1, skr-2, skr-3, skr-4, skr-7, skr-8, skr-9 and skr-10 (PubMed:11864566).
messages: Cytoplasm
messages: Highest levels in embryos and lower levels in larvae and adults.
messages: Neddylated; which enhances the ubiquitination activity of SCF.
messages: Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
messages: Ubiquitous.

6239:CELE F59E11.11
gene id: 6239:CELE_F59E11.11
uniprot id: O16753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T23H2.5
gene id: 6239:CELE_T23H2.5
uniprot id: Q94148
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Almost ubiquitously expressed. Expressed in intestine, hypodermis, seam cells, body-wall muscles, many neurons, oviduct sheath cell, spermatheca, coelomocytes and pharyngeal and nerve ring.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts (GTP-bound form) with ehbp-1 (via C-terminal coiled coil) (PubMed:20573983, PubMed:22869721). Interacts (GTP-bound form) with cnt-1 (via C-terminal ankyrin repeat) (PubMed:22869721). Interacts (GTP-bound form) with rab-5 GAP, tbc-2 (via putative coiled coil domain) (PubMed:23100538, PubMed:26393361). Interacts (GTP-bound form) with amph-1 (PubMed:26393361).
messages: Intestinal cells exhibit abnormally abundant rab-5 and rab-7 positive enlarged early endosomes, which accumulate basolaterally recycling transmembrane cargo molecules and fluid indicating a block in basolateral transport (PubMed:16394106, PubMed:20573983). On the other hand, rme-1 positive recycling endosomes are missing. No endocytic trafficking defects in oocytes or coelomocytes (PubMed:16394106). Almost complete loss of cnt-1 endosomal localization in the intestinal epithelium. Overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate (PubMed:22869721). Nearly complete loss of basolateral endosomal tubule extensions of the intestine (PubMed:25301900). The endosomal localization of tbc-2 is strongly reduced leading to increased rab-5 association with membranes in the intestinal epithelia (PubMed:26393361). Cholesterol-dependent accumulation of glr-1 in large accretions running along the length of the ventral cord neurite bundle while synapses don't have general formation defects. Animals display a decreased frequency of locomotional reversals and significantly reduced response to nose-touch suggesting reduced glr-1 signaling (PubMed:17761527, PubMed:20573983). Rab-10 lin-10 double mutant displays additive glr-1 trafficking defects indicating that they both regulate endocytic recycling of AMPA receptors to synapses, but most probably along distinct regulatory pathways (PubMed:17761527). Complete loss of dense core vesicles (DCVs) secretion of neuropeptides from DA/DB motoneurons, while synaptic ultrastructure and synaptic vesicles (SV) exocytosis as well as coelomocyte function are unaffected (PubMed:23100538). Severely reduced proximal dendritic arborization in multi-dendritic PVD sensory neurons, but minimal effect on dendritic branching and growth on the distal area of the PVD. The growth of PVD axon is normal. Reduced dendritic growth of the multi-dendritic FLP neurons, but no effect on the dendritic growth of unbranched dendrites of the OLL, AWB and …
messages: Late endosome membrane
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). Tbc-4 is a likely GAP of this rab (PubMed:23100538). Denn-4 is a putative GEF of this rab (PubMed:26633194).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:23100538, PubMed:26394140, PubMed:26633194). Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rme-1 (PubMed:16394106). Involved in the formation of the endosomal tubular network that is required for basolateral recycling of clathrin-independent endocytic cargo such as daf-4 in the intestine (PubMed:25301900). Required for the recruitment of cnt-1 effector to endosomal membranes in the intestinal epithelium, which is important for the regulation of levels of endosomal phosphatidylinositol-4,5-bisphosphate, a key phosphoinositide in membrane traffic, and for the recruitment of endosomal membrane-bending proteins, rme-1 and sdpn-1 (PubMed:22869721). Recruits the rab-5 GTPase-activating protein tbc-2 to endosomes where it then inactivates rab-5 resulting in removal of rab-5 from membranes, which is necessary for cargo transport from early endosomes to recycling endosomes in the basolateral intestine (PubMed:26393361). Regulates recycling of synaptic membrane AMPA glutamate receptor, glr-1, from intracellular endosomal compartments back to synapses in a cholesterol-dependent endocytosis pathway functioning after clathrin-independent endocytosis in command interneurons (PubMed:17761527). Regulates neuropeptide release from dense core vesicles (DCVs) of cholinergic motoneurons in cooperation with rab-5. They reciprocally recruit each other's inactivating GAP molecule leading to local exclusion of one or the other rab protein at the Golgi-endosomal interphase at a…

6239:CELE T07H8.5
gene id: 6239:CELE_T07H8.5
uniprot id: O61892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE D2089.5
gene id: 6239:CELE_D2089.5
uniprot id: Q19000
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

6239:CELE F54C9.4
gene id: 6239:CELE_F54C9.4
uniprot id: Q20754
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Expressed in the hypodermal cells of the tail and head, the seam cells, and in the hyp7 syncytial hypodermis in the mid- to late-larval L4 stage, and young adult (PubMed:24569038, PubMed:29604168). Not expressed in the cells of the developing vulva (PubMed:24569038).
messages: Nucleus
messages: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle (PubMed:24569038).
messages: RNAi-mediated knockdown causes hypodermal or cuticular rupture, typically in the anterior body region (PubMed:24569038). Abnormal gap between the outer layer of hypodermis and muscle and the internal organs, perhaps due to defects in cuticle integrity (PubMed:24569038).

6239:CELE F49E10.3
gene id: 6239:CELE_F49E10.3
uniprot id: G5EEC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Expressed in eggs, all larval stages and in adult (PubMed:9685599). Expressed in the ALA neuron in L4 stage larvae (PubMed:27546573).
messages: Expressed in the ASI sensory neurons, the ALA interneuron and the AVG interneuron from where secretion occurs. Expression in the ASI neurons is necessary and sufficient to maintain serotonin-induced fat loss.
messages: FMRFamide-like neuropeptides (PubMed:16377032, PubMed:28128367). Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss (PubMed:33078707). Together with atfs-1, negatively regulates the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress (PubMed:33078707).
messages: Retention of a significantly greater proportion of body fat compared to wild-type following treatment with serotonin, almost complete suppression of the transcriptional induction of the atgl-1 lipase, reduced egg-laying and suppression of octopamine-induced fat loss. No effect on serotonin-induced food intake, reproduction or the enhanced slowing response which is a satiety-like locomotor response to food availability.
messages: SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro.
messages: Secreted
messages: TPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro.

6239:CELE C34F11.3
gene id: 6239:CELE_C34F11.3
uniprot id: D7SFL2
uniprot id: H2KZ18
uniprot id: H2KZ19
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

6239:CELE CD4.6
gene id: 6239:CELE_CD4.6
uniprot id: O44156
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE K11D9.2
gene id: 6239:CELE_K11D9.2
uniprot id: A8WI68
uniprot id: G5EEK8
uniprot id: Q9XU13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

6239:CELE F18C5.2
gene id: 6239:CELE_F18C5.2
uniprot id: Q19546
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
messages: Nucleus

6239:CELE C49A1.2
gene id: 6239:CELE_C49A1.2
uniprot id: A0A131MB99
uniprot id: A0A131MBH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F57H12.7
gene id: 6239:CELE_F57H12.7
uniprot id: O45100
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Expressed in touch receptors from late embryos to adults.
messages: Expressed solely in touch receptor neurons.
messages: Mutants are partially insensitive to body touch.
messages: Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.

6239:CELE W04C9.2
gene id: 6239:CELE_W04C9.2
uniprot id: Q9TZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE T10D4.13
gene id: 6239:CELE_T10D4.13
uniprot id: Q71UE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE Y38C9A.2
gene id: 6239:CELE_Y38C9A.2
uniprot id: Q18905
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.

6239:CELE F13B10.2
gene id: 6239:CELE_F13B10.2
uniprot id: G5ECE5
uniprot id: G5EEC0
uniprot id: P50880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Cytoplasm
messages: The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

6239:CELE B0361.6
gene id: 6239:CELE_B0361.6
uniprot id: Q10950
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

6239:CELE F08G2.1
gene id: 6239:CELE_F08G2.1
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE K04F10.1
gene id: 6239:CELE_K04F10.1
uniprot id: O44771
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C51E3.6
gene id: 6239:CELE_C51E3.6
uniprot id: Q18771
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y5F2A.2
gene id: 6239:CELE_Y5F2A.2
uniprot id: Q9XWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F07C6.1
gene id: 6239:CELE_F07C6.1
uniprot id: Q19157
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in neurons and intestine.
messages: Nucleus

6239:CELE Y39G10AR.10
gene id: 6239:CELE_Y39G10AR.10
uniprot id: Q95XR4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Aggregates of epg-2 peak in abundance at the 100 cell stage then decrease until they are very few at the comma stage (PubMed:20550938, PubMed:28806108). Absent from the 200 stage onwards (PubMed:24140420, PubMed:28806108).
messages: Cytoplasm
messages: Interacts with sepa-1 (PubMed:24140420, PubMed:28806108). Interacts (via the LIR motifs) with lgg-1 and lgg-2 (PubMed:26687600). Shows strong interaction with lgg-1 and weak interaction with lgg-2 (PubMed:26687600).
messages: Involved in autophagy (PubMed:20550938, PubMed:24140420, PubMed:24374177). Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1 (PubMed:20550938). Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells (PubMed:24140420, PubMed:28806108). This ensures exclusive localization of the P-granules in germ cells (PubMed:24140420, PubMed:28806108). May also play a role in the removal of sepa-1 from somatic cells (PubMed:28806108).
messages: No colocalization of P-granule components with lgg-1 (PubMed:20550938). Furthermore, there is an accumulation of pgl-3 positive P-granules in somatic cells of embryos (PubMed:28806108). RNAi-mediated knockdown results in increased lgg-2-positive autophagosomes following fertilization and at later embryonic stages (PubMed:24374177).
messages: The LIR motifs (LC3-interacting region) are required for its interaction with lgg-1 and lgg-2.

6239:CELE F20D6.9
gene id: 6239:CELE_F20D6.9
uniprot id: Q19649
names: Similarity
messages: Belongs to the histone H3 family.

6239:CELE W05H5.6
gene id: 6239:CELE_W05H5.6
uniprot id: O18175
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F53F1.10
gene id: 6239:CELE_F53F1.10
uniprot id: P92001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C17G10.5
gene id: 6239:CELE_C17G10.5
uniprot id: Q09975
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE F56H6.1
gene id: 6239:CELE_F56H6.1
uniprot id: O45579
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47H9A.1
gene id: 6239:CELE_Y47H9A.1
uniprot id: G5EFH6
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE Y50D7A.6
gene id: 6239:CELE_Y50D7A.6
uniprot id: Q965T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
messages: Component of the kinesin II motor complex (composed of kap-1 and the heterodimeric motor proteins klp-11 and klp-20) which is required for intraflagellar transport (IFT) (PubMed:20833139, PubMed:20498083). Heterodimerizes with klp-11 to form a 'processive' molecular motor upon IFT cargo binding, which, within the kinesin II motor complex, binds to and moves along microtubules in a unidirectional manner (without dissociation of the heterodimer), and in turn, is responsible for the IFT of cargo (PubMed:20498083). Specifically, the kinesin II motor complex, together with the kinesin motor protein osm-3 moves along microtubules and is required for anterograde IFT along the middle segment of the sensory neuron cilia (PubMed:17000880, PubMed:20833139, PubMed:28479320). In particular, the kinesin II motor complex delivers specific ciliary cargo proteins such as che-3 which are related to motility to ciliary tips (PubMed:28479320). This is likely mediated by IFT complexes A and B (PubMed:28479320).
messages: Component of the kinesin II motor complex, a heterotrimeric complex composed of kap-1, klp-11 and klp-20 (PubMed:17000880, PubMed:20833139, PubMed:20498083, PubMed:28479320). Interacts (via C-terminus) with klp-11 (via C-terminus) to form a heterodimer (PubMed:20498083, PubMed:21917588). Furthermore, within the heterodimer, the C-termini of klp-20 and klp-11 interact to form a coiled coil (stalk) or tail domain, and this is necessary for association with kap-1, and kinesin II motor complex activity upon IFT cargo binding (PubMed:20498083, PubMed:21917588). Prior to cargo binding, the klp-11/klp-20 heterodimer is autoinhibited by the tail domain of the heterodimer, which folds onto the kinesin motor domain (PubMed:20498083). Cargo binding to the heterodimer relieves the autoinhibition, and allows for an extended conformation of the tail domain, and function of the heterodimer (PubMed:20498083).
messages: cilium
messages: cytoskeleton

6239:CELE M01G12.12
gene id: 6239:CELE_M01G12.12
uniprot id: G5EFA8
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE T23F11.5
gene id: 6239:CELE_T23F11.5
uniprot id: P46567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE K04G11.5
gene id: 6239:CELE_K04G11.5
uniprot id: A0A1C3NSL2
uniprot id: A0A1C3NSP8
uniprot id: A0A1C3NSR4
uniprot id: A0A1C3NSS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

6239:CELE B0303.15
gene id: 6239:CELE_B0303.15
uniprot id: P34264
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE F58F9.7
gene id: 6239:CELE_F58F9.7
uniprot id: Q20992
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acyl-CoA oxidase family.
messages: Expressed in intestine.
messages: Homodimer.
messages: In contrast to other acyl-coenzyme A oxidases which bind to and are activated by ATP, does not bind ATP.
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:29863473). Specifically, shortens indol-3-carbonyl(IC)-ascarosides with 7-carbon (IC-asc-C7) or 9-carbon (IC-asc-C9) side chains and contributes to the shortening of ascarosides with 13-carbon (asc-C13) and 15-carbon (asc-C15) side chains (PubMed:29863473).
messages: Peroxisome

6239:CELE F21H7.5
gene id: 6239:CELE_F21H7.5
uniprot id: O45386
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y39B6A.19
gene id: 6239:CELE_Y39B6A.19
uniprot id: B2FDA9
uniprot id: Q9NEV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F14F3.3
gene id: 6239:CELE_F14F3.3
uniprot id: Q19468
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acyl-sn-glycero-3-phosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Involved in the selective incorporation of arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA) and (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA (EPA-CoA) into PI (PubMed:18094042). Besides its role in biomembranes, PI is a precursor of PI 3-phosphate (PIP3) and its fatty acid composition has an important role in PI3P signaling (PubMed:22862955).
messages: Belongs to the membrane-bound acyltransferase family.
messages: Expressed ubiquitously throughout development from early embryo to larval and adult stages. In adults, strongly expressed in pharyngeal muscle, body wall muscle, vulval cells, distal tip cells, intestinal cells and spermatheca.
messages: Membrane
messages: Mutants show larval arrest at an early developmental stage and egg-laying defects; 14% of mutants accumulate unlaid eggs that hatched internally.

6239:CELE F58B3.2
gene id: 6239:CELE_F58B3.2
uniprot id: Q20967
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: Induced by Gram-positive bacterium S.aureus infection (PubMed:24882217). Down-regulated by exposure to Gram-positive bacterium B.thuringiensis spore toxins (PubMed:21931778).
messages: Lacks conserved active site residues, suggesting it has no catalytic activity.
messages: Plays a role in resistance to Gram-positive bacteria S.aureus or B.thuringiensis infection.
messages: Reduced survival in response to bacterium B.thuringiensis infection (PubMed:21931778). Simultaneous RNAi-mediated knockdown of ilys-2 results in a reduction in survival following bacterium S.aureus infection.

6239:CELE R151.9
gene id: 6239:CELE_R151.9
uniprot id: Q21993
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE ZK1010.1
gene id: 6239:CELE_ZK1010.1
uniprot id: P49632
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: For a better understanding, features related to ubiquitin are only indicated for the first chain.
messages: In C.elegans ubiquitin is encoded by 2 different genes. ubq-2 gene codes for a single copy of ubiquitin fused to the ribosomal protein eL40. ubq-1 gene codes for a polyubiquitin precursor with exact head to tail repeats.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit.

6239:CELE Y39A3B.4
gene id: 6239:CELE_Y39A3B.4
uniprot id: Q9N519
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y54G11A.4
gene id: 6239:CELE_Y54G11A.4
uniprot id: Q9XW02
names: Similarity
messages: Belongs to the TTC38 family.

6239:CELE T12D8.7
gene id: 6239:CELE_T12D8.7
uniprot id: O45784
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed from the 4-cell stage through late gastrulation (at protein level) (PubMed:11566890). May be maternally expressed (PubMed:11566890).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890). Abolishes expression of taf-10, perhaps as a result of altered protein stability (PubMed:11566890). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-9 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex (PubMed:11566890).
messages: Throughout PMID:11566890, the gene name taf-10 is used instead of taf-9, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE Y64G10A.8
gene id: 6239:CELE_Y64G10A.8
uniprot id: Q7YWP3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T25E12.10
gene id: 6239:CELE_T25E12.10
uniprot id: O45824
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed from threefold embryo stage, in the nervous system and intestine, and persists through adulthood (PubMed:18434533). Expressed in head neurons of embryos and adults (PubMed:18434533).
messages: Expressed in ventral cord motor neurons and PLM touch neurons.
messages: Involved in negative modulation of unc-40-mediated axon outgrowth (PubMed:18434533). Required for proper presynaptic development in axons that have reached their targets (PubMed:18434533). May function in concert with E3 ubiquitin-protein ligase rpm-1 in regulating axon outgrowth (PubMed:18434533).
messages: Membrane
messages: Suppresses motor neuron dorsal guidance defects in an unc-6 mutant background (PubMed:18434533). Mild shorter and stouter phenotype (PubMed:18434533).

6239:CELE F14F8.6
gene id: 6239:CELE_F14F8.6
uniprot id: Q9XU32
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y40B1A.4
gene id: 6239:CELE_Y40B1A.4
uniprot id: Q9XW26
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Expressed ubiquitously in embryos and early larval animals (PubMed:23851392). Expressed in MSpaa in embryos and in the pharyngeal M4 motorneuron at the first larval stage; expression in the M4 neuron and g1A cells decreases during larval development (PubMed:23851392). Strongly expressed in the seam cells and the hyp7 cells (PubMed:23851392).
messages: Nucleus
messages: RNAi-mediated knockdown causes defects in cell fate, embryonic morphogenesis, and embryonic and larval lethality (PubMed:21884786, PubMed:23851392). Defects in gastrulation; failure of endodermal E cells to internalize at the 26- to 28-cell stage (PubMed:26434722). Reduces cell cycle lengths significantly in endodermal E cells (PubMed:26434722). Significant reduction in expression of end-1 and end-3, and enhances the disruption of intestinal development in an end-3 mutant background (PubMed:26434722). Reduces number of offspring, and the production of oocytes is compromised (PubMed:21884786). Failure of cell death in pharyngeal M4 motor neuron sister (PubMed:21884786).
messages: Transcription factor (PubMed:21884786, PubMed:23851392). Binds to GC-rich DNA motifs, such as 5'-GGGCGGGG-3' (PubMed:21884786, PubMed:23851392). Involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, by transcriptionally activating target genes, such as cell death activator egl-1 and leucine zipper kinase pig-1, in caspase-dependent and -independent apoptotic pathways (PubMed:23851392). Plays a role in the regulation of apoptosis, cell lineage, cell differentiation, embryonic morphogenesis, vulval development, and oocyte production (PubMed:21884786, PubMed:23851392, PubMed:26434722).

6239:CELE C32A3.2
gene id: 6239:CELE_C32A3.2
uniprot id: Q09261
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE Y47D7A.16
gene id: 6239:CELE_Y47D7A.16
uniprot id: Q3LFN0
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activity is strongly inhibited by riboflavin analogs, such as lumiflavin and lumichrome.
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Down-regulated by high levels of riboflavin.
messages: Expressed in intestine.
messages: Highly expressed at L1 larval stage and to a lesser extent in adults.
messages: RNAi-mediated knockdown causes a severe reduction in the number of laid eggs; the few laid eggs fail to hatch.
messages: Riboflavin transporter. Riboflavin transport is Na(+)-independent but pH-sensitive.

6239:CELE H34C03.2
gene id: 6239:CELE_H34C03.2
uniprot id: Q9TYY8
uniprot id: V6CJY2
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE F36G9.3
gene id: 6239:CELE_F36G9.3
uniprot id: K8ESE6
uniprot id: Q9XV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE ZK1127.4
gene id: 6239:CELE_ZK1127.4
uniprot id: Q23402
names: Similarity
messages: Belongs to the BCP1 family.

6239:CELE C54G10.4
gene id: 6239:CELE_C54G10.4
uniprot id: M1ZJU4
uniprot id: Q8I4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE T24H10.1
gene id: 6239:CELE_T24H10.1
uniprot id: P52652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity).
messages: Nucleus

6239:CELE ZK54.1
gene id: 6239:CELE_ZK54.1
uniprot id: Q23514
uniprot id: Q2PJ91
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK938.11
gene id: 6239:CELE_ZK938.11
uniprot id: A0A1C3NSJ4
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE B0511.4
gene id: 6239:CELE_B0511.4
uniprot id: O61821
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C11H1.4
gene id: 6239:CELE_C11H1.4
uniprot id: G5ED99
names: Subcellular Location Annotation
messages: cytosol

6239:CELE K06H7.8
gene id: 6239:CELE_K06H7.8
uniprot id: P34516
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

6239:CELE T24A11.3
gene id: 6239:CELE_T24A11.3
uniprot id: Q22710
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE M01E5.6
gene id: 6239:CELE_M01E5.6
uniprot id: G5EC37
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that connects P-granules in somatic cells with the autophagic machinery (PubMed:19377305, PubMed:19372764, PubMed:19167332, PubMed:24140420). Association with other adapters such as epg-2 and P-granule components such as pgl-3 is required for the accumulation and degradation of P-granules by autophagy in somatic cells (PubMed:19372764, PubMed:19167332, PubMed:24140420, PubMed:28806108). This ensures exclusive localization of the P-granules in germ cells (PubMed:19372764, PubMed:19167332, PubMed:24140420, PubMed:28806108).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Degraded by autophagy.
messages: First expressed in 16-cell stage embryos (PubMed:19167332). Temporal expression during embryogenesis with high expression as embryos develop into 100-stage embryos, but with low expression in most cells at the comma stage and almost diminished expression at the 2-fold stage of embryogenesis (PubMed:19377305, PubMed:19167332, PubMed:21802374, PubMed:24140420). Expressed in the head, tail and intestine, especially in the anterior and posterior intestinal cells, of larvae (PubMed:19167332).
messages: Nucleus
messages: RNAi-mediated knockdown results in the accumulation of cytoplasmic aggregates containing the P-granule component pgl-3 (PubMed:24140420). RNAi-mediated knockdown results in the disrupted formation of P-granules in an atg-18 autophagy mutant background (PubMed:19167332).
messages: Self-associates (PubMed:19167332). Interacts (via the LIR motifs) with lgg-1; the interaction is direct (PubMed:19167332, PubMed:26687600). Interacts (via the LIR motifs) with lgg-2; the interaction is direct (PubMed:26687600). Interacts with pgl-3; interaction is enhanced in the presence of RNA (PubMed:19167332, PubMed:24140420). Interacts with epg-2; may be modulated by prmt-1 (PubMed:24140420, PubMed:28806108).
messages: The LIR motifs (LC3-interacting region) are required for its interaction with lgg-1 and lgg-2.

6239:CELE F46H5.7
gene id: 6239:CELE_F46H5.7
uniprot id: H2L048
uniprot id: Q8MQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
messages: Nucleus

6239:CELE R13A1.9
gene id: 6239:CELE_R13A1.9
uniprot id: Q7YXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE R107.7
gene id: 6239:CELE_R107.7
uniprot id: P10299
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Pi family.
messages: By manganese.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).
messages: Expressed in dopaminergic (DA) neuron (at protein levels).
messages: Homodimer.
messages: RNAi-mediated knockdown causes an increase in Mn(2+)-mediated dopaminergic CEP neuron degeneration.

6239:CELE ZC513.5
gene id: 6239:CELE_ZC513.5
uniprot id: Q23361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane

6239:CELE C41G6.15
gene id: 6239:CELE_C41G6.15
uniprot id: Q9U3M3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T14B4.9
gene id: 6239:CELE_T14B4.9
uniprot id: Q22481
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C05G5.4
gene id: 6239:CELE_C05G5.4
uniprot id: P53596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

6239:CELE T05B4.13
gene id: 6239:CELE_T05B4.13
uniprot id: O16422
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F44E5.5
gene id: 6239:CELE_F44E5.5
uniprot id: G5ECU5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE F40E10.2
gene id: 6239:CELE_F40E10.2
uniprot id: Q20201
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in several differentiated postmitotic neurons during embryogenesis, but not in neuroblasts (PubMed:26153233). Expressed in larvae and adults in sensory neurons ASK and OLQ, the SMB motor neurons, and the SAA neurons (PubMed:26153233).
messages: Expression of immunoglobulin superfamily adhesion molecules rig-5 and lad-2 is abolished in the dorsal and ventral SAA neurons, while expression of the neuropeptide flp-7 gene is lost in the dorsal SAA subtype but remains unaffected in the ventral SAA subtype (PubMed:26153233). No effect on the number of rab-3 expressing neurons on a sox-2 mutant background (PubMed:26153233).
messages: Nucleus
messages: Probable transcription factor (PubMed:26153233). Involved in the terminal differentiation of some neuronal cell types (PubMed:26153233). Dispensable for neuronal fate commitment during embryogenesis (PubMed:26153233).

6239:CELE F35G12.2
gene id: 6239:CELE_F35G12.2
uniprot id: Q20049
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Mitochondrion

6239:CELE B0213.5
gene id: 6239:CELE_B0213.5
uniprot id: O44663
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: Expressed in hypoderm.
messages: May have antimicrobial activity. May play a role in response to fungal infection.
messages: Secreted
messages: Upon D.coniospora infection.

6239:CELE F40B5.2
gene id: 6239:CELE_F40B5.2
uniprot id: Q09320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. LOC643853 family.
messages: Membrane

6239:CELE T24H10.7
gene id: 6239:CELE_T24H10.7
uniprot id: G5ECU7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. Jun subfamily.
messages: Expressed in all cells of the developing spermatheca and in the spermatheca-uterine junction core cells at larval stage L4.
messages: Heterodimer; with fos-1.
messages: Isoform a, isoform b, isoform c and isoform d are expressed in the spermatheca (PubMed:19570917, PubMed:24178943).
messages: Nucleus
messages: Sixty percent of animals display an egg laying defective phenotype. Animals display numerous defects in the reproductive system and have a reduced brood size.
messages: Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3' (PubMed:17942488). Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917).

6239:CELE F11G11.9
gene id: 6239:CELE_F11G11.9
uniprot id: P91247
names: Domain
names: Induction
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue.
messages: Expression increased by knockdown of mpst-1.

6239:KEF34 p09
gene id: 6239:KEF34_p09
uniprot id: G5EFS7
uniprot id: P24888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE F36D4.5
gene id: 6239:CELE_F36D4.5
uniprot id: H2KZK4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Expressed in the pharynx, hypodermis, intestine, head neuron and tail neuron.
messages: Nucleus
messages: Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234).
messages: Worms lacking both POST and ubql-1 have a shorter lifespan and display an accumulation of ubiquitinated proteins in the nucleus.

6239:CELE T22H9.2
gene id: 6239:CELE_T22H9.2
uniprot id: Q9TXN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

6239:CELE C55B7.12
gene id: 6239:CELE_C55B7.12
uniprot id: Q966L8
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in ASE chemosensory neurons and in some other neurons.
messages: Nucleus
messages: Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36.

6239:CELE F38B6.5
gene id: 6239:CELE_F38B6.5
uniprot id: Q20142
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F49E12.5
gene id: 6239:CELE_F49E12.5
uniprot id: Q20618
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein sra family.
messages: Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit.
messages: Expressed in the AWA and AWC chemosensory neurons.
messages: Membrane

6239:CELE Y40B10A.8
gene id: 6239:CELE_Y40B10A.8
uniprot id: Q965W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C52E4.4
gene id: 6239:CELE_C52E4.4
uniprot id: Q18787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

6239:CELE ZC168.6
gene id: 6239:CELE_ZC168.6
uniprot id: Q23246
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE B0244.6
gene id: 6239:CELE_B0244.6
uniprot id: Q09965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. B0244 subfamily.
messages: Cell membrane

6239:CELE K01A2.2
gene id: 6239:CELE_K01A2.2
uniprot id: H2KY95
uniprot id: Q9TZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE B0280.4
gene id: 6239:CELE_B0280.4
uniprot id: P41995
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Expressed in the gut during embryogenesis (PubMed:14648222, Ref.3). Expressed in presumptive intestinal cells and in unidentified cells in the head prior to embryonic elongation (PubMed:14648222). Highly expressed in the most anterior intestinal cell from 1.25-fold stage to 2.5-fold stage (elongating) embryos, but weakly expressed in the remaining intestine in embryos at the 1.25-fold stage (PubMed:14648222). Expressed in additional unidentified cells in the head in 2-fold stage embryos (PubMed:14648222).
messages: May function as transcription regulator (Probable). Essential for larval development (PubMed:14648222, Ref.3). Required for morphogenesis and function of the digestive tract (PubMed:14648222).
messages: Nucleus
messages: RNAi-mediated knockdown results in defects in feeding, and failed growth and development eventually leading to lethality at the larval stage of development. Morphological and functional defects around the pharyngeal intestinal valve and intestine boundary with multiple cavities surrounding the isthmus of the pharynx in 1 to 2 day old larvae, and accumulation of ingested bacteria in the anterior intestine.

6239:CELE F25D1.1
gene id: 6239:CELE_F25D1.1
uniprot id: Q19775
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Approximately 15 percent of mutants have an overextension of the axon of ALM neurons which terminates with a small hook. Approximately 30 percent of mutants have an overextension of the axon of PLM neurons. Approximately 10 percent of mutants lack synaptic branch extension in PLM neurons.
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Expressed in neurons of the nerve ring and motor neurons of the ventral nerve cord.
messages: Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3.
messages: Synapse

6239:CELE W07G1.5
gene id: 6239:CELE_W07G1.5
uniprot id: Q69Z08
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme
messages: cilium membrane
messages: cytoskeleton

6239:CELE F25C8.3
gene id: 6239:CELE_F25C8.3
uniprot id: Q9XV66
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the unc-80 family.
messages: Expressed in the nervous system. Expressed in both acetylcholine and GABA motor neurons.
messages: Fainters phenotype, characterized by defects in locomotion, vesicle depletion, and electrophysiological defects in synaptojanin mutants.
messages: Membrane
messages: Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.

6239:CELE T07F8.3
gene id: 6239:CELE_T07F8.3
uniprot id: Q95ZK7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed both maternally and zygotically throughout development and in adult hermaphrodites and males (at protein level).
messages: Expressed in the germline (at protein level). In adult hermaphrodites, first detected in the transition zone (TZ), weakly expressed in the early mitotic region and in pachytene germ cells, and becomes more abundantly expressed as germ cells enter diakinesis (at protein level). Expressed in primary spermatocytes, but not in secondary spermatocytes or adult sperm (at protein level).
messages: Interacts (via its KH1 domain) with gld-2. Isoform A but not isoform B interacts specifically with fbf-1 and fbf-2 in an RNA-independent manner. Isoform A interacts with gls-1 isoform C.
messages: Loss of both maternal and zygotic expression causes variable lethality, ranging from arrest during embryonic development to soon after hatching, and sterility due to early germline defects. In these animals the germline precursor cells Z2 and Z3 are smaller, divide more slowly and their descendants remain small and indistinct compared to their wild-type counterparts. In addition, some of these animals show somatic defects, including a protruding vulva, multiple vulvae or a reduction in animal size. In zygotic mutant adult hermaphrodites, most spermatogenic cells are blocked as primary spermatocytes, the number of spermatocytes appears lower than normal and spermatogenesis is delayed by several hours. Zygotic mutant homozygous adult males produce some spermatogenic cells, although these sperm are less well defined morphologically than normal. In addition, loss of maternal and zygotic expression results in adult males that produce enlarged granular cells that appear oocyte-like and show chromosomal bivalents typical of oocytes. In zygotic mutants the mitotic region is longer and has more nuclei than normal, the mitotic region/TZ boundary is shifted from 20 to an average of 27 or 28 nuclei and the boundaries between mitotic region and TZ and TZ and pachytene region are not sharp as in wild-type. RNAi-mediated knockdown leads to a shorter polyadenylation tail in neg-1 mRNA in embryos (PubMed:26096734).
messages: Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis. Required for polyadenylation of neg-1 mRNA during embryogenesis (PubMed:26096734).
messages: The deletion mutant gld-3 (q730) makes no detectable GLD-3; it is predicted to generate an mRNA with a premature stop codon, which should be subject to NMD. The deletion mutant gld-3 (q741) removes the fbf-binding site from isoform A, but leaves the gld-2-binding site intact. Animals homozygous for gld-3 (7q41) enter meiosis, but are feminized. In addition, gld-3 protein that retains its gld-2-binding region, does not have the dramatic mitosis/meiosis delay seen in gld-3 null mutants. By contrast, sex determination was not normal; gld-3 (q741) males produced oocytes. Therefore, promotes meiosis primarily via its interaction with gld-2 whereas the sperm/oocyte decision relies on its interaction with fbf.
messages: perinuclear region

6239:CELE Y63D3A.6
gene id: 6239:CELE_Y63D3A.6
uniprot id: Q9U1W0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y71D11A.3
gene id: 6239:CELE_Y71D11A.3
uniprot id: Q8T8B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).
messages: Monomer.

6239:CELE C41C4.7
gene id: 6239:CELE_C41C4.7
uniprot id: Q09500
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells (PubMed:18351800).
messages: Lysosome membrane
messages: phagosome

6239:CELE C34D4.2
gene id: 6239:CELE_C34D4.2
uniprot id: Q27475
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE B0250.1
gene id: 6239:CELE_B0250.1
uniprot id: Q9XVF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Cytoplasm

6239:CELE Y37E11AL.7
gene id: 6239:CELE_Y37E11AL.7
uniprot id: Q965Y1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

6239:CELE R06B10.4
gene id: 6239:CELE_R06B10.4
uniprot id: G5EE02
uniprot id: Q8I6Y9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C41C4.4
gene id: 6239:CELE_C41C4.4
uniprot id: Q09499
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated mainly on serine residues.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Endoplasmic reticulum membrane
messages: In combination with RNAi-mediated knockdown of atf-6, causes sluggish movement, arrested development at the L2 larval stage, and lethality soon thereafter; larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). In combination with RNAi-mediated knockdown of pek-1, larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). RNAi-mediated knockdown restores fertility, reduces the accumulation of unspliced tra-2 in the cytoplasm and suppresses germ line masculinization caused by RNAi-mediated knockdown of rnp-4/RBM8A (PubMed:23149939).
messages: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:11779465). The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes (PubMed:11779465). Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis (PubMed:11779465, PubMed:16184190). Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 and many other genes, upon ER stress (PubMed:18216284, PubMed:16184190). By activating the UPR pathway during non-lethal hypoxia pre-conditioning, confers adaptive protection to subsequent exposure to hypoxia (PubMed:20733002). ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival (PubMed:11779465, PubMed:16184190). Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939).
messages: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity).

6239:CELE Y52B11A.9
gene id: 6239:CELE_Y52B11A.9
uniprot id: Q9XWF2
names: Similarity
messages: Belongs to the KIN17 family.

6239:CELE R05G6.4
gene id: 6239:CELE_R05G6.4
uniprot id: Q21755
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
messages: Nucleus

6239:CELE Y71F9AM.6
gene id: 6239:CELE_Y71F9AM.6
uniprot id: Q95XT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

6239:CELE Y41D4A.6
gene id: 6239:CELE_Y41D4A.6
uniprot id: Q95Y25
uniprot id: U4PC78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

6239:CELE K10H10.2
gene id: 6239:CELE_K10H10.2
uniprot id: O45679
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: By hydrogen sulfide or cyanide (PubMed:21840852). By morpholin-4-ium 4-methoxyphenyl (morpholino) phosphinodithioate (GYY4137) (PubMed:24260346).
messages: Homodimer.
messages: Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O-acetylserine and hydrogen sulfide (PubMed:24100226). By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection (PubMed:21840852). Involved in fertility, growth and aging (PubMed:24260346). Does not mediate survival in high levels of hydrogen sulfide (PubMed:21840852).

6239:CELE Y113G7A.11
gene id: 6239:CELE_Y113G7A.11
uniprot id: Q9U2Z2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Expressed in ASJ amphid sensory neurons.
messages: Expressed throughout development, but higher expression in both embryo and adult stages (at protein level) (PubMed:16567400). Expression increases at the dauer larval stage, compared to the level in the embryo (PubMed:16567400).
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of xenobiotics that contain phenol functional groups (PubMed:16567400, PubMed:16973616). Acts in ASJ sensory neurons to modulate developmental arrest, perhaps by modifying endocrine signaling via the orphan nuclear receptor nhr-1 (PubMed:30514845).
messages: cytosol

6239:CELE ZK520.5
gene id: 6239:CELE_ZK520.5
uniprot id: P52010
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE B0205.8
gene id: 6239:CELE_B0205.8
uniprot id: O61743
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

6239:CELE C50F7.4
gene id: 6239:CELE_C50F7.4
uniprot id: P53589
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

6239:CELE R13D11.8
gene id: 6239:CELE_R13D11.8
uniprot id: O17013
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F25G6.5
gene id: 6239:CELE_F25G6.5
uniprot id: O16925
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

6239:CELE C36C5.11
gene id: 6239:CELE_C36C5.11
uniprot id: A0A0S4XR90
uniprot id: O16404
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y73F4A.1
gene id: 6239:CELE_Y73F4A.1
uniprot id: Q9XWC2
names: Subcellular Location Annotation
messages: Secreted

6239:CELE ZK637.1
gene id: 6239:CELE_ZK637.1
uniprot id: P30638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

6239:CELE F08H9.3
gene id: 6239:CELE_F08H9.3
uniprot id: Q19227
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE C33G8.12
gene id: 6239:CELE_C33G8.12
uniprot id: Q18392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE H03A11.2
gene id: 6239:CELE_H03A11.2
uniprot id: G5EFE3
names: Similarity
messages: Belongs to the FAM154 family.

6239:CELE ZK353.9
gene id: 6239:CELE_ZK353.9
uniprot id: Q95ZI6
names: Similarity
messages: Belongs to the PITHD1 family.

6239:CELE Y41E3.10
gene id: 6239:CELE_Y41E3.10
uniprot id: Q9U2H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

6239:CELE T28F3.9
gene id: 6239:CELE_T28F3.9
uniprot id: G5EBQ5
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C07G1.4
gene id: 6239:CELE_C07G1.4
uniprot id: Q17795
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F58E10.3
gene id: 6239:CELE_F58E10.3
uniprot id: Q9XUW5
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE F23F1.9
gene id: 6239:CELE_F23F1.9
uniprot id: Q95X83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

6239:CELE C25E10.12
gene id: 6239:CELE_C25E10.12
uniprot id: Q18161
names: Similarity
messages: Belongs to the UPF0046 family.

6239:CELE F01D5.2
gene id: 6239:CELE_F01D5.2
uniprot id: Q9XVB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C18A3.4
gene id: 6239:CELE_C18A3.4
uniprot id: Q18071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Probable transporter.

6239:CELE F14F8.11
gene id: 6239:CELE_F14F8.11
uniprot id: Q7YTN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE E04A4.8
gene id: 6239:CELE_E04A4.8
uniprot id: O44480
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

6239:CELE T22B7.1
gene id: 6239:CELE_T22B7.1
uniprot id: Q23045
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed following fertilization and during embryogenesis in four neuronal cells (PubMed:23671427). Expressed in BAG, URX, AQR and PQR sensory neurons and cells in the head and tail in L1 larval stage and in the body wall muscle and vulval cells later in larval development (PubMed:23671427, PubMed:23946438). Expressed in cells of the pi uterine cell lineage from late L3 to mid L4 (PubMed:9834196).
messages: Expressed in body wall muscle and head and tail neurons (PubMed:9834196). Specifically expressed in O(2) and CO(2)-sensing neurons, including BAG and URX sensory neurons (PubMed:23671427).
messages: Hermaphrodites have an egg laying defective phenotype and a reduced brood size (PubMed:9834196). They display a protruding vulva phenotype and there is a failure of anchor cells to fuse to uterine seam cells (anchor cell-block) (PubMed:9834196). Animals also have defective vulval morphogenesis and gonad migration with increased pi cell divisions, which thus leads to an improper uterine-vulval connection (PubMed:9834196, PubMed:14668410). Defective response to CO(2) sensing (PubMed:23671427).
messages: Nucleus
messages: Probable transcription factor that is required for uterine and neuronal cell fate decisions (PubMed:9834196, PubMed:14668410, PubMed:23946438). Controls genes required for the specification and differentiation of O(2) and CO(2)-sensing neurons and for maintaining URX sensory neuronal cell fate (PubMed:23671427).

6239:CELE Y48G8AL.5
gene id: 6239:CELE_Y48G8AL.5
uniprot id: Q9BL15
uniprot id: V6CLJ9
uniprot id: V6CLP2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0035.14
gene id: 6239:CELE_B0035.14
uniprot id: Q17438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661).
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in many head neurons, vulva muscles and some tail neurons.

6239:CELE Y48G10A.4
gene id: 6239:CELE_Y48G10A.4
uniprot id: H2KML6
uniprot id: H2KML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

6239:CELE C46A5.3
gene id: 6239:CELE_C46A5.3
uniprot id: B2MZB1
uniprot id: P18834
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE B0564.4
gene id: 6239:CELE_B0564.4
uniprot id: Q17529
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE T21H8.1
gene id: 6239:CELE_T21H8.1
uniprot id: Q94071
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the liprin family. Liprin-beta subfamily.
messages: Defective locomotion, reduced pumping rate and reduced brood size (PubMed:19290026). Defects in presynaptic and postsynaptic structures and functions in muscle cells (PubMed:19290026). Resistant to the acetylcholinesterase inhibitor aldicarb and to levamisole, an agonist for postsynaptic acetylcholine receptors in muscles (PubMed:19290026). Double knockout with the syd-2 mutant ju37 increases resistance to aldicarb and levamisole (PubMed:19290026).
messages: Expressed in pharyngeal muscle, particularly posterior bulb, adjacent to the dorsal and ventral cord (but not in ventral cord neurons), and in body wall muscles.
messages: Involved in the regulation of synaptic function at neuromuscular junctions (PubMed:19290026). Together with the liprin-alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:19290026). Does not seem to be required for neuronal development (PubMed:19290026). May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity).

6239:CELE R06C7.10
gene id: 6239:CELE_R06C7.10
uniprot id: P02567
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Found exclusively in the pharyngeal muscle.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with itr-1 (via c-terminal coiled coil domain).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: myofibril

6239:CELE T16H12.4
gene id: 6239:CELE_T16H12.4
uniprot id: P34567
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTF2H2 family.
messages: Component of the 7-subunit TFIIH core complex composed of xpb-1, xpd-1, gtf-2H1, gtf-2H2C, gtf-2H3, Y73F8A.24 and gtf-2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of cyh-1, cdk-7 and mnat-1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus

6239:CELE D1046.5
gene id: 6239:CELE_D1046.5
uniprot id: Q18936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

6239:CELE Y48G9A.10
gene id: 6239:CELE_Y48G9A.10
uniprot id: Q9N3N3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE C35D10.10
gene id: 6239:CELE_C35D10.10
uniprot id: Q18484
names: Domain
names: Subcellular Location Annotation
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

6239:CELE F46C8.5
gene id: 6239:CELE_F46C8.5
uniprot id: P20271
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the anterior AFDL/R sensory neurons and BDUL/R and ALA interneurons, and in PVT, PVQL/R, DVC, PVNL/R, PVWL/R, PVR, PHCL/R, PHAL/R and PHBL/R cells in the tail region.
messages: Interacts (via LIM zinc-binding domains 1 and 2) with lim-7 (via LID domain) (PubMed:28676648). May interact with itself (PubMed:22207033). May interact with homeobox protein ceh-63 (PubMed:22207033).
messages: Late embryonic, larval and adult stages (PubMed:10774727). Expressed in the interneuron PVT during embryogenesis (PubMed:12490565). Expressed in the BDU neuron in the three-fold embryonic stage at about 430 minutes of development (PubMed:26096732).
messages: Nucleus
messages: Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1 and homeobox protein ceh-63, perhaps acting in concert with ceh-63 (PubMed:22207033). Binds to a motif including the sequence 5'-CTAAT-3' in regulatory promoter elements (PubMed:25614239). Confers thermosensory function to neurons (PubMed:10774727). Required for correct AFD-mediated thermotaxis (PubMed:10774727). In concert with homeobox protein ttx-1, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating receptor-type guanylyl cyclase gcy-8, gcy-18 and other genes (PubMed:25614239). Involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA (PubMed:20501595). Regulates its own expression and also that of homeodomain ceh-17, together forming an autoregulatory loop in the ALA neuron (PubMed:20501595, PubMed:26096732). Required for initial pathfinding of the ALA axons, but largely dispensable for axon migration (PubMed:20501595). Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein lim-6, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT (PubMed:12490565). Plays a role in controlling the peptidergic identity of the BDU neurons, regulating expression of flp-10, nlp-1, and nlp-15, thereby modulating the harsh touch response (PubMed:26096732).
messages: RNAi-mediated knockdown causes severe defects in the ALA neuron in young adults (PubMed:20501595). RNAi-mediated knockdown abolishes expression of helix-loop-helix protein mbr-1 in the interneuron DVC (PubMed:22207033).

6239:CELE F46H6.1
gene id: 6239:CELE_F46H6.1
uniprot id: Q20496
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rho GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

6239:CELE Y67D8C.9
gene id: 6239:CELE_Y67D8C.9
uniprot id: A8W765
uniprot id: H2L0M5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE C46F11.6
gene id: 6239:CELE_C46F11.6
uniprot id: Q7YX48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0280.3
gene id: 6239:CELE_B0280.3
uniprot id: P41994
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

6239:CELE F27D4.1
gene id: 6239:CELE_F27D4.1
uniprot id: Q93615
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).

6239:CELE B0554.5
gene id: 6239:CELE_B0554.5
uniprot id: P91003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE T28B8.4
gene id: 6239:CELE_T28B8.4
uniprot id: K7ZUR1
names: Similarity
messages: Belongs to the BLM10 family.

6239:CELE C53A5.8
gene id: 6239:CELE_C53A5.8
uniprot id: O17699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C47A4.2
gene id: 6239:CELE_C47A4.2
uniprot id: Q2EEN3
uniprot id: Q7JKL2
uniprot id: Q9U3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE T11A5.6
gene id: 6239:CELE_T11A5.6
uniprot id: G5EEZ6
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE F09E10.8
gene id: 6239:CELE_F09E10.8
uniprot id: Q19253
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the FNBP1 family.
messages: Cell junction
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Defective endocytosis by occytes characterized by either reduced or non-detectable yolk protein in the oocytes and by an accumulation of aggregated yolk in the pseudocoelomatic space (PubMed:19798448). This is more pronounced in the double knockout with toca-2 where nearly 100% of animals display this phenotype (PubMed:19798448). Double knockout mutants with toca-2 also produce 20% fewer eggs compared to wild-type animals and there is some embryonic lethality whereby the dying embryos display defective morphogenesis including failed epidermal enclosure with extruding gut cells and increased width of the intestinal lumen (PubMed:19798448). This perhaps results from failed intercalation and migration of hypodermal cells and irregular protein trafficking as indicated by an accumulation of the cell junction protein ajm-1 and diffuse localization of actin at cell junctions (PubMed:19798448, PubMed:26578656). These double mutants also demonstrate defective endosomal sorting of recycling cargo proteins such as mig-14 (PubMed:25775511). Double knockown with unc-84 results in defective hypodermal P-cell nuclear positioning with nuclei failing to migrate during larval development and a reduced number of GABA neurons (PubMed:23150597).
messages: Expressed in the germline and specifically in the gonads.
messages: Interacts (via SH3 domain) with wsp-1 (PubMed:19798448). Interacts with cdc-42 and (via SH3 domain) with wve-1 (PubMed:25775511).
messages: Plays a role in protein trafficking, actin organization and embryonic morphogenesis (PubMed:19798448). Potentially acts as cdc-42 effector (PubMed:25775511). May play a role in hypodermal P-cell nuclear positioning (PubMed:23150597). Together with toca-2, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14 (PubMed:19798448, PubMed:25775511). Also, together with toca-2, controls the distribution of actin at cell junctions (PubMed:19798448, PubMed:26578656).
messages: Recycling endosome
messages: Ubiquitously expressed in developing embryos.
messages: perinuclear region

6239:CELE C52A10.1
gene id: 6239:CELE_C52A10.1
uniprot id: Q95YC4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE M01D7.7
gene id: 6239:CELE_M01D7.7
uniprot id: G5EGU1
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

6239:CELE Y75B8A.30
gene id: 6239:CELE_Y75B8A.30
uniprot id: Q9XW79
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Expressed in embryos (at protein level).
messages: Methylation at the C-terminal Leu-333 is critical for interactions with regulatory subunits.
messages: Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis (PubMed:11896188, PubMed:25340746). During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM) (PubMed:11896188). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulting in chiasma formation (PubMed:11896188, PubMed:25340746). During oocyte meiosis II and probably together with regulatory subunit ppfr-1, may regulate microtubule severing by dephosphorylating and activating mei-1, a component of the katanin microtubule severing complex (PubMed:19087961).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits (By similarity). The regulatory subunits are likely to be ppfr-1, ppfr-2, ppfr-4 and smk-1 (PubMed:19087961). Interacts with mei-1 (PubMed:19087961).
messages: Severe embryonic lethality associated with a high incidence of male progeny (PubMed:25340746). RNAi-mediated knockdown causes 20 percent embryonic lethality and 18 percent larval lethality (PubMed:11896188). Abnormal meiosis and mitosis leading to defects in gametogenesis and embryogenesis (PubMed:11896188, PubMed:25340746). In spermatocytes, defects in the organization of astral microtubules (PubMed:11896188). In oocyte meiosis I, defects in autosomal chromosome pairing resulting from abnormal synapsis (PubMed:25340746). In embryos, RNAi-mediated knockdown causes abnormal mitosis due to defects in astral microtubules organization (PubMed:11896188). In a gain of function mei-1 (ct46) or in mel-26 (ct61sb4) mutant background, RNAi-mediated knockdown partially rescues embryonic lethality without affecting mei-1 expression levels and localization (PubMed:19087961).
messages: centrosome

6239:CELE F15A4.9
gene id: 6239:CELE_F15A4.9
uniprot id: O17812
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE F40F8.8
gene id: 6239:CELE_F40F8.8
uniprot id: D1MN74
uniprot id: Q20232
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y67D8C.22
gene id: 6239:CELE_Y67D8C.22
uniprot id: U4PRP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

6239:CELE T09A5.6
gene id: 6239:CELE_T09A5.6
uniprot id: P45966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for germ cell development and for transcriptional activation of certain stage-specific inducible promoters.
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE R04B5.8
gene id: 6239:CELE_R04B5.8
uniprot id: Q21705
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F23F12.3
gene id: 6239:CELE_F23F12.3
uniprot id: P46499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

6239:CELE Y110A7A.18
gene id: 6239:CELE_Y110A7A.18
uniprot id: Q9N585
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE ZK1067.1
gene id: 6239:CELE_ZK1067.1
uniprot id: A0A0K3AX35
uniprot id: B5BM27
uniprot id: B5BM28
uniprot id: P24348
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Expressed during L2 and L3 larval stages (PubMed:10359617). Highly expressed in vulval precursor cells P6.p in late L2 and early L3 stage larvae (PubMed:32053105).
messages: Expressed in vulval precursor cells (at protein level) (PubMed:10359617). Expressed in ALA neurons, 2 ventral head neurons, a single neuron in the tail, pharyngeal-intestinal valve and posterior arcade epithelial cells (PubMed:17891142).
messages: Larval lethality, lack of vulva formation, infertility and lack of male spicule formation (PubMed:2071015). RNAi-mediated knockdown causes sterility, a small decrease in the peak rate of sheath cell contractions and a delay in the onset of ovulatory contractions (PubMed:15194811). Restores normal pharyngeal pumping rate in 30 percent of animals overexpressing lin-3 (PubMed:17891142).
messages: Membrane
messages: Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis (PubMed:2071015, PubMed:8313880, PubMed:9491893, PubMed:20230814, PubMed:32053105). Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions (PubMed:9491893, PubMed:15194811). Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3 (PubMed:17891142).

6239:CELE C07A9.12
gene id: 6239:CELE_C07A9.12
uniprot id: Q5CZ51
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W02A2.2
gene id: 6239:CELE_W02A2.2
uniprot id: Q9XUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE T06C12.10
gene id: 6239:CELE_T06C12.10
uniprot id: O18037
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer). GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction (PubMed:19240113, PubMed:21325339). Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085). Together with cgt-3, plays a role in the trafficking of proteins such as mig-14 to the cell membrane in intestinal cells (PubMed:26115433).
messages: Expressed in excretory canals, pharyngeal intestinal valve, intestine and intestinal rectal valve.
messages: Knockdown of cgt-1 alone reduces brood size, while simultaneous knockdown of cgt-3 and cgt-1 results in a larval stage death (L1 lethal) phenotype (PubMed:19240113, PubMed:21325339). Double RNAi-mediated knockdown together with cgt-3 reduces the rate of development and restores the basolateral cell membrane localization of mig-14 in intestinal cells in a sgk-1 ok538 mutant background (PubMed:26115433).
messages: Membrane
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

6239:CELE C27A7.3
gene id: 6239:CELE_C27A7.3
uniprot id: P90755
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Membrane
messages: Probable phosphodiesterase.

6239:CELE F27E5.2
gene id: 6239:CELE_F27E5.2
uniprot id: G5ED66
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Expressed throughout embryogenesis and early larval development, predominantly in hypodermal cells, especially ventral P cells and their descendants.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality, vulval and gonad migration defects, and animals that survive have mild to severe body morphology defects (PubMed:26953187). A marker of the lateral hypodermal (seam cell) fate, scm, is expressed ectopically in some P cell nuclei during the early larval L1 stage (PubMed:26953187).
messages: Transcriptional activator (By similarity). Regulates the lateral/ventral epidermal cell fate decision (PubMed:26953187).

6239:CELE C24F3.3
gene id: 6239:CELE_C24F3.3
uniprot id: Q9XTD6
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal glands.
messages: Metalloprotease.
messages: Secreted

6239:CELE C06B3.5
gene id: 6239:CELE_C06B3.5
uniprot id: Q17704
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

6239:CELE Y48B6A.3
gene id: 6239:CELE_Y48B6A.3
uniprot id: Q9U299
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Expressed in the pharyngeal myoepithelium and intestine. Also expressed in several anterior neurons including the sensory neurons, as well as the interneuron PVT and the pharyngeal motorneuron M5.
messages: Expressed throughout all developmental stages. Detected in the M5 pharyngeal neuron only in larvae. Also persistently expressed in the intestine of adults past the molting stage.
messages: Interacts with paxt-1 (via N-terminus); the interaction is direct and results in stabilization of xrn-2 in the complex.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity (PubMed:19734881, PubMed:21397849). Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA (PubMed:19734881, PubMed:21397849, PubMed:26779609). Degradation role is enhanced when in complex with paxt-1 (PubMed:24462208, PubMed:26779609). Partially redundant to xrn-1 in miRNA guide strand degradation (PubMed:19734881, PubMed:21397849). Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA (PubMed:19734881, PubMed:21397849). Positively regulates molting of the pharyngeal cuticle (PubMed:16122351, PubMed:19734881).
messages: RNAi-mediated knockdown results in impaired miRNA degradation leading to accumulation of mature miRNA passenger (miR*) strands (PubMed:19734881, PubMed:21397849). Defective molting owing to failure to shed cuticle from the pharynx in the late L4-stage larvae (PubMed:16122351). Suppresses the vulval bursting phenotype of let-7 mutant (PubMed:19734881). Reduced paxt-1 expression (PubMed:24462208).
messages: Up-regulated prior to molting.

6239:CELE B0365.1
gene id: 6239:CELE_B0365.1
uniprot id: P90731
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

6239:CELE Y69H2.10
gene id: 6239:CELE_Y69H2.10
uniprot id: L8E6Z8
uniprot id: Q9U1U0
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T12G3.5
gene id: 6239:CELE_T12G3.5
uniprot id: Q22438
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

6239:CELE Y48E1A.1
gene id: 6239:CELE_Y48E1A.1
uniprot id: G5ED21
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6239:CELE F49C12.5
gene id: 6239:CELE_F49C12.5
uniprot id: Q20593
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE T28H10.2
gene id: 6239:CELE_T28H10.2
uniprot id: Q22857
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C01F1.1
gene id: 6239:CELE_C01F1.1
uniprot id: Q17558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

6239:CELE F27C1.2
gene id: 6239:CELE_F27C1.2
uniprot id: P91284
uniprot id: Q6BEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Late endosome membrane
messages: Membrane

6239:CELE Y51A2D.4
gene id: 6239:CELE_Y51A2D.4
uniprot id: Q9XXR3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in the intestine.
messages: H(+)-myo-inositol cotransporter (By similarity). Probably by promoting the transport of myo-inositol regulates intracellular osmosis in response to hyperosmotic stress (PubMed:21679696).
messages: Induced by hyperosmotic stress.

6239:CELE C05C10.6
gene id: 6239:CELE_C05C10.6
uniprot id: G5EES6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm
messages: Expressed in intestine (at protein level).
messages: Interacts with cdc-48.1.
messages: Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2.
messages: The PFU domain mediates interaction with ubiquitin.
messages: The PUL domain mediates the interaction with cdc-48.1 and/or cdc-48.2 C-terminus.

6239:CELE Y5H2B.2
gene id: 6239:CELE_Y5H2B.2
uniprot id: Q9N4Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: May interact with nuclear hormone receptor nhr-49.
messages: Nucleus
messages: Orphan nuclear receptor (PubMed:22511885). Involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptor nhr-49 (PubMed:22511885).

6239:CELE F55H2.2
gene id: 6239:CELE_F55H2.2
uniprot id: P34462
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE T05G5.7
gene id: 6239:CELE_T05G5.7
uniprot id: P34560
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in chromosome segregation and organization during mitosis.
messages: Belongs to the FAM82/RMD family.
messages: Defects in cytokinesis, spindle orientation, chromosome segregation, osmotic regulation and merotelic attachments of microtubules to chromosomes.
messages: Detected during metaphase and anaphase.
messages: Interacts with air-2.
messages: spindle pole

6239:CELE ZK637.13
gene id: 6239:CELE_ZK637.13
uniprot id: P30627
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: By hypoxia.
messages: Cytoplasm
messages: Expressed mainly in a subset of neuronal cells and in head muscular tissue.
messages: Homodimer.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: May be a globin and may play a role in oxygen transport.

6239:CELE F45E12.5
gene id: 6239:CELE_F45E12.5
uniprot id: Q20430
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

6239:CELE F20D12.6
gene id: 6239:CELE_F20D12.6
uniprot id: P26797
names: Developmental Stage
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Expressed in three pairs of neurons, the pharyngeal pace-maker neurons MC, the amphid neurons ADF and the phasmid neurons PHA, from 3-fold embryos until the adult stage (PubMed:23315936). Expression in ADFL/R was very low through the normal life cycle but increased greatly in the dauer larval stage (PubMed:23315936).
messages: Intron retention.
messages: Nucleus
messages: Probable transcription factor (PubMed:23315936). Required for MC motor neuron differentiation and function, including role in modulating pharyngeal pumping (PubMed:23315936). Regulates gene expression of FMRFamide-like neuropeptide flp-2 in MC motor neurons (PubMed:23315936). May act downstream of transcription factor pha-4 (PubMed:23315936).

6239:CELE C54D1.6
gene id: 6239:CELE_C54D1.6
uniprot id: Q18825
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abnormalities in vulval development due to incorrect cell fate specification, resulting in the following phenotypes, multivulva (Muv), protruding vulva (Pvl) and egg laying defective (Egl) (PubMed:9716532, PubMed:11063687, PubMed:11560894, PubMed:12441291). Mutants also show defects in Q neuroblast migration, uncoordinated movement (Unc) and reduced superoxidase dismutase levels (PubMed:15905404). Mutants can be rescued by wrm-1 and hmp-2 when expressed from the bar-1 promoter (PubMed:11560894). Double knockout with dpy-22 result in reduced body length, male tail morphology abnormalities (Mab) and dauer induction (PubMed:12441291). RNAi-mediated knockdown in the intestine decreases E.faecium-mediated protection against S.enterica infection (PubMed:35263319).
messages: Alleles mu63 and mu349 were originally reported (PubMed:9834184) as the mutations L130F and Q147STOP respectively. This is in conflict with WormBase and more recent literature (PubMed:15282167) which is represented in this entry.
messages: Belongs to the beta-catenin family.
messages: Cell junction
messages: Cytoplasm
messages: Detected throughout development from L1 to L4 and during adulthood (PubMed:15282167). Expressed in P3.p to P8.p vulval precursor cells in the late L1 and early L2 larval stage (PubMed:9716532). Not expressed in vulval precursor cells P1.p, P2.p, P9.p, P10.p or P11.p in the mid-L3 larval stage (PubMed:9716532). Expressed in other postembryonic cells including seam cells (PubMed:9716532).
messages: Expressed in body wall muscle cells, hypodermal seam cells, gonad sheath cells and vulval precursor cells.
messages: Interacts with apr-1 (PubMed:11560894). Interacts with axl-1 (PubMed:17601533). Interacts with daf-16 (PubMed:15905404). Interacts with lin-23 (PubMed:15820693). and. Interacts with pop-1 (via acidic region in N-terminus 1-44) (PubMed:10952315, PubMed:11560894). Interacts (via ARM repeats) with pry-1 (PubMed:12023307).
messages: Membrane
messages: Nucleus
messages: Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development (PubMed:10952315). Functions as a transcriptional activator but is dependent on the interaction with pop-1 (PubMed:10952315). Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses (PubMed:15820693). Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling (PubMed:9834184, PubMed:15905404). Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction (PubMed:9716532, PubMed:9834184, PubMed:11063687, PubMed:11560894, PubMed:12441291, PubMed:15905404). Functionally redundant to wrm-1 and hmp-2 (PubMed:11560894). In the intestine, plays a role in probiotic-mediated protection against infections by pathogens such as S.enterica (PubMed:35263319).

6239:CELE T22D1.10
gene id: 6239:CELE_T22D1.10
uniprot id: Q9GZH2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Expressed in gonadal cells.
messages: Forms homohexameric rings. May form a dodecamer with ruvb-1 made of two stacked hexameric rings.
messages: Nucleus
messages: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development (PubMed:25437307). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). Specifically, negatively controls the expression of ER homeostasis regulator ckb-2 in a cdc-48.1/2-dependent manner (PubMed:25652260).
messages: RNAi-mediated knockdown results in gonadal detachment during gonad migration (PubMed:25437307). RNAi-mediated knockdown upon tunicamycin-induced ER stress in a cdc-48.1 and/or cdc-48.2 mutant background (insensitive to tunicamycin-induced ER stress) restores the expression of ER homeostasis regulator, ckb-2 (PubMed:25652260).

6239:CELE C12C8.3
gene id: 6239:CELE_C12C8.3
uniprot id: Q9U489
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Expressed in body wall muscles, pharyngeal muscles and most neurons at all stages from late embryogenesis until adulthood. Expressed in hypodermal seam cells until the L4 stage.
messages: Heterochronic protein which acts downstream of let-7 in temporal patterning (PubMed:10882102, PubMed:30910805). Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production (PubMed:28933985). Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division (PubMed:10882102). Involved in post-transcriptional gene regulation, uses two independent pathways (PubMed:28157501). Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repression of translation (PubMed:28111013, PubMed:30910805). Degrades the mRNA of transcription factor dmd-3 to govern the timing and extent of male tail tip morphogenesis (PubMed:16806150, PubMed:18550714, PubMed:28111013, PubMed:30910805, PubMed:26811380, PubMed:30956008). Plays a role in the sexual maturation of the nervous system (PubMed:31264582).
messages: Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein.
messages: P-body
messages: RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown results in increased expression of dmd-3.
messages: The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.

6239:CELE K09C8.3
gene id: 6239:CELE_K09C8.3
uniprot id: Q21388
names: Cofactor
names: Function
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.

6239:CELE F26A3.3
gene id: 6239:CELE_F26A3.3
uniprot id: G5EBQ3
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE T02B11.1
gene id: 6239:CELE_T02B11.1
uniprot id: O16974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE R01B10.6
gene id: 6239:CELE_R01B10.6
uniprot id: Q8MXG1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y48E1B.12
gene id: 6239:CELE_Y48E1B.12
uniprot id: O45952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family. Highly divergent.
messages: Component of the CPC complex which consists of icp-1; csc-1; bir-1 and air-2. Within the complex interacts with Aurora B/air-2, bir-1 and icp-1.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA.
messages: Nucleus
messages: centromere
messages: spindle

6239:CELE F54C9.11
gene id: 6239:CELE_F54C9.11
uniprot id: Q20759
names: Similarity
messages: Belongs to the SEC2 family.

6239:CELE M7.3
gene id: 6239:CELE_M7.3
uniprot id: Q21593
names: Similarity
messages: Belongs to the BicC family.

6239:CELE T11G6.1
gene id: 6239:CELE_T11G6.1
uniprot id: P34183
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (Probable). Required for germ cell development (PubMed:21464306).
messages: RNAi-mediated knockdown results in gonadal defects including smaller, narrower gonads and reduced fertility with either no oocytes or no fertilized eggs in the majority of animals (PubMed:21464306). RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress (PubMed:23076791).

6239:CELE C56G7.1
gene id: 6239:CELE_C56G7.1
uniprot id: Q09510
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arrest at the 2-fold embryonic stage which is associated with a defect in embryo elongation and failure of seam cells to elongate to a narrow morphology. No abnormalities in body wall or pharyngeal muscles and in the number of hypodermal cells.
messages: Cytoplasm
messages: Expressed at the bean stage in the lateral hypodermal seam cells and then throughout embryogenesis and into larval stages.
messages: Expressed in the spermathecal and uterine walls. Weak expression in gonadal sheath and intestinal muscle. Not detected in vulval, pharyngeal or body wall muscles.
messages: May be phosphorylated by let-502 or/and pak-1 and dephosphorylated by mel-11 to regulate its activation and myosin II-mediated contraction.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles (PubMed:19675126). Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity (PubMed:10427096).
messages: This chain binds calcium.
messages: cytoskeleton

6239:CELE Y50E8A.4
gene id: 6239:CELE_Y50E8A.4
uniprot id: Q25AR8
uniprot id: Q8I4C9
uniprot id: Q9U277
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

6239:CELE B0034.3
gene id: 6239:CELE_B0034.3
uniprot id: G5ED46
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A proportion of the protein is proteolytically cleaved before the transmembrane domain in neurons, leading to release in the extracellular space.
messages: Acts as aregulator of glutamate signaling in the sensory neurons by inhibiting the activity of command interneurons, thereby negatively regulating motor circuit activity and locomotion.
messages: Belongs to the calsyntenin family.
messages: Cell adhesion molecule involved in associative learning and memory (PubMed:18381821, PubMed:25035490, PubMed:19287492, PubMed:29529030). Acts as a regulator of GABAergic synaptic transmission at neuromuscular junctions by regulating GABA synaptic vesicle precursor transport: possibly functions as a cargo adapter for unc-104-mediated transport of synaptic vesicle precursors (PubMed:29529030). Promotes localization of isoform c of daf-2 (daf-2c) to synaptic regions by acting as a signaling adapter between klc-2 and daf-2c (PubMed:25035490).
messages: Defects in associative learning, such as temperature learning, olfactory adaptation and integration of two sensory signals (PubMed:18381821, PubMed:19287492). Mutants display hyperactive sensory neurons, resulting in accelerated locomotion and motor circuit activity (PubMed:29475851). Worms show a reduced number of GABA vesicles at the synapse resulting in less GABA release from the presynaptic GABAergic motor neurons (PubMed:29529030).
messages: Golgi apparatus membrane
messages: Interacts with isoform c of daf-2 (daf-2c); promoting daf-2c localization to synaptic regions (PubMed:25035490). Interacts with klc-2 (PubMed:25035490). Interacts with unc-104 (PubMed:29475851).
messages: Perikaryon
messages: Secreted
messages: Synaptic cleft
messages: Widely expressed in the nervous system (PubMed:18381821). Highly expressed in many head neurons, including most amphid sensory neurons (PubMed:18381821). Also expressed in other tissues, such as intestine and gonadal sheath cells (PubMed:18381821).
messages: axon

6239:CELE C24H11.6
gene id: 6239:CELE_C24H11.6
uniprot id: Q9XVD2
names: Subunit
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.

