61622:ZDHHC13
gene id: 61622:ZDHHC13
uniprot id: A0A2K6NZ47
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:HSPB2
gene id: 61622:HSPB2
uniprot id: A0A2K6NAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61622:TRIM27
gene id: 61622:TRIM27
uniprot id: A0A2K6Q3B6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CPEB2
gene id: 61622:CPEB2
uniprot id: A0A2K6NLI0
uniprot id: A0A2K6NLI5
names: Similarity
messages: Belongs to the RRM CPEB family.

61622:CNGA4
gene id: 61622:CNGA4
uniprot id: A0A2K6QZM1
names: Subcellular Location Annotation
messages: Membrane

61622:NCOA7
gene id: 61622:NCOA7
uniprot id: A0A2K6PNG5
names: Similarity
messages: Belongs to the OXR1 family.

61622:MYCL
gene id: 61622:MYCL
uniprot id: A0A2K6QQ74
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

61622:RHBDD3
gene id: 61622:RHBDD3
uniprot id: A0A2K6RU78
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104654807
gene id: 61622:LOC104654807
uniprot id: A0A2K6RMY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:KIF9
gene id: 61622:KIF9
uniprot id: A0A2K6PUV6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:SERPINB11
gene id: 61622:SERPINB11
uniprot id: A0A2K6NC07
uniprot id: A0A2K6NC27
names: Similarity
messages: Belongs to the serpin family.

61622:CD28
gene id: 61622:CD28
uniprot id: A0A2K6RJN9
names: Subcellular Location Annotation
messages: Membrane

61622:KCNH1
gene id: 61622:KCNH1
uniprot id: A0A2K6NFP7
names: Subcellular Location Annotation
messages: Membrane

61622:SPOP
gene id: 61622:SPOP
uniprot id: A0A2K6RLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

61622:SEPTIN1
gene id: 61622:SEPTIN1
uniprot id: A0A2K6QM32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:LOC104673860
gene id: 61622:LOC104673860
uniprot id: A0A2K6Q362
names: Similarity
messages: Belongs to the MHC class II family.

61622:ANO6
gene id: 61622:ANO6
uniprot id: A0A2K6NC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

61622:SGSM2
gene id: 61622:SGSM2
uniprot id: A0A2K6R9C0
uniprot id: A0A2K6R9D3
names: Similarity
messages: Belongs to the RUTBC family.

61622:TIGD6
gene id: 61622:TIGD6
uniprot id: A0A2K6NKK2
names: Subcellular Location Annotation
messages: Nucleus

61622:EPB41
gene id: 61622:EPB41
uniprot id: A0A2K6RGV6
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

61622:EDNRA
gene id: 61622:EDNRA
uniprot id: A0A2K6NU14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

61622:C5H15orf40
gene id: 61622:C5H15orf40
uniprot id: A0A2K6P585
names: Similarity
messages: Belongs to the UPF0235 family.

61622:POLR2K
gene id: 61622:POLR2K
uniprot id: A0A2K6RJT0
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

61622:DLX2
gene id: 61622:DLX2
uniprot id: A0A2K6PLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

61622:TNRC6C
gene id: 61622:TNRC6C
uniprot id: A0A2K6RDU4
names: Similarity
messages: Belongs to the GW182 family.

61622:PPRC1
gene id: 61622:PPRC1
uniprot id: A0A2K6RPW9
names: Subcellular Location Annotation
messages: Nucleus

61622:ETV3L
gene id: 61622:ETV3L
uniprot id: A0A2K6PWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:SORL1
gene id: 61622:SORL1
uniprot id: A0A2K6QD92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

61622:RUNX1T1
gene id: 61622:RUNX1T1
uniprot id: A0A2K6PNV4
names: Similarity
messages: Belongs to the CBFA2T family.

61622:TCN2
gene id: 61622:TCN2
uniprot id: A0A2K6Q814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

61622:DHCR7
gene id: 61622:DHCR7
uniprot id: A0A2K6R7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

61622:GNB4
gene id: 61622:GNB4
uniprot id: A0A2K6R4Z3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

61622:TRIM38
gene id: 61622:TRIM38
uniprot id: A0A2K6P0H7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:C1H3orf70
gene id: 61622:C1H3orf70
uniprot id: A0A2K6RBK1
names: Similarity
messages: Belongs to the UPF0524 family.

61622:LOC104672978
gene id: 61622:LOC104672978
uniprot id: A0A2K6P563
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:TMEM87A
gene id: 61622:TMEM87A
uniprot id: A0A2K6QLD8
names: Subcellular Location Annotation
messages: Membrane

61622:LPXN
gene id: 61622:LPXN
uniprot id: A0A2K6Q887
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

61622:PPM1F
gene id: 61622:PPM1F
uniprot id: A0A2K6RSP0
names: Similarity
messages: Belongs to the PP2C family.

61622:NKAIN3
gene id: 61622:NKAIN3
uniprot id: A0A2K6P5T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

61622:LYRM7
gene id: 61622:LYRM7
uniprot id: A0A2K6Q6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

61622:NDUFV1
gene id: 61622:NDUFV1
uniprot id: A0A2K6QG60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

61622:ECI1
gene id: 61622:ECI1
uniprot id: A0A2K6PSE3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

61622:FN3KRP
gene id: 61622:FN3KRP
uniprot id: A0A2K6RKW6
uniprot id: A0A2K6RKY5
names: Similarity
messages: Belongs to the fructosamine kinase family.

61622:MEPCE
gene id: 61622:MEPCE
uniprot id: A0A2K6PC00
names: Similarity
messages: Belongs to the methyltransferase superfamily.

61622:GRHL3
gene id: 61622:GRHL3
uniprot id: A0A2K6PBK8
names: Subcellular Location Annotation
messages: Nucleus

61622:INPP5D
gene id: 61622:INPP5D
uniprot id: A0A2K6P6R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

61622:PIH1D1
gene id: 61622:PIH1D1
uniprot id: A0A2K6R943
names: Similarity
messages: Belongs to the PIH1 family.

61622:LOC104659463
gene id: 61622:LOC104659463
uniprot id: A0A2K6NIV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ADAMTS4
gene id: 61622:ADAMTS4
uniprot id: A0A2K6P9V1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:ITPA
gene id: 61622:ITPA
uniprot id: A0A2K6PX05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

61622:FOXF1
gene id: 61622:FOXF1
uniprot id: A0A2K6NPR9
names: Subcellular Location Annotation
messages: Nucleus

61622:ORMDL2
gene id: 61622:ORMDL2
uniprot id: A0A2K6QTF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61622:ASB13
gene id: 61622:ASB13
uniprot id: A0A2K6N733
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:KCNAB3
gene id: 61622:KCNAB3
uniprot id: A0A2K6QWA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm
messages: Monomer.

61622:SPSB4
gene id: 61622:SPSB4
uniprot id: A0A2K6RJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

61622:DHRS11
gene id: 61622:DHRS11
uniprot id: A0A2K6QGK6
uniprot id: A0A2K6QGL3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:TMEM178B
gene id: 61622:TMEM178B
uniprot id: A0A2K6QUZ6
names: Similarity
messages: Belongs to the TMEM178 family.

61622:MCPH1
gene id: 61622:MCPH1
uniprot id: A0A2K6NTA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

61622:LBX1
gene id: 61622:LBX1
uniprot id: A0A2K6RNS0
names: Subcellular Location Annotation
messages: Nucleus

61622:EMC2
gene id: 61622:EMC2
uniprot id: A0A2K6QHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

61622:ACOT4
gene id: 61622:ACOT4
uniprot id: A0A2K6Q4J7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:PRKG2
gene id: 61622:PRKG2
uniprot id: A0A2K6PHI6
uniprot id: A0A2K6PHR0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

61622:CRIPT
gene id: 61622:CRIPT
uniprot id: A0A2K6QT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

61622:NSUN3
gene id: 61622:NSUN3
uniprot id: A0A2K6PQY7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61622:FABP1
gene id: 61622:FABP1
uniprot id: A0A2K6QTT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

61622:CXCR3
gene id: 61622:CXCR3
uniprot id: A0A2K6QGN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:ACOX2
gene id: 61622:ACOX2
uniprot id: A0A2K6R963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61622:CTNNA1
gene id: 61622:CTNNA1
uniprot id: A0A2K6N8M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

61622:NKX2-1
gene id: 61622:NKX2-1
uniprot id: A0A2K6NIF7
names: Subcellular Location Annotation
messages: Nucleus

61622:CCND3
gene id: 61622:CCND3
uniprot id: A0A2K6R312
names: Similarity
messages: Belongs to the cyclin family.

61622:LOC104678759
gene id: 61622:LOC104678759
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:HYOU1
gene id: 61622:HYOU1
uniprot id: A0A2K6Q5D0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:BTAF1
gene id: 61622:BTAF1
uniprot id: A0A2K6NLI4
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104680547
gene id: 61622:LOC104680547
uniprot id: A0A2K6QQR0
names: Similarity
messages: Belongs to the SAPAP family.

61622:HMOX1
gene id: 61622:HMOX1
uniprot id: A0A2K6R7E8
names: Similarity
messages: Belongs to the heme oxygenase family.

61622:TMPRSS13
gene id: 61622:TMPRSS13
uniprot id: A0A2K6RVT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TBC1D31
gene id: 61622:TBC1D31
uniprot id: A0A2K6NBK9
uniprot id: A0A2K6NBM0
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

61622:MLF1
gene id: 61622:MLF1
uniprot id: A0A2K6N7C9
uniprot id: A0A2K6N7D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

61622:UBE3D
gene id: 61622:UBE3D
uniprot id: A0A2K6RQP5
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

61622:KEG34 p08
gene id: 61622:KEG34_p08
uniprot id: Q15GN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

61622:ZDHHC9
gene id: 61622:ZDHHC9
uniprot id: A0A2K6R2A4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:TMEM19
gene id: 61622:TMEM19
uniprot id: A0A2K6NK65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

61622:LOC104675640
gene id: 61622:LOC104675640
uniprot id: A0A2K6QRN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

61622:CWC25
gene id: 61622:CWC25
uniprot id: A0A2K6QV10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

61622:UIMC1
gene id: 61622:UIMC1
uniprot id: A0A2K6PCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

61622:LOC104673767
gene id: 61622:LOC104673767
uniprot id: A0A2K6NXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

61622:SNCG
gene id: 61622:SNCG
uniprot id: A0A2K6NMQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.
messages: spindle

61622:TAZ
gene id: 61622:TAZ
uniprot id: A0A2K6QI08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

61622:NPM3
gene id: 61622:NPM3
uniprot id: A0A2K6P3J8
names: Similarity
messages: Belongs to the nucleoplasmin family.

61622:MAB21L2
gene id: 61622:MAB21L2
uniprot id: A0A2K6NAJ7
names: Similarity
messages: Belongs to the mab-21 family.

61622:ABCA6
gene id: 61622:ABCA6
uniprot id: A0A2K6NHE2
names: Subcellular Location Annotation
messages: Membrane

61622:NUDT2
gene id: 61622:NUDT2
uniprot id: A0A2K6NKL5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61622:SIDT1
gene id: 61622:SIDT1
uniprot id: A0A2K6R5P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

61622:KCNH4
gene id: 61622:KCNH4
uniprot id: A0A2K6RG24
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

61622:CARTPT
gene id: 61622:CARTPT
uniprot id: A0A2K6R353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

61622:AURKC
gene id: 61622:AURKC
uniprot id: A0A2K6QD98
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

61622:RSAD1
gene id: 61622:RSAD1
uniprot id: A0A2K6NVW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

61622:EIPR1
gene id: 61622:EIPR1
uniprot id: A0A2K6Q6W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

61622:SET
gene id: 61622:SET
uniprot id: A0A2K6REC5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:CASP6
gene id: 61622:CASP6
uniprot id: A0A2K6NUD1
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:TLE3
gene id: 61622:TLE3
uniprot id: A0A2K6Q9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

61622:UBE2D1
gene id: 61622:UBE2D1
uniprot id: A0A2K6QRW1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:IPO11
gene id: 61622:IPO11
uniprot id: A0A2K6QXU1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:UTP25
gene id: 61622:UTP25
uniprot id: A0A2K6RX08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

61622:IDH3B
gene id: 61622:IDH3B
uniprot id: A0A2K6NQG2
uniprot id: A0A2K6NQG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:PAX3
gene id: 61622:PAX3
uniprot id: A0A2K6N9H4
uniprot id: A0A2K6N9H5
uniprot id: A0A2K6N9I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61622:GNPDA1
gene id: 61622:GNPDA1
uniprot id: A0A2K6QMD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

61622:ACTR10
gene id: 61622:ACTR10
uniprot id: A0A2K6NX04
names: Similarity
messages: Belongs to the actin family.

61622:TM9SF3
gene id: 61622:TM9SF3
uniprot id: A0A2K6QMN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61622:EME1
gene id: 61622:EME1
uniprot id: A0A2K6RWQ2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

61622:MMP2
gene id: 61622:MMP2
uniprot id: A0A2K6QKH8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

61622:VCL
gene id: 61622:VCL
uniprot id: A0A2K6PTY9
uniprot id: A0A2K6PU01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

61622:SLC34A2
gene id: 61622:SLC34A2
uniprot id: A0A2K6PBH2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

61622:GALNT5
gene id: 61622:GALNT5
uniprot id: A0A2K6NY26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:SH3RF1
gene id: 61622:SH3RF1
uniprot id: A0A2K6NIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

61622:SS18
gene id: 61622:SS18
uniprot id: A0A2K6REQ1
uniprot id: A0A2K6REU3
names: Similarity
messages: Belongs to the SS18 family.

61622:THAP10
gene id: 61622:THAP10
uniprot id: A0A2K6QGJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

61622:SHOX2
gene id: 61622:SHOX2
uniprot id: A0A2K6PP43
names: Subcellular Location Annotation
messages: Nucleus

61622:IRF2BP1
gene id: 61622:IRF2BP1
uniprot id: A0A2K6NPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

61622:CLDN11
gene id: 61622:CLDN11
uniprot id: A0A2K6P1G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:HOXA9
gene id: 61622:HOXA9
uniprot id: A0A2K6NSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61622:PGM2L1
gene id: 61622:PGM2L1
uniprot id: A0A2K6Q0V0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61622:MLEC
gene id: 61622:MLEC
uniprot id: A0A2K6NQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TRUB2
gene id: 61622:TRUB2
uniprot id: A0A2K6RDY8
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

61622:IL1RAP
gene id: 61622:IL1RAP
uniprot id: A0A2K6NUF5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:C6
gene id: 61622:C6
uniprot id: A0A2K6NWW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:DGAT2
gene id: 61622:DGAT2
uniprot id: A0A2K6NZQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:XPNPEP2
gene id: 61622:XPNPEP2
uniprot id: A0A2K6NU94
names: Similarity
messages: Belongs to the peptidase M24B family.

61622:SRPX2
gene id: 61622:SRPX2
uniprot id: A0A2K6QM54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IGFBP5
gene id: 61622:IGFBP5
uniprot id: A0A2K6PUQ7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:PTDSS1
gene id: 61622:PTDSS1
uniprot id: A0A2K6PVZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:POLA1
gene id: 61622:POLA1
uniprot id: A0A2K6RVU3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

61622:EGFL8
gene id: 61622:EGFL8
uniprot id: A0A2K6P3L4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IER3IP1
gene id: 61622:IER3IP1
uniprot id: A0A2K6RB02
names: Similarity
messages: Belongs to the YOS1 family.

61622:SLC6A5
gene id: 61622:SLC6A5
uniprot id: A0A2K6R3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:SOSTDC1
gene id: 61622:SOSTDC1
uniprot id: A0A2K6PY56
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TERT
gene id: 61622:TERT
uniprot id: A0A2K6PK27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

61622:GDPD5
gene id: 61622:GDPD5
uniprot id: A0A2K6PHA8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:TMPRSS11D
gene id: 61622:TMPRSS11D
uniprot id: A0A2K6PIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:MTFR2
gene id: 61622:MTFR2
uniprot id: A0A2K6PX24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

61622:LOC104671059
gene id: 61622:LOC104671059
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:RPS6KA1
gene id: 61622:RPS6KA1
uniprot id: A0A2K6QS01
uniprot id: A0A2K6QS13
uniprot id: A0A2K6QS34
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61622:PAICS
gene id: 61622:PAICS
uniprot id: A0A2K6QWN2
uniprot id: A0A2K6QWQ5
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

61622:S1PR3
gene id: 61622:S1PR3
uniprot id: A0A2K6N9A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:NCEH1
gene id: 61622:NCEH1
uniprot id: A0A2K6NAX7
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61622:DOK4
gene id: 61622:DOK4
uniprot id: A0A2K6PW78
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

61622:NAA60
gene id: 61622:NAA60
uniprot id: A0A2K6R3T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

61622:BRD1
gene id: 61622:BRD1
uniprot id: A0A2K6PLC1
names: Subcellular Location Annotation
messages: Nucleus

61622:NKX2-2
gene id: 61622:NKX2-2
uniprot id: A0A2K6R2L3
names: Subcellular Location Annotation
messages: Nucleus

61622:LEF1
gene id: 61622:LEF1
uniprot id: A0A2K6QWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

61622:CBS
gene id: 61622:CBS
uniprot id: A0A2K6NK06
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

61622:HACL1
gene id: 61622:HACL1
uniprot id: A0A2K6PJ26
uniprot id: A0A2K6PJ33
names: Similarity
messages: Belongs to the TPP enzyme family.

61622:MINDY2
gene id: 61622:MINDY2
uniprot id: A0A2K6NZS6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61622:CPT1C
gene id: 61622:CPT1C
uniprot id: A0A2K6P1K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:HMX2
gene id: 61622:HMX2
uniprot id: A0A2K6QLW9
names: Subcellular Location Annotation
messages: Nucleus

61622:UXS1
gene id: 61622:UXS1
uniprot id: A0A2K6PQX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

61622:EML1
gene id: 61622:EML1
uniprot id: A0A2K6NXV0
uniprot id: A0A2K6NXV5
names: Similarity
messages: Belongs to the WD repeat EMAP family.

61622:TRPC6
gene id: 61622:TRPC6
uniprot id: A0A2K6Q8N7
names: Subcellular Location Annotation
messages: Membrane

61622:RPL26L1
gene id: 61622:RPL26L1
uniprot id: A0A2K6PX37
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:E2F8
gene id: 61622:E2F8
uniprot id: A0A2K6PIL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:KMO
gene id: 61622:KMO
uniprot id: A0A2K6QI22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

61622:KCNH2
gene id: 61622:KCNH2
uniprot id: A0A2K6PII3
names: Subcellular Location Annotation
messages: Membrane

61622:KDELR3
gene id: 61622:KDELR3
uniprot id: A0A2K6PA63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:MANEAL
gene id: 61622:MANEAL
uniprot id: A0A2K6PRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:TGS1
gene id: 61622:TGS1
uniprot id: A0A2K6Q180
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

61622:HNF1A
gene id: 61622:HNF1A
uniprot id: A0A2K6NLC5
uniprot id: A0A2K6NLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

61622:ATP5PF
gene id: 61622:ATP5PF
uniprot id: A0A2K6NYE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

61622:SLC12A5
gene id: 61622:SLC12A5
uniprot id: A0A2K6PJZ3
uniprot id: A0A2K6R7Q2
uniprot id: A0A2K6R7R0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Membrane
messages: extracellular matrix

61622:FAM53C
gene id: 61622:FAM53C
uniprot id: A0A2K6RTU7
names: Similarity
messages: Belongs to the FAM53 family.

61622:TBL1XR1
gene id: 61622:TBL1XR1
uniprot id: A0A2K6RFV8
uniprot id: A0A2K6RFZ7
names: Similarity
messages: Belongs to the WD repeat EBI family.

61622:FAM221B
gene id: 61622:FAM221B
uniprot id: A0A2K6PSL2
names: Similarity
messages: Belongs to the FAM221 family.

61622:NR1D1
gene id: 61622:NR1D1
uniprot id: A0A2K6NN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:DEFB126
gene id: 61622:DEFB126
uniprot id: A0A2K6NWW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:BET1
gene id: 61622:BET1
uniprot id: A0A2K6PV89
names: Subcellular Location Annotation
messages: Membrane

61622:NTS
gene id: 61622:NTS
uniprot id: A0A2K6RTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

61622:FAM228A
gene id: 61622:FAM228A
uniprot id: A0A2K6Q0X1
names: Similarity
messages: Belongs to the FAM228 family.

61622:GRIK3
gene id: 61622:GRIK3
uniprot id: A0A2K6PQP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:GLYAT
gene id: 61622:GLYAT
uniprot id: A0A2K6QF97
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61622:UBA6
gene id: 61622:UBA6
uniprot id: A0A2K6PTQ7
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61622:MMP12
gene id: 61622:MMP12
uniprot id: A0A2K6PQ43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:ALAS1
gene id: 61622:ALAS1
uniprot id: A0A2K6NEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

61622:NOP10
gene id: 61622:NOP10
uniprot id: A0A2K6RLH8
names: Similarity
messages: Belongs to the NOP10 family.

61622:SLC9A6
gene id: 61622:SLC9A6
uniprot id: A0A2K6PJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

61622:UCKL1
gene id: 61622:UCKL1
uniprot id: A0A2K6PQW4
names: Similarity
messages: Belongs to the uridine kinase family.

61622:EPO
gene id: 61622:EPO
uniprot id: A0A1L1WKB9
uniprot id: A0A2K6RUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

61622:NUP210L
gene id: 61622:NUP210L
uniprot id: A0A2K6QB53
uniprot id: A0A2K6QB69
names: Similarity
messages: Belongs to the NUP210 family.

61622:SYN2
gene id: 61622:SYN2
uniprot id: A0A2K6R070
names: Similarity
messages: Belongs to the synapsin family.

61622:DHPS
gene id: 61622:DHPS
uniprot id: A0A2K6QXF7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

61622:LOC104682241
gene id: 61622:LOC104682241
uniprot id: A0A2K6RXU3
names: Similarity
messages: Belongs to the serpin family.

61622:LOC104660775
gene id: 61622:LOC104660775
uniprot id: A0A2K6QT12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

61622:TRH
gene id: 61622:TRH
uniprot id: A0A2K6P507
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

61622:CPXM2
gene id: 61622:CPXM2
uniprot id: A0A2K6PZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61622:BMP5
gene id: 61622:BMP5
uniprot id: A0A2K6RVH4
names: Similarity
messages: Belongs to the TGF-beta family.

61622:MST1R
gene id: 61622:MST1R
uniprot id: A0A2K6QD56
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:VWC2L
gene id: 61622:VWC2L
uniprot id: A0A2K6N8E6
names: Subcellular Location Annotation
messages: Synapse

61622:ANPEP
gene id: 61622:ANPEP
uniprot id: A0A2K6PSB9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:LOC104681086
gene id: 61622:LOC104681086
uniprot id: A0A2K6PCJ8
names: Similarity
messages: Belongs to the GAGE family.

61622:EFNB1
gene id: 61622:EFNB1
uniprot id: A0A2K6PCK8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FDPS
gene id: 61622:FDPS
uniprot id: A0A2K6QQ60
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61622:SPIRE2
gene id: 61622:SPIRE2
uniprot id: A0A2K6NGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

61622:FAM160A2
gene id: 61622:FAM160A2
uniprot id: A0A2K6N7E1
names: Similarity
messages: Belongs to the FHIP family.

61622:FGGY
gene id: 61622:FGGY
uniprot id: A0A2K6NWC5
names: Similarity
messages: Belongs to the FGGY kinase family.

61622:CALCR
gene id: 61622:CALCR
uniprot id: A0A2K6RNJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

61622:ATXN10
gene id: 61622:ATXN10
uniprot id: A0A2K6N9V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
messages: perinuclear region

61622:CCDC124
gene id: 61622:CCDC124
uniprot id: A0A2K6QBM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

61622:AASS
gene id: 61622:AASS
uniprot id: A0A2K6QB68
uniprot id: A0A2K6QB75
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

61622:RPL32
gene id: 61622:RPL32
uniprot id: A0A2K6NDE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

61622:GPR12
gene id: 61622:GPR12
uniprot id: A0A2K6ND89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GADD45B
gene id: 61622:GADD45B
uniprot id: A0A2K6R6K7
names: Similarity
messages: Belongs to the GADD45 family.

61622:HSCB
gene id: 61622:HSCB
uniprot id: A0A2K6R0X8
names: Similarity
messages: Belongs to the HscB family.

61622:FAM193B
gene id: 61622:FAM193B
uniprot id: A0A2K6P418
names: Similarity
messages: Belongs to the FAM193 family.

61622:VIPAS39
gene id: 61622:VIPAS39
uniprot id: A0A2K6R5Z2
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

61622:GNL2
gene id: 61622:GNL2
uniprot id: A0A2K6NH85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

61622:LOC104663552
gene id: 61622:LOC104663552
uniprot id: A0A2K6QIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

61622:TNS4
gene id: 61622:TNS4
uniprot id: A0A2K6RDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

61622:SCGB2B2
gene id: 61622:SCGB2B2
uniprot id: A0A2K6P6G6
names: Subcellular Location Annotation
messages: Secreted

61622:CALHM5
gene id: 61622:CALHM5
uniprot id: A0A2K6NXM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61622:RGS9
gene id: 61622:RGS9
uniprot id: A0A2K6PVK4
names: Subcellular Location Annotation
messages: Membrane

61622:LIMK2
gene id: 61622:LIMK2
uniprot id: A0A2K6RLF2
uniprot id: A0A2K6RLI0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

61622:FBLN2
gene id: 61622:FBLN2
uniprot id: A0A2K6Q7I6
uniprot id: A0A2K6Q7J1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:MDH1B
gene id: 61622:MDH1B
uniprot id: A0A2K6NC79
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

61622:SERPINA12
gene id: 61622:SERPINA12
uniprot id: A0A2K6QM78
names: Similarity
messages: Belongs to the serpin family.

61622:CCL20
gene id: 61622:CCL20
uniprot id: A0A2K6PK32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:IFI35
gene id: 61622:IFI35
uniprot id: A0A2K6NSA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

61622:SERPINB5
gene id: 61622:SERPINB5
uniprot id: A0A2K6RRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

61622:CCNO
gene id: 61622:CCNO
uniprot id: A0A2K6QRC6
names: Similarity
messages: Belongs to the cyclin family.