6239:CELE C07G2.3
gene id: 6239:CELE_C07G2.3
uniprot id: P47209
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE E03A3.2
gene id: 6239:CELE_E03A3.2
uniprot id: Q19046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

6239:CELE E04F6.13
gene id: 6239:CELE_E04F6.13
uniprot id: Q95QP0
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE H12C20.6
gene id: 6239:CELE_H12C20.6
uniprot id: Q95ZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y15E3A.1
gene id: 6239:CELE_Y15E3A.1
uniprot id: Q9U2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE B0303.9
gene id: 6239:CELE_B0303.9
uniprot id: P34260
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:25273556, PubMed:26783301, PubMed:27558849). Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556). Required for endosome/lysosome fusion (PubMed:26783301, PubMed:27558849). Required for early embryonic development (PubMed:27558849).
messages: Probable component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41 (PubMed:24501423, PubMed:25273556). Interacts with spe-39 (PubMed:19109425).
messages: Ubiquitously expressed at high levels in somatic tissues including the pharynx, muscles, hypodermis, neurons, coelomocytes and spermatheca (PubMed:27558849). Expressed in the intestine (PubMed:25273556, PubMed:27558849).
messages: Viable, and develop into fertile adults, but their progeny arrest before embryonic morphogenesis (PubMed:27558849). Defective endosome/lysosome size and fusion, and delayed endocytic trafficking to lysosomes in coelomocytes (PubMed:26783301, PubMed:27558849). Reduced number of gut granules in the adult intestine (PubMed:24501423, PubMed:27558849). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in the accumulation of lysosomal proteins such as lmp-1 in early endocytic compartments, and the formation of large late endosomes/lysosomes, but with simultaneous expression of rab-5- and rab-7-positive vesicles on the basal side of gut cells (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.2 results in defective protein trafficking to lysosomal compartments, and an irregular distribution of vesicles of various sizes throughout the gut cells. RNAi-mediated knockdown in a sand-1 mutant background results in no viable offspring (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 in a sand-1 mutant background rescues the large endosome phenotype and the defective protein trafficking to lysosomal compartments in the sand-1 single mutant, but still results in lethality (PubMed:25273556). Double knockout with tbc-2 or single knockout in a constitutively active rab-5 mutant background, rescues the large endosome formation defect in coelomocytes in the individual tbc-2 single and constitutively active rab-5 mutants (PubMed:27558849).

6239:CELE F42A10.8
gene id: 6239:CELE_F42A10.8
uniprot id: P98061
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C16D6.2
gene id: 6239:CELE_C16D6.2
uniprot id: A0A078BS36
uniprot id: A0A078BTK0
uniprot id: A0A0K3AYF5
uniprot id: O62062
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F09E5.11
gene id: 6239:CELE_F09E5.11
uniprot id: Q19259
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F37B4.2
gene id: 6239:CELE_F37B4.2
uniprot id: O45168
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE ZK180.1
gene id: 6239:CELE_ZK180.1
uniprot id: G5ECB2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-1.
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity). Along with gbb-1, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679). Regulates locomotory behavior in response to GABA release by GABAergic motor neurons (PubMed:18614679, PubMed:21613582).
messages: Expressed in cholinergic motor neurons.
messages: Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Increased locomotion and body curvature (deeper bends) in response to induced GABA release of GABAergic motor neurons, which in wild-type animals results in acute body relaxation (PubMed:21613582). Double knockout with gbb-1 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the muscarinic acetylcholine receptor gar-2 results in a slight increase in sensitivity to Aldicarb and accelerated paralysis 50 minutes following exposure to Aldicarb as compared to the gar-2 and gbb-2 single mutants (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582).
messages: May form a heterodimer with gbb-1.

6239:CELE Y110A2AR.1
gene id: 6239:CELE_Y110A2AR.1
uniprot id: Q9N488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE F42A10.9
gene id: 6239:CELE_F42A10.9
uniprot id: Q65ZK1
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

6239:CELE F43D9.4
gene id: 6239:CELE_F43D9.4
uniprot id: Q20363
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F10D2.5
gene id: 6239:CELE_F10D2.5
uniprot id: O16914
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58E6.10
gene id: 6239:CELE_F58E6.10
uniprot id: L8E946
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed in 40 neurons located in the head, which can be divided into 15 anatomically distinct classes; unc-42-expressing neurons are unrelated by lineage but are synaptically interconnected.
messages: Expressed in neurons from 260 minutes of embryogenesis, comma stage and into adulthood (at protein level) (PubMed:10207148). Expressed in late stage (3 and a half-fold) embryos in at least 20 pairs of neurons of the head, including the AVA, AVD and AVE interneurons, ASH sensory neurons, and RMD and SMB motor neurons (PubMed:10207148). Expressed at high levels in the AIN, AVH, AVJ, AVK, RIV, SAA and SIB interneurons (PubMed:10207148). At larval L2 stage, expressed in the tail in the PVT neuron (PubMed:10207148).
messages: Nucleus
messages: Probable transcription factor (PubMed:9216999, PubMed:11222641, PubMed:34165428). Required for initial outgrowth and pathfinding of axon growth cones along the ventral nerve cord (VNC) (PubMed:9216999, PubMed:11222641, PubMed:34165428). Involved in specifying neuron identity, in concert with nuclear hormone receptor family member fax-1, or with transcription factors unc-3, cfi-1, or hlh-34, perhaps acting via positive feedforward loops (PubMed:10207148, PubMed:16183052, PubMed:34165428). Establishes electrically- and chemically-interconnected neuron circuits, acting by modulating the expression of neurotransmitter pathway genes, neurotransmitter receptors, neuropeptides, and neuropeptide receptors (PubMed:34165428). Required for cholinergic and glutamatergic synaptic communication (PubMed:34165428). Plays a role in locomotion and mechanosensory response, perhaps via regulation of chemosensory receptor expression, and is required for expression of glutamate receptors, including glr-1, glr-4 and glr-5 (PubMed:10207148, PubMed:11222641, PubMed:34165428).

6239:CELE C01F6.9
gene id: 6239:CELE_C01F6.9
uniprot id: G5EDA6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE T14G10.1
gene id: 6239:CELE_T14G10.1
uniprot id: A0A061AE05
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway (PubMed:16497669). The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase) (PubMed:16497669). Required for normal growth and development (PubMed:16497669). Involved in several aspects of both embryonic and postembryonic development, including molting, changes in cell shape, and patterning of epithelial and muscle cells (PubMed:16497669).
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.
messages: Lethal phenotype (PubMed:16497669). Embryos hatch, initiate growth and development, but arrest at the L2 or L3 larval stages (PubMed:16497669). Abnormal cuticle (PubMed:16497669). RNAi-mediated knockdown causes a 42% decrease in 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthesis activity (PubMed:16497669). Reduced sulfation of disaccharides of heparan sulfate (HS) proteoglycans (PubMed:16497669). Defects in cell shape of epidermis and patterning of body wall muscle cells (PubMed:16497669). Some phenotypes only observed when grown at 25 degrees Celsius; such as shortened malformed tail, exacerbated molting defects, blistering, and sterility (PubMed:16497669).
messages: Nucleus
messages: Widely expressed in epidermal cells, gland cells and in amphid sheath cells throughout development, but not in muscle cells and neurons.

6239:CELE T09A5.11
gene id: 6239:CELE_T09A5.11
uniprot id: P45971
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal (PubMed:23691084). Embryogenesis proceeds more slowly and embryos are osmo-sensitive (PubMed:23691084). RNAi-mediated knockdown reduces lifespan (PubMed:36173858).
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). Required for normal lifespan (PubMed:36173858).

6239:CELE R06A4.7
gene id: 6239:CELE_R06A4.7
uniprot id: O17514
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
messages: Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, while it is expressed at intermediate levels in the germline of L4 larvae.
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells (PubMed:9609829, PubMed:29702639). Expressed in the hypoderm (PubMed:29702639).
messages: Interacts directly with mes-6 via its N-terminal domain (PubMed:11320248). Forms a heterotrimeric complex with mes-3 and mes-6 (PubMed:11320248, PubMed:15380065). Does not interact with mes-4 (PubMed:11320248).
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230). PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259). Involved in the negative regulation of lifespan in a germline-independent fashion (PubMed:22212395).
messages: RNAi-mediated knockdown results in extended lifespan in wild type worms and in a glp-1(e2141) mutant background which lacks a germline (PubMed:22212395). Also leads to reduced H3K27me3 levels on metaphase chromosomes (PubMed:26904949). Double RNAi-mediated knockdown together with mes-6 RNAi results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230). In addition in this background in males, there is ectopic expression of egl-5 in the mid-body region including in seam cells and hypodermal nuclei, and there is ectopic ray formation (PubMed:17574230).

6239:CELE Y6B3B.11
gene id: 6239:CELE_Y6B3B.11
uniprot id: Q9XWF0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although thought to contribute to D(4)-dafrachronic acid biosynthesis, the latter may not be present at physiologically relevant concentrations in C.elegans and comparative metabolomics would indicate 7-dehydrogenase activity and participation in D(7)-dafrachronic acid biosynthesis instead.
messages: Belongs to the 3-beta-HSD family.
messages: Expressed exclusively in the neuron-like XXX(L/R) cells through all four larval stages and becomes fainter in adults.
messages: Hydroxysteroid dehydrogenase involved in the biosynthesis of dafrachonic acids (PubMed:18495818, PubMed:20178781, PubMed:24411940). Catalyzes the dehydrogenation of cholesterol or its derivatives and the isomerization of the double carbon bond on the sterol ring. Modifies sterols into a Delta(4)-3-keto-sterols such as cholest-4-en-3-one, precursor of Delta(4)-dafachronic acid (PubMed:18495818). Contributes to the production of Delta(7)-dafachronic acid in the XXX cells (PubMed:24411940). Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12 suppressing dauer formation and inducing reproductive growth (PubMed:18495818, PubMed:24411940). Acts in parallel to AKT-1 to promote reproductive development via DAF-16/FoxO and DAF-12 (PubMed:20178781).
messages: Membrane
messages: Mutants are hypersensitive to pheromone induction and form dauers more readily than the wild-type.

6239:CELE ZK632.4
gene id: 6239:CELE_ZK632.4
uniprot id: P34650
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

6239:CELE F59G1.1
gene id: 6239:CELE_F59G1.1
uniprot id: Q21054
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer). GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction. Seems to be the major active form in the nematode (PubMed:19240113, PubMed:21325339). Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085). Together with cgt-1, plays a role in the trafficking of proteins such as mig-14 to the cell membrane in intestinal cells (PubMed:26115433).
messages: Expressed in pharyngeal intestinal valve, intestinal rectal valve and hypodermis.
messages: Membrane
messages: Reduced brood size. Reduced glucosyl-ceramide content and expression at cell surface. Increased expression of sphingomyelins and sphingomyelin clustering at cell surface. Loss of function in the germline leads to defects in oocyte formation and early embryonic divisions and shortened body length. Loss of function in somatic cells may lead to L1 arrest (PubMed:19240113, PubMed:21325339). Double RNAi-mediated knockdown together with cgt-1 reduces the rate of development and restores the basolateral cell membrane localization of mig-14 in intestinal cells in a sgk-1 ok538 mutant background (PubMed:26115433).
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

6239:CELE C30H6.7
gene id: 6239:CELE_C30H6.7
uniprot id: O45279
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

6239:CELE Y11D7A.14
gene id: 6239:CELE_Y11D7A.14
uniprot id: Q9XWR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F59E12.13
gene id: 6239:CELE_F59E12.13
uniprot id: G5EFP5
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.
messages: Expressed in larvae and adult.
messages: Golgi stack membrane
messages: Inhibited by Ni(2+) and to a lesser extent by Mn(2+) and Cu(2+).
messages: N-glycosylated.
messages: No obvious defect in N-glycan composition.
messages: Unlike other alpha-(1,3)-fucosyltransferases, appears not to require a divalent metal cation as cofactor.

6239:CELE Y66D12A.8
gene id: 6239:CELE_Y66D12A.8
uniprot id: G2HK16
uniprot id: Q95Q06
names: Similarity
messages: Belongs to the STEEP1 family.

6239:CELE F46E10.8
gene id: 6239:CELE_F46E10.8
uniprot id: Q9UAV3
names: Similarity
messages: Belongs to the peptidase C12 family.

6239:CELE F58A4.4
gene id: 6239:CELE_F58A4.4
uniprot id: G3MTW9
uniprot id: P34471
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
messages: Heterodimer of a small subunit and a large subunit.
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).

6239:CELE T25F10.5
gene id: 6239:CELE_T25F10.5
uniprot id: Q23049
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:17000880, PubMed:22022287, PubMed:22922713, PubMed:27930654). Plays a role in guanylyl cyclase localization in the ring-like structures at the base of the finger compartment in AFD sensory neurons (PubMed:25335890).
messages: Expressed from the embryonic stage to adulthood. Expressed in embryos from the 1.5-fold stage, with expression increasing to the 3-fold stage. Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head at larval stages L1 and L2. Expressed in both phasmid neurons PHA and PHB in the tail and in the PDE sensory neuron in the mid-body at larval stage L3 and L4.
messages: Expressed in head and tail neurons (PubMed:15231740). Expressed in ciliated male tail-neurons (PubMed:14520415). Expressed in thermosensory and CO(2) sensory AFD neurons (PubMed:25335890).
messages: Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements (PubMed:22022287). May exhibit defective chemotaxis tendencies (PubMed:15231740). Defective sensory cilia structure and function (PubMed:15231740, PubMed:22022287). This is characterized by increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins such as rab-28 along the ciliary axoneme (PubMed:15231740, PubMed:27930654). Disrupted assembly of the BBSome complex at the base of the cilia (PubMed:22922713). Impaired localization of the guanylyl cyclase proteins, gcy-8, gcy-18 and gcy-23, within AFD sensory neurons, with accumulation along the dendrite as well as in the finger compartment of AFD neurons (PubMed:25335890). Thermotaxis defects and impaired tendencies to migrate to a food source (PubMed:25335890).
messages: Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9.
messages: cilium
messages: cilium axoneme
messages: cilium basal body

6239:CELE D1005.3
gene id: 6239:CELE_D1005.3
uniprot id: Q18909
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Cytoplasm
messages: Expressed in touch and motor neurons.
messages: In response to methylmercury.
messages: May interact with transcription factor ets-4 (PubMed:26484536). May interact (via N-terminus) with nipi-3 (PubMed:27927209). May interact (via N-terminus) with importin subunit alpha ima-3 (PubMed:31417366).
messages: Nucleus
messages: Plays a role in repressing the response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:27927200). However, is also reported to play a protective role in the response to infection by P.aeruginosa (PubMed:28662060). These differences may be due to conditions of infection or perhaps genetic background.
messages: RNAi-mediated knockdown suppresses lifespan reduction caused by infection by the Gram-negative bacterium P.aeruginosa when combined with simultaneous knockdown of nipi-3 (PubMed:27927200). Knockdown reduces survival due to infection by the Gram-negative bacterium P.aeruginosa in a valine--tRNA ligase glp-4 mutant background (PubMed:28662060).
messages: Synapse
messages: Transcription factor (By similarity). Binds to promoter regions of target genes, perhaps at the motif 5'-[AGCT]TT[AGT][TC]GAAA[ACT]-3' (PubMed:27927209). Modulates expression of genes involved in development and in stress responses, including those regulating the p38/MAPK signaling pathways such as MAPKK sek-1 and phosphatase vhp-1 (PubMed:27927209, PubMed:34407394). Involved in innate immunity (PubMed:27927200, PubMed:28662060, PubMed:34407394). Plays a role in repressing the response to infection by the Gram-negative bacterium P.aeruginosa, perhaps acting independently of the pmk-1 or pmk-3 p38/MAPK pathways (PubMed:27927200). However, also plays a protective role in the response to infection by P.aeruginosa (PubMed:28662060). Required in axonal regrowth following injury and synaptogenesis (PubMed:19737525, PubMed:31417366, PubMed:26484536). Following axon injury, in concert with transcription factor ets-4, activates expression of receptor tyrosine kinase svh-2 (PubMed:26484536). May function downstream of the Ca2+-activated p38/MAPK pathway to promote axon regeneration (PubMed:26484536). Plays a role in modulating polymerization of neuronal microtubules (PubMed:21368137). Involved in modulating lipid homeostasis (PubMed:31851340).
messages: Widely expressed in most postembryonic tissues, including epidermis, muscles, pharynx, intestine and neurons.
messages: axon

6239:CELE Y38H6C.14
gene id: 6239:CELE_Y38H6C.14
uniprot id: Q9XX47
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FAM161 family.
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme

6239:CELE T01H10.6
gene id: 6239:CELE_T01H10.6
uniprot id: Q22085
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE T01B11.3
gene id: 6239:CELE_T01B11.3
uniprot id: P91409
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

6239:CELE F07B7.3
gene id: 6239:CELE_F07B7.3
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y47G6A.9
gene id: 6239:CELE_Y47G6A.9
uniprot id: Q9N3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

6239:CELE K08F4.8
gene id: 6239:CELE_K08F4.8
uniprot id: P53020
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F08G5.5
gene id: 6239:CELE_F08G5.5
uniprot id: Q19222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C25B8.3
gene id: 6239:CELE_C25B8.3
uniprot id: P43510
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y39G8C.4
gene id: 6239:CELE_Y39G8C.4
uniprot id: Q7YTG4
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE F43G9.5
gene id: 6239:CELE_F43G9.5
uniprot id: Q93716
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

6239:CELE W02B9.1
gene id: 6239:CELE_W02B9.1
uniprot id: Q967F4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins (PubMed:25938815, PubMed:25850673). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:25938815, PubMed:25850673). Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (PubMed:26412237).
messages: Cell junction
messages: Cell membrane
messages: Embryonic lethal (PubMed:20689042, PubMed:25850673). Hammerhead phenotype characterized by morphogenetic defects before the start of body elongation, due to improper closure of hypodermis (PubMed:9531567, PubMed:25850673). Humpback phenotype with embryos containing dorsal humps (PubMed:20689042). Embryos also exhibit defective actin structures including loss of actin at cell-cell junctions and detached thick actin bundles called circumferential filament bundles that insert at right angles to junctional actin (PubMed:20689042). RNAi-mediated knockdown results in ingression defects in primordial germ cells (PubMed:22675206).
messages: Expressed in AQR sensory neurons at the L1 larval stage.
messages: Expressed in all embryonic blastomeres at early stages of development (PubMed:9531567, PubMed:25938815). Expressed throughout gastrulation and in primordial germ cells (PubMed:22675206).
messages: Expressed in epidermal cells (at protein level) (PubMed:9531567).
messages: Isoform a is required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567, PubMed:12847081). Required for proper localization of other junctional components, such as hmp-1, hmp-2, jac-1 and pac-1 (PubMed:9531567, PubMed:25938815). Recruitment of pac-1 is required to establish cell polarity, independent of its role in cell adhesion (PubMed:25938815). Required for primodial germ cell ingression and adherence to endodermal cells during gastrulation (PubMed:20515680, PubMed:22675206).
messages: Isoform b is involved in axonal guidance in a subset of motor neurons.
messages: Monomer in solution (PubMed:20689042). Isoform a is a component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:20689042, PubMed:25850673). Isoform a interacts with hmp-2; the interaction is direct (PubMed:10952315, PubMed:20689042, PubMed:25850673, PubMed:26412237). Isoform a interacts (via intracellular domain) with jac-1 (PubMed:12847081, PubMed:25938815).
messages: Neuron-specific.
messages: Phosphorylation at T-2912 increases the binding affinity for hmp-2.
messages: Sumoylated. Sumoylation prevents accumulation at adherens junctions and decreases the binding affinity for hmp-2.
messages: The cytoplasmic domain is necessary for binding to jac-1.
messages: adherens junction
messages: dendrite

6239:CELE F54E12.1
gene id: 6239:CELE_F54E12.1
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts (via N-terminal tail mono-acetylated on Lys-15) with swsn-4 (via Bromo domain); the interaction is direct (PubMed:34473995).

6239:CELE C35A5.1
gene id: 6239:CELE_C35A5.1
uniprot id: Q18469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE Y116A8C.12
gene id: 6239:CELE_Y116A8C.12
uniprot id: Q9U2S4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

6239:CELE ZK546.14
gene id: 6239:CELE_ZK546.14
uniprot id: Q23525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF6 family.
messages: nucleolus

6239:CELE F25D7.5
gene id: 6239:CELE_F25D7.5
uniprot id: G5EDD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C24F3.2
gene id: 6239:CELE_C24F3.2
uniprot id: Q9XXK8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

6239:CELE C54C8.5
gene id: 6239:CELE_C54C8.5
uniprot id: O17708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F46F3.1
gene id: 6239:CELE_F46F3.1
uniprot id: H2L2F8
uniprot id: Q9XVN4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T01B7.4
gene id: 6239:CELE_T01B7.4
uniprot id: P52018
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE T27D1.1
gene id: 6239:CELE_T27D1.1
uniprot id: Q09637
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Co-expressed with pdi-1 in the syncytial hypodermis.
messages: Expression significantly up-regulated in the middle of the L3 (22 hours) and L4 (26 hours) larval stages.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens.

6239:CELE F32D1.5
gene id: 6239:CELE_F32D1.5
uniprot id: O16294
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

6239:CELE C05C10.3
gene id: 6239:CELE_C05C10.3
uniprot id: Q09450
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Homodimer.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

6239:CELE T10H9.2
gene id: 6239:CELE_T10H9.2
uniprot id: O76411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Expressed in AIA sensory neurons.
messages: Interacts (via cytoplasmic domain) with fsn-1 (via SPRY domain).
messages: Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway (PubMed:11063683, PubMed:18674914). Regulates integration of conflicting sensory cues in AIA interneurons (PubMed:21414922). May act as a receptor for hen-1 (PubMed:18674914, PubMed:21414922). In AWA neurons, together with hen-1, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl (PubMed:28924007).

6239:CELE Y71H9A.1
gene id: 6239:CELE_Y71H9A.1
uniprot id: G5EBQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y39E4A.2
gene id: 6239:CELE_Y39E4A.2
uniprot id: O45923
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: By B.thuringiensis pore-forming toxin Cry5B (PubMed:15256590). Isoform a: Not induced by zinc. Isoform b: Induced by zinc specifically in intestinal cells (PubMed:23717214).
messages: Cytoplasmic vesicle membrane
messages: Isoform a: Expressed in the hypodermis and the intestine. Isoform b: Expressed in the intestine, head neurons, seam cells, hypodermis, and the vulva.
messages: Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc (PubMed:23717214). Involved in cadmium resistance, possibly by promoting its transport from cells (PubMed:15256590). Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway (PubMed:15256590).
messages: RNAi-mediated knockdown causes hypersensitivity to low, chronic doses of the B.thuringiensis pore-forming toxin Cry5B and heavy metal Cd(2+) exposure.

6239:CELE F01F1.6
gene id: 6239:CELE_F01F1.6
uniprot id: P46562
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

6239:CELE F59C6.8
gene id: 6239:CELE_F59C6.8
uniprot id: Q93834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE W01F3.1
gene id: 6239:CELE_W01F3.1
uniprot id: O45879
uniprot id: Q9BI60
names: Similarity
messages: Belongs to the FAM151 family.

6239:CELE F56C9.1
gene id: 6239:CELE_F56C9.1
uniprot id: P48727
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Expressed at early embryonic stages.
messages: Expressed in gonads, nervous system, intestine and muscles.
messages: Inhibited by okadaic acid.
messages: Interacts with lab-1; the interaction is direct.
messages: Nucleus
messages: Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA-mediated genome silencing pathway (PubMed:30921322). Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment (PubMed:18923084). Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Promotes small RNA-mediated genome silencing over multiple generations (PubMed:30921322). Essential for embryogenesis.

6239:CELE C45E1.1
gene id: 6239:CELE_C45E1.1
uniprot id: O44960
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE H21P03.2
gene id: 6239:CELE_H21P03.2
uniprot id: Q9XTV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

6239:CELE C44B7.9
gene id: 6239:CELE_C44B7.9
uniprot id: Q18598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

6239:CELE Y53C12B.3
gene id: 6239:CELE_Y53C12B.3
uniprot id: O18218
uniprot id: O62486
names: Similarity
messages: Belongs to the nanos family.

6239:CELE Y67D8C.10
gene id: 6239:CELE_Y67D8C.10
uniprot id: B7CED8
uniprot id: U4PMD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F33A8.9
gene id: 6239:CELE_F33A8.9
uniprot id: Q9NAQ4
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C35A5.6
gene id: 6239:CELE_C35A5.6
uniprot id: Q18474
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T24F1.3
gene id: 6239:CELE_T24F1.3
uniprot id: Q22744
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the pharynx, epithelial cells, ciliated neurons in the head, body wall muscles, hypodermis, vulva, gonadal sheath cells, tail hypodermis and in coelomocytes.
messages: Expressed in the pharynx, neurons and vulva.
messages: In embryos, expressed in epidermal cells during the dorsal intercalation and ventral enclosure.
messages: Interacts with rab-39 (GTP-bound form) (PubMed:23294242). Interacts (via SARAH domain) with cst-1; the interaction is required for the phosphorylation of cst-1 (PubMed:23103556).
messages: Involved in embryonic morphogenesis (PubMed:23103556). Plays a role in the organization of apical filamentous actin in epithelial cells of the developing embryo (PubMed:23103556). May play a role in let-60-mediated vulval development (PubMed:23103556). May induce nuclear condensation (PubMed:23103556). Positively regulates the oxidative stress response, and this may be in association with the small GTPase rab-39 (PubMed:23294242). Not required for muscle integrity (PubMed:23103556).
messages: RNAi-mediated knockdown results in reduced survival in response to oxidative stress induced by sodium arsenite.
messages: cytoskeleton

6239:CELE F28B3.7
gene id: 6239:CELE_F28B3.7
uniprot id: O01789
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their SMC hinge domain, scc-1 which links them, and scc-3. Interacts with smc-3, scc-1, scc-3 and tim-1.
messages: Defective chromosome segregation during germline mitosis, resulting in aneuploidy (PubMed:12827206). RNAi-mediated knock-down is embryonic lethal and results in aberrant chromosome segregation in mitosis (PubMed:12827206, PubMed:12808038).
messages: Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis (PubMed:12808038, PubMed:12827206). Central component of cohesin complex (PubMed:12827206). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).
messages: Nucleus

6239:CELE F55G7.2
gene id: 6239:CELE_F55G7.2
uniprot id: Q20856
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

6239:CELE F22A3.1
gene id: 6239:CELE_F22A3.1
uniprot id: A8WFJ9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Delayed larval development and increased lifespan, but overall resulting animals have normal morphology and fecundity (PubMed:20862312). Reduced egg-laying rate, but older hermaphrodites produce more progeny (PubMed:20862312). Both decreased expression of genes, such as the lipoprotein vit-5, which is related to life span regulation, and increased expression of genes such as lys-7, which is a lysosomal protein (PubMed:20862312). Reduced expression of genes such as svh-2 in response to axon injury and as a result, there is reduced axon regeneration of D-type motor neurons (PubMed:26484536). RNAi-mediated knockdown results in reduced expression of the RNA-binding protein rege-1 (PubMed:27746047).
messages: Expressed in cells of the anterior and posterior bulbs of the pharynx, seam cells, a few unidentified cells of the vulva, the hypodermis, several unidentified neurons, labial socket cells of the head and rectal cells.
messages: Expressed in intestinal cells from the 3-fold stage of embryogenesis to adulthood.
messages: May interact with cebp-1.
messages: Nucleus
messages: Phosphorylation is required for axon regeneration.
messages: The N-terminal part (1-345) is responsible for activating transcription, but this action may be modulated by the PNT domain which acts to repress transcription.
messages: Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences (PubMed:20862312, PubMed:26484536). Both positively and negatively regulates the expression of target genes (PubMed:20862312). Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity (PubMed:20862312). Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration (PubMed:26484536). Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too has been implicated in the control of fat accumulation (PubMed:27746047).

6239:CELE M02H5.7
gene id: 6239:CELE_M02H5.7
uniprot id: G5EDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F14D12.4
gene id: 6239:CELE_F14D12.4
uniprot id: H2KZ92
uniprot id: Q27433
uniprot id: Q8MQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family.
messages: Component of a non-voltage-gated amiloride-sensitive cation channel complex (also called the degenerin channel complex) composed of at least the mec-2, mec-4, mec-6 and mec-10 subunits; the complex mediates mechanotransduction in touch cells (PubMed:12478294). Interacts with mec-6 and mec-4 (PubMed:12478294).
messages: Membrane
messages: Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:12478294). Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons.

6239:CELE R11E3.5
gene id: 6239:CELE_R11E3.5
uniprot id: H2L0B0
uniprot id: Q86PJ5
uniprot id: Q8MXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y41C4A.9
gene id: 6239:CELE_Y41C4A.9
uniprot id: Q9U2I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

6239:CELE T02E9.3
gene id: 6239:CELE_T02E9.3
uniprot id: O45732
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C34H3.2
gene id: 6239:CELE_C34H3.2
uniprot id: Q9N5X6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Expressed in the intestine from embryogenesis to adulthood. Highly expressed in the most anterior and posterior parts of the intestine in hatched larva. Also expressed in cells outside of the intestine near the anus in hatched larva.
messages: May function as transcription regulator (Probable). Required for morphogenesis and function of the digestive tract.
messages: Nucleus
messages: RNAi-mediated knockdown results in defects in feeding, and failed growth and development eventually leading to lethality at the late L1 to L2 stage of larval development. Morphological defects in the digestive tract, such as enlarged pharyngeal intestinal valve lumen, leading to functional defects including accumulation of ingested bacteria in the lumen of the posterior intestine and defective elimination from the anterior lumen of the intestine.

6239:CELE F21F8.4
gene id: 6239:CELE_F21F8.4
uniprot id: O01531
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C37A5.9
gene id: 6239:CELE_C37A5.9
uniprot id: O62090
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in hypodermal cells (seam cells) V5 and V6, Q neuroblasts, ventral hypodermal cells P7/8 to P11/12, body wall muscle cells and neurons in the head, the tail and the ventral nerve cord.
messages: Expressed throughout development.
messages: Interacts (via N-terminus) with apr-1 (via C-terminus). Interacts with bar-1 (via ARM repeats), gsk-3, and mig-5.
messages: Nucleus
messages: Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.
messages: Worms exhibit ectopic rays and lack alae in V cells of the male tail. Mutants appear scrawny, often herniated, uncoordinated, show defects in dorsal and ventral cord fasciculation, commissure guidance defects, and over activated Wnt signaling pathway. Phenotypes are more penetrant in the pry-1 and axl-1 double mutant, suggesting some functional overlaps.
messages: cell cortex

6239:CELE C49H3.11
gene id: 6239:CELE_C49H3.11
uniprot id: P51403
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). In complex with ztf-7, mediates the cold-warm shock response by promoting translocation of components of the RNA exosome from the nucleolus to nucleoplasm (PubMed:36763670).
messages: Interacts with ztf-7.
messages: RNAi-mediated knockdown results in a significant reduction of the mRNA levels of ztf-7 and blocking cold-warm shock-induced exosome translocation from the nucleolus to nucleoplasm.

6239:CELE K08E5.2
gene id: 6239:CELE_K08E5.2
uniprot id: Q21339
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span.
messages: Membrane
messages: Nad-1 and nad-2 are coexpressed in the intestinal tract from early larvae to adults, expression is from the pharynx through to the anus. Expression level is significantly greater in the anterior half of the intestine than in the posterior half.
messages: Not detected in the embryo. Expressed at the early larval, late larval and adult stages, with highest levels at the late larval stage.

6239:CELE ZK1053.6
gene id: 6239:CELE_ZK1053.6
uniprot id: O02340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE T21F2.1
gene id: 6239:CELE_T21F2.1
uniprot id: H2KYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE K04C1.6
gene id: 6239:CELE_K04C1.6
uniprot id: G5EEF5
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y38C1AA.4
gene id: 6239:CELE_Y38C1AA.4
uniprot id: Q9N428
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: May act synergistically with the Wnt pathways to control T-cell fate specification, gonad development, and P12 cell fate specification. Required for the distribution of pop-1 and tlp-1 proteins.
messages: Nucleus
messages: Strongly expressed in the cytoplasm of the pharynx muscle cells and several head neurons, probably the IL1s or IL2s, throughout development. Also expressed in some other unidentified neurons in the tail region. Weakly expressed in the nuclei of the T-cells and the T-cell daughters. Not expressed in gonads and in P12 cell.

6239:CELE F26G1.7
gene id: 6239:CELE_F26G1.7
uniprot id: Q19832
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F16H11.3
gene id: 6239:CELE_F16H11.3
uniprot id: Q19495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE Y87G2A.2
gene id: 6239:CELE_Y87G2A.2
uniprot id: Q9U1Q5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE C30F12.1
gene id: 6239:CELE_C30F12.1
uniprot id: Q95YE2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZC3H12 family.
messages: Cytoplasm
messages: Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript (PubMed:27746047). Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes (PubMed:27746047). May play a role in the clearance of apoptotic cell corpses (PubMed:18425118).
messages: Expressed in the intestinal cells adjacent to the pharynx.
messages: Viable, but exhibit slower development and have reduced body fat (PubMed:27746047). RNAi-mediated knockdown results in increased sensitivity and reduced survival in response to lower temperatures (PubMed:27746047). RNAi-mediated knockdown results in increased expression of the transcription factor ets-4 in the nuclei of intestinal cells, which may further result in changes in the expression of genes involved in lipid metabolism (PubMed:27746047). RNAi-mediated knockdown also causes a defect in the clearance of apoptotic cell corpses in hermaphrodite gonads (PubMed:18425118).

6239:CELE F58E6.1
gene id: 6239:CELE_F58E6.1
uniprot id: Q20977
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription (By similarity). Required, in concert with transcription factor elt-3, for up-regulation of the vacuolar H(+)-ATPase and acceleration of lysosome maturation at molt (PubMed:31735670). As part of the innate immune response to molting and injury of the adult epidermis, positively regulates the expression of epidermal antimicrobial peptides, such as nlp-29 (PubMed:22470487, PubMed:21575913, PubMed:33259791). Through positively modulating the expression of epidermal antimicrobial peptides, such as nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (PubMed:22470487, PubMed:21575913). Functions cell autonomously in the epidermis, in concert with sodium-dependent transporter snf-12, probably acting at vesicular membranes, downstream of a p38 MAPK/pmk-1 pathway.
messages: Cytoplasm
messages: Expressed in the epidermis throughout development (PubMed:21575913). Also expressed in the seam cells, which are specialized epithelial cells that secrete the cuticle, as well as in the intestine, the phasmid socket cells, and the excretory duct cell, as well as cells in the vulva and the dorsal rectal cells (PubMed:21575913).
messages: Intron retention.
messages: May interact with sodium-dependent transporter snf-12; the interaction is probably direct.
messages: Nucleus
messages: RNAi-mediated knockdown almost completely abolishes induction of nlp-29 expression upon infection with Drechmeria coniospora, or upon injury, or in response to phorbol ester PMA.
messages: Vesicle

6239:CELE F45G2.5
gene id: 6239:CELE_F45G2.5
uniprot id: O62247
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Appears to have serine protease activity in vitro (PubMed:19716386). However, it is uncertain if this activity is genuine as bli-5 lacks all the catalytic features of serine proteases.
messages: Appears to lack serine protease inhibitor activity in vitro when tested with bovine pancreatic alpha-chymotrypsin and elastase (PubMed:19716386). Involved in cuticle biosynthesis (PubMed:16500660, PubMed:19716386).
messages: Expressed at low levels in larvae and adults. Expression increases during L2-L3 molting stage an prior L3-L4 molting stage.
messages: Expressed in larval and adult hypodermis, hermaphrodite vulva and adult excretory cell and duct.
messages: RNAi-mediated knockdown causes blisters in the cuticle and abnormal localization of collagen col-19 in cuticle dorso/ventral annulae and lateral alea.

6239:CELE R107.8
gene id: 6239:CELE_R107.8
uniprot id: P14585
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the NOTCH family.
messages: Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions (PubMed:3419531, PubMed:3000611). Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11 (PubMed:18036582, PubMed:18700817, PubMed:32053105, PubMed:3419531). Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes (PubMed:8343960, PubMed:7566091, PubMed:16197940, PubMed:10830967, PubMed:16530045, PubMed:18381292). Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells (PubMed:3419531, PubMed:18036582). Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10 (PubMed:9389650). Best known for involvement in cell-fate decisions during development, but also plays roles in other events (PubMed:10903169, PubMed:18599512, PubMed:21549604, PubMed:27661254). Regulates recovery from the dauer larval state (PubMed:18599512). Modulates chemosensory avoidance of octanol and quiescence during molting (PubMed:21549604). Promotes basement membrane mobility during tissue remodeling (PubMed:27661254). Involved in establishing left-right asymmetry during intestinal organogenesis (PubMed:10903169).
messages: Expressed in the postembryonic mesodermal lineage (M lineage) at the 4-M to 8-M stages, at similar levels in both the dorsal and the ventral sides (PubMed:18036582). At the 10-M stage and later, expression becomes more restricted along the anterioposterior axis and gradually lost in the anterior M lineage cells, but retained in the posterior M lineage cells (PubMed:18036582).
messages: May interact with dsl-1 (PubMed:18700817). May interact with lag-2 (PubMed:18700817). May interact with osm-11 (PubMed:18700817). Interacts with sel-10 (PubMed:9389650).
messages: Nucleus
messages: RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility (PubMed:27661254). Knockdown on a glp-1 mutant background impairs octanol response when animals are shifted to the restrictive temperature (PubMed:21549604).
messages: Upon binding its ligands, it is cleaved (S2 cleavage) in its extracellular domain, close to the transmembrane domain (By similarity). S2 cleavage is probably mediated by the metalloproteases adm-4 and sup-17 (PubMed:16197940). It is then cleaved (S3 cleavage) downstream of its transmembrane domain, releasing it from the cell membrane; S3 cleavage requires a multiprotein gamma-secretase complex, which may include presenilin sel-12 (PubMed:7566091).
messages: When activated, the lin-12/Notch intracellular domain (NICD) can become a component of a complex consisting of at least the NICD, lag-1 and sel-8/lag-3 (PubMed:16530045, PubMed:18381292). The NICD probably facilitates ordered assembly of the ternary complex via allosteric interactions of its RBP-j associated molecule (RAM) domain with lag-1 (PubMed:16530045, PubMed:18381292).

6239:CELE C08B11.8
gene id: 6239:CELE_C08B11.8
uniprot id: Q09226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation (By similarity). Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

6239:CELE Y43D4A.2
gene id: 6239:CELE_Y43D4A.2
uniprot id: Q9NF29
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F10G8.4
gene id: 6239:CELE_F10G8.4
uniprot id: G5EGU2
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the 2 embryonic head hypodermal cells XXXL/R.
messages: Its phosphatase activity is uncertain. Lacks in vitro phosphatase activity with p-nitrophenylphosphate, even if the catalytic Cys is conserved.
messages: Moderate increase in constitutive dauer larva formation at 27 degrees Celsius. Increases constitutive dauer larva formation at 25 degrees Celsius in akt-1 mg306, age-1 hx546 or pdk-1 sa709 mutant backgrounds. Normal lifespan.
messages: Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.

6239:CELE T13H5.8
gene id: 6239:CELE_T13H5.8
uniprot id: Q95QB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

6239:CELE F02C9.3
gene id: 6239:CELE_F02C9.3
uniprot id: P91203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

6239:CELE Y73B6BL.32
gene id: 6239:CELE_Y73B6BL.32
uniprot id: Q95XD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

6239:CELE C52D10.9
gene id: 6239:CELE_C52D10.9
uniprot id: G5ECY4
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE Y25C1A.8
gene id: 6239:CELE_Y25C1A.8
uniprot id: H2KYA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus

6239:CELE T03F7.1
gene id: 6239:CELE_T03F7.1
uniprot id: G5EF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

6239:CELE EEED8.5
gene id: 6239:CELE_EEED8.5
uniprot id: Q09530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
messages: Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes.
messages: Nucleus

6239:CELE Y59A8B.23
gene id: 6239:CELE_Y59A8B.23
uniprot id: G5EEN4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed at all stages.
messages: Hermaphrodites arrest after the first molt and die after at most 6 days. Most animals appear L2-like with morphologies of gonads and vulva that are out of step with the developmental stage. Mutants have a dilated intestinal lumen with extensive internal folding associated with the accumulation of undigested bacteria and a shortened excretory canal. Some animals have adult-type alae and are sterile with vulva and germ line formation defects (PubMed:20595048). In RNAi-mediated knockdown, impaired survival and slower volume recovery upon hypertonic stress (PubMed:17596296).
messages: Interacts (via C-terminus) with clh-3; required for the phosphorylation-mediated inhibition of clh-3 function (PubMed:15684092). Interacts (via C-terminus) with wnk-1; the interaction is direct (PubMed:17596296, PubMed:18049475).
messages: Nucleus
messages: Phosphorylated at Thr-280 and Ser-419 probably by wnk-1; phosphorylation results in weak activation (PubMed:18049475). Predominantly autophosphorylated at Thr-32 and Ser-190 and weakly autophosphorylated at Thr-13 and Ser-405 in vitro (PubMed:20595048).
messages: Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation-mediated inhibition of the chloride channel clh-3 (PubMed:15684092, PubMed:17596296). In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1 (PubMed:23076791). Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages (PubMed:20595048). In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. By controlling clh-3 activity, may regulate the development of the excretory canals and fertility (PubMed:18049475).
messages: Ubiquitously expressed with a higher expression in the excretory cell. Expressed in both male and female germ cells; up-regulated in maturing spermatocytes but absent in mature sperm.

6239:CELE C33H5.14
gene id: 6239:CELE_C33H5.14
uniprot id: Q18411
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Golgi apparatus membrane
messages: In contrast to uda-1, expression is not induced by stress.
messages: Seems to be able to hydrolyze CTP, ATP and UTP.

6239:CELE C14A11.1
gene id: 6239:CELE_C14A11.1
uniprot id: G4RWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE ZK354.11
gene id: 6239:CELE_ZK354.11
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C27B7.1
gene id: 6239:CELE_C27B7.1
uniprot id: Q18240
uniprot id: Q7JMA9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nucleosome assembly protein (NAP) family.
messages: Loss of function results in a suppression of sel-12 mutant phenotypes, possibly by up-regulating hop-1 expression.
messages: Nucleus
messages: Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1.
messages: Widely expressed.

6239:CELE W09C5.4
gene id: 6239:CELE_W09C5.4
uniprot id: Q9U333
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE Y87G2A.18
gene id: 6239:CELE_Y87G2A.18
uniprot id: Q7YXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE R08B4.3
gene id: 6239:CELE_R08B4.3
uniprot id: Q9XVW5
names: Similarity
messages: Belongs to the yippee family.

6239:CELE B0350.2
gene id: 6239:CELE_B0350.2
uniprot id: Q5TYL5
uniprot id: Q5TYL6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F15G9.5
gene id: 6239:CELE_F15G9.5
uniprot id: Q10037
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58A4.11
gene id: 6239:CELE_F58A4.11
uniprot id: P34478
names: Disruption Phenotype
names: Subunit
messages: Interacts with gex-3.
messages: No visible phenotype.

6239:CELE F41C3.5
gene id: 6239:CELE_F41C3.5
uniprot id: P52717
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE Y39G8C.1
gene id: 6239:CELE_Y39G8C.1
uniprot id: Q9BHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

6239:CELE Y39A3CR.4
gene id: 6239:CELE_Y39A3CR.4
uniprot id: Q9N408
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of ddp-1/tim-8 and 3 copies of tin-13/tim-13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim-22.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane (By similarity). Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane (By similarity). Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). The ddp-1/tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (PubMed:15485840).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of ddp-1/tim-8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
messages: Worms display mitochondria with an interconnected morphology, presumably due to defects in the assembly of outer membrane fission/fusion components.

6239:CELE F54H5.4
gene id: 6239:CELE_F54H5.4
uniprot id: Q65ZG6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed throughout development, including in the germline and especially in intestine in larval and adult stages (at protein level).
messages: Expression is repressed in response to high levels of dietary calcium.
messages: Nucleus
messages: Probable transcription factor which regulates lipid catabolism, storage, and secretion, probably by modulating genes involved in fatty acid desaturation and beta-oxidation, and lipoprotein assembly and secretion (PubMed:19427851, PubMed:23639358). Involved in reproduction, perhaps indirectly (PubMed:19427851, PubMed:23639358).

6239:CELE F54F3.1
gene id: 6239:CELE_F54F3.1
uniprot id: C7FZU3
uniprot id: C7FZU4
uniprot id: Q93791
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

6239:CELE D1009.1
gene id: 6239:CELE_D1009.1
uniprot id: A0A131MB92
uniprot id: Q18916
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F55D12.4
gene id: 6239:CELE_F55D12.4
uniprot id: G5ECR9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in spicule protractor and retractor muscles, and the male-specific neuron CP9 (PubMed:18652814). Expressed in the nerve ring, and preanal ganglion (PubMed:9852581). Expressed in asymmetric motor neurons (PubMed:9852581, PubMed:29033363). Expressed in ventral D motor neurons (PubMed:9852581, PubMed:7869081, PubMed:15882588, PubMed:29033363). Isoform a: Expressed in males and hermaphrodites (PubMed:18652814). Isoform b: Only expressed in males (PubMed:18652814).
messages: Expression in the asymmetric and ventral D motor neurons in the ventral nerve cord is restricted to the postembryonic stages L2 and L3.
messages: Nucleus
messages: Required for normal locomotion.
messages: Transcription factor (PubMed:28056346, PubMed:29033363). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factors unc-3 or irx-1 in subsets of motor neurons (PubMed:28056346, PubMed:22031882). Probably acts by binding to specific promoter elements (PubMed:28056346). Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern (PubMed:7869081, PubMed:22031882). Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern (PubMed:15882588). Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation (PubMed:29033363). This prevents respecification of synapses by VD neurons (PubMed:29033363). During copulation, required in males for correct movement of the spicules, a pair of prong-like structures which are inserted into the vulva of the hermaphrodite and anchor the male to the hermaphrodite (PubMed:18652814). Required for spicule prodding which allows detection of the vulva location and for spicule insertion into the vulva (PubMed:18652814).

6239:CELE F27E11.1
gene id: 6239:CELE_F27E11.1
uniprot id: G5EE77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

6239:CELE F53B6.1
gene id: 6239:CELE_F53B6.1
uniprot id: Q9XVM9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Embryonic lethal (PubMed:23028364). Mutants display dumpy and blistered cuticle phenotypes (PubMed:23028364). Blisters contain unidentified cellular material (PubMed:23028364, PubMed:25480962). Resistant to iodide toxicity (PubMed:25480962). RNAi-mediated knockdown results in the lethality of more than 95% of progeny at the larval stage (PubMed:15454573). Most larval arrest occurs at the L4 larval stage and is characterized by body swelling and abnormal epidermal morphology, which includes blistering of the cuticle (PubMed:15454573, PubMed:25480962). The few animals that develop into adults have a distended body shape and/or epidermal blistering (PubMed:15454573). Abnormal cuticular and hypodermal morphology including splits in the cortical layer of the cuticle, abnormal gaps between the hypodermis and musculature and inconsistent thickness of the hypodermis (PubMed:15454573, PubMed:25480962). Impaired hypodermal membrane integrity and reduced fibrous organelles (PubMed:15454573).
messages: Expressed in cells along the anteroposterior axis from the 1.5-fold stage of embryogenesis until the 3-fold stage when expression decreases but increases in the body surface with prominent expression in the lateral hypodermal cells (PubMed:23028364, PubMed:15454573). Expressed in the pharynx and body wall from the larval stage to adulthood.
messages: Expressed in the body wall (hyp7 hypodermal syncitium), pharynx and vulva. Expressed in a punctate pattern along the thick region of the hypodermis.
messages: Interacts with doxa-1 and bli-3.
messages: Membrane
messages: Plays a role in cuticle biogenesis (PubMed:15454573, PubMed:23028364, PubMed:25480962). In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix (PubMed:23028364).

6239:CELE M18.8
gene id: 6239:CELE_M18.8
uniprot id: G5EFD8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE C44C10.1
gene id: 6239:CELE_C44C10.1
uniprot id: Q18620
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZK84.7
gene id: 6239:CELE_ZK84.7
uniprot id: Q7JPJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F58F6.2
gene id: 6239:CELE_F58F6.2
uniprot id: O44173
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F35B3.5
gene id: 6239:CELE_F35B3.5
uniprot id: U4PAZ9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CAMSAP1 family.
messages: Expressed in larval and adult epidermis, intestine and pharynx (PubMed:26371552). Broadly expressed in the nervous system (PubMed:24569480, PubMed:26371552). Expressed in body wall muscle cells (PubMed:24569477).
messages: Expressed throughout development (PubMed:24569477). Expressed in stretches and puncta in the body syncytium and in puncta within seam cells (PubMed:26371552).
messages: Interacts with dapk-1.
messages: Perikaryon
messages: Required for microtubule stability and anchorage by binding to the minus ends of microtubules (PubMed:25437544, PubMed:26371552, PubMed:27661253). Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis (PubMed:26371552). Promotes microtubule stability and polymerization in neurons (PubMed:24569477). Involved in the maintenance of neurite morphology in ALM and PLM neurons (PubMed:25437544, PubMed:24569477, PubMed:24569480). May play a role in synaptic protein localization in the PLM neuron (PubMed:24569477). May act upstream of dlk-1 in neuronal regeneration (PubMed:25437544, PubMed:24569480). Plays a role in postembryonic epidermal tissue integrity and wound healing (PubMed:27661253).
messages: The CKK domain binds microtubules. Might be required for microtubule stabilization (PubMed:27661253).
messages: The Calponin-homology (CH) domain might negatively regulate the CKK domain.
messages: The coiled-coil domain contributes to microtubule binding and might negatively regulate the CKK domain.
messages: Viable with no gross morphological defects, but exhibit uncoordinated locomotion and body positioning (PubMed:24569477, PubMed:24569480, PubMed:26371552). Small reduction in the density of microtubule bundles along the length of the body (PubMed:25437544, PubMed:26371552). Fewer microtubules in the axons of PLM and ALM neurons (PubMed:25437544, PubMed:24569477). Defective touch neuron morphology with ectopic neurites extending from the cell bodies of ALM neurons (PubMed:25437544). Irregular PLM neuron morphology including defective PLM neuron commissure extension, loss of collateral branches, presynaptic varicosities, overextended neurites and abnormal synapse localization as identified by lack of small GTPase rab-3 and snb-1 at synaptic patches (PubMed:24569477, PubMed:24569480). Impaired PLM neuron regeneration following severing of the PLM axon (PubMed:25437544). Loss of circumferential microtubule bundles and shortening of remaining bundles (PubMed:27661253). Increased microtubule growth rates (PubMed:27661253). Delayed wound closure (PubMed:27661253). Treatment with a microtubule stabilizing drug, paclitaxel, results in epidermal morphology defects (PubMed:27661253). Treatment with a microtubule destabilizing drug, colchicine, results in loss of light touch sensitivity and ectopic sprouting from neuronal axons (PubMed:24569477). Double knockout with noca-1 isoforms results in severe developmental defects with 60% not surviving beyond early postembryonic stages, mainly dying at the larval developmental stage L4, and slow growth with surviving mutants being smaller in size and uncoordinated (PubMed:26371552). Double mutants also have significantly fewer microtubule bundles along the length of the body, broken or branched seam cell syncytia that is disconnected from the head and the cuticles have increased permeability (PubMed:26371552). In a dapk-1 mutant background, suppression of the epidermal morphology defects (PubMed:27661253).
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite
messages: sarcolemma

6239:CELE C36B1.8
gene id: 6239:CELE_C36B1.8
uniprot id: Q8I4M5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed both maternally and zygotically throughout development and in adult hermaphrodites (at protein level).
messages: Expressed in the germline (at protein level). In the early embryo is expressed in all cells, then becomes gradually restricted to the germ cell lineage and enriches in P granules (at protein level). In adult hermaphrodites, is expressed in the mitotic region, accumulates during early stages of meiotic prophase I and is slightly less abundant in maturing oocytes (at protein level).
messages: Isoform C interacts (via C-terminus) with gld-3 isoform A (via C-terminus) in an RNA-independent manner. Isoform C interacts with gld-4.
messages: Loss of maternal and zygotic expression causes germline survival defects. Zygotic mutants show a masculinized hermaphrodite germline. At 25 degress Celsius, hermaphrodite zygotic mutants show small oogenic cells that are either arrested in pachytene or have undergone abnormal meiotic prophase progression and failed to arrest in diakinesis, often resulting in endoreduplicating oocyte nuclei.
messages: Required maternally for germline survival by forming a maternal complex with gld-3. During hermaphrodite development forms a complex with gld-3 which promotes the sperm/oocyte switch freeing the translational repressor fbf to turn off sperm promoting factors. Required for proper oocyte differentiation and oogenic meiotic arrest. Stimulates the enzymatic activity of gld-4 and together they prevent gld-1 mRNA degradation.
messages: Trans-spliced exclusively to SL2, suggesting a transcriptional coregulation with the upstream gene dhfr-1.

6239:CELE Y105C5B.13
gene id: 6239:CELE_Y105C5B.13
uniprot id: G5EG39
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE F22B5.9
gene id: 6239:CELE_F22B5.9
uniprot id: Q19713
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

6239:CELE Y48E1B.1
gene id: 6239:CELE_Y48E1B.1
uniprot id: O18195
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). Acts as a component of the DHIC (ddl-1-containing hsf-1 inhibitory complex) which modulates lifespan by sequestering the heat shock transcription factor hsf-1 to negatively regulate its binding to DNA and its transcriptional activity (PubMed:22265419).
messages: Belongs to the WASH1 family.
messages: Component of the WASH core complex (By similarity). Component of the DHIC (ddl-1-containing hsf-1 inhibitory) complex, which contains at least ddl-1, ddl-2, hsb-1 and hsf-1 (PubMed:22265419). Within the complex, interacts with ddl-1 (PubMed:22265419). Formation of the DHIC may be dependent upon the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:22265419).
messages: Expressed in several neurons located throughout the body.
messages: RNAi-mediated knockdown positively modulates lifespan; effect abolished in hsf-1 mutant background (PubMed:22265419). Increases resistance to both heat and oxidative stresses (PubMed:22265419). Increases localization to the nucleus and also DNA binding activity of heat-shock transcription factor hsf-1 after heat shock (PubMed:22265419). Increases in transcript levels of heat shock protein genes sim-1, hsp-70, hsp-16.2 and F44E5.5 after heat shock, but not in unstressed conditions (PubMed:22265419). May also moderately decrease levels of post-translationally modified hsf-1 under heat stressed conditions (PubMed:22265419).

6239:CELE F32E10.4
gene id: 6239:CELE_F32E10.4
uniprot id: Q19969
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin alpha family.
messages: Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:11311162). Promotes docking of import substrates to the nuclear envelope (PubMed:11311162). Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (PubMed:11311162). Necessary for correct nucleoporin localization within the germline (PubMed:11311162). Essential gene for embryonic and larval development (PubMed:11311162). May be dispensable for axon development, but required for axon regeneration in both mechanosensory and motor neurons (PubMed:31417366). Required for oogenic development, ima-1 and ima-2 cannot functionally compensate for loss of ima-3 (PubMed:11311162).
messages: Cytoplasm
messages: Expressed at high levels throughout all developmental stages.
messages: Expressed in larval and adult germline and somatic tissues, including neurons.
messages: Forms a complex with an importin beta subunit (PubMed:11311162). May interact with transcription factor cebp-1 (via N-terminus) (PubMed:31417366).
messages: Larval lethality (PubMed:31417366). Mechanosensory neurons are born and develop normally (PubMed:31417366). However, cre-mediated knockdown targeted to mechanosensory neurons severely impairs axon regrowth of mechanosensory PLM neurons after injury (PubMed:31417366).
messages: Nucleus

6239:CELE C56C10.8
gene id: 6239:CELE_C56C10.8
uniprot id: Q18885
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Expressed throughout development.
messages: May be a general transcription factor that can form a stable complex with RNA polymerase II (By similarity). May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity). In response to heat stress, plays a role in modulating the unfolded protein response by negatively regulating the accumulation of proteins such as the chaperone protein hsp-4 in the endoplasmic reticulum (PubMed:22957041). Required to suppress apoptosis in neuronal and intestinal cells to promote development (PubMed:12944970).
messages: May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).
messages: Mitochondrion
messages: Nucleus
messages: RNAi-mediated knockdown mostly results in embryonic lethality, but embryos that do hatch produce larvae with a large number of apoptotic cell corpses, which are first present at the comma stage of development (PubMed:12944970). Surviving animals are uncoordinated (PubMed:12944970). RNAi-mediated knockdown results in increased neuronal and intestinal cell death and a reduced number of male tail rays in larvae (PubMed:12944970). RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type (PubMed:22957041). RNAi-mediated knockdown in adults results in embryos with severe morphological defects and high numbers of enlarged bi-refringent lipofuscin glo-1-positive granules in their gut cells, and increased cell death and degeneration (PubMed:22957041). These embryos also have increased expression of the endoplasmic reticulum-specific chaperone protein hsp-4 in regions of the embryo that contain gut and epithelial cells (PubMed:22957041).

6239:CELE R09B3.4
gene id: 6239:CELE_R09B3.4
uniprot id: Q9XVK5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins (PubMed:10993680). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
messages: Cytoplasm
messages: Expressed throughout development (PubMed:10993680). Highly expressed in hyp10 tail tip cells in early L4 larval stage males (PubMed:21408209). Expressed in hyp10 tail tip cells prior to and during male tail tip retraction (PubMed:21408209).
messages: Worms either arrest during embryonic development, or show vulval eversion at the L4 stage and burst at the vulva during the L4-to-adult molt (PubMed:10993680). Those who survive to the adult stage display severe abnormalities in the structure of alae (PubMed:10993680). RNAi-mediated knockdown results in severe male tail tip defects (PubMed:21408209).

6239:CELE F44E5.4
gene id: 6239:CELE_F44E5.4
uniprot id: G5ECU5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE C09E7.3
gene id: 6239:CELE_C09E7.3
uniprot id: Q9N5Z2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in DD and VD GABAergic motor neurons (PubMed:26387713, PubMed:26083757). Expressed in a subset of head neurons including M2 motor neurons in the pharynx (PubMed:26387713, PubMed:26083757). Expressed in coelomocytes (PubMed:26387713).
messages: Membrane
messages: Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons (PubMed:26387713, PubMed:26083757). Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr-12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation (PubMed:26387713).
messages: Transiently expressed in DD GABAergic motor neurons in embryos and during larval stage L1, with expression decreasing as development proceeds (PubMed:26387713, PubMed:26083757). Expressed strongly in VD GABAergic motor neurons from the end of larval stage L1 onwards and in particular along the ventral nerve cord (PubMed:26387713, PubMed:26083757). Specifically expressed in DD GABAergic motor neurons in the dorsal and ventral nerve cords at larval stages L1 and L4 (PubMed:26387713).
messages: Viable with locomotory defects which may be attributed to impaired GABAergic motor neuron function (PubMed:26387713, PubMed:26083757). Hypersensitive to the drug aldicarb which may be indicative of abnormal GABAergic signaling (PubMed:26083757). Premature postsynaptic remodeling/formation of DD GABAergic motor neurons in animals at larval stage L1 with remodeling/formation occurring 8-16 hours posthatching as opposed to 14-18 hours posthatching in wild-type animals (PubMed:26387713). Mislocalization of postsynaptic proteins with increased dorsal to ventral translocation of the acr-12 receptor in VD GABAergic motor neurons at larval stages L2 and L4; leading to no acr-12 puncta in the dorsal nerve and probably contributing to improper formation of synaptic inputs and ectopic postsynaptic remodeling/formation of VD motor neurons (PubMed:26387713, PubMed:26083757). Abnormal ectopic clustering of the postsynaptic receptor unc-49 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Abnormal clustering of the presynaptic proteins snb-1 and rab-3 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Additionally, aberrant localization of presynaptic proteins in VD GABAergic motor neurons with increased puncta for presynaptic proteins including snb-1, rab-3 and syd-2 in the dorsal nerve cord, but fewer puncta in the ventral nerve cord at larval stages proceeding the L1 larval stage, probably indicative of impaired and ectopic presynaptic remodeling/formation (PubMed:26387713, PubMed:26083757).
messages: axon
messages: dendrite
messages: extracellular space

6239:CELE T26A5.1
gene id: 6239:CELE_T26A5.1
uniprot id: Q22802
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE K12H4.8
gene id: 6239:CELE_K12H4.8
uniprot id: P34529
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Component of the ERI/DICER complex at least composed of dcr-1, rrf-3 and eri-1 (Probable). Interacts with pir-1 (PubMed:16439208, PubMed:33378643).
messages: Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307). Involved in innate immunity through its role in small RNA processing.
messages: RNAi-mediated knockdown in a cps-6 mutant background reduces the number of DNA breaks in embryonic cells undergoing apoptosis.
messages: The avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never been exposed to this pathogenic bacteria.
messages: tDCR-1 acts as a deoxyribonuclease (DNase) initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2 and nuc-1.

6239:CELE T19E7.2
gene id: 6239:CELE_T19E7.2
uniprot id: P34707
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternative DNA-binding strategy due to lack of a leucine zipper dimerization segment: DNA binding domain binds to its cognate half-site, an N-terminal arm recognizes adjacent 5' AT-rich sequences in the minor groove and the intervening residues stabilize interactions of these two subdomains with DNA.
messages: Belongs to the bZIP family. Skn1 subfamily.
messages: Cleaved by the aspartic protease ddi-1.
messages: Cytoplasm
messages: Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.
messages: Expressed both maternally and zygotically.
messages: Interacts with pgma-5 (PubMed:23040073). Interacts with transcription factor mxl-3 (via N-terminus) (PubMed:23040073).
messages: Mitochondrion
messages: Monomer (PubMed:7939715). Interacts with GATA factor elt-3; interaction may enhance transcriptional activation of target genes (PubMed:28600327).
messages: Nucleus
messages: Postembryonic intestinal cells.
messages: RNAi-mediated knockdown decreases gst-4 mRNA expression in a brap-2 mutant background.
messages: RNAi-mediated knockdown of all isoforms results in a severe reduction in transcription of gst-4, gst-5, gst-7 and gcs-1 mRNAs during infection by P.aeruginosa or P.faecalis (PubMed:22216003). Susceptibility to P.aeruginosa and P.faecalis is characterized by a decrease in survival rate (PubMed:22216003).
messages: Transcription factor (PubMed:1547503, PubMed:28600327). Required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine (PubMed:1547503). Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development (PubMed:1547503, PubMed:11463373). In response to oxidative stress and anoxia, required to up-regulate expression of stl-1 mRNA (PubMed:24385935). Involved in regulating innate immunity, acting downstream of the pmk-1 p38/MAPK pathway and probably also downstream of nipi-3 (PubMed:34407394). Required for the up-regulation of phase II detoxification genes, including gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection (PubMed:22216003). Modulates oxidative stress responses in concert with transcription factors such as hcf-1 and elt-3 (PubMed:22568582, PubMed:28600327). Regulates the transcription of genes associated with metabolism in response to changes in nutrient availability (PubMed:23040073). In neurons, involved in mitochondrial fusion and behavioral recovery during reoxygenation (PubMed:24385935). Required for riok-1 mRNA expression in the intestine (PubMed:25688864). Downstream of the let-60/Ras, mek-2 and pmk-1 pathway, positively regulates lifespan probably by preventing transcription of insulin-like peptides such as ins-39 (PubMed:20624915). Prevents degeneration of dopaminergic CEP neurons in response to high Al(3+) or Mn(2+) levels, probably by promoting the expression of glutathione-S-transferase gst-1 (PubMed:23106139, PubMed:23721876).
messages: Viable, but there is failed activation of the expression of the proteasomal subunit rpt-3 in all tissues (PubMed:27528192). Treatment with the proteasome inhibitor bortezomib or knockout with rpn-10 RNAi results in larval lethality (PubMed:27528192). Double knockout with pbs-5 results in failed expression the proteasomal subunit rpt-3 (PubMed:27528192). Also causes a loss of transcription of riok-1 mRNA in intestine (PubMed:25688864). Reduces life span (PubMed:20624915). Moderate increase in transcription of ins-39 mRNA (PubMed:20624915). Moderate increase in CEP neuron death in response to high Al(3+) levels (PubMed:23106139). RNAi-mediated knockdown causes an increase in Mn(2+)-mediated dopaminergic CEP neuron degeneration and a reduction in expression levels of glutathione S-transferase gst-1 (PubMed:23721876).

6239:CELE F19F10.5
gene id: 6239:CELE_F19F10.5
uniprot id: O01519
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Probable transcription factor (By similarity). Involved in responses to oxidative stress (PubMed:27514077).
messages: Up-regulated by salicylamine.

6239:CELE T27B7.3
gene id: 6239:CELE_T27B7.3
uniprot id: O16661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C03E10.4
gene id: 6239:CELE_C03E10.4
uniprot id: O17560
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE B0432.2
gene id: 6239:CELE_B0432.2
uniprot id: P90994
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C56 family.
messages: Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death.
messages: Cytoplasm
messages: Expressed exclusively in the intestine.
messages: Nucleus

6239:CELE C39B10.6
gene id: 6239:CELE_C39B10.6
uniprot id: Q8MQA7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed at the 1.5-fold stage of embryogenesis and by the 3-fold stage, in all cells of the gut (PubMed:14573471). Expressed in nine cells in the posterior bulb of the pharynx from the 3-fold stage (PubMed:14573471). Expressed in the intestine at all stages of development (PubMed:14573471).
messages: No phenotype detected and so may be dispensable (PubMed:14573471). RNAi-mediated knockdown causes intestinal expression of heme transporter hrg-1 induced by heme to be reduced drastically in L3 stage larvae (PubMed:20938051). Reduces expression of the daf-16 isoforms d and f (PubMed:24834345).
messages: Nucleus
messages: Probable transcription factor (PubMed:20938051, PubMed:24834345). Plays a role in regulating heme-dependent expression of heme transporter hrg-1 (PubMed:20938051). Modulates lifespan in a daf-16-dependent manner (PubMed:24834345).

6239:CELE Y61A9LA.10
gene id: 6239:CELE_Y61A9LA.10
uniprot id: Q9N306
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE T20D3.7
gene id: 6239:CELE_T20D3.7
uniprot id: B3GWB9
uniprot id: L8E917
uniprot id: O01258
names: Function
names: Similarity
messages: Belongs to the VPS26 family.
messages: May play a role in vesicular protein sorting, similar to the yeast retromer proteins.