61622:ITGAV
gene id: 61622:ITGAV
uniprot id: A0A2K6NBD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:LOC104678905
gene id: 61622:LOC104678905
uniprot id: A0A2K6PPM2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CHRNA6
gene id: 61622:CHRNA6
uniprot id: A0A2K6QHN9
uniprot id: A0A2K6QHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LOC104662597
gene id: 61622:LOC104662597
uniprot id: A0A2K6NS74
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:GABRQ
gene id: 61622:GABRQ
uniprot id: A0A2K6N752
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:DYNLRB2
gene id: 61622:DYNLRB2
uniprot id: A0A2K6PVG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

61622:LOC104674022
gene id: 61622:LOC104674022
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:EHD4
gene id: 61622:EHD4
uniprot id: A0A2K6PY39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

61622:CLK4
gene id: 61622:CLK4
uniprot id: A0A2K6RQ64
uniprot id: A0A2K6RQA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GLRX
gene id: 61622:GLRX
uniprot id: A0A2K6PJM6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

61622:UBE2G2
gene id: 61622:UBE2G2
uniprot id: A0A2K6P0V6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:STOML1
gene id: 61622:STOML1
uniprot id: A0A2K6P4Z5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

61622:PPARD
gene id: 61622:PPARD
uniprot id: A0A2K6NYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:LOC104678238
gene id: 61622:LOC104678238
uniprot id: A0A2K6QRW7
uniprot id: A0A2K6QRX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:CMBL
gene id: 61622:CMBL
uniprot id: A0A2K6PJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

61622:MCRIP1
gene id: 61622:MCRIP1
uniprot id: A0A2K6RPT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

61622:LPCAT2
gene id: 61622:LPCAT2
uniprot id: A0A2K6NQG1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

61622:LOC104671786
gene id: 61622:LOC104671786
uniprot id: A0A2K6NAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61622:EIF2D
gene id: 61622:EIF2D
uniprot id: A0A2K6PV60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

61622:TRIM9
gene id: 61622:TRIM9
uniprot id: A0A2K6QRL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

61622:CHRNA7
gene id: 61622:CHRNA7
uniprot id: A0A2K6PTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LOC104663541
gene id: 61622:LOC104663541
uniprot id: A0A2K6NT40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ITGB5
gene id: 61622:ITGB5
uniprot id: A0A2K6PYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

61622:CORO1A
gene id: 61622:CORO1A
uniprot id: A0A2K6R7R2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

61622:OIP5
gene id: 61622:OIP5
uniprot id: A0A2K6PA72
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

61622:GEM
gene id: 61622:GEM
uniprot id: A0A2K6RTM3
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61622:SLC6A6
gene id: 61622:SLC6A6
uniprot id: A0A2K6QSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

61622:SASS6
gene id: 61622:SASS6
uniprot id: A0A2K6PXH2
names: Subcellular Location Annotation
messages: centrosome

61622:DXO
gene id: 61622:DXO
uniprot id: A0A2K6Q3R0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

61622:SLC5A1
gene id: 61622:SLC5A1
uniprot id: A0A2K6P6A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:MOCS2
gene id: 61622:MOCS2
uniprot id: A0A2K6QET5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

61622:ADRA1A
gene id: 61622:ADRA1A
uniprot id: A0A2K6R3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

61622:LOC104681600
gene id: 61622:LOC104681600
uniprot id: A0A2K6NRQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

61622:CER1
gene id: 61622:CER1
uniprot id: A0A2K6REV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:MBOAT1
gene id: 61622:MBOAT1
uniprot id: A0A2K6PMC5
names: Subcellular Location Annotation
messages: Membrane

61622:IDNK
gene id: 61622:IDNK
uniprot id: A0A2K6R7K6
uniprot id: A0A2K6R7K7
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

61622:FLT1
gene id: 61622:FLT1
uniprot id: A0A2K6RLG1
uniprot id: A0A2K6RLH4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Membrane

61622:STXBP2
gene id: 61622:STXBP2
uniprot id: A0A2K6PF80
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61622:POMT2
gene id: 61622:POMT2
uniprot id: A0A2K6NTI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

61622:CFAP97D1
gene id: 61622:CFAP97D1
uniprot id: A0A2K6PLJ7
names: Similarity
messages: Belongs to the CFAP97 family.

61622:LAMTOR5
gene id: 61622:LAMTOR5
uniprot id: A0A2K6RP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

61622:KEG34 p05
gene id: 61622:KEG34_p05
uniprot id: Q15GN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ST7
gene id: 61622:ST7
uniprot id: A0A2K6QDW7
uniprot id: A0A2K6QDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

61622:LOC104668848
gene id: 61622:LOC104668848
uniprot id: A0A2K6QU79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TIPARP
gene id: 61622:TIPARP
uniprot id: A0A2K6R5T1
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:LOC104663264
gene id: 61622:LOC104663264
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:LOC104680528
gene id: 61622:LOC104680528
uniprot id: A0A2K6R477
names: Similarity
messages: Belongs to the CBP3 family.

61622:LOC104674240
gene id: 61622:LOC104674240
uniprot id: A0A2K6PZZ9
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

61622:TECRL
gene id: 61622:TECRL
uniprot id: A0A2K6PA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

61622:RGS5
gene id: 61622:RGS5
uniprot id: A0A2K6NFB7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

61622:SLC35C2
gene id: 61622:SLC35C2
uniprot id: A0A2K6PUZ5
names: Subcellular Location Annotation
messages: Membrane

61622:NPTX1
gene id: 61622:NPTX1
uniprot id: A0A2K6NL75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SCAMP3
gene id: 61622:SCAMP3
uniprot id: A0A2K6NXJ0
uniprot id: A0A2K6NXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

61622:GPR1
gene id: 61622:GPR1
uniprot id: A0A2K6NI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

61622:HPS6
gene id: 61622:HPS6
uniprot id: A0A2K6NHR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

61622:MMP16
gene id: 61622:MMP16
uniprot id: A0A2K6PVV2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:FAM98C
gene id: 61622:FAM98C
uniprot id: A0A2K6NIU7
names: Similarity
messages: Belongs to the FAM98 family.

61622:RNF34
gene id: 61622:RNF34
uniprot id: A0A2K6QYA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: cytosol

61622:TERF2IP
gene id: 61622:TERF2IP
uniprot id: A0A2K6QY86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

61622:HS3ST3A1
gene id: 61622:HS3ST3A1
uniprot id: A0A2K6Q0C4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:HECTD1
gene id: 61622:HECTD1
uniprot id: A0A2K6NHI6
uniprot id: A0A2K6NHN0
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

61622:POP5
gene id: 61622:POP5
uniprot id: A0A2K6RT02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

61622:TRAF1
gene id: 61622:TRAF1
uniprot id: A0A2K6RRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

61622:FAM110B
gene id: 61622:FAM110B
uniprot id: A0A2K6NRR1
names: Similarity
messages: Belongs to the FAM110 family.

61622:LOC104681218
gene id: 61622:LOC104681218
uniprot id: A0A2K6QYM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

61622:FOXP3
gene id: 61622:FOXP3
uniprot id: A0A2K6QM36
uniprot id: A0A2K6QM63
names: Subcellular Location Annotation
messages: Nucleus

61622:SPHKAP
gene id: 61622:SPHKAP
uniprot id: A0A2K6PLY2
uniprot id: A0A2K6PM06
names: Similarity
messages: Belongs to the AKAP110 family.

61622:TMEM184A
gene id: 61622:TMEM184A
uniprot id: A0A2K6RG85
names: Subcellular Location Annotation
messages: Membrane

61622:CHRNA1
gene id: 61622:CHRNA1
uniprot id: A0A2K6RXR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:NMT1
gene id: 61622:NMT1
uniprot id: A0A2K6NJJ2
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

61622:DUSP26
gene id: 61622:DUSP26
uniprot id: A0A2K6NRP4
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61622:MYOD1
gene id: 61622:MYOD1
uniprot id: A0A2K6QJT8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

61622:RNASEH2A
gene id: 61622:RNASEH2A
uniprot id: A0A2K6RJF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

61622:CXCL16
gene id: 61622:CXCL16
uniprot id: A0A2K6PFP6
names: Subcellular Location Annotation
messages: Membrane

61622:NDFIP2
gene id: 61622:NDFIP2
uniprot id: A0A2K6QV02
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

61622:WDR48
gene id: 61622:WDR48
uniprot id: A0A2K6P1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

61622:ELSPBP1
gene id: 61622:ELSPBP1
uniprot id: A0A2K6R9U4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SERPINB12
gene id: 61622:SERPINB12
uniprot id: A0A2K6Q0P4
names: Similarity
messages: Belongs to the serpin family.

61622:PTP4A3
gene id: 61622:PTP4A3
uniprot id: A0A2K6Q6U8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61622:DENND6A
gene id: 61622:DENND6A
uniprot id: A0A2K6QPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

61622:TEKT2
gene id: 61622:TEKT2
uniprot id: A0A2K6QRN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61622:C8H19orf53
gene id: 61622:C8H19orf53
uniprot id: A0A2K6PLZ9
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

61622:TIGD2
gene id: 61622:TIGD2
uniprot id: A0A2K6QFD2
names: Subcellular Location Annotation
messages: Nucleus

61622:ALG10
gene id: 61622:ALG10
uniprot id: A0A2K6NYC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:THEMIS2
gene id: 61622:THEMIS2
uniprot id: A0A2K6NPI2
names: Similarity
messages: Belongs to the themis family.

61622:NNAT
gene id: 61622:NNAT
uniprot id: A0A2K6QTL5
uniprot id: A0A2K6QTP1
names: Similarity
messages: Belongs to the neuronatin family.

61622:MYBL1
gene id: 61622:MYBL1
uniprot id: A0A2K6RJ70
uniprot id: A0A2K6RJ77
names: Subcellular Location Annotation
messages: Nucleus

61622:RTN2
gene id: 61622:RTN2
uniprot id: A0A2K6QK29
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:AKAP12
gene id: 61622:AKAP12
uniprot id: A0A2K6QL06
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104673722
gene id: 61622:LOC104673722
uniprot id: A0A2K6NBL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

61622:SNRPA
gene id: 61622:SNRPA
uniprot id: A0A2K6RCF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

61622:PCID2
gene id: 61622:PCID2
uniprot id: A0A2K6QXU9
names: Similarity
messages: Belongs to the CSN12 family.

61622:CD53
gene id: 61622:CD53
uniprot id: A0A2K6PCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:IDI1
gene id: 61622:IDI1
uniprot id: A0A2K6R7A5
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

61622:SPCS3
gene id: 61622:SPCS3
uniprot id: A0A2K6QUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:BICD2
gene id: 61622:BICD2
uniprot id: A0A2K6PZY9
uniprot id: A0A2K6Q004
names: Similarity
messages: Belongs to the BicD family.

61622:NLRP13
gene id: 61622:NLRP13
uniprot id: A0A2K6R3Q9
names: Similarity
messages: Belongs to the NLRP family.

61622:ASPN
gene id: 61622:ASPN
uniprot id: A0A2K6NNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

61622:ELOVL3
gene id: 61622:ELOVL3
uniprot id: A0A2K6QWS3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61622:PTPRG
gene id: 61622:PTPRG
uniprot id: A0A2K6R724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61622:SCAMP2
gene id: 61622:SCAMP2
uniprot id: A0A2K6N721
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

61622:LOC115891967
gene id: 61622:LOC115891967
uniprot id: A0A2K6NQ35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LYPLAL1
gene id: 61622:LYPLAL1
uniprot id: A0A2K6PAK5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

61622:RPL38
gene id: 61622:RPL38
uniprot id: A0A2K6NIF4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

61622:LOC104668685
gene id: 61622:LOC104668685
uniprot id: A0A2K6R705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

61622:STK17B
gene id: 61622:STK17B
uniprot id: A0A2K6QX26
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SMIM18
gene id: 61622:SMIM18
uniprot id: A0A2K6NJ38
names: Subcellular Location Annotation
messages: Membrane

61622:EPOR
gene id: 61622:EPOR
uniprot id: A0A2K6RF53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Forms homodimers on EPO stimulation.
messages: Membrane
messages: Receptor for erythropoietin.

61622:UBAP2
gene id: 61622:UBAP2
uniprot id: A0A2K6NEX0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:BEX1
gene id: 61622:BEX1
uniprot id: A0A2K6QK87
names: Similarity
messages: Belongs to the BEX family.

61622:STEAP1
gene id: 61622:STEAP1
uniprot id: A0A2K6NRQ2
names: Subcellular Location Annotation
messages: Membrane

61622:ATRAID
gene id: 61622:ATRAID
uniprot id: A0A2K6QVX1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CDPF1
gene id: 61622:CDPF1
uniprot id: A0A2K6QMM2
names: Similarity
messages: Belongs to the CDPF1 family.

61622:ARID1A
gene id: 61622:ARID1A
uniprot id: A0A2K6QA56
names: Subcellular Location Annotation
messages: Nucleus

61622:SPARC
gene id: 61622:SPARC
uniprot id: A0A2K6PQ30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

61622:LOC104671069
gene id: 61622:LOC104671069
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:OTP
gene id: 61622:OTP
uniprot id: A0A2K6NKN7
names: Subcellular Location Annotation
messages: Nucleus

61622:TMEM50B
gene id: 61622:TMEM50B
uniprot id: A0A2K6Q756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

61622:ARL5A
gene id: 61622:ARL5A
uniprot id: A0A2K6QX79
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:NIBAN2
gene id: 61622:NIBAN2
uniprot id: A0A2K6Q061
names: Similarity
messages: Belongs to the Niban family.

61622:GALNT2
gene id: 61622:GALNT2
uniprot id: A0A2K6QYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:DHRS7
gene id: 61622:DHRS7
uniprot id: A0A2K6QZZ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:SUV39H2
gene id: 61622:SUV39H2
uniprot id: A0A2K6QR79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

61622:ZC3HAV1
gene id: 61622:ZC3HAV1
uniprot id: A0A2K6R9N7
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:BSCL2
gene id: 61622:BSCL2
uniprot id: A0A2K6QCG6
uniprot id: A0A2K6QCH6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:POP7
gene id: 61622:POP7
uniprot id: A0A2K6NV88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

61622:SRP54
gene id: 61622:SRP54
uniprot id: A0A2K6R3N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

61622:GPM6B
gene id: 61622:GPM6B
uniprot id: A0A2K6R6T6
uniprot id: A0A2K6R6T7
uniprot id: A0A2K6R6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61622:LOC104657389
gene id: 61622:LOC104657389
uniprot id: A0A2K6NM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

61622:RNF31
gene id: 61622:RNF31
uniprot id: A0A2K6RSH3
names: Similarity
messages: Belongs to the RBR family.

61622:CENPS
gene id: 61622:CENPS
uniprot id: A0A2K6N705
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

61622:KCNK17
gene id: 61622:KCNK17
uniprot id: A0A2K6NBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:FAM83E
gene id: 61622:FAM83E
uniprot id: A0A2K6NW75
names: Similarity
messages: Belongs to the FAM83 family.

61622:DHX58
gene id: 61622:DHX58
uniprot id: A0A2K6Q5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

61622:RABEP2
gene id: 61622:RABEP2
uniprot id: A0A2K6RA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

61622:TRIM41
gene id: 61622:TRIM41
uniprot id: A0A2K6QAE3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:TPMT
gene id: 61622:TPMT
uniprot id: A0A2K6QYF3
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

61622:ANP32B
gene id: 61622:ANP32B
uniprot id: A0A2K6Q8J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

61622:SSTR3
gene id: 61622:SSTR3
uniprot id: A0A2K6NPE2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SEC22A
gene id: 61622:SEC22A
uniprot id: A0A2K6NNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

61622:CBFA2T2
gene id: 61622:CBFA2T2
uniprot id: A0A2K6Q2Q3
names: Similarity
messages: Belongs to the CBFA2T family.

61622:FH
gene id: 61622:FH
uniprot id: A0A2K6REZ2
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

61622:RHBDL1
gene id: 61622:RHBDL1
uniprot id: A0A2K6N977
names: Subcellular Location Annotation
messages: Membrane

61622:ECHDC1
gene id: 61622:ECHDC1
uniprot id: A0A2K6NW34
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

61622:RFC1
gene id: 61622:RFC1
uniprot id: A0A2K6NF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

61622:IL4
gene id: 61622:IL4
uniprot id: A0A2K6RBZ7
uniprot id: A0A2K6RC32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

61622:RAB3B
gene id: 61622:RAB3B
uniprot id: A0A2K6QSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

61622:LOC104678132
gene id: 61622:LOC104678132
uniprot id: A0A2K6NLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PNMT
gene id: 61622:PNMT
uniprot id: A0A2K6QYH3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

61622:SNRNP27
gene id: 61622:SNRNP27
uniprot id: A0A2K6PHY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

61622:MFGE8
gene id: 61622:MFGE8
uniprot id: A0A2K6PCX6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LSR
gene id: 61622:LSR
uniprot id: A0A2K6QKQ6
uniprot id: A0A2K6QKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

61622:POLR2D
gene id: 61622:POLR2D
uniprot id: A0A2K6NN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

61622:DIS3
gene id: 61622:DIS3
uniprot id: A0A2K6NFL6
uniprot id: A0A2K6NFL8
names: Similarity
messages: Belongs to the RNR ribonuclease family.

61622:CCDC172
gene id: 61622:CCDC172
uniprot id: A0A2K6QTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

61622:JPT2
gene id: 61622:JPT2
uniprot id: A0A2K6NQ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

61622:SLC25A3
gene id: 61622:SLC25A3
uniprot id: A0A2K6PLG5
uniprot id: A0A2K6PLH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

61622:GALK2
gene id: 61622:GALK2
uniprot id: A0A2K6Q0S9
uniprot id: A0A2K6Q0T5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

61622:SYNPR
gene id: 61622:SYNPR
uniprot id: A0A2K6N9I9
uniprot id: A0A2K6N9K2
uniprot id: A0A2K6N9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61622:AGMAT
gene id: 61622:AGMAT
uniprot id: A0A2K6PMG3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

61622:RETREG3
gene id: 61622:RETREG3
uniprot id: A0A2K6P1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NUP98
gene id: 61622:NUP98
uniprot id: A0A2K6PFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

61622:RNH1
gene id: 61622:RNH1
uniprot id: A0A2K6N8C2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

61622:DCT
gene id: 61622:DCT
uniprot id: A0A2K6PAK1
uniprot id: A0A2K6PAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61622:SFT2D2
gene id: 61622:SFT2D2
uniprot id: A0A2K6QW42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

61622:UBE4A
gene id: 61622:UBE4A
uniprot id: A0A2K6RPA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

61622:EPYC
gene id: 61622:EPYC
uniprot id: A0A2K6NL33
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

61622:CD47
gene id: 61622:CD47
uniprot id: A0A2K6P8M3
uniprot id: A0A2K6P8Q8
uniprot id: A0A2K6P8T5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:COPS6
gene id: 61622:COPS6
uniprot id: A0A2K6Q5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

61622:FN1
gene id: 61622:FN1
uniprot id: A0A2K6PZ96
uniprot id: A0A2K6PZ99
uniprot id: A0A2K6PZC7
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

61622:UVSSA
gene id: 61622:UVSSA
uniprot id: A0A2K6P060
names: Similarity
messages: Belongs to the UVSSA family.

61622:ERMAP
gene id: 61622:ERMAP
uniprot id: A0A2K6RT43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Cytoplasm
messages: Membrane

61622:B4GALNT1
gene id: 61622:B4GALNT1
uniprot id: A0A2K6PH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104671155
gene id: 61622:LOC104671155
uniprot id: A0A2K6Q960
uniprot id: A0A2K6Q966
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:KIF15
gene id: 61622:KIF15
uniprot id: A0A2K6PLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
messages: spindle

61622:THG1L
gene id: 61622:THG1L
uniprot id: A0A2K6RV38
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

61622:YIPF4
gene id: 61622:YIPF4
uniprot id: A0A2K6RW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:C12H19orf54
gene id: 61622:C12H19orf54
uniprot id: A0A2K6P4K7
names: Similarity
messages: Belongs to the ACTMAP family.

61622:MRPL44
gene id: 61622:MRPL44
uniprot id: A0A2K6PHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

61622:SVOP
gene id: 61622:SVOP
uniprot id: A0A2K6QZ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61622:ARSK
gene id: 61622:ARSK
uniprot id: A0A2K6PVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

61622:PHACTR1
gene id: 61622:PHACTR1
uniprot id: A0A2K6PPG1
uniprot id: A0A2K6PPI6
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

61622:OSBPL3
gene id: 61622:OSBPL3
uniprot id: A0A2K6NPI3
names: Similarity
messages: Belongs to the OSBP family.

61622:SMPX
gene id: 61622:SMPX
uniprot id: A0A2K6R087
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

61622:AZIN1
gene id: 61622:AZIN1
uniprot id: A0A2K6NSH0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

61622:EFNA3
gene id: 61622:EFNA3
uniprot id: A0A2K6P8G2
uniprot id: A0A2K6P8M5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ACRBP
gene id: 61622:ACRBP
uniprot id: A0A2K6Q9F8
names: Subcellular Location Annotation
messages: acrosome

61622:EFHC1
gene id: 61622:EFHC1
uniprot id: A0A2K6NMX0
names: Subcellular Location Annotation
messages: cilium axoneme

61622:ENTPD6
gene id: 61622:ENTPD6
uniprot id: A0A2K6PC30
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:LOC104668069
gene id: 61622:LOC104668069
uniprot id: A0A2K6NRK7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

61622:GNA15
gene id: 61622:GNA15
uniprot id: A0A2K6Q3S7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61622:SLC16A7
gene id: 61622:SLC16A7
uniprot id: A0A2K6RP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

61622:PSMC2
gene id: 61622:PSMC2
uniprot id: A0A2K6PLK0
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:LOC104664525
gene id: 61622:LOC104664525
uniprot id: A0A2K6P2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:SPRTN
gene id: 61622:SPRTN
uniprot id: A0A2K6RIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

61622:GPR146
gene id: 61622:GPR146
uniprot id: A0A2K6ND31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CROT
gene id: 61622:CROT
uniprot id: A0A2K6RJU3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61622:TMEM116
gene id: 61622:TMEM116
uniprot id: A0A2K6QPY5
names: Subcellular Location Annotation
messages: Membrane

61622:FAM3D
gene id: 61622:FAM3D
uniprot id: A0A2K6PP92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61622:SOD2
gene id: 61622:SOD2
uniprot id: A0A2K6NUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

61622:SPICE1
gene id: 61622:SPICE1
uniprot id: A0A2K6PP02
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

61622:B3GAT2
gene id: 61622:B3GAT2
uniprot id: A0A2K6NK52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:MBOAT2
gene id: 61622:MBOAT2
uniprot id: A0A2K6RUP5
names: Subcellular Location Annotation
messages: Membrane

61622:PLPPR4
gene id: 61622:PLPPR4
uniprot id: A0A2K6PQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:LOC104679440
gene id: 61622:LOC104679440
uniprot id: A0A2K6NQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MRPL30
gene id: 61622:MRPL30
uniprot id: A0A2K6RQC7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

61622:MAPK14
gene id: 61622:MAPK14
uniprot id: A0A2K6QA65
uniprot id: A0A2K6QA67
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

61622:SLC37A1
gene id: 61622:SLC37A1
uniprot id: A0A2K6Q8L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

61622:LOC104676091
gene id: 61622:LOC104676091
uniprot id: A0A2K6QAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:STON1
gene id: 61622:STON1
uniprot id: A0A2K6QU73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

61622:MRPL51
gene id: 61622:MRPL51
uniprot id: A0A2K6NL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

61622:ANHX
gene id: 61622:ANHX
uniprot id: A0A2K6PF50
names: Subcellular Location Annotation
messages: Nucleus

61622:TRIM3
gene id: 61622:TRIM3
uniprot id: A0A2K6QU30
names: Similarity
messages: Belongs to the TRIM/RBCC family.

61622:OST4
gene id: 61622:OST4
uniprot id: A0A2K6N8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ABCA4
gene id: 61622:ABCA4
uniprot id: A0A2K6PYJ0
names: Subcellular Location Annotation
messages: Membrane

61622:CDK16
gene id: 61622:CDK16
uniprot id: A0A2K6R576
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GDF5
gene id: 61622:GDF5
uniprot id: A0A2K6NIS5
names: Similarity
messages: Belongs to the TGF-beta family.

61622:VPS37C
gene id: 61622:VPS37C
uniprot id: A0A2K6RHA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:ADAM9
gene id: 61622:ADAM9
uniprot id: A0A2K6QVA2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:RPAP2
gene id: 61622:RPAP2
uniprot id: A0A2K6PMX9
uniprot id: A0A2K6PN34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

61622:PARP15
gene id: 61622:PARP15
uniprot id: A0A2K6P497
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:ENGASE
gene id: 61622:ENGASE
uniprot id: A0A2K6N811
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

61622:SERF2
gene id: 61622:SERF2
uniprot id: A0A2K6NBR4
names: Similarity
messages: Belongs to the SERF family.

61622:VAX1
gene id: 61622:VAX1
uniprot id: A0A2K6QFT4
names: Subcellular Location Annotation
messages: Nucleus

61622:CREBL2
gene id: 61622:CREBL2
uniprot id: A0A2K6NX81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

61622:MPP5
gene id: 61622:MPP5
uniprot id: A0A2K6PHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: adherens junction
messages: tight junction

61622:FAM151B
gene id: 61622:FAM151B
uniprot id: A0A2K6PD75
names: Similarity
messages: Belongs to the FAM151 family.

61622:OCIAD1
gene id: 61622:OCIAD1
uniprot id: A0A2K6PN44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

61622:YIPF1
gene id: 61622:YIPF1
uniprot id: A0A2K6RU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

61622:PTTG1
gene id: 61622:PTTG1
uniprot id: A0A2K6RP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

61622:CCL13
gene id: 61622:CCL13
uniprot id: A0A2K6R776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:WDR44
gene id: 61622:WDR44
uniprot id: A0A2K6Q1H9
names: Subcellular Location Annotation
messages: trans-Golgi network

61622:TNFSF11
gene id: 61622:TNFSF11
uniprot id: A0A2K6NVT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

61622:DLL1
gene id: 61622:DLL1
uniprot id: A0A2K6P7J9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61622:TWISTNB
gene id: 61622:TWISTNB
uniprot id: A0A2K6QW86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61622:PPP1R14A
gene id: 61622:PPP1R14A
uniprot id: A0A2K6N6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

61622:PGAP1
gene id: 61622:PGAP1
uniprot id: A0A2K6P888
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

61622:PAPPA2
gene id: 61622:PAPPA2
uniprot id: A0A2K6QU17
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TLN2
gene id: 61622:TLN2
uniprot id: A0A2K6Q2S6
names: Subcellular Location Annotation
messages: cytoskeleton

61622:ALKBH3
gene id: 61622:ALKBH3
uniprot id: A0A2K6R917
names: Similarity
messages: Belongs to the alkB family.

61622:MCM10
gene id: 61622:MCM10
uniprot id: A0A2K6RXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

61622:APOL5
gene id: 61622:APOL5
uniprot id: A0A2K6PE62
names: Similarity
messages: Belongs to the apolipoprotein L family.

61622:LGI3
gene id: 61622:LGI3
uniprot id: A0A2K6PF33
names: Subcellular Location Annotation
messages: Secreted

61622:CCDC25
gene id: 61622:CCDC25
uniprot id: A0A2K6NVB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

61622:CPA4
gene id: 61622:CPA4
uniprot id: A0A2K6Q439
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:PIWIL1
gene id: 61622:PIWIL1
uniprot id: A0A2K6P951
names: Similarity
messages: Belongs to the argonaute family.

61622:WDR4
gene id: 61622:WDR4
uniprot id: A0A2K6QXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

61622:LOC104678332
gene id: 61622:LOC104678332
uniprot id: A0A2K6QMC3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:CHST9
gene id: 61622:CHST9
uniprot id: A0A2K6Q3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:DAPK3
gene id: 61622:DAPK3
uniprot id: A0A2K6RX22
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:CHST8
gene id: 61622:CHST8
uniprot id: A0A2K6QJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:NIP7
gene id: 61622:NIP7
uniprot id: A0A2K6NRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

61622:BACE1
gene id: 61622:BACE1
uniprot id: A0A2K6P448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: Secreted
messages: trans-Golgi network

61622:IL1A
gene id: 61622:IL1A
uniprot id: A0A2K6NJ18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

61622:KIAA1191
gene id: 61622:KIAA1191
uniprot id: A0A2K6PEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

61622:LOC104679069
gene id: 61622:LOC104679069
uniprot id: A0A2K6NED0
names: Similarity
messages: Belongs to the serpin family.

61622:PTK7
gene id: 61622:PTK7
uniprot id: A0A2K6RDN0
names: Subcellular Location Annotation
messages: Membrane

61622:KIF20B
gene id: 61622:KIF20B
uniprot id: A0A2K6RSU8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:LOC104671809
gene id: 61622:LOC104671809
uniprot id: A0A2K6P455
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:CHD4
gene id: 61622:CHD4
uniprot id: A0A2K6RAM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

61622:DOLPP1
gene id: 61622:DOLPP1
uniprot id: A0A2K6R3U2
uniprot id: A0A2K6R3V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

61622:OGDH
gene id: 61622:OGDH
uniprot id: A0A2K6PGN5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

61622:RPL17
gene id: 61622:RPL17
uniprot id: A0A2K6NTV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61622:LOC104676364
gene id: 61622:LOC104676364
uniprot id: A0A2K6NLA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

61622:LOC104674542
gene id: 61622:LOC104674542
uniprot id: A0A2K6NKL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61622:PIWIL4
gene id: 61622:PIWIL4
uniprot id: A0A2K6NHP8
names: Similarity
messages: Belongs to the argonaute family.

61622:NGFR
gene id: 61622:NGFR
uniprot id: A0A2K6PLA6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MAS1
gene id: 61622:MAS1
uniprot id: A0A2K6NR71
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:MCMBP
gene id: 61622:MCMBP
uniprot id: A0A2K6NHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

61622:YJU2
gene id: 61622:YJU2
uniprot id: A0A2K6NKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

61622:RMND1
gene id: 61622:RMND1
uniprot id: A0A2K6Q7E0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

61622:ABL2
gene id: 61622:ABL2
uniprot id: A0A2K6RX24
uniprot id: A0A2K6RX39
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:SLC39A9
gene id: 61622:SLC39A9
uniprot id: A0A2K6R8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

61622:SNX4
gene id: 61622:SNX4
uniprot id: A0A2K6NEV3
names: Similarity
messages: Belongs to the sorting nexin family.

61622:DSC1
gene id: 61622:DSC1
uniprot id: A0A2K6NFN0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:EVA1B
gene id: 61622:EVA1B
uniprot id: A0A2K6PY61
names: Similarity
messages: Belongs to the EVA1 family.

61622:CCM2
gene id: 61622:CCM2
uniprot id: A0A2K6NQP2
uniprot id: A0A2K6NQQ1
names: Similarity
messages: Belongs to the CCM2 family.

61622:EYA2
gene id: 61622:EYA2
uniprot id: A0A2K6NRS2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

61622:TMEM11
gene id: 61622:TMEM11
uniprot id: A0A2K6NVN7
uniprot id: A0A2K6NVP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Plays a role in mitochondrial morphogenesis.

61622:TMEM165
gene id: 61622:TMEM165
uniprot id: A0A2K6R3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

61622:SLC15A2
gene id: 61622:SLC15A2
uniprot id: A0A2K6RDS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

61622:SENP8
gene id: 61622:SENP8
uniprot id: A0A2K6NJH0
names: Similarity
messages: Belongs to the peptidase C48 family.

61622:TMEM14C
gene id: 61622:TMEM14C
uniprot id: A0A2K6QFJ3
names: Similarity
messages: Belongs to the TMEM14 family.

61622:LOC104663773
gene id: 61622:LOC104663773
uniprot id: A0A2K6Q750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

61622:RAG1
gene id: 61622:RAG1
uniprot id: A0A2K6NRR9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.
messages: Homodimer.
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.

61622:CFAP206
gene id: 61622:CFAP206
uniprot id: A0A2K6NF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

61622:NRM
gene id: 61622:NRM
uniprot id: A0A2K6PAU7
uniprot id: A0A2K6PAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

61622:SENP5
gene id: 61622:SENP5
uniprot id: A0A2K6QFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

61622:UNC45A
gene id: 61622:UNC45A
uniprot id: A0A2K6NZA1
names: Subcellular Location Annotation
messages: perinuclear region

61622:TMX2
gene id: 61622:TMX2
uniprot id: A0A2K6PMC0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

61622:UTP14A
gene id: 61622:UTP14A
uniprot id: A0A2K6NVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

61622:MAPK7
gene id: 61622:MAPK7
uniprot id: A0A2K6RJY3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

61622:NPRL3
gene id: 61622:NPRL3
uniprot id: A0A2K6QSK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

61622:HSPD1
gene id: 61622:HSPD1
uniprot id: A0A2K6PDP4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

61622:HACD2
gene id: 61622:HACD2
uniprot id: A0A2K6PGF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CDX4
gene id: 61622:CDX4
uniprot id: A0A2K6P6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

61622:OGFOD1
gene id: 61622:OGFOD1
uniprot id: A0A2K6RHP0
names: Similarity
messages: Belongs to the TPA1 family.

61622:TNN
gene id: 61622:TNN
uniprot id: A0A2K6QD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

61622:GADD45GIP1
gene id: 61622:GADD45GIP1
uniprot id: A0A2K6PK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

61622:ING1
gene id: 61622:ING1
uniprot id: A0A2K6Q318
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:NUDT19
gene id: 61622:NUDT19
uniprot id: A0A2K6NI70
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61622:OOEP
gene id: 61622:OOEP
uniprot id: A0A2K6PL80
names: Similarity
messages: Belongs to the KHDC1 family.

61622:CDH1
gene id: 61622:CDH1
uniprot id: A0A2K6R725
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:ISL2
gene id: 61622:ISL2
uniprot id: A0A2K6RK91
names: Subcellular Location Annotation
messages: Nucleus

61622:UBR2
gene id: 61622:UBR2
uniprot id: A0A2K6R4B8
uniprot id: A0A2K6R4D3
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

61622:PSMA8
gene id: 61622:PSMA8
uniprot id: A0A2K6NHB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:TRMT2A
gene id: 61622:TRMT2A
uniprot id: A0A2K6QB00
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RANBP10
gene id: 61622:RANBP10
uniprot id: A0A2K6Q1M8
names: Similarity
messages: Belongs to the RANBP9/10 family.

61622:GET4
gene id: 61622:GET4
uniprot id: A0A2K6NC42
uniprot id: A0A2K6NC55
names: Similarity
messages: Belongs to the GET4 family.

61622:L3MBTL3
gene id: 61622:L3MBTL3
uniprot id: A0A2K6PM69
uniprot id: A0A2K6PM87
names: Subcellular Location Annotation
messages: Nucleus

61622:VPS35
gene id: 61622:VPS35
uniprot id: A0A2K6QZ79
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

61622:GOLT1A
gene id: 61622:GOLT1A
uniprot id: A0A2K6NX95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61622:CNN3
gene id: 61622:CNN3
uniprot id: A0A2K6P815
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

61622:YIF1B
gene id: 61622:YIF1B
uniprot id: A0A2K6QKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

61622:CCL22
gene id: 61622:CCL22
uniprot id: A0A2K6RSU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:TENM2
gene id: 61622:TENM2
uniprot id: A0A2K6Q1G3
uniprot id: A0A2K6Q1G7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GRP
gene id: 61622:GRP
uniprot id: A0A2K6QR84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

61622:RPS17
gene id: 61622:RPS17
uniprot id: A0A2K6NC87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

61622:THNSL1
gene id: 61622:THNSL1
uniprot id: A0A2K6NC83
names: Similarity
messages: Belongs to the threonine synthase family.

61622:CTSD
gene id: 61622:CTSD
uniprot id: A0A2K6Q181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

61622:OLFM2
gene id: 61622:OLFM2
uniprot id: A0A2K6P8R0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:MNAT1
gene id: 61622:MNAT1
uniprot id: A0A2K6Q4S8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

61622:KDR
gene id: 61622:KDR
uniprot id: A0A2K6Q7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

61622:EDC4
gene id: 61622:EDC4
uniprot id: A0A2K6PW37
uniprot id: A0A2K6PW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

61622:PFN3
gene id: 61622:PFN3
uniprot id: A0A2K6NNI3
names: Similarity
messages: Belongs to the profilin family.

61622:SIX6
gene id: 61622:SIX6
uniprot id: A0A2K6RVI2
names: Subcellular Location Annotation
messages: Nucleus

61622:ARRDC2
gene id: 61622:ARRDC2
uniprot id: A0A2K6PJA1
names: Similarity
messages: Belongs to the arrestin family.

61622:BCL7C
gene id: 61622:BCL7C
uniprot id: A0A2K6QYQ1
names: Similarity
messages: Belongs to the BCL7 family.

61622:DDX4
gene id: 61622:DDX4
uniprot id: A0A2K6RV64
uniprot id: A0A2K6RV71
uniprot id: A0A2K6RV80
uniprot id: A0A2K6RV88
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:EIF4E
gene id: 61622:EIF4E
uniprot id: A0A2K6PUJ2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61622:TASP1
gene id: 61622:TASP1
uniprot id: A0A2K6RU45
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

61622:LOC104679639
gene id: 61622:LOC104679639
uniprot id: A0A2K6NGI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

61622:KRT8
gene id: 61622:KRT8
uniprot id: A0A2K6P3S2
names: Similarity
messages: Belongs to the intermediate filament family.

61622:RPL3
gene id: 61622:RPL3
uniprot id: A0A2K6RLN0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

61622:AP3M2
gene id: 61622:AP3M2
uniprot id: A0A2K6PJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

61622:SLC13A3
gene id: 61622:SLC13A3
uniprot id: A0A2K6P053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:LOC104653690
gene id: 61622:LOC104653690
uniprot id: A0A2K6NC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:P2RY8
gene id: 61622:P2RY8
uniprot id: A0A2K6NHG4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PDCD10
gene id: 61622:PDCD10
uniprot id: A0A2K6NV76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61622:POLR3G
gene id: 61622:POLR3G
uniprot id: A0A2K6R4Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61622:SPAG9
gene id: 61622:SPAG9
uniprot id: A0A2K6QGN3
uniprot id: A0A2K6QGN7
uniprot id: A0A2K6QGP9
names: Similarity
messages: Belongs to the JIP scaffold family.

61622:BORCS7
gene id: 61622:BORCS7
uniprot id: A0A2K6P9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

61622:FBXO48
gene id: 61622:FBXO48
uniprot id: A0A2K6NXK3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

61622:LOC104668988
gene id: 61622:LOC104668988
uniprot id: A0A2K6PM53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

61622:TGFA
gene id: 61622:TGFA
uniprot id: A0A2K6RB90
uniprot id: A0A2K6RBD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RNGTT
gene id: 61622:RNGTT
uniprot id: A0A2K6PA00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

61622:ST18
gene id: 61622:ST18
uniprot id: A0A2K6NX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

61622:PLTP
gene id: 61622:PLTP
uniprot id: A0A2K6R8R3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

61622:SLC12A3
gene id: 61622:SLC12A3
uniprot id: A0A2K6QFK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:LOC104671878
gene id: 61622:LOC104671878
uniprot id: A0A2K6NXG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

61622:DUOXA1
gene id: 61622:DUOXA1
uniprot id: A0A2K6Q8V1
uniprot id: A0A2K6Q8V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

61622:UBE2T
gene id: 61622:UBE2T
uniprot id: A0A2K6QDU6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:ABCB5
gene id: 61622:ABCB5
uniprot id: A0A2K6NGD8
names: Subcellular Location Annotation
messages: Membrane

61622:C3
gene id: 61622:C3
uniprot id: A0A2K6RMX8
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

61622:PLG
gene id: 61622:PLG
uniprot id: A0A2K6RCW8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

61622:STX10
gene id: 61622:STX10
uniprot id: A0A2K6QZB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

61622:EID2
gene id: 61622:EID2
uniprot id: A0A2K6NE75
names: Subcellular Location Annotation
messages: Nucleus

61622:BMP1
gene id: 61622:BMP1
uniprot id: A0A2K6QKE0
uniprot id: A0A2K6QKE4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PIGU
gene id: 61622:PIGU
uniprot id: A0A2K6NZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NAB1
gene id: 61622:NAB1
uniprot id: A0A2K6PZ36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

61622:EVC2
gene id: 61622:EVC2
uniprot id: A0A2K6QBI4
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

61622:VXN
gene id: 61622:VXN
uniprot id: A0A2K6PI44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

61622:LOC104658976
gene id: 61622:LOC104658976
uniprot id: A0A2K6R6X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61622:PRMT7
gene id: 61622:PRMT7
uniprot id: A0A2K6PQN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

61622:USB1
gene id: 61622:USB1
uniprot id: A0A2K6NZ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

61622:OAS2
gene id: 61622:OAS2
uniprot id: A0A2K6R262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

61622:TFPI
gene id: 61622:TFPI
uniprot id: A0A2K6P8A1
uniprot id: A0A2K6P8B5
names: Subcellular Location Annotation
messages: Secreted

61622:SMG9
gene id: 61622:SMG9
uniprot id: A0A2K6P0Y1
uniprot id: A0A2K6P0Y3
names: Similarity
messages: Belongs to the SMG9 family.

61622:EMC8
gene id: 61622:EMC8
uniprot id: A0A2K6NVT4
uniprot id: A0A2K6NVT9
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

61622:EPGN
gene id: 61622:EPGN
uniprot id: A0A2K6PJK9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ARPC1B
gene id: 61622:ARPC1B
uniprot id: A0A2K6QQ53
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

61622:PKIB
gene id: 61622:PKIB
uniprot id: A0A2K6QHE7
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

61622:PRDM13
gene id: 61622:PRDM13
uniprot id: A0A2K6QDZ4
names: Subcellular Location Annotation
messages: Nucleus

61622:P2RX3
gene id: 61622:P2RX3
uniprot id: A0A2K6QPJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61622:HOPX
gene id: 61622:HOPX
uniprot id: A0A2K6P7Y0
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104658933
gene id: 61622:LOC104658933
uniprot id: A0A2K6NPR3
uniprot id: A0A2K6NPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

61622:RBBP7
gene id: 61622:RBBP7
uniprot id: A0A2K6R6Y3
names: Subcellular Location Annotation
messages: Nucleus

61622:IFNG
gene id: 61622:IFNG
uniprot id: A0A2K6PM05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

61622:MAF1
gene id: 61622:MAF1
uniprot id: A0A2K6RTI6
uniprot id: A0A2K6RTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

61622:PRKDC
gene id: 61622:PRKDC
uniprot id: A0A2K6RU40
uniprot id: A0A2K6RU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: nucleolus

61622:HCRT
gene id: 61622:HCRT
uniprot id: A0A2K6RAI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

61622:GNRHR
gene id: 61622:GNRHR
uniprot id: A0A2K6NG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GNAZ
gene id: 61622:GNAZ
uniprot id: A0A2K6NW28
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61622:KCNG4
gene id: 61622:KCNG4
uniprot id: A0A2K6PDW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TAS1R2
gene id: 61622:TAS1R2
uniprot id: A0A0M4PM72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TAMM41
gene id: 61622:TAMM41
uniprot id: A0A2K6PY25
uniprot id: A0A2K6PY36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

61622:WASF1
gene id: 61622:WASF1
uniprot id: A0A2K6NT85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

61622:XRCC4
gene id: 61622:XRCC4
uniprot id: A0A2K6P651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

61622:TRIM4
gene id: 61622:TRIM4
uniprot id: A0A2K6RL33
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:S100G
gene id: 61622:S100G
uniprot id: A0A2K6QJP6
names: Similarity
messages: Belongs to the S-100 family.

61622:HEBP1
gene id: 61622:HEBP1
uniprot id: A0A2K6PM04
names: Similarity
messages: Belongs to the HEBP family.

61622:CLTA
gene id: 61622:CLTA
uniprot id: A0A2K6P794
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

61622:GABRG3
gene id: 61622:GABRG3
uniprot id: A0A2K6R7J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:PTGES
gene id: 61622:PTGES
uniprot id: A0A2K6NSK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

61622:RECQL5
gene id: 61622:RECQL5
uniprot id: A0A2K6RG98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

61622:ALAD
gene id: 61622:ALAD
uniprot id: A0A2K6Q2Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

61622:MTMR6
gene id: 61622:MTMR6
uniprot id: A0A2K6P836
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61622:MYBBP1A
gene id: 61622:MYBBP1A
uniprot id: A0A2K6QSP4
names: Similarity
messages: Belongs to the MYBBP1A family.

61622:VPS29
gene id: 61622:VPS29
uniprot id: A0A2K6PSS4
uniprot id: A0A2K6PSS9
uniprot id: A0A2K6PST2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

61622:CXCL13
gene id: 61622:CXCL13
uniprot id: A0A2K6RD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:TPO
gene id: 61622:TPO
uniprot id: A0A2K6RM99
uniprot id: A0A2K6RMA2
uniprot id: A0A2K6RMA5
uniprot id: A0A2K6RMB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Interacts with DUOX1, DUOX2 and CYBA.
messages: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FGB
gene id: 61622:FGB
uniprot id: A0A2K6REZ3
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

61622:LOC104672362
gene id: 61622:LOC104672362
uniprot id: A0A2K6NHC6
names: Similarity
messages: Belongs to the ubiquitin family.

61622:TUBGCP4
gene id: 61622:TUBGCP4
uniprot id: A0A2K6QVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61622:MARF1
gene id: 61622:MARF1
uniprot id: A0A2K6N963
names: Subcellular Location Annotation
messages: Peroxisome

61622:EXTL3
gene id: 61622:EXTL3
uniprot id: A0A2K6QHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:C3H5orf22
gene id: 61622:C3H5orf22
uniprot id: A0A2K6NZ10
names: Similarity
messages: Belongs to the UPF0489 family.

61622:TBL3
gene id: 61622:TBL3
uniprot id: A0A2K6NRQ5
names: Subcellular Location Annotation
messages: nucleolus

61622:AOC3
gene id: 61622:AOC3
uniprot id: A0A2K6P0A3
uniprot id: A0A2K6P0A5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

61622:MRPS18B
gene id: 61622:MRPS18B
uniprot id: A0A2K6NJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

61622:SLC22A5
gene id: 61622:SLC22A5
uniprot id: A0A2K6Q591
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Interacts with PDZK1.

61622:ADGRD1
gene id: 61622:ADGRD1
uniprot id: A0A2K6Q534
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TRIT1
gene id: 61622:TRIT1
uniprot id: A0A2K6RC58
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

61622:SLC12A9
gene id: 61622:SLC12A9
uniprot id: A0A2K6NZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:FMO1
gene id: 61622:FMO1
uniprot id: A0A2K6RMJ0
uniprot id: A0A2K6RMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PIGB
gene id: 61622:PIGB
uniprot id: A0A2K6RD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:HMX1
gene id: 61622:HMX1
uniprot id: A0A2K6RVX6
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC6A15
gene id: 61622:SLC6A15
uniprot id: A0A2K6Q496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

61622:FKRP
gene id: 61622:FKRP
uniprot id: A0A2K6NC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

61622:STX7
gene id: 61622:STX7
uniprot id: A0A2K6NZI5
names: Similarity
messages: Belongs to the syntaxin family.

61622:CNTFR
gene id: 61622:CNTFR
uniprot id: A0A2K6RJC0
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

61622:LOC104653583
gene id: 61622:LOC104653583
uniprot id: A0A2K6QVQ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:VTI1A
gene id: 61622:VTI1A
uniprot id: A0A2K6PX38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

61622:DCST2
gene id: 61622:DCST2
uniprot id: A0A2K6NB47
names: Subcellular Location Annotation
messages: Membrane

61622:NCF2
gene id: 61622:NCF2
uniprot id: A0A2K6RL28
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

61622:BPGM
gene id: 61622:BPGM
uniprot id: A0A2K6QUE4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:PF4
gene id: 61622:PF4
uniprot id: A0A2K6PHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:ETNPPL
gene id: 61622:ETNPPL
uniprot id: A0A2K6NYV1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61622:SLC25A14
gene id: 61622:SLC25A14
uniprot id: A0A2K6QR83
uniprot id: A0A2K6QR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:RSPO4
gene id: 61622:RSPO4
uniprot id: A0A2K6Q1X1
names: Similarity
messages: Belongs to the R-spondin family.

61622:NUDT12
gene id: 61622:NUDT12
uniprot id: A0A2K6R147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

61622:SP4
gene id: 61622:SP4
uniprot id: A0A2K6PLE9
names: Subcellular Location Annotation
messages: Nucleus

61622:ELOC
gene id: 61622:ELOC
uniprot id: A0A2K6PBR9
names: Similarity
messages: Belongs to the SKP1 family.

61622:SLC4A4
gene id: 61622:SLC4A4
uniprot id: A0A2K6Q683
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

61622:E2F3
gene id: 61622:E2F3
uniprot id: A0A2K6NHM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:CLIC3
gene id: 61622:CLIC3
uniprot id: A0A2K6RD11
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:PLAU
gene id: 61622:PLAU
uniprot id: A0A2K6P8X0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DKK1
gene id: 61622:DKK1
uniprot id: A0A2K6QDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

61622:TMEM41A
gene id: 61622:TMEM41A
uniprot id: A0A2K6NRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

61622:CNRIP1
gene id: 61622:CNRIP1
uniprot id: A0A2K6PQS5
uniprot id: A0A2K6PQT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

61622:KREMEN2
gene id: 61622:KREMEN2
uniprot id: A0A2K6RFJ2
uniprot id: A0A2K6RFN1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

61622:ANAPC4
gene id: 61622:ANAPC4
uniprot id: A0A2K6PHC8
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

61622:NKD1
gene id: 61622:NKD1
uniprot id: A0A2K6PJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

61622:ARHGDIG
gene id: 61622:ARHGDIG
uniprot id: A0A2K6Q216
names: Similarity
messages: Belongs to the Rho GDI family.

61622:VEGFB
gene id: 61622:VEGFB
uniprot id: A0A2K6N7D2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

61622:MMP1
gene id: 61622:MMP1
uniprot id: A0A2K6P8D9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:CDK7
gene id: 61622:CDK7
uniprot id: A0A2K6QZC6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

61622:AVPR1A
gene id: 61622:AVPR1A
uniprot id: A0A2K6QML0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

61622:LHX6
gene id: 61622:LHX6
uniprot id: A0A2K6NST8
uniprot id: A0A2K6NSU5
names: Subcellular Location Annotation
messages: Nucleus

61622:PRPF4B
gene id: 61622:PRPF4B
uniprot id: A0A2K6RFJ3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

61622:DVL3
gene id: 61622:DVL3
uniprot id: A0A2K6PVY9
names: Similarity
messages: Belongs to the DSH family.

61622:TRAK2
gene id: 61622:TRAK2
uniprot id: A0A2K6QPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

61622:NR1H4
gene id: 61622:NR1H4
uniprot id: A0A2K6QXV7
uniprot id: A0A2K6QXW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:MOK
gene id: 61622:MOK
uniprot id: A0A2K6RST0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LHX9
gene id: 61622:LHX9
uniprot id: A0A2K6R194
names: Subcellular Location Annotation
messages: Nucleus

61622:TOMM20L
gene id: 61622:TOMM20L
uniprot id: A0A2K6QVT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:SLC31A1
gene id: 61622:SLC31A1
uniprot id: A0A2K6P9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:PARP12
gene id: 61622:PARP12
uniprot id: A0A2K6Q8X9
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:MEP1A
gene id: 61622:MEP1A
uniprot id: A0A2K6PCS7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NBR1
gene id: 61622:NBR1
uniprot id: A0A2K6PV97
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

61622:LOC104680420
gene id: 61622:LOC104680420
uniprot id: A0A2K6PQ65
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61622:MAL
gene id: 61622:MAL
uniprot id: A0A2K6Q152
names: Subcellular Location Annotation
messages: Membrane

61622:SNAP25
gene id: 61622:SNAP25
uniprot id: A0A2K6R755
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

61622:AVPR2
gene id: 61622:AVPR2
uniprot id: A0A2K6Q9U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

61622:IVD
gene id: 61622:IVD
uniprot id: A0A2K6NB55
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:LSM3
gene id: 61622:LSM3
uniprot id: A0A2K6PPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

61622:FCN1
gene id: 61622:FCN1
uniprot id: A0A2K6QMA6
names: Similarity
messages: Belongs to the ficolin lectin family.

61622:KCNC1
gene id: 61622:KCNC1
uniprot id: A0A2K6NQS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:GIMAP2
gene id: 61622:GIMAP2
uniprot id: A0A2K6QAI8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61622:THYN1
gene id: 61622:THYN1
uniprot id: A0A2K6P0R5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

61622:CDIPT
gene id: 61622:CDIPT
uniprot id: A0A2K6P2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

61622:LHPP
gene id: 61622:LHPP
uniprot id: A0A2K6RCM6
uniprot id: A0A2K6RCP6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

61622:OLFM1
gene id: 61622:OLFM1
uniprot id: A0A2K6Q7W9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:NAA40
gene id: 61622:NAA40
uniprot id: A0A2K6QYW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

61622:SS18L2
gene id: 61622:SS18L2
uniprot id: A0A2K6R2H9
names: Similarity
messages: Belongs to the SS18 family.

61622:CHRM4
gene id: 61622:CHRM4
uniprot id: A0A2K6NNT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

61622:FTL
gene id: 61622:FTL
uniprot id: A0A2K6R7Z7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:LOC104661958
gene id: 61622:LOC104661958
uniprot id: A0A2K6NL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

61622:NXPH2
gene id: 61622:NXPH2
uniprot id: A0A2K6NWS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61622:PDE8A
gene id: 61622:PDE8A
uniprot id: A0A2K6PBG7
uniprot id: A0A2K6PBJ7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:INA
gene id: 61622:INA
uniprot id: A0A2K6RRL0
names: Similarity
messages: Belongs to the intermediate filament family.

61622:RBBP8
gene id: 61622:RBBP8
uniprot id: A0A2K6NEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

61622:AP1M2
gene id: 61622:AP1M2
uniprot id: A0A2K6QBT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

61622:FAM110C
gene id: 61622:FAM110C
uniprot id: A0A2K6QVC1
names: Similarity
messages: Belongs to the FAM110 family.

61622:MPP1
gene id: 61622:MPP1
uniprot id: A0A2K6PNM8
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

61622:RFC4
gene id: 61622:RFC4
uniprot id: A0A2K6P845
names: Similarity
messages: Belongs to the activator 1 small subunits family.

61622:HPS5
gene id: 61622:HPS5
uniprot id: A0A2K6RW53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

61622:BARHL1
gene id: 61622:BARHL1
uniprot id: A0A2K6P349
names: Subcellular Location Annotation
messages: Nucleus

61622:BCCIP
gene id: 61622:BCCIP
uniprot id: A0A2K6PBQ2
uniprot id: A0A2K6PBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

61622:A4GNT
gene id: 61622:A4GNT
uniprot id: A0A2K6QYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

61622:FIP1L1
gene id: 61622:FIP1L1
uniprot id: A0A2K6RS97
uniprot id: A0A2K6RSA3
uniprot id: A0A2K6RSA7
uniprot id: A0A2K6RSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

61622:LOC104661761
gene id: 61622:LOC104661761
uniprot id: A0A2K6NSK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61622:MYO1E
gene id: 61622:MYO1E
uniprot id: A0A2K6PT66
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:MAEL
gene id: 61622:MAEL
uniprot id: A0A2K6QRB9
uniprot id: A0A2K6QRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

61622:BZW1
gene id: 61622:BZW1
uniprot id: A0A2K6RMR8
names: Similarity
messages: Belongs to the BZW family.