6239:CELE R09E10.3
gene id: 6239:CELE_R09E10.3
uniprot id: Q21872
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

6239:CELE F59C6.2
gene id: 6239:CELE_F59C6.2
uniprot id: Q93828
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F52B10.1
gene id: 6239:CELE_F52B10.1
uniprot id: Q20641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

6239:CELE F02A9.6
gene id: 6239:CELE_F02A9.6
uniprot id: P13508
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts on ABp development during 4-cell and 12-cell stages, and on ABa development during 12-cell and 28-cell stages (PubMed:8156602). Expressed in various neurons, including AWC, during the dauer larval stage (PubMed:18599512).
messages: Cell membrane
messages: Essential signaling protein which has a major role in germline and embryonic development; involved in cell fate decisions that require cell-cell interactions (PubMed:8156602, PubMed:16319922, PubMed:19379690). Probable membrane-bound receptor for putative ligands lag-2 and apx-1 (PubMed:8156602, PubMed:7607081). Upon ligand activation, and releasing from the cell membrane, the glp-1/Notch intracellular domain (NICD) probably forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes; targets in the germline include lst-1 and sygl-1 (PubMed:9003776, PubMed:10884418, PubMed:16319922, PubMed:32196486, PubMed:16197940, PubMed:7566091, PubMed:19379690). Involved in the specification of the cell fates of the blastomeres, ABa and ABp (PubMed:8156602). Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and ABp descendants to adopt a different fate (PubMed:8156602). Contributes to the establishment of the dorsal-ventral axis in early embryos (PubMed:8156602). Required in postmitotic neurons in order to maintain the developmentally arrested larval state known as dauer, probably in response to lag-2 (PubMed:18599512). Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression (PubMed:16319922, PubMed:22278922). Required for oocyte growth control (PubMed:19502484). Plays a negative role in lifespan (PubMed:21906946, PubMed:24332851, PubMed:28853436).
messages: Expressed in the distal mitotic region of the germ line (PubMed:7607081). May be absent from the gonadal distal tip cell (DTC) (PubMed:7607081).
messages: Interacts with sel-10.
messages: Nucleus
messages: RNAi-mediated knockdown causes an increase in lifespan and a moderate increase in aak-2 phosphorylation (PubMed:24332851). RNAi-mediated knockdown in a rsks-1 mutant background reduces the formation of proximal germ cell tumors (PubMed:22278922). RNAi-mediated knockdown results in abnormally large oocytes (PubMed:19502484).
messages: Upon binding its ligands, it is cleaved (S2 cleavage) in its extracellular domain, close to the transmembrane domain (By similarity). S2 cleavage is probably mediated by the metalloproteases adm-4 and sup-17 (PubMed:16197940). It is then cleaved (S3 cleavage) downstream of its transmembrane domain, releasing it from the cell membrane; S3 cleavage requires a multiprotein gamma-secretase complex, which may include presenilin sel-12 (PubMed:7566091).
messages: When activated, the glp-1/Notch intracellular domain (NICD) may become a component of a complex consisting of at least the NICD, lag-1 and lag-3.
messages: axon

6239:CELE M01A12.1
gene id: 6239:CELE_M01A12.1
uniprot id: E5QCF2
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE T10E10.7
gene id: 6239:CELE_T10E10.7
uniprot id: Q86NE2
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C05D11.10
gene id: 6239:CELE_C05D11.10
uniprot id: Q11189
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE K08B5.1
gene id: 6239:CELE_K08B5.1
uniprot id: Q21309
names: Subcellular Location Annotation
messages: Membrane

6239:CELE DY3.6
gene id: 6239:CELE_DY3.6
uniprot id: O45323
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y40D12A.2
gene id: 6239:CELE_Y40D12A.2
uniprot id: O76725
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE Y77E11A.10
gene id: 6239:CELE_Y77E11A.10
uniprot id: Q9N4B2
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE F45E12.2
gene id: 6239:CELE_F45E12.2
uniprot id: A0A131MBG0
uniprot id: A0A131MCT5
names: Similarity
messages: Belongs to the TFIIB family.

6239:CELE Y2H9A.2
gene id: 6239:CELE_Y2H9A.2
uniprot id: Q9U2P4
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE R08F11.3
gene id: 6239:CELE_R08F11.3
uniprot id: O02641
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F52F12.1
gene id: 6239:CELE_F52F12.1
uniprot id: Q9U539
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Transports organic cations such as tetraethylammonium (TEA). Displays a broad substrate specificity.

6239:CELE W02B12.12
gene id: 6239:CELE_W02B12.12
uniprot id: Q23128
uniprot id: Q6A4Q6
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C26G2.1
gene id: 6239:CELE_C26G2.1
uniprot id: Q9U3P2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are viable, fertile, egg-laying proficient and coordinated. Abnormal synaptic vesicle clustering in the HSNL motor neuron from larval stage L3 through to adulthood. Reduced accumulation of synaptic vesicle proteins snb-1 and cat-1 in HSNL motor neuron. Defective synapse specificity due to altered distribution of synapses. syg-1 is mis-localized and diffusely distributed on the axon of the HSNL neuron.
messages: Cell adhesion protein (PubMed:15035988). Determines synapse formation (PubMed:15035988, PubMed:21858180, PubMed:24485456). Required for correct localization of syg-1 at synaptic sites (PubMed:15035988).
messages: Cell membrane
messages: Expressed in head neurons and body wall muscles during embryogenesis (PubMed:15035988). Expressed in head and body wall muscles and in punctate structures near the ventral nerve cord during larval stages L1 and L2 (PubMed:15035988). Expressed in primary vulval epithelial cells from larval stage L3, with expression increasing upon entry into L4 and diminished within six hours of adulthood (PubMed:15035988, PubMed:18675916).
messages: Expressed in vulval epithelial cells.
messages: Interacts with syg-1.
messages: Synapse
messages: The cytoplasmic domain is necessary for syg-2 subcellular localization.
messages: The first five extracellular Ig-like domains are required for correct localization of syg-1.

6239:CELE F10C5.1
gene id: 6239:CELE_F10C5.1
uniprot id: Q19294
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC8/CDC23 family.
messages: Developmental defects in the gonad, germline, male tail and hermaphrodite vulva (PubMed:15238519). Increased number of germ cells arrested at the metaphase stage of mitosis during the larval stage L4; by adulthood, there are no nuclei in the distal part of the gonad and as a result, no sperm or oocytes are formed (PubMed:15238519). RNAi-mediated knockdown results in defective metaphase to anaphase transition (Mat phenotype) and embryos that arrest at the one-cell stage that display defects in the formation of the anterior-posterior axis (PubMed:11861581, PubMed:11832245).
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581, PubMed:15238519). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076, PubMed:11861581, PubMed:15238519). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE C27A12.9
gene id: 6239:CELE_C27A12.9
uniprot id: O01966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F16H6.3
gene id: 6239:CELE_F16H6.3
uniprot id: Q9XV90
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F01G4.6
gene id: 6239:CELE_F01G4.6
uniprot id: G5ECU3
uniprot id: P40614
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Transport of phosphate groups from the cytosol to the mitochondrial matrix.

6239:CELE F48D6.1
gene id: 6239:CELE_F48D6.1
uniprot id: Q20563
names: Similarity
messages: Belongs to the TAF11 family.

6239:CELE T28D9.10
gene id: 6239:CELE_T28D9.10
uniprot id: Q10013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

6239:CELE K07C11.4
gene id: 6239:CELE_K07C11.4
uniprot id: Q21266
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE Y49E10.1
gene id: 6239:CELE_Y49E10.1
uniprot id: Q9XTT9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex (Probable). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts with elt-2 (PubMed:30265660).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:30265660). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:30265660). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides (By similarity). In addition, regulates gene expression in response to bacterial infection (PubMed:30265660). Binds to the GATA transcription factor elt-2 to control its transcriptional activity and thus the expression of elt-2-dependent genes in response to infection by Gram-negative bacteria such as P.aeruginosa (PubMed:30265660).
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown at the L4 stage of larval development inhibits activity of the proteasome (PubMed:30265660). RNAi-mediated knockdown at the L4 larval stage also results in increased mortality and transcription of immune genes containing the elt-2 binding motif when exposed to Gram-negative bacteria such as P.aeruginosa (PubMed:30265660). RNAi-mediated knockdown at this stage, furthermore, prevents the recovery of P.aeruginosa infected animals treated with the antibiotic streptomycin (PubMed:30265660).

6239:CELE AH6.11
gene id: 6239:CELE_AH6.11
uniprot id: Q09209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE ZK524.2
gene id: 6239:CELE_ZK524.2
uniprot id: P27715
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the unc-13 family.
messages: Interacts with cmd-1 in the presence of Ca(2+).
messages: May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions (PubMed:2062851). One such function could be the release of neurotransmitter from neurons (PubMed:2062851). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt, (PubMed:17891142).
messages: The phorbol ester binding activity is zinc and calcium-dependent.
messages: Worms exhibit diverse nervous system defects.

6239:CELE Y111B2A.1
gene id: 6239:CELE_Y111B2A.1
uniprot id: Q9BHM0
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE K03C7.2
gene id: 6239:CELE_K03C7.2
uniprot id: Q21187
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in mechanosensory neurons.
messages: Expressed in neurons and intestinal cells in L2 stage larvae.
messages: Nucleus
messages: RNAi-mediated knockdown severely impairs axon regeneration in a daf-2 mutant background, in a daf-16-dependent-manner (PubMed:26675724). Impairs short-term associative memory in a daf-2 mutant background in a daf-16-dependent-manner (PubMed:26675724). Reduces longevity in a daf-2 mutant background (PubMed:26675724).
messages: Transcription factor (PubMed:26963674). Binds to the regulatory elements of genes that contain the sequence motif 5'-TTGTTTCT-3' (PubMed:26963674). Involved in regulating intestinal transcription of vitellogenin vit-2, acting in concert with transcription factors elt-2, mab-3 and daf-16, and also the TGF-beta/Sma/Mab pathway (PubMed:26963674). Functions downstream of the insulin/IGF-1-like signaling (IIS) mediated pathway, in regeneration of axons after injury and in short-term memory, perhaps acting in neurons, and in modulation of longevity, perhaps acting non-neuronally (PubMed:26675724). Plays a role in the modulation of endoplasmic reticulum (ER) homeostasis during chemical and pathogen stress, including exposure to the Gram-negative bacterium P.aeruginosa (PubMed:30287474).

6239:CELE M03F8.4
gene id: 6239:CELE_M03F8.4
uniprot id: O16374
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 92 family.
messages: Can also use Fe(2+) and Co(2+).
messages: Catalyzes the transfer of beta-galactose from UDP-galactose to position 4 of alpha-1,6-linked fucose at the reducing end GlcNAc in N-glycan cores (PubMed:19858195). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds (PubMed:20062796).
messages: Expressed in intestine and coelomocytes.
messages: Golgi stack membrane
messages: Inhibited by EDTA, Cu(2+) and Zn(2+).
messages: N-glycosylated.

6239:CELE Y48B6A.7
gene id: 6239:CELE_Y48B6A.7
uniprot id: G5EDN1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C12D5.7
gene id: 6239:CELE_C12D5.7
uniprot id: Q27470
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F33D4.4
gene id: 6239:CELE_F33D4.4
uniprot id: O44186
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sphingolipid delta(4)-desaturase.
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Membrane

6239:CELE F54F7.7
gene id: 6239:CELE_F54F7.7
uniprot id: Q20794
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

6239:CELE C01G8.5
gene id: 6239:CELE_C01G8.5
uniprot id: G5EBK3
uniprot id: G5EES2
names: Subcellular Location Annotation
messages: Membrane
messages: adherens junction
messages: cytoskeleton

6239:CELE F25G6.8
gene id: 6239:CELE_F25G6.8
uniprot id: O16927
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). F37F2.2/srpa-19 together with F25G6.8/srpa-14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of F37F2.2/srpa-19 and F25G6.8/srpa-14 is required for SRP RNA binding (By similarity).
messages: Cytoplasm
messages: Heterodimer with ZK512.4/SRP9; binds RNA as heterodimer (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity).

6239:CELE Y48C3A.7
gene id: 6239:CELE_Y48C3A.7
uniprot id: Q9NAG4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Found in a complex composed of ced-3, ced-4 and mac-1 or of ced-9, ced-4 and mac-1. Within the complex, interacts with ced-4.
messages: Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis.
messages: RNAi-mediated knockdown causes an arrest at the L2-L3 larval stages with few adults reaching adulthood. Abnormal presence of vacuoles in the intestine with some intestinal sections almost completely degraded. RNAi-mediated knockdown in a ced-3 (n718) or ced-4 (n1416) mutant background causes a similar arrest at the L2-L3 larval stages.

6239:CELE B0547.1
gene id: 6239:CELE_B0547.1
uniprot id: P91001
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-1 (PubMed:12781129). Interacts with glh-1 and glh-3 (PubMed:12435362). Interacts with lag-1 (PubMed:10615043). Interacts with kgb-1 (PubMed:17699606).
messages: Cytoplasm
messages: Nucleus
messages: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonizing kgb-1 (PubMed:17699606).
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

6239:CELE ZK858.3
gene id: 6239:CELE_ZK858.3
uniprot id: Q94417
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T01D3.2
gene id: 6239:CELE_T01D3.2
uniprot id: P90953
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Expressed in a small subset of neurons, probably AVJL and AVJR (PubMed:22768843). Expressed in the AVH neurons (PubMed:34604715).
messages: Nucleus
messages: Transcription factor (By similarity). Involved in specifying AVH neuron identity, acting in concert with unc-42 (PubMed:34165428). Involved in serotonin-mediated feeding behavior, probably acting by modulating expression of genes involved in glutamate signaling (PubMed:22768843).
messages: Was reported to probably be expressed in the AVJL and AVJR neurons (PubMed:22768843). However, this has been claimed to be an anatomical error and that expression is restricted to the AVH neurons (PubMed:34604715).

6239:CELE R05H5.2
gene id: 6239:CELE_R05H5.2
uniprot id: Q21762
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

6239:CELE B0454.6
gene id: 6239:CELE_B0454.6
uniprot id: O17167
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F14F4.1
gene id: 6239:CELE_F14F4.1
uniprot id: O62169
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Detected in the ADL sensory neurons, the RMED and RMEV motor neurons, and the PQR tail neuron (PubMed:23112336). In males, detected in SPC tail neurons involved in spicule penetration and sperm transfer, and male-specific oblique muscles involved in vulval contact (PubMed:23112335).
messages: Not directly activated by nematocin (PubMed:23112336, PubMed:23112335). May modulate activity of the nematocin receptor ntr-1, leading to reduced intracellular cAMP production (PubMed:23112335). Plays a role in male mating behavior (PubMed:23112335).
messages: Viable and fertile. Males have reduced reproductive success, due to a range of aberrant mating behaviors. Double knockouts with ntr-1 partially rescue the reproductive phenotypes.

6239:CELE K12G11.4
gene id: 6239:CELE_K12G11.4
uniprot id: O45687
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Homotetramer.

6239:CELE K02D10.1
gene id: 6239:CELE_K02D10.1
uniprot id: P34492
names: Similarity
messages: Belongs to the NipSnap family.

6239:CELE F01E11.4
gene id: 6239:CELE_F01E11.4
uniprot id: Q19083
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y22F5A.5
gene id: 6239:CELE_Y22F5A.5
uniprot id: O62416
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: Expressed in intestine.
messages: Induced in response to Gram-positive bacterium P.aeruginosa infection and to mitochondrial stress in the intestine (PubMed:25274306). Induced in response to Gram-positive bacterium B.thuringiensis (B-18247) infection (PubMed:21931778).
messages: Involved in resistance to Gram-positive bacteria P.aeruginosa or B.thuringiensis infection.
messages: Lacks conserved active site residues, suggesting it has no catalytic activity.
messages: Reduced survival following bacterium B.thuringiensis (B-18247) infection (PubMed:21931778). RNAi-mediated knockdown causes a reduction in survival following bacterium P.aeruginosa infection (PubMed:25274306).

6239:CELE C48B4.1
gene id: 6239:CELE_C48B4.1
uniprot id: P34355
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ATP (By similarity). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (By similarity). ATP binding likely occurs during acox-1.5 folding and/or dimer formation (By similarity).
messages: Belongs to the acyl-CoA oxidase family.
messages: Homodimer.
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains.
messages: Peroxisome

6239:CELE F07B7.4
gene id: 6239:CELE_F07B7.4
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y54G2A.35
gene id: 6239:CELE_Y54G2A.35
uniprot id: Q8MXS7
uniprot id: U4PLH7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C35A5.2
gene id: 6239:CELE_C35A5.2
uniprot id: Q18470
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F30F8.3
gene id: 6239:CELE_F30F8.3
uniprot id: Q93654
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Hermaphrodite and male germlines.
messages: Interacts with syp-3.
messages: Normal brood size, with a slight increase in embryonic and larval lethality (PubMed:36809245). Higher number of male progeny (PubMed:36809245). Increase in germ cell apoptosis (PubMed:36809245).
messages: Nucleus
messages: Phosphorylation at a C-terminal Ser/Thr cluster is required for limiting autosome, but not X chromosome, movement in early prophase I.
messages: Plays a role in early meiotic events; during prophase I contributes to normal meiotic progression, timely homologous chromosome pairing, synaptonemal complex assembly and meiotic DNA double-strand breaks repair (PubMed:36809245). Effects on homologous chromosome pairing and synapsis are alpha-importin-independent (PubMed:36809245). Limits early prophase I chromosome movement in a dhc-1/dynein-dependent manner (PubMed:36809245).
messages: Shares partial functional conservation with human CYTIP in meiotic DNA double-strand break (DSB) repair.
messages: perinuclear region

6239:CELE M04C9.5
gene id: 6239:CELE_M04C9.5
uniprot id: B3WFY8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. RCK subfamily.
messages: Expressed in head neurons including amphid and labial sensory neurons and 3 pairs of neurons in the tail including phasmid sensory neurons. In male, expressed in the tail including the sensory rays and the spicule.
messages: Perikaryon
messages: Sensory neuron cilia are longer, not correctly aligned in the amphid channel, more dispersed, misdirected and sometimes turned back towards the transition zone. Abnormal localization of kap-1 along the full cilia length. Abnormal accumulation in the middle of cilia and in the distal segment and reduced speed along the cilium axoneme of components of the IFT machinery kap-1, osm-3, xbx-1, che-11 and osm-5. In a kap-1 mutant background, 30 percent of mutants have branched cilia. In a kap-1 and osm-3 double mutant background, loss of cilia formation.
messages: Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and kap-1) before reaching the distal segment and the docking of kinesin motor osm-3 onto IFT cargos.
messages: axon
messages: cilium
messages: dendrite

6239:CELE C34E10.1
gene id: 6239:CELE_C34E10.1
uniprot id: P46576
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the SAM50/omp85 family.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: May play a role in the maintenance of the structure of mitochondrial cristae.
messages: Mitochondrion outer membrane

6239:CELE C23G10.2
gene id: 6239:CELE_C23G10.2
uniprot id: Q10121
names: Similarity
messages: Belongs to the RutC family.

6239:CELE T21C9.2
gene id: 6239:CELE_T21C9.2
uniprot id: D7SFN0
uniprot id: Q22639
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi.
messages: Belongs to the VPS54 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-52 and vps-53 (PubMed:21613545).
messages: Mutants are viable but display reduced brood size and enlarged lysosomes.
messages: trans-Golgi network

6239:CELE C09G5.2
gene id: 6239:CELE_C09G5.2
uniprot id: Q09454
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the dph-1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph-1 subunit (By similarity).

6239:CELE K06C4.6
gene id: 6239:CELE_K06C4.6
uniprot id: Q9GQ00
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Expressed in a subset of muscles, and head and tail neurons, including RME and GABAergic ventral nerve cord neurons (PubMed:23023001). Expressed in AIY, RME, RID, RIF, ASI, DD1-6, and PVN neurons (PubMed:23972393).
messages: Expressed in all body-wall muscles in L3 stage larvae, and at a lower level in L4 stage larvae and adults.
messages: Functions as a 5-hydroxytryptamine (serotonin) receptor (PubMed:11100728, PubMed:12783521, PubMed:23023001). This receptor is a ligand-gated anion-specific ion channel, selective for chloride ions (PubMed:11100728, PubMed:15878844). Relays a long-range endocrine signal from the body cavity neurons to modulate distal adipose triglyceride lipase atgl-1 function, via the nuclear receptor nhr-76 (PubMed:24120942). Together with the G-protein coupled serotonin receptor ser-1 involved in male mating behavior (PubMed:16291940). May mediate an inhibitory effect of serotonin on egg laying (PubMed:16291940). Involved in regulating locomotory behavior, perhaps by modulating interneuronal signaling, acting in concert with G-protein coupled serotonin receptor ser-4 (PubMed:19193891, PubMed:23023001). In the presence of food, plays a role in initiating and extending dwelling behavior, perhaps acting in AIY, RIF and ASI neurons, in opposition to neuropeptide PDF-mediated signaling (PubMed:23972393). Plays a role in aversive learning upon exposure to pathogens such as Gram-negative bacterium P.aeruginosa strain PA14; perhaps acting in interneurons in response to serotonin released by the serotonergic ADF neurons (PubMed:16281027).
messages: Membrane

6239:CELE F26F4.10
gene id: 6239:CELE_F26F4.10
uniprot id: Q19825
uniprot id: Q65ZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
messages: cytosol

6239:CELE Y53C10A.15
gene id: 6239:CELE_Y53C10A.15
uniprot id: Q18LB3
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T01G9.2
gene id: 6239:CELE_T01G9.2
uniprot id: P34692
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAF1 family.
messages: Cytoplasm
messages: May play a regulatory role in autophagic activity.
messages: Preautophagosomal structure
messages: Was originally thought to be lin-10.

6239:CELE F10D2.8
gene id: 6239:CELE_F10D2.8
uniprot id: A0A131MBU2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y46H3A.3
gene id: 6239:CELE_Y46H3A.3
uniprot id: V6CLQ2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F08G12.10
gene id: 6239:CELE_F08G12.10
uniprot id: Q9U3K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C02F4.1
gene id: 6239:CELE_C02F4.1
uniprot id: G5EEN3
names: Similarity
messages: Belongs to the DOCK family.

6239:CELE B0222.3
gene id: 6239:CELE_B0222.3
uniprot id: Q17455
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

6239:CELE Y38H8A.4
gene id: 6239:CELE_Y38H8A.4
uniprot id: O62424
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F56F11.3
gene id: 6239:CELE_F56F11.3
uniprot id: Q9TZ64
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in all developmental stages, increasing gradually from embryo to larval L4 stage, decreasing and stabilizing in adult stage (PubMed:18680432). Expressed in intestine in all larval and adult stages, and in a few neuronal and hypodermal cells (PubMed:18680432).
messages: Expressed in intestine, hypodermis and a few neurons.
messages: Induced by treatment with high levels of paraquat, a chemical causing production of reactive oxygen species (ROS), but not by other exogenous stressors, such as heat shock or osmotic stress.
messages: Interacts with E3 ubiquitin-protein ligase wwp-1 (via WW domains).
messages: Nucleus
messages: RNAi-mediated knockown leads to increased cell death, perhaps by apoptosis, in the germline and uterus of hermaphrodites (PubMed:18680432). Lipid contents in the intestine increase (PubMed:18680432). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825). Abolishes lifespan extension on either isp-1;ctb-1 double mutant, or isp-1, gas-1 or mev-1 single mutant backgrounds; knockdown is most effective when applied in early adulthood, rather than during early development (PubMed:31346165). Further decreases the lower movement rates of isp-1;ctb-1 double mutants (PubMed:31346165).
messages: Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165). Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165). Involved in the response to oxidative stress (PubMed:31346165). Plays a role in cell death (PubMed:18680432).
messages: Ubiquitinated; probably preferentially monoubiquitinated by wwp-1.

6239:CELE Y25C1A.12
gene id: 6239:CELE_Y25C1A.12
uniprot id: Q9TYL5
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y48A5A.2
gene id: 6239:CELE_Y48A5A.2
uniprot id: Q86FN3
names: Similarity
messages: Belongs to the peptidase C48 family.

6239:CELE T04D3.3
gene id: 6239:CELE_T04D3.3
uniprot id: B5BM35
uniprot id: O18696
names: Cofactor
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Expressed in AFD thermosensory neurons.
messages: Interacts with cmd-1 in the presence of Ca(2+).
messages: Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.

6239:CELE F09F3.5
gene id: 6239:CELE_F09F3.5
uniprot id: P90820
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxidase family.
messages: Expressed in the hypodermis and gland cells of the pharynx (PubMed:30695063). Specifically, there is low and transient expression from the distal bulb of the pharynx to the anterior of the buccal cavity (PubMed:30695063). Whole body expression levels increase upon entry into the dauer phase (PubMed:30695063).
messages: Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx (PubMed:30695063). It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans (PubMed:24621828, PubMed:30695063).
messages: RNAi-mediated knockdown results in reduced survival in response to infection by E.faecalis.
messages: Secreted

6239:CELE F48E8.5
gene id: 6239:CELE_F48E8.5
uniprot id: Q09543
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1 (PubMed:23336080, PubMed:17218259). During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation (PubMed:10521400). Plays a positive role in axon guidance probably by inhibiting phosphatase let-92 (PubMed:20392746).
messages: Belongs to the phosphatase 2A regulatory subunit A family.
messages: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
messages: Part of a complex consisting of a common heterodimeric core enzyme, composed of catalytic subunit let-92 and constant regulatory subunit paa-1, that associates with a variety of regulatory subunits which confer distinct properties to the holoenzyme (PubMed:17218259, PubMed:21497766). Interacts with rsa-1 (PubMed:17218259).
messages: RNAi-mediated knockdown causes severe embryonic lethality (PubMed:10521400, PubMed:23336080). Causes a failure to duplicate centrioles resulting in the formation of monopolar spindles at the 2-cell embryonic stage (PubMed:21497766, PubMed:23336080). sas-5 protein levels are reduced in embryos (PubMed:21497766). The few surviving animals lack a vulva resulting from defects in vulva cell induction, vulva precursor cell (VPC) generation and in vulval execution linage (PubMed:10521400). Partially suppresses multivulva formation in a let-60 n1046 mutant background (PubMed:10521400).
messages: centrosome
messages: spindle

6239:CELE C04G6.1
gene id: 6239:CELE_C04G6.1
uniprot id: H2KYF8
uniprot id: Q6ABN8
uniprot id: Q8IG56
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

6239:CELE Y67H2A.6
gene id: 6239:CELE_Y67H2A.6
uniprot id: Q95PZ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center. Its function as protease is therefore unsure.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2 and csn-4. Interacts with rbx-1.
messages: Cytoplasm
messages: Nucleus

6239:CELE T13H10.2
gene id: 6239:CELE_T13H10.2
uniprot id: Q7YWT8
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE ZK1005.1
gene id: 6239:CELE_ZK1005.1
uniprot id: Q9TXQ1
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By irradiation (PubMed:14706351, PubMed:19104912). This induction is dependent on hus-1 (PubMed:14706351).
messages: Chromosome
messages: Detected at all stages (PubMed:14706351, PubMed:19104912). Expressed at low level in embryos compared to larvae (PubMed:14706351). Peaks in young adults (PubMed:14706351).
messages: Expressed throughout the head and tail, in germ cells and somatic cells.
messages: Nucleus
messages: Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.

6239:CELE C06G3.9
gene id: 6239:CELE_C06G3.9
uniprot id: Q17750
names: Function
names: Similarity
messages: Belongs to the UFL1 family.
messages: E3 UFM1-protein ligase that mediates ufmylation of target proteins.

6239:CELE F22F7.3
gene id: 6239:CELE_F22F7.3
uniprot id: Q9GZF2
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE D2092.5
gene id: 6239:CELE_D2092.5
uniprot id: P91193
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity. In AWA and AWC neurons, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl and isoamyl alcohol (PubMed:28924007). May play a role in regulating daf-7 expression in ASI neurons in response to bacterial small RNAs (PubMed:32908307). In ASI neurons, promotes dauer formation in response to pheromones such as the ascarosides ascr#2 and ascr#3 (PubMed:26976437).
messages: RNAi-mediated knockdown results in defective avoidance behavior in response to P.aeruginosa.
messages: Rough endoplasmic reticulum membrane
messages: Strong expression in many neurons, very weak expression is also detected in others tissues.

6239:CELE Y63D3A.8
gene id: 6239:CELE_Y63D3A.8
uniprot id: G5EF48
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed throughout development.
messages: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).
messages: Ubiquitously expressed.

6239:CELE C53B7.1
gene id: 6239:CELE_C53B7.1
uniprot id: Q18806
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling.
messages: Expressed in the cholinergic motor neurons AS, VA and DA in the ventral nerve cord and in the mechanosensory ALM neurons in the midbody.
messages: RNAi-mediated knockdown results in hypersensitivity to the acetylcholinesterase inhibitor aldicarb, indicating increased cholinergic transmission in mutant animals.
messages: Synapse
messages: axon

6239:CELE F56D12.6
gene id: 6239:CELE_F56D12.6
uniprot id: H2KYR2
uniprot id: Q9TXS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

6239:CELE C27B7.7
gene id: 6239:CELE_C27B7.7
uniprot id: Q18245
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F26E4.6
gene id: 6239:CELE_F26E4.6
uniprot id: O18687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE ZK686.2
gene id: 6239:CELE_ZK686.2
uniprot id: P34668
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: Probable ATP-binding RNA helicase.

6239:CELE F57C7.3
gene id: 6239:CELE_F57C7.3
uniprot id: P50605
uniprot id: Q8I4H9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell junction
messages: Cell surface
messages: Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2 (PubMed:25344071). Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts (PubMed:26022293). Promotes the axon guidance of D-type motor neurons (PubMed:24066155).
messages: Cell surface proteoglycan.
messages: Cytoplasm
messages: Disrupted mitotic spindle orientation of the ABar blastomere division axis, orientating parallel rather than orthogonally to the division axis of AB derived cells ABpr and ABal (PubMed:25344071). Reduced mig-5 accumulation at the cell contact sites between the ABar and C blastomere cells (PubMed:25344071). Irregular positioning of the AQR and PQR neurons in larva at the L4 stage (PubMed:26022293).
messages: Expressed from the one-cell stage of embryogenesis onwards.
messages: Membrane
messages: The cytoplasmic domain is required for correct mitotic spindle orientation and internalization of sdn-1.

6239:CELE C54F6.11
gene id: 6239:CELE_C54F6.11
uniprot id: Q5CCI8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R11D1.11
gene id: 6239:CELE_R11D1.11
uniprot id: Q21929
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of L-xylulose, D-xylulose, L-(+) erythrulose, D-erythrose, D-threose, L-ribulose, 1,4-dibromo-2,3-butanedione and 2,3-heptanedione (PubMed:21477590). Also active against isatin, 9,10-phenanthrenequinone, menadione, 2,3-hexaenadione and 3,4-hexahenadione (PubMed:21300042). No activity observed when tested using NADH rather than NADPH (PubMed:21300042).
messages: Cell membrane
messages: Detected at the two-fold embryo stage. Expressed in the intestine during L1 to L3, followed by expression in uterine seam, gonadal sheath cells and spermathecal-uterus valve at L4.
messages: Expressed in intestine, gonad and spermatids (at protein level). Expressed in intestine, uterine seam, gonadal sheath cells, spermathecal-uterus valve and spermatids.
messages: Homotetramer.
messages: Reduced life span and impaired egg-laying function resulting in the retention of eggs. Exogenous addition of serotonin, which triggers vulval muscle contraction, or imipranine, a serotonin uptake inhibitor, rescues the ability to lay eggs, showing that the morphology of the vulva muscles and HSN neurons is normal.
messages: Strongly inhibited by 10% dimethyl sulfoxide.

6239:CELE F20B6.8
gene id: 6239:CELE_F20B6.8
uniprot id: Q8MQ70
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
messages: Broadly expressed during embryogenesis (PubMed:12618396, PubMed:29036198). Expression becomes more restricted during larval development (PubMed:29036198). L3 larvae display robust expression in many head and motor neurons, and lower levels of expression in the intestine and the seam cells of the hypodermis (PubMed:29036198). By late L4 stage, expression is largely restricted to neurons and is maintained in nerve cells of the head and nerve cord during adulthood (PubMed:29036198). Expressed in adult pharyngeal cells, hypodermal cells, gonadal sheath cells and distal tip cells but not in germline cells (PubMed:23904186).
messages: Enhanced sensitivity to heat and oxidative stress with reduced survival under both conditions (PubMed:26791749, PubMed:29036198). Following exposure to gamma irradiation, no effect on DNA damage response in the germline but significantly reduced embryonic survival (PubMed:26791749). Significantly reduced lifespan with a more rapid decline in body movement and pharyngeal pumping, indicative of accelerated aging (PubMed:26791749, PubMed:29036198). Premature accumulation of polyglutamine aggregates and increased polyglutamine-associated paralysis at day 8 of adulthood (PubMed:29036198). RNAi-mediated knockdown results in small and underdeveloped germlines with a reduction in the number of cells in G2/M stages (PubMed:23904186). RNAi-mediated knockdown from the L1 larval stage onwards results in shortened lifespan while RNAi-mediated knockdown initiated at the L4 larval stage decreases lifespan to a smaller but significant extent (PubMed:29036198, PubMed:36173858). RNAi-mediated knockdown in the intestine, hypodermis or neurons reduces lifespan while RNAi-mediated knockdown in muscle cells does not (PubMed:29036198).
messages: Induced by heat stress (PubMed:23904186, PubMed:26791749, PubMed:29036198). Transcription from the hpk-1 promoter is not altered by heat shock treatment, suggesting that heat shock affects hpk-1 levels through a post-transcriptional mechanism (PubMed:26791749). Induction is greatest in hypodermal seam cells and neurons with much lower levels of induction in intestinal cells (PubMed:29036198).
messages: Nucleus
messages: Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood (PubMed:23904186). Plays a role in the development/differentiation of gonadal distal tip cells (PubMed:23904186). Required for normal lifespan in a pha-4 and mxl-2-dependent manner (PubMed:26791749, PubMed:29036198, PubMed:36173858). Also contributes to survival following heat or oxidative stress (PubMed:26791749). Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock (PubMed:29036198). Also required for hormetic extension of longevity in response to heat stress (PubMed:29036198). Provides protection against polyglutamine aggregate formation and associated locomotory toxicity (PubMed:29036198). Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression (PubMed:29036198).

6239:CELE T04A8.2
gene id: 6239:CELE_T04A8.2
uniprot id: P46569
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE K07B1.1
gene id: 6239:CELE_K07B1.1
uniprot id: O01887
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Expressed in male L4 larvae and adults.
messages: In the male gonad, probably maintained inactive by swm-1.
messages: Secreted
messages: Serine protease which, in males, acts as a promoting signal during mating to activate sperm.
messages: Specifically expressed in the male gonad including the seminal vesicle, the valve region and the vas deferens.
messages: secretory vesicle lumen

6239:CELE F55B12.1
gene id: 6239:CELE_F55B12.1
uniprot id: Q9NLC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-2 homeobox family.
messages: Expressed in the 8 vulval muscles, 8-10 ventral neurons in the head and in the most posterior pharyngeal muscle cell, m8 (PubMed:9425137). Expressed in SIA, SIB and SMB sublateral motor neurons, and in muscles of the pharynx and vulva (PubMed:28244369).
messages: First expressed in the m8 pharyngeal muscle cell and in ventral head neurons in embryos 400 minutes after the first cell cleavage.
messages: Normal growth, coordination, egg-laying, mating, chemotaxis, pharyngeal pumping and VC neuron synapses as in wild-type animals (PubMed:9425137). Abnormal sleep behavior with mutant larvae displaying a reduced, if not absent, type of turning behavior called 'flipping' (PubMed:28244369). Irregular formation and extension of sublateral motor neuron processes (PubMed:28244369).
messages: Nucleus
messages: Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.

6239:CELE T28C6.6
gene id: 6239:CELE_T28C6.6
uniprot id: G5EDG6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZK546.17
gene id: 6239:CELE_ZK546.17
uniprot id: Q7Z144
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMACHC family.
messages: Can utilize both FAD and FMN.
messages: Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives.
messages: Cytoplasm

6239:CELE D1081.8
gene id: 6239:CELE_D1081.8
uniprot id: G5EFC4
names: Similarity
messages: Belongs to the CEF1 family.

6239:CELE Y66A7A.8
gene id: 6239:CELE_Y66A7A.8
uniprot id: O45291
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F56H11.4
gene id: 6239:CELE_F56H11.4
uniprot id: G5EEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme that catalyzes the elongation of monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Membrane

6239:CELE JC8.8
gene id: 6239:CELE_JC8.8
uniprot id: O62289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE B0563.2
gene id: 6239:CELE_B0563.2
uniprot id: Q17526
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE T28C6.4
gene id: 6239:CELE_T28C6.4
uniprot id: G5EDG6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F47C10.7
gene id: 6239:CELE_F47C10.7
uniprot id: A0A168H5N7
uniprot id: O01562
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y54E2A.11
gene id: 6239:CELE_Y54E2A.11
uniprot id: Q9XWI6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: Extended lifespan in adults.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

6239:CELE W08F4.3
gene id: 6239:CELE_W08F4.3
uniprot id: O02109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Vesicle

6239:CELE F35H10.7
gene id: 6239:CELE_F35H10.7
uniprot id: Q20069
uniprot id: X5LXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome
messages: Lysosome membrane
messages: Probably part of the GATOR complex.

6239:CELE R10H1.4
gene id: 6239:CELE_R10H1.4
uniprot id: Q8MPZ7
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F38A5.22
gene id: 6239:CELE_F38A5.22
uniprot id: V6CLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T22D1.9
gene id: 6239:CELE_T22D1.9
uniprot id: Q9GZH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

6239:CELE F02E8.5
gene id: 6239:CELE_F02E8.5
uniprot id: Q19124
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat tipD family.
messages: Cytoplasm
messages: Expressed in neurons, pharyngeal muscles, body wall muscle cells and intestinal cells.
messages: Expressed throughout development.
messages: Homodimer (via N-terminus) (PubMed:24185444). Most likely a component of a complex at least containing atg-5, lgg-3, atg-16.1 and/or atg-16.2 (Probable). Interacts (via N-terminus) with atg-16.2 (via N-terminus) (PubMed:24185444). Interacts (via N-terminus) with atg-5 (PubMed:24185444). Interacts (via WD domain) with lgg-2; the interaction is direct (PubMed:26687600).
messages: Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation (PubMed:24185444, PubMed:26687600). Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.2 to regulate autophagic processes (PubMed:24185444).

6239:CELE B0302.1
gene id: 6239:CELE_B0302.1
uniprot id: Q10925
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cytoplasm
messages: Defective in transport of silencing RNAs but not defective in execution of RNAi. Marginal enhancement of cell-autonomous RNAi. Mildly defective in silencing the intestine-expressed gene, act-5.
messages: Expressed throughout all developmental stages.
messages: The kinase domain is required for import of dsRNA into cells.
messages: Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues.
messages: Ubiquitously present in all tissues tested. Expressed in the somatic cells of gut, pharynx, body wall muscle, neurons, skin and excretory canal cells.

6239:CELE T13C2.6
gene id: 6239:CELE_T13C2.6
uniprot id: H2KZX4
uniprot id: Q7JP80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y43B11AR.5
gene id: 6239:CELE_Y43B11AR.5
uniprot id: Q86B42
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F36A4.7
gene id: 6239:CELE_F36A4.7
uniprot id: P16356
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Chromosome
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits (By similarity). Interacts with sig-7 (PubMed:27541139).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). Involved in the transcription of several genes including those involved in embryogenesis (PubMed:14726532, PubMed:27541139).
messages: Expressed in embryo. During embryonic development, the form phosphorylated at 'Ser-2' of the C-terminal heptapeptide repeats is present only in transcriptionally active somatic cells.
messages: Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1260 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery. Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic arrest at the 100-cell stage and prevents the embryonic transcription of several genes (PubMed:14726532). Surviving embryos exhibit gastrulation defects with decreased expression of genes involved in gastrulation (PubMed:27541139).
messages: The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.
messages: The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II (By similarity). Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat and starts at the 3- to 4-cell embryonic stage (PubMed:14726532, PubMed:17291483). This phosphorylation also occurs in the early stages of oocyte development and is not detected in oocytes arrested at the meiotic diakinesis stage (PubMed:17291483). In the somatic lineage, phosphorylation at 'Ser-2' is mediated by cdk-12 downstream of cdk-9 whereas in the germline lineage cdk-12 phosphorylates 'Ser-2' independently of cdk-9 (PubMed:23903194). Phosphorylation is likely mediated by cdk-7 (PubMed:11960010). May be dephosphorylated by fcp-1 in diakinetic oocytes and in 1-cell and 2-cell embryos (PubMed:17291483). Dephosphorylated at 'Ser-5' of the heptapeptide repeats by ssup-72 (PubMed:26588990). The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed (By similarity).

6239:CELE F36F12.3
gene id: 6239:CELE_F36F12.3
uniprot id: A0A0K3ASG7
uniprot id: A0A0K3AXS7
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y41D4B.13
gene id: 6239:CELE_Y41D4B.13
uniprot id: Q9NHC3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRK family.
messages: Dead cells/corpses fail to be engulfed. Defective in the migration of distal tip cells and gonad development. Actin halos are absent.
messages: Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region) (PubMed:10707082, PubMed:11703940, PubMed:21616056). Forms a ternary complex with ced-5 and ced-12 (PubMed:11703940). Interacts (via SH2 domain) with src-1 (when activated and phosphorylated at 'Tyr-416') (PubMed:20226672).
messages: Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis (PubMed:10707082, PubMed:6857247, PubMed:1936965, PubMed:11449278, PubMed:15744306, PubMed:19402756, PubMed:20226672). Has a role in the migration of the 2 gonadal distal tip cells (DTCs) (PubMed:10707082). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382).

6239:CELE K02B9.1
gene id: 6239:CELE_K02B9.1
uniprot id: Q21126
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic granule
messages: Expressed in the P lineage during embryogenesis (PubMed:18202375). First expressed at the 4- to 8-cell stage, and expression remains throughout the remaining P cell divisions in P2, P3 and P4 cells, and subsequently in primordial germ cells Z2 and Z3 (PubMed:18202375). Expression begins to diminish at the 100-cell stage (PubMed:18202375).
messages: Interacts with pptr-1, pptr-2 and pgl-1.
messages: Not expressed in the adult germline or in any somatic tissues.
messages: P granule component, which acts redundantly with P granule component meg-2 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages (PubMed:18202375, PubMed:21305687, PubMed:25535836). In its phosphorylated form, and together with meg-2, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). In its dephosphorylated form, and together with meg-2, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). May function with the nanos family members nos-2 and nos-3 to promote germ cell proliferation during larval development (PubMed:21305687). Required for fertility (PubMed:18202375, PubMed:21305687).
messages: Phosphorylated by mbk-2, which promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). Dephosphorylated by a phosphatase complex containing the PP2A regulatory subunit pptr-1, which promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836).
messages: RNAi-mediated knockdown results in sterility, and in P granule segregation defects (PubMed:18202375). Simultaneous RNAi-mediated knockdown of meg-1 and meg-2 results in defects in P granule disassembly in the anterior cytoplasm of the P1 blastomere causing some P granules to be mis-segregated to somatic blastomeres (PubMed:25535836).

6239:CELE Y49C4A.9
gene id: 6239:CELE_Y49C4A.9
uniprot id: Q965T7
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C34G6.4
gene id: 6239:CELE_C34G6.4
uniprot id: A0A0K3AQN5
uniprot id: A0A0K3AU66
uniprot id: A0A0K3AWK1
uniprot id: G5EDF9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C54C6.1
gene id: 6239:CELE_C54C6.1
uniprot id: P49622
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

6239:CELE R06C7.3
gene id: 6239:CELE_R06C7.3
uniprot id: Q21773
names: Cofactor
names: Developmental Stage
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Expressed in dorsal regions of embryos at late gastrula stage, transiently expressed in the developmental process of 3-fold embryo to L1-L2 larval stage.
messages: Homotetramer.
messages: In L1-L2 larvae, expressed in body hypodermal cells, hemidesmosomes and in a neuronal cell between the pharynx and ring neuropil. In adults, expression is seen in body hypodermal cells and pharynx.
messages: Nucleus

6239:CELE M02B1.3
gene id: 6239:CELE_M02B1.3
uniprot id: A0A061AD30
uniprot id: Q93892
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y43F8C.10
gene id: 6239:CELE_Y43F8C.10
uniprot id: Q9XWN9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: Expressed in cells of the male tail tip from the L3 larval stage. Expression peaks during male tail tip retraction and decreases rapidly upon completion (PubMed:18550714). Not expressed in cells of the hermaphrodite tail tip at any developmental stage (PubMed:18550714).
messages: In males, expressed in the tail tip (PubMed:18550714, PubMed:21408209, PubMed:22069471, PubMed:30910805). Specifically, expressed in 15 male-specific muscles of the tail tip called the diagonal muscles, and also in core body muscles of both males and hermaphrodites (PubMed:22069471). In males, expressed in ray A-neurons (PubMed:18550714, PubMed:22069471). In males, expressed in PHC sensory neurons (PubMed:28065609). In males, it is also expressed in the hindgut, B lineage and somatic gonad (PubMed:18550714). In hermaphrodites, expressed in the anchor cell only (PubMed:18550714).
messages: Negatively regulated by lin-41 which causes degradation of the mRNA encoding this protein.
messages: Nucleus
messages: Perikaryon
messages: RNAi-mediated knockdown results in male tail morphology defects.
messages: Transcriptional activator which promotes male-specific development (PubMed:18550714, PubMed:28065609). Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis (PubMed:18550714, PubMed:30910805). This is most likely through the regulation of downstream effectors such as eff-1 (PubMed:18550714). May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells (PubMed:21408209). In males, plays a role in the development of ray A-neurons by negatively regulating the activity of the transcription factor ast-1 (PubMed:22069471). Plays a role in the male-specific differentiation of PHC sensory neurons into densely connected hub sensory neurons (PubMed:28065609). Plays a role in male mating behavior (PubMed:22069471).

6239:CELE R53.6
gene id: 6239:CELE_R53.6
uniprot id: Q22019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

6239:CELE ZK697.2
gene id: 6239:CELE_ZK697.2
uniprot id: O44577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE K08D10.7
gene id: 6239:CELE_K08D10.7
uniprot id: Q21319
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE D2030.5
gene id: 6239:CELE_D2030.5
uniprot id: G5EEG4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

6239:CELE Y50D7A.10
gene id: 6239:CELE_Y50D7A.10
uniprot id: Q8IAA5
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

6239:CELE R07B1.3
gene id: 6239:CELE_R07B1.3
uniprot id: Q09606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Membrane

6239:CELE R166.5
gene id: 6239:CELE_R166.5
uniprot id: Q8I113
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed in pharynx, intestine, vulva and body wall muscles.
messages: Nucleus
messages: RNAi-mediated knockdown causes a reduction in lifespan but not in a glp-4 bn2 mutant background. In an ife-2 ok306 mutant background, partially reduces the lifespan increase (PubMed:17277769). In a rfl-1 or198 mutant background, partially rescues embryonic viability by restoring normal cytokinesis (PubMed:19528325).
messages: Serine/threonine-protein kinase which is required in the germline to regulate positively lifespan (PubMed:17277769). May play a role in body wall muscle contraction (PubMed:25851606). May be involved in embryonic cytokinesis (PubMed:19528325).

6239:CELE T15B7.3
gene id: 6239:CELE_T15B7.3
uniprot id: O17038
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F40F4.5
gene id: 6239:CELE_F40F4.5
uniprot id: Q20221
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE Y62F5A.1
gene id: 6239:CELE_Y62F5A.1
uniprot id: Q9U1W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F43G6.1
gene id: 6239:CELE_F43G6.1
uniprot id: Q9U3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

6239:CELE F49H12.6
gene id: 6239:CELE_F49H12.6
uniprot id: Q9N5S8
uniprot id: Q9N5S9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE ZK1251.8
gene id: 6239:CELE_ZK1251.8
uniprot id: A0A061AD18
uniprot id: Q23435
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Expressed in ray A-type neurons and cell bodies. Also seen in head, pharyngeal and phasmid neurons, and in coelomocytes.
messages: Membrane
messages: Potassium channel protein that may be component of regulatory network that controls ray development and function.

6239:CELE F28F8.5
gene id: 6239:CELE_F28F8.5
uniprot id: H9G301
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Described as a member of the Mediator complex and a probable MED28 ortholog but shows very low similarity to known MED28 proteins and lacks the Pfam Med28 signature found in known MED28 proteins.
messages: Expressed from embryos to adults. Expressed in embryos from the two-fold stage, and is ubiquitously expressed during embryonic and larval stages of development.
messages: Interacts with mdt-6 and mdt-30.
messages: Nucleus
messages: Plays a role in normal growth and development.
messages: Ubiquitously expressed in tissues including epidermal, intestinal, pharyngeal and uterine, and is also expressed in vulval muscle cells and gut granules.
messages: Viable, but sterile with defective development that is prominent during the late larval stages of development. The developmental defects include a squat body stature referred to as a dumpy phenotype, irregular gut, defective gonadal growth, with incomplete gonad development in some animals, a protruding vulva phenotype, defective uterus and spermatheca formation, and excretory canal defects. RNAi-mediated knockdown results in 44% of animals arresting at either the embryonic or larval stage of development, and in a range of phenotypes including defective molting, protruding vulvae that burst, male tail ray defects and uncoordinated movement.

6239:CELE T05F1.6
gene id: 6239:CELE_T05F1.6
uniprot id: Q7JKP6
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in germ cells.
messages: Induced by DNA damage cues including gamma-irradiation, and UV and hydroxyurea treatment.
messages: May have a role in DNA double-strand break repair following gamma-irradiation.
messages: Nucleus
messages: Reduced number of apoptotic cells following gamma-irradiation. In a rad-54 knockdown but not in brc-1 mutant background, restores levels of embryonic survival and chromosomal aberrations in oocytes following gamma-irradiation to almost wildtype. Mutants show slightly reduced levels of egl-1 mRNA expression.

6239:CELE C35C5.5
gene id: 6239:CELE_C35C5.5
uniprot id: Q93329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE Y51B9A.6
gene id: 6239:CELE_Y51B9A.6
uniprot id: B6GUQ1
uniprot id: Q9XXC1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y39A1A.23
gene id: 6239:CELE_Y39A1A.23
uniprot id: Q95Q27
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rad9 family.
messages: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
messages: Putative component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of hpr-9, mrt-2 and hus-1 (Probable).
messages: RNAi-mediated knockdown disrupts hus-1 localization to the nucleus.

6239:CELE Y106G6D.4
gene id: 6239:CELE_Y106G6D.4
uniprot id: Q9XX60
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE W02B12.6
gene id: 6239:CELE_W02B12.6
uniprot id: Q23122
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Mitochondrion
messages: Monomer.

6239:CELE C32C4.7
gene id: 6239:CELE_C32C4.7
uniprot id: Q52GY8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F22B7.6
gene id: 6239:CELE_F22B7.6
uniprot id: P34409
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
messages: Divalent metal cations. Prefers Mg(2+), but can also use Mn(2+).
messages: Nucleus
messages: The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.

6239:CELE Y43F8A.4
gene id: 6239:CELE_Y43F8A.4
uniprot id: Q9XWL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE EEED8.16
gene id: 6239:CELE_EEED8.16
uniprot id: Q95QN6
names: Function
names: Subcellular Location Annotation
messages: Acts as a Ras responsive E3 ubiquitin ligase (By similarity). Controls the stress response to increased levels of reactive oxygen species (ROS) by modulating the brc-1-dependent expression of cki-1 (PubMed:20207739, PubMed:28600327). Modulates expression of phase II detoxification genes such as gst-4, gst-7, sdz-8 and ugt-13, in a transcription factor skn-1-dependent manner (PubMed:28600327).
messages: Cytoplasm

6239:CELE Y18D10A.1
gene id: 6239:CELE_Y18D10A.1
uniprot id: Q9XW25
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T08B1.2
gene id: 6239:CELE_T08B1.2
uniprot id: K8ERV5
uniprot id: O44556
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

6239:CELE Y95B8A.10
gene id: 6239:CELE_Y95B8A.10
uniprot id: G8JYF6
uniprot id: V6CIW4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

6239:CELE ZK353.7
gene id: 6239:CELE_ZK353.7
uniprot id: P34630
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the CutC family.
messages: Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size.
messages: Reduced copper tolerance, which results in reduced brood size and retarded body length, protruding vulva (pvl) phenotype.

6239:CELE F14F7.1
gene id: 6239:CELE_F14F7.1
uniprot id: O17805
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y53G8B.4
gene id: 6239:CELE_Y53G8B.4
uniprot id: A3KFD2
uniprot id: G4S7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

6239:CELE F58F6.1
gene id: 6239:CELE_F58F6.1
uniprot id: O44174
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y48C3A.14
gene id: 6239:CELE_Y48C3A.14
uniprot id: H1UBJ9
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

6239:CELE Y5H2B.6
gene id: 6239:CELE_Y5H2B.6
uniprot id: Q9N4Q4
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F26A3.2
gene id: 6239:CELE_F26A3.2
uniprot id: Q93594
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp-1 and ncbp-2 that interacts with m7GpppG-capped RNA.
messages: Lethality in 98.7% of embryos.
messages: Nucleus

6239:CELE C28A5.4
gene id: 6239:CELE_C28A5.4
uniprot id: Q18273
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the distal-less homeobox family.
messages: Expressed in dopaminergic neurons throughout the life of the neurons.
messages: Nucleus
messages: Predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons.
messages: Probable transcription factor (PubMed:23788625). Binds to the sequence motif 5'-ATAAT-3' in regulatory elements (PubMed:23788625). Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability (PubMed:11747075). Modulates and maintains dopaminergic neuron differentiation (PubMed:23788625). May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20 (PubMed:23788625).

6239:CELE C33G8.9
gene id: 6239:CELE_C33G8.9
uniprot id: Q18394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE R08C7.3
gene id: 6239:CELE_R08C7.3
uniprot id: Q27511
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expressed in somatic gonadal cells.
messages: May be acetylated.
messages: Monoubiquitination of Lys-124 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: RNAi-mediated knockdown results in sterility.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AV forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).

6239:CELE Y51F10.11
gene id: 6239:CELE_Y51F10.11
uniprot id: Q4W5H0
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

6239:CELE C25A8.4
gene id: 6239:CELE_C25A8.4
uniprot id: Q18143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Putative chitinase.
messages: Secreted

6239:CELE F32B6.1
gene id: 6239:CELE_F32B6.1
uniprot id: O45436
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZC410.10
gene id: 6239:CELE_ZC410.10
uniprot id: G5EFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

6239:CELE R06C7.7
gene id: 6239:CELE_R06C7.7
uniprot id: B2D6M2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Expressed from the one-cell embryo to the adult (at protein level).
messages: Interacts preferentially with histone H3 that is dimethylated or trimethylated at 'Lys-9'.
messages: Multivulva phenotype in combination with loss of function of class A synMuv genes lin-8, lin-38, lin-56 and lin15A and with the class B synMuv gene hpl-2. Reduction of brood size and defects in the development of germ cells. Loss of function results in suppression of mat-3(ku233) mutant vulval phenotype.
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
messages: The MBT repeats specifically recognize and bind histone H3 di- and tri-methylated at 'Lys-9' (H3K9me2/3).

6239:CELE F35F10.1
gene id: 6239:CELE_F35F10.1
uniprot id: Q9GYT3
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F46H6.2
gene id: 6239:CELE_F46H6.2
uniprot id: H2KYI9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

6239:CELE F40F9.9
gene id: 6239:CELE_F40F9.9
uniprot id: G5EEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE F11A6.1
gene id: 6239:CELE_F11A6.1
uniprot id: O17798
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Binds 3 calcium ions per subunit.
messages: Cell membrane
messages: Expressed in embryos, larvae and adults (PubMed:25232734). Broadly expressed in embryos (PubMed:28846083). Expressed broadly in neuronal and epithelial cells throughout the head during the dauer stage (PubMed:23932402).
messages: Expressed in the nervous system including the ventral nerve cord, the nerve ring and the retrovesicular ganglion, and in epithelial cells (PubMed:23932402, PubMed:24671950, PubMed:25232734). Expressed in IL2 neurons (PubMed:23932402). Expressed in PVD mechanosensory neurons (PubMed:25232734). Expressed in pharynx with strong expression in the g2 pharyngeal gland cells and vpi pharyngeal intestinal valve cells (PubMed:23932402, PubMed:25232734). Expressed in intestine (PubMed:24671950).
messages: Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif (PubMed:24671950). During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons (PubMed:23932402, PubMed:25232734, PubMed:26974341, PubMed:28846083). Together with chin-1 and cdc-42, plays a role in the development of the neuropil and is required for the guidance of axons from neurons, including SubL pioneer neurons and AIY interneurons, into the nerve ring (PubMed:28846083). Its role in axon guidance in glia and pioneer neurons may be through ensuring the fmi-1 protein is correctly localized to the nerve ring (PubMed:28846083). Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons (PubMed:23932402, PubMed:25232734, PubMed:26974341). In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance (PubMed:26974341). Also controls dendrite extension in AIY and D-type motoneurons, dendrite branching in AQR sensory neurons and VC4/5 motoneurons, the normal number of dendritic branches in AVL neurons and the positioning of HSN and ALM/PLM neurons (PubMed:25232734). Dispensable for maintaining dendrite branching in adults (PubMed:25232734). Also regulates dauer-specific dendritic branching of IL2 neurons and dauer-specific nictation behavior (PubMed:23932402). Under adverse environmental conditions, may promote dauer formation by processing insulin-like proteins ins-1 and ins-18, two daf-2/InsR antagonists (PubMed:24671950).
messages: Interacts (via extracellular domain) with receptor dma-1 (via extracellular domain); the interaction promotes dma-1 internalization.
messages: Perikaryon
messages: Several defects in neuron development (PubMed:25232734, PubMed:26974341). In PVD mechanosensory neurons, tertiary and quaternary branching is decreased, secondary and ectopic tertiary branching is increased, the length of dendritic branches is also reduced and branches tend to overlap (PubMed:25232734, PubMed:26974341). Secondary dendrite branches are trapped next to primary branches (PubMed:26974341). In a sax-7 (nj48) or dma-1 (wy686) mutant background, significantly less secondary dendrites are trapped (PubMed:26974341). Increased dma-1 protein levels in PVD neuron dendrites (PubMed:26974341). In addition, abnormal dendrite branches in FLP neurons, reduced axonal extension in AIY interneurons, abnormal positioning of touch receptor ALM and HSN motoneuron, formation of ectopic branching in AVL, loss of sensory AQR branching in the nerve ring, and impaired extension and formation of branches near the vulva in VC4/5 motoneurons (PubMed:26974341). RNAi-mediated knockdown at the L1 larval stage but not at the L4 larval stage causes defects in the dendritic branching of PVD neurons (PubMed:26974341).
messages: axon

6239:CELE ZK770.3
gene id: 6239:CELE_ZK770.3
uniprot id: O01634
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed in hyp8-11 tail tip cells during the L4 larval stage.
messages: RNAi-mediated knockdown causes defective oocyte transit through the spermatheca. Calcium oscillations triggered during ovulation are random resulting in uncoordinated spermatheca constrictions. Oocytes enter the spermatheca normally but change direction several times before returning into the gonad or proceeding into the uterus. RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209).
messages: Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca (PubMed:23671426). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: gap junction

6239:CELE F28H7.4
gene id: 6239:CELE_F28H7.4
uniprot id: Q19892
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. SELT subfamily.
messages: Cytoplasm
messages: Exclusively expressed in AWB chemosensory amphid neurons.
messages: Expressed from the L1 stage of larval development to adults.
messages: Perikaryon
messages: Probably has thioredoxin reductase-like oxidoreductase activity.
messages: Viable with normal development, anatomy, motility, lifespan and brood size. Double knockouts with selt-1.1 are also viable with no visible phenotype.
messages: axon
messages: dendrite

6239:CELE Y116F11B.12
gene id: 6239:CELE_Y116F11B.12
uniprot id: C6S3M5
uniprot id: Q8I136
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE R10D12.2
gene id: 6239:CELE_R10D12.2
uniprot id: Q9XVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZC455.5
gene id: 6239:CELE_ZC455.5
uniprot id: Q23335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y17G7B.12
gene id: 6239:CELE_Y17G7B.12
uniprot id: Q9XXI3
names: Similarity
messages: Belongs to the REXO4 family.

6239:CELE F11A10.6
gene id: 6239:CELE_F11A10.6
uniprot id: E1B6R9
uniprot id: Q9U3K1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F35F10.11
gene id: 6239:CELE_F35F10.11
uniprot id: Q9GYT5
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE ZK897.1
gene id: 6239:CELE_ZK897.1
uniprot id: Q23658
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Specifically required to activate the neuronal G-alpha pathway. Functions with G-alpha proteins from the same motor neurons to regulate locomotion (PubMed:16272411). Involved in regulating entry into quiescence triggered by satiety (PubMed:18316030). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142). Plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons (PubMed:22124329). Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271).
messages: Cytoplasmic vesicle membrane
messages: Synapse
messages: The PH domain is essential for regulated exocytosis and binds phospholipids.
messages: Within the ventral, dorsal and sublateral nerve cords, it is concentrated in cholinergic synapses. Within the ventral and dorsal nerve cords, it is not concentrated at most non-cholinergic synapses in the nerve cords, such as the GABAergic, glutamatergic, and catecholaminergic synapses. However, within the nerve ring, which contains a large number of interneuronal synapses in the head, it is clearly concentrated in regions containing large numbers of non-cholinergic synapses.
messages: Worms display increased adult life span and constitutive dauer formation (PubMed:10377425). RNAi-mediated knockdown in ADL sensory neurons results in reduced octopamine inhibition of the aversive response when animals are exposed to 100% 1-octanol (PubMed:22124329).

6239:CELE K08E5.3
gene id: 6239:CELE_K08E5.3
uniprot id: P34576
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed from the two-fold stage onwards.
messages: Expressed in the hypodermis at the sites of muscle contact, in striated muscles including body wall muscles, the anal sphincter muscles and the junctions between the anal sphincter muscle and rectal cuticle. Also expressed in non-muscle cells including the excretory duct cell and pore cells.
messages: Involved in cell adhesion and required for organ positioning and attachment (PubMed:25917920, PubMed:11470827, PubMed:11470828). At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton (PubMed:11470828).
messages: RNAi-mediated knockdown results in detached dorsal muscles and retracted ventral muscles from the anterior and posterior ends of the worm.
messages: hemidesmosome

6239:CELE F58A3.5
gene id: 6239:CELE_F58A3.5
uniprot id: Q93805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C28H8.12
gene id: 6239:CELE_C28H8.12
uniprot id: Q09248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunit 2 family.
messages: Membrane
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes (By similarity).
messages: Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3.
messages: centrosome
messages: cytoskeleton

6239:CELE C23G10.7
gene id: 6239:CELE_C23G10.7
uniprot id: Q45EK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

6239:CELE C54F6.7
gene id: 6239:CELE_C54F6.7
uniprot id: O16444
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE R10E11.3
gene id: 6239:CELE_R10E11.3
uniprot id: P34547
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Decreased levels of glr-1 in the ventral nerve cord and corresponding defects in glr-1-dependent behaviors including reduced spontaneous reversal frequency and reduced responsiveness to the nose touch assay which normally induces backward locomotion. Increased levels of ubiquitinated glr-1.
messages: Expressed in a number of tissues including the nervous system, pharynx, body wall muscle, vulva muscle and intestine and is detected in many head and ventral cord neurons.
messages: Interacts with wdr-20 and wdr-48; the catalytic activity of usp-46 is increased in the presence of both wdr-20 and wdr-48. Interacts with glr-1; the interaction results in deubiquitination of glr-1.
messages: Perikaryon
messages: Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity.

6239:CELE C03D6.5
gene id: 6239:CELE_C03D6.5
uniprot id: Q17603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

6239:CELE B0336.1
gene id: 6239:CELE_B0336.1
uniprot id: Q10953
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1 (PubMed:10380924). Within the complex, activates lit-1-dependent kinase activity (PubMed:10380924). Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329).
messages: Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233).
messages: Interacts (independently of ARM repeat) with nhr-25 (PubMed:16890160). Component of the beta-catenin-lit-1 complex (also called the lit-1/wrm-1 complex or the wrm-1/lit-1 kinase complex) at least composed of lit-1 and wrm-1 (PubMed:10380924, PubMed:15066285). Interacts (via N-terminus) with lit-1; the interaction is direct and activates lit-1 kinase activity which leads to the phosphorylation of pop-1 (PubMed:10380924, PubMed:11560894, PubMed:15066285). This promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm (PubMed:15066285).
messages: Nucleus
messages: Worms exhibit premature cell cleavage during embryogenesis, symmetrical cell division during gonadogenesis and undifferentiated intestines. Embryos show a defect in centrosome positioning that delays ABar spindle alignment and appear to lack endoderm.
messages: cell cortex

6239:CELE ZK637.7
gene id: 6239:CELE_ZK637.7
uniprot id: P30630
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-9 family.
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts with zft-11; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623).
messages: Decreased protein levels of DRM complex components including lin-37, lin-52 and lin-54 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514). RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246).
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein (PubMed:16678779, PubMed:17075059). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:17075059). Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad (PubMed:10974557). In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623).

6239:CELE T20F10.1
gene id: 6239:CELE_T20F10.1
uniprot id: O45797
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed at the embryonic comma stage and during all the larval stages and in adults.
messages: Expressed in muscles and epithelial tissues including pharynx, intestine and hypodermis (PubMed:19605499). Expressed in vulval and spermathecal seam cells (PubMed:19737560).
messages: Interacts (via N-terminus) with yap-1 (via WW domain).
messages: Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization (PubMed:23396260). Plays an essential role in larval development (PubMed:19737560, PubMed:19605499). Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway (PubMed:19737560). Does not appear to regulate apoptosis and proliferation (PubMed:19605499). In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage (PubMed:19737560). Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins (PubMed:19605499).
messages: RNAi-mediated knockdown results in larval lethality in 50 percent of the animals (PubMed:19737560, PubMed:19605499). Surviving knockdown animals have several defects including a slower growth and a partial distortion of the pharynx. In surviving L3 animals seam cells are 30 percent smaller (PubMed:19737560).

6239:CELE H20J04.8
gene id: 6239:CELE_H20J04.8
uniprot id: Q9BLB6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Interacts with rnp-3.
messages: Nucleus
messages: Reduced rate of growth. Embryonic lethal. Mog-2 and rnp-3 double mutants show arrested larval development at L2, without showing signs of oogenesis or spermatogenesis and increased rates of embryonic lethality.
messages: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing.

6239:CELE K11G12.6
gene id: 6239:CELE_K11G12.6
uniprot id: Q21435
uniprot id: Q2L6Y0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE T05G5.10
gene id: 6239:CELE_T05G5.10
uniprot id: G1K0V8
uniprot id: P34563
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Expressed specifically in the germline in the distal region of gonads where germ cells actively proliferate.
messages: Lys-54 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Present at late larval stages and adults.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules (PubMed:15003625).
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

6239:CELE H06O01.2
gene id: 6239:CELE_H06O01.2
uniprot id: O17909
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F39G3.8
gene id: 6239:CELE_F39G3.8
uniprot id: O16273
names: Similarity
messages: Belongs to the TGF-beta family.

6239:CELE T03E6.3
gene id: 6239:CELE_T03E6.3
uniprot id: Q9XU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F41D3.3
gene id: 6239:CELE_F41D3.3
uniprot id: O45507
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T10C6.3
gene id: 6239:CELE_T10C6.3
uniprot id: O45767
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in ASI sensory neurons.
messages: Insensitivity to ascaroside pheromones.
messages: Perikaryon
messages: Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior.
messages: cilium

6239:CELE Y105E8B.5
gene id: 6239:CELE_Y105E8B.5
uniprot id: Q9NF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

6239:CELE F14B4.2
gene id: 6239:CELE_F14B4.2
uniprot id: Q19440
names: Similarity
messages: Belongs to the hexokinase family.

6239:CELE F32B6.9
gene id: 6239:CELE_F32B6.9
uniprot id: O45435
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE W09C2.3
gene id: 6239:CELE_W09C2.3
uniprot id: G5EFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium across a membrane.
messages: Cell membrane
messages: Interacts with calmodulin.

6239:CELE Y54F10BM.14
gene id: 6239:CELE_Y54F10BM.14
uniprot id: G5EBY6
names: Similarity
messages: Belongs to the PHF5 family.

6239:CELE F26D2.14
gene id: 6239:CELE_F26D2.14
uniprot id: Q9XV58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y46G5A.26
gene id: 6239:CELE_Y46G5A.26
uniprot id: Q9U2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE T23B12.2
gene id: 6239:CELE_T23B12.2
uniprot id: O17005
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

6239:CELE F11F1.1
gene id: 6239:CELE_F11F1.1
uniprot id: G5EC99
uniprot id: H2FLI9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE C39E6.1
gene id: 6239:CELE_C39E6.1
uniprot id: Q18530
names: Similarity
messages: Belongs to the glypican family.

6239:CELE M142.4
gene id: 6239:CELE_M142.4
uniprot id: Q93899
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the even-skipped homeobox family.
messages: Embryo, L1 and L2 larvae.
messages: Nucleus
messages: Transcription factor (PubMed:28056346). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346). Probably acts by binding to specific promoter elements (PubMed:28056346). Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression (PubMed:8654927).

6239:CELE F38A3.2
gene id: 6239:CELE_F38A3.2
uniprot id: Q20136
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C06A8.6
gene id: 6239:CELE_C06A8.6
uniprot id: Q17692
names: Similarity
messages: Belongs to the SDS22 family.