61622:INPP5J
gene id: 61622:INPP5J
uniprot id: A0A2K6PII5
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

61622:NOS3
gene id: 61622:NOS3
uniprot id: A0A2K6PX93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

61622:SUGCT
gene id: 61622:SUGCT
uniprot id: A0A2K6PPZ7
uniprot id: A0A2K6PQ06
names: Similarity
messages: Belongs to the CoA-transferase III family.

61622:LOC104663768
gene id: 61622:LOC104663768
uniprot id: A0A2K6Q016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:DNPH1
gene id: 61622:DNPH1
uniprot id: A0A2K6NFY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

61622:MRPL2
gene id: 61622:MRPL2
uniprot id: A0A2K6PJ70
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

61622:C9H8orf37
gene id: 61622:C9H8orf37
uniprot id: A0A2K6PMV5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

61622:LOC104664028
gene id: 61622:LOC104664028
uniprot id: A0A2K6R6E7
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:PTH2R
gene id: 61622:PTH2R
uniprot id: A0A2K6QKB6
names: Subcellular Location Annotation
messages: Membrane

61622:TMEM186
gene id: 61622:TMEM186
uniprot id: A0A2K6RBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

61622:NUPR1
gene id: 61622:NUPR1
uniprot id: A0A2K6QSW0
names: Similarity
messages: Belongs to the NUPR family.

61622:MRS2
gene id: 61622:MRS2
uniprot id: A0A2K6RP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

61622:PCMT1
gene id: 61622:PCMT1
uniprot id: A0A2K6R8P6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:SLC12A8
gene id: 61622:SLC12A8
uniprot id: A0A2K6RVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:EEF1A1
gene id: 61622:EEF1A1
uniprot id: A0A2K6RQ54
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:NDEL1
gene id: 61622:NDEL1
uniprot id: A0A2K6QX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

61622:CAV2
gene id: 61622:CAV2
uniprot id: A0A2K6PZC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

61622:ARSJ
gene id: 61622:ARSJ
uniprot id: A0A2K6Q414
names: Similarity
messages: Belongs to the sulfatase family.

61622:CDK4
gene id: 61622:CDK4
uniprot id: A0A2K6P415
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GNB5
gene id: 61622:GNB5
uniprot id: A0A2K6QRR3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

61622:PXMP2
gene id: 61622:PXMP2
uniprot id: A0A2K6NPT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61622:CD79A
gene id: 61622:CD79A
uniprot id: A0A2K6QQG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:C7HXorf56
gene id: 61622:C7HXorf56
uniprot id: A0A2K6PG11
names: Similarity
messages: Belongs to the STEEP1 family.

61622:RECQL
gene id: 61622:RECQL
uniprot id: A0A2K6NE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

61622:LGI4
gene id: 61622:LGI4
uniprot id: A0A2K6PRQ4
names: Subcellular Location Annotation
messages: Secreted

61622:ATP6V1G2
gene id: 61622:ATP6V1G2
uniprot id: A0A2K6NFE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:YDJC
gene id: 61622:YDJC
uniprot id: A0A2K6NC04
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

61622:INHBC
gene id: 61622:INHBC
uniprot id: A0A2K6R770
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

61622:DPH6
gene id: 61622:DPH6
uniprot id: A0A2K6QJV5
uniprot id: A0A2K6QJW8
names: Similarity
messages: Belongs to the Diphthine--ammonia ligase family.

61622:LOC104679364
gene id: 61622:LOC104679364
uniprot id: A0A2K6QAP0
names: Subcellular Location Annotation
messages: Secreted

61622:PTHLH
gene id: 61622:PTHLH
uniprot id: A0A2K6Q2L0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

61622:CAV3
gene id: 61622:CAV3
uniprot id: A0A2K6NIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

61622:SLC17A2
gene id: 61622:SLC17A2
uniprot id: A0A2K6PRR5
uniprot id: A0A2K6PRT1
names: Subcellular Location Annotation
messages: Membrane

61622:ANXA5
gene id: 61622:ANXA5
uniprot id: A0A2K6PH14
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

61622:MAGOHB
gene id: 61622:MAGOHB
uniprot id: A0A2K6QP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

61622:APTX
gene id: 61622:APTX
uniprot id: A0A2K6Q2U0
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

61622:SEC61A1
gene id: 61622:SEC61A1
uniprot id: A0A2K6RM95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PLXNA4
gene id: 61622:PLXNA4
uniprot id: A0A2K6NA59
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NAE1
gene id: 61622:NAE1
uniprot id: A0A2K6Q410
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

61622:GANAB
gene id: 61622:GANAB
uniprot id: A0A2K6QE81
uniprot id: A0A2K6QE85
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

61622:AFG3L2
gene id: 61622:AFG3L2
uniprot id: A0A2K6QHN1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

61622:GSDME
gene id: 61622:GSDME
uniprot id: A0A2K6QID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61622:NKX2-8
gene id: 61622:NKX2-8
uniprot id: A0A2K6PLA5
names: Subcellular Location Annotation
messages: Nucleus

61622:TEAD2
gene id: 61622:TEAD2
uniprot id: A0A2K6QTV5
uniprot id: A0A2K6QTX9
names: Subcellular Location Annotation
messages: Nucleus

61622:GPBP1
gene id: 61622:GPBP1
uniprot id: A0A2K6PKS6
uniprot id: A0A2K6PL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

61622:ADIPOR1
gene id: 61622:ADIPOR1
uniprot id: A0A2K6PJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:EIF3A
gene id: 61622:EIF3A
uniprot id: A0A2K6RV18
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

61622:DGKG
gene id: 61622:DGKG
uniprot id: A0A2K6PTT0
uniprot id: A0A2K6PTU1
uniprot id: A0A2K6PTU3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61622:FNIP2
gene id: 61622:FNIP2
uniprot id: A0A2K6NHA8
uniprot id: A0A2K6NHB3
uniprot id: A0A2K6NHD3
uniprot id: A0A2K6NHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

61622:ITIH5
gene id: 61622:ITIH5
uniprot id: A0A2K6PX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:RPS29
gene id: 61622:RPS29
uniprot id: A0A2K6QDH5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

61622:SLC17A6
gene id: 61622:SLC17A6
uniprot id: A0A2K6NS20
names: Subcellular Location Annotation
messages: Membrane

61622:ONECUT1
gene id: 61622:ONECUT1
uniprot id: A0A2K6PMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:SSX2IP
gene id: 61622:SSX2IP
uniprot id: A0A2K6RFT0
uniprot id: A0A2K6RFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

61622:CLCN6
gene id: 61622:CLCN6
uniprot id: A0A2K6PD67
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:MS4A2
gene id: 61622:MS4A2
uniprot id: A0A2K6QZK0
names: Similarity
messages: Belongs to the MS4A family.

61622:UBAC2
gene id: 61622:UBAC2
uniprot id: A0A2K6R293
names: Subcellular Location Annotation
messages: Membrane

61622:KRT36
gene id: 61622:KRT36
uniprot id: A0A2K6Q1A4
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PLPP3
gene id: 61622:PLPP3
uniprot id: A0A2K6RF46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:USP30
gene id: 61622:USP30
uniprot id: A0A2K6RVV2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:OTOA
gene id: 61622:OTOA
uniprot id: A0A2K6PNL0
names: Similarity
messages: Belongs to the mesothelin family.

61622:MRE11
gene id: 61622:MRE11
uniprot id: A0A2K6QZ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

61622:DAG1
gene id: 61622:DAG1
uniprot id: A0A2K6RBL8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

61622:LOC104657699
gene id: 61622:LOC104657699
uniprot id: A0A2K6NGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SLC22A2
gene id: 61622:SLC22A2
uniprot id: A0A2K6QJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

61622:TPPP2
gene id: 61622:TPPP2
uniprot id: A0A2K6NME1
names: Similarity
messages: Belongs to the TPPP family.

61622:DYNC2LI1
gene id: 61622:DYNC2LI1
uniprot id: A0A2K6Q6I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

61622:SMARCAD1
gene id: 61622:SMARCAD1
uniprot id: A0A2K6Q2E3
names: Subcellular Location Annotation
messages: Chromosome

61622:CD27
gene id: 61622:CD27
uniprot id: A0A2K6P7F3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CLDN10
gene id: 61622:CLDN10
uniprot id: A0A2K6PZD4
uniprot id: A0A2K6PZE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:MED30
gene id: 61622:MED30
uniprot id: A0A2K6P151
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

61622:TMEM33
gene id: 61622:TMEM33
uniprot id: A0A2K6NFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

61622:NKX6-3
gene id: 61622:NKX6-3
uniprot id: A0A2K6NSQ1
names: Subcellular Location Annotation
messages: Nucleus

61622:QRSL1
gene id: 61622:QRSL1
uniprot id: A0A2K6PIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

61622:ASB11
gene id: 61622:ASB11
uniprot id: A0A2K6RGG1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:PRLHR
gene id: 61622:PRLHR
uniprot id: A0A2K6NPT3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:CASP4
gene id: 61622:CASP4
uniprot id: A0A2K6Q2V4
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:GDF15
gene id: 61622:GDF15
uniprot id: A0A2K6PFL0
names: Similarity
messages: Belongs to the TGF-beta family.

61622:LDAH
gene id: 61622:LDAH
uniprot id: A0A2K6RDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

61622:TGFB1I1
gene id: 61622:TGFB1I1
uniprot id: A0A2K6QE13
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Nucleus matrix
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: cytoskeleton
messages: focal adhesion

61622:MRPL3
gene id: 61622:MRPL3
uniprot id: A0A2K6QXZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

61622:DGKZ
gene id: 61622:DGKZ
uniprot id: A0A2K6RMD0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61622:MPG
gene id: 61622:MPG
uniprot id: A0A2K6QDE9
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

61622:CRP
gene id: 61622:CRP
uniprot id: A0A2K6RS55
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:MIOX
gene id: 61622:MIOX
uniprot id: A0A2K6Q3J2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

61622:SNAPIN
gene id: 61622:SNAPIN
uniprot id: A0A2K6N6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

61622:TPM2
gene id: 61622:TPM2
uniprot id: A0A2K6R4X7
uniprot id: A0A2K6R4Y0
uniprot id: A0A2K6R4Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:PLD3
gene id: 61622:PLD3
uniprot id: A0A2K6R3J4
names: Similarity
messages: Belongs to the phospholipase D family.

61622:CREM
gene id: 61622:CREM
uniprot id: A0A2K6P2F7
uniprot id: A0A2K6P2H0
names: Subcellular Location Annotation
messages: Nucleus

61622:SKA2
gene id: 61622:SKA2
uniprot id: A0A2K6P7G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

61622:FTHL17
gene id: 61622:FTHL17
uniprot id: A0A2K6QFJ2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:CCNT2
gene id: 61622:CCNT2
uniprot id: A0A2K6QLN5
uniprot id: A0A2K6QLP9
names: Similarity
messages: Belongs to the cyclin family.

61622:C20H16orf72
gene id: 61622:C20H16orf72
uniprot id: A0A2K6QI54
names: Subcellular Location Annotation
messages: Nucleus

61622:CAND1
gene id: 61622:CAND1
uniprot id: A0A2K6NYI0
names: Similarity
messages: Belongs to the CAND family.

61622:ACADL
gene id: 61622:ACADL
uniprot id: A0A2K6NC90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

61622:SEMA3G
gene id: 61622:SEMA3G
uniprot id: A0A2K6P1K8
uniprot id: A0A2K6P1L2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TGFBI
gene id: 61622:TGFBI
uniprot id: A0A2K6QJF0
names: Subcellular Location Annotation
messages: extracellular matrix

61622:PKIG
gene id: 61622:PKIG
uniprot id: A0A2K6P059
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

61622:UBE2H
gene id: 61622:UBE2H
uniprot id: A0A2K6QNK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:ELOVL6
gene id: 61622:ELOVL6
uniprot id: A0A2K6RTD7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

61622:E2F2
gene id: 61622:E2F2
uniprot id: A0A2K6P1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:TP63
gene id: 61622:TP63
uniprot id: A0A2K6NHJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Nucleus

61622:ITGA6
gene id: 61622:ITGA6
uniprot id: A0A2K6Q8D5
uniprot id: A0A2K6Q8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:NT5C3B
gene id: 61622:NT5C3B
uniprot id: A0A2K6RCU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

61622:DMC1
gene id: 61622:DMC1
uniprot id: A0A2K6REC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

61622:APEH
gene id: 61622:APEH
uniprot id: A0A2K6NAC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

61622:GTF2E1
gene id: 61622:GTF2E1
uniprot id: A0A2K6NN34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIE alpha subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

61622:CALY
gene id: 61622:CALY
uniprot id: A0A2K6Q7V0
names: Similarity
messages: Belongs to the NSG family.

61622:AQP1
gene id: 61622:AQP1
uniprot id: A0A2K6N818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:GLB1L3
gene id: 61622:GLB1L3
uniprot id: A0A2K6RK25
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

61622:EPCAM
gene id: 61622:EPCAM
uniprot id: A0A2K6NB45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

61622:RELL2
gene id: 61622:RELL2
uniprot id: A0A2K6PCF1
names: Similarity
messages: Belongs to the RELT family.

61622:ADAMTS18
gene id: 61622:ADAMTS18
uniprot id: A0A2K6P3T5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:KEG34 p03
gene id: 61622:KEG34_p03
uniprot id: Q15GN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SIVA1
gene id: 61622:SIVA1
uniprot id: A0A2K6P267
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

61622:ORC3
gene id: 61622:ORC3
uniprot id: A0A2K6QJ44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

61622:LIF
gene id: 61622:LIF
uniprot id: A0A2K6N7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

61622:ABCG1
gene id: 61622:ABCG1
uniprot id: A0A2K6RWC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61622:LOC104662043
gene id: 61622:LOC104662043
uniprot id: A0A2K6NCQ3
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:SLC46A3
gene id: 61622:SLC46A3
uniprot id: A0A2K6NGE2
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104664240
gene id: 61622:LOC104664240
uniprot id: A0A2K6NNY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61622:DRGX
gene id: 61622:DRGX
uniprot id: A0A2K6Q8V3
names: Subcellular Location Annotation
messages: Nucleus

61622:TSPAN19
gene id: 61622:TSPAN19
uniprot id: A0A2K6QEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:NIPAL2
gene id: 61622:NIPAL2
uniprot id: A0A2K6NB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61622:ABI1
gene id: 61622:ABI1
uniprot id: A0A2K6NYW6
uniprot id: A0A2K6NYW8
uniprot id: A0A2K6NYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

61622:DGKA
gene id: 61622:DGKA
uniprot id: A0A2K6NNS7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

61622:LOC104658369
gene id: 61622:LOC104658369
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:ODAM
gene id: 61622:ODAM
uniprot id: A0A2K6P694
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

61622:B4GALNT2
gene id: 61622:B4GALNT2
uniprot id: A0A2K6N834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

61622:GPR18
gene id: 61622:GPR18
uniprot id: A0A2K6NE95
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:LOC104669726
gene id: 61622:LOC104669726
uniprot id: A0A2K6R448
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
messages: Mitochondrion inner membrane

61622:ADCY2
gene id: 61622:ADCY2
uniprot id: A0A2K6P7N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

61622:LOC104667986
gene id: 61622:LOC104667986
uniprot id: A0A2K6QHU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

61622:ERMP1
gene id: 61622:ERMP1
uniprot id: A0A2K6PPH4
names: Subcellular Location Annotation
messages: Membrane

61622:DNAJC16
gene id: 61622:DNAJC16
uniprot id: A0A2K6NLS2
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

61622:EGR3
gene id: 61622:EGR3
uniprot id: A0A2K6QNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

61622:BNIP1
gene id: 61622:BNIP1
uniprot id: A0A2K6Q104
names: Subcellular Location Annotation
messages: Membrane

61622:RPL26
gene id: 61622:RPL26
uniprot id: A0A2K6NS74
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:RHOT2
gene id: 61622:RHOT2
uniprot id: A0A2K6ND64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

61622:DHODH
gene id: 61622:DHODH
uniprot id: A0A2K6REV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

61622:SMIM22
gene id: 61622:SMIM22
uniprot id: A0A2K6NZ59
names: Subcellular Location Annotation
messages: Membrane

61622:ATL1
gene id: 61622:ATL1
uniprot id: A0A2K6NCX1
uniprot id: A0A2K6NCX8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:GLRA1
gene id: 61622:GLRA1
uniprot id: A0A2K6NHU4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

61622:QTRT2
gene id: 61622:QTRT2
uniprot id: A0A2K6PXH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

61622:PLA2G2E
gene id: 61622:PLA2G2E
uniprot id: A0A2K6RVT4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:CCL17
gene id: 61622:CCL17
uniprot id: A0A2K6PBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:GAP43
gene id: 61622:GAP43
uniprot id: A0A2K6P5I2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

61622:INSIG2
gene id: 61622:INSIG2
uniprot id: A0A2K6NJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

61622:FSD2
gene id: 61622:FSD2
uniprot id: A0A2K6R9P6
names: Subcellular Location Annotation
messages: Cytoplasm

61622:GRAMD1C
gene id: 61622:GRAMD1C
uniprot id: A0A2K6R420
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:HS3ST2
gene id: 61622:HS3ST2
uniprot id: A0A2K6NVJ3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:ABCC6
gene id: 61622:ABCC6
uniprot id: A0A2K6Q7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:FMO3
gene id: 61622:FMO3
uniprot id: A0A2K6N8Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

61622:PICALM
gene id: 61622:PICALM
uniprot id: A0A2K6RDT3
uniprot id: A0A2K6RDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

61622:C12H1orf158
gene id: 61622:C12H1orf158
uniprot id: A0A2K6Q3I3
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

61622:POU4F2
gene id: 61622:POU4F2
uniprot id: A0A2K6QVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61622:HSP90AB1
gene id: 61622:HSP90AB1
uniprot id: A0A2K6RR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

61622:NT5DC1
gene id: 61622:NT5DC1
uniprot id: A0A2K6PK93
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

61622:AQP11
gene id: 61622:AQP11
uniprot id: A0A2K6RLD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

61622:CC2D1B
gene id: 61622:CC2D1B
uniprot id: A0A2K6NEF6
names: Similarity
messages: Belongs to the CC2D1 family.

61622:PRKD2
gene id: 61622:PRKD2
uniprot id: A0A2K6Q042
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

61622:CLDN17
gene id: 61622:CLDN17
uniprot id: A0A2K6NQW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:MAP4K3
gene id: 61622:MAP4K3
uniprot id: A0A2K6RG27
uniprot id: A0A2K6RG49
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

61622:TDRD5
gene id: 61622:TDRD5
uniprot id: A0A2K6RV66
uniprot id: A0A2K6RV77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

61622:TMEM167B
gene id: 61622:TMEM167B
uniprot id: A0A2K6RN13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TFEB
gene id: 61622:TFEB
uniprot id: A0A2K6R648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61622:PMPCB
gene id: 61622:PMPCB
uniprot id: A0A2K6NT14
uniprot id: A0A2K6NT15
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:LMOD3
gene id: 61622:LMOD3
uniprot id: A0A2K6PKW2
names: Subcellular Location Annotation
messages: cytoskeleton

61622:CRYBB1
gene id: 61622:CRYBB1
uniprot id: A0A2K6RIG0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:RND3
gene id: 61622:RND3
uniprot id: A0A2K6NQK9
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

61622:CCNDBP1
gene id: 61622:CCNDBP1
uniprot id: A0A2K6QPE0
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

61622:TYMS
gene id: 61622:TYMS
uniprot id: A0A2K6PR41
names: Similarity
messages: Belongs to the thymidylate synthase family.

61622:FAM133B
gene id: 61622:FAM133B
uniprot id: A0A2K6RHZ8
names: Similarity
messages: Belongs to the FAM133 family.

61622:ITGB7
gene id: 61622:ITGB7
uniprot id: A0A2K6NX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

61622:HSF2
gene id: 61622:HSF2
uniprot id: A0A2K6QGR1
uniprot id: A0A2K6QGR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:B4GAT1
gene id: 61622:B4GAT1
uniprot id: A0A2K6PD90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:TCTEX1D2
gene id: 61622:TCTEX1D2
uniprot id: A0A2K6Q9W3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:CNFN
gene id: 61622:CNFN
uniprot id: A0A2K6PW70
names: Similarity
messages: Belongs to the cornifelin family.

61622:ASXL2
gene id: 61622:ASXL2
uniprot id: A0A2K6PX85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

61622:RNF141
gene id: 61622:RNF141
uniprot id: A0A2K6NF33
names: Function
messages: May be involved in spermatogenesis.

61622:DSG1
gene id: 61622:DSG1
uniprot id: A0A2K6NA25
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:GUCY1B1
gene id: 61622:GUCY1B1
uniprot id: A0A2K6QJ78
uniprot id: A0A2K6QJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

61622:SLC25A44
gene id: 61622:SLC25A44
uniprot id: A0A2K6P5D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:MAOB
gene id: 61622:MAOB
uniprot id: A0A2K6R307
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61622:ERG28
gene id: 61622:ERG28
uniprot id: A0A2K6RJL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TSPAN31
gene id: 61622:TSPAN31
uniprot id: A0A2K6NX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:TMEM200A
gene id: 61622:TMEM200A
uniprot id: A0A2K6NFQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

61622:MTNR1B
gene id: 61622:MTNR1B
uniprot id: A0A2K6NIS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ARHGAP26
gene id: 61622:ARHGAP26
uniprot id: A0A2K6RE70
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

61622:FAM98A
gene id: 61622:FAM98A
uniprot id: A0A2K6QH79
names: Similarity
messages: Belongs to the FAM98 family.

61622:EBAG9
gene id: 61622:EBAG9
uniprot id: A0A2K6NM72
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

61622:LOC104659818
gene id: 61622:LOC104659818
uniprot id: A0A2K6NTV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61622:LPCAT3
gene id: 61622:LPCAT3
uniprot id: A0A2K6PQE3
names: Subcellular Location Annotation
messages: Membrane

61622:MYC
gene id: 61622:MYC
uniprot id: A0A2K6PIE5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: nucleolus
messages: nucleoplasm

61622:LOC115891968
gene id: 61622:LOC115891968
uniprot id: A0A2K6P327
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61622:LAMTOR4
gene id: 61622:LAMTOR4
uniprot id: A0A2K6RVX8
names: Similarity
messages: Belongs to the LAMTOR4 family.

61622:SLC9A5
gene id: 61622:SLC9A5
uniprot id: A0A2K6RTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

61622:GPD1L
gene id: 61622:GPD1L
uniprot id: A0A2K6PL61
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

61622:EPHA3
gene id: 61622:EPHA3
uniprot id: A0A2K6RAC4
names: Subcellular Location Annotation
messages: Membrane

61622:GFRA1
gene id: 61622:GFRA1
uniprot id: A0A2K6P5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

61622:AMDHD1
gene id: 61622:AMDHD1
uniprot id: A0A2K6NXQ4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

61622:LOC104653722
gene id: 61622:LOC104653722
uniprot id: A0A2K6QIS6
uniprot id: A0A2K6QIT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

61622:RSRP1
gene id: 61622:RSRP1
uniprot id: A0A2K6QGC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSRP family.
messages: Nucleus
messages: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.

61622:LOC104654534
gene id: 61622:LOC104654534
uniprot id: A0A2K6NL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:TNFAIP2
gene id: 61622:TNFAIP2
uniprot id: A0A2K6QPF3
names: Similarity
messages: Belongs to the SEC6 family.

61622:RPL23
gene id: 61622:RPL23
uniprot id: A0A2K6P6C4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

61622:NHP2
gene id: 61622:NHP2
uniprot id: A0A2K6RGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

61622:KCTD6
gene id: 61622:KCTD6
uniprot id: A0A2K6Q3N9
names: Subcellular Location Annotation
messages: Cell membrane

61622:MFSD11
gene id: 61622:MFSD11
uniprot id: A0A2K6QV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

61622:DPT
gene id: 61622:DPT
uniprot id: A0A2K6QR97
names: Similarity
messages: Belongs to the dermatopontin family.

61622:LSM14A
gene id: 61622:LSM14A
uniprot id: A0A2K6QGD8
uniprot id: A0A2K6QGD9
names: Similarity
messages: Belongs to the LSM14 family.

61622:PERP
gene id: 61622:PERP
uniprot id: A0A2K6PZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

61622:KCTD21
gene id: 61622:KCTD21
uniprot id: A0A2K6NHY8
names: Subcellular Location Annotation
messages: Cell membrane

61622:ADCYAP1R1
gene id: 61622:ADCYAP1R1
uniprot id: A0A2K6QPB5
uniprot id: A0A2K6QPB9
uniprot id: A0A2K6QPC2
names: Subcellular Location Annotation
messages: Membrane

61622:PDGFRL
gene id: 61622:PDGFRL
uniprot id: A0A2K6PI79
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

61622:GUK1
gene id: 61622:GUK1
uniprot id: A0A2K6PGH4
names: Similarity
messages: Belongs to the guanylate kinase family.

61622:PNLIPRP3
gene id: 61622:PNLIPRP3
uniprot id: A0A2K6R4R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61622:ENO4
gene id: 61622:ENO4
uniprot id: A0A2K6PZY2
names: Similarity
messages: Belongs to the enolase family.

61622:DDX17
gene id: 61622:DDX17
uniprot id: A0A2K6RV47
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:MAPK3
gene id: 61622:MAPK3
uniprot id: A0A2K6QTM1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

61622:PTAR1
gene id: 61622:PTAR1
uniprot id: A0A2K6QZ13
uniprot id: A0A2K6QZ46
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

61622:LOC104671077
gene id: 61622:LOC104671077
uniprot id: A0A2K6PY35
names: Subcellular Location Annotation
messages: Nucleus

61622:NKX2-6
gene id: 61622:NKX2-6
uniprot id: A0A2K6R6J5
names: Subcellular Location Annotation
messages: Nucleus

61622:KLHL40
gene id: 61622:KLHL40
uniprot id: A0A2K6R3L1
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

61622:MYO1F
gene id: 61622:MYO1F
uniprot id: A0A2K6R0P4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:PAQR3
gene id: 61622:PAQR3
uniprot id: A0A2K6NBN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:ARSI
gene id: 61622:ARSI
uniprot id: A0A2K6RFA4
names: Similarity
messages: Belongs to the sulfatase family.

61622:BRF2
gene id: 61622:BRF2
uniprot id: A0A2K6NWZ8
names: Subcellular Location Annotation
messages: Nucleus

61622:MAN1B1
gene id: 61622:MAN1B1
uniprot id: A0A2K6RP46
uniprot id: A0A2K6RP57
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:LOC104666251
gene id: 61622:LOC104666251
uniprot id: A0A2K6P346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:VGLL4
gene id: 61622:VGLL4
uniprot id: A0A2K6PLT0
uniprot id: A0A2K6PLU5
uniprot id: A0A2K6PLY8
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

61622:MRPL58
gene id: 61622:MRPL58
uniprot id: A0A2K6NEG6
names: Subcellular Location Annotation
messages: Mitochondrion

61622:PTPN22
gene id: 61622:PTPN22
uniprot id: A0A2K6P6G8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

61622:PARVA
gene id: 61622:PARVA
uniprot id: A0A2K6Q8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

61622:EMP3
gene id: 61622:EMP3
uniprot id: A0A2K6QTS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

61622:CDK9
gene id: 61622:CDK9
uniprot id: A0A2K6R0R0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MPL
gene id: 61622:MPL
uniprot id: A0A2K6RPT5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.