6239:CELE Y67D8A.3
gene id: 6239:CELE_Y67D8A.3
uniprot id: Q95XU1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK899.4
gene id: 6239:CELE_ZK899.4
uniprot id: P52274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE F26G1.11
gene id: 6239:CELE_F26G1.11
uniprot id: A7LPC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y113G7A.4
gene id: 6239:CELE_Y113G7A.4
uniprot id: G5EF08
uniprot id: Q1RPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE Y102E9.2
gene id: 6239:CELE_Y102E9.2
uniprot id: G8XYY6
uniprot id: Q23232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

6239:CELE C52B9.4
gene id: 6239:CELE_C52B9.4
uniprot id: Q22938
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F32A6.5
gene id: 6239:CELE_F32A6.5
uniprot id: Q19958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: May be involved in cilia-related function.
messages: Membrane

6239:CELE F52D10.1
gene id: 6239:CELE_F52D10.1
uniprot id: G5EGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

6239:CELE T22A3.8
gene id: 6239:CELE_T22A3.8
uniprot id: G5ECE3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required to assemble a stable basement membrane and for organizing receptor complexes and cytoskeletal components to the proper cell surfaces (PubMed:12783803). During embryogenesis, does not require the presence of collagen type IV in order to associate with cell surfaces, prior to assembly of the prototypical basement membrane (PubMed:12783803). Plays an important role in muscle contraction of the body (PubMed:34723150). Probably plays a distinct role from the related laminin subunit alpha epi-1 (PubMed:12783803).
messages: First expressed between primary tissue layers near the end of gastrulation, at the 28-cell stage (at protein level) (PubMed:12783803). By the threefold stage of elongation, expression along the muscle quadrants declines and becomes restricted to a band at the center of each quadrant, which colocalizes with the dorsal and ventral sublateral nerve tracts in the adult (at protein level) (PubMed:12783803). High-level expression around the pharynx, pharyngeal intestinal valve, and intestine during morphogenesis (at protein level) (PubMed:12783803). In larvae and adults, expressed at high levels in the spermatheca and only weakly around the pharynx, the intestine and the excretory canal (at protein level) (PubMed:12783803). Expressed in the nervous system during elongation, and throughout the rest of development, at the nerve ring, a bundle of ~100 axons that encircles the outside of the pharynx, at the right fascicle of the ventral nerve cord and at the sublateral nerves (at protein level) (PubMed:12783803).
messages: Lacks detectable lam-3, but has no effect on tissue localization of laminin subunit alpha epi-1 (PubMed:12783803). Disrupted basement membrane integrity around pharynx in L1 stage larvae, causing structural disruption and abnormal localization of adherens junctions between pharyngeal cells (PubMed:12783803). RNAi-mediated knockdown causes arrest during early elongation or at the L1 larval stage (PubMed:12783803). L1 animals have abnormal pharyngeal development and have shorter bodies (posterior to the pharynx) at the time of arrest (PubMed:12783803). Simultaneous knockdown of laminin subunit alpha epi-1 increases likelihood of arrest during embryogenesis (PubMed:12783803).
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: Secreted
messages: Tissue-specific expression of the laminin alpha subunits lam-3 and epi-1 begins early, before or as organogenesis proceeds; furthermore, the tissue localization of the two alpha subunits are independent.
messages: basement membrane
messages: extracellular matrix
messages: extracellular space

6239:CELE T11F9.3
gene id: 6239:CELE_T11F9.3
uniprot id: Q22396
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C26E6.3
gene id: 6239:CELE_C26E6.3
uniprot id: Q18224
names: Subcellular Location Annotation
messages: P-body

6239:CELE ZK829.2
gene id: 6239:CELE_ZK829.2
uniprot id: P34751
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
messages: Homodimer.

6239:CELE K06A1.6
gene id: 6239:CELE_K06A1.6
uniprot id: Q10024
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

6239:CELE M117.1
gene id: 6239:CELE_M117.1
uniprot id: A0A061AE94
uniprot id: Q21538
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F20G4.3
gene id: 6239:CELE_F20G4.3
uniprot id: G5EBY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

6239:CELE T08G11.4
gene id: 6239:CELE_T08G11.4
uniprot id: A8WHU4
uniprot id: Q94013
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

6239:CELE Y71G12B.11
gene id: 6239:CELE_Y71G12B.11
uniprot id: G5EGK1
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE Y73F8A.30
gene id: 6239:CELE_Y73F8A.30
uniprot id: H2KML8
uniprot id: H2KML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F30B5.7
gene id: 6239:CELE_F30B5.7
uniprot id: Q19913
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12G3.8
gene id: 6239:CELE_T12G3.8
uniprot id: F5GUA1
uniprot id: Q95US5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 31 family.
messages: Expressed in the gut.
messages: Golgi apparatus membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796).
messages: Worms exhibit resistance to the Cry5B and Cry14A toxins produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry proteins.

6239:CELE F57A10.2
gene id: 6239:CELE_F57A10.2
uniprot id: O45592
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE R01H2.3
gene id: 6239:CELE_R01H2.3
uniprot id: Q21629
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (PubMed:16360684, PubMed:20971008). Redundantly with egg-1, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684). Conversely, shown to be dispensable for fertilization but required together with egg-1 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (PubMed:20971008). Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatase egg-3, and possibly egg-4 and egg-5 (PubMed:20971008).
messages: Severe sterility at the restrictive temperature of 25 degrees Celsius (PubMed:16360684). Accumulation of unfertilized oocytes in the uterus, although this is controversial (PubMed:16360684). Simultaneous RNAi-mediated knockdown with egg-1 results in a fragmented eggshell chitin layer which often accumulates at one end of the embryo (PubMed:20971008). In unfertilized oocytes, disrupts the homogenous distribution of cortical chitin synthase chs-1, pseudophosphatase egg-3 and kinase mbk-2 (PubMed:20971008). In a egg-1 (tm1071) mutant background, causes polyspermy (PubMed:20971008).

6239:CELE H06A10.2
gene id: 6239:CELE_H06A10.2
uniprot id: Q7YXA3
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K05F1.9
gene id: 6239:CELE_K05F1.9
uniprot id: Q21246
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE E03H4.5
gene id: 6239:CELE_E03H4.5
uniprot id: O17745
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F49F1.1
gene id: 6239:CELE_F49F1.1
uniprot id: Q9GZE5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F32D8.4
gene id: 6239:CELE_F32D8.4
uniprot id: Q19965
names: Similarity
messages: Belongs to the PIH1 family.

6239:CELE Y71H9A.3
gene id: 6239:CELE_Y71H9A.3
uniprot id: Q22165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

6239:CELE ZC84.1
gene id: 6239:CELE_ZC84.1
uniprot id: Q03610
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C14C10.6
gene id: 6239:CELE_C14C10.6
uniprot id: G5EEQ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in tissues including muscles, intestine and neurons.
messages: Hypersensitive to the acetylcholinesterase inhibitor aldicarb. In a slo-1 (ky399gf) gain of function mutant, restores normal locomotory speed and sensitivity to aldicarb.
messages: Promotes the translocation of slo-1 potassium ion channels from the endoplasmic reticulum to its final destination at the plasma membrane, probably by shielding from premature proteasomal degradation in the endoplasmic reticulum.
messages: dendrite

6239:CELE T05G5.4
gene id: 6239:CELE_T05G5.4
uniprot id: P34557
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0412.2
gene id: 6239:CELE_B0412.2
uniprot id: P92172
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Dauer-inducing pheromone inhibits its expression and promotes dauer formation, whereas food reactivates its expression and promotes recovery from the dauer state.
messages: Expressed in the chemosensory neurons, including in the ASJ neurons in males.
messages: Secreted
messages: Under harsh environmental conditions, larvae enter a developmentally arrested state known as dauer; TGF-beta-like daf-7 acts to inhibit dauer larva formation and promote growth (PubMed:8910282). May be a ligand to cell surface receptor daf-4 (PubMed:8413626). May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons (PubMed:8910282). Involved in sensitivity to CO2 levels (PubMed:18524955). Involved in mate searching behavior of males, acting in concert with the neuropeptide pdf-1 (PubMed:30024377). In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family (PubMed:20713521).
messages: When the food/pheromone ratio is high, its level peaks during the L1 larval stage (PubMed:8910282). Expression is detected in larvae beginning 4 to 5 hours after hatching, through the four larval stages, and in adults (PubMed:8910282). Expressed in ASJ chemosensory neurons in males from the L4 larval stage (PubMed:31264582).

6239:CELE C08B6.8
gene id: 6239:CELE_C08B6.8
uniprot id: Q17819
names: Function
names: Similarity
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.

6239:CELE ZK1128.4
gene id: 6239:CELE_ZK1128.4
uniprot id: Q09645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

6239:CELE T11G6.3
gene id: 6239:CELE_T11G6.3
uniprot id: Q22410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

6239:CELE Y43F4A.4
gene id: 6239:CELE_Y43F4A.4
uniprot id: O45930
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

6239:CELE K12D9.9
gene id: 6239:CELE_K12D9.9
uniprot id: P91384
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C03G6.12
gene id: 6239:CELE_C03G6.12
uniprot id: A0A131MB07
uniprot id: A0A131MB42
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C47G2.4
gene id: 6239:CELE_C47G2.4
uniprot id: Q18695
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

6239:CELE B0252.4
gene id: 6239:CELE_B0252.4
uniprot id: P52017
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE M02H5.1
gene id: 6239:CELE_M02H5.1
uniprot id: Q966H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C54C6.4
gene id: 6239:CELE_C54C6.4
uniprot id: Q18818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C16C2.1
gene id: 6239:CELE_C16C2.1
uniprot id: P20269
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R06C7.6
gene id: 6239:CELE_R06C7.6
uniprot id: Q21775
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
messages: Monomer.

6239:CELE C56E6.1
gene id: 6239:CELE_C56E6.1
uniprot id: D7SFK1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE E02H1.3
gene id: 6239:CELE_E02H1.3
uniprot id: Q09524
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer RNAs.

6239:CELE C06A8.9
gene id: 6239:CELE_C06A8.9
uniprot id: Q17697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

6239:CELE C48B4.4
gene id: 6239:CELE_C48B4.4
uniprot id: C0P274
uniprot id: P34358
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCA family.
messages: Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells.
messages: Membrane
messages: Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
messages: Ubiquitous in embryos. Expressed in larval germline precursors. Expression in larvae and adults is seen in amphid sheath cells, pharyngeal-intestinal valve and phasmid sheath cells. Low levels of expression are also seen in gonadal sheath cells.

6239:CELE C08C3.3
gene id: 6239:CELE_C08C3.3
uniprot id: P10038
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family.
messages: Defective QL neuroblast daughter cell migration (PubMed:8898225). Lin-39 and mab-5 double mutants have reduced sex myoblast specific expression of sem-2 in the developing mesoderm (PubMed:21307099).
messages: Expressed asymmetrically in the QL neuroblast.
messages: Nucleus
messages: Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration (PubMed:8898225, PubMed:23784779). During postembryonic development, required for posterior-specific pattern formation (PubMed:2903796). Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation (PubMed:2903796, PubMed:21307099).

6239:CELE M106.5
gene id: 6239:CELE_M106.5
uniprot id: P34686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

6239:CELE Y54E10BR.4
gene id: 6239:CELE_Y54E10BR.4
uniprot id: Q9N3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

6239:CELE F22B7.7
gene id: 6239:CELE_F22B7.7
uniprot id: P34410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F32G8.6
gene id: 6239:CELE_F32G8.6
uniprot id: A0A0H3W5N0
uniprot id: Q19980
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

6239:CELE F28B3.8
gene id: 6239:CELE_F28B3.8
uniprot id: Q9BIB8
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE C29E4.7
gene id: 6239:CELE_C29E4.7
uniprot id: P34345
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Omega family.
messages: Cytoplasm
messages: Exhibits glutathione-dependent thiol transferase activity (By similarity). Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid (By similarity). Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). Protects against environmental stress and oxidative stress (PubMed:17901115).
messages: Expressed in late embryos, during the L1 to L4 stages of larval development and in adult hermaphrodites.
messages: Expressed in the intestinal cells.
messages: Homodimer.
messages: RNAi-mediated knockdown results in increased sensitivity and reduced survival in response to oxidative stress inducers cumene hydroperoxide, jugalone, paraquat and arsenite, and to heat shock treatment.

6239:CELE F45E4.2
gene id: 6239:CELE_F45E4.2
uniprot id: Q94230
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Chromosome
messages: First expressed in blastomeres at the two cell stage of embryogenesis (PubMed:19084000). Also expressed in germline-specific P granules of early embryos (PubMed:19084000).
messages: Nucleus
messages: Probable transcription activator (PubMed:19084000). Binds telomeric DNA containing repeats of the sequence, 5'-TTAGGC-3' (PubMed:16267406). Binds to end-1 promoter, activating end-1 expression, which is required for endoderm specification during embryonic development (PubMed:19084000).
messages: Sterile due to lack of oocytes (PubMed:25439098). Defective locomotion, marked by a 3-fold reduction in speed (PubMed:25439098). RNAi-mediated knockdown causes embryonic lethality (PubMed:19084000). RNAi-mediated knockdown substantially reduces expression of end-1 (PubMed:19084000). RNAi-mediated knockdown abolishes formation of endoderm in 3% of embryos and in 35% of embryos on a mom-5 mutant background (PubMed:19084000).

6239:CELE F40G9.3
gene id: 6239:CELE_F40G9.3
uniprot id: Q9TZ69
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6239:CELE F41D3.1
gene id: 6239:CELE_F41D3.1
uniprot id: O45505
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C01H6.4
gene id: 6239:CELE_C01H6.4
uniprot id: Q17585
names: Similarity
messages: Belongs to the FMO family.

6239:CELE T25G3.2
gene id: 6239:CELE_T25G3.2
uniprot id: G5ECD6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family. Class IV subfamily.
messages: Cell membrane
messages: Essential for the embryonic synthesis of chitin, a component of the eggshell.
messages: Expressed at L3-L4 larval stages and in adults.
messages: RNAi-mediated knockdown causes the production of abnormal eggs characterized by a spherical morphology, the absence of the eggshell chitin layer, increased permeability to small molecules and a failure to divide (PubMed:16098962). Loss of polar body formation and loss of egg-3 and mbk-2 cortical localization in oocytes (PubMed:17869112). RNAi-mediated knockdown causes polyspermy in 40 percent of animals and a failure to internalize egg-1 after oocyte fertilization (PubMed:20971008). Simultaneous RNAi-mediated knockdown with mat-1 prevents the formation of the eggshell chitin layer (PubMed:20971008).

6239:CELE Y76A2B.6
gene id: 6239:CELE_Y76A2B.6
uniprot id: G5EBM7
names: Similarity
messages: Belongs to the CD36 family.

6239:CELE Y25C1A.11
gene id: 6239:CELE_Y25C1A.11
uniprot id: Q9TYL6
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F11G11.1
gene id: 6239:CELE_F11G11.1
uniprot id: P91254
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE F09F7.2
gene id: 6239:CELE_F09F7.2
uniprot id: P53014
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).

6239:CELE R53.2
gene id: 6239:CELE_R53.2
uniprot id: Q22018
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Catalyzes the conversion of dTMP to dTDP.

6239:CELE F29F11.6
gene id: 6239:CELE_F29F11.6
uniprot id: Q27497
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Interacts with lab-1; the interaction is direct.
messages: Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion (PubMed:11940606, PubMed:14622138). Dephosphorylates histone H3 at 'Ser-10' (PubMed:10975519). Dephosphorylates translation initiation factor eIF2alpha (PubMed:22719267). Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation (PubMed:12163466).

6239:CELE F55H2.5
gene id: 6239:CELE_F55H2.5
uniprot id: P34465
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: Putative transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles.

6239:CELE F25H2.6
gene id: 6239:CELE_F25H2.6
uniprot id: Q93569
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

6239:CELE ZK20.5
gene id: 6239:CELE_ZK20.5
uniprot id: Q23449
names: Disruption Phenotype
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S14 family.
messages: RNAi-mediated knockdown results in sterility.

6239:CELE ZK6.5
gene id: 6239:CELE_ZK6.5
uniprot id: O61868
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C52B9.7
gene id: 6239:CELE_C52B9.7
uniprot id: Q22943
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

6239:CELE Y51H1A.4
gene id: 6239:CELE_Y51H1A.4
uniprot id: Q9XWJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

6239:CELE Y47D3A.4
gene id: 6239:CELE_Y47D3A.4
uniprot id: Q9U2D2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C09H10.6
gene id: 6239:CELE_C09H10.6
uniprot id: Q17886
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NASP family.
messages: May interact with zinc finger protein tra-4 and histone deacetylase hda-1.
messages: Nucleus
messages: Promotes normal hermaphrodite (XX) development, in concert with zinc finger protein tra-4 and histone deacetylase hda-1, perhaps as components of a complex (PubMed:17011494). May act redundantly with nasp-2 (PubMed:17011494). Involved in innate immune response to B.thuringiensis strain DB27 and S.aureus bacteria (PubMed:23918784). May play a role in the uptake or spreading of dsRNA (PubMed:23918784).
messages: RNAi-mediated knockdown by injection leads to strong resistance to B. thuringiensis-mediated killing.

6239:CELE F52E1.10
gene id: 6239:CELE_F52E1.10
uniprot id: Q20666
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE T28F12.3
gene id: 6239:CELE_T28F12.3
uniprot id: Q9N5D3
names: Disruption Phenotype
names: Domain
names: Function
names: Subunit
messages: Interacts with cmd-1 in the presence of Ca(2+).
messages: Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23 (PubMed:10880441). Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation (PubMed:10880441, PubMed:17339331). Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development (PubMed:25371363). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870).
messages: RNAi-mediated knockdown results in 8% early larval lethality of the progeny. Surviving animals display slow growth, thin body morphology and both spermatogenesis and oogenesis are arrested at the pachytene stage of meiosis I. In addition, males have short and crumpled spicules. RNAi-mediated knockdown prevents multi-vulva induction in let60 n1046, let-23 sa62 or lin-15 n765 mutants and fluid accumulation in clr-1 e1745ts mutant.
messages: The DH (DBL-homology) domain may inhibit the Ras-GEF domain, thereby preventing excessive let-60/Ras activation.

6239:CELE Y39A1C.4
gene id: 6239:CELE_Y39A1C.4
uniprot id: G5EDG9
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6239:CELE B0281.8
gene id: 6239:CELE_B0281.8
uniprot id: O16616
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which catalyzes 'Lys-48'-linked polyubiquitination of ced-1, promoting its proteasomal degradation to maintain appropriate ced-1 levels for apoptotic cell clearance (PubMed:35929733). Acts together with E2 ubiquitin-conjugating enzyme ubc-21 (PubMed:35929733).
messages: In early larva, observed mainly in pharyngeal and body wall muscle cells.
messages: Interacts with E2 ubiquitin-conjugating enzyme ubc-21 (PubMed:35929733). Interacts with ced-6; this mediates interaction of trim-21 with ced-1 and is required for ced-1 ubiquitination (PubMed:35929733). Interacts with nck-1; the interaction is required for ced-1 ubiquitination (PubMed:35929733).
messages: RNAi-mediated knockdown results in increased levels of ced-1.
messages: The coiled coil is required for interactions with ced-1, ced-6 and ubc-21.

6239:CELE F17C11.9
gene id: 6239:CELE_F17C11.9
uniprot id: P54412
names: Disruption Phenotype
names: Function
names: PTM
names: Subunit
messages: AMPylated by fic-1.
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.
messages: RNAi-mediated knockdown results in 100% sterility at 25 degrees Celsius.

6239:CELE F37H8.1
gene id: 6239:CELE_F37H8.1
uniprot id: O17862
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in FLP neurons.
messages: In the presence of polyglutamine, mislocalizes to the cytosol and loses its transcriptional regulation activity, but is able to promote protein aggregation.
messages: Nucleus
messages: Positively regulates the RNA polymerase III-associated transcription of small non-coding RNAs.

6239:CELE T08G11.1
gene id: 6239:CELE_T08G11.1
uniprot id: Q8T3D2
uniprot id: Q94010
names: Similarity
messages: Belongs to the VPS13 family.

6239:CELE C05E4.3
gene id: 6239:CELE_C05E4.3
uniprot id: G5EE40
names: Similarity
messages: Belongs to the serpin family.

6239:CELE F43D2.1
gene id: 6239:CELE_F43D2.1
uniprot id: O17869
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE K03D7.11
gene id: 6239:CELE_K03D7.11
uniprot id: Q9XUV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y37B11A.3
gene id: 6239:CELE_Y37B11A.3
uniprot id: Q9BKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE Y37E3.5
gene id: 6239:CELE_Y37E3.5
uniprot id: H2L0N8
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. Required for normal sensory cilium function. May act by maintaining the association between IFT subcomplexes A and B.
messages: Monomer.
messages: Shortened cilia with various ultrastructural deformities and a disrupted association between IFT subcomplexes A and B.
messages: Specifically expressed in ciliated sensory neurons throughout development in both hermaphrodites.
messages: Sumoylation regulates the targeting of membrane sensory receptors to the cilium.
messages: The RVVP region and palmitoylation sites are required for compartmentalization inside cilium to prevent distal cilium and nuclear targeting.
messages: cilium membrane

6239:CELE F58E6.5
gene id: 6239:CELE_F58E6.5
uniprot id: Q20981
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZC506.4
gene id: 6239:CELE_ZC506.4
uniprot id: A0A0K3ASV1
uniprot id: A0A0K3AWH7
uniprot id: A3FPK2
uniprot id: Q09630
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity).
messages: Membrane

6239:CELE M01G12.9
gene id: 6239:CELE_M01G12.9
uniprot id: O62317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE T13A10.11
gene id: 6239:CELE_T13A10.11
uniprot id: Q27522
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Protein expression is regulated by post-transcriptional regulation: under rich-diet conditions, mett-10 binds and methylates sams-5 mRNA, directly inhibiting splicing and protein production of S-adenosylmethionine synthase.

6239:CELE C43H6.6
gene id: 6239:CELE_C43H6.6
uniprot id: A8WFK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F11C1.7
gene id: 6239:CELE_F11C1.7
uniprot id: G1K0W6
uniprot id: G1K0W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

6239:CELE ZK688.3
gene id: 6239:CELE_ZK688.3
uniprot id: P34673
names: Function
names: Similarity
messages: Belongs to the FAH family.
messages: May have hydrolase activity.

6239:CELE F54D1.4
gene id: 6239:CELE_F54D1.4
uniprot id: Q20765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R04B5.6
gene id: 6239:CELE_R04B5.6
uniprot id: Q21703
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE T22C8.5
gene id: 6239:CELE_T22C8.5
uniprot id: Q22678
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Expressed during the larval L1 to adult stages, with little or no change in transcript levels (PubMed:24569038). Expressed in several head neurons during L4 larval stage in hermaphrodites (PubMed:24569038).
messages: RNAi-mediated knockdown causes hypodermal or cuticular rupture, typically in the anterior body region (PubMed:24569038). Abnormal gap between the outer layer of hypodermis and muscle and the internal organs, perhaps due to defects in cuticle integrity (PubMed:24569038).
messages: Transcription factor (By similarity). Probably acts downstream of the Wnt signaling pathway (PubMed:24569038).

6239:CELE K12C11.4
gene id: 6239:CELE_K12C11.4
uniprot id: O44997
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Beginning in the L3 stage, animals display striking and progressive defects in morphology of the epidermis and cuticle in several body regions, particularly in the nose, tail, vulva, and the dorsal midline in the region of the posterior pharyngeal bulb (PubMed:19164535, PubMed:27661253). The cuticle in these regions becomes up to 5-10 times thicker than the wild-type, at the expense of underlying epidermis (PubMed:19164535, PubMed:27661253). Up-regulates innate immune responses to damage (PubMed:19164535). Decreases starvation-induced autophagy (PubMed:17785524). Disorganization and hyper-stabilization of epidermal microtubules and reduced microtubule growth rates (PubMed:27661253). Treatment with a microtubule stabilizing drug, paclitaxel, results in enhanced epidermal morphology defects (PubMed:27661253). In a ptrn-1 mutant background, suppression of the epidermal morphology defects (PubMed:27661253).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
messages: Expressed in epidermis, muscles and neurons.
messages: Interacts with ptrn-1.
messages: Negative regulator of epidermal barrier repair and innate immune responses to wounding (PubMed:19164535, PubMed:27661253). The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1 (PubMed:27661253). In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA (PubMed:28087624). Appears to act downstream of or in parallel to muscarinic signaling in the regulation of autophagy (PubMed:17785524).
messages: Present from late embryogenesis onwards.
messages: cytoskeleton
messages: cytosol

6239:CELE K11G9.5
gene id: 6239:CELE_K11G9.5
uniprot id: Q23012
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK1320.9
gene id: 6239:CELE_ZK1320.9
uniprot id: Q09657
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

6239:CELE F44C8.4
gene id: 6239:CELE_F44C8.4
uniprot id: O16359
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE M163.11
gene id: 6239:CELE_M163.11
uniprot id: Q564X4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K11G9.6
gene id: 6239:CELE_K11G9.6
uniprot id: P17511
names: Domain
names: Function
names: Induction
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 6 family.
messages: By cadmium.
messages: This protein binds cations of several transition elements.

6239:CELE F54C9.6
gene id: 6239:CELE_F54C9.6
uniprot id: Q20755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE K06H6.4
gene id: 6239:CELE_K06H6.4
uniprot id: O17105
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F18E2.3
gene id: 6239:CELE_F18E2.3
uniprot id: Q19555
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication (PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Plays an essential role in cell division during embryonic development (PubMed:12808038, PubMed:14560015, PubMed:12827206, PubMed:16802858). Required for the assembly of the synaptonemal complex between homologous chromosomes to promote sister chromatid cohesion during mitosis and meiosis (PubMed:14499625, PubMed:14560015). Has a role in stabilization of homologous chromosome associations during meiotic synapsis (PubMed:12827206). Required for chromosome segregation during mitosis and meiosis (PubMed:14499625, PubMed:12808038, PubMed:14560015, PubMed:16802858). Plays a role in DNA double-strand break (DSB) repair during meiotic recombination and promotes the assembly of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, at DNA damage sites (PubMed:21856158).
messages: Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their hinge domain, scc-1 which links them, and scc-3 (PubMed:12827206). Interacts with scc-1, smc-1 and tim-1 (PubMed:12827206).
messages: Expressed in gonadal cells.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:14560015, PubMed:12827206, PubMed:12808038, PubMed:16802858). RNAi-mediated knockdown from early in larval development results in sterile, uncoordinated (Unc), and protruding vulva phenotypes, in abnormal embryonic cell nuclei morphology and in defects in the mitotic and meiotic cells of gonads (PubMed:14499625, PubMed:14560015). RNAi-mediated knockdown results in somatic gonad cell division defects with a reduced number of pi uterine cells at the early- to mid-L4 larval stage (PubMed:14560015). RNAi-mediated knockdown results in chromosome segregation defects in early embryos with lagging chromosomes at the anaphase phase of mitosis (PubMed:14499625, PubMed:12808038, PubMed:16802858). RNAi-mediated knockdown results in defective homologous alignment of chromosomes and chromosome cohesion in meiosis (PubMed:14499625).

6239:CELE Y57G11C.46
gene id: 6239:CELE_Y57G11C.46
uniprot id: Q7YTI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE F22E10.5
gene id: 6239:CELE_F22E10.5
uniprot id: G5EC09
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

6239:CELE T25C12.1
gene id: 6239:CELE_T25C12.1
uniprot id: Q21446
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asynchrony between gonadal and vulval development. Retarded uterine uv1 cell differentiation (PubMed:19161245). RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including impaired egg-laying and production of ectopic seam cells (PubMed:25432023). RNAi-mediated knockdown reduced the number of dauer animals in a dcap-1 mutant background (PubMed:28250105).
messages: Cleaved by caspase ced-3 in vitro.
messages: Despite no sequence similarity in conventional searches, based on an AlphaFold predicted structure, the sequence-specific DNA-binding region exhibits structural homology to known BEN domains, for example in human BEND3 and fruit-fly protein insensitive insv.
messages: Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of various genes, including insulin/insulin-like growth factor gene ins-33 and neuropeptide-encoding gene nlp-45 (PubMed:16314527, PubMed:36977380). Binds to the consensus sequence 5'-[CT]GGA[AG]-3' in the regulatory elements of target genes (PubMed:16314527, PubMed:36977380). Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008). Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153). Plays a role in promoting survival at high temperatures in larvae (PubMed:28250105). Involved in maintenance of the architecture of the ventral nerve cord, perhaps acting via modulating expression of the immunoglobulin domain gene zig-4.
messages: High levels in hypodermal, intestinal, body wall muscle, nerve ring, and ventral nerve cord cells of embryos and L1 animals.
messages: May be involved in specifying L1 cell fates.
messages: May specify L2 and later cell fates, creating a temporal switch.
messages: Nucleus
messages: Present at high levels in embryos and L1 animals but is undetectable at later stages.

6239:CELE T22E7.2
gene id: 6239:CELE_T22E7.2
uniprot id: Q9N5D8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F56H6.5
gene id: 6239:CELE_F56H6.5
uniprot id: O45583
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Expressed throughout development.

6239:CELE F58A4.14
gene id: 6239:CELE_F58A4.14
uniprot id: Q5CZ52
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS4 family.
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). May be required for microtubule anchoring at the centrosome but not for microtubule nucleation (By similarity). May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity). Required, redundantly with bbs-5, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:22922713, PubMed:26150102). Plays a role in the removal of degraded mechanosensory receptors within the cilia (PubMed:26150102).
messages: Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity). Interacts (via C-terminus) with bbs-5; the interaction is direct (PubMed:26150102).
messages: Single mutants do not display any obvious defects in ciliogenesis. Double bbs-4 and bbs-5 mutants display a defect in cilia structure and function. This is characterized by an increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins along the ciliary axoneme. Double mutants also have defective polycystin-mediated cilia signaling and mislocalized and increased accumulation of mechanosensory receptors pkd-2, osm-9 and odr-10 within cilia.
messages: centrosome
messages: cilium membrane
messages: cytoskeleton

6239:CELE T24B8.5
gene id: 6239:CELE_T24B8.5
uniprot id: Q22714
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C06E7.1
gene id: 6239:CELE_C06E7.1
uniprot id: P50305
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Protein expression is regulated by post-transcriptional regulation: under rich-diet conditions, mett-10 binds and methylates sams-3 mRNA, directly inhibiting splicing and protein production of S-adenosylmethionine synthase.

6239:CELE F11C1.2
gene id: 6239:CELE_F11C1.2
uniprot id: Q19343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

6239:CELE ZK185.5
gene id: 6239:CELE_ZK185.5
uniprot id: Q3V5H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE T12A2.9
gene id: 6239:CELE_T12A2.9
uniprot id: P46565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE Y59E9AR.3
gene id: 6239:CELE_Y59E9AR.3
uniprot id: Q9N2K7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Alters embryonic vab-7 expression pattern.
messages: Involved in the regulatory network to control embryonic patterning and morphogenesis. Implicated in negatively regulating vab-7 expression at the anterior of embryos.
messages: Nucleus

6239:CELE F10D2.9
gene id: 6239:CELE_F10D2.9
uniprot id: G5EGH6
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Cytochrome b5 CYTB-5.1 is specifically required for the desaturase activity, its knockdown or mutation alters the enzyme activity.
messages: Delta(9)-fatty acid desaturase that acts preferentially on stearoyl-CoA (octadecanoyl-CoA) producing the monounsaturated oleoyl-CoA ((9Z)-octadecenoyl-CoA), one of the most abundant monounsaturated fatty acid in Caenorhabditis elegans phospholipids and triacylglycerols (PubMed:16839188, PubMed:10872837, PubMed:29237573). Also acts on palmitoyl-CoA (hexadecanoyl-CoA), heptadecanoyl-CoA and (11E)-octadecenoyl-CoA (trans-vaccenoyl-CoA), the monounsaturated fatty acids (MUFAs) produced are further used by several other desaturases and elongases as substrates to synthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes) (PubMed:16839188, PubMed:10872837, PubMed:29237573). Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity). Partially inhibits expression of genes involved in beta-oxidation, such as ech-1 and acs-2, perhaps signaling via the actions of one of its fatty acid products (PubMed:15719061). May form part of a negative feedback loop with the transcription factor nhr-49 to limit beta-oxidation, in which nhr-49 stimulates expression of fat-7 and acs-2, and in turn fat-7 indirectly inhibits acs-2 and other genes also involved in beta-oxidation (PubMed:15719061).
messages: Expressed in the intestine in adult worms and in all four larval stages.
messages: Expression is regulated by nhr-80 and nhr-49.
messages: Membrane
messages: RNAi-mediated knockdown causes a significant increase in the abundance of C18:0 fatty acid, as well as a decrease in the levels of C18:1n9 and C18:2n6 fatty acids (PubMed:15719061). Slight reduction in polyunsaturated fatty acids (PUFAs) (PubMed:15719061). Widespread vacuole formation, germ line necrosis and shortened life-span (PubMed:15719061).
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

6239:CELE T11A5.7
gene id: 6239:CELE_T11A5.7
uniprot id: Q5WRN5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK525.2
gene id: 6239:CELE_ZK525.2
uniprot id: O46024
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y116A8C.38
gene id: 6239:CELE_Y116A8C.38
uniprot id: Q9U2T8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C27A12.5
gene id: 6239:CELE_C27A12.5
uniprot id: G5ECT8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EMX homeobox family.
messages: Can substitute for ems in D.melanogaster ems mutants, partially rescuing the mutant phenotype.
messages: Earliest expression is detected in late gastrulation (at protein level). Expression is strongest in elongated embryos and early larvae.
messages: In the anterior pharynx, expressed in the I3 interneuron, the NSM and M3 motor neuron pairs, the three m2 muscle cells and the three e2 epithelial cells (at protein level).
messages: Mutants lacking the homeobox domain are viable and fertile but proliferate slightly more slowly than wild-type due to retarded larval development and reduced brood size. About 20% appear starved as they are shorter, thinner and paler at all stages with severely affected adults bearing only a few eggs. M3 neuron activity is decreased.
messages: Nucleus
messages: Required for activity of the M3 pharyngeal motor neuron.

6239:CELE T22F3.4
gene id: 6239:CELE_T22F3.4
uniprot id: A0A131MBQ6
uniprot id: Q94300
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Mutants have an extended lifespan, increased volume and are sterile with a germ cell proliferation defect.
messages: Nucleus
messages: There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.

6239:CELE F09E5.3
gene id: 6239:CELE_F09E5.3
uniprot id: Q19264
names: Function
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.

6239:CELE C01B4.9
gene id: 6239:CELE_C01B4.9
uniprot id: A0A0M7RDR8
uniprot id: A0A0M7RFF6
uniprot id: Q9UAT3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F13B9.8
gene id: 6239:CELE_F13B9.8
uniprot id: Q6AHP8
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network (By similarity). Involved in perinuclear clustering of the mitochondrial network (By similarity). May act, redundantly with fis-1, downstream of mitochondrial fission, before the fission products participate in mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Plays a role in apoptosis by promoting mitochondrial elimination and cell-death execution, acting downstream of caspase ced-3, and perhaps independently of dynamin GTPase drp-1, caspase ced-9 and apoptosis-inducing factor AIFM/wah-1 (PubMed:18722182).
messages: Mitochondrial connectivity appears normal and also normal in a fis-1 mutant background (PubMed:18722182). Abnormal, but minor, affects on apoptosis, with fewer cell corpses and an increase in cell numbers in a caspase ced-3, ced-4, or dynamin GTPase drp-1 mutant background (PubMed:18722182). Increases number of ectopic cells in a combined ced-3 and drp-1 mutant background (PubMed:18722182). Increases number of ectopic cells in a combined ced-3; ced-9 mutant background, which increases further in a ced-3; ced-9; drp-1 mutant background (PubMed:18722182). Larger number of mitochondria, and little reduction in mitochondria area index, in cell corpses in a ced-1 mutant background (PubMed:18722182).
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Peroxisome membrane
messages: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission.

6239:CELE T09D3.6
gene id: 6239:CELE_T09D3.6
uniprot id: Q86B34
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F56G4.5
gene id: 6239:CELE_F56G4.5
uniprot id: Q9TW67
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Double knockout with rpt-5 RNAi results in failed expression of the proteasomal subunit rpt-3.
messages: Endoplasmic reticulum
messages: Inhibited by Zn(2+) and z-VAD-fmk (caspase inhibitor) but unaffected by EDTA.
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation (PubMed:17509531, PubMed:17522090). Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp (PubMed:17522090). Prefers proteins containing high-mannose over those bearing complex type oligosaccharides (PubMed:17522090). Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins (PubMed:17509531). Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (PubMed:17509531). Also displays oxidoreductase (thioredoxin) activity (PubMed:17509531, PubMed:17522090). Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction (PubMed:27528192).

6239:CELE F16H11.4
gene id: 6239:CELE_F16H11.4
uniprot id: P53547
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK757.4
gene id: 6239:CELE_ZK757.4
uniprot id: G5ECT4
uniprot id: G5EDL2
uniprot id: G5EG19
uniprot id: Q8I0G4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F21H12.1
gene id: 6239:CELE_F21H12.1
uniprot id: Q09309
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2.
messages: Expressed widely during early embryogenesis (PubMed:21698137). Expression is significantly reduced throughout the embryo after formation of the ASE neurons (PubMed:21698137). Expressed in the maternal germline (PubMed:21698137).
messages: Nucleus
messages: Required for di- and trimethylation at 'Lys-4' of histone H3. Regulates left/right asymmetry of ASE sensory neurons, via its role as a component of the SET2 complex (PubMed:21698137).
messages: Strongly reduced di- and trimethylation at 'Lys-4' of histone H3 in embryos and adult germline stem cells. Mutants also display defects in egg laying and fertility with defective germ cell development. RNAi-mediated knockdown disrupts development of the ASE left (ASEL) neuron, causing it to adopt the ASE right (ASER) cell fate (PubMed:21698137).

6239:CELE ZC190.4
gene id: 6239:CELE_ZC190.4
uniprot id: O76699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

6239:CELE T14F9.1
gene id: 6239:CELE_T14F9.1
uniprot id: Q22494
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE R06F6.5
gene id: 6239:CELE_R06F6.5
uniprot id: Q09601
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Expressed in embryos (at protein level).
messages: Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (PubMed:35852146). Thereby required for nuclear import (PubMed:35852146). Required for the proper organization of chromosomes on the mitotic spindle during anaphase (PubMed:28122936).
messages: Nucleus membrane
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:12937276, PubMed:28122936). Reduces nuclear import and diameter of pronuclei prior to pseudocleavage regression (PubMed:35852146). Embryos show an abnormal distribution of nuclear pore complexes and patchy nuclear envelope assembly (PubMed:35852146). Also causes severe defects in mitosis due to abnormal chromosome organization on the mitotic spindle during anaphase (PubMed:28122936). Two-cell embryos appear to lack nuclei and pronuclei.
messages: nuclear pore complex

6239:CELE Y48G8AL.13
gene id: 6239:CELE_Y48G8AL.13
uniprot id: Q9BL09
uniprot id: W6RR25
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y56A3A.32
gene id: 6239:CELE_Y56A3A.32
uniprot id: K8ESD4
uniprot id: Q9U229
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

6239:CELE F35G2.4
gene id: 6239:CELE_F35G2.4
uniprot id: Q20065
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P4HA family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen
messages: Heterotetramer of two alpha chains and two beta chains. Exist either as a phy-2(2)/pdi-2(2) tetramer or as a phy-1/phy-2/pdi-2(2) tetramer.

6239:CELE Y71H2AM.20
gene id: 6239:CELE_Y71H2AM.20
uniprot id: Q9BL35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE ZK131.5
gene id: 6239:CELE_ZK131.5
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C55B6.1
gene id: 6239:CELE_C55B6.1
uniprot id: H2KZG4
names: Similarity
messages: Belongs to the FGGY kinase family.

6239:CELE C11E4.1
gene id: 6239:CELE_C11E4.1
uniprot id: Q93204
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE F37F2.2
gene id: 6239:CELE_F37F2.2
uniprot id: O61749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity).
messages: Cytoplasm
messages: nucleolus

6239:CELE D2021.1
gene id: 6239:CELE_D2021.1
uniprot id: A0A131MBT2
uniprot id: A0A131MCP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

6239:CELE Y75B12B.10
gene id: 6239:CELE_Y75B12B.10
uniprot id: Q86DA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZC204.5
gene id: 6239:CELE_ZC204.5
uniprot id: P91536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srh family.
messages: Membrane

6239:CELE ZK131.9
gene id: 6239:CELE_ZK131.9
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y18H1A.12
gene id: 6239:CELE_Y18H1A.12
uniprot id: V6CLD0
uniprot id: V6CLE3
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE T02B5.1
gene id: 6239:CELE_T02B5.1
uniprot id: O01302
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE K12G11.3
gene id: 6239:CELE_K12G11.3
uniprot id: Q17334
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Homotetramer.

6239:CELE C14H10.1
gene id: 6239:CELE_C14H10.1
uniprot id: Q17996
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C41D11.9
gene id: 6239:CELE_C41D11.9
uniprot id: Q95QZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

6239:CELE C50C3.9
gene id: 6239:CELE_C50C3.9
uniprot id: P34374
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Decendants of the cells AB and AB.p (that give rise to nearly all non-pharyngeal neurons), decendants of P1 (that give rise to body muscle) and cell lineages that give rise to the adult and juvenile motor neurons. Expressed in body wall, vulval muscle and pharyngeal muscle.
messages: May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization-induced calcium influx and pharyngeal pumping (PubMed:8462849, PubMed:8807295, PubMed:16838374). Involved in restricting the expression of the putative olfactory receptor str-2 to only one of the two AWC neurons (PubMed:10571181).
messages: Membrane
messages: Worms exhibit a weak egg-laying constitutive (Egl-c) phenotype and slow irregular pharyngeal pumping.

6239:CELE C34D4.1
gene id: 6239:CELE_C34D4.1
uniprot id: Q18452
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme

6239:CELE D2007.4
gene id: 6239:CELE_D2007.4
uniprot id: P34378
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE C14C11.6
gene id: 6239:CELE_C14C11.6
uniprot id: Q17978
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE Y39G8B.4
gene id: 6239:CELE_Y39G8B.4
uniprot id: Q9U2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F08G2.6
gene id: 6239:CELE_F08G2.6
uniprot id: Q9XVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE K10C2.3
gene id: 6239:CELE_K10C2.3
uniprot id: Q94271
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C34C12.3
gene id: 6239:CELE_C34C12.3
uniprot id: Q09496
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic subunit of protein phosphatase 6 (PP6) (By similarity). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning (PubMed:20040490). Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5 (PubMed:20040490).
messages: Cytoplasm
messages: Expressed in embryos.
messages: Forms a complex composed of catalytic subunit pph-6 and regulatory subunit saps-1; the interaction increases pph-6 and saps-1 protein stability.
messages: RNAi-mediated knockdown causes lethality in 17 percent of animals. In the 1-cell embryo, cortical contractions are severely reduced and the pseudocleavage furrow is absent. Positioning of the spindle is abnormal due to reduced pulling forces that prevent oscillatory movements of the posterior spindle pole during anaphase. In 15 percent of animals, causes defects in chromosome segregation resulting in daughter cells with multiple nuclei.
messages: cell cortex
messages: cytoskeleton
messages: spindle pole

6239:CELE K10B4.5
gene id: 6239:CELE_K10B4.5
uniprot id: O17240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE W07E6.4
gene id: 6239:CELE_W07E6.4
uniprot id: G5ECL3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y43H11AL.1
gene id: 6239:CELE_Y43H11AL.1
uniprot id: A0A0K3AR60
uniprot id: A0A0K3AUR6
uniprot id: A0A0K3AX31
uniprot id: H2L057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

6239:CELE Y71F9AL.1
gene id: 6239:CELE_Y71F9AL.1
uniprot id: Q9N4H1
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

6239:CELE T04A8.11
gene id: 6239:CELE_T04A8.11
uniprot id: Q22140
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

6239:CELE T07C4.8
gene id: 6239:CELE_T07C4.8
uniprot id: P41958
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abundant expression is seen in embryos and adults (PubMed:7907274). Expressed in embryos prior to elongation, at comma stage, at 1.5-fold stage and in adult gonad (PubMed:17021039).
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:19327994). However, another study shows that ced-9 is involved in regulating mitochondrial dynamics (PubMed:21949250).
messages: Endomembrane system
messages: Interacts with asymmetric homodimer ced-4; the interaction sequesters ced-4 (PubMed:9024666, PubMed:9027313, PubMed:15383288, PubMed:16208361). Interacts with egl-1; the interaction results in ced-4 release (PubMed:9604928, PubMed:12894216, PubMed:15383288). Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly (PubMed:23431138). Interacts with dct-1 (PubMed:11114722). May form a complex composed of ced-9, ced-4 and mac-1 (PubMed:10101135). Interacts with dynamin-related protein drp-1 (via residues 280-502); the interaction is enhanced by GTP rather than GDP; the interaction is probably direct and may occur at the mitochondrion (PubMed:21949250). Interaction with drp-1 may be enhanced by interaction of ced-9 with egl-1, but not with ced-4 (PubMed:21949250). A ced-9/egl-1 complex may recruit drp-1 to the mitochondrial surface (PubMed:21949250). Interacts with fzo-1; interaction may be suppressed by interaction of ced-9 with egl-1 (PubMed:21949250).
messages: Mitochondrion membrane
messages: Perikaryon
messages: Plays a major role in programmed cell death (PCD, apoptosis) (PubMed:7907274, PubMed:10688797). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9024666, PubMed:9027313, PubMed:9604928, PubMed:12894216, PubMed:15383288, PubMed:16208361). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway (PubMed:26074078). Has been shown in one study to be dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:19327994). However, another study shows that a egl-1/ced-9 containing complex may promote drp-1-dependent mitochondrial fission (PubMed:21949250).
messages: Synapse

6239:CELE Y52B11A.8
gene id: 6239:CELE_Y52B11A.8
uniprot id: Q9U256
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to the phospholipase A2 family, it lacks the conserved active Asp in position 129, which is replaced by a Val residue, suggesting that it has no activity.
messages: Belongs to the phospholipase A2 family.
messages: Secreted

6239:CELE Y48B6A.4
gene id: 6239:CELE_Y48B6A.4
uniprot id: Q9U298
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping (PubMed:15020415, PubMed:8601480). Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (PubMed:8462849, PubMed:9789046, PubMed:15141086, PubMed:28853436, PubMed:30965033). Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine (PubMed:30965033).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Expressed in pharyngeal muscle.
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.
messages: Postsynaptic cell membrane
messages: Worms exhibit a lack of MC neurotransmission possibly explaining the observed reduction in pharyngeal pumping rate (PubMed:15020415). Mutants show differences in their pharyngeal responses to nicotine (PubMed:15020415). A variety of mutants show an increase in lifespan ranging from 29-57% longer than wild-type (PubMed:15141086, PubMed:28853436). Extended self-fertile reproductive span, fast body movement, and a longer pharyngeal pumping span (PubMed:15141086). The strongest allele (ad1113) shows retarded growth (PubMed:15141086). Animals generally have smaller nucleoli (PubMed:28853436). Double knockout with ncl-1 reduces the increased longevity and suppresses the reduced nucleoli size phenotype of the eat-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436).

6239:CELE R10D12.1
gene id: 6239:CELE_R10D12.1
uniprot id: Q9XVK0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M03F4.3
gene id: 6239:CELE_M03F4.3
uniprot id: Q23013
uniprot id: Q2L6V9
uniprot id: Q7JNP9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE Y10G11A.1
gene id: 6239:CELE_Y10G11A.1
uniprot id: E4MYG2
uniprot id: Q95ZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

6239:CELE Y37A1C.1
gene id: 6239:CELE_Y37A1C.1
uniprot id: E9P897
uniprot id: E9P898
uniprot id: G5EEQ4
uniprot id: G5EFE5
uniprot id: H8ESD4
uniprot id: H8ESD5
uniprot id: L8E912
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C31B8.8
gene id: 6239:CELE_C31B8.8
uniprot id: G5EBU3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Inhibited by human TIMP1 and TIMP2 and the broad MMP inhibitors BB94 (Batimastat) and CT543.
messages: Metalloproteinase.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

6239:CELE Y17D7A.3
gene id: 6239:CELE_Y17D7A.3
uniprot id: O45907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R06C7.5
gene id: 6239:CELE_R06C7.5
uniprot id: Q21774
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (Probable).

6239:CELE C06G3.2
gene id: 6239:CELE_C06G3.2
uniprot id: G5EBX0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE F08B4.6
gene id: 6239:CELE_F08B4.6
uniprot id: Q966W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable).
messages: Golgi apparatus membrane
messages: Monomer.
messages: Present in some specific neurons in head and tail regions and muscles.

6239:CELE R01H2.5
gene id: 6239:CELE_R01H2.5
uniprot id: G5EER4
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Expressed throughout larval development and in adults.

6239:CELE F20C5.4
gene id: 6239:CELE_F20C5.4
uniprot id: Q19635
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

6239:CELE F55B12.3
gene id: 6239:CELE_F55B12.3
uniprot id: Q93794
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in tail and head neurons.
messages: Expression begins at the 50-cell embryonic stage and continues throughout development (PubMed:19528325). Expressed in the HSNL motor neuron from early larval stage L4 to the young adult stage (PubMed:17626846).
messages: Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex which includes skr-1 and F-box domain-containing protein sel-10 as a substrate recognition component (PubMed:17626846). Interacts with fem-1, fem-2, and fem-3 (PubMed:15306688). Interacts with the intracellular domain of glp-1 and sel-12 (PubMed:9861048). Interacts with lin-12 (PubMed:9389650). Interacts with skr-1 (PubMed:18718460). Interacts with zyg-1 (PubMed:22623721).
messages: Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983).
messages: Worms show a weak masculinization phenotype (PubMed:8293978). Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants (PubMed:8293978). RNAi-mediated knockdown results in increased zyg-1 expression at centrosomes (PubMed:22623721).
messages: axon

6239:CELE F27C1.7
gene id: 6239:CELE_F27C1.7
uniprot id: Q7JNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

6239:CELE W01B6.1
gene id: 6239:CELE_W01B6.1
uniprot id: P34889
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Anterior displacement of the nerve ring in L1 stage mutant animals (PubMed:19855022). Defective ALM, BDU, CAN and QR neuroblast migration and irregular CP and CAN axon growth and guidance (PubMed:16109397). Double knockout with cfz-2 results in enhanced CAN migration defects, but the same QR neuroblast migration defects as the single cfz-2 knockout alone (PubMed:16109397). Double knockout with cwn-1 results in ALM, CAN and HSN migration defects (PubMed:16109397, PubMed:16516839). Triple knockout with cwn-1 and cfz-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Belongs to the Wnt family.
messages: Expressed at the comma stage in pharyngeal muscles and the developing intestine (PubMed:19855022). Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). At the two-fold stage of embryogenesis, mainly it is expressed in the intestine (PubMed:20711352). During late embryogenesis, before hatching, it is expressed in the posterior pharyngeal bulb and the pharyngeal-intestine (PubMed:20711352). After the L1 stage of larval development it is expressed in the anterior part of the animal in tissues including the pharynx, body wall muscle and ventral cord neurons (PubMed:20711352).
messages: Expressed in intestine, pharynx, anterior body wall muscle, vulva, some pharyngeal neurons and SMD head neurons (PubMed:19855022, PubMed:19561603, PubMed:22022276). Expressed along the boundary between the intestine and muscle or hypodermis, but is also expressed in the hypodermis in cells including seam cells (PubMed:22022276).
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1 (PubMed:19855022). In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore (PubMed:19855022). Together with Wnt ligand cwn-1, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). May act through the wnt receptor cfz-2 to regulate QR neuroblast descendant migration, and to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with wnt ligand cwn-1, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Through the cam-1 receptor also probably regulates the outgrowth of neurites from RME GABAergic motor neurons (PubMed:20711352). May act redundantly with other Wnt ligands such as cwn-1 and mom-2 to control seam cell polarity (PubMed:22022276).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE Y53F4B.18
gene id: 6239:CELE_Y53F4B.18
uniprot id: Q9NAB7
names: Similarity
messages: Belongs to the amidase family.

6239:CELE F56E3.4
gene id: 6239:CELE_F56E3.4
uniprot id: G5EDJ0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Expressed in embryonic and postembryonic neurons, including AVKR and AVKL interneurons (at protein level) (PubMed:10648229, PubMed:16183052). Expressed in the AVA, AVB, and AVE bilateral interneuron pairs, the RIC bilaterally-paired interneurons, SIBD and either SIBV or SMBV neuron pairs, M4 motorneuron, and the unpaired DVA interneuron (at protein level) (PubMed:16183052). Expressed dynamically in two non-neuronal cell types during larval development, paired distal tip cells (DTCs) of the hermaphrodite somatic gonad of L2 through L4 stage larvae and two pairs of vulval cells in L4 hermaphrodite larvae (at protein level) (PubMed:16183052). Expressed in the pairs of CEPD and URX sensory neurons, three pharyngeal neurons (M1, MI and probably M5), two pairs of ring interneurons (including the RIC pair), five neurons in the retrovesicular ganglion (including SABD and the pair of SABV neurons), a single neuron in the preanal ganglion and a single neuron in the dorsorectal ganglion of the tail (PubMed:10648229). Not expressed in either of the HSN or PVQ neurons, or in the PVPR neuron at any stage of development (PubMed:10648229).
messages: Nucleus
messages: Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3' (PubMed:10648229, PubMed:18179707). Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes (PubMed:10648229, PubMed:16183052, PubMed:9216999, PubMed:22690911). Involved in specifying interneuron identity, in concert with paired-like homeodomain unc-42 (PubMed:16183052). Plays a role in recognition of the PVPR and PVQL axons by the AVKR and HSNL growth cones (PubMed:9216999).
messages: Putative ligand binding domain (NR LBD) may be dispensable for import into nuclei and in the development of neurons that control movement.
messages: axon

6239:CELE H38K22.3
gene id: 6239:CELE_H38K22.3
uniprot id: Q9XXA7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein.
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 136 and 169.

6239:CELE K07C5.5
gene id: 6239:CELE_K07C5.5
uniprot id: G5EDL5
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME).
messages: Less active when compared to ceeh-1.
messages: RNAi knockdown of both ceeh-1 and ceeh-2 results in the accumulation of 9,10-EpOME and 12,13-EpOME.

6239:CELE C50B6.8
gene id: 6239:CELE_C50B6.8
uniprot id: P91983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK970.1
gene id: 6239:CELE_ZK970.1
uniprot id: G5ED52
uniprot id: G5EDC4
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE C33H5.9
gene id: 6239:CELE_C33H5.9
uniprot id: Q18406
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE F28A12.4
gene id: 6239:CELE_F28A12.4
uniprot id: Q22972
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE T07C4.9
gene id: 6239:CELE_T07C4.9
uniprot id: Q27512
uniprot id: Q7JMT5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6239:CELE C10G8.1
gene id: 6239:CELE_C10G8.1
uniprot id: Q94168
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE ZC204.2
gene id: 6239:CELE_ZC204.2
uniprot id: P91547
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F21A3.6
gene id: 6239:CELE_F21A3.6
uniprot id: O17824
names: Similarity
messages: Belongs to the globin family.

6239:CELE D1054.15
gene id: 6239:CELE_D1054.15
uniprot id: G5ECP2
uniprot id: G5EEL2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

6239:CELE C27C7.4
gene id: 6239:CELE_C27C7.4
uniprot id: G5EGP2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F33H2.2
gene id: 6239:CELE_F33H2.2
uniprot id: O62219
names: Similarity
messages: Belongs to the FAM91 family.

6239:CELE C56A3.2
gene id: 6239:CELE_C56A3.2
uniprot id: Q18878
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE ZK256.1
gene id: 6239:CELE_ZK256.1
uniprot id: G5EDU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE K05F1.5
gene id: 6239:CELE_K05F1.5
uniprot id: Q21241
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LECT2/MIM-1 family.
messages: Cell junction
messages: Cell surface
messages: Component of a multi-protein dma-1 receptor-ligand complex, which is activated upon binding of lect-2, mnr-1 and sax-7 ligands to promote the morphogenesis of dendrites which extend from the PVD neuronal body (PubMed:27705746). Within the complex interacts with sax-7; the interaction is required for lect-2 dendritic localization and enhances the binding of the mnr-1 and sax-7 ligands to the dma-1 receptor-ligand complex (PubMed:27705746).
messages: Expressed in body wall muscle cells, along the boundary of the lateral hypodermis, seam cells, processes of the nervous system including commissures, sensory dendrites in the head, and lateral nerve tracts, and motor neurons and some mechanosensory neurons such as ALM.
messages: Expressed throughout development (PubMed:27451901). Diffusely expressed from the gastrula stage to the 3-fold embryonic stage (PubMed:27451901). In larvae, expressed in hypodermal tissues and processes of the nervous system, including commissures, sensory dendrites in the head, and lateral nerve tracts (PubMed:27451901). In L3 and L4 stage larvae, mainly expressed in body wall muscles, and it is also expressed in head neurons and ventral nerve cord neurons (PubMed:27705746).
messages: Muscle-derived dendritic guidance cue, which is required for the formation of somatosensory dendritic arbors which extend from PVD and FLP sensory neurons during development (PubMed:27451901). Ligand of a multi-protein dma-1 receptor-ligand complex, which is activated upon binding of lect-2, mnr-1 and sax-7 ligands to control the growth of dendrites that extend anteriorly from the PVD neuronal cell body (PubMed:27451901, PubMed:27705746). Enhances the binding of the mnr-1 and sax-7 ligands to the dma-1 receptor-ligand complex (PubMed:27705746). Restricts the growth of secondary PVD dendritic branches and any irregularly positioned ectopic tertiary dendritic branches that originate from secondary branches, and promotes the formation of stable higher order dendritic branches (PubMed:27451901, PubMed:27705746). In particular, it is required for the formation of quaternary PVD dendritic branches and promotes their innervation of body wall muscles (PubMed:27705746). Promotes self-avoidance of tertiary dendritic branches of PVD sensory neurons (PubMed:27451901). Not required for the growth of dendrites that extend from AIY and PVQ interneurons, DVB GABergic neurons, PLM and ALM mechanosensory neurons, AFD sensory neurons and DD/VD and DA/DB motor neurons (PubMed:27451901).
messages: Perikaryon
messages: Secreted
messages: basement membrane
messages: dendrite

6239:CELE F35G12.4
gene id: 6239:CELE_F35G12.4
uniprot id: Q20059
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat WDR48 family.
messages: Changed locomotion behavior with mutants displaying decreased reversal frequencies consistent with decreased glutamergic signaling.
messages: Expressed in several head neurons and cells in the tail including the anal depressor cell.
messages: Interacts with usp-46; the interaction increases the catalytic activity of usp-46 in the presence of wdr-20.
messages: Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.

6239:CELE C48B6.6
gene id: 6239:CELE_C48B6.6
uniprot id: O01510
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Component of a post-splicing multiprotein NMD complex.
messages: Cytoplasm
messages: Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.

6239:CELE F58G6.7
gene id: 6239:CELE_F58G6.7
uniprot id: Q95QD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Late endosome membrane
messages: Membrane

6239:CELE R173.4
gene id: 6239:CELE_R173.4
uniprot id: Q8MPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Secreted

6239:CELE F54D7.4
gene id: 6239:CELE_F54D7.4
uniprot id: O44730
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in body wall muscles.
messages: No visible phenotype (PubMed:19737747, PubMed:22829780). No defect in the positioning of ASI and ASH neuron cell bodies (PubMed:22829780). No defect in the positioning of PQV, PVP, RMEV, HSN adn AVK axons in the ventral nerve cord (PubMed:19737747).
messages: Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
messages: Secreted

6239:CELE K04G2.3
gene id: 6239:CELE_K04G2.3
uniprot id: Q21222
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression (PubMed:15716356, PubMed:18854144). Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC) (PubMed:18854144). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit (PubMed:18854144). Controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion (PubMed:15716356).
messages: Belongs to the AAA ATPase family. AFG2 subfamily.
messages: Cytoplasm
messages: Homohexamer; ATP binding induces oligomerization (By similarity). Forms a ring-shaped particle of about 12 nm diameter, that displays 6-fold radial symmetry (By similarity). Interacts (via N-terminus) with kinase air-2; the interaction is direct and inhibits air-2 kinase activity in an ATPase-dependent manner.
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:15716356, PubMed:18854144). The first embryonic cell divisions have mitotic spindle and chromosome segregation defects, and mitotic progression is significantly delayed (PubMed:18854144). At late telophase/G1, air-2 accumulates at the spindle midbody abnormally persisting following cleavage furrow ingression and into the next mitotic cycle (PubMed:18854144). Loss of inhibition of air-2 kinase activity (PubMed:18854144). Also, causes defects in ER dynamics characterized by a failure of the ER to form a sheet structure at the onset of mitosis and remains in large aggregates throughout mitosis (PubMed:15716356). In an air-2 (os207) mutant background, which lacks air-2 catalytic activity, restores normal mitosis and thus embryonic viability (PubMed:18854144).
messages: The first ATP-binding region binds ATP with low affinity whereas the second ATP-binding region binds ATP with high affinity.

6239:CELE C32D5.12
gene id: 6239:CELE_C32D5.12
uniprot id: Q09491
names: Similarity
messages: Belongs to the 3-beta-HSD family.

6239:CELE F59G1.3
gene id: 6239:CELE_F59G1.3
uniprot id: Q21053
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

6239:CELE F55B12.4
gene id: 6239:CELE_F55B12.4
uniprot id: Q93795
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

6239:CELE Y43C5A.5
gene id: 6239:CELE_Y43C5A.5
uniprot id: F3Y5P8
names: Similarity
messages: Belongs to the thymidine kinase family.

6239:CELE T28F3.1
gene id: 6239:CELE_T28F3.1
uniprot id: Q9XUB9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the copine family.
messages: C2 domains are necessary for calcium-dependent cell membrane association. C2 domains are necessary for neuronal progenitor cell differentiation in a calcium-independent manner.
messages: Cell membrane
messages: Exhibits calcium-dependent phospholipid binding properties (By similarity). May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord (PubMed:15990870). Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole (PubMed:15990870). Affects directional sperm motility (PubMed:16998478).
messages: Expressed in head and tail neurons, ventral cord moto-neurons, body wall muscles and hypodermal cells of the vulva.
messages: Interacts with nicotinic acetylcholine receptor.
messages: Sperm directional motility defects (PubMed:16998478). RNAi-mediated knockdown causes a moderate resistance to nicotine-induced paralysis and a decrease in unc-38 synaptic expression along nerve cords without affecting lev-1 cellular expression levels in muscles (PubMed:15990870).

6239:CELE Y34D9A.4
gene id: 6239:CELE_Y34D9A.4
uniprot id: G5ED58
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

6239:CELE R04F11.3
gene id: 6239:CELE_R04F11.3
uniprot id: Q21730
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T01C8.5
gene id: 6239:CELE_T01C8.5
uniprot id: Q22067
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate (PubMed:29649217). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system (PubMed:29649217).
messages: Cytoplasm
messages: Expressed in all somatic tissues including the nervous system.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE C34C6.3
gene id: 6239:CELE_C34C6.3
uniprot id: Q18424
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C48E7.11
gene id: 6239:CELE_C48E7.11
uniprot id: Q8IG69
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Expressed broadly in somatic tissues including the intestine.
messages: Interacts with transcription factor zip-11.
messages: Nucleus
messages: RNAi-mediated knockdown reduces overall fat content (PubMed:26505800). Decreases survival upon infection with P.aeruginosa (PubMed:26876169, PubMed:28662060). Reduces induction of expression of infection response gene, irg-1, in response to P.aeruginosa (PubMed:26876169). The decrease in survival upon P.aeruginosa infection on a zip-11 mutant background is abolished by RNAi-mediated knockdown of cebp-2.
messages: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Regulates expression of genes involved in fat metabolism, including ech-1.1 and fat-5 (PubMed:26505800). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:26876169, PubMed:28662060, PubMed:34804026). Required for the activation of infection response gene irg-1 following P.aeruginosa infection (PubMed:26876169). Required to prevent P.aeruginosa ToxA-mediated lethality (PubMed:26876169). May also function in concert with transcription factor zip-11 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026). May act together with the bZIP transcription factor, zip-2 (PubMed:26876169).

6239:CELE F40F11.2
gene id: 6239:CELE_F40F11.2
uniprot id: A6ZJ71
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: During gonad development, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody which allows for the formation of gonad arms. Role in gonad DTC migration may be in association with integrin related proteins ina-1 and mig-15.
messages: Embryonic lethal. RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis. RNAi-mediated knockdown specifically in gonad DTCs also result in a DTC migration defect in which DTCs migrate away from the hermaphrodite midbody on the dorsal basement membrane. RNAi-mediated knockdown in a unc-6 mutant background results in failed gonad DTC migration to the midbody of the hermaphrodite. RNAi-mediated knockdown with ina-1, mig-15 or talin in an rrf-3 mutant background results in enhanced gonad DTC migration.
messages: Expressed in gonad distal tip cells and gonad sheath cells.
messages: Expressed in somatic gonad precursors Z1 and Z4 in the gonad primordium and later in distal tip cells during the larval stages.
messages: Nucleus

6239:CELE K08B12.5
gene id: 6239:CELE_K08B12.5
uniprot id: A0A0K3AUZ7
uniprot id: O01583
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: Expressed in embryonic and L4 larval seam cells and in embryonic dorsal and ventral epidermal cells. Also expressed in the pharynx throughout development and in sublateral nerve cords in the L4 larva.
messages: Normal adult development, but progeny arrest at either the L1 stage or during embryogenesis (PubMed:19675126). RNAi-mediated knockdown causes excretory canal truncation, abnormal lumen and cyst formation. In addition, causes a reduced distribution of Golgi and ER components along the excretory canal length and a decrease in cdc-42 activation (PubMed:25743393).
messages: Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation (PubMed:19675126). Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation (PubMed:25743393).

6239:CELE F22D6.3
gene id: 6239:CELE_F22D6.3
uniprot id: Q19722
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress.

6239:CELE Y51H4A.9
gene id: 6239:CELE_Y51H4A.9
uniprot id: Q9NAE0
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE M05B5.5
gene id: 6239:CELE_M05B5.5
uniprot id: G5EEG9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: During male tail development, expressed in each of the nine Rn cells and in the anterior daughter cell, the ray neuroblast (at protein level) (PubMed:11076762). First expressed at the comma stage of embryogenesis (PubMed:19632181). Expressed asymmetrically, in the mother cell of the MI pharyngeal motorneuron but not in the mother cell of the e3D epithelial cell (PubMed:21041366). Expressed during hermaphrodite gonadogenesis, in the two somatic gonadal progenitor (SGP) cells, Z1.ppp and Z4.aaa, precursors to the anchor cell (AC) and the ventral uterine precursor cell (VU), but not detected in their sister cells, Z1.ppa and Z4.aap (PubMed:14701877, PubMed:19376107, PubMed:21784067). Expressed in both pre-AC and pre-VU cells, and after the AC/VU decision, expression is reduced in the VU and its descendants; however, expression persists in the AC through the time of basement membrane invasion (PubMed:21784067, PubMed:31402303). Expressed in the gonadal distal tip cells (DTCs) throughout development and in adults (PubMed:19376107).
messages: Interacts with helix-loop-helix protein ngn-1; the interaction is direct (PubMed:21041366). Efficient DNA binding probably requires dimerization with another helix-loop-helix protein (PubMed:19632181, PubMed:11076762). Forms a heterodimer with helix-loop-helix protein hlh-12 (PubMed:17588558). Forms a heterodimer with lin-32 (PubMed:11076762). May form a heterodimer with hlh-10 (PubMed:19632181).
messages: Nucleus
messages: RNAi-mediated knockdown in the early larval L1 stage causes both somatic gonadal progenitor (SGP) cells, Z1.ppp and Z4.aaa, to assume the ventral uterine precursor cell (VU) identity; whereas, if RNAi is applied during the late larval L1 stage, or at the larval L2 stage, both assume the anchor cell (AC) identity (PubMed:21784067, PubMed:14701877). RNAi-mediated knockdown applied at the time of the larval stage L1/L2 molt causes defects in invasion of the basement membrane by the AC (PubMed:21784067). RNAi-mediated knockdown causes the MI pharyngeal motorneuron to transform into an e3D-like epithelial cell (PubMed:21041366). RNAi-mediated knockdown reduces expression of alpha integrin ina-1 and of ADAMTS protease gon-1, and causes defects in migration of the gonadal distal tip cells (DTCs) (PubMed:25982859, PubMed:17588558). RNAi-mediated knockdown causes reduction in the number of hermaphrodites with DTCs, diminishes formation of elongated gonadal arms and reduces expression of lag-2 (PubMed:19376107). RNAi-mediated knockdown during larval stage L3 causes a subsequent three-fold reduction in germ cell number in the adult hermaphrodite gonad (PubMed:19376107). RNAi-mediated knockdown increases lifespan, reduces fertility, improves the response to proteotoxic stress, alters the response to reactive oxygen species (ROS) and reduces expression of arginine kinases such as argk-1 (PubMed:32203922).
messages: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:19632181, PubMed:11076762, PubMed:14701877). Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision; required for VU fate (PubMed:14701877, PubMed:31402303). Regulates expression of lin-12/Notch receptor and putative ligand lag-2 in the presumptive AC and presumptive VU cells (PubMed:31402303). Modulates expression of lag-2 in the gonadal distal tip cells (DTCs) (PubMed:14701877, PubMed:19376107). Involved in formation of the polarised cell membrane of the AC and thus facilitates invasion across the gonadal basement membrane, acting via transcriptional modulation of multiple genes (PubMed:21784067). Involved in specification of the hermaphrodite DTC and the male linker cell, perhaps acting in concert with the homeobox protein, ceh-22 (PubMed:19376107). Plays a role in regulation of migration of DTCs and the modulation of expression of alpha integrin ina-1 and ADAMTS protease gon-1 (PubMed:25982859, PubMed:17588558). Required for DTC maintenance, and for function of the DTC as a niche for germline stem cells (PubMed:19376107). Plays a role in cell-autonomously establishing a neuronal left-right asymmetry (PubMed:21041366). Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:11076762). Negatively modulates lifespan, perhaps acting by regulating expression of arginine kinases, which in turn results in altered metabolism and homeostasis of reactive oxygen species (ROS) (PubMed:32203922).