61622:LEPR
gene id: 61622:LEPR
uniprot id: A0A2K6PUA7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61622:CAPN9
gene id: 61622:CAPN9
uniprot id: A0A2K6R008
uniprot id: A0A2K6R018
uniprot id: A0A2K6R039
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:STRN
gene id: 61622:STRN
uniprot id: A0A2K6QZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

61622:PPP3CC
gene id: 61622:PPP3CC
uniprot id: A0A2K6QD63
uniprot id: A0A2K6QD80
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

61622:LRP12
gene id: 61622:LRP12
uniprot id: A0A2K6NP38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CD5L
gene id: 61622:CD5L
uniprot id: A0A2K6QC66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ZRANB2
gene id: 61622:ZRANB2
uniprot id: A0A2K6NQW0
uniprot id: A0A2K6NQW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

61622:GANC
gene id: 61622:GANC
uniprot id: A0A2K6QWV9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

61622:CHST1
gene id: 61622:CHST1
uniprot id: A0A2K6NCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61622:PSME4
gene id: 61622:PSME4
uniprot id: A0A2K6RH18
names: Similarity
messages: Belongs to the BLM10 family.

61622:LHCGR
gene id: 61622:LHCGR
uniprot id: A0A2K6Q8W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

61622:NES
gene id: 61622:NES
uniprot id: A0A2K6PS34
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TMEM147
gene id: 61622:TMEM147
uniprot id: A0A2K6PCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

61622:PIM2
gene id: 61622:PIM2
uniprot id: A0A2K6Q2U4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

61622:DIABLO
gene id: 61622:DIABLO
uniprot id: A0A2K6PIP0
uniprot id: A0A2K6PIP8
names: Subcellular Location Annotation
messages: Mitochondrion

61622:SGK2
gene id: 61622:SGK2
uniprot id: A0A2K6PAB0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:VHL
gene id: 61622:VHL
uniprot id: A0A2K6N8R3
names: Similarity
messages: Belongs to the VHL family.

61622:LOC104661014
gene id: 61622:LOC104661014
uniprot id: A0A2K6NCK6
uniprot id: A0A2K6NCK8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:ART4
gene id: 61622:ART4
uniprot id: A0A2K6QV98
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

61622:DMRTA2
gene id: 61622:DMRTA2
uniprot id: A0A2K6NGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:AQR
gene id: 61622:AQR
uniprot id: A0A2K6RM35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

61622:MED20
gene id: 61622:MED20
uniprot id: A0A2K6RRF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:LOC104667781
gene id: 61622:LOC104667781
uniprot id: A0A2K6P4M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:LEP
gene id: 61622:LEP
uniprot id: F1AWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

61622:SBK3
gene id: 61622:SBK3
uniprot id: A0A2K6Q3L0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SKIL
gene id: 61622:SKIL
uniprot id: A0A2K6RP06
names: Similarity
messages: Belongs to the SKI family.

61622:INSL3
gene id: 61622:INSL3
uniprot id: A0A2K6R366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

61622:ING4
gene id: 61622:ING4
uniprot id: A0A2K6QW58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:TSPAN17
gene id: 61622:TSPAN17
uniprot id: A0A2K6QRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:COQ6
gene id: 61622:COQ6
uniprot id: A0A2K6RX83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

61622:CFHR2
gene id: 61622:CFHR2
uniprot id: A0A2K6RJE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TASOR
gene id: 61622:TASOR
uniprot id: A0A2K6NCM2
names: Similarity
messages: Belongs to the TASOR family.

61622:SLC41A2
gene id: 61622:SLC41A2
uniprot id: A0A2K6NDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

61622:IMPAD1
gene id: 61622:IMPAD1
uniprot id: A0A2K6NVK8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:GPRC5C
gene id: 61622:GPRC5C
uniprot id: A0A2K6PVF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TBPL2
gene id: 61622:TBPL2
uniprot id: A0A2K6QUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

61622:SSU72
gene id: 61622:SSU72
uniprot id: A0A2K6NAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

61622:TARS2
gene id: 61622:TARS2
uniprot id: A0A2K6PAC4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:PTGS2
gene id: 61622:PTGS2
uniprot id: A0A2K6QXQ8
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NOXA1
gene id: 61622:NOXA1
uniprot id: A0A2K6PU13
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

61622:BCAP31
gene id: 61622:BCAP31
uniprot id: A0A2K6RXF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

61622:LOC104657698
gene id: 61622:LOC104657698
uniprot id: A0A2K6QEL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

61622:SARS1
gene id: 61622:SARS1
uniprot id: A0A2K6QHG3
uniprot id: A0A2K6QHG4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

61622:CYGB
gene id: 61622:CYGB
uniprot id: A0A2K6QLH2
names: Similarity
messages: Belongs to the globin family.

61622:ACSL4
gene id: 61622:ACSL4
uniprot id: A0A2K6Q974
uniprot id: A0A2K6Q993
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:PSMG1
gene id: 61622:PSMG1
uniprot id: A0A2K6QG56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

61622:INPP5K
gene id: 61622:INPP5K
uniprot id: A0A2K6RH91
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

61622:SNW1
gene id: 61622:SNW1
uniprot id: A0A2K6PU52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

61622:ABCD3
gene id: 61622:ABCD3
uniprot id: A0A2K6QZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

61622:KEG34 p02
gene id: 61622:KEG34_p02
uniprot id: Q15GN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:CPO
gene id: 61622:CPO
uniprot id: A0A2K6NNH6
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:ZC3H12D
gene id: 61622:ZC3H12D
uniprot id: A0A2K6QIF6
names: Similarity
messages: Belongs to the ZC3H12 family.

61622:CALR3
gene id: 61622:CALR3
uniprot id: A0A2K6RS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

61622:HESX1
gene id: 61622:HESX1
uniprot id: A0A2K6PIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

61622:LOC104672407
gene id: 61622:LOC104672407
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:EIF1AD
gene id: 61622:EIF1AD
uniprot id: A0A2K6RTE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

61622:KHDC4
gene id: 61622:KHDC4
uniprot id: A0A2K6P6S2
names: Similarity
messages: Belongs to the KHDC4 family.

61622:GAST
gene id: 61622:GAST
uniprot id: A0A2K6RGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

61622:FAM124B
gene id: 61622:FAM124B
uniprot id: A0A2K6PM62
names: Similarity
messages: Belongs to the FAM124 family.

61622:RNF167
gene id: 61622:RNF167
uniprot id: A0A2K6RB08
names: Subcellular Location Annotation
messages: Membrane

61622:LAMB2
gene id: 61622:LAMB2
uniprot id: A0A2K6QAI5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61622:ACER1
gene id: 61622:ACER1
uniprot id: A0A2K6NMG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

61622:IFNAR1
gene id: 61622:IFNAR1
uniprot id: A0A2K6PT61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

61622:GPR65
gene id: 61622:GPR65
uniprot id: A0A2K6NFK1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:ARF3
gene id: 61622:ARF3
uniprot id: A0A2K6R8G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61622:GLS
gene id: 61622:GLS
uniprot id: A0A2K6R820
uniprot id: A0A2K6R830
names: Similarity
messages: Belongs to the glutaminase family.

61622:GRM5
gene id: 61622:GRM5
uniprot id: A0A2K6R3P5
uniprot id: A0A2K6R3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61622:TTC9
gene id: 61622:TTC9
uniprot id: A0A2K6N7U2
names: Similarity
messages: Belongs to the TTC9 family.

61622:AHSA1
gene id: 61622:AHSA1
uniprot id: A0A2K6QV38
names: Similarity
messages: Belongs to the AHA1 family.

61622:SEC61G
gene id: 61622:SEC61G
uniprot id: A0A2K6N728
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:FUZ
gene id: 61622:FUZ
uniprot id: A0A2K6QGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

61622:FAM120C
gene id: 61622:FAM120C
uniprot id: A0A2K6NM07
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

61622:FAN1
gene id: 61622:FAN1
uniprot id: A0A2K6PUC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

61622:SLC7A14
gene id: 61622:SLC7A14
uniprot id: A0A2K6Q6P1
names: Subcellular Location Annotation
messages: Membrane

61622:MFNG
gene id: 61622:MFNG
uniprot id: A0A2K6QTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:PROK1
gene id: 61622:PROK1
uniprot id: A0A2K6PWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

61622:FGR
gene id: 61622:FGR
uniprot id: A0A2K6QWA4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:MAT2B
gene id: 61622:MAT2B
uniprot id: A0A2K6NAP0
uniprot id: A0A2K6NAR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

61622:TMEM43
gene id: 61622:TMEM43
uniprot id: A0A2K6NTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

61622:ANKH
gene id: 61622:ANKH
uniprot id: A0A2K6QXA0
uniprot id: A0A2K6QXF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

61622:DPCD
gene id: 61622:DPCD
uniprot id: A0A2K6RMH4
names: Similarity
messages: Belongs to the DPCD family.

61622:LOC104654854
gene id: 61622:LOC104654854
uniprot id: A0A2K6R8K7
names: Subcellular Location Annotation
messages: Membrane

61622:SFXN4
gene id: 61622:SFXN4
uniprot id: A0A2K6NGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

61622:MTR
gene id: 61622:MTR
uniprot id: A0A2K6NMY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

61622:ADHFE1
gene id: 61622:ADHFE1
uniprot id: A0A2K6R4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

61622:MYO1C
gene id: 61622:MYO1C
uniprot id: A0A2K6PVN0
uniprot id: A0A2K6PVP1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:SLC26A1
gene id: 61622:SLC26A1
uniprot id: A0A2K6P5J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

61622:LOC104658178
gene id: 61622:LOC104658178
uniprot id: A0A2K6QBJ9
names: Similarity
messages: Belongs to the SPAN-X family.

61622:IFT57
gene id: 61622:IFT57
uniprot id: A0A2K6QL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

61622:RNF121
gene id: 61622:RNF121
uniprot id: A0A2K6N8R2
names: Subcellular Location Annotation
messages: Membrane

61622:NASP
gene id: 61622:NASP
uniprot id: A0A2K6NRJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

61622:DNASE1L1
gene id: 61622:DNASE1L1
uniprot id: A0A2K6QFD6
names: Similarity
messages: Belongs to the DNase I family.

61622:CPT1A
gene id: 61622:CPT1A
uniprot id: A0A2K6RAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:UROC1
gene id: 61622:UROC1
uniprot id: A0A2K6RX00
uniprot id: A0A2K6RX06
names: Similarity
messages: Belongs to the urocanase family.

61622:MOSPD1
gene id: 61622:MOSPD1
uniprot id: A0A2K6NGX7
names: Subcellular Location Annotation
messages: Membrane

61622:ESD
gene id: 61622:ESD
uniprot id: A0A2K6Q977
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

61622:CTSW
gene id: 61622:CTSW
uniprot id: A0A2K6PJK7
names: Similarity
messages: Belongs to the peptidase C1 family.

61622:LOC104657843
gene id: 61622:LOC104657843
uniprot id: A0A2K6NAB6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:CCNC
gene id: 61622:CCNC
uniprot id: A0A2K6PMF3
names: Similarity
messages: Belongs to the cyclin family.

61622:SLC30A4
gene id: 61622:SLC30A4
uniprot id: A0A2K6Q1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:PEX7
gene id: 61622:PEX7
uniprot id: A0A2K6QBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

61622:XCR1
gene id: 61622:XCR1
uniprot id: A0A2K6NAK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:FGF21
gene id: 61622:FGF21
uniprot id: A0A2K6QPG0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:NTSR1
gene id: 61622:NTSR1
uniprot id: A0A2K6P0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:TMEM170B
gene id: 61622:TMEM170B
uniprot id: A0A2K6NHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

61622:APOA1
gene id: 61622:APOA1
uniprot id: A0A2K6RLB7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

61622:FURIN
gene id: 61622:FURIN
uniprot id: A0A2K6Q7Q7
names: Similarity
messages: Belongs to the peptidase S8 family.

61622:PSMC4
gene id: 61622:PSMC4
uniprot id: A0A2K6QD83
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:RAD50
gene id: 61622:RAD50
uniprot id: A0A2K6QKN3
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

61622:ANKS1A
gene id: 61622:ANKS1A
uniprot id: A0A2K6PS79
names: Subcellular Location Annotation
messages: Cytoplasm

61622:KCNK4
gene id: 61622:KCNK4
uniprot id: A0A2K6P2K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:PCNA
gene id: 61622:PCNA
uniprot id: A0A2K6P1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

61622:FAT2
gene id: 61622:FAT2
uniprot id: A0A2K6QA51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ZNF277
gene id: 61622:ZNF277
uniprot id: A0A2K6R9K3
names: Similarity
messages: Belongs to the ZNF277 family.

61622:MYH10
gene id: 61622:MYH10
uniprot id: A0A2K6NJ14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:ANAPC13
gene id: 61622:ANAPC13
uniprot id: A0A2K6Q418
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

61622:SGCA
gene id: 61622:SGCA
uniprot id: A0A2K6QDU0
uniprot id: A0A2K6QDU2
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

61622:LAD1
gene id: 61622:LAD1
uniprot id: A0A2K6NS34
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

61622:FAM3A
gene id: 61622:FAM3A
uniprot id: A0A2K6RGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61622:SMDT1
gene id: 61622:SMDT1
uniprot id: A0A2K6QAU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61622:P4HA1
gene id: 61622:P4HA1
uniprot id: A0A2K6RLV4
uniprot id: A0A2K6RLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:NAV2
gene id: 61622:NAV2
uniprot id: A0A2K6Q510
names: Similarity
messages: Belongs to the Nav/unc-53 family.

61622:ZNF24
gene id: 61622:ZNF24
uniprot id: A0A2K6PR97
names: Subcellular Location Annotation
messages: Nucleus

61622:SLF2
gene id: 61622:SLF2
uniprot id: A0A2K6PIW9
names: Similarity
messages: Belongs to the FAM178 family.

61622:SLC26A4
gene id: 61622:SLC26A4
uniprot id: A0A2K6RM77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

61622:TAF6L
gene id: 61622:TAF6L
uniprot id: A0A2K6N7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

61622:LOC104661614
gene id: 61622:LOC104661614
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:CRABP1
gene id: 61622:CRABP1
uniprot id: A0A2K6QNW0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:LOC104653731
gene id: 61622:LOC104653731
uniprot id: A0A2K6QC75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:LOC104681253
gene id: 61622:LOC104681253
uniprot id: A0A2K6NC87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

61622:P4HB
gene id: 61622:P4HB
uniprot id: A0A2K6NTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

61622:ZNF449
gene id: 61622:ZNF449
uniprot id: A0A2K6P5N0
names: Subcellular Location Annotation
messages: Nucleus

61622:KLHL3
gene id: 61622:KLHL3
uniprot id: A0A2K6N881
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

61622:GCNT3
gene id: 61622:GCNT3
uniprot id: A0A2K6NE50
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61622:PTP4A2
gene id: 61622:PTP4A2
uniprot id: A0A2K6P7K9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61622:PSMB3
gene id: 61622:PSMB3
uniprot id: A0A2K6QZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:MEF2D
gene id: 61622:MEF2D
uniprot id: A0A2K6NBD7
uniprot id: A0A2K6NBE8
uniprot id: A0A2K6NBI9
names: Subcellular Location Annotation
messages: Nucleus

61622:DENND5A
gene id: 61622:DENND5A
uniprot id: A0A2K6QZ23
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TAS2R5
gene id: 61622:TAS2R5
uniprot id: A0A2K6NKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:GLO1
gene id: 61622:GLO1
uniprot id: A0A2K6QB47
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

61622:KIF14
gene id: 61622:KIF14
uniprot id: A0A2K6QVH7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:ERCC4
gene id: 61622:ERCC4
uniprot id: A0A2K6NLQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

61622:AK2
gene id: 61622:AK2
uniprot id: A0A2K6NBW2
uniprot id: A0A2K6NBX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

61622:PMM2
gene id: 61622:PMM2
uniprot id: A0A2K6R3E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61622:EVX1
gene id: 61622:EVX1
uniprot id: A0A2K6RQ49
names: Subcellular Location Annotation
messages: Nucleus

61622:SULT2A1
gene id: 61622:SULT2A1
uniprot id: A0A2K6PVG7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:TMOD4
gene id: 61622:TMOD4
uniprot id: A0A2K6QWA7
names: Subcellular Location Annotation
messages: cytoskeleton

61622:DCLK1
gene id: 61622:DCLK1
uniprot id: A0A2K6NKI4
uniprot id: A0A2K6NKJ9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

61622:ZDHHC17
gene id: 61622:ZDHHC17
uniprot id: A0A2K6QUN5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:SLC17A1
gene id: 61622:SLC17A1
uniprot id: A0A2K6RBR9
uniprot id: A0A2K6RBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

61622:FBLN5
gene id: 61622:FBLN5
uniprot id: A0A2K6P9B9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:EGFR
gene id: 61622:EGFR
uniprot id: A0A2K6R6K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

61622:BMT2
gene id: 61622:BMT2
uniprot id: A0A2K6PDW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

61622:LOC104670357
gene id: 61622:LOC104670357
uniprot id: A0A2K6RFN7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

61622:PPBP
gene id: 61622:PPBP
uniprot id: A0A2K6QGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:ADCK1
gene id: 61622:ADCK1
uniprot id: A0A2K6PC84
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61622:LOC104673816
gene id: 61622:LOC104673816
uniprot id: A0A2K6R6G2
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:ATP6AP2
gene id: 61622:ATP6AP2
uniprot id: A0A2K6PPE0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

61622:SH3YL1
gene id: 61622:SH3YL1
uniprot id: A0A2K6R017
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

61622:F8
gene id: 61622:F8
uniprot id: A0A2K6PW87
uniprot id: A0A2K6PW91
uniprot id: A0A2K6PWA1
names: Similarity
messages: Belongs to the multicopper oxidase family.

61622:LOC104670622
gene id: 61622:LOC104670622
uniprot id: A0A2K6Q2D4
names: Similarity
messages: Belongs to the intermediate filament family.

61622:LOC104659507
gene id: 61622:LOC104659507
uniprot id: A0A2K6Q8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:CMC2
gene id: 61622:CMC2
uniprot id: A0A2K6PV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

61622:PLSCR4
gene id: 61622:PLSCR4
uniprot id: A0A2K6QZ91
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:SLC45A1
gene id: 61622:SLC45A1
uniprot id: A0A2K6QGZ0
names: Subcellular Location Annotation
messages: Membrane

61622:POLR3A
gene id: 61622:POLR3A
uniprot id: A0A2K6NQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

61622:MYO1B
gene id: 61622:MYO1B
uniprot id: A0A2K6PH97
uniprot id: A0A2K6PHB8
uniprot id: A0A2K6PHI4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:MAP2K3
gene id: 61622:MAP2K3
uniprot id: A0A2K6Q8E2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SPTY2D1
gene id: 61622:SPTY2D1
uniprot id: A0A2K6QNQ4
names: Similarity
messages: Belongs to the SPT2 family.

61622:CPA6
gene id: 61622:CPA6
uniprot id: A0A2K6NIV0
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:TBCA
gene id: 61622:TBCA
uniprot id: A0A2K6QY21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

61622:COQ10B
gene id: 61622:COQ10B
uniprot id: A0A2K6R1U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

61622:KCNA7
gene id: 61622:KCNA7
uniprot id: A0A2K6RVR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SLC25A33
gene id: 61622:SLC25A33
uniprot id: A0A2K6RAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:LOC104660028
gene id: 61622:LOC104660028
uniprot id: A0A2K6RE05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

61622:HPSE
gene id: 61622:HPSE
uniprot id: A0A2K6PZU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61622:LOC104657997
gene id: 61622:LOC104657997
uniprot id: A0A2K6RES3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61622:GATA1
gene id: 61622:GATA1
uniprot id: A0A2K6Q0U2
names: Subcellular Location Annotation
messages: Nucleus

61622:HNF4A
gene id: 61622:HNF4A
uniprot id: A0A2K6P6E4
uniprot id: A0A2K6P6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:DYNLL2
gene id: 61622:DYNLL2
uniprot id: A0A2K6RL07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

61622:TM2D1
gene id: 61622:TM2D1
uniprot id: A0A2K6Q3T7
names: Subcellular Location Annotation
messages: Membrane

61622:WNT5B
gene id: 61622:WNT5B
uniprot id: A0A2K6RWI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:SLC28A2
gene id: 61622:SLC28A2
uniprot id: A0A2K6QRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

61622:SLC6A17
gene id: 61622:SLC6A17
uniprot id: A0A2K6QPF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:EMP1
gene id: 61622:EMP1
uniprot id: A0A2K6NEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61622:NCBP3
gene id: 61622:NCBP3
uniprot id: A0A2K6RJP2
uniprot id: A0A2K6RJR9
names: Similarity
messages: Belongs to the NCBP3 family.

61622:CALR
gene id: 61622:CALR
uniprot id: A0A2K6RPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

61622:DNA2
gene id: 61622:DNA2
uniprot id: A0A2K6PLJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

61622:SYNGR3
gene id: 61622:SYNGR3
uniprot id: A0A2K6NGX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

61622:LOC104676747
gene id: 61622:LOC104676747
uniprot id: A0A2K6RET2
uniprot id: A0A2K6RTM6
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

61622:NUDCD1
gene id: 61622:NUDCD1
uniprot id: A0A2K6Q341
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CDR2
gene id: 61622:CDR2
uniprot id: A0A2K6RQB9
names: Similarity
messages: Belongs to the CDR2 family.

61622:C8A
gene id: 61622:C8A
uniprot id: A0A2K6P7P3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:MAK16
gene id: 61622:MAK16
uniprot id: A0A2K6PHR4
names: Similarity
messages: Belongs to the MAK16 family.

61622:FRAT2
gene id: 61622:FRAT2
uniprot id: A0A2K6NA44
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

61622:MED17
gene id: 61622:MED17
uniprot id: A0A2K6PT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:CTSA
gene id: 61622:CTSA
uniprot id: A0A2K6Q8H0
names: Similarity
messages: Belongs to the peptidase S10 family.

61622:KCNJ8
gene id: 61622:KCNJ8
uniprot id: A0A2K6QA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:MRGPRF
gene id: 61622:MRGPRF
uniprot id: A0A2K6QBP8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SMIM14
gene id: 61622:SMIM14
uniprot id: A0A2K6QBD5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61622:LOC104676969
gene id: 61622:LOC104676969
uniprot id: A0A2K6Q4K7
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

61622:FYTTD1
gene id: 61622:FYTTD1
uniprot id: A0A2K6NH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

61622:TMEM45B
gene id: 61622:TMEM45B
uniprot id: A0A2K6RFG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

61622:USP27X
gene id: 61622:USP27X
uniprot id: A0A2K6QE20
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:PSMD1
gene id: 61622:PSMD1
uniprot id: A0A2K6RSX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

61622:CDKAL1
gene id: 61622:CDKAL1
uniprot id: A0A2K6RBS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

61622:PIGZ
gene id: 61622:PIGZ
uniprot id: A0A2K6P0Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ST8SIA5
gene id: 61622:ST8SIA5
uniprot id: A0A2K6PBH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:GSTK1
gene id: 61622:GSTK1
uniprot id: A0A2K6R5S8
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

61622:SAG
gene id: 61622:SAG
uniprot id: A0A2K6NDH8
names: Similarity
messages: Belongs to the arrestin family.

61622:CASC3
gene id: 61622:CASC3
uniprot id: A0A2K6NMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

61622:DBT
gene id: 61622:DBT
uniprot id: A0A2K6QHE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61622:LOC104670922
gene id: 61622:LOC104670922
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104667643
gene id: 61622:LOC104667643
uniprot id: A0A2K6RAV0
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61622:PUSL1
gene id: 61622:PUSL1
uniprot id: A0A2K6P8F4
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

61622:SCNN1B
gene id: 61622:SCNN1B
uniprot id: A0A2K6N8C0
names: Subcellular Location Annotation
messages: Membrane

61622:CASP3
gene id: 61622:CASP3
uniprot id: A0A2K6PL28
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:SETD2
gene id: 61622:SETD2
uniprot id: A0A2K6P108
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:BCAT1
gene id: 61622:BCAT1
uniprot id: A0A2K6R8Q7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

61622:SLC26A5
gene id: 61622:SLC26A5
uniprot id: A0A2K6PC41
uniprot id: A0A2K6PC93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ. Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane. The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC. The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization. The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding. Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and…

61622:ARAP2
gene id: 61622:ARAP2
uniprot id: A0A2K6R9P5
names: Subcellular Location Annotation
messages: Cytoplasm

61622:SLC6A13
gene id: 61622:SLC6A13
uniprot id: A0A2K6NCP6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61622:TSFM
gene id: 61622:TSFM
uniprot id: A0A2K6PF73
uniprot id: A0A2K6PF87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

61622:LOC104664917
gene id: 61622:LOC104664917
uniprot id: A0A2K6QIM4
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

61622:FXN
gene id: 61622:FXN
uniprot id: A0A2K6NML7
names: Similarity
messages: Belongs to the frataxin family.

61622:MKS1
gene id: 61622:MKS1
uniprot id: A0A2K6RAJ4
names: Subcellular Location Annotation
messages: cilium basal body

61622:AP3B1
gene id: 61622:AP3B1
uniprot id: A0A2K6PRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

61622:POLR3B
gene id: 61622:POLR3B
uniprot id: A0A2K6QZS6
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:ADGRF4
gene id: 61622:ADGRF4
uniprot id: A0A2K6Q656
names: Subcellular Location Annotation
messages: Membrane

61622:MB
gene id: 61622:MB
uniprot id: A0A2K6NL17
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

61622:ADH4
gene id: 61622:ADH4
uniprot id: A0A2K6P0S6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61622:NELFE
gene id: 61622:NELFE
uniprot id: A0A2K6R7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

61622:ACTN3
gene id: 61622:ACTN3
uniprot id: A0A2K6RJH4
names: Similarity
messages: Belongs to the alpha-actinin family.

61622:KCTD17
gene id: 61622:KCTD17
uniprot id: A0A2K6QXD6
uniprot id: A0A2K6QXJ3
names: Subcellular Location Annotation
messages: Cell membrane

61622:ITGB6
gene id: 61622:ITGB6
uniprot id: A0A2K6RPN7
uniprot id: A0A2K6RPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

61622:RAD17
gene id: 61622:RAD17
uniprot id: A0A2K6P5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

61622:LOC104675284
gene id: 61622:LOC104675284
uniprot id: A0A2K6NCR5
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

61622:PRCP
gene id: 61622:PRCP
uniprot id: A0A2K6R925
names: Similarity
messages: Belongs to the peptidase S28 family.

61622:ATXN7L3
gene id: 61622:ATXN7L3
uniprot id: A0A2K6QYE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

61622:CDADC1
gene id: 61622:CDADC1
uniprot id: A0A2K6PIV3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

61622:LAP3
gene id: 61622:LAP3
uniprot id: A0A2K6NPB6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

61622:TPM3
gene id: 61622:TPM3
uniprot id: A0A2K6P5Y2
uniprot id: A0A2K6P5Y7
uniprot id: A0A2K6P5Y9
uniprot id: A0A2K6P5Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:TELO2
gene id: 61622:TELO2
uniprot id: A0A2K6NVM0
names: Similarity
messages: Belongs to the TEL2 family.