6239:CELE F39F10.2
gene id: 6239:CELE_F39F10.2
uniprot id: Q20193
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE Y24F12A.1
gene id: 6239:CELE_Y24F12A.1
uniprot id: N1NTK1
uniprot id: Q9U2Q7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6239:CELE Y71H2AM.22
gene id: 6239:CELE_Y71H2AM.22
uniprot id: Q9BL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE W08D2.5
gene id: 6239:CELE_W08D2.5
uniprot id: F5GUA7
uniprot id: Q27533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

6239:CELE C54D1.1
gene id: 6239:CELE_C54D1.1
uniprot id: Q18824
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F09F3.9
gene id: 6239:CELE_F09F3.9
uniprot id: G5EG54
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE Y59H11AR.2
gene id: 6239:CELE_Y59H11AR.2
uniprot id: Q86FP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

6239:CELE F07A5.1
gene id: 6239:CELE_F07A5.1
uniprot id: O62136
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE R10E12.1
gene id: 6239:CELE_R10E12.1
uniprot id: P34552
names: Developmental Stage
names: Function
messages: Expressed throughout development.
messages: Required for lin-12 degradation after it has been internalised in the vulval precursor cells.

6239:CELE K02D7.5
gene id: 6239:CELE_K02D7.5
uniprot id: O45102
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Mediates both low-affinity uptake and efflux of sugar across the membrane.

6239:CELE C41D11.3
gene id: 6239:CELE_C41D11.3
uniprot id: A0A078BPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

6239:CELE Y18H1A.14
gene id: 6239:CELE_Y18H1A.14
uniprot id: Q1EPL6
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C10C5.5
gene id: 6239:CELE_C10C5.5
uniprot id: Q17900
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

6239:CELE F16H9.1
gene id: 6239:CELE_F16H9.1
uniprot id: P49808
names: Disruption Phenotype
names: Function
names: PTM
names: Tissue Specificity
messages: Expressed in a subset of neurons including ventral cord and head- and tail-ganglia neurons. Also expressed in non-neuronal cells including pharyngeal and uterine muscles.
messages: May be phosphorylated and activated by egl-4.
messages: RNAi-mediated knockdown in ASH sensory neurons results in hypersensitivity to dilute quinine.
messages: Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior (PubMed:10950865). Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons (PubMed:23874221).

6239:CELE B0041.7
gene id: 6239:CELE_B0041.7
uniprot id: Q9U7E0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Expressed in most cells during embryonic development (PubMed:15328017, PubMed:15649460). First expressed at around the 100-200 cell stage of embryogenesis (PubMed:15328017, PubMed:15649460). Expression was absent or reduced in intestinal cell lineages during this time. Highly expressed in neuronal cells of the head, ventral nerve cord and tail during the late stages of embryogenesis (PubMed:15328017). Highly expressed in all dividing cells after hatching (PubMed:15649460). Highly expressed in the P lineage during the L1 stage of larval development (PubMed:15649460). During larval development, mainly expressed in the neurons, but there is also high expression in the junctional cells of the spermatheca and uterus, and weak expression in cells of the somatic gonad including the distal tip cells (PubMed:15328017).
messages: Nucleus
messages: Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development.
messages: Temperature-sensitive with 38% embryonic lethality at 25 degrees Celsius (PubMed:15649460). A large proportion of surviving animals are sterile. Surviving animals also have gonad developmental defects such as defective gonadal arm growth and as a result irregular distal tip cell migration, and 24% of animals had a protruding vulva phenotype (PubMed:15649460). Reduced brood size (PubMed:15328017). Double knockout with lin-35 results in 43% embryonic lethality (PubMed:15328017). Surviving animals develop slowly, are small, sterile and display male and female gonad developmental defects characterized by shorter gonadal arms, fewer germ cells, an everted vulva phenotype, and failed formation of sheath and spermathecal cells (PubMed:15328017). RNAi-mediated knockdown of lin-35 or hpl-2 results in larval arrest at 25 degrees Celsius in an xpn-1 mutant background (PubMed:15649460).

6239:CELE T23C6.1
gene id: 6239:CELE_T23C6.1
uniprot id: O02042
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE B0222.7
gene id: 6239:CELE_B0222.7
uniprot id: Q17459
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE C15B12.5
gene id: 6239:CELE_C15B12.5
uniprot id: Q18007
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Expressed in head region of the larva. In adults, expression is seen in the periventricularis magnocellularis (PVM) neuron.
messages: Expressed throughout development from embryonic to adult stage, highest level seen in early larvae. Isoform A is the most abundant and isoform C is the least.
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

6239:CELE F26H11.5
gene id: 6239:CELE_F26H11.5
uniprot id: O45405
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Expressed in the intestine, neurons and muscles.
messages: Golgi apparatus membrane
messages: Lysosome membrane
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Membrane
messages: Probable chloride channel.

6239:CELE C48E7.9
gene id: 6239:CELE_C48E7.9
uniprot id: Q8IG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F23H11.8
gene id: 6239:CELE_F23H11.8
uniprot id: G5EBX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family.
messages: Binds 2 manganese ions per subunit.
messages: Cell membrane
messages: Expression is restricted to neurons. Expressed in AWB, AWC, AVA, AVB, AVX, BAG and URX neurons and in one tail neuron (at protein level).
messages: Perikaryon
messages: Probably acts as a protein phosphatase.
messages: axon
messages: cilium
messages: dendrite

6239:CELE Y48B6A.5
gene id: 6239:CELE_Y48B6A.5
uniprot id: Q9U2A7
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F25H9.7
gene id: 6239:CELE_F25H9.7
uniprot id: E1B6U7
uniprot id: P91989
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

6239:CELE Y54E2A.1
gene id: 6239:CELE_Y54E2A.1
uniprot id: G5EDR6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F19B6.1
gene id: 6239:CELE_F19B6.1
uniprot id: Q9U3I7
names: Similarity
messages: Belongs to the uridine kinase family.

6239:CELE C06G8.3
gene id: 6239:CELE_C06G8.3
uniprot id: A7LPH3
uniprot id: Q6BEU0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H02I12.8
gene id: 6239:CELE_H02I12.8
uniprot id: G5EGT6
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE E01A2.4
gene id: 6239:CELE_E01A2.4
uniprot id: Q966L6
names: Similarity
messages: Belongs to the NKAP family.

6239:CELE Y49E10.6
gene id: 6239:CELE_Y49E10.6
uniprot id: Q9U281
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Highly expressed in nearly all larval and adult nuclei. Expressed only at low levels in intestine. Expressed throughout all stages of gametogenesis.
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: Present at all embryonic stages (at protein level).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

6239:CELE C34F6.2
gene id: 6239:CELE_C34F6.2
uniprot id: O17641
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y4C6B.6
gene id: 6239:CELE_Y4C6B.6
uniprot id: Q9UB00
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

6239:CELE C25H3.7
gene id: 6239:CELE_C25H3.7
uniprot id: Q8MQC1
names: Similarity
messages: Belongs to the FAX family.

6239:CELE Y48E1B.3
gene id: 6239:CELE_Y48E1B.3
uniprot id: B7WNB0
uniprot id: O18197
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

6239:CELE ZK1236.1
gene id: 6239:CELE_ZK1236.1
uniprot id: P34617
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE C17C3.7
gene id: 6239:CELE_C17C3.7
uniprot id: Q18054
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed postembryonically at all larval and adult stages, including the developmentally arrested larval state known as dauer stage (PubMed:26438299). Expressed in neurons of the head and tail, including the motor neurons VD1, DA3, and DA7 (PubMed:26438299). Also expressed in the anal depressor muscle, anterior and posterior intestinal cells, and the head and body wall muscles (PubMed:26438299). Expressed in the PDE sensory neuron pairs and rare, transient expression seen in migrating distal tip cells of larval L3/L4 stages (PubMed:26438299).
messages: Hermaphrodites produce fewer live progeny at 20 degrees Celsius than wild-type, and also laying more unfertilized oocytes throughout the egg-laying period (PubMed:26438299). Abnormal gonad morphology (PubMed:26438299). Delayed recovery from the developmentally arrested larval state known as dauer (PubMed:26438299). Significantly longer lifespan (PubMed:26438299). Decreased movement (PubMed:26438299). RNAi-mediated knockdown causes an increase in daf-18 transcripts (PubMed:26438299).
messages: Nucleus
messages: Probable transcription factor (PubMed:26438299). Modulates lifespan and also recovery from the developmentally arrested larval state known as dauer, perhaps acting upstream of phosphatase PTEN/daf-18 (PubMed:26438299). Regulates expression of genes involved in cell division, cell-cycle regulation, and sexual reproduction, including daf-18 (PubMed:26438299).

6239:CELE F56B3.11
gene id: 6239:CELE_F56B3.11
uniprot id: H2L085
uniprot id: Q9TXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE T27F2.4
gene id: 6239:CELE_T27F2.4
uniprot id: Q22835
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Negatively regulated by the microRNA mir-60 (PubMed:27623524, PubMed:29664006). Induced in response to thermal stress in conditions where severe cold temperatures are followed by warmer temperatures (PubMed:29664006).
messages: Nucleus
messages: RNAi-mediated knockdown reduces the lifespan extension phenotype of the mir-60 loss of function mutant.
messages: Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals.

6239:CELE B0491.7
gene id: 6239:CELE_B0491.7
uniprot id: Q17514
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

6239:CELE F49C12.8
gene id: 6239:CELE_F49C12.8
uniprot id: Q20585
names: Function
names: Similarity
names: Tissue Specificity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S10 family.
messages: Expressed in multiple tissues including the intestine, pharynx and hypodermis.

6239:CELE F59F5.6
gene id: 6239:CELE_F59F5.6
uniprot id: Q21049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the liprin family. Liprin-alpha subfamily.
messages: Detected in vulval muscle and other cells near the vulva; in neurons located in the lateral ganglion, posterior ganglion, ventral cord and lateral body; and in pharyngeal and body wall muscle cells.
messages: May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:10517634, PubMed:19290026). This may be in association with the liprin-beta protein hlb-1 (PubMed:19290026).
messages: Synapse

6239:CELE Y22D7AL.10
gene id: 6239:CELE_Y22D7AL.10
uniprot id: Q965Q1
names: Similarity
messages: Belongs to the GroES chaperonin family.

6239:CELE F48D6.2
gene id: 6239:CELE_F48D6.2
uniprot id: H2KZD8
uniprot id: Q5DX32
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F01D4.4
gene id: 6239:CELE_F01D4.4
uniprot id: O17754
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: During FMRFamide-like peptide (FaRPs or FLP) and neuropeptide-like protein (NLP) precursor processing, catalyzes the removal of Arg or Lys residues from the C-terminus following the initial endoprotease cleavage (PubMed:17564681, PubMed:12657671). By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions (PubMed:12657671, PubMed:22275875). Involved in egg-laying, defecation and locomotion (PubMed:11813735, PubMed:17564681, PubMed:22275875). By processing FLP neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271). Involved in reducing pharyngeal pumping in response to high CO(2) levels (PubMed:25101962).
messages: Expression is restricted to the nervous system.
messages: Perikaryon
messages: axon
messages: secretory vesicle lumen

6239:CELE C43H6.7
gene id: 6239:CELE_C43H6.7
uniprot id: Q18585
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE C50D2.2
gene id: 6239:CELE_C50D2.2
uniprot id: O44798
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C07A9.6
gene id: 6239:CELE_C07A9.6
uniprot id: P34317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C44E4.3
gene id: 6239:CELE_C44E4.3
uniprot id: O01804
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE C29E6.1
gene id: 6239:CELE_C29E6.1
uniprot id: Q27394
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Cleaved at the C-terminal domain.
messages: Expressed in external cuticle-producing epithelial cells including the epidermis, vulva, rectum, excretory duct and excretory pore.
messages: Lethal at the larval stage of development. Defects in the development of the excretory system during embryogenesis and the early stages of larval development. Dilated lumens of both the excretory canal cell and excretory duct which become apparent between the early and mid 3-fold stages of embryogenesis and increases in severity as development progresses. Lumen dialation may be as a result of fluid accumulation due to blockage of the lumen. At around the time of hatching, the autocellular junction, which usually seals the excretory pore tube, is absent. Detached excretory duct and pore cells, which usually connects the excretory canal cell to the outside environment for excretion. Irregular morphology of the epidermis and vulva in larvae at the L1 stage of larval development.
messages: Required for epithelial tube development and shaping (PubMed:27482894, PubMed:33141826). Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell (PubMed:7476875, PubMed:27482894, PubMed:33141826). Also plays a role in cuticle development, alae formation and shaping of the vulval lumen (PubMed:27482894). Required for larval development (PubMed:7476875, PubMed:27482894, PubMed:33141826).
messages: Secreted
messages: Secreted in the region between the embryo and inner layer of the eggshell. Expressed in excretory canal cells of embryos and at the 1.5-fold stage of embryonic development accumulates in the lumen of the excretory duct and pore. Expression ceases in the lumen of the excretory duct and pore prior to cuticle secretion. Thereafter expressed transiently in the lumen of the excretory duct and pore in the latter phase of each subsequent larval developmental stage. During the molt phase of larval development, accumulates in the space in between the new and old cuticles. During the L4 stage of larval development, accumulates in the vulval lumen.
messages: The ZP domain is required for localization at the apical cell membrane, secretion and excretory tube and vulval lumen expansion.
messages: extracellular space

6239:CELE T07C4.1
gene id: 6239:CELE_T07C4.1
uniprot id: G5EDZ2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 56 percent of embryos fail to hatch and are arrested at various stages between the bean stage and the four-fold stage (PubMed:20148972). 30 percent of L1 larvae fail to reach adulthood (PubMed:20148972). Embryos from the bean stage through to hatching have abnormally enlarged gut granules which fail to acidify (PubMed:20148972). Their size and number decreases at the L1 larval stage (PubMed:20148972). Normal gut granules in L2 larvae and adults (PubMed:20148972). Lysosomes in intestinal cells are mislocalized. 7 percent of embryos lack attachment of the anterior pharynx to the buccal cavity (PubMed:20148972). Exposure to hypertonic conditions reduces the number of vacuoles in mutant larvae (PubMed:20148972). Resistance to 5-fluorouracil (5-FU)-mediated toxicity (PubMed:19645718, PubMed:24262006).
messages: Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis (PubMed:19645718). May also form UMP from uracil (PubMed:19645718). Regulates the size of gut granules during embryonic development (PubMed:20148972). Involved in resistance to DNA damaging agents including UV-C and X-ray radiation (PubMed:24262006).
messages: Cytoplasm
messages: Expressed in intestine and in neurons near the nerve ring and rectum.
messages: Expression starts at the early embryonic pretzel-stage in the intestine and in a few cells in the head and the tail, and continues throughout larval stages and adulthood.
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

6239:CELE R12E2.11
gene id: 6239:CELE_R12E2.11
uniprot id: O61790
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Expressed in body wall muscles, spermatheca and vulva muscles.
messages: Homodimer.
messages: Phosphoribosyltransferase which catalyzes the formation of UMP from uracil in vitro and thus may be involved in UMP biosynthesis via the salvage pathway. May also participate in the first step of UMP synthesis by catalyzing the formation of orotidine 5'-phosphate, a UMP precursor, from orotate.

6239:CELE F59A6.6
gene id: 6239:CELE_F59A6.6
uniprot id: Q86MG7
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

6239:CELE C25D7.6
gene id: 6239:CELE_C25D7.6
uniprot id: Q9XVR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

6239:CELE ZK892.1
gene id: 6239:CELE_ZK892.1
uniprot id: Q09581
names: Function
messages: Binds galactose.

6239:CELE Y80D3A.4
gene id: 6239:CELE_Y80D3A.4
uniprot id: Q9U1R0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0511.8
gene id: 6239:CELE_B0511.8
uniprot id: O61818
names: Subcellular Location Annotation
messages: Mitochondrion

6239:CELE C49C8.4
gene id: 6239:CELE_C49C8.4
uniprot id: Q27482
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE H42K12.1
gene id: 6239:CELE_H42K12.1
uniprot id: Q9Y1J3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
messages: Cytoplasm
messages: Expressed in late stage embryos and throughout life. At L1, expressed in neurons, intestinal cells and hypodermal cells. In adults, expressed in the somatic gonad.
messages: Interacts directly with sgk-1, akt-1 and akt-2.
messages: Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage (PubMed:10364160, PubMed:21980302). Phosphorylates and activates sgk-1, akt-1 and akt-2 (PubMed:15068796).
messages: The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.

6239:CELE F09F7.5
gene id: 6239:CELE_F09F7.5
uniprot id: Q19275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

6239:CELE C38C10.4
gene id: 6239:CELE_C38C10.4
uniprot id: Q03569
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122).
messages: Interacts with gpr-1; gpr-1 forms a complex with lin-5 and GDP-bound goa-1.
messages: Simultaneous RNAi-mediated knockdown of both gpr-1 and gpr-2 causes, in the 1-cell embryo, a decrease in nuclear and spindle movements during prophase, reduced asymmetric spindle elongation during anaphase and mispositioning of nuclei after cell division.
messages: cell cortex
messages: spindle

6239:CELE W09C5.8
gene id: 6239:CELE_W09C5.8
uniprot id: Q9U329
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

6239:CELE T02E1.7
gene id: 6239:CELE_T02E1.7
uniprot id: O45731
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

6239:CELE B0286.5
gene id: 6239:CELE_B0286.5
uniprot id: Q10924
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the somatic gonadal precursor cells, Z1 and Z4, of XO and XX L1 stage larvae (PubMed:14993191). Expression is sexually dimorphic later in larval L1 stage and appears to be gonad-specific (PubMed:14993191).
messages: Nucleus
messages: Probable transcription factor (PubMed:14993191, PubMed:20553900). Binds to the DNA sequence motif 5'-[TA]TGTT[TG]T[TG][ATG]TT-3' (PubMed:20553900). Regulates sexual dimorphism in the gonad, promoting male gonadal cell fates in chromosomally (XO) male animals, yet plays a role in gonadogenesis in both sexes; probably acts downstream of terminal regulator of sex determination tra-1, to control early gonadogenesis (PubMed:14993191). Positively modulates expression of homeobox protein egl-5, probably acting indirectly, during early gonadal development (PubMed:20553900).

6239:CELE F54C8.3
gene id: 6239:CELE_F54C8.3
uniprot id: P34441
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC4 family.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells (PubMed:10749938, PubMed:12498686, PubMed:11134076, PubMed:17237515). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Negatively regulates ify-1 protein levels during meiosis I (PubMed:12498686). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
messages: The APC/C is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.
messages: The C-terminus is specifically required for completion of oocyte meiotic divisions.

6239:CELE C10H11.4
gene id: 6239:CELE_C10H11.4
uniprot id: P91038
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58G6.5
gene id: 6239:CELE_F58G6.5
uniprot id: Q21006
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F32D1.2
gene id: 6239:CELE_F32D1.2
uniprot id: O16298
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

6239:CELE F41E6.13
gene id: 6239:CELE_F41E6.13
uniprot id: O16466
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P-granules in somatic cells (PubMed:12958363, PubMed:19167332, PubMed:21183797, PubMed:21802374, PubMed:22451698, PubMed:25124690, PubMed:28557996). In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:21802374, PubMed:22451698). Plays a role in mitophagy, which is the autophagic consumption of mitochondria, in response to dietary restriction (PubMed:30133321). Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098). Also plays a role in membrane-pore repair (PubMed:27875098). In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for the proliferation of germ stem cell progenitors in the gonad during the late phases of larval development (PubMed:28285998). By regulating the release of neurotransmitters and neuropeptides, involved in the control of lifespan in response to dietary restriction and daf-2 signaling (PubMed:28557996). Probably through its involvement in autophagy, required for dauer formation (PubMed:12958363).
messages: Cytoplasm
messages: Expressed in neurons and intestinal cells.
messages: RNAi-mediated knockdown results in defective clearance of engulfed apoptotic cells (PubMed:21183797). RNAi-mediated knockdown reduces autophagic degradation of membrane pore-forming toxin Cry5B (PubMed:27875098). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998). RNAi-mediated knockdown causes abnormalities in constitutive dauer formation in daf-2 e1370 mutant including a lack of autophagosome formation (PubMed:12958363).
messages: The L/FRRG motif is required for recruitment to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
messages: phagosome membrane

6239:CELE R119.5
gene id: 6239:CELE_R119.5
uniprot id: H1ZUX5
uniprot id: O61706
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

6239:CELE F26F12.1
gene id: 6239:CELE_F26F12.1
uniprot id: Q19813
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T19H12.11
gene id: 6239:CELE_T19H12.11
uniprot id: Q3S1L2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F26B1.2
gene id: 6239:CELE_F26B1.2
uniprot id: P91277
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in gut, muscle, neuronal and hypodermal tissues (PubMed:31584932). Highly expressed in the germline and oocytes (PubMed:31584932).
messages: Interacts with alg-1; the interaction is direct and may be strengthened through RNA-protein association.
messages: Nucleus
messages: RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development (PubMed:31584932). Promotes the lsy-6-mediated repression of cog-1 in uterine cells (PubMed:31584932). In embryos, may play a role in the DNA damage response (PubMed:15654100).
messages: Temperature sensitive with 35% embryonic lethality at 20 degrees Celsius and 80% at 25 degrees Celsius (PubMed:31584932). Of the surviving offspring, 30% are sterile at 20 degrees Celsius and 76% are sterile at 25 degrees Celsius (PubMed:31584932). The majority of non-sterile animals have a reduced brood size (PubMed:31584932). In addition, animals have gonadal formation defects and display a bursting vulva phenotype (PubMed:31584932). Reduced number of miRNAs including miR-58 in embryos and L4 larvae (PubMed:31584932). Defective neuronal cell fate switching, whereby fewer ASEL neurons adopt an ASER cell fate in an lsy-6 mutant background (PubMed:31584932). In young adults, increased number of seam cells and enhanced hypodermal development defects in the double miR-48 and miR-241 mutant (PubMed:31584932). The majority of mutants are embryonic lethal in a miR-35-42 mutant background (PubMed:31584932). Enhanced defects in hypodermal development and alae formation in a let-7 mutant background (PubMed:31584932). RNAi-mediated knockdown relieves the lys-6-mediated repression of cog-1 in uterine cells (PubMed:31584932). RNAi-mediated knockdown results in increased sensitivity to the DNA-damage agent methyl methanesulfonate in embryos, but does not disrupt the morphology of the nucleus (PubMed:15654100). RNAi-mediated knockdown enhances the bursting vulva phenotype in a let-7 mutant background (PubMed:31584932).
messages: Ubiquitously expressed throughout development (PubMed:31584932). Highly expressed in early embryos (PubMed:31584932).

6239:CELE F33A8.1
gene id: 6239:CELE_F33A8.1
uniprot id: Q17336
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CWC22 family.
messages: Expressed in germ cells, oocytes, and sperm cells.
messages: Expressed ubiquitously throughout development.
messages: Nucleus
messages: Nucleus speckle
messages: RNAi-mediated knockdown results in germline masculinization and the accumulation of unspliced mRNAs in the cytoplasm.
messages: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939). Plays a role in sex determination (PubMed:23149939). Required for early embryogenesis and tissue differentiation.

6239:CELE W07E6.2
gene id: 6239:CELE_W07E6.2
uniprot id: Q9TYV3
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE PAR2.4
gene id: 6239:CELE_PAR2.4
uniprot id: P45895
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Expressed in distal tip cells of the growing gonad arms from L3 to the young adult stage (at protein level).
messages: Expressed in seam cells, the vulval epithelium and in oocytes (at protein level).
messages: Golgi stack membrane
messages: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin (PubMed:15485872). Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development (PubMed:15485872, PubMed:16982046). May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells (PubMed:16982046). Glycosyltransferase activity is weak (PubMed:15485872).
messages: Interacts with sqv-5.
messages: Viable but sterile, with reversion of cytokinesis during early embryogenesis.

6239:CELE Y55F3AM.15
gene id: 6239:CELE_Y55F3AM.15
uniprot id: Q9N359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2 and csn-4. In the complex, it probably interacts directly with csn-1, csn-2, csn-3 and csn-6. Interacts with itself.
messages: Cytoplasm
messages: Nucleus

6239:CELE T23B12.5
gene id: 6239:CELE_T23B12.5
uniprot id: O17000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

6239:CELE Y48A6C.4
gene id: 6239:CELE_Y48A6C.4
uniprot id: Q9XWK5
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

6239:CELE F25H2.10
gene id: 6239:CELE_F25H2.10
uniprot id: Q93572
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: P0 forms a pentameric complex by interaction with dimers of P1 and P2.
messages: Phosphorylated.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

6239:CELE F36H1.6
gene id: 6239:CELE_F36H1.6
uniprot id: G5ECV9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

6239:CELE F19F10.12
gene id: 6239:CELE_F19F10.12
uniprot id: Q95ZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

6239:CELE AH6.1
gene id: 6239:CELE_AH6.1
uniprot id: Q09435
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Expressed predominantly in sensory neurons. Expressed asymmetrically in the right ASE (ASER) neuron and bilaterally in ASI and URX neurons. Expressed in PVT and bilaterally in AIY non-sensory neurons. Expressed in intestine.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron (PubMed:19523832).
messages: Membrane
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F33C8.3
gene id: 6239:CELE_F33C8.3
uniprot id: Q19983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE Y19D10A.12
gene id: 6239:CELE_Y19D10A.12
uniprot id: A0A0M7RFF6
uniprot id: Q9UAT3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K10C8.3
gene id: 6239:CELE_K10C8.3
uniprot id: G5ECX8
uniprot id: G5EDV6
names: Similarity
messages: Belongs to the IST1 family.

6239:CELE E02C12.5
gene id: 6239:CELE_E02C12.5
uniprot id: P28052
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde-1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways (PubMed:19489741). Involved in behavioral response to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons (PubMed:25303524). Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons (PubMed:14988722).

6239:CELE Y57A10A.20
gene id: 6239:CELE_Y57A10A.20
uniprot id: Q9NA80
names: Function
names: Similarity
messages: Belongs to the SIN1 family.
messages: May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).

6239:CELE F41C3.3
gene id: 6239:CELE_F41C3.3
uniprot id: Q20264
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE K11D12.5
gene id: 6239:CELE_K11D12.5
uniprot id: O44620
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

6239:CELE C07A9.11
gene id: 6239:CELE_C07A9.11
uniprot id: P34322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

6239:CELE T27F6.6
gene id: 6239:CELE_T27F6.6
uniprot id: O45870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neutral sphingomyelinase family.
messages: Membrane

6239:CELE Y53C12C.1
gene id: 6239:CELE_Y53C12C.1
uniprot id: O01996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

6239:CELE ZK381.8
gene id: 6239:CELE_ZK381.8
uniprot id: Q4TT98
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE T09B4.9
gene id: 6239:CELE_T09B4.9
uniprot id: O02161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tin-44, tim-16 and tim-14/dnj-21. The complex interacts with the tim-23 component of the TIM23 complex.

6239:CELE Y54E5A.7
gene id: 6239:CELE_Y54E5A.7
uniprot id: Q9XWK4
names: Similarity
messages: Belongs to the RANBP9/10 family.

6239:CELE B0273.4
gene id: 6239:CELE_B0273.4
uniprot id: Q26261
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Expressed in cell bodies and axons of the VNC motor neurons that extend axons to the dorsal midline and within the ventral nerve cord (PubMed:12435363). Expressed in gonadal distal tip cells (DTC) (PubMed:16251208).
messages: Failed distal tip cell migration along the dorsal-ventral axis of the body. RNAi-mediated knockdown in mom-5, ced-10, ced-12 or mig-2 mutant backgrounds suppresses the migratory defect of distal tip cells in the respective single mutants.
messages: Glycosylated via C-mannosylation by dpy-19 at Trp-305 and Trp-308.
messages: In contrast to other members of the family, it lacks a canonical signal sequence; the existence of the signal sequence is therefore unsure.
messages: Interacts (via cytoplasmic domain) with src-1 (via SH2 domain and SH3 domain) (PubMed:16024786). Interacts with madd-4 (PubMed:25122090). Interacts with unc-129; the interaction is direct (PubMed:19169249).
messages: Membrane raft
messages: Phosphorylated on different cytoplasmic tyrosine residues (PubMed:11533026, PubMed:12435363, PubMed:16024786). May be phosphorylated on tyrosine residues by src-1 (PubMed:16024786). Tyrosine phosphorylation is unc-6-dependent (PubMed:11533026).
messages: Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).
messages: neuron projection

6239:CELE F13B12.1
gene id: 6239:CELE_F13B12.1
uniprot id: Q19375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus

6239:CELE Y77E11A.2
gene id: 6239:CELE_Y77E11A.2
uniprot id: Q9N4A9
names: Similarity
messages: Belongs to the NAD kinase family.

6239:CELE F14F9.5
gene id: 6239:CELE_F14F9.5
uniprot id: Q9GUC9
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F57B9.7
gene id: 6239:CELE_F57B9.7
uniprot id: H2KZX2
uniprot id: Q8MQ17
names: Similarity
messages: Belongs to the LRRFIP family.

6239:CELE R05D11.5
gene id: 6239:CELE_R05D11.5
uniprot id: Q21737
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

6239:CELE W07B8.4
gene id: 6239:CELE_W07B8.4
uniprot id: A0A0K3AVX9
uniprot id: O16288
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C07H6.7
gene id: 6239:CELE_C07H6.7
uniprot id: P34684
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Expressed in Q neuroblasts during larval development with higher expression in migrating QR.ap neuroblast descendents than in QL.ap neuroblast descendents.
messages: Interacts with nhr-25.
messages: Lin-39 and mab-5 double mutants have reduced sex myoblast specification-specific expression of sem-2 in the developing mesoderm (PubMed:21307099). RNAi-mediated knockdown in L1-stage larvae significantly reduces the fraction of unfused P5.p-P7.p cells that express egl-18 and elt-6 (PubMed:12399309).
messages: Nucleus
messages: Transcription factor (PubMed:21307099, PubMed:23784779, PubMed:12399309). Binds to the consensus 5'-TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression; sem-2 in order to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage), and egl-18 and elt-6 to regulate vulval development (PubMed:21307099, PubMed:12399309, PubMed:23784779). May bind to the PBC/Hox motif as a heterodimer with homeobox protein ceh-20 (PubMed:12399309). Regulates vulval precursor cell (VPC) differentiation, in concert with orphan nuclear receptor nhr-25 (PubMed:15314147). Regulates the expression of mig-13, which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts (PubMed:23784779). This in turn controls the polarity of migration of Q neuroblasts and the subsequent mid-body region-specific development (PubMed:8101475, PubMed:23784779).

6239:CELE C51E3.7
gene id: 6239:CELE_C51E3.7
uniprot id: G5ECN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Expressed in head and tail ganglia (PubMed:7954663, PubMed:11717360, PubMed:12657671, PubMed:24671950). Expressed in neurons including mechanosensory and motor neurons, and interneurons (at protein level) (PubMed:11717360, PubMed:12657671). Expressed in the nerve ring, ventral nerve cord and intestine (PubMed:24671950).
messages: Interacts (via C-terminus) with F-box protein fsn-1 (via SPRY domain); the interaction results in egl-3 proteasomal degradation.
messages: Secreted
messages: Serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:12657671, PubMed:15180830, PubMed:16945111, PubMed:23665919, PubMed:24671950). Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:12657671, PubMed:16945111). Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit (PubMed:23658528). Regulates sensitivity to mechanosensory stimuli (PubMed:11717360). By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions (PubMed:12657671). Probably by processing flp neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271). Cleaves pro-insulin-like proteins ins-3, ins-4 and ins-6 into their mature active forms (PubMed:23665919, PubMed:24671950). Together with convertase kpc-1, cleaves pro-insulin-like protein ins-18 (PubMed:24671950). By controlling ins-4 and ins-6 processing and thus the activation of the daf-2/InsR pathway, negatively modulates synapse development and synaptic transmission at neuromuscular junctions (PubMed:23665919). Similarly, by controlling ins-4 and ins-6 processing, negatively regulates dauer formation under optimal environmental conditions (PubMed:24671950). Under adverse environmental conditions, may promote dauer formation by processing ins-18, a daf-2/InsR antagonist (PubMed:24671950). May cleave dense-core vesicle membrane protein ida-1 (PubMed:15180830). Involved in egg-laying, fat storage and locomotion (PubMed:11813735, PubMed:11717360, PubMed:17564681).
messages: Ubiquitinated.
messages: axon
messages: secretory vesicle lumen

6239:CELE B0495.8
gene id: 6239:CELE_B0495.8
uniprot id: G8JXY3
uniprot id: Q09217
names: Similarity
messages: Belongs to the Luc7 family.

6239:CELE Y39A3B.2
gene id: 6239:CELE_Y39A3B.2
uniprot id: Q9N517
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F35D2.5
gene id: 6239:CELE_F35D2.5
uniprot id: Q86NH1
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the nerve ring of embryos. In L1 larvae, expression is seen in the ventral processes of ventral cord motor neurons. In adults, expression is seen along the dorsal and ventral nerve cords, the HSNL motor neuron and more specifically localizes to the axonal processes.
messages: Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1.
messages: Synapse
messages: Worms exhibit an irregular shape and fail to show axonic polarization. Uncoordinated movement and retention of eggs, an egg-laying defect are apparent.

6239:CELE C54C6.6
gene id: 6239:CELE_C54C6.6
uniprot id: Q86D25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP20 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.
messages: Nucleus
messages: centriole
messages: cilium axoneme
messages: cilium basal body

6239:CELE Y57G11C.22
gene id: 6239:CELE_Y57G11C.22
uniprot id: O18246
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

6239:CELE T04C9.6
gene id: 6239:CELE_T04C9.6
uniprot id: H2KZV9
names: Subcellular Location Annotation
messages: adherens junction

6239:CELE F58B3.3
gene id: 6239:CELE_F58B3.3
uniprot id: Q20968
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE T02E9.1
gene id: 6239:CELE_T02E9.1
uniprot id: O18014
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE ZC504.5
gene id: 6239:CELE_ZC504.5
uniprot id: O18280
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Chemoreceptor involved in light-induced avoidance behavior (PubMed:25640076). Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076). Involved in circadian rhythms, probably by acting as a light sensor (PubMed:27849618). In contrast to lite-1, does not act as a photoreceptor (PubMed:27863243).
messages: Expressed in I2 pharyngeal neurons.
messages: Membrane

6239:CELE C34B2.8
gene id: 6239:CELE_C34B2.8
uniprot id: O44955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

6239:CELE Y42H9B.1
gene id: 6239:CELE_Y42H9B.1
uniprot id: Q9N3X9
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE C52E4.2
gene id: 6239:CELE_C52E4.2
uniprot id: D6R8W7
names: Similarity
messages: Belongs to the MIF family.

6239:CELE ZK1290.2
gene id: 6239:CELE_ZK1290.2
uniprot id: G5EED8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

6239:CELE Y73F8A.11
gene id: 6239:CELE_Y73F8A.11
uniprot id: Q9NA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C26D10.1
gene id: 6239:CELE_C26D10.1
uniprot id: Q18211
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Key component of the Ran GTPase system, which comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
messages: Loss of ran-3 causes low levels of chromosomes to misalign on the metaphase plate and segregate incorrectly in early embryonic cell divisions.
messages: Nucleus

6239:CELE F44E7.9
gene id: 6239:CELE_F44E7.9
uniprot id: O16254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R07H5.2
gene id: 6239:CELE_R07H5.2
uniprot id: A0A061AL65
uniprot id: G5ECS9
uniprot id: G5EFE6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE Y54E10BL.6
gene id: 6239:CELE_Y54E10BL.6
uniprot id: Q10664
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Activated by tyrosine and threonine phosphorylation catalyzed by MAP kinase kinase kinases.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation (PubMed:7729690). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Involved in fluid homeostasis (PubMed:11689700). Positively regulates lifespan upstream of mpk-1 (PubMed:20624915).
messages: Interacts with ksr-1.
messages: RNAi-mediated knockdown causes a defect in pachytene progression resulting in a proximal gonad devoid of nuclei. The phenotype is more severe in gck-1 km15 mutant background (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915).

6239:CELE F32B5.8
gene id: 6239:CELE_F32B5.8
uniprot id: G5EGP8
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Cytoplasmic granule
messages: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:14630920). Probably, required for the degradation of the old cuticle (PubMed:14630920).
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:14630920, PubMed:16857685). In larvae, only expressed in hypodermis and cuticle (at protein level) (PubMed:14630920, PubMed:16857685). Expressed in the ecdysed cuticle during molting (at protein level) (PubMed:16857685). Expression transiently increases during early embryonic stages and prior to the larval L2/L3, L3/L4 and L4/adult molts (PubMed:14630920, PubMed:16857685).
messages: Expressed in hypodermis, cuticle and pharynx (at protein level) (PubMed:14630920, PubMed:16857685). Expressed in germ cells, developing oocytes, sheath cells surrounding germ cells and oocytes, and in the eggshell (at protein level) (PubMed:16857685). Not expressed in sperm (PubMed:16857685).
messages: RNAi-mediated knockdown causes an arrest at the 50-cell embryonic stage. The few surviving animals are arrested at the larval L2 to L3 molt with their cuticle remaining attached to the mid-portion of the body. RNAi-mediated knockdown at various larval stages causes severe defects in molting.
messages: Secreted
messages: The disulfide bridge formed between Cys-38 in the propeptide and the active site residue Cys-95 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue.

6239:CELE F48B9.8
gene id: 6239:CELE_F48B9.8
uniprot id: Q20557
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06B4.11
gene id: 6239:CELE_K06B4.11
uniprot id: O17933
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F07A11.4
gene id: 6239:CELE_F07A11.4
uniprot id: I2HA92
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE Y75B8A.31
gene id: 6239:CELE_Y75B8A.31
uniprot id: Q9XW78
names: Similarity
messages: Belongs to the FAM172 family.

6239:CELE Y4C6A.2
gene id: 6239:CELE_Y4C6A.2
uniprot id: A0A0K3AS42
uniprot id: A0A0K3AUI1
uniprot id: A0A0K3AV56
uniprot id: A0A0K3AXG3
uniprot id: A1IMB8
uniprot id: Q8MXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

6239:CELE B0035.7
gene id: 6239:CELE_B0035.7
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F18F11.5
gene id: 6239:CELE_F18F11.5
uniprot id: Q86ME2
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although the residues involved in the catalytic activity are absent, suggesting that the kinase is inactive, some kinase activity has been detected.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
messages: Expressed in vulval and body wall muscles, hypodermis, seam cells and tissues next to pharynx and anus.
messages: Membrane
messages: Negatively regulates lifespan and health span probably by participating in nutrient sensing.
messages: RNAi-mediated knockdown causes an increase in lifespan of about 60 percent compared to wild type but only when done at an early larval stage. Lifespan increase is associated with a decrease in the accumulation of the age pigment lipofuscin, a delayed age-onset nuclear membrane disintegration in muscles and loss of mobility. In addition, causes an increase in lipid catabolism resulting in fewer fat droplets in intestinal cells and hypodermis and lower triglycerides levels. Transcriptional up-regulation of genes involved in fatty acid degradation and in xenobiotic detoxification and decrease in cellular oxygen reactive species (ROS) production. Low brood size, longer reproductive span, increased autophagosome formation in seam cells and smaller body size. Normal pharyngeal pumping and feeding rate. RNAi-mediated knockdown in muscles or hypodermis causes a moderate increase in lifespan.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE ZC116.3
gene id: 6239:CELE_ZC116.3
uniprot id: Q20911
names: Function
names: Subcellular Location Annotation
messages: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake.
messages: Secreted

6239:CELE E04A4.6
gene id: 6239:CELE_E04A4.6
uniprot id: O44478
names: Similarity
messages: Belongs to the tectonic family.

6239:CELE Y37A1B.2
gene id: 6239:CELE_Y37A1B.2
uniprot id: A0A061AD14
uniprot id: N1NVC3
uniprot id: Q8I4E2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Aberrant vulval development, ectopic vulval induction, retained cell corpses and defective recruitment of dyn-1 and rab-7 to phagosomal surfaces.
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Expressed in vulval precursor cells (VPCs) and apoptotic germ cells. Colocalizes with actin, dyn-1 and rab-5 in early phagosomes.
messages: Highly expressed in all 6 vulval precursor cells (VPCs). At the time of inductive signaling, expression forms a gradient in response to inductive signal: expression is low in P6.p, intermediate in P5.p and P7.p and undiminished in P3.p, P4.p, and P8.p. Later, expression becomes strong again in P5.p and P7.p.
messages: Homodimer. Isoform d interacts (via SH3 domain) with dyn-1.
messages: Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate.
messages: The BAR and PX domains are required for recruitment to the phagosome.
messages: The SH3 domain is involved in phagosome maturation.
messages: phagosome membrane

6239:CELE F21G4.2
gene id: 6239:CELE_F21G4.2
uniprot id: G5EFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE Y18D10A.20
gene id: 6239:CELE_Y18D10A.20
uniprot id: Q9XW16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
messages: Expressed in the nerve ring during late embryonic stages. In adults, expression is seen in the neurons, vulva and somatic gonad.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

6239:CELE T26C5.3
gene id: 6239:CELE_T26C5.3
uniprot id: Q6BEU8
uniprot id: Q9XVX0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC101.2
gene id: 6239:CELE_ZC101.2
uniprot id: G1K109
uniprot id: H9G348
uniprot id: H9G349
uniprot id: H9G350
uniprot id: H9G351
uniprot id: H9G352
uniprot id: H9G353
uniprot id: H9G354
uniprot id: Q06561
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112.
messages: Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane (PubMed:8393416, PubMed:11438655, PubMed:17326220). May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells (PubMed:8393416, PubMed:17326220). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3 (PubMed:16495308). Involved in ovulation (PubMed:17326220). Required for normal lifespan (PubMed:36173858).
messages: Detected on embryonic and adult body wall muscle cells (at protein level) (PubMed:8393416, PubMed:10512861). Found in the basement membrane of all contractile tissues (at protein level) (PubMed:10512861). Expressed in gonadal sheath cells and spermatheca (PubMed:17326220).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: M line
messages: RNAi-mediated knockdown in L4 larval stage, causes a small increase in ectopic membrane extensions from body wall muscles (PubMed:16495308). RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 30 percent of animals (PubMed:17326220). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation, and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown reduces lifespan (PubMed:36173858).
messages: Synthesized early in embryogenesis.
messages: basement membrane

6239:CELE B0205.6
gene id: 6239:CELE_B0205.6
uniprot id: O61741
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

6239:CELE T02G5.13
gene id: 6239:CELE_T02G5.13
uniprot id: Q22111
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA and adenosylcobalamin metabolism.
messages: Mitochondrion
messages: Reduced incorporation of 1-[14C]-propionate. Defective in adenosylcobalamin synthesis. incorporation into macromolecules.

6239:CELE T21B10.2
gene id: 6239:CELE_T21B10.2
uniprot id: Q27527
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

6239:CELE C02F5.11
gene id: 6239:CELE_C02F5.11
uniprot id: Q95QY8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y50D4C.4
gene id: 6239:CELE_Y50D4C.4
uniprot id: A0A0K3AYD4
uniprot id: Q965Q8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Worms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell.

6239:CELE E01A2.7
gene id: 6239:CELE_E01A2.7
uniprot id: Q966L1
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

6239:CELE B0432.3
gene id: 6239:CELE_B0432.3
uniprot id: P90993
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE T07C4.6
gene id: 6239:CELE_T07C4.6
uniprot id: Q22289
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the E cell at the 8 cell stage and its daughter Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704).
messages: Nucleus
messages: RNAi-mediated knockdown causes about 5% embryonic lethality with 1-10% of hatching larvae displaying posterior morphological defects (PubMed:15892873, PubMed:15102704). Defective intercalation of dorsal hypodermis (PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-8 causes at least 48% of embryos to fail to hatch and those that do display severe morphological defects and die as larvae (PubMed:15892873, PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-8 abolishes muscle expression of vab-7 (PubMed:15102704). RNAi-mediated knockdown at the larval L1 stage causes a decrease in expression of lin-39 at the larval L3 stage (PubMed:24885717). Knockdown in L1 stage larvae, in a lin-39 mutant background, causes abnormal fusion of vulval precursor cells at larval stage L2 (PubMed:24885717).
messages: Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704). Involved in regulating expression of vab-7 (PubMed:15102704). Appears to have partially redundant function to tbx-8 (PubMed:15066124). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.

6239:CELE F37B12.2
gene id: 6239:CELE_F37B12.2
uniprot id: Q20117
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the glutamate--cysteine ligase type 3 family.
messages: By oxidative stress such as arsenite treatment.
messages: Expressed in intestine upon arsenite treatment.
messages: Plays a role in resistance to arsenite (PubMed:23593298). May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria (PubMed:22216003). Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting (PubMed:21199936).
messages: RNAi-mediated knockdown of gsr-1 in mutants lacking trxr-1 causes an arrest during larval molting characterized by a partial detachment of the old cuticle and an impaired ability to reduce cuticle components. Also results in growth arrest during the postdauer molt (PubMed:21199936). RNAi-mediated knockdown causes a severe loss of viability upon arsenite treatment (PubMed:23593298).

6239:CELE T22H6.1
gene id: 6239:CELE_T22H6.1
uniprot id: Q22687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-17 family.
messages: Expressed in RMG and AUA interneurons and ASE sensory neurons.
messages: Homodimer; disulfide-linked. Interacts with the receptor complex composed of ilcr-1 and ilcr-2 with the interaction being mediated by ilcr-2.
messages: Ligand for the receptor complex composed of ilcr-1 and ilcr-2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones.
messages: Secreted

6239:CELE C07D10.4
gene id: 6239:CELE_C07D10.4
uniprot id: P55113
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in the head of adult hermaphrodites but not within pharynx cells (PubMed:14653817). Expressed in pharyngeal muscles, mc cells, intestine, hypodermal seam cells, arcade cells, spermatheca, vulva and rectal epithelial cells (PubMed:20109220).
messages: In the embryo, expression is detected just before hatching.
messages: Metalloprotease.
messages: No visible phenotype. In a nas-6 (hd108) mutant background, enhances slow growth of nas-6 single mutant.
messages: Secreted

6239:CELE F09C6.9
gene id: 6239:CELE_F09C6.9
uniprot id: G5EE21
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F13D12.2
gene id: 6239:CELE_F13D12.2
uniprot id: Q27888
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE ZK512.1
gene id: 6239:CELE_ZK512.1
uniprot id: P34639
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C02C2.1
gene id: 6239:CELE_C02C2.1
uniprot id: P34269
names: Cofactor
names: Similarity
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.

6239:CELE C53D6.2
gene id: 6239:CELE_C53D6.2
uniprot id: G5EBY8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Expressed first at late gastrulation stage in cells that include descendants of the AB and E lineages (PubMed:9685266). Expression detected in dorsal body wall muscle (BWM) at the 1.5-to 2-fold stage of embryogenesis; also in some of cells in the head, including one ventral muscle (PubMed:9685266, PubMed:27341757). Between 520 min and hatching, expressed in the DA and DB motor neurons, excluding DA8 and DA9 (PubMed:9685266). This pattern of expression persists into adulthood (PubMed:9685266).
messages: Interacts with netrin receptor unc-5; the interaction is direct.
messages: Required for the migration of axonal growth-cones and distal tip cells (DTC) along the dorsal-ventral axis of the body wall (PubMed:9685266, PubMed:19169249, PubMed:9473333). Acts cell nonautonomously and independently of the classical daf-4, sma-6 or daf-1 TGFbeta receptor signaling (PubMed:9685266, PubMed:11018016, PubMed:19169249). During axon migration, facilitates long-range repulsive guidance of unc-6/netrin by enhancing unc-5-unc-40 signaling at the expense of unc-5 alone signaling, probably through direct interaction with receptor unc-5 (PubMed:19169249, PubMed:9473333). Involved in cell-cell contact formation in sensory rays in the developing male tail, via a pathway involving plx-2 and mab-20/semaphorin-2A (PubMed:15030761).
messages: extracellular space

6239:CELE W04B5.5
gene id: 6239:CELE_W04B5.5
uniprot id: Q9UA62
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE ZK616.8
gene id: 6239:CELE_ZK616.8
uniprot id: Q9N4M8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C29F5.7
gene id: 6239:CELE_C29F5.7
uniprot id: Q18311
names: Similarity
messages: Belongs to the globin family.

6239:CELE C53C9.2
gene id: 6239:CELE_C53C9.2
uniprot id: Q09936
names: Similarity
messages: Belongs to the calponin family.

6239:CELE C08E8.1
gene id: 6239:CELE_C08E8.1
uniprot id: O62039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE Y49A3A.3
gene id: 6239:CELE_Y49A3A.3
uniprot id: Q9XW93
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

6239:CELE Y47D3B.4
gene id: 6239:CELE_Y47D3B.4
uniprot id: Q9XX05
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F44E7.2
gene id: 6239:CELE_F44E7.2
uniprot id: O16247
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

6239:CELE W02D3.7
gene id: 6239:CELE_W02D3.7
uniprot id: O01814
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE Y59E9AL.7
gene id: 6239:CELE_Y59E9AL.7
uniprot id: G5EEU1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F16B4.11
gene id: 6239:CELE_F16B4.11
uniprot id: A0A0K3AXP8
uniprot id: O44637
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F12F6.9
gene id: 6239:CELE_F12F6.9
uniprot id: Q19368
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE M57.2
gene id: 6239:CELE_M57.2
uniprot id: Q9TYY0
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

6239:CELE ZC373.7
gene id: 6239:CELE_ZC373.7
uniprot id: Q23263
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y54G2A.18
gene id: 6239:CELE_Y54G2A.18
uniprot id: G5EBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

6239:CELE T23G5.6
gene id: 6239:CELE_T23G5.6
uniprot id: Q03615
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging (PubMed:21573134).
messages: Interacts with phosphorylated egl-4. May interact with itself. May be a component of a histone deacetylase complex containing saeg-2, saeg-1 and hda-2.
messages: Nucleus
messages: Ubiquitously expressed.

6239:CELE C24G6.4
gene id: 6239:CELE_C24G6.4
uniprot id: Q17370
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F35D11.3
gene id: 6239:CELE_F35D11.3
uniprot id: Q20035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

6239:CELE Y46H3C.2
gene id: 6239:CELE_Y46H3C.2
uniprot id: A0A0K3ASH0
uniprot id: Q9N4V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T24H7.4
gene id: 6239:CELE_T24H7.4
uniprot id: Q22756
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1. Interacts with glo-2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE Y105C5A.23
gene id: 6239:CELE_Y105C5A.23
uniprot id: Q9U320
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the ASI and ASK chemosensory neurons and in the IL-2 interneurons, but weakly expressed in other head neurons in hermaphrodites.
messages: G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.
messages: Heterodimer; with daf-37.

6239:CELE C56A3.8
gene id: 6239:CELE_C56A3.8
uniprot id: H2L2D3
uniprot id: O45318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

6239:CELE F08G2.2
gene id: 6239:CELE_F08G2.2
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F14H3.2
gene id: 6239:CELE_F14H3.2
uniprot id: O45363
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE F01G12.5
gene id: 6239:CELE_F01G12.5
uniprot id: P17140
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: Alternatively spliced, in part by RNA-binding protein asd-2, to produce isoforms which are expressed at different developmental stages (PubMed:18230701). Isoform a: Predominantly expressed in embryos (PubMed:7691828, PubMed:18230701). Isoform b: Predominantly expressed in larvae and adults (PubMed:7691828, PubMed:18230701).
messages: Belongs to the type IV collagen family.
messages: Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells (PubMed:19104038). Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons (PubMed:25080592). Vital for embryonic development (PubMed:7691828, PubMed:8045258).
messages: Intron retention.
messages: Localizes to the basement membrane between distal tip cells and the germline. Localizes to the intestinal basement membrane.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
messages: Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

6239:CELE K04A8.5
gene id: 6239:CELE_K04A8.5
uniprot id: Q94252
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Expressed in all larval stages. Expression decreases in adults.
messages: Lysosomal lipase that regulates the metabolism of long-chain fatty acids, primarily in response to nutrient availability (PubMed:21906946, PubMed:23392608, PubMed:25554789, PubMed:30713071). The production of these lipid signaling mediators regulates various processes, including lipolysis, autophagy, mitochondrial beta-oxidation, which in turn control lifespan and adaptation to starvation (PubMed:21906946, PubMed:23392608, PubMed:25554789, PubMed:30713071). In response to fasting, promotes the production of omega-6 polyunsaturated fatty acids (PUFAs), which in turn activates autophagy resulting in lifespan extension (PubMed:23392608). Produces oleoylethanolamide (OEA), a ligand for the lysosomal lipid chaperone lbp-8 which translocates into the nucleus where it activates the transcription of genes promoting longevity and activation of mitochondrial beta oxidation (PubMed:25554789, PubMed:30713071).
messages: Lysosome lumen
messages: RNAi-mediated knockdown has no effect on global lipase activity (PubMed:21906946). In a glp-1 (e2141) mutant background which lacks a germline, reduces the increase in both lipase activity and autophagy (PubMed:21906946).
messages: Up-regulated in the intestine by fasting.

6239:CELE EEED8.8
gene id: 6239:CELE_EEED8.8
uniprot id: Q09297
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

6239:CELE F01G4.2
gene id: 6239:CELE_F01G4.2
uniprot id: Q19102
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE Y47G6A.10
gene id: 6239:CELE_Y47G6A.10
uniprot id: Q9N3T5
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (PubMed:22700657, PubMed:25274306, PubMed:25773600). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Binds 1 zinc ion per subunit.
messages: Despite its gene name, this protein is an ortholog of human AFG3L2 and yeast AFG3 and not of human SPG7 and yeast YTA12 (C.elegans ortholog is actually ppgn-1).
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown induces nuclear and mitochondrial transcription of mitochondrial protective genes including chaperone hsp-60 as part of the mitochondrial unfolded protein response (PubMed:25773600, PubMed:25274306, PubMed:22700657). RNAi-mediated knockdown causes nuclear accumulation of transcription factor atfs-1 in intestinal cells (PubMed:22700657). RNAi-mediated knockdown results in mitochondria in intestinal cells which are abnormally elongated (PubMed:25274306). RNAi-mediated knockdown reduces oxygen consumption (PubMed:25773600). RNAi-mediated knockdown also induces the transcription of innate immunity-related genes such as lys-2, abf-2, clec-65 and clec-4 which results in resistance to P.aeruginosa-mediated infection (PubMed:25274306). RNAi-mediated knockdown abolishes transcription up-regulation in an atfs-1 (tm4919) mutant background (PubMed:22700657, PubMed:25274306, PubMed:25773600).

6239:CELE F15B9.1
gene id: 6239:CELE_F15B9.1
uniprot id: Q19478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE D2007.2
gene id: 6239:CELE_D2007.2
uniprot id: A0A1C3NSI2
uniprot id: A0A1C3NSP3
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C39B5.6
gene id: 6239:CELE_C39B5.6
uniprot id: Q9N5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

6239:CELE K08E3.7
gene id: 6239:CELE_K08E3.7
uniprot id: V6CLF7
names: Subcellular Location Annotation
messages: cytosol

6239:CELE M195.3
gene id: 6239:CELE_M195.3
uniprot id: Q21565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Involved in the uptake of ammonia.
messages: Membrane

6239:CELE T26A5.3
gene id: 6239:CELE_T26A5.3
uniprot id: Q22800
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

6239:CELE C14A4.11
gene id: 6239:CELE_C14A4.11
uniprot id: Q17958
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are sterile and develop slowly. Excretory canals are approximately 45% shorter and are characterized by a discontinuous and wider lumen, the presence of cysts and an increased number of canalicular vesicles which are swollen. These defects start during the L3 larval stage and become more severe when reaching adulthood. In addition, cdc-42 expression levels and activity are reduced along the excretory canal length. Animals have also a reduced distribution of Golgi and ER components along the excretory canals.
messages: Apical cell membrane
messages: Belongs to the PDCD10 family.
messages: Cytoplasm
messages: Expressed in pharynx, intestine, germline, vulva and excretory canals.
messages: Interacts with gck-1.
messages: Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.

6239:CELE C46C2.1
gene id: 6239:CELE_C46C2.1
uniprot id: X5M5N0
names: Activity Regulation
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated in response to hyperosmotic stress: cell shrinkage promotes formation of a membraneless compartment that concentrates wnk-1 with its downstrem substrates.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
messages: Cytoplasm
messages: Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of a cytoplasmic membraneless compartment that concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK.
messages: Expressed in pharynx, nervous system, hypodermis, spermatheca, excretory cell and canal and body wall muscles.
messages: Interacts with gck-3 (via C-terminus).
messages: RNAi-mediated knockdown causes impaired survival and slower volume recovery upon hypertonic stress.
messages: Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:36318922). Wnk-1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates wnk-1 with its substrates (By similarity). Phosphorylates gck-3 (PubMed:18049475). Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3 (PubMed:23076791). Essential for larval development and the tubular formation of the excretory canals (PubMed:18049475).
messages: Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.

6239:CELE Y48B6A.13
gene id: 6239:CELE_Y48B6A.13
uniprot id: Q9U294
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

6239:CELE Y55F3AM.6
gene id: 6239:CELE_Y55F3AM.6
uniprot id: Q9N373
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a complex at least containing lep-2, lin-28 and the long non-coding RNA lep-5, which mediates the degradation of lin-28.
messages: Cytoplasm
messages: E3 ubiquitin ligase which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the larval to adult transition by binding to the long non-coding RNA lep-5 to target the heterochronic protein lin-28 for degradation by the proteasome (PubMed:26811380, PubMed:30956008). This association and degradation of lin-28 also controls the timing of the sexual differentiation of individual neurons in males including the AIM, AWA, ADF, ASJ and CEM neurons (PubMed:31264582). Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380). Plays a role in two aspects of male mating behavior: response to hermaphrodite contact and vulva location (PubMed:26811380, PubMed:31264582). May play a role in the detection of preferred food sources (PubMed:31264582).
messages: Expressed from embryogenesis to adulthood (PubMed:26811380). Expressed in head neurons in L3 and L4 larvae (PubMed:31264582).
messages: Expressed in seam, tail tip, and other hypodermal cells, head and tail neurons, the pharynx, intestine and the developing hermaphrodite somatic gonad (PubMed:26811380, PubMed:31264582). Not expressed in body wall muscle cells (PubMed:26811380).

6239:CELE Y66A7A.5
gene id: 6239:CELE_Y66A7A.5
uniprot id: Q7K6J1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T12A7.2
gene id: 6239:CELE_T12A7.2
uniprot id: A0FLR6
uniprot id: L8E6K9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F43D9.3
gene id: 6239:CELE_F43D9.3
uniprot id: A7LPF3
uniprot id: Q20364
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

6239:CELE Y59H11AL.1
gene id: 6239:CELE_Y59H11AL.1
uniprot id: Q59E83
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Eggs are retained in the body as normal during starvation but the number of eggs laid during the initial refeeding period is reduced and satiety-induced suppression of pharyngeal pumping is slower than wild-type (PubMed:28847365). Suppression of serotonin-induced body fat loss (PubMed:28128367).
messages: Expressed in many cells, mainly in the head region, with expression detected in the head muscles, I2 neurons, MC neurons, RIH neuron, AIA neurons, AUA neurons, ASK neurons, ASI neurons, a few B-type motorneurons in the posterior ventral nerve cord, pharyngeal muscles, body wall muscles, the intestine and a few classes of unidentified cells anterior to the nerve ring (PubMed:28847365). Expression in the MC neurons is important to mediate suppression of feeding while expression in the RIH neuron is important for the facilitation of egg-laying (PubMed:28847365). No expression detected in other tissues including hypodermis (PubMed:28128367).
messages: Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior (PubMed:28847365). Receptor for flp-7 which stimulates serotonin-induced fat loss (PubMed:28128367). Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss (PubMed:28128367). Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide (PubMed:16377032). Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide (PubMed:16377032). The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22 (PubMed:16377032).

6239:CELE Y38E10A.6
gene id: 6239:CELE_Y38E10A.6
uniprot id: Q7K714
uniprot id: Q9U2M6
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K10D6.1
gene id: 6239:CELE_K10D6.1
uniprot id: Q21420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C42D8.2
gene id: 6239:CELE_C42D8.2
uniprot id: P05690
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the intestine of adult hermaphrodites.
messages: High sequence similarity with other vitellogenin genes means that assigning functions to individual proteins is difficult; authors sometimes refer to VITs or vitellogenins.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). Together with other vitellogenins, may play a role in modulating life-span, acting via induction of autophagy and lysosomal lipolysis (PubMed:26671266).
messages: Secreted
messages: Simultaneous RNAi-mediated knockdown of vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life span, causes accumulation of neutral lipid and an increase in lgg-1 foci in the proximal intestine; however, does not affect fertility or pharyngeal pumping rates (PubMed:26671266). Expression of transcription factors pha-4 and daf-16 are increased (PubMed:26671266).

6239:CELE B0464.1
gene id: 6239:CELE_B0464.1
uniprot id: Q03577
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

6239:CELE C32E8.11
gene id: 6239:CELE_C32E8.11
uniprot id: P91133
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the UBR1 family.
messages: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development (PubMed:28602583). Negatively regulates glutamate metabolism through the aspartate aminotransferase got-1.2 (PubMed:29649217). Modulation of glutamate levels most likely controls locomotory behavior, in particular backwards locomotion or 'reversals' (PubMed:29649217).
messages: Expressed in pharyngeal muscles, body wall muscles and a subset of neurons throughout postembryonic development (PubMed:29649217). Prominently expressed in premotor interneurons, but not expressed in ventral cord motor neurons (PubMed:29649217). Weakly expressed in hypodermal seam cells (PubMed:29649217).
messages: Interacts with ubc-1 (Probable). Component of a complex containing at least ced-3, ubr-1 and possibly ate-1 (PubMed:28602583). Within complex interacts with ced-3 (via the p17 subunit); this interaction is required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 (PubMed:28602583).
messages: Membrane
messages: RNAi-mediated knockdown enhances the excessive seam cell proliferation phenotype of the ain-1 ku322 mutant.
messages: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

6239:CELE C44C3.3
gene id: 6239:CELE_C44C3.3
uniprot id: Q8IFY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F17A2.7
gene id: 6239:CELE_F17A2.7
uniprot id: Q19505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE ZK593.5
gene id: 6239:CELE_ZK593.5
uniprot id: E2JKY8
uniprot id: E2JKZ0
uniprot id: L8E938
uniprot id: L8EC32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: Cytoplasm
messages: cytoskeleton

6239:CELE K04F1.4
gene id: 6239:CELE_K04F1.4
uniprot id: Q9TXK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T22F3.7
gene id: 6239:CELE_T22F3.7
uniprot id: Q94304
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T25G3.4
gene id: 6239:CELE_T25G3.4
uniprot id: P90795
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-binding enhances the activity of the enzyme.
messages: Mitochondrion

6239:CELE Y62E10A.17
gene id: 6239:CELE_Y62E10A.17
uniprot id: G2HK15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer.
messages: Cytoplasm
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with enhancer elements to regulate transcription of selected genes (By similarity). Required for neuroblast and epidermal morphogenesis, perhaps acting in cooperation with transcription factor aptf-4 (PubMed:27176626).

6239:CELE F09G8.8
gene id: 6239:CELE_F09G8.8
uniprot id: P34393
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C54A12.2
gene id: 6239:CELE_C54A12.2
uniprot id: A0A131MBD2
uniprot id: A0A131MC86
uniprot id: A0A131MCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE C28F5.2
gene id: 6239:CELE_C28F5.2
uniprot id: Q09240
names: Developmental Stage
names: Similarity
messages: Belongs to the globin family.
messages: Expression relative to adult is increased in the L3 stage and more so in dauers.

6239:CELE F53B1.7
gene id: 6239:CELE_F53B1.7
uniprot id: Q20701
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE C02F5.8
gene id: 6239:CELE_C02F5.8
uniprot id: P34285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE C34F6.4
gene id: 6239:CELE_C34F6.4
uniprot id: O17645
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). Involved in cell adhesion and guidance by specifically modifying proteoglycans in the extracellular matrix and on the cell surface that are essential for axon migrations.
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Present in the hypodermis, muscle, distal tip cells (DTCs) and in neurons (at protein level).
messages: Worms are viable but display axonal and cellular guidance defects in specific neuron classes.

6239:CELE H02I12.7
gene id: 6239:CELE_H02I12.7
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T27A3.3
gene id: 6239:CELE_T27A3.3
uniprot id: P91499
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE Y39C12A.5
gene id: 6239:CELE_Y39C12A.5
uniprot id: Q9U2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C48C5.1
gene id: 6239:CELE_C48C5.1
uniprot id: Q18701
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE Y17G7B.17
gene id: 6239:CELE_Y17G7B.17
uniprot id: Q9XXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

6239:CELE Y18H1A.6
gene id: 6239:CELE_Y18H1A.6
uniprot id: G5EFV7
uniprot id: V6CIU3
uniprot id: V6CL86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

6239:CELE R155.1
gene id: 6239:CELE_R155.1
uniprot id: O01925
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Probable acyltransferase which may mediate the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Required for incorporation of arachidonic acid into PC, PE, and PS.
messages: The di-lysine motif may confer endoplasmic reticulum localization.

6239:CELE Y71F9AM.5
gene id: 6239:CELE_Y71F9AM.5
uniprot id: G8JYG1
uniprot id: Q9U757
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus
messages: Preferentially binds Ran-GTP.
messages: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).

6239:CELE F19B10.9
gene id: 6239:CELE_F19B10.9
uniprot id: O02073
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional regulator involved in developmental processes (PubMed:16139225, PubMed:23666922). Directly binds to the promoter region of the sex-determining factor xol-1 to activate its transcription (PubMed:16139225, PubMed:23666922). Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development (PubMed:23666922). Has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153).

6239:CELE C56G2.6
gene id: 6239:CELE_C56G2.6
uniprot id: Q09517
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Expressed from first larval stage to adult.
messages: Expressed in the gut of larva and adult.
messages: Required for branched-chain fatty acid synthesis (such as (omega-1)-methyl-fatty acids) (PubMed:18390550). Catalyzes the reduction of the 3-keto-fatty acyl-CoA intermediate that is formed in each cycle of fatty acid elongation (PubMed:18390550). Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids (PubMed:12905072, PubMed:18390550, PubMed:21926990). Involved in hormone production as it metabolizes 4-androstendione (androst-4-ene-3,17-dione) into testosterone and estrone into estradiol (17beta-estradiol) in vitro, but the physiological steroid substrate is unknown (PubMed:17951538).
messages: Worms exhibit slow and retarded growth, reproductive and molting defects, defects in embryogenesis, and hypersensitivity to cholesterol limitation (PubMed:12905072). Increased polarity and tubulogenesis defects in an allelic series of let-767 (PubMed:21926990).