61622:PATJ
gene id: 61622:PATJ
uniprot id: A0A2K6NF26
uniprot id: A0A2K6NF27
names: Subcellular Location Annotation
messages: tight junction

61622:TEK
gene id: 61622:TEK
uniprot id: A0A2K6P0H1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:OGG1
gene id: 61622:OGG1
uniprot id: A0A2K6QTI8
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

61622:FASLG
gene id: 61622:FASLG
uniprot id: A0A2K6R4V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

61622:BTN1A1
gene id: 61622:BTN1A1
uniprot id: A0A2K6PKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Cytoplasm
messages: Membrane

61622:GPR3
gene id: 61622:GPR3
uniprot id: A0A2K6NID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CCNB1
gene id: 61622:CCNB1
uniprot id: A0A2K6RQE6
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

61622:CD59
gene id: 61622:CD59
uniprot id: A0A2K6NNU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:IQCD
gene id: 61622:IQCD
uniprot id: A0A2K6NBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

61622:EIF4A1
gene id: 61622:EIF4A1
uniprot id: A0A2K6PHM2
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

61622:SLC35A5
gene id: 61622:SLC35A5
uniprot id: A0A2K6PDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:LIPF
gene id: 61622:LIPF
uniprot id: A0A2K6RV61
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:LOC104677995
gene id: 61622:LOC104677995
uniprot id: A0A2K6PKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

61622:SKP1
gene id: 61622:SKP1
uniprot id: A0A2K6RMZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

61622:MAT2A
gene id: 61622:MAT2A
uniprot id: A0A2K6QRB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

61622:TDRD9
gene id: 61622:TDRD9
uniprot id: A0A2K6QDT6
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

61622:SNX14
gene id: 61622:SNX14
uniprot id: A0A2K6PLN3
uniprot id: A0A2K6PLP1
names: Similarity
messages: Belongs to the sorting nexin family.

61622:FGFR1OP2
gene id: 61622:FGFR1OP2
uniprot id: A0A2K6PEZ5
uniprot id: A0A2K6PF56
names: Similarity
messages: Belongs to the SIKE family.

61622:ST3GAL4
gene id: 61622:ST3GAL4
uniprot id: A0A2K6RVG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:IL15RA
gene id: 61622:IL15RA
uniprot id: A0A2K6P311
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MARCO
gene id: 61622:MARCO
uniprot id: A0A2K6PFW7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ST6GALNAC5
gene id: 61622:ST6GALNAC5
uniprot id: A0A2K6RU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:WASHC1
gene id: 61622:WASHC1
uniprot id: A0A2K6P244
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

61622:DERL2
gene id: 61622:DERL2
uniprot id: A0A2K6R716
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ATP2B2
gene id: 61622:ATP2B2
uniprot id: A0A2K6PRX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SLC4A8
gene id: 61622:SLC4A8
uniprot id: A0A2K6RH75
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61622:MRPL16
gene id: 61622:MRPL16
uniprot id: A0A2K6QX42
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

61622:HEXA
gene id: 61622:HEXA
uniprot id: A0A2K6RNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

61622:TSC22D2
gene id: 61622:TSC22D2
uniprot id: A0A2K6PKC2
uniprot id: A0A2K6PKC4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61622:SHROOM3
gene id: 61622:SHROOM3
uniprot id: A0A2K6RPU3
uniprot id: A0A2K6RPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

61622:SLITRK4
gene id: 61622:SLITRK4
uniprot id: A0A2K6QB62
names: Similarity
messages: Belongs to the SLITRK family.

61622:TIGD4
gene id: 61622:TIGD4
uniprot id: A0A2K6NL06
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104679722
gene id: 61622:LOC104679722
uniprot id: A0A2K6REK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:VAPA
gene id: 61622:VAPA
uniprot id: A0A2K6P739
uniprot id: A0A2K6P756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PMM1
gene id: 61622:PMM1
uniprot id: A0A2K6NSU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61622:TADA1
gene id: 61622:TADA1
uniprot id: A0A2K6N9G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

61622:STK32A
gene id: 61622:STK32A
uniprot id: A0A2K6P4Z0
uniprot id: A0A2K6P4Z8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:REXO4
gene id: 61622:REXO4
uniprot id: A0A2K6NX40
names: Similarity
messages: Belongs to the REXO4 family.

61622:LOC104667064
gene id: 61622:LOC104667064
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:SLC26A7
gene id: 61622:SLC26A7
uniprot id: A0A2K6PBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

61622:ULK3
gene id: 61622:ULK3
uniprot id: A0A2K6RS63
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LITAF
gene id: 61622:LITAF
uniprot id: A0A2K6R383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

61622:AKR1E2
gene id: 61622:AKR1E2
uniprot id: A0A2K6QQA3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:KRT9
gene id: 61622:KRT9
uniprot id: A0A2K6R473
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SEPTIN5
gene id: 61622:SEPTIN5
uniprot id: A0A2K6R3G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:UCK1
gene id: 61622:UCK1
uniprot id: A0A2K6NME0
names: Similarity
messages: Belongs to the uridine kinase family.

61622:HOXD8
gene id: 61622:HOXD8
uniprot id: A0A2K6NPE3
names: Subcellular Location Annotation
messages: Nucleus

61622:DLX6
gene id: 61622:DLX6
uniprot id: A0A2K6PW56
names: Subcellular Location Annotation
messages: Nucleus

61622:CHGA
gene id: 61622:CHGA
uniprot id: A0A2K6QWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

61622:PLIN3
gene id: 61622:PLIN3
uniprot id: A0A2K6RKV8
names: Similarity
messages: Belongs to the perilipin family.

61622:MSH5
gene id: 61622:MSH5
uniprot id: A0A2K6PPS2
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

61622:GTF2B
gene id: 61622:GTF2B
uniprot id: A0A2K6NPI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

61622:CX3CL1
gene id: 61622:CX3CL1
uniprot id: A0A2K6R6T3
names: Subcellular Location Annotation
messages: Secreted

61622:TTC39B
gene id: 61622:TTC39B
uniprot id: A0A2K6QL12
names: Similarity
messages: Belongs to the TTC39 family.

61622:CD74
gene id: 61622:CD74
uniprot id: A0A2K6PVK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104674192
gene id: 61622:LOC104674192
uniprot id: A0A2K6NJG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:PPP1R1B
gene id: 61622:PPP1R1B
uniprot id: A0A2K6PCI1
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

61622:UGDH
gene id: 61622:UGDH
uniprot id: A0A2K6N858
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

61622:HMGCL
gene id: 61622:HMGCL
uniprot id: A0A2K6QWG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

61622:LOC104656901
gene id: 61622:LOC104656901
uniprot id: A0A2K6NTQ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:B4GALT4
gene id: 61622:B4GALT4
uniprot id: A0A2K6Q1J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:SYT17
gene id: 61622:SYT17
uniprot id: A0A2K6QG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

61622:TMEM184B
gene id: 61622:TMEM184B
uniprot id: A0A2K6QXV6
names: Subcellular Location Annotation
messages: Membrane

61622:NSMCE2
gene id: 61622:NSMCE2
uniprot id: A0A2K6QFC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

61622:KCTD20
gene id: 61622:KCTD20
uniprot id: A0A2K6RBN8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:AGXT2
gene id: 61622:AGXT2
uniprot id: A0A2K6Q4N6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61622:FNBP1L
gene id: 61622:FNBP1L
uniprot id: A0A2K6PW05
uniprot id: A0A2K6PW16
uniprot id: A0A2K6PW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

61622:FMO2
gene id: 61622:FMO2
uniprot id: A0A2K6R310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:EPAS1
gene id: 61622:EPAS1
uniprot id: A0A2K6R1G7
names: Subcellular Location Annotation
messages: Nucleus speckle

61622:TMED3
gene id: 61622:TMED3
uniprot id: A0A2K6P2L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61622:LOC104661474
gene id: 61622:LOC104661474
uniprot id: A0A2K6R1D7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

61622:KRT1
gene id: 61622:KRT1
uniprot id: A0A2K6RDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61622:LOC104673551
gene id: 61622:LOC104673551
uniprot id: A0A2K6P8B2
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

61622:OAZ1
gene id: 61622:OAZ1
uniprot id: A0A2K6QEV7
names: Similarity
messages: Belongs to the ODC antizyme family.

61622:PTGES3
gene id: 61622:PTGES3
uniprot id: A0A2K6PSW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

61622:PATZ1
gene id: 61622:PATZ1
uniprot id: A0A2K6QDE5
uniprot id: A0A2K6QDE6
uniprot id: A0A2K6QDH3
names: Subcellular Location Annotation
messages: Nucleus

61622:YBEY
gene id: 61622:YBEY
uniprot id: A0A2K6QSA3
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

61622:VPS28
gene id: 61622:VPS28
uniprot id: A0A2K6QG17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Membrane

61622:AGPAT3
gene id: 61622:AGPAT3
uniprot id: A0A2K6PAM5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

61622:SLC12A2
gene id: 61622:SLC12A2
uniprot id: A0A2K6PLM2
uniprot id: A0A2K6PLM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:PPIE
gene id: 61622:PPIE
uniprot id: A0A2K6RS34
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

61622:ZNF165
gene id: 61622:ZNF165
uniprot id: A0A2K6QBX8
names: Subcellular Location Annotation
messages: Nucleus

61622:WASF2
gene id: 61622:WASF2
uniprot id: A0A2K6NG28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

61622:SLC34A1
gene id: 61622:SLC34A1
uniprot id: A0A2K6P602
uniprot id: A0A2K6P609
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

61622:IRX1
gene id: 61622:IRX1
uniprot id: A0A2K6NSH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

61622:GNG3
gene id: 61622:GNG3
uniprot id: A0A2K6QDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61622:SUZ12
gene id: 61622:SUZ12
uniprot id: A0A2K6QD33
uniprot id: A0A2K6QD42
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

61622:LEPROT
gene id: 61622:LEPROT
uniprot id: A0A2K6RDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

61622:JPH3
gene id: 61622:JPH3
uniprot id: A0A2K6PS66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

61622:NRN1
gene id: 61622:NRN1
uniprot id: A0A2K6P1T2
names: Similarity
messages: Belongs to the neuritin family.

61622:PPM1B
gene id: 61622:PPM1B
uniprot id: A0A2K6RTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

61622:LBX2
gene id: 61622:LBX2
uniprot id: A0A2K6RCF9
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC43A3
gene id: 61622:SLC43A3
uniprot id: A0A2K6QL15
names: Subcellular Location Annotation
messages: Membrane

61622:NFKB2
gene id: 61622:NFKB2
uniprot id: A0A2K6PVE9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:MGST2
gene id: 61622:MGST2
uniprot id: A0A2K6NUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TRMT2B
gene id: 61622:TRMT2B
uniprot id: A0A2K6PCL3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DDC
gene id: 61622:DDC
uniprot id: A0A2K6QIQ8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61622:NFIC
gene id: 61622:NFIC
uniprot id: A0A2K6RQL1
uniprot id: A0A2K6RQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

61622:CHPT1
gene id: 61622:CHPT1
uniprot id: A0A2K6QQ76
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

61622:ITGA7
gene id: 61622:ITGA7
uniprot id: A0A2K6RKM6
uniprot id: A0A2K6RKN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GCHFR
gene id: 61622:GCHFR
uniprot id: A0A2K6QJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

61622:TMC8
gene id: 61622:TMC8
uniprot id: A0A2K6PS33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:CNKSR1
gene id: 61622:CNKSR1
uniprot id: A0A2K6P259
names: Similarity
messages: Belongs to the CNKSR family.

61622:SUSD4
gene id: 61622:SUSD4
uniprot id: A0A2K6PCU7
uniprot id: A0A2K6PCZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TRAPPC11
gene id: 61622:TRAPPC11
uniprot id: A0A2K6RUD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPPC11 family.
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

61622:IER5
gene id: 61622:IER5
uniprot id: A0A2K6N8T4
names: Similarity
messages: Belongs to the IER family.

61622:PGC
gene id: 61622:PGC
uniprot id: A0A2K6QZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

61622:RIPOR2
gene id: 61622:RIPOR2
uniprot id: A0A2K6QTT0
names: Similarity
messages: Belongs to the RIPOR family.

61622:FOXP1
gene id: 61622:FOXP1
uniprot id: A0A2K6RRI0
uniprot id: A0A2K6RRJ9
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC39A2
gene id: 61622:SLC39A2
uniprot id: A0A2K6PKE9
names: Subcellular Location Annotation
messages: Membrane

61622:PROP1
gene id: 61622:PROP1
uniprot id: A0A2K6QCQ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

61622:LETM1
gene id: 61622:LETM1
uniprot id: A0A2K6QN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:TADA3
gene id: 61622:TADA3
uniprot id: A0A2K6RS72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

61622:NAGLU
gene id: 61622:NAGLU
uniprot id: A0A2K6RPT0
names: Subcellular Location Annotation
messages: Lysosome

61622:MARK2
gene id: 61622:MARK2
uniprot id: A0A2K6P790
uniprot id: A0A2K6P7D5
uniprot id: A0A2K6P7E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61622:THRAP3
gene id: 61622:THRAP3
uniprot id: A0A2K6NVH4
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

61622:RPS4Y1
gene id: 61622:RPS4Y1
uniprot id: A0A2K6NS30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

61622:HOMER2
gene id: 61622:HOMER2
uniprot id: A0A2K6REU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

61622:SYNDIG1L
gene id: 61622:SYNDIG1L
uniprot id: A0A2K6R2G9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:DECR2
gene id: 61622:DECR2
uniprot id: A0A2K6Q3C5
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

61622:MASP2
gene id: 61622:MASP2
uniprot id: A0A2K6P3M1
uniprot id: A0A2K6P3P7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:KDM4C
gene id: 61622:KDM4C
uniprot id: A0A2K6RPA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

61622:CHURC1
gene id: 61622:CHURC1
uniprot id: A0A2K6QP38
names: Similarity
messages: Belongs to the Churchill family.

61622:TMEM18
gene id: 61622:TMEM18
uniprot id: A0A2K6NCQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

61622:NIBAN1
gene id: 61622:NIBAN1
uniprot id: A0A2K6PL74
names: Similarity
messages: Belongs to the Niban family.

61622:LOC104677083
gene id: 61622:LOC104677083
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:SBDS
gene id: 61622:SBDS
uniprot id: A0A2K6R0M0
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

61622:ZC3HC1
gene id: 61622:ZC3HC1
uniprot id: A0A2K6R719
names: Subcellular Location Annotation
messages: Nucleus

61622:CCDC86
gene id: 61622:CCDC86
uniprot id: A0A2K6RF38
names: Subcellular Location Annotation
messages: Nucleus

61622:ZNF274
gene id: 61622:ZNF274
uniprot id: A0A2K6RR07
names: Subcellular Location Annotation
messages: Nucleus

61622:BSPRY
gene id: 61622:BSPRY
uniprot id: A0A2K6NLE9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104675895
gene id: 61622:LOC104675895
uniprot id: A0A2K6N6W7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

61622:PRKCE
gene id: 61622:PRKCE
uniprot id: A0A2K6NZ12
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

61622:SOD1
gene id: 61622:SOD1
uniprot id: A0A2K6RMP3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

61622:FAM151A
gene id: 61622:FAM151A
uniprot id: A0A2K6P4Z4
names: Similarity
messages: Belongs to the FAM151 family.

61622:LOC104676875
gene id: 61622:LOC104676875
uniprot id: A0A2K6NM61
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

61622:NDUFB2
gene id: 61622:NDUFB2
uniprot id: A0A2K6P3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:TXNRD1
gene id: 61622:TXNRD1
uniprot id: A0A2K6PYF3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

61622:NEUROD4
gene id: 61622:NEUROD4
uniprot id: A0A2K6N9C6
names: Subcellular Location Annotation
messages: Nucleus

61622:HCFC2
gene id: 61622:HCFC2
uniprot id: A0A2K6QUU1
names: Subcellular Location Annotation
messages: Nucleus

61622:PKMYT1
gene id: 61622:PKMYT1
uniprot id: A0A2K6QNI6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LOC104682644
gene id: 61622:LOC104682644
uniprot id: A0A2K6NCY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ATP5F1D
gene id: 61622:ATP5F1D
uniprot id: A0A2K6RMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

61622:ACAA1
gene id: 61622:ACAA1
uniprot id: A0A2K6P348
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61622:ST8SIA6
gene id: 61622:ST8SIA6
uniprot id: A0A2K6RJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:POU2F2
gene id: 61622:POU2F2
uniprot id: A0A2K6QQI1
uniprot id: A0A2K6QQJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

61622:LOC104679976
gene id: 61622:LOC104679976
uniprot id: A0A2K6P786
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

61622:LOC104670641
gene id: 61622:LOC104670641
uniprot id: A0A2K6PEN7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:AJUBA
gene id: 61622:AJUBA
uniprot id: A0A2K6QW27
names: Similarity
messages: Belongs to the zyxin/ajuba family.

61622:AGTR2
gene id: 61622:AGTR2
uniprot id: A0A2K6NI00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

61622:PPP1R15A
gene id: 61622:PPP1R15A
uniprot id: A0A2K6RIN8
names: Similarity
messages: Belongs to the PPP1R15 family.

61622:PHOSPHO2
gene id: 61622:PHOSPHO2
uniprot id: A0A2K6N923
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

61622:MBD4
gene id: 61622:MBD4
uniprot id: A0A2K6NYN3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

61622:LOC104682234
gene id: 61622:LOC104682234
uniprot id: A0A2K6QHL3
names: Similarity
messages: Belongs to the serpin family.

61622:FAM162B
gene id: 61622:FAM162B
uniprot id: A0A2K6N8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

61622:MMP8
gene id: 61622:MMP8
uniprot id: A0A2K6QFW7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:MMP27
gene id: 61622:MMP27
uniprot id: A0A2K6NCW7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:LOC104665253
gene id: 61622:LOC104665253
uniprot id: A0A2K6NAW1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:TRIM34
gene id: 61622:TRIM34
uniprot id: A0A2K6QIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

61622:LOC104657390
gene id: 61622:LOC104657390
uniprot id: A0A2K6NGZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61622:P2RY1
gene id: 61622:P2RY1
uniprot id: A0A2K6QII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:RGS7BP
gene id: 61622:RGS7BP
uniprot id: A0A2K6NUN8
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

61622:PAX5
gene id: 61622:PAX5
uniprot id: A0A2K6REA3
names: Subcellular Location Annotation
messages: Nucleus

61622:RIMKLB
gene id: 61622:RIMKLB
uniprot id: A0A2K6PM56
names: Similarity
messages: Belongs to the RimK family.

61622:NAT10
gene id: 61622:NAT10
uniprot id: A0A2K6NF96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

61622:ARRB2
gene id: 61622:ARRB2
uniprot id: A0A2K6QR23
names: Similarity
messages: Belongs to the arrestin family.

61622:EIF2S2
gene id: 61622:EIF2S2
uniprot id: A0A2K6R3P7
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

61622:RPL6
gene id: 61622:RPL6
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:FAM219B
gene id: 61622:FAM219B
uniprot id: A0A2K6PBT5
names: Similarity
messages: Belongs to the FAM219 family.

61622:ADH5
gene id: 61622:ADH5
uniprot id: A0A2K6NCG6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

61622:MARCHF4
gene id: 61622:MARCHF4
uniprot id: A0A2K6R7H2
names: Subcellular Location Annotation
messages: Membrane

61622:DCST1
gene id: 61622:DCST1
uniprot id: A0A2K6RGF7
uniprot id: A0A2K6RGK7
names: Subcellular Location Annotation
messages: Membrane

61622:EIF3G
gene id: 61622:EIF3G
uniprot id: A0A2K6PP29
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

61622:MRPS9
gene id: 61622:MRPS9
uniprot id: A0A2K6RNJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

61622:ACKR2
gene id: 61622:ACKR2
uniprot id: A0A2K6NMH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

61622:GRB10
gene id: 61622:GRB10
uniprot id: A0A2K6QUF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

61622:SSRP1
gene id: 61622:SSRP1
uniprot id: A0A2K6PZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

61622:IL5RA
gene id: 61622:IL5RA
uniprot id: A0A2K6PU38
uniprot id: A0A2K6PU43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

61622:TM9SF4
gene id: 61622:TM9SF4
uniprot id: A0A2K6PB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61622:LOC104663594
gene id: 61622:LOC104663594
uniprot id: A0A2K6N764
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:KCTD14
gene id: 61622:KCTD14
uniprot id: A0A2K6P7R6
names: Subcellular Location Annotation
messages: Cell membrane

61622:FMNL2
gene id: 61622:FMNL2
uniprot id: A0A2K6NP40
names: Similarity
messages: Belongs to the formin homology family.

61622:GMFB
gene id: 61622:GMFB
uniprot id: A0A2K6P6R1
uniprot id: A0A2K6P6R6
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

61622:POU3F4
gene id: 61622:POU3F4
uniprot id: A0A2K6NLP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

61622:PLPP4
gene id: 61622:PLPP4
uniprot id: A0A2K6QGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:NCAPD3
gene id: 61622:NCAPD3
uniprot id: A0A2K6QU96
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

61622:AQP5
gene id: 61622:AQP5
uniprot id: A0A2K6PB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:TRPM3
gene id: 61622:TRPM3
uniprot id: A0A2K6NK24
uniprot id: A0A2K6NK45
uniprot id: A0A2K6NK46
uniprot id: A0A2K6NK47
uniprot id: A0A2K6NK68
names: Subcellular Location Annotation
messages: Membrane

61622:DAP3
gene id: 61622:DAP3
uniprot id: A0A2K6R3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

61622:KEAP1
gene id: 61622:KEAP1
uniprot id: A0A2K6R1R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

61622:TTYH3
gene id: 61622:TTYH3
uniprot id: A0A2K6RS96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

61622:MVB12B
gene id: 61622:MVB12B
uniprot id: A0A2K6NT26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:GPCPD1
gene id: 61622:GPCPD1
uniprot id: A0A2K6NXQ9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:SLC39A7
gene id: 61622:SLC39A7
uniprot id: A0A2K6PJA5
names: Subcellular Location Annotation
messages: Membrane

61622:OSM
gene id: 61622:OSM
uniprot id: A0A2K6QJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

61622:CMPK1
gene id: 61622:CMPK1
uniprot id: A0A2K6PGN7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

61622:GSK3A
gene id: 61622:GSK3A
uniprot id: A0A2K6NJW0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

61622:TOPAZ1
gene id: 61622:TOPAZ1
uniprot id: A0A2K6PG36
names: Function
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.

61622:SLC14A1
gene id: 61622:SLC14A1
uniprot id: A0A2K6PU07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

61622:SUCNR1
gene id: 61622:SUCNR1
uniprot id: A0A2K6PK50
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SLC37A2
gene id: 61622:SLC37A2
uniprot id: A0A2K6PAI5
uniprot id: A0A2K6PAQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

61622:LOC104667031
gene id: 61622:LOC104667031
uniprot id: A0A2K6QEQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:SYP
gene id: 61622:SYP
uniprot id: A0A2K6PV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61622:LOC104676509
gene id: 61622:LOC104676509
uniprot id: A0A2K6RA51
uniprot id: A0A2K6RA56
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:NAALAD2
gene id: 61622:NAALAD2
uniprot id: A0A2K6Q262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61622:CDKN2AIP
gene id: 61622:CDKN2AIP
uniprot id: A0A2K6P0E4
names: Similarity
messages: Belongs to the CARF family.

61622:RIOX1
gene id: 61622:RIOX1
uniprot id: A0A2K6NE12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

61622:AUP1
gene id: 61622:AUP1
uniprot id: A0A2K6PW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Membrane

61622:LOC104665503
gene id: 61622:LOC104665503
uniprot id: A0A2K6NNK3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:KRTCAP3
gene id: 61622:KRTCAP3
uniprot id: A0A2K6RC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

61622:ECHDC2
gene id: 61622:ECHDC2
uniprot id: A0A2K6R1H6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

61622:VASP
gene id: 61622:VASP
uniprot id: A0A2K6RPW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

61622:CDC26
gene id: 61622:CDC26
uniprot id: A0A2K6PNX1
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

61622:FLCN
gene id: 61622:FLCN
uniprot id: A0A2K6PQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

61622:IARS1
gene id: 61622:IARS1
uniprot id: A0A2K6NXR2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:RHAG
gene id: 61622:RHAG
uniprot id: A0A2K6R8H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

61622:LOC104677541
gene id: 61622:LOC104677541
uniprot id: A0A2K6P2T5
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

61622:LOC104675453
gene id: 61622:LOC104675453
uniprot id: A0A2K6PQ11
uniprot id: A0A2K6PQ36
uniprot id: Q4VUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

61622:PAIP2B
gene id: 61622:PAIP2B
uniprot id: A0A2K6P2L6
names: Similarity
messages: Belongs to the PAIP2 family.

61622:ZSCAN23
gene id: 61622:ZSCAN23
uniprot id: A0A2K6RRD1
names: Subcellular Location Annotation
messages: Nucleus

61622:TRDMT1
gene id: 61622:TRDMT1
uniprot id: A0A2K6QLL2
uniprot id: A0A2K6QLM0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

61622:KCNN4
gene id: 61622:KCNN4
uniprot id: A0A2K6PF20
names: Subcellular Location Annotation
messages: Membrane

61622:COQ9
gene id: 61622:COQ9
uniprot id: A0A2K6P556
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

61622:STAB2
gene id: 61622:STAB2
uniprot id: A0A2K6NLD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CDH18
gene id: 61622:CDH18
uniprot id: A0A2K6QFI0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:SUPT5H
gene id: 61622:SUPT5H
uniprot id: A0A2K6NKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

61622:DMRT2
gene id: 61622:DMRT2
uniprot id: A0A2K6NUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:CCT6B
gene id: 61622:CCT6B
uniprot id: A0A2K6PCL0
uniprot id: A0A2K6PCT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

61622:LOC104661036
gene id: 61622:LOC104661036
uniprot id: A0A2K6PCQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:STRADB
gene id: 61622:STRADB
uniprot id: A0A2K6Q070
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

61622:GHSR
gene id: 61622:GHSR
uniprot id: A0A2K6Q2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:NUTM2F
gene id: 61622:NUTM2F
uniprot id: A0A2K6PVP0
uniprot id: A0A2K6PVP9
names: Similarity
messages: Belongs to the NUT family.

61622:SMIM12
gene id: 61622:SMIM12
uniprot id: A0A2K6N8P8
names: Similarity
messages: Belongs to the SMIM12 family.

61622:PPTC7
gene id: 61622:PPTC7
uniprot id: A0A2K6QEN4
names: Similarity
messages: Belongs to the PP2C family.

61622:STK11
gene id: 61622:STK11
uniprot id: A0A2K6NMW4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

61622:CHCHD4
gene id: 61622:CHCHD4
uniprot id: A0A2K6PLV6
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

61622:SNU13
gene id: 61622:SNU13
uniprot id: A0A2K6RBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

61622:TFEC
gene id: 61622:TFEC
uniprot id: A0A2K6RDG9
uniprot id: A0A2K6RDH8
uniprot id: A0A2K6RDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61622:SH3BGRL2
gene id: 61622:SH3BGRL2
uniprot id: A0A2K6Q0W0
names: Similarity
messages: Belongs to the SH3BGR family.

61622:PIGS
gene id: 61622:PIGS
uniprot id: A0A2K6QJE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ZDHHC3
gene id: 61622:ZDHHC3
uniprot id: A0A2K6PJ17
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104675028
gene id: 61622:LOC104675028
uniprot id: A0A2K6QTU3
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:LOC104672160
gene id: 61622:LOC104672160
uniprot id: A0A2K6QYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

61622:LOC104672415
gene id: 61622:LOC104672415
uniprot id: A0A2K6NW60
names: Similarity
messages: Belongs to the CFAP36 family.

61622:KCTD19
gene id: 61622:KCTD19
uniprot id: A0A2K6PMV8
names: Subcellular Location Annotation
messages: Cell membrane

61622:PITHD1
gene id: 61622:PITHD1
uniprot id: A0A2K6QU74
names: Similarity
messages: Belongs to the PITHD1 family.

61622:MYOZ1
gene id: 61622:MYOZ1
uniprot id: A0A2K6QS64
names: Similarity
messages: Belongs to the myozenin family.

61622:HYAL3
gene id: 61622:HYAL3
uniprot id: A0A2K6PF24
uniprot id: A0A2K6PF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Membrane
messages: acrosome

61622:SF3A2
gene id: 61622:SF3A2
uniprot id: A0A2K6PWX6
names: Similarity
messages: Belongs to the SF3A2 family.

61622:GTF2A1L
gene id: 61622:GTF2A1L
uniprot id: A0A2K6QU86
uniprot id: A0A2K6QU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

61622:SFXN2
gene id: 61622:SFXN2
uniprot id: A0A2K6NVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

61622:ARRDC3
gene id: 61622:ARRDC3
uniprot id: A0A2K6NED3
names: Similarity
messages: Belongs to the arrestin family.

61622:SYCP2
gene id: 61622:SYCP2
uniprot id: A0A2K6Q6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

61622:IGFBP1
gene id: 61622:IGFBP1
uniprot id: A0A2K6R2R1
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:RAX2
gene id: 61622:RAX2
uniprot id: A0A2K6P2T0
names: Subcellular Location Annotation
messages: Nucleus

61622:ENTPD5
gene id: 61622:ENTPD5
uniprot id: A0A2K6R7E5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:TRIM21
gene id: 61622:TRIM21
uniprot id: A0A2K6Q408
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:ITIH2
gene id: 61622:ITIH2
uniprot id: A0A2K6Q168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:SLITRK6
gene id: 61622:SLITRK6
uniprot id: A0A2K6NIV7
names: Similarity
messages: Belongs to the SLITRK family.

61622:VIP
gene id: 61622:VIP
uniprot id: A0A2K6Q148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

61622:CTSS
gene id: 61622:CTSS
uniprot id: A0A2K6QTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:C21H18orf21
gene id: 61622:C21H18orf21
uniprot id: A0A2K6NSB9
names: Similarity
messages: Belongs to the UPF0711 family.

61622:PPM1A
gene id: 61622:PPM1A
uniprot id: A0A2K6RD30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

61622:NDUFS3
gene id: 61622:NDUFS3
uniprot id: A0A2K6PD09
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

61622:ACAD8
gene id: 61622:ACAD8
uniprot id: A0A2K6QEY2
uniprot id: A0A2K6QEZ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:PADI3
gene id: 61622:PADI3
uniprot id: A0A2K6RNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61622:DUT
gene id: 61622:DUT
uniprot id: A0A2K6R6V6
uniprot id: A0A2K6R6V8
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

61622:PDIA4
gene id: 61622:PDIA4
uniprot id: A0A2K6RLF4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

61622:TPP2
gene id: 61622:TPP2
uniprot id: A0A2K6R1N1
names: Similarity
messages: Belongs to the peptidase S8 family.

61622:PARP1
gene id: 61622:PARP1
uniprot id: A0A2K6NZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

61622:LTBP4
gene id: 61622:LTBP4
uniprot id: A0A2K6NZN9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:TMEM106B
gene id: 61622:TMEM106B
uniprot id: A0A2K6PBR1
names: Similarity
messages: Belongs to the TMEM106 family.

61622:HOXB1
gene id: 61622:HOXB1
uniprot id: A0A2K6RCN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

61622:KRT79
gene id: 61622:KRT79
uniprot id: A0A2K6QQH5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:BAMBI
gene id: 61622:BAMBI
uniprot id: A0A2K6RW07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

61622:TAX1BP3
gene id: 61622:TAX1BP3
uniprot id: A0A2K6R5C2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

61622:LARS2
gene id: 61622:LARS2
uniprot id: A0A2K6RI47
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:MRPL24
gene id: 61622:MRPL24
uniprot id: A0A2K6NJL4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:SATB2
gene id: 61622:SATB2
uniprot id: A0A2K6RQP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:KCNC2
gene id: 61622:KCNC2
uniprot id: A0A2K6NXB0
uniprot id: A0A2K6NXB7
uniprot id: A0A2K6NXB8
uniprot id: A0A2K6NXC1
uniprot id: A0A2K6NXC4
uniprot id: A0A2K6NXC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:B9D2
gene id: 61622:B9D2
uniprot id: A0A2K6RWP2
names: Subcellular Location Annotation
messages: cilium basal body

61622:ALX1
gene id: 61622:ALX1
uniprot id: A0A2K6NGZ1
names: Subcellular Location Annotation
messages: Nucleus

61622:LPAR1
gene id: 61622:LPAR1
uniprot id: A0A2K6PSN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

61622:SLC66A2
gene id: 61622:SLC66A2
uniprot id: A0A2K6PQB2
uniprot id: A0A2K6PQB8
uniprot id: A0A2K6PQC0
names: Subcellular Location Annotation
messages: Membrane

61622:ENO1
gene id: 61622:ENO1
uniprot id: A0A2K6QN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

61622:TMEM205
gene id: 61622:TMEM205
uniprot id: A0A2K6QAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

61622:LOC104666527
gene id: 61622:LOC104666527
uniprot id: A0A2K6P289
uniprot id: A0A2K6P2A0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:ICAM2
gene id: 61622:ICAM2
uniprot id: A0A2K6QHE8
uniprot id: A0A2K6QHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:STAT4
gene id: 61622:STAT4
uniprot id: A0A2K6RT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:ACOT8
gene id: 61622:ACOT8
uniprot id: A0A2K6NTN5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:SYNDIG1
gene id: 61622:SYNDIG1
uniprot id: A0A2K6PUY4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:RPA3
gene id: 61622:RPA3
uniprot id: A0A2K6QE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

61622:LOC104678904
gene id: 61622:LOC104678904
uniprot id: A0A2K6RX77
uniprot id: A0A2K6RX79
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CD46
gene id: 61622:CD46
uniprot id: A0A2K6RJJ8
uniprot id: A0A2K6RJK7
uniprot id: A0A2K6RJN7
uniprot id: A0A2K6RJP1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

61622:SLC46A2
gene id: 61622:SLC46A2
uniprot id: A0A2K6PFX0
uniprot id: A0A2K6PFX8
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104672151
gene id: 61622:LOC104672151
uniprot id: A0A2K6Q3U5
uniprot id: A0A2K6Q3V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:BAAT
gene id: 61622:BAAT
uniprot id: A0A2K6NJ13
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:RNF168
gene id: 61622:RNF168
uniprot id: A0A2K6RJU2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

61622:MRI1
gene id: 61622:MRI1
uniprot id: A0A2K6PBM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

61622:NLGN4X
gene id: 61622:NLGN4X
uniprot id: A0A2K6P1U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

61622:TWSG1
gene id: 61622:TWSG1
uniprot id: A0A2K6RWR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

61622:TSPAN11
gene id: 61622:TSPAN11
uniprot id: A0A2K6QPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:COMP
gene id: 61622:COMP
uniprot id: A0A2K6RK05
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PDK1
gene id: 61622:PDK1
uniprot id: A0A2K6RN94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:GINS4
gene id: 61622:GINS4
uniprot id: A0A2K6NR12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

61622:ISCA1
gene id: 61622:ISCA1
uniprot id: A0A2K6Q879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

61622:DDAH2
gene id: 61622:DDAH2
uniprot id: A0A2K6PQZ4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

61622:AQP7
gene id: 61622:AQP7
uniprot id: A0A2K6PQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:SLC50A1
gene id: 61622:SLC50A1
uniprot id: A0A2K6R2U7
uniprot id: A0A2K6R2W5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

61622:VEZT
gene id: 61622:VEZT
uniprot id: A0A2K6RHA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

61622:ACTRT3
gene id: 61622:ACTRT3
uniprot id: A0A2K6Q218
names: Similarity
messages: Belongs to the actin family.

61622:TMEM30B
gene id: 61622:TMEM30B
uniprot id: A0A2K6NLK5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

61622:YTHDC1
gene id: 61622:YTHDC1
uniprot id: A0A2K6Q0P7
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

61622:LOC104667089
gene id: 61622:LOC104667089
uniprot id: A0A2K6NNL8
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

61622:RAB38
gene id: 61622:RAB38
uniprot id: A0A2K6N7Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

61622:SCD
gene id: 61622:SCD
uniprot id: A0A2K6QV31
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

61622:LOC104663637
gene id: 61622:LOC104663637
uniprot id: A0A2K6NNH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

61622:LOC104658884
gene id: 61622:LOC104658884
uniprot id: A0A2K6RRT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:PPP1R11
gene id: 61622:PPP1R11
uniprot id: A0A2K6RHC2
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

61622:METAP1
gene id: 61622:METAP1
uniprot id: A0A2K6RA24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

61622:PPP4R3A
gene id: 61622:PPP4R3A
uniprot id: A0A2K6PEF6
names: Similarity
messages: Belongs to the SMEK family.

61622:CEBPE
gene id: 61622:CEBPE
uniprot id: A0A2K6QUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

61622:LOC104658501
gene id: 61622:LOC104658501
uniprot id: A0A2K6Q7H3
names: Similarity
messages: Belongs to the intermediate filament family.

61622:HAUS3
gene id: 61622:HAUS3
uniprot id: A0A2K6PQN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

61622:HTR7
gene id: 61622:HTR7
uniprot id: A0A2K6P5G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PCNX3
gene id: 61622:PCNX3
uniprot id: A0A2K6PDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

61622:CRYZ
gene id: 61622:CRYZ
uniprot id: A0A2K6N9E1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61622:C13H20orf27
gene id: 61622:C13H20orf27
uniprot id: A0A2K6R1L9
names: Similarity
messages: Belongs to the ADISSP family.

61622:ASF1B
gene id: 61622:ASF1B
uniprot id: A0A2K6PJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

61622:TAS2R14
gene id: 61622:TAS2R14
uniprot id: A0A2K6NQ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:GATM
gene id: 61622:GATM
uniprot id: A0A2K6PAN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

61622:BMPR1A
gene id: 61622:BMPR1A
uniprot id: A0A2K6Q600
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:DOLK
gene id: 61622:DOLK
uniprot id: A0A2K6NQA3
names: Similarity
messages: Belongs to the polyprenol kinase family.

61622:SUGP1
gene id: 61622:SUGP1
uniprot id: A0A2K6P4H9
names: Subcellular Location Annotation
messages: Nucleus

61622:ATP2C1
gene id: 61622:ATP2C1
uniprot id: A0A2K6NCL5
uniprot id: A0A2K6NCP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NLRP2
gene id: 61622:NLRP2
uniprot id: A0A2K6NJX4
names: Similarity
messages: Belongs to the NLRP family.

61622:MEIG1
gene id: 61622:MEIG1
uniprot id: A0A2K6QNN1
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

61622:KRR1
gene id: 61622:KRR1
uniprot id: A0A2K6P1U6
uniprot id: A0A2K6P1V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

61622:PSEN1
gene id: 61622:PSEN1
uniprot id: A0A2K6NMU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

61622:ST6GALNAC1
gene id: 61622:ST6GALNAC1
uniprot id: A0A2K6N9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:NPAS4
gene id: 61622:NPAS4
uniprot id: A0A2K6PF19
names: Subcellular Location Annotation
messages: Nucleus

61622:KCNK6
gene id: 61622:KCNK6
uniprot id: A0A2K6RBW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:GSC
gene id: 61622:GSC
uniprot id: A0A2K6QAH5
names: Subcellular Location Annotation
messages: Nucleus

61622:DIPK2B
gene id: 61622:DIPK2B
uniprot id: A0A2K6R515
uniprot id: A0A2K6R519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

61622:GCH1
gene id: 61622:GCH1
uniprot id: A0A2K6RPE5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

61622:B3GAT3
gene id: 61622:B3GAT3
uniprot id: A0A2K6P2K3
uniprot id: A0A2K6P2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:UBA2
gene id: 61622:UBA2
uniprot id: A0A2K6PGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

61622:TNFSF13
gene id: 61622:TNFSF13
uniprot id: A0A2K6REC9
uniprot id: A0A2K6RED3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:PANX1
gene id: 61622:PANX1
uniprot id: A0A2K6PJL4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61622:ANP32A
gene id: 61622:ANP32A
uniprot id: A0A2K6P0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

61622:NEUROD1
gene id: 61622:NEUROD1
uniprot id: A0A2K6ND93
names: Subcellular Location Annotation
messages: Nucleus

61622:JAG1
gene id: 61622:JAG1
uniprot id: A0A2K6PBB4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61622:ATG2A
gene id: 61622:ATG2A
uniprot id: A0A2K6NP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

61622:TCEANC2
gene id: 61622:TCEANC2
uniprot id: A0A2K6NF03
names: Subcellular Location Annotation
messages: Nucleus

61622:TYRP1
gene id: 61622:TYRP1
uniprot id: A0A2K6Q4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61622:TSN
gene id: 61622:TSN
uniprot id: A0A2K6P3U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

61622:SCN9A
gene id: 61622:SCN9A
uniprot id: A0A2K6Q6T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

61622:ARPC1A
gene id: 61622:ARPC1A
uniprot id: A0A2K6PWQ3
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

61622:EIF1B
gene id: 61622:EIF1B
uniprot id: A0A2K6QX21
names: Similarity
messages: Belongs to the SUI1 family.

61622:TMEM9
gene id: 61622:TMEM9
uniprot id: A0A2K6QEN9
names: Similarity
messages: Belongs to the TMEM9 family.

61622:TMEM106C
gene id: 61622:TMEM106C
uniprot id: A0A2K6NLS7
names: Similarity
messages: Belongs to the TMEM106 family.

61622:FBL
gene id: 61622:FBL
uniprot id: A0A2K6NFU3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

61622:NXT2
gene id: 61622:NXT2
uniprot id: A0A2K6Q7Z4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

61622:FIGN
gene id: 61622:FIGN
uniprot id: A0A2K6R1Y2
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:FBXO32
gene id: 61622:FBXO32
uniprot id: A0A2K6R033
names: Subcellular Location Annotation
messages: Nucleus

61622:SAMM50
gene id: 61622:SAMM50
uniprot id: A0A2K6R1J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

61622:ENPP2
gene id: 61622:ENPP2
uniprot id: A0A2K6NPY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

61622:LOC104674031
gene id: 61622:LOC104674031
uniprot id: A0A2K6NRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:HIF3A
gene id: 61622:HIF3A
uniprot id: A0A2K6PLE5
uniprot id: A0A2K6PLF3
uniprot id: A0A2K6PLL3
names: Subcellular Location Annotation
messages: Nucleus speckle

61622:CBX7
gene id: 61622:CBX7
uniprot id: A0A2K6PS30
names: Subcellular Location Annotation
messages: Nucleus

61622:CLDN9
gene id: 61622:CLDN9
uniprot id: A0A2K6NJ02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:PHYHIPL
gene id: 61622:PHYHIPL
uniprot id: A0A2K6R1F9
names: Similarity
messages: Belongs to the PHYHIP family.

61622:TFCP2L1
gene id: 61622:TFCP2L1
uniprot id: A0A2K6QVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:ELF2
gene id: 61622:ELF2
uniprot id: A0A2K6PC08
uniprot id: A0A2K6PC56
uniprot id: A0A2K6PC61
uniprot id: A0A2K6PCA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:VANGL1
gene id: 61622:VANGL1
uniprot id: A0A2K6RWG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

61622:BLMH
gene id: 61622:BLMH
uniprot id: A0A2K6PC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

61622:SPESP1
gene id: 61622:SPESP1
uniprot id: A0A2K6PDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.
messages: acrosome

61622:SCTR
gene id: 61622:SCTR
uniprot id: A0A2K6RF70
names: Subcellular Location Annotation
messages: Membrane

61622:ITGA5
gene id: 61622:ITGA5
uniprot id: A0A2K6RWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:PPP2R5E
gene id: 61622:PPP2R5E
uniprot id: A0A2K6NN28
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:ALDH3A1
gene id: 61622:ALDH3A1
uniprot id: A0A2K6NZ61
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:ALKBH2
gene id: 61622:ALKBH2
uniprot id: A0A2K6PVN6
names: Similarity
messages: Belongs to the alkB family.

61622:GPR183
gene id: 61622:GPR183
uniprot id: A0A2K6NDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:RDM1
gene id: 61622:RDM1
uniprot id: A0A2K6Q1Y1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

61622:NIPSNAP3A
gene id: 61622:NIPSNAP3A
uniprot id: A0A2K6PAB4
names: Similarity
messages: Belongs to the NipSnap family.

61622:RARRES2
gene id: 61622:RARRES2
uniprot id: A0A2K6NTI8
names: Subcellular Location Annotation
messages: Secreted

61622:LOC104666513
gene id: 61622:LOC104666513
uniprot id: A0A2K6RVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:TTC38
gene id: 61622:TTC38
uniprot id: A0A2K6NNZ6
names: Similarity
messages: Belongs to the TTC38 family.

61622:APOH
gene id: 61622:APOH
uniprot id: A0A2K6QY04
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:SPON2
gene id: 61622:SPON2
uniprot id: A0A2K6PZ73
names: Subcellular Location Annotation
messages: extracellular matrix

61622:PRKAR2B
gene id: 61622:PRKAR2B
uniprot id: A0A2K6R4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61622:TNFSF10
gene id: 61622:TNFSF10
uniprot id: A0A2K6NUD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

61622:PSPH
gene id: 61622:PSPH
uniprot id: A0A2K6Q4V0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

61622:AP1B1
gene id: 61622:AP1B1
uniprot id: A0A2K6P3Y6
uniprot id: A0A2K6P3Z1
uniprot id: A0A2K6P403
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:RPLP0
gene id: 61622:RPLP0
uniprot id: A0A2K6RBN1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

61622:MVP
gene id: 61622:MVP
uniprot id: A0A2K6PIA2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

61622:PWWP3B
gene id: 61622:PWWP3B
uniprot id: A0A2K6NUA0
names: Similarity
messages: Belongs to the PWWP3A family.

61622:NDST2
gene id: 61622:NDST2
uniprot id: A0A2K6R405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

61622:TM7SF2
gene id: 61622:TM7SF2
uniprot id: A0A2K6QL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

61622:PMP22
gene id: 61622:PMP22
uniprot id: A0A2K6QR24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

61622:GPR89A
gene id: 61622:GPR89A
uniprot id: A0A2K6PBR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

61622:LOC104670855
gene id: 61622:LOC104670855
uniprot id: A0A2K6NPK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:INTS13
gene id: 61622:INTS13
uniprot id: A0A2K6RGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

61622:SLC35A2
gene id: 61622:SLC35A2
uniprot id: A0A2K6QWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:EIF4E3
gene id: 61622:EIF4E3
uniprot id: A0A2K6NHF9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61622:ACAD9
gene id: 61622:ACAD9
uniprot id: A0A2K6QFM6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:CDH19
gene id: 61622:CDH19
uniprot id: A0A2K6RL41
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:ARMCX1
gene id: 61622:ARMCX1
uniprot id: A0A2K6NK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

61622:RPL35A
gene id: 61622:RPL35A
uniprot id: A0A2K6ND08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

61622:ADAMTS10
gene id: 61622:ADAMTS10
uniprot id: A0A2K6R7L7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:PDE1B
gene id: 61622:PDE1B
uniprot id: A0A2K6R2F5
uniprot id: A0A2K6R2I7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:SOHLH2
gene id: 61622:SOHLH2
uniprot id: A0A2K6QAP6
names: Subcellular Location Annotation
messages: Nucleus

61622:MFSD3
gene id: 61622:MFSD3
uniprot id: A0A2K6PXN6
names: Subcellular Location Annotation
messages: Membrane

61622:SLC29A1
gene id: 61622:SLC29A1
uniprot id: A0A2K6NXJ2
uniprot id: A0A2K6NXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

61622:UFM1
gene id: 61622:UFM1
uniprot id: A0A2K6P8G3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

61622:EXOSC5
gene id: 61622:EXOSC5
uniprot id: A0A2K6RKX0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:VPS16
gene id: 61622:VPS16
uniprot id: A0A2K6RA00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

61622:TMEM161A
gene id: 61622:TMEM161A
uniprot id: A0A2K6NPG7
uniprot id: A0A2K6NPH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

61622:SERINC5
gene id: 61622:SERINC5
uniprot id: A0A2K6QCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61622:BARHL2
gene id: 61622:BARHL2
uniprot id: A0A2K6RM96
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104666730
gene id: 61622:LOC104666730
uniprot id: A0A2K6NCK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104663549
gene id: 61622:LOC104663549
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:RGS4
gene id: 61622:RGS4
uniprot id: A0A2K6NP72
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

61622:LOC104664037
gene id: 61622:LOC104664037
uniprot id: A0A2K6QT05
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:FAM83F
gene id: 61622:FAM83F
uniprot id: A0A2K6PCA2
names: Similarity
messages: Belongs to the FAM83 family.

61622:TBX10
gene id: 61622:TBX10
uniprot id: A0A2K6QTG5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:PDE6D
gene id: 61622:PDE6D
uniprot id: A0A2K6NXT8
uniprot id: A0A2K6NXU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

61622:LOC104654088
gene id: 61622:LOC104654088
uniprot id: A0A2K6QRV3
names: Similarity
messages: Belongs to the CLCR family.

61622:CTSH
gene id: 61622:CTSH
uniprot id: A0A2K6NTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:TUBG2
gene id: 61622:TUBG2
uniprot id: A0A2K6PDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

61622:SLC39A4
gene id: 61622:SLC39A4
uniprot id: A0A2K6PGN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

61622:PROS1
gene id: 61622:PROS1
uniprot id: A0A2K6P871
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DUSP16
gene id: 61622:DUSP16
uniprot id: A0A2K6PKN1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61622:OSTC
gene id: 61622:OSTC
uniprot id: A0A2K6PD16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

61622:TBCE
gene id: 61622:TBCE
uniprot id: A0A2K6NEQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

61622:PEX12
gene id: 61622:PEX12
uniprot id: A0A2K6QZH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

61622:DNAJA2
gene id: 61622:DNAJA2
uniprot id: A0A2K6R3H1
names: Subcellular Location Annotation
messages: Membrane

61622:DTNA
gene id: 61622:DTNA
uniprot id: A0A2K6RHF0
uniprot id: A0A2K6RHG8
uniprot id: A0A2K6RHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

61622:TACR1
gene id: 61622:TACR1
uniprot id: A0A2K6NH56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

61622:FREM2
gene id: 61622:FREM2
uniprot id: A0A2K6QKK7
names: Similarity
messages: Belongs to the FRAS1 family.

61622:ASB18
gene id: 61622:ASB18
uniprot id: A0A2K6NEV5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:ZNF397
gene id: 61622:ZNF397
uniprot id: A0A2K6NU53
names: Subcellular Location Annotation
messages: Nucleus

61622:HTR1A
gene id: 61622:HTR1A
uniprot id: A0A2K6QKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
messages: Membrane
messages: dendrite

61622:PADI1
gene id: 61622:PADI1
uniprot id: A0A2K6PNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61622:MMUT
gene id: 61622:MMUT
uniprot id: A0A2K6NQD7
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

61622:MED21
gene id: 61622:MED21
uniprot id: A0A2K6QC08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61622:LOC104680852
gene id: 61622:LOC104680852
uniprot id: A0A2K6QEY0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

61622:CRK
gene id: 61622:CRK
uniprot id: A0A2K6Q388
names: Similarity
messages: Belongs to the CRK family.

61622:ARAF
gene id: 61622:ARAF
uniprot id: A0A2K6RFI7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

61622:MLN
gene id: 61622:MLN
uniprot id: A0A2K6NRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

61622:SH3GL1
gene id: 61622:SH3GL1
uniprot id: A0A2K6QWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

61622:STS
gene id: 61622:STS
uniprot id: A0A2K6QU43
names: Similarity
messages: Belongs to the sulfatase family.

61622:NQO1
gene id: 61622:NQO1
uniprot id: A0A2K6RLR8
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

61622:LOC104660643
gene id: 61622:LOC104660643
uniprot id: A0A2K6NHN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61622:MCU
gene id: 61622:MCU
uniprot id: A0A2K6RQ21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

61622:EIF4A2
gene id: 61622:EIF4A2
uniprot id: A0A2K6PQM1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

61622:KCNJ3
gene id: 61622:KCNJ3
uniprot id: A0A2K6N7J1
uniprot id: A0A2K6N7J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

61622:TFAP2C
gene id: 61622:TFAP2C
uniprot id: A0A2K6R0Y5
names: Similarity
messages: Belongs to the AP-2 family.