6239:CELE Y71G12B.15
gene id: 6239:CELE_Y71G12B.15
uniprot id: Q95XN7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6239:CELE Y51H4A.3
gene id: 6239:CELE_Y51H4A.3
uniprot id: Q22038
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cytoplasm
messages: GTP hydrolysis is stimulated by unc-89.
messages: Highest expression during larval development with a peak at L3 and lower levels in the embryo and adult (at protein level).
messages: In larvae and adults, enriched at the tip of the head where the anterior sensory organ is located and in the pharyngeal nerve ring (at protein level). In embryos, enriched at the boundaries of dorsal cells undergoing intercalation, ventral enclosure and elongation.
messages: May interact with unc-89 (via DN and PH domains) (PubMed:18801371). Interacts with bli-3 and memo-1 (PubMed:28085666).
messages: RNAi-mediated knockdown predominantly results in embryonic arrest with surviving embryos developing elongation-defective uncoordinated kinky larvae (PubMed:24016757, PubMed:11687661). Defective ventral migration of P cells leading to defective gonad development (PubMed:11687661). Defective establishment of anterior-posterior cell polarity in one-cell embryos (PubMed:16921365). Abolished cortical contractility in early embryos (PubMed:23064028). RNAi-mediated knockdown results in disorganized myosin thick filaments in the body wall muscles of the few surviving adults, which is characterized by the formation of abnormal myosin heavy chain myo-3 aggregates, V-shaped crossing of A-bands and areas in which the myosin heavy chain is missing (PubMed:18801371). RNAi-mediated knockdown suppresses reactive oxygen species induction and longevity in the memo-1 mutant (PubMed:28085666). Double RNAi-mediated knockdown with memo-1 eliminates the resistance to oxidative stress in the memo-1 single mutant (PubMed:28085666).
messages: Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation (PubMed:24016757). Also required for ventral migration of P cells during larval development (PubMed:11687661). Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development (PubMed:16921365). In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology (PubMed:21387015). In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89 (PubMed:18801371). Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity (PubMed:28085666).
messages: cell cortex
messages: cytoskeleton

6239:CELE F46F2.2
gene id: 6239:CELE_F46F2.2
uniprot id: Q20471
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Constant expression throughout development (PubMed:15691769, PubMed:29880558). However, expression decreases prior to the L2 larval stage, increases at the beginning of the L3 larval stage, and then decreases and plateaus from the mid L3 larval stage onwards (PubMed:31910362, PubMed:29880558). In the nervous system, expressed as dim speckles in developing DD motor neurons from the 3-fold stage of embryogenesis, then expression is dim in neurons of L1 stage larvae (PubMed:31910362). At the L2 larval stage, it is highly expressed in epidermal cells and motor neurons (PubMed:31910362). At the L4 laravl stage, it is expressed in all cell types and in the spermatheca (PubMed:31910362).
messages: Cytoplasm
messages: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms (By similarity). Casein kinases are operationally defined by their preferential utilization of acidic proteins (By similarity). Positively regulates the expression of components of the heterochronic pathway, which regulate developmental timing, such as the transcriptional repressor lin-42 and microRNAs such as let-7 (PubMed:29880558). Negatively regulates cell cycle exit and cell fusion to prevent the premature differentiation of hypodermal seam cells into adult cells (PubMed:15691769). Plays a role in regulating axon branching and subsequently, the maturation of the nervous system, most likely by preventing the premature termination of transcripts for proteins such as Ankyrin/unc-44, which are required for maintaining the nervous system (PubMed:31910362). May phosphorylate ssup-72 to promote nervous system maturation (Probable).
messages: Exhibits substrate-dependent heparin activation.
messages: Expressed throughout development.
messages: Expressed throughout larval development and into the adult stage in both hypodermal seam cells and the hermaphrodite specific neuron.
messages: Highly expressed throughout development.
messages: Monomer.
messages: Nucleus
messages: RNAi-mediated knockdown results in precocious seam cell fusion and the early exit of seam cell from the cell cycle during the L4 larval stage (PubMed:15691769). RNAi-mediated knockdown does not impair alae formation (PubMed:15691769). RNAi-mediated knockdown results in a squat body statue, referred to as a dumpy phenotype, and rescues the incomplete alae formation defect in the lin-42 (n1089) mutant (PubMed:29880558). RNAi-mediated knockdown increases the survival rate and partially restores alae formation of let-7 n2853 mutants at 20 dgrees Celsius (PubMed:15691769). RNAi-mediated knockdown rescues the lethal bursting phenotype that occurs after the L4 stage molt in the let-7(n2853) mutant at 25 degrees Celsius (PubMed:29880558).
messages: Weakly expressed throughout development.
messages: adherens junction
messages: centromere

6239:CELE C17E7.7
gene id: 6239:CELE_C17E7.7
uniprot id: A0A168H3P3
uniprot id: O16390
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W05H7.3
gene id: 6239:CELE_W05H7.3
uniprot id: O02173
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: perinuclear region

6239:CELE B0280.5
gene id: 6239:CELE_B0280.5
uniprot id: P41996
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in the germline.
messages: Expressed throughout development but appears to be up-regulated in adults.
messages: Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
messages: Worms lacking cpg-2 and cpg-1 exhibit defects in cytokinesis during embryo development more specifically meiotic chromosome segregation, polar-body extrusion, osmotic barrier function and polarization. Embryos lacking cpg-2 and cpg-1 proteins have multiple nuclei lacking plasma membranes and may also have weak egg shells. Oocytes lacking cpg-2 and cpg-1 show cortical granules that are reduced in size.

6239:CELE K05C4.11
gene id: 6239:CELE_K05C4.11
uniprot id: Q9XUU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C33H5.6
gene id: 6239:CELE_C33H5.6
uniprot id: Q18404
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F31E9.2
gene id: 6239:CELE_F31E9.2
uniprot id: O45426
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54C4.1
gene id: 6239:CELE_F54C4.1
uniprot id: Q9TZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

6239:CELE Y48G1A.3
gene id: 6239:CELE_Y48G1A.3
uniprot id: Q9N3Q8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in many ciliated sensory neurons.
messages: Fails to localize guanylate cyclase gcy-12 to sensory cilia.
messages: May be involved in the trafficking and dendritic transport of signaling proteins, such as the receptor-type guanylate cyclases gcy-12 and daf-11, to the cilia. In ciliated sensory neurons, required for the calcium flux to the cytoplasm in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846).
messages: cilium

6239:CELE H26D21.1
gene id: 6239:CELE_H26D21.1
uniprot id: G5EFI9
names: Similarity
messages: Belongs to the HUS1 family.

6239:CELE W09D12.1
gene id: 6239:CELE_W09D12.1
uniprot id: Q23227
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

6239:CELE B0464.5
gene id: 6239:CELE_B0464.5
uniprot id: Q03563
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with rsp-3.
messages: Predominantly coexpressed with rsp-3 in adult hermaphrodite germlines.
messages: Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro.

6239:CELE M04C9.1
gene id: 6239:CELE_M04C9.1
uniprot id: A5JYY7
uniprot id: A5JYY8
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE T04A11.3
gene id: 6239:CELE_T04A11.3
uniprot id: O18016
names: Subcellular Location Annotation
messages: Cell membrane

6239:CELE F32H5.5
gene id: 6239:CELE_F32H5.5
uniprot id: P91994
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C36A4.1
gene id: 6239:CELE_C36A4.1
uniprot id: Q27477
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T04D1.3
gene id: 6239:CELE_T04D1.3
uniprot id: B1V8A0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface (By similarity). Essential for synaptic vesicle endocytosis (PubMed:21029864). Plays a role in unc-57 localization to synaptic vesicles (PubMed:21029864). Dimerization and membrane-bending activity are required neither for binding to synaptic vesicles nor for unbinding following synaptic vesicle exocytosis (PubMed:21029864).
messages: Belongs to the endophilin family.
messages: Expressed in neurons and posterior intestine.
messages: Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis (PubMed:14622579, PubMed:21029864). By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion (PubMed:21029864). In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels (PubMed:22157748). Plays a minor role in responses to mechanical stimuli (PubMed:17928447). Plays a minor role in unc-26/synaptojanin localization to synapses (PubMed:14622579).
messages: May form a homodimer (via the BAR domain).
messages: Membrane
messages: Synapse
messages: The SH3 domain is required for unc-26/synaptojanin localization to synapses but is dispensable for endocytosis and unc-57 targeting to synaptic vesicles.
messages: synaptic vesicle

6239:CELE T05G11.3
gene id: 6239:CELE_T05G11.3
uniprot id: Q9XXJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C34E10.10
gene id: 6239:CELE_C34E10.10
uniprot id: Q95QS4
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE F56C9.3
gene id: 6239:CELE_F56C9.3
uniprot id: Q20864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE Y51H7BR.7
gene id: 6239:CELE_Y51H7BR.7
uniprot id: A0A8D9N0B5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C47C12.3
gene id: 6239:CELE_C47C12.3
uniprot id: Q7JNM3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed in the P cell lineage in hermaphrodites during the larval L1 stage (at protein level) (PubMed:12091304, PubMed:19386265). Expressed weakly in all 12 P cells just before P-cell migration, as migration occurs and in both P cell daughters after division in the ventral cord (at protein level) (PubMed:12091304). After division, expression decreases drastically in the Pn.a cell lineage; it continues in the Pn.p cells, and subsequently decreases at different rates in different Pn.p cells (at protein level) (PubMed:12091304). Also expressed in the B and Y cells in the tail region during L1 (PubMed:12091304, PubMed:19386265). Expressed in the early embryo in all MS descendants and in several related anterior sublineages of ABa that arise at the 50-cell stage (PubMed:35660370). In later embryos, expression occurs in two anterior sublineages of MS, in several anterior ABp-derived sublineages, and in the Pn ventral epidermal blast cells (PubMed:35660370). Expressed in many dividing cells in the embryo; at the end of gastrulation, expressed in some neuroblasts on the ventral side (PubMed:19386265). Expressed in the embryo at epidermal closure, at similar levels, in the daughters of the ABpl/rpapaa neuroblast, the anterior SMDD/AIY neuroblast, and the posterior SIAD/SIBV neuroblast (PubMed:19386265, PubMed:26073017). Expression in the AIY/SMDD lineage is transient and is lost during larval and adult stages (PubMed:19386265).
messages: Interacts with TCF transcription factor pop-1; the interaction is direct and facilitates transcriptional activation; transcription may be repressed by beta-catenin/sys-1.
messages: Nucleus
messages: RNAi-mediated knockdown causes many hermaphrodite progeny to be vulval-less and so unable to lay eggs (PubMed:12091304). Few or none of the Pn.p cells remain unfused in hermaphrodites or males (PubMed:12091304). In some conditions, despite being present in their normal position at hatching, P cells fail to migrate into the ventral cord during the larval L1 stage (PubMed:12091304).
messages: Transcription factor (PubMed:26073017). Modulates expression of target genes by binding to regulatory elements (PubMed:26073017). Required for normal cell division timing and cell positioning in anterior lineages, acting in a cell-autonomous manner (PubMed:35660370). Required for development, fusion and fate of cells of the ventral epidermis, the Pn.p cells, during larval development; acts in concert with homeobox genes lin-39 and mab-5 (PubMed:12091304). Required for the specification of the AIY interneuron (PubMed:19386265). In complex with TCF transcription factor pop-1, positively modulates expression of LIM/homeobox protein ttx-3 in anterior daughter cells of the SMDD/AIY neuron lineage (PubMed:19386265, PubMed:26073017).

6239:CELE C56C10.13
gene id: 6239:CELE_C56C10.13
uniprot id: Q95QQ1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

6239:CELE C27D6.8
gene id: 6239:CELE_C27D6.8
uniprot id: Q95ZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the head.
messages: G-protein coupled receptor.
messages: Perikaryon
messages: dendrite

6239:CELE T16G12.7
gene id: 6239:CELE_T16G12.7
uniprot id: K8FE09
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE ZK795.1
gene id: 6239:CELE_ZK795.1
uniprot id: O62519
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

6239:CELE T18H9.2
gene id: 6239:CELE_T18H9.2
uniprot id: Q86NE0
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C37E2.1
gene id: 6239:CELE_C37E2.1
uniprot id: Q93353
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
messages: Mitochondrion

6239:CELE Y37H2C.2
gene id: 6239:CELE_Y37H2C.2
uniprot id: Q9U2N1
names: Similarity
messages: Belongs to the SKP1 family.

6239:CELE C17A2.3
gene id: 6239:CELE_C17A2.3
uniprot id: O16535
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y75B8A.11
gene id: 6239:CELE_Y75B8A.11
uniprot id: Q9XW71
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor and controls food-related processes including feeding, lifespan, egg-laying and roaming behavior. Secreted in the presence of food, leading to reduced feeding and roaming behavior and increased egg laying and lifespan. Activity may be latent under normal conditions but induced under conditions that cause hyperactivation of the pharynx such as abrupt refeeding after starvation.
messages: Eggs are retained in the body as normal during starvation but the number of eggs laid during the initial refeeding period is reduced and satiety-induced suppression of pharyngeal pumping is slower than wild-type.
messages: Expressed in the M1 and M2 pharyngeal neurons from where the LURY-1-1 and LURY-1-2 peptides are secreted.
messages: In the M1 pharyngeal neuron, expressed in all larval stages and in adults. In the M2 pharyngeal neuron, expression is not detected in most L1-L3 larva but increases at the L4 larval stage.
messages: Secreted

6239:CELE C47E8.7
gene id: 6239:CELE_C47E8.7
uniprot id: Q18685
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the kindlin family.
messages: Cell membrane
messages: Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Probable regulator of cell-extracellular matrix adhesion (PubMed:10893272). Required during initial muscle assembly to form dense bodies and M-lines (PubMed:10893272).
messages: Interacts with pat-4/ILK (PubMed:12015115, PubMed:12781130). Probably forms a complex with pat-4 and pat-6 (PubMed:12781130). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: M line
messages: Mainly expressed in muscle cells in both embryos and adults.
messages: RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle. This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization.
messages: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

6239:CELE T10B10.7
gene id: 6239:CELE_T10B10.7
uniprot id: Q22374
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC581.7
gene id: 6239:CELE_ZC581.7
uniprot id: O01774
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE ZK675.2
gene id: 6239:CELE_ZK675.2
uniprot id: Q09615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

6239:CELE F21G4.1
gene id: 6239:CELE_F21G4.1
uniprot id: Q93550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane

6239:CELE Y39G10AR.13
gene id: 6239:CELE_Y39G10AR.13
uniprot id: G5EE37
uniprot id: X5M920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

6239:CELE Y19D10A.8
gene id: 6239:CELE_Y19D10A.8
uniprot id: A0A0M9JJ97
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y51A2D.11
gene id: 6239:CELE_Y51A2D.11
uniprot id: Q9XXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y39G10AR.3
gene id: 6239:CELE_Y39G10AR.3
uniprot id: A0A061AD48
uniprot id: A0A061AJL2
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

6239:CELE F12F6.3
gene id: 6239:CELE_F12F6.3
uniprot id: O01704
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Does not display any N-acetylglucosamine transferase II (GlcNAcT-II) and glucuronyl transferase II (GlcAT-II) activities when expressed alone in vitro.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Interacts with rib-2.
messages: RNAi-mediated knockdown results in the failure of hermaphrodite-specific neurons to migrate to their correct position associated with a defect in axonal guidance.
messages: Required for the biosynthesis of heparan sulfate by positively regulating N-acetylglucosamine transferase II (GlcNAcT-II) and glucuronyl transferase II (GlcAT-II) activities of glycosyltransferase rib-2 (PubMed:17237233). Probably not directly involved in chondroitin sulfate biosynthesis but negatively regulates chondroitin sulfate levels (PubMed:16828468, PubMed:17237233). Maternally required for normal ventral epidermal enclosure and for embryo elongation during the early stages of embryonic development (PubMed:17237233). In addition, involved in the elongation of the pharyngeal isthmus and in the organization of the actin cytoskeleton in the pharyngeal muscles during the later stages embryonic development (PubMed:16828468). In adults, regulates egg-laying and the normal morphogenesis of the vulva (PubMed:17237233). Also involved in the directed migration of hermaphrodite-specific neurons (PubMed:17237233, PubMed:24052309).

6239:CELE B0546.3
gene id: 6239:CELE_B0546.3
uniprot id: U4PBQ7
names: Similarity
messages: Belongs to the yippee family.

6239:CELE R186.3
gene id: 6239:CELE_R186.3
uniprot id: Q22013
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE C50B8.2
gene id: 6239:CELE_C50B8.2
uniprot id: G5ECJ5
names: Developmental Stage
names: Similarity
messages: Belongs to the IAP family.
messages: Expressed in embryos and in adult animals.

6239:CELE B0213.4
gene id: 6239:CELE_B0213.4
uniprot id: O44664
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora (PubMed:15048112, PubMed:19380113). May play a role in response to physical injury and osmotic stress (PubMed:18394898, PubMed:19380113). Through the neuropeptide receptor nlp-29, induces sleep upon activation of the innate immune response to molting and injury to the adult epidermis (PubMed:33259791).
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: In larva, expressed in an oscillating pattern with expression increasing during the lethargus phase, which occurs during molting between larval and adult stages.
messages: Secreted
messages: Upon D.coniospora and S.marcescens infection (PubMed:15048112, PubMed:19380113). Upon physical injury and osmotic stress (PubMed:19380113). Transcriptionally regulated by the transcription factor sta-2 upon activation of the innate immune response to molting and injury to the adult epidermis (PubMed:33259791).
messages: Weakly or not expressed in absence of infection. Upon infection by D.coniospora, it is expressed in hypoderm. Also expressed in perivulval cells when D.coniospora spores adhere to this region (PubMed:11717458, PubMed:15048112, PubMed:18394898, PubMed:19380113). Expressed in hypodermis upon physical injury (PubMed:18394898).

6239:CELE F28F9.4
gene id: 6239:CELE_F28F9.4
uniprot id: Q94197
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K04F1.3
gene id: 6239:CELE_K04F1.3
uniprot id: A0A0K3AVP7
uniprot id: Q9TXK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C43E11.4
gene id: 6239:CELE_C43E11.4
uniprot id: G5EDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

6239:CELE ZK616.6
gene id: 6239:CELE_ZK616.6
uniprot id: Q9N4N3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F59E10.1
gene id: 6239:CELE_F59E10.1
uniprot id: Q21037
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
messages: Nucleus
messages: ORC is composed of six subunits.

6239:CELE C25E10.7
gene id: 6239:CELE_C25E10.7
uniprot id: Q18156
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F11G11.2
gene id: 6239:CELE_F11G11.2
uniprot id: P91253
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).

6239:CELE F43G9.10
gene id: 6239:CELE_F43G9.10
uniprot id: Q93712
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MFAP1 family.
messages: Detected in intestine, pharynx, vulval muscles and body wall muscles.
messages: Developmental arrest at larval stage L1 or L2. RNAi-mediated knockdown results in aberrant splicing of tos-1 mRNA with increased intron 1 retention and exon 3 skipping, leading to increased expression levels of tos-1 isoforms 1 and 2. However there is no obvious recognition of the cryptic 3' splice site in tos-1 intron 1.
messages: Involved in pre-mRNA splicing.
messages: May be a component of the spliceosome.
messages: Nucleus

6239:CELE C04C3.2
gene id: 6239:CELE_C04C3.2
uniprot id: O44452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y73F4A.2
gene id: 6239:CELE_Y73F4A.2
uniprot id: Q9XWC3
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F57F10.1
gene id: 6239:CELE_F57F10.1
uniprot id: G5EBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

6239:CELE C45G9.7
gene id: 6239:CELE_C45G9.7
uniprot id: Q09506
names: Function
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.

6239:CELE F30B5.1
gene id: 6239:CELE_F30B5.1
uniprot id: P17657
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape.

6239:CELE T05H4.5
gene id: 6239:CELE_T05H4.5
uniprot id: O16521
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

6239:CELE Y45G5AM.1
gene id: 6239:CELE_Y45G5AM.1
uniprot id: G5EEM0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in germ and intestinal cells and at low levels in the hypodermis.
messages: First expressed in the embryo and subsequently in larvae and adults.
messages: It has been reported that mutant phenotypes can be rescued by tryptophan dietary supplementation, but not by methionine (PubMed:23499532). However, a later report describes successful phenotype rescue by methionine supplementation; this may be due to methodological differences (PubMed:33016879).
messages: No obvious somatic morphological defects in adults (PubMed:23499532). However, shows diet-sensitive sterility arising from germ-cell proliferation defects (PubMed:23499532). Sterile when fed the standard bacterial strain, E.coli B (OP50) as food source, and fertile when maintained on E.coli K-12 strains or bacterial soil isolates (PubMed:23499532). Dietary supplementation of L-tryptophan, but not the D isomer, to E.coli B strains suppresses sterility; this effect requires live bacteria (PubMed:23499532). Sterility when fed E.coli B strain OP50 can be rescued by dietary supplementation of either vitamin B12, methionine or choline (PubMed:33016879). RNAi-mediated knockdown targeted to the intestine, but not the germline, restored almost normal fertility on an E.coli OP50 diet (PubMed:23499532). RNAi-mediated knockdown on a rrf-1 mutant background, in which knockdown occurs mainly in the germline but occurs only weakly in somatic tissues, allowed recovery of a majority (64%) of fertile animals (PubMed:23499532). RNAi-mediated knockdown on an nhr-10 mutant background suppresses expression of acdh-1 (PubMed:33016879).
messages: Nucleus
messages: Probable transcription factor which may have a role in detoxifying dietary metabolites arising from bacterial tryptophan metabolism (PubMed:23499532). Required for fertility and involved in proper postembryonic germline development, especially germline stem cell (GSC) proliferation (PubMed:23499532). Required for activation of the methionine/S-adenosylmethionine (Met/SAM) cycle in response to low levels of SAM (PubMed:33016879).

6239:CELE F20D6.4
gene id: 6239:CELE_F20D6.4
uniprot id: A9Z1L1
uniprot id: Q6QUQ5
uniprot id: Q6QUQ6
names: Similarity
messages: Belongs to the serpin family.

6239:CELE Y92H12BL.1
gene id: 6239:CELE_Y92H12BL.1
uniprot id: Q8MXQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Membrane

6239:CELE Y60A3A.9
gene id: 6239:CELE_Y60A3A.9
uniprot id: Q9U1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE M03E7.1
gene id: 6239:CELE_M03E7.1
uniprot id: Q21500
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C47G2.5
gene id: 6239:CELE_C47G2.5
uniprot id: B2D6K9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SAPS family.
messages: Cytoplasm
messages: Expressed in embryos.
messages: Forms a complex composed of catalytic subunit pph-6 and regulatory subunit saps-1; the interaction increases pph-6 and saps-1 protein stability (PubMed:20040490). Interacts with kinase air-1 (PubMed:27335426).
messages: RNAi-mediated knockdown causes severe reduction in cortical contractions and lack of pseudocleavage furrow formation in the 1-cell embryo (PubMed:20040490, PubMed:27335426). Positioning of the spindle is abnormal due to reduced pulling forces that prevent oscillatory movements of the posterior spindle pole during anaphase (PubMed:20040490, PubMed:27335426).
messages: Regulatory subunit of protein phosphatase 6 (PP6) (Probable). In complex with pph-6, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning (PubMed:20040490). Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5 (PubMed:20040490). Negatively regulates kinase air-1 localization at the cell cortex (PubMed:27335426).
messages: cell cortex
messages: cytoskeleton
messages: spindle pole

6239:CELE W02A11.4
gene id: 6239:CELE_W02A11.4
uniprot id: Q9NAN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer with aos-1.
messages: The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).

6239:CELE C06B3.8
gene id: 6239:CELE_C06B3.8
uniprot id: Q6DNF7
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: No response to varying levels of oxygen. Significantly reduced aggregation and bordering behaviors.
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE F36F2.6
gene id: 6239:CELE_F36F2.6
uniprot id: Q95QG8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1 (PubMed:17291483). Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage (PubMed:17291483). May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells (PubMed:23903194).
messages: Nucleus
messages: RNAi-mediated knockdown causes an arrest at the 100-cell embryonic stage (PubMed:17291483). In developing oocytes, results in an abnormal accumulation of 'Ser-5' phosphorylated ama-1 and a more diffused nuclear localization of phosphorylated ama-1 (PubMed:17291483). 'Ser-2' phosphorylated ama-1 is present in diakinetic oocyte but at low levels indicating that transcription is possibly blocked at the elongation stage (PubMed:17291483). Increased levels of 'Ser-2' phosphorylated ama-1 in embryonic and germline nuclei (PubMed:23903194). Simultaneous knockdown of components of the transcription pre-initiation complex including ama-1, rbp-2, cdk-7, rgr-1 or taf-4 abolishes phosphorylation of the ama-1 CTD domain repeats at 'Ser-5' in diakinetic oocytes (PubMed:17291483). A similar abnormal accumulation of 'Ser-5' phosphorylated ama-1 occurs in 1-cell and 2-cell embryos (PubMed:17291483).

6239:CELE K11C4.3
gene id: 6239:CELE_K11C4.3
uniprot id: E0AHA7
uniprot id: G5EG85
uniprot id: Q9U9J8
uniprot id: S6FN00
names: Similarity
messages: Belongs to the spectrin family.

6239:CELE F38A6.3
gene id: 6239:CELE_F38A6.3
uniprot id: G5EGD2
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 66% do not survive embryogenesis when cultured in hypoxic conditions of 1% oxygen. Able to survive anoxic conditions (PubMed:11427734, PubMed:12006646). Inefficient translocation of aha-1 to the nucleus (PubMed:11427734). Inability to acclimate to heat (PubMed:12686697). Partial resistance to paralysis and killing by enteropathogenic E.coli and P.aeruginosa (PubMed:16091039, PubMed:20865124). Extends lifespan in a temperature dependent manner but not when grown with a restricted diet (PubMed:19461873, PubMed:21093262). At lower temperatures impairs lifespan because of a vulval integrity defect (PubMed:21241450). Unable to survive in even relatively low concentrations of hydrogen sulfide (PubMed:19889840). Reduced body levels of Mn(2+) and iron (PubMed:22194696). In low iron conditions, only 20% of animals reach the L4 larval stage (PubMed:22194696). RNAi-mediated knockdown causes an increase in ftn-1 and ftn-2 mRNA levels in normal conditions and prevents the repression of smf-3, ftn-1 and to a lesser extent ftn-2 mRNA transcription in response to low iron levels (PubMed:22194696).
messages: A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).
messages: Binds to aha-1 (PubMed:11427734). Interacts (hydroxylated on Pro-621) with vhl-1; the interaction induces hif-1 degradation (PubMed:11595184).
messages: By heat acclimation, hypoxia and addition of 50 ppm hydrogen sulfide (PubMed:11427734, PubMed:12686697, PubMed:19889840). By low iron levels (PubMed:22194696).
messages: Expressed in all somatic cells.
messages: Hydroxylation on Pro-621 by egl-9 during normoxia conditions is required for vhl-1-mediated proteasomal degradation.
messages: Nucleus

6239:CELE K05C4.6
gene id: 6239:CELE_K05C4.6
uniprot id: O44326
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-catenin family.
messages: Component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:25850673). Interacts with hmr-1; the interaction is direct (PubMed:10952315, PubMed:25850673, PubMed:26412237). May interact with hmp-1 (PubMed:11560894). Interacts with frk-1 (PubMed:20805471).
messages: Epidermal cells.
messages: Present in all embryonic blastomeres at early stages of development (at protein level).
messages: Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (PubMed:26412237).
messages: Worms have strong elongation defects (PubMed:9531567). RNAi-mediated knockdown results in failure of cadherin protein hmr-1 to localize to adherens junctions, but results in its accumulation along the basolateral membrane of the cell (PubMed:26412237).
messages: adherens junction

6239:CELE F10C1.7
gene id: 6239:CELE_F10C1.7
uniprot id: M1Z854
uniprot id: Q19286
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
messages: Expression is restricted to a discrete circumferential subapical layer within the intestinal terminal web (known as the 'endotube'); this layer joins directly to the apical junction complexes that connect adjacent gut cells.
messages: Lima bean stage of embryogenesis into adulthood.

6239:CELE F54F2.2
gene id: 6239:CELE_F54F2.2
uniprot id: P34447
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in somatic cells throughout development (at protein level) (PubMed:23263989). Isoform a: Predominantly expressed in embryos and adults (at protein level) (PubMed:23263989). Isoform c: Abundant at larval stages (at protein level) (PubMed:23263989).
messages: Isoform a: Expressed at high levels in maturing oocytes, but at low levels in the rest of the germ line (at protein level) (PubMed:23263989). Isoform a: Not expressed in the pharynx, germ line and tail (PubMed:27039057). Isoform c: Not expressed in the germ line (at protein level) (PubMed:23263989). Isoform c: Uniformly expressed (PubMed:27039057).
messages: Multimer; in vitro (PubMed:23806335). Interacts (via C-terminus) with dot-1.1 to form a heterodimer known as the zfp-1-dot-1.1 complex or DotCom complex (PubMed:23806335).
messages: Nucleus
messages: RNAi-mediated knockdown results in developmental defects such as slow growth, protruding vulva, and a reduced brood size (PubMed:16710447). RNAi-mediated knockdown results in germ line defects, resulting in no embryos or impaired oogenesis (PubMed:23263989). RNAi-mediated knockdown suppresses the multivulval phenotype of the lin-15A-lin15B n765 mutant (PubMed:16507136, PubMed:16710447). RNAi-mediated knockdown shortens the lifespan of daf-2 e1370 mutants (PubMed:27039057).
messages: Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription (PubMed:23806335). Recognizes and binds histone H3 methylated at 'Lys-4' (H3K4me) at the promoters of target genes (PubMed:23263989). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes (PubMed:23806335). In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated gene expression (PubMed:21980302). Thus, most likely via this mechanism, in response to stress, it confers a protective role against neuronal necrosis (PubMed:25422944). Plays a role in Insulin/IGF-1-like signaling (IIS)- and diet restriction-mediated lifespan extension by controlling daf-16/FOXO and pha-4/FOXA recruitment to target promoters (PubMed:27039057). May negatively regulate the expression of genes required for vulval development (PubMed:16507136, PubMed:16710447). May play a role in axon guidance in D-type motor neurons (PubMed:24066155). May suppress sensitivity to RNAi (PubMed:16507136).
messages: Required for migration of HSN motor neurons during embryogenesis.
messages: The PHD-type zinc finger 1 most likely mediates nuclear localization.
messages: The ePHD2 domain folds as an integrated structural module comprizing the C2HC pre-PHD-type 2 zinc finger and the PHD-type 2 zinc finger. It mediates non-specific binding to dsDNA, but does not bind histones in contrast to many PHD-type zinc fingers.

6239:CELE T01E8.5
gene id: 6239:CELE_T01E8.5
uniprot id: G5EG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRDE2 family.
messages: Interacts with nrde-3.
messages: Nucleus
messages: Nucleus speckle
messages: Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs-mediated silencing in nuclei (PubMed:20543824). Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerases I and II during the elongation phase of transcription (PubMed:20543824, PubMed:34365510). Required for exogenous RNAi-induced H3K27 methylation (PubMed:26365259).
messages: nucleolus

6239:CELE Y116A8C.14
gene id: 6239:CELE_Y116A8C.14
uniprot id: A0A0K3AV34
uniprot id: Q9U2S3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F07C4.5
gene id: 6239:CELE_F07C4.5
uniprot id: P91209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE T09E11.6
gene id: 6239:CELE_T09E11.6
uniprot id: O02312
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F41C6.7
gene id: 6239:CELE_F41C6.7
uniprot id: Q20272
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE C16C10.6
gene id: 6239:CELE_C16C10.6
uniprot id: Q09252
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NSRP1 family.
messages: Cytoplasm
messages: Early larval arrest, continued gonad expansion and shortened lifespan. RNAi-mediated knockdown results in continuous distal tip cell migration past the midline during adulthood. In a rnf-5(tm794) mutant background, increased severity of the distal tip cell migration defects.
messages: Expressed in the intestine, nervous system and head neurons in both larvae and adults (PubMed:17850180). Expressed in the distal tip cell (PubMed:22285439).
messages: Nucleus
messages: Required for the cessation of distal tip cell migration at the end of larval morphogenesis.

6239:CELE K07C11.5
gene id: 6239:CELE_K07C11.5
uniprot id: Q21265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Secreted

6239:CELE T22C1.7
gene id: 6239:CELE_T22C1.7
uniprot id: Q22667
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y19D10A.5
gene id: 6239:CELE_Y19D10A.5
uniprot id: G5EDB5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F16H6.7
gene id: 6239:CELE_F16H6.7
uniprot id: Q9XV94
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE T26C11.5
gene id: 6239:CELE_T26C11.5
uniprot id: Q22810
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F22B5.3
gene id: 6239:CELE_F22B5.3
uniprot id: Q19707
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Only expressed in late embryos.
messages: Plays a role in alae formation in L1 larvae.
messages: RNAi-mediated knockdown results in shorter and fatter dauer phase animals (dumpy phenotype), which have no alae (PubMed:15936343). RNAi-mediated knockdown results in a folded pharynx and intestine in some animals (PubMed:15936343).

6239:CELE T05G11.7
gene id: 6239:CELE_T05G11.7
uniprot id: G5EBL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y71A12C.1
gene id: 6239:CELE_Y71A12C.1
uniprot id: Q9XXB5
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F16B4.12
gene id: 6239:CELE_F16B4.12
uniprot id: O44638
uniprot id: Q8MNW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y95B8A.1
gene id: 6239:CELE_Y95B8A.1
uniprot id: Q9N2V2
names: Cofactor
names: Function
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.

6239:CELE R07B7.16
gene id: 6239:CELE_R07B7.16
uniprot id: Q21806
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Transcription up-regulated in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216.
messages: Transcriptional regulator (By similarity). Plays a role in modulation of lifespan and immunity (PubMed:29748542).

6239:CELE M01A10.1
gene id: 6239:CELE_M01A10.1
uniprot id: P91393
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F13G3.11
gene id: 6239:CELE_F13G3.11
uniprot id: Q95QL2
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

6239:CELE T19C4.2
gene id: 6239:CELE_T19C4.2
uniprot id: Q22569
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F49C12.13
gene id: 6239:CELE_F49C12.13
uniprot id: Q20591
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: In the 1.5-fold embryo, expressed in gut cells but not in epidermal cells (at protein level) (PubMed:15866168). In the 3-fold embryo, expressed in dorsal and ventral epidermal cells, but not in seam cells, and in the excretory cell (at protein level) (PubMed:15866168).
messages: RNAi-mediated knockdown causes hyperfusion of epidermal cells in embryos.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). During embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.

6239:CELE H02I12.4
gene id: 6239:CELE_H02I12.4
uniprot id: O45602
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE R07B7.10
gene id: 6239:CELE_R07B7.10
uniprot id: Q21800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE F16D3.7
gene id: 6239:CELE_F16D3.7
uniprot id: G5EBX8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F39B2.7
gene id: 6239:CELE_F39B2.7
uniprot id: Q9XTZ1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

6239:CELE ZK180.3
gene id: 6239:CELE_ZK180.3
uniprot id: Q23444
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

6239:CELE B0563.6
gene id: 6239:CELE_B0563.6
uniprot id: A8WFI5
uniprot id: Q11082
uniprot id: Q8MQF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE W03G1.1
gene id: 6239:CELE_W03G1.1
uniprot id: Q9UAY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE C03A7.3
gene id: 6239:CELE_C03A7.3
uniprot id: O16503
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y18D10A.8
gene id: 6239:CELE_Y18D10A.8
uniprot id: Q9XW13
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to ife-3 using a bipartite interface in the C-terminal domain which comprises a canonical helix which engages the ife-3 dorsal surface and a non-canonical helix which engages the ife-3 lateral surface.
messages: Cytoplasm
messages: Interacts with eukaryotic translation initiation factor ife-3.
messages: Plays a role in promoting translation.

6239:CELE F58E10.2
gene id: 6239:CELE_F58E10.2
uniprot id: G5EDN4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F39B2.2
gene id: 6239:CELE_F39B2.2
uniprot id: O45495
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Expressed from embryo to adulthood.
messages: Expressed in the pharynx, body wall muscle cells, vulval epithelia, distal tip cell, intestine, tail, head neurons and ventral cord motorneurons.
messages: Has no ubiquitin ligase activity on its own; may require ubiquitin-conjugating enzyme, ubc-13.
messages: Heterodimer with ubc-13.
messages: Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). Required for glr-1-containing glutamate receptor trafficking in neurons (PubMed:21179194). May have a role in synaptic transmission at motorneurons (PubMed:21179194). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772).
messages: Nucleus
messages: Perikaryon
messages: Temperature sensitive with partial embryonic lethality at 25 degrees Celsius (PubMed:24595290). Inhibited degradation of maternal membrane proteins, cav-1, chs-1 and rme-2, and ubiquitination of cav-1 with accumulation of these proteins on the maternal plasma membrane and endosome-like vesicles in later-stage embryos (PubMed:24595290). Locomotion defect with animals displaying increased body flexing (PubMed:21179194). Mis-localized glr-1-containing glutamate receptor with increased glr-1 accumulation in the ventral nerve cord (PubMed:21179194). Reduced and irregular snb-1 accumulation at neuromuscular junctions (PubMed:21179194). RNAi-mediated knockdown prevents localization of ubiquitin and proteasomes to polyglutamine protein aggregates (PubMed:17663792). Reduced size of polyglutamine protein aggregates (PubMed:17663792). Inhibited degradation of the maternal membrane protein, cav-1 in embryos (PubMed:24595290).
messages: cytosol
messages: dendrite

6239:CELE B0205.3
gene id: 6239:CELE_B0205.3
uniprot id: O61742
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the proteasome subunit S5A family.
messages: Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).
messages: Broadly expressed with high expression in the pharynx, intestine, hypodermis and spermatheca and weak expression in the excretory cell, body wall muscle, vulva and somatic gonad.
messages: Cytoplasm
messages: Nucleus
messages: Temperature-dependent increase in lifespan with a modest increase at 20 degrees Celsius and a 30% increase in mean lifespan at 25 degrees Celsius compared to wild-type animals (PubMed:26828939). Reduced fertility with no sperm produced in the spermatheca, accumulation of a sex-determination protein tra-2 in the intestine, no embryos in the uterus, and an increase in the development time to adulthood as evidenced by an expansion of the proximal oocytes at a young adult stage (PubMed:17050737, PubMed:26828939). Reduced ubiquitin-proteasome system function (UBS), particularly in dorsorectal neurons (PubMed:20453865, PubMed:26828939). Enhanced protein stability and increased resistance to protostasis in response to thermal stress and oxidative stress induced by tert-butyl hydroperoxide (PubMed:26828939). Irregular autophagy-lysosome pathway function with increased autophagy coupled with fewer intestinal lysosomes and reduced lysosomal function (PubMed:26828939). RNAi-mediated knockdown of skn-1 or elt-2 in the null mutant results in animals which are smaller and that developmentally arrest before adulthood (PubMed:26828939). RNAi-mediated knockdown results in reduced egg laying, abnormal gonad morphology with expansion of the proximal gonad greater than that of wild-type animals, and defective degradation of polyubiquitinated proteins and leads to an accumulation of these proteins (PubMed:17050737). Also results in delayed removal of paternal mitochondria until 4-fold stage of embryonic development (PubMed:22105480).
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.

6239:CELE F30F8.2
gene id: 6239:CELE_F30F8.2
uniprot id: Q93650
names: Similarity
messages: Belongs to the glutaminase family.

6239:CELE W04A4.3
gene id: 6239:CELE_W04A4.3
uniprot id: O45889
names: Similarity
messages: Belongs to the GILT family.

6239:CELE T10H4.12
gene id: 6239:CELE_T10H4.12
uniprot id: P43507
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C44C1.3
gene id: 6239:CELE_C44C1.3
uniprot id: P36608
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the recoverin family.
messages: Binds three calcium ions.
messages: Membrane
messages: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner.

6239:CELE T04A8.1
gene id: 6239:CELE_T04A8.1
uniprot id: P46568
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C04G2.1
gene id: 6239:CELE_C04G2.1
uniprot id: Q17629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE E01A2.6
gene id: 6239:CELE_E01A2.6
uniprot id: Q966L3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 16% embryonic lethality, reduced egg laying and a 0.9% increase in the number of male progeny (PubMed:23363597). Delayed progression of meiosis, which most likely results from defective disassembly of synaptonemal complex proteins, and defective chromosome structure, alignment and condensation (PubMed:23363597). RNAi-mediated knockdown results in reduced expression of the nlp-29 antimicrobial peptide following fungal infection by D.coniospora (PubMed:30036395). Worms show reduced body size and muscle function (PubMed:31767636). Worms lacking both akir-1 and ima-2 show reduced gonad size and aberrant diakinesis oocyte formation; defects are caused by impaired meiotic recombination (PubMed:30563860).
messages: Belongs to the akirin family.
messages: Expressed from the late embryo stage onwards, with high expression at the late L4 stage of larval development.
messages: Interacts with hda-1, a component of the NuRD complex (PubMed:30036395). Interacts with let-418, a component of the NuRD and MEC complexes (PubMed:30036395). Interacts with the transcription factor ceh-18 (PubMed:30036395). Interacts with ima-2 (PubMed:30563860).
messages: Localizes to somatic tissues throughout the body, including muscle cells (PubMed:31767636). Expressed in lateral epithelial seam cells, the hyp7 epidermal syncytium, and multiple head and tail neurons (PubMed:30036395).
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in antifungal innate immunity, development of the muscle and sister chromatid cohesion (PubMed:23363597, PubMed:30036395, PubMed:30563860, PubMed:31767636). Plays a role in antifungal innate immunity by acting as a bridge between components of the NuRD (Nucleosome Remodeling and Deacetylase) and MEC chromatin remodeling complexes (PubMed:30036395). NuRD and MEC complexes bind to the promoters of antimicrobial peptide genes and may recruit other proteins such as ceh-18 to control gene expression in response to fungal infection (PubMed:30036395). During meiotic prophase I, plays a role in the disassembly of synaptonemal complex proteins and in the regulation of chromosome condensation and segregation (PubMed:23363597). Together with nuclear import receptor ima-2, required for the import and load of cohesin complex proteins in meiotic nuclei, possibly by acting as a bridge between ima-2 and cohesins (PubMed:30563860). Required for embryonic development of muscle tissue (PubMed:31767636).
messages: Nucleus

6239:CELE T16G1.11
gene id: 6239:CELE_T16G1.11
uniprot id: Q9XUP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE R05D11.3
gene id: 6239:CELE_R05D11.3
uniprot id: Q21735
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).

6239:CELE Y37E11AR.7
gene id: 6239:CELE_Y37E11AR.7
uniprot id: Q86FM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

6239:CELE Y48G8AL.11
gene id: 6239:CELE_Y48G8AL.11
uniprot id: Q9BL17
uniprot id: V6CKC7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F55C5.5
gene id: 6239:CELE_F55C5.5
uniprot id: Q20819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

6239:CELE K09G1.4
gene id: 6239:CELE_K09G1.4
uniprot id: E7EM37
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in all dopaminergic neurons (PubMed:12887685). Expressed in neurons around the nerve ring and the posterior side of the body including PDE neurons (PubMed:12887685). In hermaphrodites, expressed in the head and tail ganglia including in the RIA interneuron pair, and in a subset of sublateral interneurons and the PDA neuron in the tail (PubMed:14568548). Expressed in cholinergic SIA neurons (PubMed:19609300). Also expressed in the male tail (PubMed:12887685, PubMed:23166505, PubMed:26156999). In males, expressed in the dorsal spicule protractor, ventral spicule protractor, dorsal spicule retractor and ventral spicule retractor muscles and the sensory post-cloacal sensilla B (PCB) neuron (PubMed:23166505). In males, expressed in the sensory hook neurons HOA (PubMed:26156999).
messages: Expressed in the head and tail ganglia of larval hermaphrodites.
messages: G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity leading to the activation of an associated G-protein and downstream signaling pathways (PubMed:12887685). Couples to G-proteins to inhibit adenylate cyclase (AC) activity and cAMP production (PubMed:12887685).
messages: G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity leading to the activation of an associated G-protein and downstream signaling pathways (PubMed:12887685). Couples to G-proteins to inhibit adenylate cyclase (AC) activity and cAMP production (PubMed:12887685). Inhibits synaptic vesicle fusion to negatively regulate the release of dopamine at dopaminergic neuron synapses (PubMed:31494966). Antagonizes octopamine signaling in response to food by promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons (PubMed:19609300). This is most likely in association with the G(o)-alpha G-protein subunit goa-1 (PubMed:19609300). In association with the G-alpha protein gpa-14, modulates two types of learning behavior: touch habituation and chemosensory associative conditioning (PubMed:23607404). May act partly via tsp-17 to negatively regulate dopamine reuptake transporter dat-1 activity (PubMed:25474638). Plays a role in behavioral plasticity and regulates the decision-making process when conflicting alternatives are present (PubMed:25536037). Promotes male mating behavior by antagonizing acetylcholine signaling to control the protrusions of copulatory spicules from the tail of males during hermaphrodite vulval location (PubMed:23166505, PubMed:26156999). Modulates unc-7 activity at gap junctions to promote inhibitory neuronal signaling transduction between chemosensory and mechanosensory neurons, and thus ensures spicule insertion attempts are confined to the hermaphrodite vulva during copulation (PubMed:26156999).
messages: Interacts (via C-terminus) with the G-alpha protein gpa-14; the interaction is direct.
messages: Modulates drug-mediated behavior, such as the response to nicotine and amphetamine (PubMed:20410438, PubMed:23351035). Plays a role in the sensitivity to the drug nicotine and promotes movement towards nicotine sources (PubMed:23351035). Plays a role in promoting amphetamine-induced loss of motility in water, termed swimming-induced paralysis (PubMed:20410438).

6239:CELE B0334.8
gene id: 6239:CELE_B0334.8
uniprot id: Q94125
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.
messages: Expressed both maternally and zygotically.
messages: Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause (PubMed:8700226, PubMed:21750263). Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3 (PubMed:25383666). Could function in the development or neuroendocrine signaling of the dauer pathway (PubMed:8700226). Mediates susceptibility to enteropathogenic E.coli infection (PubMed:16091039). May negatively regulate AYI interneuron neurite outgrowth (PubMed:22069193). Plays a role in aversive olfactory learning when an odor is associated with food deprivation (PubMed:27383131). Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning (PubMed:27383131).

6239:CELE B0024.12
gene id: 6239:CELE_B0024.12
uniprot id: Q17427
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

6239:CELE F01F1.13
gene id: 6239:CELE_F01F1.13
uniprot id: G1FC92
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Glycosylated via C-mannosylation by dpy-19 at Trp-58 and Trp-61.
messages: Membrane
messages: Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left-side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration.

6239:CELE W10G6.3
gene id: 6239:CELE_W10G6.3
uniprot id: O02365
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
messages: First expressed in embryos that are starting to elongate, before hemidesmosomes-associated filaments are recruited to regions of the hypodermis adjacent to muscle. Expressed throughout larval stages and in adults.
messages: Forms some heteromeric filaments with ifb-1.
messages: Mainly expressed in regions of the hypodermis adjacent to muscle. Expressed in longitudinal stripes where the mechanosensory neurons interface with the hypodermis. Also expressed to the uterine seam and within the uterine-vulval cells.
messages: hemidesmosome

6239:CELE F59H5.1
gene id: 6239:CELE_F59H5.1
uniprot id: Q9TZI4
names: Domain
names: Function
names: Subunit
names: Tissue Specificity
messages: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1.
messages: Expressed in some neurons including the head and tail neurons, HSN and VC, in a subset of glial cells, in the distal tips cells and in the intestine.
messages: Interacts (via GBA motif) with guanine nucleotide-binding protein G(o) subunit alpha goa-1 (in GDP-bound form); the interaction leads to activation of goa-1.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).

6239:CELE W04A8.7
gene id: 6239:CELE_W04A8.7
uniprot id: G5EGM3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF1 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed in embryo.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic arrest at the 100-cell stage, premature cell division of E2 cells, Ea and Ep, severe loss of polymerase II large subunit ama-1 phosphorylation and reduction in the transcription of several embryonic genes.
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-1 (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II (PubMed:14726532). Required for early embryonic development (PubMed:14726532). Essential for embryonic transcription of several genes (PubMed:14726532).

6239:CELE C09F5.1
gene id: 6239:CELE_C09F5.1
uniprot id: Q09231
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48G1C.10
gene id: 6239:CELE_Y48G1C.10
uniprot id: Q8IU06
uniprot id: V6CJW9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

6239:CELE M60.2
gene id: 6239:CELE_M60.2
uniprot id: Q9GYM9
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

6239:CELE C04F5.4
gene id: 6239:CELE_C04F5.4
uniprot id: Q9GZD4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C49D10.10
gene id: 6239:CELE_C49D10.10
uniprot id: O16607
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE C27C12.4
gene id: 6239:CELE_C27C12.4
uniprot id: Q18251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE LLC1.1
gene id: 6239:CELE_LLC1.1
uniprot id: Q22036
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase C2 family.
messages: Binds 3 Ca(2+) ions.
messages: Expressed in neuronal, but not in GABA-ergic neurons, intestinal, hypodermal and excretory tissues.
messages: RNAi-mediated knockdown prevents neuronal degeneration in a mec-4(u231), deg-1(u38) or gsa-1 gain-of-function mutant background.
messages: Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis (PubMed:10783162). Part of the necrosis cell death pathway (PubMed:12410314). Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa (PubMed:26795495).
messages: The C2 domain associated with the domain III is primarily responsible for calcium binding.
messages: The calpain catalytic domain is essential for in vivo function to promote female sexual development.

6239:CELE ZK945.2
gene id: 6239:CELE_ZK945.2
uniprot id: Q09583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE D1009.5
gene id: 6239:CELE_D1009.5
uniprot id: Q18917
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

6239:CELE F46C3.3
gene id: 6239:CELE_F46C3.3
uniprot id: B6VQ62
uniprot id: D3YT13
uniprot id: D3YT14
uniprot id: S6EZR2
uniprot id: S6FD20
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE T04F8.1
gene id: 6239:CELE_T04F8.1
uniprot id: Q22161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE F10C2.4
gene id: 6239:CELE_F10C2.4
uniprot id: P90829
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer with subunits of 125 kDa and 50 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity (By similarity).
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity).
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

6239:CELE R12C12.1
gene id: 6239:CELE_R12C12.1
uniprot id: Q21962
uniprot id: Q86LS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE M03C11.2
gene id: 6239:CELE_M03C11.2
uniprot id: Q21489
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus
messages: Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication.
messages: Uncoordinated and sterile with cell proliferation defects in germ and somatic cells. Hermaphrodite gonads have fewer cells with 13% of homozygotes having only one gonad arm. Most hermaphrodite mutants contain sperm but only 20% contain oocytes that develop as far as diakinesis and those that develop exhibit abnormal karyotypes. Mutant adults contain significantly fewer D neurons and seam cells than wild type. No poly-guanine tract deletions but double mutants of chl-1 and dog-1 display increased deletion frequency when compared to dog-1 mutants.

6239:CELE F17C8.9
gene id: 6239:CELE_F17C8.9
uniprot id: C0P278
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

6239:CELE K12H4.3
gene id: 6239:CELE_K12H4.3
uniprot id: P34524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

6239:CELE F37C12.11
gene id: 6239:CELE_F37C12.11
uniprot id: P49197
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

6239:CELE Y77E11A.1
gene id: 6239:CELE_Y77E11A.1
uniprot id: U4PBN7
uniprot id: U4PC09
names: Similarity
messages: Belongs to the hexokinase family.

6239:CELE F40E10.1
gene id: 6239:CELE_F40E10.1
uniprot id: Q21059
names: Cofactor
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in hypodermal cells. First expressed in the dorsal and lateral surface area of the middle and posterior region of embryos. At later stages, it localizes to lateral surface regions, probably corresponding to hypodermal seam cells. In L1 larvae, it is expressed in seam cells and in a few cells anterior to the nerve ring.
messages: In embryos, it is first expressed just before elongation.
messages: Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching (PubMed:8861940).
messages: Secreted

6239:CELE Y55B1AL.2
gene id: 6239:CELE_Y55B1AL.2
uniprot id: Q9N390
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxin-induced degradation of the protein causes no obvious phenotype in germ cells and early embryos.
messages: Belongs to the TFB5 family.
messages: Chromosome
messages: Component of the 7-subunit TFIIH core complex.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and in RNA transcription by RNA polymerase II (By similarity). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment (By similarity). In transcription, TFIIH has an essential role in transcription initiation (By similarity). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (By similarity). Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (PubMed:34824371). Required for efficient binding of TFIIH to damaged DNA (PubMed:34824371). Dispensable for normal development, but required when transcription is challenged (PubMed:34824371).
messages: Nucleus

6239:CELE ZC334.8
gene id: 6239:CELE_ZC334.8
uniprot id: Q7JKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F13G3.7
gene id: 6239:CELE_F13G3.7
uniprot id: Q19422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE H27D07.4
gene id: 6239:CELE_H27D07.4
uniprot id: O61910
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F56E10.1
gene id: 6239:CELE_F56E10.1
uniprot id: A0A0K3AS47
uniprot id: A0A0K3AUI7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F35H10.4
gene id: 6239:CELE_F35H10.4
uniprot id: G5EEK9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in embryos (at protein level) (PubMed:11441002). Expressed in the H-shaped excretory cell and pharynx in L2 larvae and adults (PubMed:11441002).
messages: Expressed in the H-shaped excretory cell (at protein level) (PubMed:11441002, PubMed:16785323, PubMed:17179093). Expressed in hypodermal cells around the vulva (PubMed:11441002). Expressed in the main epidermal syncytium (PubMed:16785323, PubMed:17179093). Expressed in the sheath cells associated with head and tail sensory organs; specifically, expressed in the apical sheath cells of the amphids and CEP neuron and in the sheath cells of the OLQ sensory organ (PubMed:17179093).
messages: RNAi-mediated knockdown causes larval lethality at the L2 stage (PubMed:11441002, PubMed:16785323). RNAi-mediated knockdown causes defects in alae formation in L1 larvae and in the few surviving adults (PubMed:16785323). Shorter body length (PubMed:16785323).
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in the assembly of the V-ATPase complex (PubMed:17179093). The V-ATPase is required for the function of the excretory canal (PubMed:16785323, PubMed:17179093). Independently of the V1 complex, the V0 complex of the V-ATPase is required for multivesicular body membrane fusion with the apical membrane of the epidermal cells during exosome release and thus regulates the release of cuticle components such as Hedgehog-related peptide wrt-2 but not collagen (PubMed:16785323). Also, in the epidermis, regulates the trafficking of che-14 and rdy-2 (PubMed:17179093). Regulates the secretion of granular material found in the amphid channel and in controlling osmoregulation in the amphid pocket (PubMed:17179093).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunit C vha-11 (PubMed:11441002).
messages: multivesicular body membrane

6239:CELE C12D8.1
gene id: 6239:CELE_C12D8.1
uniprot id: Q17935
uniprot id: Q17936
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T10E10.5
gene id: 6239:CELE_T10E10.5
uniprot id: Q86NE4
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C25G4.4
gene id: 6239:CELE_C25G4.4
uniprot id: Q18171
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Expressed in larval stage L3 male and hermaphrodite germlines, coinciding with sperm fate specification (at protein level) (PubMed:22570621). Expression persists throughout adulthood in males, but is absent in adult hermaphrodites that are undergoing oogenesis (at protein level) (PubMed:22570621).
messages: Nucleus
messages: Transcription factor which controls spermatogenesis and sperm cell fate by regulation of sperm gene expression.

6239:CELE ZK1037.13
gene id: 6239:CELE_ZK1037.13
uniprot id: A7LPI6
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F46B6.3
gene id: 6239:CELE_F46B6.3
uniprot id: Q20445
uniprot id: Q8WQF3
names: Similarity
messages: Belongs to the RENT3 family.

6239:CELE F11A6.2
gene id: 6239:CELE_F11A6.2
uniprot id: O62149
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE Y46G5A.24
gene id: 6239:CELE_Y46G5A.24
uniprot id: Q9U2E4
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

6239:CELE F19C7.4
gene id: 6239:CELE_F19C7.4
uniprot id: Q19590
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE C17D12.6
gene id: 6239:CELE_C17D12.6
uniprot id: Q9TVY6
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in spermatids, during spermogenesis expression is primarily localized to the pseudopod.
messages: Membrane
messages: Modifying each EGF repeat by changing a central cysteine residue to a tyrosine disrupts the secondary structure as the specific disulfide bridges responsible for this overall structure are not formed. The cysteine to tyrosine mutation when located in EGF-like domains 1,3,4 and 5, causes a complete loss of function. The same mutation in additional EGF-like domains leads to a temperature sensitive sterile phenotype.
messages: Removing the EGF-like repeats in any combination completely abolishes fertilization.
messages: Required for fertilization. May be required for cell adhesion and/or function as a signaling molecule.

6239:CELE Y73B6BL.29
gene id: 6239:CELE_Y73B6BL.29
uniprot id: Q95XD5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

6239:CELE K08D8.4
gene id: 6239:CELE_K08D8.4
uniprot id: Q21330
uniprot id: Q5CZ40
uniprot id: Q5CZ42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C03G6.15
gene id: 6239:CELE_C03G6.15
uniprot id: O02628
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T22D1.3
gene id: 6239:CELE_T22D1.3
uniprot id: Q9GZH3
uniprot id: V6CLC6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

6239:CELE C04F5.7
gene id: 6239:CELE_C04F5.7
uniprot id: Q9GZD1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y32G9A.4
gene id: 6239:CELE_Y32G9A.4
uniprot id: G5ECY2
names: Similarity
messages: Belongs to the serpin family.

6239:CELE F49F1.5
gene id: 6239:CELE_F49F1.5
uniprot id: Q9GZE4
uniprot id: U4PRI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y39G8B.10
gene id: 6239:CELE_Y39G8B.10
uniprot id: Q7YWR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C53A5.17
gene id: 6239:CELE_C53A5.17
uniprot id: A8WHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

6239:CELE T19C4.6
gene id: 6239:CELE_T19C4.6
uniprot id: P28051
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE C04H5.6
gene id: 6239:CELE_C04H5.6
uniprot id: O45244
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
messages: Embryonic lethal. Defects in oocytogenesis and spermatogenesis. Approximately 80% of mutants have an abnormal somatic gonad and no vulva.
messages: Expressed throughout development but most strongly in embryos and the L4 larvae stage.
messages: Interacts with mep-1 and smn-1.
messages: Nucleus

6239:CELE Y58A7A.1
gene id: 6239:CELE_Y58A7A.1
uniprot id: D6RYD3
uniprot id: Q966A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Late endosome membrane
messages: Membrane

6239:CELE ZK632.1
gene id: 6239:CELE_ZK632.1
uniprot id: P34647
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).
messages: Belongs to the MCM family.
messages: Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus

6239:CELE B0035.9
gene id: 6239:CELE_B0035.9
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE B0511.10
gene id: 6239:CELE_B0511.10
uniprot id: O61820
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE F13B9.1
gene id: 6239:CELE_F13B9.1
uniprot id: H2KZQ8
uniprot id: H2KZQ9
uniprot id: Q95ZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Golgi apparatus membrane

6239:CELE F13B9.5
gene id: 6239:CELE_F13B9.5
uniprot id: G5EFD2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Interacts with mek-2.
messages: Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration (PubMed:8521513, PubMed:11882296). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells (PubMed:8521513, PubMed:11882296). In addition, involved in determining vulval precursor cell fate during vulval induction independently of its kinase activity (PubMed:8521514, PubMed:8521513, PubMed:10409742, PubMed:11882296). Plays a role in egg-laying (PubMed:23900546).
messages: The kinase may be catalytically inactive.

6239:CELE F43E2.5
gene id: 6239:CELE_F43E2.5
uniprot id: O02089
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

6239:CELE F49C12.6
gene id: 6239:CELE_F49C12.6
uniprot id: Q20583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE C34F11.9
gene id: 6239:CELE_C34F11.9
uniprot id: H2KZ17
names: Similarity
messages: Belongs to the DSH family.

6239:CELE Y79H2A.11
gene id: 6239:CELE_Y79H2A.11
uniprot id: Q95QC4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Expressed in AFD thermosensory neurons.
messages: Interacts with tac-1.
messages: Maternal-effect embryonic lethal resulting in dramatic spindle positioning defects in one-cell stage embryos.
messages: Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase. Plays a role in regulating thermotaxis responses in AFD thermosensory neurons (PubMed:35675262).
messages: centrosome
messages: spindle

6239:CELE C54E4.3
gene id: 6239:CELE_C54E4.3
uniprot id: Q6DNF3
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE W02B3.4
gene id: 6239:CELE_W02B3.4
uniprot id: Q09341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Membrane

6239:CELE W07G1.2
gene id: 6239:CELE_W07G1.2
uniprot id: Q9XUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T03F1.2
gene id: 6239:CELE_T03F1.2
uniprot id: P91428
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Extends the life span.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE F26C11.2
gene id: 6239:CELE_F26C11.2
uniprot id: P29506
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Unc-4 subfamily.
messages: Interacts with unc-37.
messages: Most abundant during embryonic and larval development.
messages: Nucleus
messages: Specifically expressed in all A-type motor neurons (PubMed:7555714). The A-type motor neurons class includes 24 motor neurons; 9 DA, 3 SAB motor neurons that are generated in the embryo and 12 VAs arise after hatching in the first larval stage (PubMed:7555714).
messages: Transcription factor (PubMed:1347150, PubMed:7904971, PubMed:28056346). Involved in motor neuron fate determination and maintenance (PubMed:28056346, PubMed:34388088). In concert with unc-37, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate (PubMed:7904971, PubMed:9165118, PubMed:10557206, PubMed:11245684, PubMed:17289921). Regulates synaptic specificity and the pattern of synaptic input to VA motor neurons, and, depending on context, acting in opposition to, or supported by, Wnt signaling (PubMed:1347150, PubMed:7904971, PubMed:7555714, PubMed:22619391). Required in patterning of the synaptic outputs of the postmitotic DA class cholinergic motor neurons (PubMed:34388088). Acts as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons, probably by binding to specific promoter elements (PubMed:28056346). Has no role in axonal guidance or outgrowth (PubMed:1347150).
messages: Worms are unable to crawl backwards because VA motor neurons are miswired with synaptic connections normally reserved for their sister cells, the VB motor neurons.

6239:CELE Y65B4BL.2
gene id: 6239:CELE_Y65B4BL.2
uniprot id: Q9N303
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of P-granules which is required for P-granule formation and integrity in adult germ cells (PubMed:18234720). Promotes the accumulation of glh-1 mRNA and localization of pgl-1 to P-granules (PubMed:18234720). Involved in RNA-mediated gene silencing (RNAi) in the germline (PubMed:18234720, PubMed:32843637). In particular, it is required for piwi-interacting RNA (piRNA) gene silencing and positively regulates the formation of secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue (PubMed:32843637). Its role in RNAi may also be through positively regulating the expression of the dsRNA-binding protein rde-4 (PubMed:18234720). Plays a role in small RNA-directed transgenerational epigenetic inheritance (PubMed:27015309, PubMed:29769721).
messages: Cytoplasmic granule
messages: Expressed at all stages of development from embryogenesis to adulthood (PubMed:18234720). Expressed at all embryonic stages (PubMed:18234720).
messages: Expressed in germ cells.
messages: Interacts (via N-terminus) with prg-1; the interaction is direct (PubMed:32843637). May interact with edg-1 (PubMed:32843637).
messages: RNAi-mediated knockdown results in sterility and disrupts the localization of pgl-1 to P-granules at 24.5 degrees Celsius.
messages: perinuclear region

6239:CELE C50H11.1
gene id: 6239:CELE_C50H11.1
uniprot id: O16481
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y43C5B.2
gene id: 6239:CELE_Y43C5B.2
uniprot id: Q9XXE5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C32B5.7
gene id: 6239:CELE_C32B5.7
uniprot id: U4PME4
uniprot id: U4PRP9
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y54E2A.2
gene id: 6239:CELE_Y54E2A.2
uniprot id: Q9XWJ1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the SMG9 family.
messages: Defects in nonsense-mediated decay (NMD).
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.

6239:CELE T24H10.4
gene id: 6239:CELE_T24H10.4
uniprot id: Q22750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE ZK1058.5
gene id: 6239:CELE_ZK1058.5
uniprot id: Q23383
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

6239:CELE F42A8.2
gene id: 6239:CELE_F42A8.2
uniprot id: Q09545
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

6239:CELE F58A6.8
gene id: 6239:CELE_F58A6.8
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C18H9.5
gene id: 6239:CELE_C18H9.5
uniprot id: Q09484
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y71H10A.1
gene id: 6239:CELE_Y71H10A.1
uniprot id: Q9TZL8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE C44H9.1
gene id: 6239:CELE_C44H9.1
uniprot id: Q18629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE R04D3.6
gene id: 6239:CELE_R04D3.6
uniprot id: Q21714
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F58B3.5
gene id: 6239:CELE_F58B3.5
uniprot id: Q20970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

6239:CELE B0495.2
gene id: 6239:CELE_B0495.2
uniprot id: Q09437
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Broadly expressed in somatic and germ line cells (at protein level) (PubMed:29886128). Not expressed in sperm (at protein level) (PubMed:29886128).
messages: Nucleus
messages: Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L (PubMed:29886128). Important for normal oocyte and sperm development; probably required during multiple stages of gametogenesis (PubMed:29886128). Plays a role in the activation of RAS-ERK signaling in the germ line (PubMed:29886128). Also acts partially redundantly with cdk-11.2 to ensure embryonic viability (PubMed:29886128).
messages: Ubiquitously expressed during all stages of embryogenesis, but expression is low during the first few cell cycles (at protein level).
messages: Viable, but exhibit low fecundity and have a reduced brood size (PubMed:29886128). RNAi-mediated knockdown results in fertile adults that produce viable progeny (PubMed:29886128). RNAi-mediated knockdown in L1 stage cdk-11.2 bs101 mutants results in sterility (PubMed:29886128). RNAi-mediated knockdown in L4 stage cdk-11.2 bs101 mutants results in fertile adults that produce few viable embryos (PubMed:29886128).

6239:CELE Y111B2A.13
gene id: 6239:CELE_Y111B2A.13
uniprot id: Q9NEX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit.

6239:CELE Y69E1A.7
gene id: 6239:CELE_Y69E1A.7
uniprot id: A0A061ADS9
uniprot id: A0A131MBS2
uniprot id: Q9XW36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE ZK1320.5
gene id: 6239:CELE_ZK1320.5
uniprot id: Q09366
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K10C2.4
gene id: 6239:CELE_K10C2.4
uniprot id: Q94272
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the FAH family.
messages: Fumarylacetoacetase involved in the tyrosine degradation pathway.
messages: Highly expressed in the intestine and the hypodermis.
messages: RNAi-mediated knockdown from hatching results in stunted growth, reduced fertility, progressive destruction of the intestine by adulthood characterized by the thinning of the intestinal wall and loss of intracellular lipid droplets, which eventually culminates in lethality (PubMed:18227072). RNAi-mediated knockdown results in activation of cellular stress pathways, and thus the intestinal damage is most likely due to activation of oxidative stress responses and ER stress responses in the intestine (PubMed:18227072). The reduced fertility phenotype is enhanced in response to exogenous tyrosine or homogentisic acid (PubMed:18227072). RNAi-mediated knockdown together with tatn-1 RNAi, hpd-1 RNAi or hgo-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).

6239:CELE T11A5.2
gene id: 6239:CELE_T11A5.2
uniprot id: Q22382
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0348.1
gene id: 6239:CELE_B0348.1
uniprot id: O61959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE F57A8.5
gene id: 6239:CELE_F57A8.5
uniprot id: Q20916
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F35F11.1
gene id: 6239:CELE_F35F11.1
uniprot id: Q9N5U5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC73 family.
messages: Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.
messages: Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
messages: Nucleus
messages: RNAi mediated knock-down is embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells. 60% of embryos arrest at the bean stage of embryogenesis without any significant change in body shape. Nuclear localization of rtf-1 is unaffected.

6239:CELE Y94H6A.1
gene id: 6239:CELE_Y94H6A.1
uniprot id: Q9N2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T19A5.5
gene id: 6239:CELE_T19A5.5
uniprot id: A0A131MCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:KEF34 p11
gene id: 6239:KEF34_p11
uniprot id: P24886
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

6239:CELE Y51A2D.10
gene id: 6239:CELE_Y51A2D.10
uniprot id: F3Y5P3
uniprot id: Q9XXQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y40H7A.6
gene id: 6239:CELE_Y40H7A.6
uniprot id: Q9XW96
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R05D11.4
gene id: 6239:CELE_R05D11.4
uniprot id: Q21736
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

6239:CELE C30A5.3
gene id: 6239:CELE_C30A5.3
uniprot id: P34349
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOB1/phocein family.
messages: Golgi stack membrane
messages: May play a role in membrane trafficking, specifically in membrane budding reactions.
messages: Membrane
messages: perinuclear region

6239:CELE K03H1.1
gene id: 6239:CELE_K03H1.1
uniprot id: P34497
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Homooctamer.

6239:CELE K08H10.1
gene id: 6239:CELE_K08H10.1
uniprot id: G5EEF0
uniprot id: H2FLK8
uniprot id: H2FLL1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

6239:CELE Y40G12A.1
gene id: 6239:CELE_Y40G12A.1
uniprot id: Q965V9
names: Similarity
messages: Belongs to the peptidase C12 family.

6239:CELE C48D5.2
gene id: 6239:CELE_C48D5.2
uniprot id: P28191
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

6239:CELE T01D3.5
gene id: 6239:CELE_T01D3.5
uniprot id: Q9XVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane
messages: trans-Golgi network membrane

6239:CELE T10G3.4
gene id: 6239:CELE_T10G3.4
uniprot id: L8E717
uniprot id: P92166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE D1007.1
gene id: 6239:CELE_D1007.1
uniprot id: G5EC89
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ALA and SIA axons exhibit outgrowth abnormalities, failing to run along the lateral cord to the tail (PubMed:10887091). ALA axons are shortened further in a vab-8 mutant background (PubMed:10887091). Drastically reduced expression of let-23/EGFR and plc-3/PLCgamma in ALA neurons (PubMed:20501595). RNAi-mediated knockdown causes severe defects in the ALA neuron in young adults (PubMed:20501595).
messages: Belongs to the paired homeobox family.
messages: Expressed at the L1 larval stage in five neurons of the ring ganglia; a dorsal neuron, ALA, and four ventral SIA neurons (SIADR, SIADL, SIAVR and SIAVL) (at protein level) (PubMed:10887091). Earliest expression is at the end of gastrulation (PubMed:10887091). Expressed at the comma stage, in two dorsal neurons in the head, and in six cells on the ventral side of the head, just anterior to the excretory pore (PubMed:10887091).
messages: Nucleus
messages: Probable transcription factor involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA (PubMed:20501595). Regulates its own expression and also that of homeodomain ceh-14, together forming an autoregulatory loop in the ALA neuron (PubMed:20501595). Involved in fasciculation-independent longitudinal axonal navigation in many neurons (PubMed:10887091).

6239:CELE Y73E7A.4
gene id: 6239:CELE_Y73E7A.4
uniprot id: Q9GUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Positively regulates a late step in synaptic vesicle exocytosis.
messages: cytosol

6239:CELE T22E5.5
gene id: 6239:CELE_T22E5.5
uniprot id: Q27371
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.

6239:CELE F54F3.4
gene id: 6239:CELE_F54F3.4
uniprot id: G5EGA6
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10-phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione.

6239:CELE D2096.4
gene id: 6239:CELE_D2096.4
uniprot id: G5EF65
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

6239:CELE W09D10.4
gene id: 6239:CELE_W09D10.4
uniprot id: O18183
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE Y43F4A.1
gene id: 6239:CELE_Y43F4A.1
uniprot id: O62446
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Essential for the coordination of mitotic progression, and also plays a role in cell migration.

6239:CELE Y56A3A.4
gene id: 6239:CELE_Y56A3A.4
uniprot id: Q9U226
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF12 family.
messages: Interacts (via histone-fold domain) with taf-4 (via the histone-fold domain) (PubMed:18854162). Interaction may facilitate the nuclear localization of taf-4 (PubMed:18854162).
messages: Nucleus
messages: Part of the general transcription factor complex TFIID (By similarity). Plays a role in recruiting taf-4 to the nucleus and thereby activating transcription initiation by RNA polymerase II, as part of the TFIID complex (PubMed:18854162).
messages: RNAi-mediated knockdown reduces nuclear localization of taf-4.
messages: The histone-fold domain mediates hetero-dimer protein-protein interactions.

6239:CELE K09H11.1
gene id: 6239:CELE_K09H11.1
uniprot id: O01590
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE C15B12.1
gene id: 6239:CELE_C15B12.1
uniprot id: Q18006
names: Cofactor
names: Similarity
messages: Belongs to the MSOX/MTOX family.
messages: Binds 1 FAD per subunit.

6239:CELE ZK370.4
gene id: 6239:CELE_ZK370.4
uniprot id: Q02331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Membrane

6239:CELE C06B8.9
gene id: 6239:CELE_C06B8.9
uniprot id: Q86D23
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y87G2A.5
gene id: 6239:CELE_Y87G2A.5
uniprot id: Q9U1Q4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE B0222.9
gene id: 6239:CELE_B0222.9
uniprot id: Q960A1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1.
messages: RNAi-mediated knockdown reduces both the longevity-extending effects and generation of reactive oxygen species when exposed to 1 microM N1-methylnicotinamide.

6239:CELE Y41D4B.10
gene id: 6239:CELE_Y41D4B.10
uniprot id: Q95Y10
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE M142.1
gene id: 6239:CELE_M142.1
uniprot id: C0P283
uniprot id: G5EGP9
uniprot id: Q10658
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).
messages: Belongs to the PDE6D/unc-119 family.
messages: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.
messages: Predominantly neuron-specific.
messages: Worms exhibit diverse nervous system defects including defects in feeding behavior and chemosensation. Phenotypes are due to defects in protein trafficking, such as mislocalization of odr-3 and gpa-13 proteins in olfactory neurons.

6239:CELE F27E11.2
gene id: 6239:CELE_F27E11.2
uniprot id: A0A131MBV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

6239:CELE F54F2.1
gene id: 6239:CELE_F54F2.1
uniprot id: P34446
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin alpha chain family.
messages: Expressed in body-wall muscle cells, distal tip cells, and vulval tissue.
messages: Heterodimer of an alpha and a beta subunit (Probable). Interacts with beta subunit pat-3 (Probable). Interacts with dep-1 (PubMed:28135265). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: Membrane
messages: Required for muscle development probably through the regulation of the actin-myosin cytoskeleton (PubMed:8106547, PubMed:12915588). Component of an integrin containing attachment complex, which is required for muscle maintenance (PubMed:22253611). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52 (PubMed:16495308). Required for distal tip cell migration and dorsal pathfinding (PubMed:17606640). Required for egg-laying (PubMed:12915588). May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vulval development (PubMed:28135265). Probably within the alpha pat-2/beta pat-3 integrin receptor complex, plays a role in the negative regulation of let-23 signaling and vulval induction. This is probably partly by restricting the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).
messages: Severe paralysis at the 1-fold stage of embryonic development followed by an arrest in elongation at 2-fold stage (PubMed:8106547). Loss of myosin and actin organization in embryonic body wall muscles and loss of muscle cell polarization (PubMed:8106547). RNAi-mediated knockdown in post-hatching animals causes paralysis associated with severe disorganization of body wall muscle actin filaments and defects in egg-laying associated with embryonic hatching within the mother (the bag of worms phenotype) (PubMed:12915588). Few surviving adults, are uncoordinated with abnormal body size and shape and have defects in distal tip cells (DTC) migration resulting in abnormal gonad formation (PubMed:17606640). RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in vulval precursor cells in a let-60 gain of function mutant background results in increased vulval induction and an adjacent primary fate (Apf) phenotype whereby secondary vulval precursor cells transform into primary-like vulval cells (PubMed:28135265).
messages: Up-regulated during L3 developmental stage in distal tip cells.

6239:CELE F07A11.6
gene id: 6239:CELE_F07A11.6
uniprot id: G5EGK6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Isoform d interacts with daf-12.
messages: Isoform d is widely expressed: detected in the hypodermis, seam cells, intestine, somatic gonad, neurons, vulval precursors, body wall muscle and pharynx.
messages: Isoforms b and d are widely expressed from embryogenesis to adulthood. Isoform d is highly expressed in late L1 and L2 larval stages in XXX neuroendocrine cells. Isoform b is expressed more highly in the embryo and the L1 larval stage.
messages: Knockout of isoform d results in defective dauer formation. Eighteen percent of temperature sensitive mutants are embryonic lethal. The surviving animals are small (Sma), clear (Clr), uncoordinated, constipated and sterile. They display variable morphological defects in the main body and pharynx.
messages: Nucleus
messages: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause.

6239:CELE T01C3.9
gene id: 6239:CELE_T01C3.9
uniprot id: Q22058
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed throughout the male and female germline.
messages: Mortal germline (Mrt) phenotype in which there is a progressive decline in fertility with each generation at 25 degrees Celsius, and after 2 to 3 generations the brood size is 25% that of wild-type counterparts. Fertility in these mutants may be restored when transferred to a 20 degrees Celsius environment. Defective RNAi inheritance.
messages: Nucleus
messages: Plays a role in germline RNA interference (RNAi), and in particular is required for piwi-interacting RNA (piRNA) gene silencing. Facilitates the binding of the argonaut protein hrde-1 to small interfering RNAs (siRNAs) targets that are required for transgenerational epigenetic inheritance and germline immortality.

6239:CELE F29F11.4
gene id: 6239:CELE_F29F11.4
uniprot id: Q19907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C15H11.4
gene id: 6239:CELE_C15H11.4
uniprot id: Q9XVS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C08D8.2
gene id: 6239:CELE_C08D8.2
uniprot id: H2KYK4
uniprot id: Q8I7M7
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE F14F4.3
gene id: 6239:CELE_F14F4.3
uniprot id: G5EE72
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Expressed throughout development.
messages: Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments (PubMed:24836561, PubMed:28581477). Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development (PubMed:29562169).
messages: Highly expressed in the intestine and pharynx (PubMed:24836561, PubMed:29562169). Expressed at low levels in the hypodermis and in some neurons (PubMed:24836561).
messages: RNAi-mediated knockdown in larvae does not result in any obvious developmental defects and animals are able to reach the adult gravid stage and lay eggs (PubMed:24836561). However, 80% of the eggs laid fail to hatch, and the animals that hatch do not survive beyond the L1 larval stage (PubMed:24836561). RNAi-mediated knockdown in larvae results in the heme accumulation in the intestine under low heme conditions (PubMed:28581477). RNAi-mediated knockdown in larvae results in an accumulation of vitamin B12 in the intestine and defective vitamin B12 transport from mother to dead embryos (PubMed:29562169). Furthermore, embryos of RNAi-treated mothers also have defects in vitamin B12 metabolism and have reduced levels of methionine and S-adenosylmethionine (PubMed:29562169). Double RNAi-mediated knockdown with hrg-7 in larvae results in defective heme sensing (PubMed:28581477).

6239:CELE F56H1.5
gene id: 6239:CELE_F56H1.5
uniprot id: O76373
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia (PubMed:21982591, PubMed:29129530). In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles (PubMed:29129530). Also regulates microtubule dynamics in uterine muscle cells (PubMed:24780738).
messages: In hermaphrodites and males, expressed in amphid and IL2 ciliated sensory neurons (PubMed:20519502, PubMed:21982591). In males, expressed in CEM head neurons, RnB and HOB tail neurons, and in gubernacular erector and retractor muscles (PubMed:21982591).
messages: Perikaryon
messages: RNAi-mediated knockdown at the L1 or L4 larval stages causes a defect in egg-laying without affecting uterine and vulva muscle function.
messages: cilium
messages: dendrite

6239:CELE C24B9.15
gene id: 6239:CELE_C24B9.15
uniprot id: Q86B38
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C34C6.4
gene id: 6239:CELE_C34C6.4
uniprot id: Q18429
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

6239:CELE C37H5.1
gene id: 6239:CELE_C37H5.1
uniprot id: A0A131MB16
names: Similarity
messages: Belongs to the annexin family.

6239:CELE C02F5.9
gene id: 6239:CELE_C02F5.9
uniprot id: P34286
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

6239:CELE K02D7.4
gene id: 6239:CELE_K02D7.4
uniprot id: G5ECG7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the transport of cholesteryl ester, and phospholipid between phospholipid surfaces (By similarity). Does not catalyze transport of triglycerides (PubMed:17924655). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:17924655, PubMed:14657502). Required for normal expression of klf-3 (PubMed:23639358).
messages: Endoplasmic reticulum
messages: Expressed in the intestine throughout larval stages and adulthood.
messages: Heterodimer; heterodimerizes with protein disulfide isomerase.
messages: RNAi-mediated knockdown suppresses the slow germline development and the delayed egg-production of clk-1 mutants, but does not affect the rate of postembryonic development.

6239:CELE Y54E10A.11
gene id: 6239:CELE_Y54E10A.11
uniprot id: Q65XX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase ltn1 and nemf. The complex probably also contains tcf25 as well as vcp/p97 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.
messages: cytosol

6239:CELE R07B1.12
gene id: 6239:CELE_R07B1.12
uniprot id: G5EBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

6239:CELE VC5.6
gene id: 6239:CELE_VC5.6
uniprot id: Q2V068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C07G1.3
gene id: 6239:CELE_C07G1.3
uniprot id: Q8I7M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Binds 2 Mg(2+) ions.
messages: Cytoplasm
messages: Interacts with cyy-1; the interaction is required to activate pct-1.
messages: Serine/threonine-protein kinase, which, in association with cyy-1, regulates the trafficking of synaptic vesicles in the DA9 motor neuron and probably also in the DD motor neurons and in RIA interneurons.
messages: Sufficient for synaptic vesicle trafficking in the DA9 motor neuron.
messages: axon
messages: dendrite

6239:CELE Y54G9A.10
gene id: 6239:CELE_Y54G9A.10
uniprot id: Q5DTE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C15F1.3
gene id: 6239:CELE_C15F1.3
uniprot id: P34709
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: Interacts with tra-1 and fem-3.
messages: Isoform Tra-2B is likely to be cytoplasmic because it lacks an N-terminal sequence and potential membrane spanning domains.
messages: Membrane
messages: Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also required for feminizing tra-3 activity.
messages: Produced by alternative initiation at Met-1089 of isoform Tra-2A.
messages: Somatic and germline tissues. Isoform Tra-2B is specific to oocytes.
messages: The MX region mediates a post-translational regulation, essential for the onset of hermaphrodite spermatogenesis.
messages: Undergoes cleavage by tra-3 to produce a feminizing carboxy-terminal isoform Tra-2B.

6239:CELE T26E3.7
gene id: 6239:CELE_T26E3.7
uniprot id: O45827
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

6239:CELE Y41E3.2
gene id: 6239:CELE_Y41E3.2
uniprot id: O62432
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C49F5.4
gene id: 6239:CELE_C49F5.4
uniprot id: O17683
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K05B2.4
gene id: 6239:CELE_K05B2.4
uniprot id: Q9GYN3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE ZK1236.3
gene id: 6239:CELE_ZK1236.3
uniprot id: P34619
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.
messages: Binds through its N-terminal region to the N-terminal region of sop-2.
messages: Expressed at all developmental stages with levels declining as development proceeds.
messages: Nucleus
messages: Worms exhibit early larval lethality and anterior to posterior cell fate transformation in a Hox gene-dependent manner. Hermaphrodites show vulva defects, partial hermaphrodite-to-male sexual transformation and are sterile.

6239:CELE C53A3.2
gene id: 6239:CELE_C53A3.2
uniprot id: O44538
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

6239:CELE C24B9.11
gene id: 6239:CELE_C24B9.11
uniprot id: O76440
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W02B12.2
gene id: 6239:CELE_W02B12.2
uniprot id: Q23120
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood.
messages: RNA-mediated interference (RNAi) of rsp-1 and rsp-2 result in reduced brood sizes and abnormal egg-laying behavior, and the presence of unusual vacuolated structures in some of the secondary spermatocytes, spermatids and spermatozoa. Rsp-2/rsp-6 RNAi caused severe abnormalities in somatic gonad structures and in some cases animals were arrested or dead at the larval stage.

6239:CELE Y54G11A.7
gene id: 6239:CELE_Y54G11A.7
uniprot id: Q9XW01
names: Similarity
messages: Belongs to the TTC38 family.

6239:CELE F29G9.4
gene id: 6239:CELE_F29G9.4
uniprot id: G5ECG2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are sterile and display a protruding vulva phenotype (PubMed:17942488). Animals have uterine defects lacking both a uterine lumen and a utse-like process; subsequently fail to develop a differentiated uterus. Furthermore, uterine seam cell genes egl-13 and lin-11 are not expressed during late larval development (PubMed:17942488). At the L3 developmental stage, AC display either failed or delayed invasion leading to the defective removal of the gonadal basement-membrane (PubMed:15960981, PubMed:17488621). AC do not fuse (PubMed:17488621). AC specific expression of lin-3 is increased, but zmp-1, him-4 and aff-1 expression is undetectable and cdh-3 expression is reduced (PubMed:15960981, PubMed:17488621). RNAi-mediated knockdown of both isoforms results in sterility, a protruding vulva and exploded through the vulva phenotypes (PubMed:17942488, PubMed:19570917). Animals have an undifferentiated uterus and lack uterine egl-13 expression (PubMed:17942488). Animals also display an endomitotic oocytes phenotype, which is due to improper distal spermathecal valve dilation and reduced plc-1 expression in the spermatheca (PubMed:19570917). Animals have no mig-10b expression in AC (PubMed:24553288). RNAi-mediated knockdown of isoform b results in an everted/protruded vulval phenotype in adults (PubMed:23437011).
messages: Belongs to the bZIP family. Fos subfamily.
messages: Detected before the L2 molt stage (PubMed:15960981). Expressed throughout ventral uterine intermediate precursor cells (PubMed:17942488).
messages: Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3' (PubMed:23437011).
messages: Expressed in anchor cells (PubMed:15960981). Isoform a is expressed in somatic gonad cells that neighbor anchor cells (PubMed:15960981, PubMed:19570917). Isoform b is expressed in vulval cells, the uterine cells that neighbor anchor cells and the spermatheca (PubMed:15960981, PubMed:19570917).
messages: Homodimer (PubMed:23437011). Heterodimer; with jun-1 (PubMed:17942488). Interacts with kgb-1 and hda-1 (PubMed:23437011).
messages: May be phosphorylated by kgb-1. Phosphorylation at Thr-440 increases sensitivity to heavy metal stress. Phosphorylation inhibits homodimer formation, and promotes association with target promoters.
messages: Nucleus
messages: Plays a role the development of the reproductive system, controlling events including anchor cell (AC) fusion and invasion (PubMed:15960981, PubMed:17488621). Regulates downstream transcriptional targets, including zmp-1, cdh-3, him-4 and mig10b, to promote the removal of the gonadal basement membrane during AC invasion (PubMed:15960981, PubMed:24553288). Regulates aff-1 expression to promote AC fusion (PubMed:17488621). With jun-1 regulates egl-1 and lin-12 expression to allow uterine cell specification and development (PubMed:17942488).
messages: Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917). Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 (PubMed:23437011).

6239:CELE F26F4.7
gene id: 6239:CELE_F26F4.7
uniprot id: Q19818
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F26D10.3
gene id: 6239:CELE_F26D10.3
uniprot id: P09446
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: AMPylated by fic-1.
messages: Belongs to the heat shock protein 70 family.
messages: Induced by white light exposure.
messages: Interacts with E3 ubiquitin-protein ligase chn-1.

6239:CELE Y50E8A.6
gene id: 6239:CELE_Y50E8A.6
uniprot id: Q9NAF2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

6239:CELE C08B11.1
gene id: 6239:CELE_C08B11.1
uniprot id: P21541
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment.
messages: Belongs to the zyg-11 family.
messages: Interacts with elc-1. Part of an E3 ubiquitin ligase complex including zyg-11, cul-2 and elc-1.
messages: Maternally expressed but its transcription is not limited to the female germline.

6239:CELE Y73E7A.6
gene id: 6239:CELE_Y73E7A.6
uniprot id: G5EE03
names: Similarity
messages: Belongs to the BLCAP family.

6239:CELE K04G2.9
gene id: 6239:CELE_K04G2.9
uniprot id: Q21228
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C17E7.6
gene id: 6239:CELE_C17E7.6
uniprot id: O16389
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F56H1.4
gene id: 6239:CELE_F56H1.4
uniprot id: O76371
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including the PSMC3 homolog rpt-5 and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:27528192). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown results in larval arrest and up-regulation of the aspartic protease ddi-1, indicative of proteasomal dysfunction. RNAi-mediated knockdown in a ddi-1, png-1, sel-11 or sel-1 mutant background results in reduced or failed expression of the proteasomal subunit rpt-3.

6239:CELE Y73F8A.25
gene id: 6239:CELE_Y73F8A.25
uniprot id: A0A078BS59
uniprot id: A0A078BTL9
uniprot id: Q9NA34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE Y67H2A.4
gene id: 6239:CELE_Y67H2A.4
uniprot id: Q95PZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MICU1 family. MICU1 subfamily.
messages: Expressed at low levels in PLM touch receptor neurons, germ cells, epidermis, and muscles.
messages: Key regulator of mitochondrial calcium uniporter (MCU). Modulates the activity of the mitochondrial calcium uniporter protein mcu-1 depending on the level of intracellular calcium in PLM touch receptor neurons following axonal injury (PubMed:31983639).
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

6239:CELE ZK354.7
gene id: 6239:CELE_ZK354.7
uniprot id: P91567
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F37B4.8
gene id: 6239:CELE_F37B4.8
uniprot id: O45170
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C18G1.2
gene id: 6239:CELE_C18G1.2
uniprot id: O61924
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed highly during embryogenesis. Expressed in the endoderm in cells of the gut lineage beginning at the 2E cell stage (endodermal cell stage) of embryogenesis through to adulthood.
messages: Induced by P.aeruginosa infection.
messages: No obvious phenotype (PubMed:20807527). RNAi-mediated knockdown results in no obvious phenotype (PubMed:18448117). Following infection with P.aeruginosa, RNAi-mediated knockdown results in reduced survival and slight intestinal distension (PubMed:21168435). Double mutation with elt-2 results in arrest at the L1 stage of larval development, reduced expression of gut-specific genes and a severe disruption to normal gut differentiation with the absence of birefringent and rhabditin granules, which are characteristic of normal gut differentiation, largely at the regions of the cell that interface with the pharyngeal and rectal valves (PubMed:20807527). These mutants also have essentially no gut lumen, with only infrequent patches of lumen and brush border in few animals, and reduced gut epithelialization as indicated by reduced expression of epithelial markers erm-1b, itx-1 and ajm-1 (PubMed:20807527).
messages: Nucleus
messages: Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:26700680). Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527, PubMed:24257624). May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa (PubMed:21168435).

6239:CELE B0331.2
gene id: 6239:CELE_B0331.2
uniprot id: O45220
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

6239:CELE R07E3.5
gene id: 6239:CELE_R07E3.5
uniprot id: Q1ZXU8
uniprot id: Q21812
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE T05H4.13
gene id: 6239:CELE_T05H4.13
uniprot id: O16518
uniprot id: Q86S57
uniprot id: Q8MXJ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE B0303.8
gene id: 6239:CELE_B0303.8
uniprot id: P34259
names: Developmental Stage
names: Function
names: Miscellaneous
names: Tissue Specificity
messages: Down-regulated in 12-cell embryos from mutant worms lacking skn-1.
messages: Expressed in mesendodermal precursor cells of embryos.
messages: May have a role in mesendoderm development during embryogenesis.
messages: Tenfold increase in expression between 4-cell and 12-cell embryos.

6239:CELE Y71F9AL.17
gene id: 6239:CELE_Y71F9AL.17
uniprot id: Q9N4H7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

6239:CELE F47B10.2
gene id: 6239:CELE_F47B10.2
uniprot id: Q20502
names: Disruption Phenotype
names: PTM
names: Similarity
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.
messages: Defective histidine metabolism resulting in elevated histidine levels and resistance to nickel and zinc toxicity. Additionally, slightly resistant to copper, slightly sensitive to cobalt and iron and substantially sensitive to manganese.

6239:CELE T09A12.3
gene id: 6239:CELE_T09A12.3
uniprot id: O61220
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K08F8.1
gene id: 6239:CELE_K08F8.1
uniprot id: Q21360
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Autophosphorylated in vitro.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Expressed in body wall muscles (at protein level). Expressed in intestine.
messages: May interact (via protein kinase domain) with unc-22 (via protein kinase and CRD domains).
messages: Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin.
messages: Slight reduction in motility. Partially resistant to nicotine-induced paralysis; resistance is further increased in a mak-2 gk1110 mutant background. Normal localization of several components of the sarcomere including unc-52, unc-112, unc-95, atn-1,unc-89 and myo-3.
messages: sarcomere

6239:CELE T05C12.7
gene id: 6239:CELE_T05C12.7
uniprot id: P41988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE F10C2.6
gene id: 6239:CELE_F10C2.6
uniprot id: P90831
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

6239:CELE T19D12.9
gene id: 6239:CELE_T19D12.9
uniprot id: O76837
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C24B9.7
gene id: 6239:CELE_C24B9.7
uniprot id: O76435
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE ZC416.4
gene id: 6239:CELE_ZC416.4
uniprot id: H2KZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

6239:CELE T01C1.2
gene id: 6239:CELE_T01C1.2
uniprot id: G5EGQ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at the comma stage and throughout larval stages and in adult.
messages: Expressed in AIM, RIC, AIZ, ADF, ADL, ASK, AWA, AUA, AIN, RIH (or RIR) and RIF head neurons and, in PVP, PVQ and DVA (or DVC) tail neurons, some intestinal cells, somatic gonad and vulva.
messages: May act as transcription activator (By similarity). Plays a role in neurogenesis by regulating neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development (PubMed:16139210, PubMed:19561603). Regulates olfactory plasticity (PubMed:19561603).
messages: Nucleus
messages: The left and right AIM neurons and the left and right RIF neurons are connected by abnormal neurites in 40% and 80% of adults respectively (PubMed:16139210, PubMed:19561603). Fails to reduce chemotaxis to benzaldehyde after pre-exposure to benzaldehyde (PubMed:19561603). In mbr-1 and cam-1 double mutants, normal neurite pruning between left and right AIM neurons is restored (PubMed:19561603).

6239:CELE VF13D12L.1
gene id: 6239:CELE_VF13D12L.1
uniprot id: G5ED01
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

6239:CELE F46F11.1
gene id: 6239:CELE_F46F11.1
uniprot id: P91309
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
messages: The N-terminal kinase domain produces inositol polyphosphates. The C-terminal acid phosphatase-like domain binds inositol polyphosphates and negatively regulates their accumulation. The C-terminal domain reduces the amount of inositol pyrophosphates in a dose-dependent manner in vitro.
messages: cytosol

6239:CELE F15C11.1
gene id: 6239:CELE_F15C11.1
uniprot id: G5EFF4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sal C2H2-type zinc-finger protein family.
messages: Expressed throughout the mesodermal (M) lineage from the 1-M stage to the 18-M stage, and in the sex myoblast (SM) sub-lineage from the 2-SM stage to the 16-SM stage, before the cells differentiate (PubMed:28614700). Expression declines significantly in the differentiated coelomocytes (CC) and vulval muscles, but remains in the differentiated body-wall muscles (BWM) (PubMed:28614700). Expressed in the vulval precursor cells (VPC) during larval development (PubMed:10926783).
messages: Nucleus
messages: Transcription factor, involved in positive and negative modulation of transcription (PubMed:12835398, PubMed:28614700). Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3 (PubMed:12835398). Involved in cell-fate regulation in multiple lineages, including neuronal, mesodermal and vulval (PubMed:8756352, PubMed:28614700, PubMed:12835398, PubMed:10926783). Required to regulate the fate of PLM touch receptor neurons, acting via negative modulation of transcription of egl-5 and mec-3 (PubMed:12835398). May modulate gene expression by interacting with different transcription factors during neuronal and mesodermal cell development (PubMed:8756352). Promotes the proliferative sex myoblast (SM) fate, in a cell autonomous manner, acting via the SoxC transcription factor sem-2 (PubMed:28614700). Involved in vulval cell-fate determination, acting by regulating expression of homeobox protein lin-39, and may link lin-39 to incoming signaling pathways (PubMed:10926783). Plays a role in detoxification of reactive oxygen species (ROS), by regulating expression of transcription factor skn-1 and the phase II detoxification genes (PubMed:32718932).

6239:CELE F09E8.7
gene id: 6239:CELE_F09E8.7
uniprot id: C6KRN0
uniprot id: Q27218
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Interacts with unc-29. Component of nicotinic acetylcholine receptor composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine.
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis.
messages: Synaptic cell membrane

6239:CELE Y23H5B.5
gene id: 6239:CELE_Y23H5B.5
uniprot id: Q9N477
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE F17A2.9
gene id: 6239:CELE_F17A2.9
uniprot id: O17822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C31H5.6
gene id: 6239:CELE_C31H5.6
uniprot id: B3WFZ3
uniprot id: B3WFZ4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE DY3.1
gene id: 6239:CELE_DY3.1
uniprot id: O45319
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim-8/ddp-1 and 3 copies of tin-13/tim-13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim-22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tin-13/tim-13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

6239:CELE C06H2.4
gene id: 6239:CELE_C06H2.4
uniprot id: Q17766
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Folate transporter.
messages: Highly expressed in pharynx and posterior part of the intestine. Expressed at lower levels in the body wall muscles, head muscles, and vulva muscles. Highly expressed in the intestine of the early larva, levels decrease in the later stages of development.
messages: Membrane
messages: Worms display defects in folate uptake, reproduction and movement.

6239:CELE Y66A7A.2
gene id: 6239:CELE_Y66A7A.2
uniprot id: G5EF59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

6239:CELE ZK418.3
gene id: 6239:CELE_ZK418.3
uniprot id: Q23481
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H11E01.2
gene id: 6239:CELE_H11E01.2
uniprot id: O61803
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F49E2.4
gene id: 6239:CELE_F49E2.4
uniprot id: D0VWM4
uniprot id: Q20623
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K08E3.5
gene id: 6239:CELE_K08E3.5
uniprot id: Q69Z13
uniprot id: Q8WQE5
uniprot id: Q9XUS4
uniprot id: Q9XUS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

6239:CELE T07A9.7
gene id: 6239:CELE_T07A9.7
uniprot id: Q9BIG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE Y37E11AR.6
gene id: 6239:CELE_Y37E11AR.6
uniprot id: G5EEE7
uniprot id: U4PQX3
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R02E12.8
gene id: 6239:CELE_R02E12.8
uniprot id: Q21645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE Y113G7B.18
gene id: 6239:CELE_Y113G7B.18
uniprot id: Q9NAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE H23N18.3
gene id: 6239:CELE_H23N18.3
uniprot id: Q9TXZ4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y37E11AR.5
gene id: 6239:CELE_Y37E11AR.5
uniprot id: Q965X5
uniprot id: U4PLL6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F48F5.4
gene id: 6239:CELE_F48F5.4
uniprot id: Q9XV08
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE ZK287.1
gene id: 6239:CELE_ZK287.1
uniprot id: J7S127
uniprot id: Q23460
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

6239:CELE Y50D7A.7
gene id: 6239:CELE_Y50D7A.7
uniprot id: O45218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

6239:CELE C34C12.8
gene id: 6239:CELE_C34C12.8
uniprot id: Q18421
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
messages: Mitochondrion matrix
messages: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14/dnj-21.

6239:CELE B0348.4
gene id: 6239:CELE_B0348.4
uniprot id: A0A0K3ARR2
uniprot id: A0A0K3ARS4
uniprot id: A0A0K3AS74
uniprot id: A0A0K3AS85
uniprot id: A0A0K3AUL3
uniprot id: A0A0K3AUM3
uniprot id: A0A0K3AV83
uniprot id: A0A0K3AV97
uniprot id: A0A0K3AXH8
uniprot id: A0A0K3AXJ0
uniprot id: A0A0K3AXK2
uniprot id: G5EBH0
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 Ca(2+) ion per subunit.
messages: Expressed in most or all neurons with high expression in the head and tail ganglia and low expression in the motor neurons of the ventral cord. Expressed in the intestine (at protein level) (PubMed:10571227, PubMed:10571228). In males, expressed in vas deferens, spicule protractor muscles, diagonal muscles and a male-specific neuron (PubMed:15958491).
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion (PubMed:10571228). Plays a role in efficient egg laying and defecation (PubMed:10571227, PubMed:10571228, PubMed:24212673). Involved in axon regeneration after injury (PubMed:23072806). Plays a role in male mating behavior by regulating spicule insertion and sperm transfer (PubMed:15958491). By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch (PubMed:19730689). By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection (PubMed:19380113). During embryogenesis, may play a role in epidermal morphogenesis together with plc-1 (PubMed:18369461).
messages: Mutant worms are similar in size to the wild-type but animals are bloated with eggs due to defective egg laying with decreased body flexion and sluggish locomotion (PubMed:10571227, PubMed:10571228). They have defects in the posterior body contraction step of the defecation motor program and become sluggish in the presence of exogenous betaine (PubMed:24212673). Animals are resistant to aldicarb, a carbamate insecticide (PubMed:10571228). Simultaneous knockout of egl-8 and snf-3 results in uncoordinated, hypercontracted and paralyzed animals (PubMed:24212673). RNAi-mediated knockdown causes a defect in sperm transfer and a slight defect in spicule protrusion resulting in male infertility (PubMed:15958491). Ca(2+) transient increase and avoidance behavior are defective in response to nose touch but not to benzaldehyde (PubMed:19730689). nlp-29 expression is abrogated following fungal infection by D.coniospora but not following physical injury (PubMed:19380113). Causes a 1.6 fold increase in embryonic arrest in a plc-1 (tm753) mutant background (PubMed:18369461).
messages: Perikaryon
messages: Synapse
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
messages: adherens junction
messages: axon

6239:CELE T26E4.16
gene id: 6239:CELE_T26E4.16
uniprot id: Q7YWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK177.5
gene id: 6239:CELE_ZK177.5
uniprot id: Q09660
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE F56A8.7
gene id: 6239:CELE_F56A8.7
uniprot id: O16000
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Cell membrane
messages: Expressed throughout the head ganglion, nerve ring, ventral cord, dorsal cord, intestine, vulva and spermatheca.
messages: Interacts (via N-terminus, in open or in closed conformation) with unc-18; the interaction is direct (PubMed:9442061, PubMed:8939465, PubMed:10366611, PubMed:18596236, PubMed:19032153). Interaction in open conformation with unc-18 promotes synaptic vesicle docking and tethering (PubMed:21423527). Interaction via N-terminus with unc-18 mediates the secretion of the neurotransmitter acetylcholine from cholinergic motor neurons (PubMed:18596236). Interaction with unc-18 is reduced in the presence of unc-13 (PubMed:10366611).
messages: Perikaryon
messages: Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:1945043, PubMed:9442061). Plays a role in synaptic vesicle docking and tethering through its association with unc-18 (PubMed:21423527). Through binding to unc-18 mediates the release of the neurotransmitter acetylcholine from cholinergic motor neurons, and thereby promotes locomotory behaviors (PubMed:18596236). Essential for embryonic viability and development. Has a role in dauer formation and adult life span (PubMed:10377425). Required for locomotion (PubMed:10377425). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142).
messages: Worms exhibit defects in locomotion and postembryonic development. All mutants are resistant to the acetylcholinesterase inhibitor aldicarb indicating impaired cholinergic transmission.
messages: axon
messages: dendrite

6239:CELE C01G12.8
gene id: 6239:CELE_C01G12.8
uniprot id: G5EFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

6239:CELE T12A2.10
gene id: 6239:CELE_T12A2.10
uniprot id: P46566
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE W04G3.6
gene id: 6239:CELE_W04G3.6
uniprot id: G5EC30
uniprot id: G5EE27
uniprot id: G5EFX9
uniprot id: G5EGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE F15D3.1
gene id: 6239:CELE_F15D3.1
uniprot id: Q9TW65
uniprot id: V6CJD7
uniprot id: V6CKJ6
uniprot id: V6CLR8
uniprot id: V6CLV8
uniprot id: V6CLW7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the dystrophin glycoprotein complex (DGC). Interacts with dyb-1 and stn-1 to form the DGC. Interacts with stn-2.
messages: Expressed in body wall, head, pharyngeal and vulval muscles, from late embryogenesis to adulthood (at protein level).
messages: Mutants display a phenotype of hyperactive locomotion and are hypersensitive to the acetylcholinesterase inhibitor aldicarb and are defective in maintaining neuronal positioning. Dys-1 and hlh-1 double mutants synergistically exhibit progressive myopathy.
messages: Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
messages: cytoskeleton
messages: sarcolemma

6239:CELE R09B5.11
gene id: 6239:CELE_R09B5.11
uniprot id: O44616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears to have no transport activity for glucose.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in seam cells from the early embryonic stage through the L2 stage (at protein level).

6239:CELE F22E12.4
gene id: 6239:CELE_F22E12.4
uniprot id: G5EBV0
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation (PubMed:11595184). In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity (PubMed:19737748). By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli (PubMed:20011506, PubMed:16091039). Mediates susceptibility to P.aeruginosa PAO1-mediated killing by regulating resistance to cyanide produced by P.aeruginosa (PubMed:10611362, PubMed:11591663, PubMed:20865124). Mediates resistance to S.aureus-mediated killing (PubMed:22792069). In addition, plays a role in heat acclimation, neuronal development, behavioral responses to reoxygenation and hydrogen sulfide, iron homeostasis and aging (PubMed:12686697, PubMed:18477695, PubMed:22405203, PubMed:19372390, PubMed:22396654). In neurons, involved in mitochondrion fusion during reoxygenation (PubMed:24385935). Involved in egg laying (PubMed:10611362, PubMed:11813735).
messages: Cytoplasm
messages: In larvae and adults, expressed in pharyngeal and body wall muscles.
messages: Induced by hypoxia.
messages: Inhibited by Co(2+) and dimethyloxalylglycine (PubMed:11595184). Inhibited by the iron chelator 2, 2'-dipyridyl (PubMed:19737748).
messages: Interacts (via catalytic domain) with lin-10 (via N-terminus); the interaction regulates lin-10 subcellular localization; the interaction is direct (PubMed:22252129). Interacts (via catalytic domain) with swan-1 (via WD 1-3 repeats); the interaction may regulate vhl-1-independent hif-1 transcriptional activity; the interaction is direct (PubMed:20865124). Interacts (via C-terminus) with cysl-1; the interaction is enhanced by hydrogen disulfide and activates hif-1-mediated transcription; the interaction is direct (PubMed:22405203).
messages: Nucleus
messages: RNAi-mediated knockdown causes enhanced resistance to polyglutamine or amyloid-beta-mediated paralysis and an increase in adult life span (PubMed:19372390). In addition, causes resistance to B.thuringiensis pore-forming toxin CryA21-mediated toxicity (PubMed:20011506).
messages: Regulates the trafficking of the glutamate receptor glr-1, probably independently of hif-1, by regulating lin-10 subcellular localization in response to oxygen levels. May hydroxylate lin-10.
messages: The MYND-type domain is not required for oxygen-mediated hif-1 degradation or for inhibiting hif-1 transcriptional activity (PubMed:19737748). Susceptibility to S.aureus infection requires the Ser-rich region but not the MYND-type or Fe2OG dioxygenase domains (PubMed:22792069).
messages: axon
messages: dendrite

6239:CELE F35H10.11
gene id: 6239:CELE_F35H10.11
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F47A4.1
gene id: 6239:CELE_F47A4.1
uniprot id: G5EC54
uniprot id: G5EEX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F25E2.3
gene id: 6239:CELE_F25E2.3
uniprot id: Q19781
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE Y55F3AR.3
gene id: 6239:CELE_Y55F3AR.3
uniprot id: Q9N358
uniprot id: U4PBK9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex.
messages: Low and diffuse subcellular localization of pgl-1 in embryos rather than confined to granules in somatic cells.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Required for correct subcellular localization of pgl-1.

6239:CELE C36H8.3
gene id: 6239:CELE_C36H8.3
uniprot id: Q18502
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: Expressed in eggs and larvae, but not in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: KPSFVRF-amide: Has no effect on somatic body wall muscle, inhibits contraction of vaginal vera muscle, and inhibits the activity of the dissected pharyngeal myogenic muscle system (PubMed:9920762, PubMed:16187307). Acts as a ligand for the npr-22 receptor in vitro (PubMed:16377032).
messages: Secreted

6239:CELE C29A12.4
gene id: 6239:CELE_C29A12.4
uniprot id: A7UQ09
uniprot id: I2HAJ6
uniprot id: I2HAJ7
uniprot id: Q18291
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C26F1.10
gene id: 6239:CELE_C26F1.10
uniprot id: Q18234
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Exacerbates bordering behavior, where animals accumulate at the edges of culture media (PubMed:14555955). Enhances clumping/aggregation behavior in a G-protein coupled receptor npr-1 mutant background (PubMed:14555955). Decreases locomotion quiescence, in an npr-1 mutant background, during the sleep-like state called lethargus which occurs during molting between larval and adult stages (PubMed:23764289).
messages: Expressed in the ADL, ASE and ASH sensory neurons, the URA motor neurons and the MC, M2 and M4 pharyngeal neurons.
messages: FMRFamide-like neuropeptide (PubMed:12821653, PubMed:14555955). Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via the G-protein coupled receptor npr-1 (PubMed:23764289). Plays a role in modulating social and feeding behavior (PubMed:14555955).
messages: It has been reported that many phenotypes associated with the Bristol N2 reference allele of the receptor npr-1 may reflect a neomorphic gain-of-function sensitivity of the receptor to flp-18 in addition to sensitivity to flp-21.
messages: Ligand to G-protein coupled receptor npr-1.
messages: May be processed by convertase egl-3.
messages: Secreted

6239:CELE C01C10.1
gene id: 6239:CELE_C01C10.1
uniprot id: Q11085
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clc family.
messages: Expressed throughout development.
messages: Membrane

6239:CELE ZK131.1
gene id: 6239:CELE_ZK131.1
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T20D4.1
gene id: 6239:CELE_T20D4.1
uniprot id: P91475
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C52E4.3
gene id: 6239:CELE_C52E4.3
uniprot id: Q18786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: cytosol

6239:CELE R102.5
gene id: 6239:CELE_R102.5
uniprot id: Q9U389
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells.
messages: Cytoplasm
messages: Expressed in oocytes, but not in spermatozoa.
messages: Phosphorylation on Thr-74 by ikke-1 is required for allophagic function.
messages: Self-associates. Interacts (via N-terminus) with ikke-1; the interaction is direct. Interacts (via the LIR motif) with lgg-1. Interacts (via C-terminus) with ubiquitinated proteins.
messages: The C-terminal region is required for localization to paternal organelles.

6239:CELE T05G5.8
gene id: 6239:CELE_T05G5.8
uniprot id: P34561
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843).
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-51, vps-52 and vps-54 (PubMed:21613545).
messages: Endosome membrane
messages: Mutants are viable but display reduced brood size and enlarged lysosomes (PubMed:21613545). Egg-laying defect, slow, but coordinated locomotion, and reduced levels of unprocessed and processed cargo in the motor neuron axon of the dorsal nerve cord (PubMed:27191843).
messages: Perikaryon
messages: Ubiquitously expressed, with particularly strong expression in neuronal cells (PubMed:21613545). Specifically expressed in head and tail neurons and in the pharynx and ventral cord motor neurons (PubMed:27191843).
messages: perinuclear region
messages: trans-Golgi network membrane

6239:CELE R13A5.11
gene id: 6239:CELE_R13A5.11
uniprot id: A0A0K3AU53
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F35H8.6
gene id: 6239:CELE_F35H8.6
uniprot id: Q20086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y57G11C.17
gene id: 6239:CELE_Y57G11C.17
uniprot id: O18241
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F41G3.12
gene id: 6239:CELE_F41G3.12
uniprot id: G5EG68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y54E10BL.5
gene id: 6239:CELE_Y54E10BL.5
uniprot id: Q9N3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE B0414.8
gene id: 6239:CELE_B0414.8
uniprot id: O01839
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843).
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-53 (PubMed:21613545).
messages: Mutants are viable but have enlarged lysosomes (PubMed:21613545). Egg-laying defect, slow, but coordinated locomotion, and reduced levels of unprocessed and processed cargo in the motor neuron axon of the dorsal nerve cord (PubMed:27191843).
messages: Ubiquitously expressed, with particularly strong expression in neuronal cells.
messages: trans-Golgi network

6239:CELE C29F7.5
gene id: 6239:CELE_C29F7.5
uniprot id: O17617
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage (PubMed:12568714). Expressed in all descendents of the AB and EMS founder cells (PubMed:12568714).
messages: Nucleus
messages: RNAi-mediated knockdown causes significant reduction in the expression of 21U-RNAs, upon simultaneous knockdown of fkh-3 and fkh-5.
messages: Transcription factor (By similarity). Regulates expression of a class of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-3 and fkh-5 (PubMed:22819322).

6239:CELE C41D11.8
gene id: 6239:CELE_C41D11.8
uniprot id: Q95NM6
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA/RNA non-specific endonuclease family.
messages: Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.
messages: Homodimer; disulfide-linked (By similarity). Interacts with crn-5, crn-4, crn-1 and cyn-13 (PubMed:12718884).
messages: Mitochondrion
messages: RNAi-mediated knockdown results in accumulation of apoptotic DNA in 1.5-fold stage embryos and delayed appearance of embryonic cell corpses during development.
messages: The active site contains 1 hydrated magnesium ion that has only 1 direct interaction with the protein; all other interactions are via water molecules.

6239:CELE C44C1.5
gene id: 6239:CELE_C44C1.5
uniprot id: G8JY22
uniprot id: Q18610
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

6239:CELE Y47D3A.10
gene id: 6239:CELE_Y47D3A.10
uniprot id: Q9NAH2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F59H6.7
gene id: 6239:CELE_F59H6.7
uniprot id: Q7Z134
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE ZK678.1
gene id: 6239:CELE_ZK678.1
uniprot id: Q27365
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Greatly reduced nuclear accumulation of lin-56 protein and increased mRNA levels (PubMed:21196525). No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class B protein lin-15B, dpl-1, efl-1 or lin-35 results in a multiple vulva (Muv) phenotype (PubMed:8054684, PubMed:11463372, PubMed:16624904).
messages: Nucleus
messages: Synthetic multivulva (synMuv) class A protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684). Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway (PubMed:8054684, PubMed:16624904). May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1 (PubMed:11463372). Regulates let-23 basal activity (PubMed:8054684). Required for the correct expression and/or stability of lin-56 (PubMed:21196525).
messages: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.

6239:CELE F21D5.7
gene id: 6239:CELE_F21D5.7
uniprot id: G5EE80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

6239:CELE Y73B6BL.9
gene id: 6239:CELE_Y73B6BL.9
uniprot id: P15796
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: H1.2 is a minor form.
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

6239:CELE T23D8.5
gene id: 6239:CELE_T23D8.5
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F55G1.4
gene id: 6239:CELE_F55G1.4
uniprot id: Q20849
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RZZ complex composed of rod-1, czw-1 and zwl-1 (PubMed:18765790). Interacts (via N-terminus) with NDC80 complex component ndc-80 (PubMed:24231804).
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:11590237, PubMed:18765790). Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790, PubMed:19109417). Plays a role in nuclear envelope breakdown (PubMed:19109417). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790, PubMed:24231804). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790, PubMed:24231804). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:11590237, PubMed:18765790, PubMed:19109417).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:11590237, PubMed:18765790, PubMed:19109417). RNAi-mediated knockdown results in defects in mitosis which include the formation of chromatin bridges in between sister chromatids during anaphase (PubMed:11590237). There is also defective chromosome segregation, premature spindle pole separation and incorrectly attached kinetochores (PubMed:18765790). In addition, localization of the spindly-like protein spdl-1 and the other Rzz complex components czw-1 and zwl-1 to the kinetochore is abolished (PubMed:18765790).
messages: kinetochore
messages: spindle

6239:CELE C47E12.7
gene id: 6239:CELE_C47E12.7
uniprot id: Q18674
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP1 family.
messages: May be involved in the generation of 28S rRNA.
messages: Nucleus

6239:CELE W06H8.8
gene id: 6239:CELE_W06H8.8
uniprot id: G4SLH0
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Expression begins at 2.5-fold stage and continues throughout adulthood.
messages: Expression is restricted to body wall, enteric and vulval muscles.
messages: I band
messages: Interacts (via C-terminus) with myosin. Interacts with actin.
messages: Nucleus membrane
messages: Produced by alternative promoter usage and alternative splicing of isoform 301kDa_1.
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform g.
messages: Serine/threonine-protein kinase (PubMed:18390597, PubMed:20346955). Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity).
messages: The BLUE region may serve as a force and thermal sensors.
messages: The PEVK region may serve as an entropic spring to bear the passive tension of the sarcomere.
messages: The autoinhibitory domain may interact with the kinase catalytic core thereby preventing its activation.

6239:CELE Y106G6H.15
gene id: 6239:CELE_Y106G6H.15
uniprot id: Q9XWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA1 family.
messages: Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (By similarity). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:23085020).
messages: Component of the ska-1 complex, composed of two copies of ska-1 and a single copy of ska-3. The core complex associates with microtubules and may form dimeric assemblies. Interacts with ska-3 and microtubules.
messages: kinetochore
messages: spindle

6239:CELE T20D4.3
gene id: 6239:CELE_T20D4.3
uniprot id: A0A131MB53
uniprot id: A0A131MBP8
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE ZK593.6
gene id: 6239:CELE_ZK593.6
uniprot id: E2JKY9
uniprot id: Q23536
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG8 family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during embryogenesis.
messages: May interact with vps-39 (PubMed:24374177). Interacts with lgg-3; the interaction is direct (PubMed:26687600). Interacts with atg-16.1 (via WD domain) and atg-16.2 (via WD 5-6 repeats); the interactions are direct (PubMed:26687600). Interacts with sepa-1 (via the LIR motifs); the interaction is direct (PubMed:26687600). Interacts with sqst-1 (via the LIR motifs); the interaction is direct (PubMed:26687600). Interacts with epg-2 (via the LIR motifs); the interaction is weak (PubMed:26687600). Interacts with atg-7; the interaction is direct (PubMed:26687600). Interacts with atg-3 (PubMed:26687600). The interaction with atg-7 and atg-3 may be required for the lipidation of lgg-2 (PubMed:26687600).
messages: This protein is subject to lipidation (PubMed:26687600). Lipidation is regulated by lgg-1 (PubMed:26687600).
messages: Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes) (PubMed:26687600). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion (PubMed:26687600). Less effective at promoting membrane fusion than lgg-1 (PubMed:26687600). Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation (PubMed:26687600). In particular binds to components of an atg-5-lgg-3-atg-16 complex to regulate autophagosome formation and cargo sequestration (PubMed:26687600). Required for the degradation of specific sqst-1-containing aggregates during embryogenesis and the early stages of larval development (PubMed:26687600). Involved in allophagy, which is an autophagic process in which paternal mitochondria and organelles are degraded during fertilization, and moreover is required for the degradation of lgg-1-positive allophagic autophagosomes in embryos (PubMed:25126728, PubMed:24374177). Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098). Also plays a role in membrane-pore repair (PubMed:27875098). Through HOPS complex subunit vps-39, tethers lysosomes with autophagosomes to form autolysosomes (PubMed:24374177). Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells to ensure exclusive localization of the P-granules in germ cells (PubMed:19167332). Essential for dauer development and life-span extension (PubMed:20523114).
messages: Viable with no visible defects in development or fertility (PubMed:24374177). Embryos contain an increased number of endosomes (PubMed:25126728). Lysosomes have a reduced capacity to interact with autophagosomes in embryos and furthermore, there is defective autophagosome degradation with an accumulation of lgg-1-positive autophagosomes in 500-cell embryos (PubMed:24374177). Double knockout with rab-7 partially rescues the defective lgg-1- and lgg-2-positive autophagosome degradation defect in the individual rab-7 and lgg-2 single mutants (PubMed:24374177). RNAi-mediated knockdown results in the accumulation of germ cell specific P-granules in somatic cells as indicated by increased numbers of pgl-1 positive granules in embryos (PubMed:19167332). RNAi-mediated knockdown reduces autophagic degradation of membrane pore-forming toxin Cry5B.
messages: autophagosome

6239:CELE T20H4.5
gene id: 6239:CELE_T20H4.5
uniprot id: Q22619
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion

6239:CELE C33D12.1
gene id: 6239:CELE_C33D12.1
uniprot id: Q22910
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in PVR neurons.
messages: Nucleus
messages: Required for cell specification of the glutamergic PVR neuron.

6239:CELE F18E3.5
gene id: 6239:CELE_F18E3.5
uniprot id: Q19562
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0212.4
gene id: 6239:CELE_B0212.4
uniprot id: H2KY64
uniprot id: Q95X47
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F20A1.9
gene id: 6239:CELE_F20A1.9
uniprot id: Q19614
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the germline.

6239:CELE B0218.2
gene id: 6239:CELE_B0218.2
uniprot id: Q17447
names: Similarity
messages: Belongs to the amidase family.

6239:CELE H37A05.1
gene id: 6239:CELE_H37A05.1
uniprot id: Q9XXT5
names: Similarity
messages: Belongs to the lipin family.

6239:CELE T27B1.2
gene id: 6239:CELE_T27B1.2
uniprot id: Q22829
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Chromosome
messages: Expressed from early embryogenesis and throughout all developmental stages (at protein level) (PubMed:22616817). Expressed in body wall muscle in embryos, young larvae and adults (at protein level) (PubMed:22616817).
messages: Expressed in body wall muscle and gonad (at protein level).
messages: Nucleus
messages: Probable transcription factor; required for proper organization of muscle myofilaments and for their recruitment to the M line.
messages: RNAi-mediated knockdown causes paralysis and arrested elongation at the two-fold stage of embryonic development.

6239:CELE Y50E8A.7
gene id: 6239:CELE_Y50E8A.7
uniprot id: Q9U276
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

6239:CELE F56F3.5
gene id: 6239:CELE_F56F3.5
uniprot id: P48154
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm

6239:CELE M02A10.2
gene id: 6239:CELE_M02A10.2
uniprot id: A0A1C3NSR3
uniprot id: D3YT08
uniprot id: H2KYE6
uniprot id: U4PSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

6239:CELE Y39A1A.6
gene id: 6239:CELE_Y39A1A.6
uniprot id: Q9XX18
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

6239:CELE F56C11.6
gene id: 6239:CELE_F56C11.6
uniprot id: H2L069
uniprot id: Q86S38
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE Y54G2A.38
gene id: 6239:CELE_Y54G2A.38
uniprot id: Q60F72
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0395.3
gene id: 6239:CELE_B0395.3
uniprot id: Q17499
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE ZK652.1
gene id: 6239:CELE_ZK652.1
uniprot id: P34659
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

6239:CELE F40F11.1
gene id: 6239:CELE_F40F11.1
uniprot id: Q20206
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

6239:CELE B0035.6
gene id: 6239:CELE_B0035.6
uniprot id: Q17436
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic granule
messages: May interact with deps-1 and prg-1.
messages: Plays a role in regulating deps-1 cluster formation in the germline.
messages: RNAi-mediated knockdown results in enlarged deps-1-containing clusters.

6239:CELE C13A2.5
gene id: 6239:CELE_C13A2.5
uniprot id: O16873
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE W01G7.4
gene id: 6239:CELE_W01G7.4
uniprot id: Q9XVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

6239:CELE T07A9.11
gene id: 6239:CELE_T07A9.11
uniprot id: Q1XFY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

6239:CELE C10H11.6
gene id: 6239:CELE_C10H11.6
uniprot id: B1Q250
uniprot id: H2KYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE T08G5.5
gene id: 6239:CELE_T08G5.5
uniprot id: Q1ZXS5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAM6/VPS39 family.
messages: Cytoplasm
messages: In 1-cell to 20-cell stage embryos, there is defective autophagosome degradation with an accumulation of endosomes, lgg-1- and lgg-2-positive autophagosomes, amphisomes and paternal mitochondria close to the nuclei (PubMed:25126728, PubMed:24374177). Reduced number of gut granules in the adult intestine (PubMed:24501423). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in the formation of large late endosomes/lysosomes, but with simultaneous expression of rab-5- and rab-7-positive vesicles on the basal side of gut cells (PubMed:25273556).
messages: Late endosome
messages: Late endosome membrane
messages: Lysosome
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:24374177). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (By similarity). Required for fusion of endosomes (By similarity). In association with lgg-2 mediates the tethering of autophagosomes with lysosomes to form autolysosomes (PubMed:25126728, PubMed:24374177). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423).
messages: Probable core component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41 (By similarity). May interact with lgg-2 (PubMed:24374177). Interacts with cuti-1 (PubMed:19357781).

6239:CELE F32G8.4
gene id: 6239:CELE_F32G8.4
uniprot id: Q19978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Membrane

6239:CELE Y34D9B.1
gene id: 6239:CELE_Y34D9B.1
uniprot id: G5EF44
uniprot id: Q9N532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

6239:CELE EGAP2.3
gene id: 6239:CELE_EGAP2.3
uniprot id: Q19076
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acid phosphatase required for normal growth and development. Specifically required for normal gut differentiation.
messages: Belongs to the histidine acid phosphatase family.
messages: Expressed from late embryogenesis onwards (PubMed:1652526, PubMed:15733671). Temporally expressed in anterior and posterior cells of the intestine in newly hatched larvae (PubMed:15733671).
messages: Expressed in the intestine, specifically on the edge of the gut lumen, in the 14 posterior cells of the intestine.
messages: Homodimer.
messages: Membrane
messages: RNAi-mediated knockdown results in a maternal effect phenotype whereby the majority of F1 progeny of the RNAi-treated animals survive to adulthood, however 80-100% of F2 embryos arrest during embryogenesis.
messages: The N-terminus is blocked.

6239:CELE ZK637.9
gene id: 6239:CELE_ZK637.9
uniprot id: P30636
names: Function
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.
messages: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Functions cell non-autonomously.

6239:CELE Y39B6A.29
gene id: 6239:CELE_Y39B6A.29
uniprot id: F3Y5S6
uniprot id: Q9NEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C08E8.2
gene id: 6239:CELE_C08E8.2
uniprot id: O62040
names: Similarity
messages: Belongs to the strictosidine synthase family.

6239:CELE K03D7.2
gene id: 6239:CELE_K03D7.2
uniprot id: O62300
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K08F4.7
gene id: 6239:CELE_K08F4.7
uniprot id: Q21355
names: Function
names: Induction
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: By paraquat. Induced by white light exposure (PubMed:29500338).
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).

6239:CELE K11D12.10
gene id: 6239:CELE_K11D12.10
uniprot id: A0A0K3AV08
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activated by phosphorylation at Ser-355 (PubMed:20008556). May be activated by svh-2-mediated phosphorylation (PubMed:23072806, PubMed:22388962).
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Expressed in pharynx, intestine, hypodermis, neurons and body muscles.
messages: Interacts with max-2; the interaction is independent of max-2 and mlk-1 kinase activities (PubMed:20008556). May interact (via NPQY motif when phosphorylated on tyrosine residue) with shc-1 (via PID domain); the interaction may facilitate mek-1 phosphorylation by bringing mlk-1 and mek-1 together (PubMed:18809575). Interacts with svh-2 (via cytoplasmic domain) (PubMed:22388962). Interacts with tpa-1 (PubMed:23072806).
messages: May be phosphorylated on tyrosine residues by svh-2.
messages: May be ubiquitinated and targeted for proteasomal degradation by E3 ubiquitin ligase rpm-1.
messages: Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:20008556). Involved in the response to environmental stress such as heavy metals (PubMed:15116070, PubMed:18809575). By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury (PubMed:21670305, PubMed:23072806, PubMed:22388962).

6239:CELE C06A6.5
gene id: 6239:CELE_C06A6.5
uniprot id: Q17688
names: Domain
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen
messages: The thioredoxin domain lacks the 2 redox-active Cys. This strongly suggests that it lacks thioredoxin activity.

6239:CELE ZK84.6
gene id: 6239:CELE_ZK84.6
uniprot id: P56174
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed by ASI and ASJ sensory neurons.
messages: May be processed by serine endoprotease bli-4.
messages: Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions (PubMed:23665919). Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions (PubMed:24671950). Acts on AWC sensory neurons to regulate high salt chemotaxis responses (PubMed:24013594).
messages: Secreted
messages: Severe reduction in Ca(2+) signal in AWC neuron and in chemotaxis in response to high salt concentrations.

6239:CELE Y37E11B.5
gene id: 6239:CELE_Y37E11B.5
uniprot id: Q9TYN2
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

6239:CELE C14B1.4
gene id: 6239:CELE_C14B1.4
uniprot id: Q17963
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat WDR5/wds family.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with cfp-1, ash-2, dpy-30 and hda-1 (PubMed:31602465). Interacts with histone H3 both unmethylated and methylated at 'Lys-4' (PubMed:21455483). Interacts with jmjd-3.1, ceh-6, sox-2, sem-4 and egl-27 (PubMed:25124442). Interacts with set-2 (PubMed:21527717).
messages: Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483). Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813, PubMed:21527717). Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:17967446, PubMed:20555324, PubMed:28379943). Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446). Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446). Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813). Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813). Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Detected from the 20 cell embryo stage and continues through to adult, although in a restricted manner.
messages: Enriched in the germline (PubMed:17967446, PubMed:24682813). Detected in all nuclei of the embryo (PubMed:17967446). In larvae, expression is detected in the nuclei of seam cells, somatic gonad precursor cells Z1 and Z4, vulval precursor cells, distal tip cells, hypodermal cells, intestinal and muscle cells (PubMed:17967446). Also detected in the neurons from the ventral nerve cord, head and tail region (PubMed:17967446). Expressed in the head and tail region, intestinal cells, muscle cells, cells of the vulva, spermatheca and sheath cells in adults (PubMed:17967446).
messages: Increase in life span (PubMed:17967446). Longer time span to reach adulthood and reduced brood size resulting in sterility between generations F3 and F4 (PubMed:17967446). Associated embryonic lethality and additional somatic defects at elevated temperatures (PubMed:17967446). Defects in germ cells including defective sperm development and endomitotic oocytes (PubMed:17967446, PubMed:24682813). Significantly reduced H3 'Lys-4' trimethylation in both embryonic and adult germ cells in a sex-independent manner (PubMed:17967446). Increased fog-3 expression at 20 degrees Celsius (PubMed:24682813). At 20 and 25 degrees Celsius, double knockdown mutants with wdr-5.2 have increased fog-3 expression (PubMed:24682813). At 25 degrees Celsius, these mutants have increased wdr-5.2 and fog-1 expression, reduced brood size accompanied by 42% embryonic lethality with 100% of the surviving progeny being sterile (PubMed:24682813). Surviving progeny display enhanced defects in the spermatogenesis to oogenesis transition compared to the single wdr-5.1 knockout with 88% of the gonads only containing sperm (PubMed:24682813). The remaining germ cells in the gonads switch to oogenesis, but the oocytes display either an endoreplication or endomitotic phenotype (PubMed:24682813). Germ cells also have increased expression of the sex determining factor tra-1 in the cytoplasm and as a result there is reduced binding of tra-1 to the fog-3 promoter (PubMed:24682813). RNAi-mediated knockdown leads to an enrichment of mono-unsaturated fatty acids (PubMed:28379943).
messages: Nucleus

6239:CELE B0511.12
gene id: 6239:CELE_B0511.12
uniprot id: G4RT15
uniprot id: O61825
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C01B12.3
gene id: 6239:CELE_C01B12.3
uniprot id: O17206
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE T03D8.3
gene id: 6239:CELE_T03D8.3
uniprot id: Q9XTY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

6239:CELE C48D1.3
gene id: 6239:CELE_C48D1.3
uniprot id: O02228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Detected in the nervous system, including the nerve ring and cholinergic motor neurons of the ventral nerve cord.
messages: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
messages: Membrane

6239:CELE F39B1.1
gene id: 6239:CELE_F39B1.1
uniprot id: G5EDY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cytoplasm
messages: Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes.
messages: phagocytic cup
messages: phagosome membrane

6239:CELE T01G5.2
gene id: 6239:CELE_T01G5.2
uniprot id: O18009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE T19B10.1
gene id: 6239:CELE_T19B10.1
uniprot id: G5EC97
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C01H6.5
gene id: 6239:CELE_C01H6.5
uniprot id: P41828
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Expressed in all blastomeres of the embryo from at least the 2-cell stage until approximately the 200-cell stage (at protein level) (PubMed:9521900). Expression becomes restricted mainly to epidermal cells and their precursors after 200 cell stage and during subsequent embryogenesis (at protein level) (PubMed:9521900). Expressed at high levels in newly hatched larvae, then decreases to a minimum at 4-6 hr after L1 stage larvae start feeding; expression increases for about 2 hr and decreases before each successive molt (PubMed:11416209). In L4 larvae, expressed in hypodermal cells of the head, vulval precursor cells of hermaphrodites, and hypodermal and tail cells of males (PubMed:33060131). Also expressed in the sperm-producing germlines of males and L4 hermaphrodites, but not in hermaphrodites producing only oocytes (PubMed:33060131).
messages: Expressed in the germline and oocytes and is a maternal gene product (PubMed:9521900). In males and sperm-producing hermaphrodites, expressed in early pachytene spermatocytes, increasing in level throughout late pachytene (PubMed:33060131). Expression is undetectable in meiotically dividing spermatocytes or mature spermatids (PubMed:33060131).
messages: Nucleus
messages: Orphan nuclear receptor. Transcription factor (PubMed:9521900, PubMed:21910973, PubMed:11416209, PubMed:35968765). Modulates expression of target genes, such as Period protein homolog lin-42 and microRNA let-7, by binding to hormone response elements (HRE) (PubMed:9521900, PubMed:35968765). Involved in promoting oscillatory expression of the primary transcripts of let-7 and paralogous microRNAs miR-48, miR-84, and miR-241 (PubMed:35968765). Plays a role in normal development and required to regulate each larval molt (PubMed:9521900, PubMed:11416209, PubMed:21910973). Involved in regulating both the frequency and number of molts, acting as part of a negative feedback loop with the let-7 family of microRNAs, perhaps contributing to a self-sustaining molecular-genetic oscillator (PubMed:35968765). Positively modulates expression of collagen and hedgehog-related genes (PubMed:21910973, PubMed:11416209). Involved in development of the gonad and associated epidermal structures (PubMed:11416209, PubMed:9521900). Required in spermatogenesis, acting following the sperm/oocyte cell fate decision, downstream of the canonical sex-determination pathway (PubMed:33060131). Involved in regulating formation of the sperm-specific fibrous body-membranous organelle (FB-MO) complexes, acting independently of transcription regulator spe-44 (PubMed:33060131).
messages: Post-transcriptionally repressed by let-7 microRNAs.
messages: RNAi-mediated knockdown in the adult causes abnormally small larval progeny, difficulties in shedding old cuticles after molts and larval arrest at the L3 or L4 stage (PubMed:9521900). Up to three previous cuticle segments may remain attached near the tail (PubMed:9521900). Less than 1% of affected larvae survive to adulthood and in all cases have a strong Dumpy (short and fat) phenotype (PubMed:9521900). Defects in gonad morphogenesis and seam cell (lateral epidermis) development (PubMed:9521900). Knockdown in L1 larvae causes the majority of affected individuals to have defects in the L3/L4 molt (PubMed:11416209, PubMed:35968765). Reduces the peak level of expression of fbn-1 by 2-fold during both L3 and L4 stages (PubMed:35968765). Knockdown in L2 larvae results in a molting defect mainly at the L4/adult (A) transition (PubMed:11416209). Knockdown in L3 larvae causes developmental arrest and a molting defect in the L4/A molt (PubMed:11416209). Larval molting cycles are extended; this effect is partially suppressed in a microRNA let-7 mutant background (PubMed:35968765). Those hermaphrodite adults which survive knockdown at larval stages show defects in gonad development, with gonad often appearing misshapen, folded and constricted (PubMed:11416209). Males which survive knockdown often have tail morphogenesis defects, in addition to molting defects (PubMed:11416209). Significantly (5-11 fold) reduces level of expression of cuticle collagen dpy-7 (PubMed:11416209). Germline-targeted knockdown in hermaphrodites or males causes sterility (PubMed:33060131). Primary spermatocytes arrest in a metaphase I-like state (PubMed:33060131). Spermatocytes have defects in both cytokinesis and post-meiotic partitioning (PubMed:33060131).

6239:CELE F44F4.6
gene id: 6239:CELE_F44F4.6
uniprot id: G5ECK8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F26E4.10
gene id: 6239:CELE_F26E4.10
uniprot id: O01326
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family.
messages: Each RNase III domain binds at least one Mg(2+) or Mn(2+) ion.
messages: Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.
messages: Nucleus
messages: Sterility.

6239:CELE B0303.2
gene id: 6239:CELE_B0303.2
uniprot id: P34254
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism (PubMed:24077178).
messages: Suppressed lifespan extension when exposed to nicotinic acid and nicotinamide. Reduced reactive oxygen species levels when exposed to nicotinic acid.

6239:CELE C18E3.2
gene id: 6239:CELE_C18E3.2
uniprot id: O02101
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMARCD family.
messages: Chromosome
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes (Probable). The canonical complex contains a catalytic subunit swsn-4, core subunits swsn-1 and swsn-5, and accessory subunits swsn-3, swsn-6, phf-10, dpff-1, swsn-9 and either ham-3/swsn-2.1 or swsn-2.2 (Probable).
messages: Expression begins at the gastrulation stage (PubMed:23457234). Expressed broadly at L1 larval stage except in the intestine (PubMed:23457234). Expression decreases in the subsequent larval stages and is absent in adults (PubMed:23457234).
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Probably regulates vulva development through the let-60/Ras pathway (PubMed:26739451). Involved in nuclear reassembly after mitosis and recruitment of nuclear envelope protein, mel-28, to the nuclear periphery in the early embryo and in the adult germline (PubMed:26739451). Involved in gonadogenesis (PubMed:26739451, PubMed:24402584).
messages: Nucleus envelope
messages: Some knockouts exhibit maternal-effect embryonic or larval lethality (PubMed:24402584). Germ lines are smaller (PubMed:26739451). RNAi-mediated knockdown reduces brood size (PubMed:26739451). Simultaneous knockouts of ham-3 do not survive beyond the L2 larval stage (PubMed:24402584). Simultaneous RNAi-mediated knockdown of ham-3 at the L1 larval stage causes sterility, while at the L3 larval stage, causes embryonic lethality for the progeny (PubMed:26739451). The sterile animals resulting from simultaneous RNAi-mediated knockdown of ham-3 at the L1 larval stage develop smaller germ lines (PubMed:26739451). Simultaneous RNAi-mediated knockdown of ham-3 also results in vulva protrusion and ectopic expression of egl-17 in cells derived from the vulval precursor cells P5.p and P7.p (PubMed:26739451).
messages: nucleoplasm

6239:CELE C08F8.1
gene id: 6239:CELE_C08F8.1
uniprot id: Q17827
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Has a role in gonadogenesis.
messages: Cytoplasm
messages: Expressed in the distal cell tip of developing embryos.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Worms exhibit defects in distal cell tip migration during gonadogenesis, reduced microtubule growth rate in embryos, and larvae arrest and lethality.

6239:CELE F52H3.2
gene id: 6239:CELE_F52H3.2
uniprot id: Q20680
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

6239:CELE F42H10.7
gene id: 6239:CELE_F42H10.7
uniprot id: P34420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus
messages: Regulates pre-mRNA splicing.

6239:CELE C54C6.2
gene id: 6239:CELE_C54C6.2
uniprot id: Q18817
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE F45F2.7
gene id: 6239:CELE_F45F2.7
uniprot id: Q22976
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE T12D8.6
gene id: 6239:CELE_T12D8.6
uniprot id: Q9XVI9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Arrest at the 1-cell stage embryo due to a cytokinesis defect characterized by a failure to form a contractile ring.
messages: Cytoplasm
messages: Expressed during embryogenesis in seam cells as well as in the dorsal and ventral hypodermal cells where it co-localizes with actin bundles.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles.
messages: cytoskeleton

6239:CELE W03F8.1
gene id: 6239:CELE_W03F8.1
uniprot id: O44572
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the troponin I family.
messages: Expression is detected only in pharyngeal muscle cells from embryos to adults.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
messages: Worms exhibit developmental arrest at gastrulation.

6239:CELE C55B7.5
gene id: 6239:CELE_C55B7.5
uniprot id: Q966M4
names: Subunit
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE W05H5.3
gene id: 6239:CELE_W05H5.3
uniprot id: P91840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

6239:CELE W01G7.1
gene id: 6239:CELE_W01G7.1
uniprot id: G5EDM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SKI family.
messages: Expressed in ganglia in the head and tail and in the anterior pharynx.
messages: May interact with daf-3.
messages: Nucleus
messages: Probable component of transcriptional regulatory complex with SMAD protein daf-3 (PubMed:14681186). Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:14681186). Involved in larvae undergoing cell-cycle arrest during the dauer stage (PubMed:14681186).

6239:CELE F49B2.5
gene id: 6239:CELE_F49B2.5
uniprot id: O45539
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Expressed in vulva, cells around anus and pharyngeal muscles.
messages: May be inhibited by csk-1-mediated phosphorylation at Tyr-500.
messages: May be phosphorylated on Tyr-500 by csk-1.
messages: Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.
messages: RNAi-mediated knockdown causes no obvious effect on embryonic development (PubMed:12527374). Animals have a slight decrease in unc-5 tyrosine phosphorylation (PubMed:16024786).

6239:CELE Y10G11A.3
gene id: 6239:CELE_Y10G11A.3
uniprot id: A0A078BPK5
uniprot id: Q7YTJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6239:CELE C46G7.1
gene id: 6239:CELE_C46G7.1
uniprot id: O02142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

6239:CELE T01G1.3
gene id: 6239:CELE_T01G1.3
uniprot id: G5EFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

6239:CELE Y5H2A.2
gene id: 6239:CELE_Y5H2A.2
uniprot id: Q966A2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F47E1.4
gene id: 6239:CELE_F47E1.4
uniprot id: Q95ZT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C36A4.9
gene id: 6239:CELE_C36A4.9
uniprot id: Q18496
uniprot id: Q65ZB8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y54F10AM.4
gene id: 6239:CELE_Y54F10AM.4
uniprot id: Q9BL02
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Asn-1149 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.
messages: Belongs to the CUT homeobox family.
messages: Nucleus
messages: Probable DNA-binding regulatory protein involved in cell-fate specification.

6239:CELE Y73F8A.1
gene id: 6239:CELE_Y73F8A.1
uniprot id: Q9U1S7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Exclusively expressed in a subset of 3 categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons (PubMed:10517638, PubMed:11553327, PubMed:12411744, PubMed:15563610, PubMed:16943275, PubMed:16481400, PubMed:31264582). Expressed in the male tail (PubMed:26150102, PubMed:28745435).
messages: First expressed during L4 and peaks in the adult male.
messages: Functions as a calcium permeable cation channel (PubMed:15862350). Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location (PubMed:11553327, PubMed:12411744, PubMed:15862350, PubMed:15753033, PubMed:18037411, PubMed:28745435). Acts in the same pathway as lov-1 and atp-2 in response behavior (PubMed:11553327).
messages: Perikaryon
messages: Phosphorylated. CK2 (kin-3 and kin-10) and calcineurin act antagonistically to regulate the phosphorylation state.
messages: The transmembrane domains are sufficient for localization in the cilium. The cytoplasmic tails are necessary for localization in cell bodies and anchoring at the ciliary base. Cytoplasmic tails also regulate sensory function.
messages: Worms exhibit defects in 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location.
messages: axon
messages: cilium
messages: cilium membrane
messages: dendrite

6239:CELE D1007.2
gene id: 6239:CELE_D1007.2
uniprot id: O01873
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y87G2A.4
gene id: 6239:CELE_Y87G2A.4
uniprot id: G5EBS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

6239:CELE C15C8.2
gene id: 6239:CELE_C15C8.2
uniprot id: G5EFL9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:17628356). Forms a heterodimer with ARNT homolog aha-1; binds DNA as heterodimer (PubMed:17628356).
messages: Nucleus
messages: Transcription factor (PubMed:17628356). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT homolog aha-1 (PubMed:17628356). Regulates transcription of target genes, probably acting in complex with aha-1 (PubMed:17628356).

6239:CELE F02D10.5
gene id: 6239:CELE_F02D10.5
uniprot id: G5EGI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F16F9.4
gene id: 6239:CELE_F16F9.4
uniprot id: Q94187
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

6239:CELE C12C8.2
gene id: 6239:CELE_C12C8.2
uniprot id: A5JYW2
uniprot id: O02215
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

6239:CELE F09E5.1
gene id: 6239:CELE_F09E5.1
uniprot id: Q19266
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the anterior and posterior pharyngeal bulbs, the pharyngeal-intestinal valve, vulval cells, and a region at the posterior end of the intestine that corresponds to site of co-assembly of the intestinal-rectal valve and anal sphincter, and depressor muscles. Modest expression apparent in four hypodermal cells that provide cuticle and muscle anchorage in the tail. Strong expression observed in discrete patches and spots in vulval cells and in somatic cells of the spermatheca. Transiently coexpressed and colocalized with par-6 and par-3, asymmetrically in the developing somatic gonad, including the spermathecal precursor cells of L4 larvae.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Expressed throughout development, at highest level in the L1 stage and lowest in L3. Peripheral staining pattern in early embryos. The staining in 1-cell embryos is weak and uniform just after the completion of meiosis, but increases in intensity and becomes concentrated at the anterior periphery during pronuclear migration. The peripheral staining becomes restricted to about 50% embryo length during the pronuclear meeting and pronuclear fusion stage. By early anaphase, the staining extends posteriorly beyond the midline of the zygote and covers about 60% of the total length of embryos. In 2- and 4-cell stages, staining is uniform at the periphery of the AB cell, its daughters and the EMS cell, but peripheral staining in P1 and P2 is restricted to the boundaries with other blastomeres.
messages: Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery.
messages: Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779). Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192). Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982). Phosphorylates serine residues of num-1 (PubMed:11134025). Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113).
messages: Residues 212-224 are capable of binding the PID domain of num-1 isoform a and isoform c.
messages: Worms show defects in embryogenesis. Mutant embryos show defects in their polarity and cleavage patterns which disrupt hatching (PubMed:9716526). RNAi-mediated knockdown causes a complete loss of nlp-29 expression following fungal infection by D.coniospora or physical injury (PubMed:19380113).
messages: cytoskeleton

6239:CELE F23H12.4
gene id: 6239:CELE_F23H12.4
uniprot id: H2L2C4
uniprot id: P08124
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE F33D11.4
gene id: 6239:CELE_F33D11.4
uniprot id: A0A131MAP5
uniprot id: P17487
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Causes abnormal ectopic expression of homeobox protein vab-7 in VB motor neurons (PubMed:17289921). Suppresses the inability to move backward in an unc-4 mutant background (PubMed:17289921, PubMed:22619391). In an unc-4 mutant background, expression of innexin unc-7 in puncta adjacent to VA motor neurons is significantly reduced for posterior neurons, probably as a result of miswiring of gap junctions (PubMed:17289921).
messages: Expressed in VB motor neurons in the ventral nerve cord.
messages: Nucleus
messages: Transcription factor (PubMed:17289921). Plays a role, downstream from homeobox protein unc-4 and Wnt signaling, in specifying synaptic inputs to A-class motor neurons (PubMed:17289921, PubMed:22619391). Involved in patterning of the synaptic outputs of the postmitotic DA class cholinergic motor neurons (PubMed:34388088).

6239:CELE Y39H10A.3
gene id: 6239:CELE_Y39H10A.3
uniprot id: Q965W9
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 346 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Expressed in the intestine and in head and tail neurons including CAN neuron at L1 stage larva. Expressed in the postdeirid neuron, in the developing vulva and in rectal epithelial cells at L2 stage larva. Expressed in lateral hypodermal (seam) cells and the hypodermal syncytium (hyp7) at L3 stage larva.
messages: Heterodimer with lipid phosphatase mtm-6.
messages: May act as a regulatory subunit for mtm-6. In association with phosphatase mtm-6, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969). Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969). Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development probably by controlling Wnt ligand secretion through the regulation of sorting receptor mig-14 trafficking (PubMed:21076391). Involved in the formation of correct synapse number in DA9 motor neurons (PubMed:25479419).
messages: Membrane

6239:CELE T28D9.4
gene id: 6239:CELE_T28D9.4
uniprot id: Q10023
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y71A12B.4
gene id: 6239:CELE_Y71A12B.4
uniprot id: Q9GRV5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54C8.4
gene id: 6239:CELE_F54C8.4
uniprot id: P34442
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

6239:CELE F46B6.8
gene id: 6239:CELE_F46B6.8
uniprot id: Q20449
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

6239:CELE Y11D7A.4
gene id: 6239:CELE_Y11D7A.4
uniprot id: Q9XWR6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Expressed in amphid and phasmid ciliated sensory neurons.
messages: GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons.
messages: No visible phenotype, with seemingly normal ciliary structure, and normal transport and function of IFT proteins such as osm-6.
messages: Perikaryon
messages: cilium axoneme
messages: cilium membrane

6239:CELE T06D8.6
gene id: 6239:CELE_T06D8.6
uniprot id: P53703
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Mitochondrion inner membrane
messages: Probable lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.

6239:CELE T04H1.6
gene id: 6239:CELE_T04H1.6
uniprot id: Q22179
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C34G6.2
gene id: 6239:CELE_C34G6.2
uniprot id: O01497
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y60A3A.13
gene id: 6239:CELE_Y60A3A.13
uniprot id: G5ECI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

6239:CELE C47E8.4
gene id: 6239:CELE_C47E8.4
uniprot id: Q18691
names: Disruption Phenotype
names: Similarity
messages: Belongs to the FAM50 family.
messages: Reduced growth and mobility. Larval lethal.

6239:CELE F18E3.6
gene id: 6239:CELE_F18E3.6
uniprot id: Q19563
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y53F4B.1
gene id: 6239:CELE_Y53F4B.1
uniprot id: Q9NAC7
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE T06D4.4
gene id: 6239:CELE_T06D4.4
uniprot id: O16652
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE T09A5.7
gene id: 6239:CELE_T09A5.7
uniprot id: P45967
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

6239:CELE T13F2.8
gene id: 6239:CELE_T13F2.8
uniprot id: H2L2G6
uniprot id: Q94051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer containing 14-16 monomers per oligomer.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

6239:CELE Y51A2D.15
gene id: 6239:CELE_Y51A2D.15
uniprot id: F3Y5P4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCDC88 family.
messages: Embryonic lethal with few malformed larvae that develop to the L1 stage of larval development.
messages: Expressed in AQR and PQR gas-sensing neurons in hermaphrodites (at protein level).
messages: Expressed in the embryo from late gastrulation onwards (PubMed:31988188). Broadly expressed during embryogenesis with high expression at the presumptive nose during the 1.5-fold stage of embryogenesis (PubMed:27623382). Expressed in AWB sensory neurons in larvae and in PHA/PHB tail neurons at the L1 stage of larval development (PubMed:27623382).
messages: Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI, the phasmid neurons PHA and PHB and the gas sensing neurons AQR, PQR, URX and BAG (PubMed:27623382, PubMed:31988188). Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10 (PubMed:27623382). Plays a more prominent role in regulating dendrite morphogenesis in AQR than in PQR neurons (PubMed:33460640). Regulates localization of hmr-1 to the distal AQR dendrite (PubMed:33460640). During embryonic elongation, required for the anchoring of URX and BAG dendrites to the presumptive nose (PubMed:31988188).
messages: The C-terminal domain is required for localization to the cilium basal body and role in ciliogenesis.
messages: centriole
messages: cilium basal body

6239:CELE ZC412.1
gene id: 6239:CELE_ZC412.1
uniprot id: Q23305
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE Y54E5B.3
gene id: 6239:CELE_Y54E5B.3
uniprot id: Q95Q17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex (By similarity). Interacts with mdt-10 and mdt-21. Interacts with RNA polymerase II.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for germ cell development and gonadal growth.
messages: Nucleus

6239:CELE Y66H1A.2
gene id: 6239:CELE_Y66H1A.2
uniprot id: Q9TYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

6239:CELE Y66D12A.7
gene id: 6239:CELE_Y66D12A.7
uniprot id: Q9BI40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE D2021.4
gene id: 6239:CELE_D2021.4
uniprot id: Q1W0S0
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE C17G1.6
gene id: 6239:CELE_C17G1.6
uniprot id: Q93243
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in hypodermal cells. Not expressed in the seam cells in L1 to L3 larvae, but it is present in seam cells of L4 larvae. Also expressed in attachment points of the cuticle at the anterior end of larvae, in the arcade cells in the mouth, the anterior pharynx, the amphid socket cells, and in the rectal epithelial cells at the posterior end of the larvae (at protein level).
messages: Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:15255192). Required during ecdysis, the opening of the cuticle to allow the worm to escape (PubMed:15539494).
messages: Present in hypodermal cells of the anterior cuticle 4 hours before each molt and is shed in the cuticle after ecdysis.
messages: Secreted
messages: Worms exhibit incomplete ecdysis; at each molt the cuticle fails to open sufficiently at the anterior end and the partially shed cuticle is dragged behind the animal.

6239:CELE Y110A7A.1
gene id: 6239:CELE_Y110A7A.1
uniprot id: Q95Y84
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosomal protein which is recruited to mitotic chromosomes by hcp-3 (CENP-A) and hcp-4 (CENP-C) (PubMed:12080088, PubMed:15767665). Involved in chromosome segregation during mitosis, playing a role in chromosome condensation and in maintaining chromosome morphology, rigidity and orientation during mitosis (PubMed:12080088, PubMed:15767665).
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: RNAi-mediated knockdown results in temperature sensitive embryonic lethality with chromosomes displaying segregation defects with increased anaphase bridges and chromosome lagging.
messages: centromere

6239:CELE F22B5.1
gene id: 6239:CELE_F22B5.1
uniprot id: Q19705
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cytoplasm
messages: Expression is first detected during embryogenesis at the beginning of morphogenesis and continues in a subset of larval tissues and in adult neurons.
messages: GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.
messages: In the embryo, strongly expressed in migrating hypodermal cells. Shortly before the beginning of elongation, expressed in many developing neurons where it persists throughout adulthood. In the larva, highly expressed in migrating hypodermal cells and the uterus. Also expressed in vulva, spermatheca, sheath cells, distal tips cells and proctoderm of the male tail.
messages: Worms exhibit abnormal vulva, gonad and male tail development and disruption in embryonic proliferation. Subcellular defects include a lack of microtubule cytoskeleton and excessive chromosomes in oocyte nuclei. Many embryos show a lethal phenotype arrested at the bean stage just prior to the beginning of morphogenesis.
messages: centrosome

6239:CELE ZK742.1
gene id: 6239:CELE_ZK742.1
uniprot id: Q23089
names: Similarity
messages: Belongs to the exportin family.

6239:CELE F36H5.6
gene id: 6239:CELE_F36H5.6
uniprot id: P91292
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F15A2.6
gene id: 6239:CELE_F15A2.6
uniprot id: Q19469
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Expressed in neurons. Colocalizes with strd-1 along the dorsal nerve cord.
messages: Interacts with strd-1 and nab-1.
messages: Pre-synaptic vesicle and active zone proteins fail to be restricted to the axons of motor and sensory neurons. Synaptic vesicles fail to form tight clusters implying aberrant synaptic organization in addition to defects in neuronal polarity. Overexpression causes mislocalization of vesicle proteins to dendrites.
messages: Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.
messages: Synapse

6239:CELE Y64G10A.7
gene id: 6239:CELE_Y64G10A.7
uniprot id: A0A061AKU0
uniprot id: G5ECL0
uniprot id: G5EFX3
uniprot id: N1NTK8
uniprot id: N1NVB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C50E10.10
gene id: 6239:CELE_C50E10.10
uniprot id: A3QMA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y113G7B.17
gene id: 6239:CELE_Y113G7B.17
uniprot id: Q9U2X0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins (PubMed:21531333, PubMed:24140420, PubMed:27994012, PubMed:28158808). Catalyzes the formation of monomethylarginine and asymmetric dimethylarginine on histones H2A and H4, a specific tag for epigenetic transcriptional activation (PubMed:21531333). Catalyzes asymmetric arginine dimethylation of mitochondrial proteins necessary for mitochondrial oxidative phosphorylation activity and thus aerobic respiration and ATP synthesis, and the mitochondrial stress response (PubMed:27994012). Methylates arginine residues in P-granule components pgl-1 and pgl-3 to promote P-granule degradation by autophagy in somatic cells to ensure exclusive localization of the P-granules in germ cells (PubMed:24140420). Modulates the interaction of P-granule proteins epg-2 and sepa-1 (PubMed:24140420). Methylates arginine residues in daf-16, which blocks ftt-2 binding to daf-16, prevents akt-mediated phosphorylation and allows for daf-16 to translocate to the nucleus (PubMed:21531333). In turn, association with daf-16 therefore allows for the transcriptional activation of daf-16 and regulation of longevity-related genes (PubMed:21531333). Maintains lifespan by modulating daf-16 activity downstream of the daf-2 signaling pathway (PubMed:21531333, PubMed:28158808). Plays a role in heat and oxidative stress resistance (PubMed:21531333, PubMed:28158808). Role in stress resistance and also fat storage may be in association with the daf-2 signaling pathway (PubMed:21531333). Required for normal feeding behavior (PubMed:27994012).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Expressed from embryogenesis (PubMed:24140420). Expressed during larval development and adulthood (PubMed:21531333).
messages: Interacts with daf-16 (PubMed:21531333). Interacts with pgl-1 and pgl-3 (PubMed:24140420). Interacts with alg-1 (PubMed:23516374).
messages: Nucleus
messages: Viable with a slight decrease in egg-laying (PubMed:28158808). Defective arginine methyltransferase activity with reduced asymmetric dimethylation of targets (PubMed:21531333, PubMed:28158808). Reduced asymmetric arginine dimethylation of mitochondrial proteins which results in defective mitochondrial oxidative phosphorylation activity characterized by a reduced oxygen consumption rate during aerobic respiration as compared to wild-type animals, defective electron chain function and increased reactive oxygen species production (PubMed:27994012). This overall leads to reduced ATP synthesis and increased mitochondrial stress with an up-regulation of stress response genes conferring a food avoidance phenotype (PubMed:27994012). Defective symmetric arginine dimethylation of targets in mitochondria (PubMed:27994012). Increased phosphorylation of daf-16, increased binding of daf-16 to ftt-2 and subsequently increased cytoplasmic retention of daf-16 (PubMed:21531333). Reduced lifespan as a result of reduced expression of longevity-related proteins such as sod-3, mtl-7, sip-1 and lys-7 (PubMed:21531333, PubMed:28158808). Increased sensitivity to heat and oxidative stress (PubMed:28158808). Double knockout with prmt-5 results in prolonged larval development, shorter body size, reduced brood size, decreased egg-laying and 30% of eggs fail to hatch (PubMed:28158808). Double knockout also results in reduced asymmetric and symmetric arginine dimethylation of proteins (PubMed:28158808).
messages: Widely expressed in pharyngeal, body wall muscle, intestinal and vulval cells.

6239:CELE F55A11.2
gene id: 6239:CELE_F55A11.2
uniprot id: Q20797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

6239:CELE Y55D5A.3
gene id: 6239:CELE_Y55D5A.3
uniprot id: Q9GUI1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit (PubMed:30301806). Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (By similarity).
messages: Belongs to the acid ceramidase family.
messages: Degrades bioactive fatty acid amides, such as N-palmitoylethanolamine, to ethanolamine and free fatty acids.
messages: Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.
messages: Lysosome
messages: Membrane
messages: N-glycosylated.

6239:CELE K03E6.4
gene id: 6239:CELE_K03E6.4
uniprot id: Q21191
names: Subcellular Location Annotation
messages: cilium basal body

6239:CELE F10G7.2
gene id: 6239:CELE_F10G7.2
uniprot id: Q19328
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

6239:CELE K08E3.2
gene id: 6239:CELE_K08E3.2
uniprot id: Q9XUT1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE W09G12.1
gene id: 6239:CELE_W09G12.1
uniprot id: O45203
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE Y53F4B.39
gene id: 6239:CELE_Y53F4B.39
uniprot id: Q95Q18
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

6239:CELE C15A7.2
gene id: 6239:CELE_C15A7.2
uniprot id: Q18000
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W02B3.7
gene id: 6239:CELE_W02B3.7
uniprot id: Q09343
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T09D3.2
gene id: 6239:CELE_T09D3.2
uniprot id: Q23034
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F44B9.7
gene id: 6239:CELE_F44B9.7
uniprot id: P34428
names: Subunit
messages: Interacts with mdt-28.

6239:CELE ZK858.1
gene id: 6239:CELE_ZK858.1
uniprot id: G5EFL0
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in the hermaphrodite germline. In the germline, forms a complex with gls-1 which directly binds to gld-1 mRNA and prevents its degradation.
messages: Expressed both maternally and zygotically throughout embryonic development and in adult hermaphrodites.
messages: Germline-specific.
messages: High embryonic lethality. Hermaphrodite animals are partially fertile and those that produce sperm and oocytes have reduced brood sizes and display smaller germlines. Hermaphrodite gld-4 and gld-2 double mutants are fully sterile and display either an earlier meiotic arrest than gld-2 single mutant or a failure to commit to meiotic progression and a return to mitosis.
messages: In contrast to other poly(A) RNA polymerases, lacks any RNA-binding domain.
messages: Interacts with gls-1 isoform C.
messages: The gld-4 locus produces a single transcript that is SL-1 trans-spliced.
messages: perinuclear region

6239:CELE Y81G3A.5
gene id: 6239:CELE_Y81G3A.5
uniprot id: Q9XVY1
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE H19M22.3
gene id: 6239:CELE_H19M22.3
uniprot id: O44836
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Expressed at the comma, 1.5-fold and 3-fold embryonic stages in multiple cells including muscle and somatic gonad cells. In L1 larvae, predominantly expressed in specific muscles and somatic gonad cells, in L2 larvae predominantly expressed in muscles cells and in L4 larvae expressed predominantly in the developing spermatheca and more weakly in vulva muscle cells. Expression increases in the hypodermis in dauer stage larvae prior molting to L4 larval stage.
messages: Expressed in spermatheca and spermathecal-uterine valve, weakly in vulva and anal muscles and in two cells in the head (probably RMEV and RMED motor neurons).
messages: Inhibited by human TIMP1 and TIMP2 and the broad MMP inhibitors BB94 (Batimastat) and CT543.
messages: Intron retention.
messages: Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:24957743). Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol (PubMed:20600277, PubMed:24957743).
messages: RNAi-mediated knockdown causes a delay in larval to adult development with reduced motility and feeding (PubMed:20600277). Also reduces fecundity in adults (PubMed:20600277). Larvae have molting defects characterized by incomplete cuticle shedding leaving a constriction ring in the larvae anterior part (PubMed:20600277). Reduces survival upon Gram-negative bacterium P.luminescense infection or heat stress (PubMed:20600277, PubMed:24957743). Production of extra- and intra-cellular reactive oxygen species (ROS) and protein oxidation are increased whereas vit-6 transcription and dehydroergosterol (DHE) uptake are reduced (PubMed:24957743). Moreover, causes constitutive daf-16 nuclear localization (PubMed:24957743). Simultaneous RNAi-mediated knockdown of vit-6, rme-2, daf-16 or daf-16 coactivators sir2.1, ftt-2 and par-2 restores normal thermotolerance (PubMed:24957743). RNAi-mediated knockdown in a daf-9 or daf-12 mutant background reduces survival further upon heat stress.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

6239:CELE C09G9.4
gene id: 6239:CELE_C09G9.4
uniprot id: Q17874
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE ZC581.2
gene id: 6239:CELE_ZC581.2
uniprot id: O01773
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C53C9.3
gene id: 6239:CELE_C53C9.3
uniprot id: H2KZE7
uniprot id: Q7JPF0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F43C1.7
gene id: 6239:CELE_F43C1.7
uniprot id: Q6A574
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

6239:CELE T27D12.1
gene id: 6239:CELE_T27D12.1
uniprot id: D1MN75
uniprot id: Q22832
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C32F10.5
gene id: 6239:CELE_C32F10.5
uniprot id: O01683
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). In embryos, may function redundantly with hmg-4 to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114). In the germline, acts non-redundantly with hmg-4 to play a role in oocyte development (PubMed:30336114).
messages: Component of the FACT complex, a stable heterodimer of hmg-3 and spt-16 (Probable). The FACT complex may also include hmg-4 instead of hmg-3 (Probable).
messages: Expressed in the germline.
messages: Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage, but, in contrast to hmg-4, expression begins to decrease in somatic cells from the 8E stage until the 2-fold stage (PubMed:30336114). However, expression in the germline persists throughout the larval and adult stages (PubMed:30336114).
messages: Nucleus
messages: RNAi-mediated knockdown at the L4 larval stage results in less than 10% embryonic lethality in offspring and surviving adults are sterile (PubMed:30336114). Double RNAi-mediated knockdown with hmg-4 at the L4 larval stage results in 60% embryonic lethality in offspring (PubMed:30336114). Double RNAi-mediated knockdown with hmg-4 in embryos results in defective cell cycle initiation, duration and completion and in failed development of the anterior pharynx (PubMed:30336114).

6239:CELE C37H5.2
gene id: 6239:CELE_C37H5.2
uniprot id: P91143
names: Similarity
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

6239:CELE K05B2.5
gene id: 6239:CELE_K05B2.5
uniprot id: H2L0E6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C04G2.6
gene id: 6239:CELE_C04G2.6
uniprot id: Q17632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex.
messages: Nucleus
messages: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Has both 3'-5' exonuclease and endonuclease activities (By similarity). Involved in regulation of antisense ribosomal siRNA production (PubMed:34365510).
messages: Ubiquitously expressed.
messages: nucleoplasm

6239:CELE F54E12.3
gene id: 6239:CELE_F54E12.3
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y37B11A.2
gene id: 6239:CELE_Y37B11A.2
uniprot id: A0A0K3AUS7
uniprot id: A0A0K3AX87
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE F54C8.2
gene id: 6239:CELE_F54C8.2
uniprot id: P34440
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Cleaved at the onset of meiotic anaphase I, likely by separase sep-1.
messages: Expressed in oocytes at the late pachytene/diplotene stage and during the subsequent meiotic stages (PubMed:16273096, PubMed:25919583). Expressed in polar bodies (PubMed:25919583). Expressed at low levels in embryos (PubMed:16273096, PubMed:25919583).
messages: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, cpar-1 and H4 assembled in one cpar-1-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.
messages: Nucleus
messages: Present at much lower (<5%) level than hcp-3 (at protein level).

6239:CELE Y51H7C.5
gene id: 6239:CELE_Y51H7C.5
uniprot id: E0DBL0
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

6239:CELE M04G12.1
gene id: 6239:CELE_M04G12.1
uniprot id: P92004
uniprot id: Q9XVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

6239:CELE C11D2.7
gene id: 6239:CELE_C11D2.7
uniprot id: Q8MXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

6239:CELE Y47H10A.3
gene id: 6239:CELE_Y47H10A.3
uniprot id: Q9U2B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE W02A2.1
gene id: 6239:CELE_W02A2.1
uniprot id: G5EGA5
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Can function as a Delta(12)/Delta(15) bifunctional desaturase and behaves as a nu +3' desaturase. Introduces a double bond in the fatty acid chain three carbons away from an existing double bond to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a number of substrates like oleoyl-CoA ((9Z)-octadecenoyl-CoA, 18:1n-9), palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA, 16:1n-7), and gamma-linolenoyl-CoA ((6Z,9Z,12Z)-octadecatrienoyl-CoA, 18:3n-6), to generate linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, 18:2n-6), (9Z,12Z)-hexadecadienoyl-CoA (16:2n-4) and (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA (18:4n-3) respectively (PubMed:10775428, PubMed:11972048, PubMed:22041902, PubMed:26806391). Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (Probable).
messages: HPO-19 and T05H4.4 are cytochrome b5 reductases required for PUFA desaturation in Caenorhabditis elegans. HPO-19 knockdown or mutation alters FAT-2 desaturase activity. Although FAT-2 lacks a cytochrome b5 domain, its N-terminal contains a DUF3474 domain that may possess some oxidoreductase activity for electron transfer, obviating the need for an extra cytochrome b5 enzyme, but still requiring cytochrome b5 reductase HPO-19/T05H4.4 to become activated.
messages: Membrane
messages: The fat-2(wa17) mutant leads to high levels of C18:1n-9 and low levels of PUFAs.

6239:CELE Y48E1C.2
gene id: 6239:CELE_Y48E1C.2
uniprot id: O62483
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

6239:CELE C18A3.1
gene id: 6239:CELE_C18A3.1
uniprot id: Q09956
names: Function
names: Similarity
messages: Belongs to the MT-A70-like family.
messages: Methylates DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:25936839). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance (PubMed:25936839).

6239:CELE B0205.7
gene id: 6239:CELE_B0205.7
uniprot id: P18334
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.
messages: Expressed in a subset of the adult male sensory neurons: CEM head neurons, ray RnB neurons, and hook HOB tail neurons.
messages: Perikaryon
messages: Tetramer of two alpha and two beta chains.
messages: axon
messages: cilium
messages: dendrite

6239:CELE C54H2.5
gene id: 6239:CELE_C54H2.5
uniprot id: Q18864
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of the yolk proteins from intestinal cells by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117). Required for the endoplasmic reticulum export of the yolk protein vit-2, which is synthesized as a lipoprotein complex, from intestinal cells (PubMed:29643117). Involved in endoplasmic reticulum exit sites (ERES) organization (PubMed:29643117).
messages: Endoplasmic reticulum membrane
messages: High rate of embryonic and larval lethality (PubMed:29643117). Some mutants reach adulthood but display severe accumulation of vit-2 in large granule-like structures in intestinal cells (PubMed:29643117).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

6239:CELE C35A5.3
gene id: 6239:CELE_C35A5.3
uniprot id: Q18472
names: Subcellular Location Annotation
messages: Membrane

6239:CELE D2005.2
gene id: 6239:CELE_D2005.2
uniprot id: Q93409
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Expressed in the ALA neuron in L4 stage larvae.
messages: May be processed by convertase egl-3.
messages: Neuropeptide-like protein (PubMed:30229400). Plays a role in behaviors associated with a sleep-like state induced by stress (SIS), acting in concert with the FARP (FMRFamide related) peptides, flp-13 and flp-24 (PubMed:27546573).
messages: Secreted

6239:CELE K12D12.1
gene id: 6239:CELE_K12D12.1
uniprot id: Q23670
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Chromosome
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes (PubMed:20116245, PubMed:23684975, PubMed:27707787). Required for centromere resolution during mitosis (PubMed:18202360). Required for chromosome segregation in anaphase of meiosis I during spermatogenesis (PubMed:27707787). Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions (PubMed:23684975). Promotes DNA break formation upon zygotic genome activation in the Z2 and Z3 primordial germ cells in L1 larvae, thereby activating a checkpoint response (PubMed:26073019). Essential for embryogenesis (PubMed:18202360).
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Expressed in the hermaphrodite and male germline.
messages: Homodimer (By similarity). Interacts with nmad-1; the interaction is required for localization of top-2 to DNA (PubMed:31283754). Interacts with gcna-1; this interaction allows the resolution of topoisomerase 2 DNA-protein cross-links (PubMed:31839538).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:18202360). Disrupts proper hcp-3 localization on mitotic chromosomes indicating unresolved kinetochores and inhibits centromere resolution (PubMed:18202360). Causes a chromosome segregation defect during the first embryonic mitotic divisions without affecting cytokinesis (PubMed:20116245, PubMed:27707787, PubMed:23684975). Leads to increased localization of the condensin component capg-1 to the spindle midzone and the midbody and to chromatin bridges with enriched levels of capg-1 (PubMed:23684975). Increased levels of phosphorylated air-2 at the spindle midzone, indicating activation of the abscission checkpoint (PubMed:23684975). Leads to cleavage furrow regression and failed cytokinesis during the second embryonic division (PubMed:23684975). Results in lack of rad-51 foci formation which are indicative for DNA damage in Z2/Z3 primordial germ cells and leads to premature cell-cycle reentry of the Z2/Z3 cells in L1 stage larvae (PubMed:26073019).
messages: nucleoplasm
messages: spindle

6239:CELE F56F4.2
gene id: 6239:CELE_F56F4.2
uniprot id: A8DZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE M28.7
gene id: 6239:CELE_M28.7
uniprot id: O17972
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the nephrocystin-1 family.
messages: Expressed in ciliated sensory neurons of the head (amphid neurons) and the tail in hermaphrodites (phasmid neurons) and males (sensory ray neurons).
messages: Impaired male mating behavior.
messages: Plays a role in the extension of dendrites from phasmid ciliated sensory neurons (PubMed:34115759). May be necessary for initial assembly of the cilium.

6239:CELE ZC404.9
gene id: 6239:CELE_ZC404.9
uniprot id: Q23290
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

6239:CELE Y116F11B.1
gene id: 6239:CELE_Y116F11B.1
uniprot id: Q9NEK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T23D8.3
gene id: 6239:CELE_T23D8.3
uniprot id: O02327
names: Similarity
messages: Belongs to the LTV1 family.

6239:CELE K08A8.2
gene id: 6239:CELE_K08A8.2
uniprot id: Q21305
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals arrest at the first larval stage of development with an unattached pharynx (PubMed:26153233). Able to form neurons, but with defective terminal differentiation of both AWC and AWB olfactory neurons, OLL and IL1 sensory glutamatergic neurons and cholinergic neurons including IL2, URA and URB (PubMed:26153233, PubMed:26341465). RNAi-mediated knockdown results in failed transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron (PubMed:22493276).
messages: Expressed in AWC and AWB olfactory neurons throughout life (PubMed:26153233, PubMed:26341465). Also expressed in the IL1, IL2, URA, URB and OLL sensory neurons, the AIM, AIN, AVK, RIH interneurons, and the motor neuron class RME (PubMed:26153233).
messages: Interacts with egl-27 and ceh-6 (PubMed:22493276). Interacts with ceh-36 and lim-4 (PubMed:26341465). Interacts with wdr-5.1 (PubMed:25124442).
messages: Limited expression during embryogenesis with expression in only a subset of neuroblasts. Expressed in neuronal progenitor cells late in nervous system development and in some non-neural progenitor cells. Expressed broadly during larval development stages.
messages: Nucleus
messages: Probable transcription factor that regulates the lineage progression of embryonic blast cells and controls the postmitotic specification and differentiation of neurons (PubMed:26153233, PubMed:26341465). Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor ceh-36 to specify AWC neurons and with the LIM homeodomain factor lim-4 to suppress AWC terminal differentiation and promote AWB neuron differentiation (PubMed:26341465). Plays a role in the terminal differentiation of glutamatergic and cholinergic neurons (PubMed:26153233). Required for natural reprogramming events and in particular for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development (PubMed:22493276).

6239:CELE Y47D3A.11
gene id: 6239:CELE_Y47D3A.11
uniprot id: Q9U2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE Y105E8A.22
gene id: 6239:CELE_Y105E8A.22
uniprot id: Q8WQA4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Expressed in the secretory system, hypodermis, vulva, pharyngeal muscle, rectal gland, tubular rectal epithelium cells, and tubular neuronal support cells in the head and tail.
messages: May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows.
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Membrane
messages: Monomer.
messages: The N-terminal part (1-55) is necessary and sufficient for translocation from the cytosol to the membrane.
messages: The structure contains a calcium molecule but it is unclear if this is an artifact of the crystallization process or if it has a physiological role in the activity regulation/formation of the channel.

6239:CELE W07A12.7
gene id: 6239:CELE_W07A12.7
uniprot id: Q9XVW1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Expressed in intestine, some sensory neurons in the head, body wall muscles and socket cells.
messages: Impaired acute acceleration of locomotion speed upon rapid increase in oxygen levels (from 0% to 5-20% oxygen). In double mutants for both rhy-1 and hif-1, normal increase in locomotion speed is restored.
messages: In L4 stage, expressed in vulva, ventral nerve cord, tail and at higher levels in hypodermis.
messages: Induced by hypoxia.
messages: Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1-independent manner (PubMed:16980385). Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis (PubMed:20011506, PubMed:20865124). Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation (PubMed:22405203). Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis (PubMed:16980385).

6239:CELE T09A12.5
gene id: 6239:CELE_T09A12.5
uniprot id: Q8MXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane

6239:CELE Y87G2A.17
gene id: 6239:CELE_Y87G2A.17
uniprot id: Q7YWN4
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in PQR, but not AQR, Q neuroblast descendents.
messages: Functions downstream of migratory protein mig-13 and may play a role in the control of Q neuroblast migration during larval development.
messages: Interacts with abl-1.

6239:CELE C17C3.3
gene id: 6239:CELE_C17C3.3
uniprot id: Q18061
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE R08E3.4
gene id: 6239:CELE_R08E3.4
uniprot id: H2L008
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Expressed from embryos to adults (PubMed:20026024). First expressed in somatic gonadal precursor cells during embryogenesis (PubMed:20026024). In the L2 larval stage of development, expressed in Z1.pa and Z4.ap distal tip cells and their descendants (PubMed:20026024).
messages: Expressed in the somatic gonad, hypodermis and cells in the head and tail (PubMed:20026024). Expressed in amphid and phasmid sheath glia, amphid and phasmid socket glia, and in neurons in the head (PubMed:22298710).
messages: Nucleus
messages: Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons (PubMed:22298710). Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology (PubMed:20026024).
messages: RNAi-mediated knockdown does not cause defects in somatic gonad development (PubMed:20026024). RNAi-mediated knockdown in a ehn-3 rd2 mutant background enhances the defects in gonadal development in the ehn-3 single mutant (PubMed:20026024).

6239:CELE E02H4.3
gene id: 6239:CELE_E02H4.3
uniprot id: G5EDB2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
messages: Cytoplasm
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in body wall, vulval and anal depressor muscles.
messages: Nucleus
messages: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor neurons. Negative regulation of p38 MAPK signaling may in turn modulate the trafficking of the muscle specific receptor eva-1 to the lysosome, to ensure proper display of the eva-1 receptor on the plasma membrane of muscle cells and allow for muscle arm extension towards guidance cues.
messages: Viable, but sterile. Defective extension of body wall muscle connections or arms towards the ventral nerve cord. Reduced expression of the late endosome marker rab-7, and the eva-1 and unc-40 receptors, which are expressed in muscles, and impaired recruitment of madd-4 to the muscle membrane. Double knockout with cup-5 results in increased expression of the eva-1 receptor and rab-7 positive endosomes. Double knockout with eva-1, gex-2, madd-2, madd-4, mkk-4, unc-15, unc-60, unc-93 or unc-98 results in severe muscle arm extension defects as compared to the single knockouts. Double knockout with proteins involved in the p38 MAPK signaling pathway including cebp-1, mak-2, pmk-3 or sek-3 suppress the muscle arm extension defects and eva-1 expression defects in the madd-3 single knockout. Double knockout with dlk-1 also suppresses the eva-1 expression defect, but does not suppress the muscle arm extension defects in the madd-3 single knockout. Double knockout with cebp-1, mak-2 or pmk-3 restores the defect in the recruitment of madd-4 to the muscle membrane in the madd-3 single knockout. Furthermore, double knockout with pmk-3 restores the reduced rab-7 expression level defect in the madd-3 single knockout. Double knockout with unc-54 results in lethality. Triple knockout with unc-54, and either cebp-1, dlk-1, mak-2, pmk-3 or sek-3 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant.

6239:CELE F22A3.5
gene id: 6239:CELE_F22A3.5
uniprot id: Q45EK2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TALE/PBX homeobox family.
messages: Expressed in the intestine at the L4 larval stage and persists into adulthood (PubMed:30956009, PubMed:31675356). Expressed in sensory AWC neurons, pharyngeal muscle cells pm6, and intestine, in the adult (PubMed:30956009, PubMed:31675356).
messages: Forms a heterodimer with homeobox unc-62 (PubMed:30956009, PubMed:31675356). Interacts with pqm-1 (PubMed:30956009).
messages: Nucleus
messages: Probable transcription regulator which binds to DNA, repressing genes involved in longevity and stress, while activating genes involved in reproduction, such as the vitellogenins (PubMed:30956009, PubMed:31675356). Associates with homeobox unc-62 to regulate gene expression, including repression of genes involved in innate immunity (PubMed:30956009, PubMed:31675356). Required for intestinal expression of vitellogenin genes (PubMed:30956009, PubMed:31675356). Negatively modulates longevity, probably independently of effects on vitellogenesis (PubMed:30956009). Involved in lipid homeostasis, contributing to the reallocation of intestinal lipids to the germline and to the formation of the cuticle (PubMed:30956009, PubMed:31675356). Associates with transcriptional regulator pqm-1 at the daf-16 associated element within the promoters of stress-responsive genes to regulate expression (PubMed:30956009).
messages: RNAi mediated knockdown targeted to the intestine represses expression of vitellogenin genes.

6239:CELE F44B9.5
gene id: 6239:CELE_F44B9.5
uniprot id: P34426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet

6239:CELE T09B9.5
gene id: 6239:CELE_T09B9.5
uniprot id: Q09351
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W03F8.4
gene id: 6239:CELE_W03F8.4
uniprot id: O44566
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

6239:CELE ZC168.1
gene id: 6239:CELE_ZC168.1
uniprot id: G5ECW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE F16B4.1
gene id: 6239:CELE_F16B4.1
uniprot id: O61203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C04F1.3
gene id: 6239:CELE_C04F1.3
uniprot id: G5EC36
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in gonadal sheath cells, URA motoneurons, and 10 additional cells near the isthmus and terminal bulb of the pharynx (PubMed:19116151). Expressed in the ALA and BDU cells (PubMed:19116151).
messages: Interacts (via LID domain) with ceh-14 (via LIM zinc-binding domains 1 and 2).
messages: Nucleus
messages: Probable DNA-binding transcriptional activator.

6239:CELE F44E2.7
gene id: 6239:CELE_F44E2.7
uniprot id: P34437
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE M01A8.1
gene id: 6239:CELE_M01A8.1
uniprot id: P34530
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C09H6.1
gene id: 6239:CELE_C09H6.1
uniprot id: O17582
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in neurons.
messages: Loss of function results in a suppression of sel-12 phenotypes, possibly by up-regulating hop-1 expression.
messages: Nucleus
messages: Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12668626, PubMed:24670762). Might play a role in the oxidative stress response (PubMed:24670762).
messages: RNAi-mediated knockdown results in reduced survival upon paraquat treatment to induce oxidative stress.
messages: Up-regulated by oxidative stress.

6239:CELE F56A12.1
gene id: 6239:CELE_F56A12.1
uniprot id: O17894
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expressed in muscles and neurons from embryogenesis to adulthood (PubMed:15282156, PubMed:27855782). First expressed post-fertilization, then accumulates in anterior cells of the embryo that give rise to neuronal and mesodermal tissues and body wall muscle cells, where expression persists and increases (PubMed:15282156). Also expressed in posterior nuclei post-fertilization (PubMed:15282156). At the 2-fold stage of embryogenesis, expression is restricted to fewer cells (PubMed:15282156).
messages: Nucleus
messages: Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons (PubMed:2361334, PubMed:15282156). Specifically, plays a role in the terminal differentiation of RID peptidergic neurons (PubMed:27855782). Also required for CAN neuron axon guidance (PubMed:15282156).
messages: RNAi-mediated knockdown results in 60% larval lethality (PubMed:15282156). Surviving animals display uncoordinated locomotion, withered tail morphology, and defects in both CAN neuronal cell migration and axon guidance (PubMed:15282156).

6239:CELE C14C11.3
gene id: 6239:CELE_C14C11.3
uniprot id: G5EFL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6239:CELE F09A5.1
gene id: 6239:CELE_F09A5.1
uniprot id: Q19235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE K04E7.3
gene id: 6239:CELE_K04E7.3
uniprot id: P55114
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C28H8.6
gene id: 6239:CELE_C28H8.6
uniprot id: Q09476
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Expressed in adult animals.
messages: Isoform a: Expressed in all 95 body wall muscle cells as well as in the pharyngeal muscle cells (at protein level). Isoform c: Expressed in the body wall muscle cells and in the pharyngeal muscle cells.
messages: LIM zinc-binding domains 1-4 are sufficient for the localization to dense bodies, adhesion plaques and M lines in body wall muscles.
messages: M line
messages: RNAi-mediated knockdown leads to developmental arrest at larval stage L1.
messages: Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping (PubMed:21633109). Together with lin-8, might be required for myofilament organization in the body wall muscles (PubMed:21633109).
messages: adherens junction
messages: podosome

6239:CELE K04C2.2
gene id: 6239:CELE_K04C2.2
uniprot id: Q21210
names: Similarity
messages: Belongs to the MYBBP1A family.

6239:CELE K11D2.3
gene id: 6239:CELE_K11D2.3
uniprot id: P35602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma- and beta'-type subunits), a medium adaptin (mu-type subunit AP47) and a small adaptin (sigma-type subunit AP19) (By similarity). Interacts (via N-terminus) with kvs-4 (PubMed:26762178).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation (PubMed:8288128). Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9 (PubMed:26762178).
messages: Expressed in the cholinergic motor neuron DA9.
messages: Golgi apparatus
messages: clathrin-coated vesicle membrane
messages: dendrite

6239:CELE T16H5.1
gene id: 6239:CELE_T16H5.1
uniprot id: O61715
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expression begins about halfway through embryogenesis. Expressed at higher level in late embryos and in L1 larvae, and fades thereafter. In adults, a weak expression is maintained in several neurons, including ASH but not AWC.
messages: Specifically expressed in sensory neurons and interneurons in the head and tail. Expressed in neurons AWC, ASH, AFD, ASI, ADL, ASK, BAG, AWB, and ADF (head sensory neurons); ADA, AIZ, RIC, AIY, and AIM (head interneurons); PHA and PHB (tail sensory neurons); and PVC and PVQ (tail interneurons).
messages: Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling. Required for the left and right AWC olfactory neurons to establish asymmetric patterns of gene expression during embryogenesis. Acts autonomously.
messages: gap junction

6239:CELE B0416.6
gene id: 6239:CELE_B0416.6
uniprot id: Q11068
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Expressed throughout development.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans (By similarity).
messages: The cofactor is mostly bound to the substrate.
messages: perinuclear region

6239:CELE R04A9.7
gene id: 6239:CELE_R04A9.7
uniprot id: Q21694
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE ZC404.11
gene id: 6239:CELE_ZC404.11
uniprot id: Q23293
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F09F7.4
gene id: 6239:CELE_F09F7.4
uniprot id: Q19278
uniprot id: Q8MNT7
names: Function
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

6239:CELE Y71F9AM.4
gene id: 6239:CELE_Y71F9AM.4
uniprot id: Q6AW08
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

6239:CELE R03G5.5
gene id: 6239:CELE_R03G5.5
uniprot id: A8WFK6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE C04F5.5
gene id: 6239:CELE_C04F5.5
uniprot id: Q7KNQ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K01C8.6
gene id: 6239:CELE_K01C8.6
uniprot id: Q21083
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

6239:CELE F40D4.8
gene id: 6239:CELE_F40D4.8
uniprot id: Q9XV24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F22F1.1
gene id: 6239:CELE_F22F1.1
uniprot id: Q19743
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

6239:CELE T19D12.5
gene id: 6239:CELE_T19D12.5
uniprot id: Q22573
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE K11H3.7
gene id: 6239:CELE_K11H3.7
uniprot id: Q7YWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE ZK20.3
gene id: 6239:CELE_ZK20.3
uniprot id: Q23451
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

6239:CELE C53D5.6
gene id: 6239:CELE_C53D5.6
uniprot id: Q9N5V3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE D2013.9
gene id: 6239:CELE_D2013.9
uniprot id: Q09512
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (By similarity). Lacks tyrosine ligase activity in vitro (By similarity). Lacks glutamylation activity in vitro (By similarity).
messages: Belongs to the tubulin--tyrosine ligase family.
messages: RNAi-mediated knockdown at the L1 larval stage causes a reduction in egg-laying, likely due to a defect in the egg-laying apparatus muscles and in hermaphrodite specific neurons.
messages: Regulates microtubule dynamics in uterine muscle cells.

6239:CELE F23B2.12
gene id: 6239:CELE_F23B2.12
uniprot id: G5EFJ8
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE C24G6.3
gene id: 6239:CELE_C24G6.3
uniprot id: O76384
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

6239:CELE T05B4.2
gene id: 6239:CELE_T05B4.2
uniprot id: O16425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE M04B2.2
gene id: 6239:CELE_M04B2.2
uniprot id: Q21503
names: Similarity
messages: Belongs to the methyltransferase superfamily.

6239:CELE Y105E8A.17
gene id: 6239:CELE_Y105E8A.17
uniprot id: A8XQE0
uniprot id: Q8WQA7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K01D12.6
gene id: 6239:CELE_K01D12.6
uniprot id: Q21096
names: Similarity
messages: Belongs to the mitoguardin family.

6239:CELE F13A7.2
gene id: 6239:CELE_F13A7.2
uniprot id: O17800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C31C9.2
gene id: 6239:CELE_C31C9.2
uniprot id: O17626
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

6239:CELE Y62E10A.13
gene id: 6239:CELE_Y62E10A.13
uniprot id: A0A061ACH4
uniprot id: A0A061ACK7
uniprot id: A0A061ADS3
uniprot id: A0A061AKN1
uniprot id: Q9U1W6
uniprot id: Q9U1W7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

6239:CELE C43F9.8
gene id: 6239:CELE_C43F9.8
uniprot id: Q9U3M2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F20H11.5
gene id: 6239:CELE_F20H11.5
uniprot id: O01739
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Expressed in probable head mesodermal cells and unidentified cells in the head, vulval muscles, hypodermis and the gonad sheath cells in adult hermaphrodites. Also expressed in the seminal vesicle and tail cells in adult males.
messages: Expression in head mesodermal cells detected from L3 stage to adult stages, and in vulval muscles from L4 stage to adult stages.
messages: Homodimer.
messages: Mutant worms have decreased egg-laying capacity at 20 degrees Celsius, and decreased hatching rate and smaller brood size at 25 degrees Celsius. They also show delay in growth to adulthood and an extended life span. Mutant worms have high D-Glu content at both egg and young adult stages and a high L-Trp level at young adult stage but do not show any change in physical appearance.
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs.
messages: extracellular space

6239:CELE ZK353.6
gene id: 6239:CELE_ZK353.6
uniprot id: P34629
names: Cofactor
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase M17 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Expressed in the buccal cavity, pharynx, anterior gut and rectum.
messages: Probably acts as a digestive enzyme.

6239:CELE F20D1.2
gene id: 6239:CELE_F20D1.2
uniprot id: Q93534
names: Subcellular Location Annotation
messages: trans-Golgi network

6239:CELE C17H12.2
gene id: 6239:CELE_C17H12.2
uniprot id: O45086
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C50E10.6
gene id: 6239:CELE_C50E10.6
uniprot id: A3QMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F54E7.3
gene id: 6239:CELE_F54E7.3
uniprot id: Q17353
uniprot id: U4PEM0
uniprot id: U4PM75
uniprot id: U4PRH0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Asymmetrically distributed at the periphery of the zygote and in dividing blastomeres of the germline lineage. Coexpressed with par-6; patchy expression observed at the periphery after completion of meiosis I and in meiosis II. On completion of metaphase II, expression is restricted to the anterior 85% of embryo length; this decreases to 55% in embryos between prophase and telophase of the first mitosis. During the first cleavage, expression is detected in the advancing furrow. Transiently coexpressed and colocalized asymmetrically with par-6 and pkc-3, in the developing somatic gonad, including the spermathecal precursor cells of L4 larvae.
messages: Belongs to the PAR3 family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo (PubMed:8521491, PubMed:9716526). Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces (PubMed:8898226, PubMed:9834192). Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first embryonic division (PubMed:14534135, PubMed:18694560).
messages: Required, together with pkc-3, for the localization of par-6; par-6 is involved in localizing/maintaining par-3 at the cell periphery. Interacts with par-6 and pkc-3 for localization at the periphery of anterior cortex of the embryo.

6239:CELE F40G9.1
gene id: 6239:CELE_F40G9.1
uniprot id: C0Z1Y7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M01A10.3
gene id: 6239:CELE_M01A10.3
uniprot id: P91390
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal (PubMed:23691084, PubMed:24130834). Embryogenesis proceeds more slowly and embryos are osmo-sensitive (PubMed:23691084). Twenty-five percent of embryos exhibit cytokinesis defects (PubMed:24130834). Sixty-five percent of embryos have incorrectly positioned cleavage furrows (PubMed:24130834). Other phenotypes include delayed chromosome alignment at metaphase and disrupted endoplasmic reticulum morphology (PubMed:24130834).
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE C49C3.5
gene id: 6239:CELE_C49C3.5
uniprot id: Q9XUG3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y71G12B.20
gene id: 6239:CELE_Y71G12B.20
uniprot id: Q95XP4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Interacts with plx-2.
messages: Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis (PubMed:10648234, PubMed:12403719, PubMed:17761667). In early embryonic development, required for proper ventral closure of the epidermis (PubMed:12403719). During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays (PubMed:12679110). Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129 (PubMed:15030761). Involved in follower axon guidance (PubMed:25358863, PubMed:28846083). In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring (PubMed:28846083). Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons (PubMed:25358863).
messages: Required for the guidance of axons from neurons, including AIY interneurons, into the nerve ring.
messages: Secreted
messages: Ubiquitously expressed.
messages: Worms have defects both in early embryonic morphogenesis and in postembryonic male tail morphogenesis.

6239:CELE F15A2.4
gene id: 6239:CELE_F15A2.4
uniprot id: Q19474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE W05B10.1
gene id: 6239:CELE_W05B10.1
uniprot id: Q27532
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

6239:CELE Y57G11C.15
gene id: 6239:CELE_Y57G11C.15
uniprot id: G3MU88
uniprot id: O18239
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

6239:CELE EGAP1.3
gene id: 6239:CELE_EGAP1.3
uniprot id: G5EGM1
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the peptidase M10A family.
messages: Cell membrane
messages: Displays very low catalytic activity compared to zmp-2 towards synthetic substrate Mca-Pro-Leu-Gly-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 in vitro.
messages: Expressed in the anchor cell (PubMed:11060231, PubMed:15960981). Expressed in the anchor cell throughout the L3 and the early L4 stage, but not in vulva precursor cells P6.p, P6.px, or P6.pxx (PubMed:11060231). Expression in P6.pxxx cells begins in late-L4 stage. During L4 lethargus, expressed in all four vulE cells, but not in vulF cells (PubMed:11060231). The expression in vulE cells persists in adulthood (PubMed:11060231). In males, expressed in the linker cell (LC) from the early L4 stage until LC death during the L4-to-adult molt (PubMed:19906858).
messages: Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.
messages: No defect in anchor cell invasion. In 7 percent of cdh-3 and zmp-1 double mutants and in 25 percent of cdh-3, him-4 and zmp-1 triple mutants, anchor cell invasion is delayed.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

6239:CELE ZK1321.2
gene id: 6239:CELE_ZK1321.2
uniprot id: Q8I4B0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Shaker sub-subfamily.
messages: Delayed spike repolarization.
messages: Expressed in a variety of interneurons and sensory neurons, as well as body wall muscle.
messages: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.
messages: Membrane

6239:CELE T03D3.1
gene id: 6239:CELE_T03D3.1
uniprot id: O16988
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F02E8.6
gene id: 6239:CELE_F02E8.6
uniprot id: Q19127
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer-constitutive (daf-c) phenotype).
messages: Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons (PubMed:10801441).
messages: Membrane

6239:CELE T12A2.11
gene id: 6239:CELE_T12A2.11
uniprot id: P54127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE B0361.2
gene id: 6239:CELE_B0361.2
uniprot id: Q10946
names: Similarity
messages: Belongs to the CWF19 family.

6239:CELE H06O01.1
gene id: 6239:CELE_H06O01.1
uniprot id: G5ED07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6239:CELE ZC506.1
gene id: 6239:CELE_ZC506.1
uniprot id: Q09641
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE Y73B6BL.19
gene id: 6239:CELE_Y73B6BL.19
uniprot id: Q95XD1
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

6239:CELE F29G9.2
gene id: 6239:CELE_F29G9.2
uniprot id: H2KYP0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC85 family.
messages: Expressed in four-cell stage embryos.
messages: Interacts with pac-1 and jac-1.
messages: Linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions.
messages: Mutants are 97% viable. However, the Rho GTPase-activating protein, pac-1, does not localize to adherens junctions.
messages: adherens junction

6239:CELE F56D1.2
gene id: 6239:CELE_F56D1.2
uniprot id: Q10128
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Component of a heterodimeric receptor complex composed of ilcr-1 and ilcr-2. The receptor complex interacts with actl-1 and ilc-17.1 with the interaction being mediated by ilcr-2.
messages: Expressed in most neurons, and in pharyngeal muscle.
messages: Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.

6239:CELE F02E11.1
gene id: 6239:CELE_F02E11.1
uniprot id: O16574
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE F39H11.5
gene id: 6239:CELE_F39H11.5
uniprot id: P90868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

6239:CELE B0310.3
gene id: 6239:CELE_B0310.3
uniprot id: Q10939
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C18E9.10
gene id: 6239:CELE_C18E9.10
uniprot id: G5EDD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

6239:CELE T25B6.7
gene id: 6239:CELE_T25B6.7
uniprot id: O45813
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Cytoplasm
messages: Expressed in the epidermis throughout development (PubMed:21575913). Also expressed in the seam cells, which are specialized epithelial cells that secrete the cuticle, as well as in the excretory cell, and the amphid and phasmid socket cells (PubMed:21575913).
messages: May interact with STAT family transcription factor sta-2; the interaction is probably direct.
messages: Membrane
messages: Probably mediates sodium-dependent uptake of unknown small molecule(s) (PubMed:21575913). By positively modulating expression, in the epidermis, of antimicrobial peptides such as nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (PubMed:21575913). Role in response to wounding of the epidermis may be facilitated by recruitment of snf-12 to the wound site by microtubule-dependent vesicle trafficking (PubMed:31995031). Functions cell autonomously in the epidermis, in concert with STAT transcription factor sta-2, probably acting at vesicular membranes, downstream of a p38 MAPK/pmk-1 pathway (PubMed:21575913).
messages: Vesicle

6239:CELE T03D3.3
gene id: 6239:CELE_T03D3.3
uniprot id: O16980
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y16B4A.2
gene id: 6239:CELE_Y16B4A.2
uniprot id: K8ESM2
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE C52A10.2
gene id: 6239:CELE_C52A10.2
uniprot id: Q95YC3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE T19C4.4
gene id: 6239:CELE_T19C4.4
uniprot id: Q22572
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE T01G1.1
gene id: 6239:CELE_T01G1.1
uniprot id: G5EGS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Component of a complex at least composed of alpha tubulin and beta tubulin (PubMed:36065637). Within the complex, interacts with the alpha tubulin and beta tubulin dimer (PubMed:36065637).
messages: Microtubule-binding motor protein which has ATPase activity (PubMed:36065637). In complex with alpha and beta tubulins, preferentially binds to the growing microtubule plus-end to stabilize it and detaches following ATP hydrolysis (PubMed:36065637). Negatively regulates axonal length through inhibiting microtubule polymerization at its plus-end (PubMed:36065637).
messages: cytoskeleton

6239:CELE F57B7.1
gene id: 6239:CELE_F57B7.1
uniprot id: Q20929
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in head neurons including the RID neuron and the paired AIY neurons, and in tail neurons including the paired PHA and PHB neurons (PubMed:28094002). Not expressed in AVE and AVA neurons (PubMed:28094002).
messages: G-protein coupled receptor for flp-13 RFamide neuropeptides in vitro (PubMed:28094002). Upon activation by flp-13 RFamide neuropeptides, promotes sleep in response to cellular stress also known as stress-induced sleep (SIS), probably by inhibiting the activity of wake-promoting neurons (PubMed:28094002).
messages: G-protein coupled receptor.

6239:CELE T06D8.7
gene id: 6239:CELE_T06D8.7
uniprot id: Q22252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FUN14 family.
messages: Broadly expressed in somatic tissues (PubMed:31233739). Expressed in the hermaphrodite spermatheca and male gonad (PubMed:31233739). Expressed in spermatids, but not expressed in oocytes (PubMed:31233739).
messages: Mitochondrion outer membrane
messages: Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage.

6239:CELE Y46H3D.5
gene id: 6239:CELE_Y46H3D.5
uniprot id: H2KZT0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C56C10.7
gene id: 6239:CELE_C56C10.7
uniprot id: Q95QQ2
names: Similarity
messages: Belongs to the TRAPPC13 family.

6239:CELE R07E3.3
gene id: 6239:CELE_R07E3.3
uniprot id: Q21808
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expressed in seam cells in three-fold stage embryos and during dauer larvae formation (PubMed:15936343). Not expressed in adults (PubMed:15936343).
messages: Plays a role in alae formation in L1 and dauer stage larvae.
messages: RNAi-mediated knockdown results in disrupted alae formation in L1 and dauer stage larvae with alae often present on only one side of the larvae.

6239:CELE Y73B6BL.31
gene id: 6239:CELE_Y73B6BL.31
uniprot id: Q5W7A3
uniprot id: Q95XC7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C33A11.2
gene id: 6239:CELE_C33A11.2
uniprot id: Q93319
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F15B9.2
gene id: 6239:CELE_F15B9.2
uniprot id: Q19477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE Y57A10C.4
gene id: 6239:CELE_Y57A10C.4
uniprot id: O62489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F01D4.1
gene id: 6239:CELE_F01D4.1
uniprot id: D5MCT5
uniprot id: O17756
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F25E2.1
gene id: 6239:CELE_F25E2.1
uniprot id: Q19779
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F27C1.6
gene id: 6239:CELE_F27C1.6
uniprot id: P91280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

6239:CELE F41E7.3
gene id: 6239:CELE_F41E7.3
uniprot id: Q20275
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE B0024.6
gene id: 6239:CELE_B0024.6
uniprot id: N1NVB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in both ASEL and ASER neurons throughout late embryonic and early larval stages. In adults, expressed asymmetrically in ASE left (ASEL) sensory neuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE Y113G7A.9
gene id: 6239:CELE_Y113G7A.9
uniprot id: G5EFS4
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP.
messages: Expressed in neurons in the ventral cord, the nerve ring and the pharynx.
messages: Expressed in the embryo during all developmental stages.
messages: Nucleus
messages: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro.
messages: Up-regulated by heat schock.

6239:CELE F27C8.1
gene id: 6239:CELE_F27C8.1
uniprot id: Q19834
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K02B2.5
gene id: 6239:CELE_K02B2.5
uniprot id: P52821
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

6239:CELE C54G4.8
gene id: 6239:CELE_C54G4.8
uniprot id: Q18853
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE C55C3.5
gene id: 6239:CELE_C55C3.5
uniprot id: Q18867
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE F56B3.8
gene id: 6239:CELE_F56B3.8
uniprot id: O45110
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

6239:CELE T14A8.1
gene id: 6239:CELE_T14A8.1
uniprot id: Q22472
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ric-3 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in pharyngeal muscles, body wall muscles and in most neurons.
messages: Interacts with the deg-3/des-2 acetylcholine receptor.
messages: Required for maturation and cell surface expression of acetylcholine receptors.

6239:CELE F54D1.3
gene id: 6239:CELE_F54D1.3
uniprot id: G5EFU8
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y43F8B.2
gene id: 6239:CELE_Y43F8B.2
uniprot id: B1V8J2
uniprot id: D9PTN9
uniprot id: D9PTP0
uniprot id: D9PTP1
uniprot id: Q9XWX7
names: Similarity
messages: Belongs to the GSKIP family.

6239:CELE F12B6.3
gene id: 6239:CELE_F12B6.3
uniprot id: X5LQ33
uniprot id: X5LVB0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y66D12A.15
gene id: 6239:CELE_Y66D12A.15
uniprot id: Q95PZ4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

6239:CELE F07C3.7
gene id: 6239:CELE_F07C3.7
uniprot id: Q19151
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T28C6.8
gene id: 6239:CELE_T28C6.8
uniprot id: Q9XVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

6239:CELE B0222.5
gene id: 6239:CELE_B0222.5
uniprot id: Q17457
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R02D1.1
gene id: 6239:CELE_R02D1.1
uniprot id: A0A168H9N2
uniprot id: O17082
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R09G11.2
gene id: 6239:CELE_R09G11.2
uniprot id: Q21878
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor which acts in concert with the insulin/IGF-1-like signaling (IIS) pathway during osmotic stress, perhaps in response to a ligand modified by the sulfotransferase ssu-1.