61622:ELMO1
gene id: 61622:ELMO1
uniprot id: A0A2K6R663
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

61622:ACOX3
gene id: 61622:ACOX3
uniprot id: A0A2K6R320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61622:CASP9
gene id: 61622:CASP9
uniprot id: A0A2K6R5Q8
uniprot id: A0A2K6R5R4
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:ABCG2
gene id: 61622:ABCG2
uniprot id: A0A2K6NV86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61622:HNRNPK
gene id: 61622:HNRNPK
uniprot id: A0A2K6PEY0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

61622:LOC104663490
gene id: 61622:LOC104663490
uniprot id: A0A2K6NJG1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:DMRTA1
gene id: 61622:DMRTA1
uniprot id: A0A2K6PV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:DCLRE1B
gene id: 61622:DCLRE1B
uniprot id: A0A2K6QP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

61622:DNPEP
gene id: 61622:DNPEP
uniprot id: A0A2K6RAB0
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

61622:CSNK2A1
gene id: 61622:CSNK2A1
uniprot id: A0A2K6RBA3
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TOMM40L
gene id: 61622:TOMM40L
uniprot id: A0A2K6RQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:GTF2H3
gene id: 61622:GTF2H3
uniprot id: A0A2K6P1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

61622:EIF2B4
gene id: 61622:EIF2B4
uniprot id: A0A2K6RJT2
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

61622:AVPI1
gene id: 61622:AVPI1
uniprot id: A0A2K6RCX9
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

61622:GSDMD
gene id: 61622:GSDMD
uniprot id: A0A2K6PPN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61622:DPP4
gene id: 61622:DPP4
uniprot id: A0A2K6RP32
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

61622:ATF7IP
gene id: 61622:ATF7IP
uniprot id: A0A2K6QJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

61622:UBE2K
gene id: 61622:UBE2K
uniprot id: A0A2K6PAJ0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:ATP6V1C1
gene id: 61622:ATP6V1C1
uniprot id: A0A2K6Q7C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

61622:TMA16
gene id: 61622:TMA16
uniprot id: A0A2K6PFK6
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

61622:NKIRAS2
gene id: 61622:NKIRAS2
uniprot id: A0A2K6P7A1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

61622:HOXA6
gene id: 61622:HOXA6
uniprot id: A0A2K6QA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:ITPR3
gene id: 61622:ITPR3
uniprot id: A0A2K6R3W2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

61622:TM4SF4
gene id: 61622:TM4SF4
uniprot id: A0A2K6NEB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:SLC35F6
gene id: 61622:SLC35F6
uniprot id: A0A2K6PKL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

61622:USP13
gene id: 61622:USP13
uniprot id: A0A2K6RTY3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:GPAT2
gene id: 61622:GPAT2
uniprot id: A0A2K6Q6H0
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

61622:DPRX
gene id: 61622:DPRX
uniprot id: A0A2K6REF4
names: Subcellular Location Annotation
messages: Nucleus

61622:VWCE
gene id: 61622:VWCE
uniprot id: A0A2K6PEH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DCBLD2
gene id: 61622:DCBLD2
uniprot id: A0A2K6NGH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LYVE1
gene id: 61622:LYVE1
uniprot id: A0A2K6RQB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MFAP5
gene id: 61622:MFAP5
uniprot id: A0A2K6NCV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

61622:POLR2A
gene id: 61622:POLR2A
uniprot id: A0A2K6P1E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

61622:FAM126B
gene id: 61622:FAM126B
uniprot id: A0A2K6N9I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

61622:DUSP27
gene id: 61622:DUSP27
uniprot id: A0A2K6PKY4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61622:TBCCD1
gene id: 61622:TBCCD1
uniprot id: A0A2K6REP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

61622:ABCC3
gene id: 61622:ABCC3
uniprot id: A0A2K6QW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:SLC6A4
gene id: 61622:SLC6A4
uniprot id: A0A2K6R6F6
uniprot id: A0A2K6R6G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

61622:STK38L
gene id: 61622:STK38L
uniprot id: A0A2K6P384
uniprot id: A0A2K6P387
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:ESRRG
gene id: 61622:ESRRG
uniprot id: A0A2K6QJR9
uniprot id: A0A2K6QJS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61622:CAMTA2
gene id: 61622:CAMTA2
uniprot id: A0A2K6QI41
uniprot id: A0A2K6QI48
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

61622:CIAO2B
gene id: 61622:CIAO2B
uniprot id: A0A2K6RQ59
names: Similarity
messages: Belongs to the MIP18 family.

61622:OGN
gene id: 61622:OGN
uniprot id: A0A2K6P660
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

61622:GOSR2
gene id: 61622:GOSR2
uniprot id: A0A2K6PJ94
uniprot id: A0A2K6PJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

61622:RP2
gene id: 61622:RP2
uniprot id: A0A2K6R4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

61622:BAK1
gene id: 61622:BAK1
uniprot id: A0A2K6N8B6
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:PCMTD1
gene id: 61622:PCMTD1
uniprot id: A0A2K6PTS0
uniprot id: A0A2K6PTS7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:ABCC5
gene id: 61622:ABCC5
uniprot id: A0A2K6RP44
uniprot id: A0A2K6RP66
names: Subcellular Location Annotation
messages: Membrane

61622:PIGC
gene id: 61622:PIGC
uniprot id: A0A2K6NH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

61622:MFSD6
gene id: 61622:MFSD6
uniprot id: A0A2K6RGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

61622:ZKSCAN2
gene id: 61622:ZKSCAN2
uniprot id: A0A2K6NCH3
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:HEXIM1
gene id: 61622:HEXIM1
uniprot id: A0A2K6NG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

61622:TNC
gene id: 61622:TNC
uniprot id: A0A2K6NME5
uniprot id: A0A2K6NME8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:PHKG1
gene id: 61622:PHKG1
uniprot id: A0A2K6PUN2
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

61622:NOS2
gene id: 61622:NOS2
uniprot id: A0A2K6NEP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

61622:GALNS
gene id: 61622:GALNS
uniprot id: A0A2K6PB27
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Homodimer.
messages: Lysosome

61622:ACTN4
gene id: 61622:ACTN4
uniprot id: A0A2K6RRL9
names: Similarity
messages: Belongs to the alpha-actinin family.

61622:GFM2
gene id: 61622:GFM2
uniprot id: A0A2K6Q9F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

61622:CSF3R
gene id: 61622:CSF3R
uniprot id: A0A2K6R081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61622:KDM1B
gene id: 61622:KDM1B
uniprot id: A0A2K6P8A8
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61622:PLOD3
gene id: 61622:PLOD3
uniprot id: A0A2K6QK63
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61622:UHRF2
gene id: 61622:UHRF2
uniprot id: A0A2K6PX01
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

61622:WDYHV1
gene id: 61622:WDYHV1
uniprot id: A0A2K6PB79
uniprot id: A0A2K6PB92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

61622:PIPOX
gene id: 61622:PIPOX
uniprot id: A0A2K6NNW8
names: Similarity
messages: Belongs to the MSOX/MTOX family.

61622:LOC104659363
gene id: 61622:LOC104659363
uniprot id: A0A2K6NFY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

61622:RAB43
gene id: 61622:RAB43
uniprot id: A0A2K6P9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

61622:MED19
gene id: 61622:MED19
uniprot id: A0A2K6Q2A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:CD63
gene id: 61622:CD63
uniprot id: A0A2K6RSS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

61622:GRIK4
gene id: 61622:GRIK4
uniprot id: A0A2K6Q7V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:SLC39A3
gene id: 61622:SLC39A3
uniprot id: A0A2K6NVW9
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104682395
gene id: 61622:LOC104682395
uniprot id: A0A2K6P069
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:SLC39A14
gene id: 61622:SLC39A14
uniprot id: A0A2K6PF71
uniprot id: A0A2K6PFC3
names: Subcellular Location Annotation
messages: Membrane

61622:LAPTM4A
gene id: 61622:LAPTM4A
uniprot id: A0A2K6RWT7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61622:PDK3
gene id: 61622:PDK3
uniprot id: A0A2K6QRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:LOC104682851
gene id: 61622:LOC104682851
uniprot id: A0A2K6PBE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

61622:HSPB6
gene id: 61622:HSPB6
uniprot id: A0A2K6RK94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61622:DNAJB14
gene id: 61622:DNAJB14
uniprot id: A0A2K6NBS0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:RAB4A
gene id: 61622:RAB4A
uniprot id: A0A2K6RHT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

61622:CHMP4C
gene id: 61622:CHMP4C
uniprot id: A0A2K6PER5
names: Similarity
messages: Belongs to the SNF7 family.

61622:EDEM2
gene id: 61622:EDEM2
uniprot id: A0A2K6PPW6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:IFITM10
gene id: 61622:IFITM10
uniprot id: A0A2K6Q149
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:CCNL1
gene id: 61622:CCNL1
uniprot id: A0A2K6PWX9
names: Similarity
messages: Belongs to the cyclin family.

61622:E2F6
gene id: 61622:E2F6
uniprot id: A0A2K6QL67
uniprot id: A0A2K6QL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:LOC104673586
gene id: 61622:LOC104673586
uniprot id: A0A2K6QY98
uniprot id: A0A2K6QYB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:ATG4D
gene id: 61622:ATG4D
uniprot id: A0A2K6R5R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

61622:QTRT1
gene id: 61622:QTRT1
uniprot id: A0A2K6QA99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

61622:LTA4H
gene id: 61622:LTA4H
uniprot id: A0A2K6QQB0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

61622:AGXT
gene id: 61622:AGXT
uniprot id: A0A2K6R8V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

61622:PTDSS2
gene id: 61622:PTDSS2
uniprot id: A0A2K6Q6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LHB
gene id: 61622:LHB
uniprot id: A0A2K6QCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

61622:TAAR5
gene id: 61622:TAAR5
uniprot id: A0A2K6NAM7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SAR1A
gene id: 61622:SAR1A
uniprot id: A0A2K6RLV2
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

61622:LOC104682176
gene id: 61622:LOC104682176
uniprot id: A0A2K6N840
names: Similarity
messages: Belongs to the ATG8 family.

61622:PLSCR1
gene id: 61622:PLSCR1
uniprot id: A0A2K6QJC1
uniprot id: A0A2K6QJD0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:DDI1
gene id: 61622:DDI1
uniprot id: A0A2K6NJA0
names: Similarity
messages: Belongs to the DDI1 family.

61622:PPP2R5D
gene id: 61622:PPP2R5D
uniprot id: A0A2K6R5W8
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:HOXD12
gene id: 61622:HOXD12
uniprot id: A0A2K6RFY7
names: Subcellular Location Annotation
messages: Nucleus

61622:MDM2
gene id: 61622:MDM2
uniprot id: A0A2K6RWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

61622:EDN3
gene id: 61622:EDN3
uniprot id: A0A2K6R2B3
uniprot id: A0A2K6R2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

61622:PLPP1
gene id: 61622:PLPP1
uniprot id: A0A2K6QVG0
uniprot id: A0A2K6QVH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:IL15
gene id: 61622:IL15
uniprot id: A0A2K6PYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

61622:IL17RB
gene id: 61622:IL17RB
uniprot id: A0A2K6NZC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:ACSL1
gene id: 61622:ACSL1
uniprot id: A0A2K6R4Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

61622:ZNRD1
gene id: 61622:ZNRD1
uniprot id: A0A2K6QK90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

61622:RNF4
gene id: 61622:RNF4
uniprot id: A0A2K6QNA1
names: Subcellular Location Annotation
messages: Nucleus

61622:HARBI1
gene id: 61622:HARBI1
uniprot id: A0A2K6PBY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

61622:NT5C2
gene id: 61622:NT5C2
uniprot id: A0A2K6QWE5
uniprot id: A0A2K6QWL3
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

61622:TGFB1
gene id: 61622:TGFB1
uniprot id: A0A2K6RFX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

61622:NSA2
gene id: 61622:NSA2
uniprot id: A0A2K6QI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

61622:MARK4
gene id: 61622:MARK4
uniprot id: A0A2K6RCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61622:LOC104671374
gene id: 61622:LOC104671374
uniprot id: A0A2K6NYN8
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

61622:POLD3
gene id: 61622:POLD3
uniprot id: A0A2K6R1Y3
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104660018
gene id: 61622:LOC104660018
uniprot id: A0A2K6RW52
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:HSPA9
gene id: 61622:HSPA9
uniprot id: A0A2K6Q1W7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:IDUA
gene id: 61622:IDUA
uniprot id: A0A2K6QUG4
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

61622:LCN10
gene id: 61622:LCN10
uniprot id: A0A2K6PNL2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:ANAPC16
gene id: 61622:ANAPC16
uniprot id: A0A2K6QIG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

61622:GPR180
gene id: 61622:GPR180
uniprot id: A0A2K6PHE5
names: Subcellular Location Annotation
messages: Membrane

61622:SLC25A17
gene id: 61622:SLC25A17
uniprot id: A0A2K6P6F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:HBP1
gene id: 61622:HBP1
uniprot id: A0A2K6QAH9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

61622:LOC104663512
gene id: 61622:LOC104663512
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MSR1
gene id: 61622:MSR1
uniprot id: A0A2K6N8I5
names: Subcellular Location Annotation
messages: Membrane

61622:BRPF1
gene id: 61622:BRPF1
uniprot id: A0A2K6QWR5
uniprot id: A0A2K6QWV1
names: Subcellular Location Annotation
messages: Nucleus

61622:ARCN1
gene id: 61622:ARCN1
uniprot id: A0A2K6RKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61622:SPTLC2
gene id: 61622:SPTLC2
uniprot id: A0A2K6R372
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

61622:DOK3
gene id: 61622:DOK3
uniprot id: A0A2K6PRW2
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

61622:MPP7
gene id: 61622:MPP7
uniprot id: A0A2K6PD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

61622:DLGAP5
gene id: 61622:DLGAP5
uniprot id: A0A2K6Q7Z9
uniprot id: A0A2K6Q811
names: Similarity
messages: Belongs to the SAPAP family.

61622:MRPS11
gene id: 61622:MRPS11
uniprot id: A0A2K6PLR5
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

61622:PSME3IP1
gene id: 61622:PSME3IP1
uniprot id: A0A2K6PZX7
names: Subcellular Location Annotation
messages: Nucleus

61622:TRAM2
gene id: 61622:TRAM2
uniprot id: A0A2K6Q6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61622:SPIN4
gene id: 61622:SPIN4
uniprot id: A0A2K6NCK0
names: Similarity
messages: Belongs to the SPIN/STSY family.

61622:GAR1
gene id: 61622:GAR1
uniprot id: A0A2K6NV08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

61622:EML6
gene id: 61622:EML6
uniprot id: A0A2K6R556
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

61622:CHDH
gene id: 61622:CHDH
uniprot id: A0A2K6PEV1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

61622:KCNS2
gene id: 61622:KCNS2
uniprot id: A0A2K6NR70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TPM4
gene id: 61622:TPM4
uniprot id: A0A2K6Q9T1
uniprot id: A0A2K6Q9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:PSMA3
gene id: 61622:PSMA3
uniprot id: A0A2K6QZT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:LYRM9
gene id: 61622:LYRM9
uniprot id: A0A2K6PMM9
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

61622:MERTK
gene id: 61622:MERTK
uniprot id: A0A2K6RNA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

61622:CLPTM1
gene id: 61622:CLPTM1
uniprot id: A0A2K6P8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

61622:TSR3
gene id: 61622:TSR3
uniprot id: A0A2K6RB65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HNRNPR
gene id: 61622:HNRNPR
uniprot id: A0A2K6QCE9
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ALDH3A2
gene id: 61622:ALDH3A2
uniprot id: A0A2K6QD73
uniprot id: A0A2K6QD74
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:GPSM2
gene id: 61622:GPSM2
uniprot id: A0A2K6QJ14
names: Similarity
messages: Belongs to the GPSM family.

61622:ADAMTS20
gene id: 61622:ADAMTS20
uniprot id: A0A2K6QXR7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:USP44
gene id: 61622:USP44
uniprot id: A0A2K6NSG7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:CLDN8
gene id: 61622:CLDN8
uniprot id: A0A2K6NU33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:ARGLU1
gene id: 61622:ARGLU1
uniprot id: A0A2K6NCU6
names: Similarity
messages: Belongs to the UPF0430 family.

61622:MCOLN1
gene id: 61622:MCOLN1
uniprot id: A0A2K6RUU1
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:AP2A1
gene id: 61622:AP2A1
uniprot id: A0A2K6QU23
uniprot id: A0A2K6QU67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

61622:BMP15
gene id: 61622:BMP15
uniprot id: A0A2K6QQR3
names: Similarity
messages: Belongs to the TGF-beta family.

61622:COPZ2
gene id: 61622:COPZ2
uniprot id: A0A2K6PA98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

61622:ACTA2
gene id: 61622:ACTA2
uniprot id: A0A2K6PUD3
names: Similarity
messages: Belongs to the actin family.

61622:SPON1
gene id: 61622:SPON1
uniprot id: A0A2K6RW08
names: Subcellular Location Annotation
messages: extracellular matrix

61622:IFNB1
gene id: 61622:IFNB1
uniprot id: A0A2K6N8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61622:SDHAF2
gene id: 61622:SDHAF2
uniprot id: A0A2K6QHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

61622:TIMM17B
gene id: 61622:TIMM17B
uniprot id: A0A2K6RG65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61622:KATNAL1
gene id: 61622:KATNAL1
uniprot id: A0A2K6PWY3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

61622:FLNA
gene id: 61622:FLNA
uniprot id: A0A2K6R5A8
uniprot id: A0A2K6R5B0
names: Similarity
messages: Belongs to the filamin family.

61622:FUCA2
gene id: 61622:FUCA2
uniprot id: A0A2K6P6L8
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

61622:SDHAF3
gene id: 61622:SDHAF3
uniprot id: A0A2K6P4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

61622:ASIC5
gene id: 61622:ASIC5
uniprot id: A0A2K6NNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

61622:SELENBP1
gene id: 61622:SELENBP1
uniprot id: A0A2K6QEB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

61622:F2
gene id: 61622:F2
uniprot id: A0A2K6QIT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

61622:PAH
gene id: 61622:PAH
uniprot id: A0A2K6QV60
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

61622:LOC104672980
gene id: 61622:LOC104672980
uniprot id: A0A2K6NUM5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:CASP14
gene id: 61622:CASP14
uniprot id: A0A2K6R5W4
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:SLC8A3
gene id: 61622:SLC8A3
uniprot id: A0A2K6NSH5
uniprot id: A0A2K6NSI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

61622:PSMD12
gene id: 61622:PSMD12
uniprot id: A0A2K6RAF5
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

61622:CCL15
gene id: 61622:CCL15
uniprot id: A0A2K6R6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:RPL31
gene id: 61622:RPL31
uniprot id: A0A2K6NEN8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

61622:FECH
gene id: 61622:FECH
uniprot id: A0A2K6P7J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

61622:PSMB10
gene id: 61622:PSMB10
uniprot id: A0A2K6N9Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:ATP5IF1
gene id: 61622:ATP5IF1
uniprot id: A0A2K6Q8H8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

61622:FAM114A2
gene id: 61622:FAM114A2
uniprot id: A0A2K6NR93
names: Similarity
messages: Belongs to the FAM114 family.

61622:SUCLA2
gene id: 61622:SUCLA2
uniprot id: A0A2K6NJ74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

61622:ELAC1
gene id: 61622:ELAC1
uniprot id: A0A2K6QFU5
names: Subunit
messages: Homodimer.

61622:ADGRG4
gene id: 61622:ADGRG4
uniprot id: A0A2K6NZ26
uniprot id: A0A2K6NZ36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PRDX5
gene id: 61622:PRDX5
uniprot id: A0A2K6NLQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

61622:PSD
gene id: 61622:PSD
uniprot id: A0A2K6R3V0
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

61622:NOP2
gene id: 61622:NOP2
uniprot id: A0A2K6R1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

61622:TFCP2
gene id: 61622:TFCP2
uniprot id: A0A2K6QDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:MKNK1
gene id: 61622:MKNK1
uniprot id: A0A2K6QUM7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TPI1
gene id: 61622:TPI1
uniprot id: A0A2K6RUD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

61622:EXOSC7
gene id: 61622:EXOSC7
uniprot id: A0A2K6QIV8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ADD2
gene id: 61622:ADD2
uniprot id: A0A2K6R1P9
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

61622:EGR2
gene id: 61622:EGR2
uniprot id: A0A2K6RC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

61622:S100A5
gene id: 61622:S100A5
uniprot id: A0A2K6Q2G5
names: Similarity
messages: Belongs to the S-100 family.

61622:NXF3
gene id: 61622:NXF3
uniprot id: A0A2K6PDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

61622:RPS7
gene id: 61622:RPS7
uniprot id: A0A2K6QX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

61622:ATAT1
gene id: 61622:ATAT1
uniprot id: A0A2K6R0G7
uniprot id: A0A2K6R0H2
uniprot id: A0A2K6R0H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

61622:LOC104669807
gene id: 61622:LOC104669807
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:GPRC5B
gene id: 61622:GPRC5B
uniprot id: A0A2K6RJZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:RPL9
gene id: 61622:RPL9
uniprot id: A0A2K6NGZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61622:LOC104670633
gene id: 61622:LOC104670633
uniprot id: A0A2K6PY32
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PORCN
gene id: 61622:PORCN
uniprot id: A0A2K6PZJ0
uniprot id: A0A2K6PZK7
names: Subcellular Location Annotation
messages: Membrane

61622:CENPN
gene id: 61622:CENPN
uniprot id: A0A2K6NBU9
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

61622:DHX15
gene id: 61622:DHX15
uniprot id: A0A2K6QPY4
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

61622:GORASP2
gene id: 61622:GORASP2
uniprot id: A0A2K6PYS3
names: Similarity
messages: Belongs to the GORASP family.

61622:CYSTM1
gene id: 61622:CYSTM1
uniprot id: A0A2K6QAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

61622:ELF3
gene id: 61622:ELF3
uniprot id: A0A2K6QTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:LOC104658973
gene id: 61622:LOC104658973
uniprot id: A0A2K6NDQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:HEXB
gene id: 61622:HEXB
uniprot id: A0A2K6RB47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

61622:ACTL10
gene id: 61622:ACTL10
uniprot id: A0A2K6NDK2
names: Similarity
messages: Belongs to the actin family.

61622:CD99
gene id: 61622:CD99
uniprot id: A0A2K6NM71
names: Similarity
messages: Belongs to the CD99 family.

61622:SMARCB1
gene id: 61622:SMARCB1
uniprot id: A0A2K6P8N0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

61622:CLP1
gene id: 61622:CLP1
uniprot id: A0A2K6QQQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

61622:CFAP299
gene id: 61622:CFAP299
uniprot id: A0A2K6PAH1
uniprot id: A0A2K6PAJ6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

61622:COQ10A
gene id: 61622:COQ10A
uniprot id: A0A2K6Q6T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

61622:LOC104678031
gene id: 61622:LOC104678031
uniprot id: A0A2K6QBC8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PIK3CB
gene id: 61622:PIK3CB
uniprot id: A0A2K6RRD5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:GSX2
gene id: 61622:GSX2
uniprot id: A0A2K6P2W4
names: Subcellular Location Annotation
messages: Nucleus

61622:MICOS13
gene id: 61622:MICOS13
uniprot id: A0A2K6PEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ITPKB
gene id: 61622:ITPKB
uniprot id: A0A2K6PTW3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:PLSCR3
gene id: 61622:PLSCR3
uniprot id: A0A2K6Q7G5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:DHH
gene id: 61622:DHH
uniprot id: A0A2K6PZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

61622:TPM1
gene id: 61622:TPM1
uniprot id: A0A2K6NW93
uniprot id: A0A2K6NW95
uniprot id: A0A2K6NWA5
uniprot id: A0A2K6NWB5
uniprot id: A0A2K6NWB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:ZDHHC16
gene id: 61622:ZDHHC16
uniprot id: A0A2K6NV90
uniprot id: A0A2K6NVA1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104677241
gene id: 61622:LOC104677241
uniprot id: A0A2K6N8G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GADD45G
gene id: 61622:GADD45G
uniprot id: A0A2K6QPC4
names: Similarity
messages: Belongs to the GADD45 family.

61622:LOC104664349
gene id: 61622:LOC104664349
uniprot id: A0A2K6NDE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

61622:TUBGCP3
gene id: 61622:TUBGCP3
uniprot id: A0A2K6RDA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61622:CRTC2
gene id: 61622:CRTC2
uniprot id: A0A2K6QNF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

61622:MOV10
gene id: 61622:MOV10
uniprot id: A0A2K6R2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

61622:LOC104680972
gene id: 61622:LOC104680972
uniprot id: A0A2K6NU84
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:OXSM
gene id: 61622:OXSM
uniprot id: A0A2K6N970
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

61622:GABRR1
gene id: 61622:GABRR1
uniprot id: A0A2K6PAH9
uniprot id: A0A2K6PAI1
uniprot id: A0A2K6PAN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LOC104673588
gene id: 61622:LOC104673588
uniprot id: A0A2K6Q8K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:ADGRL2
gene id: 61622:ADGRL2
uniprot id: A0A2K6Q7L4
uniprot id: A0A2K6Q7L8
names: Subcellular Location Annotation
messages: Membrane

61622:STX5
gene id: 61622:STX5
uniprot id: A0A2K6P210
names: Similarity
messages: Belongs to the syntaxin family.

61622:ATP2B4
gene id: 61622:ATP2B4
uniprot id: A0A2K6NDX9
uniprot id: A0A2K6NDZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104664941
gene id: 61622:LOC104664941
uniprot id: A0A2K6QLJ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:SGSH
gene id: 61622:SGSH
uniprot id: A0A2K6QMU5
names: Similarity
messages: Belongs to the sulfatase family.

61622:ETV4
gene id: 61622:ETV4
uniprot id: A0A2K6P6T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:ID3
gene id: 61622:ID3
uniprot id: A0A2K6NQZ8
names: Subcellular Location Annotation
messages: Nucleus

61622:EFNA4
gene id: 61622:EFNA4
uniprot id: A0A2K6RPU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PDE2A
gene id: 61622:PDE2A
uniprot id: A0A2K6R893
uniprot id: A0A2K6R8D2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:EXOSC9
gene id: 61622:EXOSC9
uniprot id: A0A2K6R0G1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LOC104670102
gene id: 61622:LOC104670102
uniprot id: A0A2K6QKI2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:WNT11
gene id: 61622:WNT11
uniprot id: A0A2K6PAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:TIMM17A
gene id: 61622:TIMM17A
uniprot id: A0A2K6RIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61622:PNN
gene id: 61622:PNN
uniprot id: A0A2K6NSQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

61622:MYO1D
gene id: 61622:MYO1D
uniprot id: A0A2K6Q8I4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:NMD3
gene id: 61622:NMD3
uniprot id: A0A2K6Q7M9
uniprot id: A0A2K6Q7N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

61622:PEBP1
gene id: 61622:PEBP1
uniprot id: A0A2K6NU87
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

61622:LOC104664036
gene id: 61622:LOC104664036
uniprot id: A0A2K6NF24
uniprot id: A0A2K6QLG0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:SEPTIN4
gene id: 61622:SEPTIN4
uniprot id: A0A2K6PG27
uniprot id: A0A2K6PG30
uniprot id: A0A2K6PG80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:LOC104656300
gene id: 61622:LOC104656300
uniprot id: A0A2K6NAL7
names: Subcellular Location Annotation
messages: Membrane

61622:PPP1R16B
gene id: 61622:PPP1R16B
uniprot id: A0A2K6Q8B2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CBX5
gene id: 61622:CBX5
uniprot id: A0A2K6QYW9
names: Subcellular Location Annotation
messages: Nucleus

61622:TMPRSS2
gene id: 61622:TMPRSS2
uniprot id: A0A2K6PKH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GPR25
gene id: 61622:GPR25
uniprot id: A0A2K6NFN6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PRRC1
gene id: 61622:PRRC1
uniprot id: A0A2K6PNM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

61622:BTG4
gene id: 61622:BTG4
uniprot id: A0A2K6NU60
names: Similarity
messages: Belongs to the BTG family.

61622:SLC37A4
gene id: 61622:SLC37A4
uniprot id: A0A2K6Q0M0
uniprot id: A0A2K6Q0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

61622:ESCO1
gene id: 61622:ESCO1
uniprot id: A0A2K6R0S7
names: Subcellular Location Annotation
messages: Nucleus

61622:PPP5C
gene id: 61622:PPP5C
uniprot id: A0A2K6NSR5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

61622:BCL2L1
gene id: 61622:BCL2L1
uniprot id: A0A2K6QFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

61622:IARS2
gene id: 61622:IARS2
uniprot id: A0A2K6NGE6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:RTCA
gene id: 61622:RTCA
uniprot id: A0A2K6NPQ1
uniprot id: A0A2K6NPQ7
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

61622:ABHD3
gene id: 61622:ABHD3
uniprot id: A0A2K6PXV7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

61622:MEOX2
gene id: 61622:MEOX2
uniprot id: A0A2K6Q3P4
names: Subcellular Location Annotation
messages: Nucleus

61622:PSMD7
gene id: 61622:PSMD7
uniprot id: A0A2K6P4D3
names: Similarity
messages: Belongs to the peptidase M67A family.

61622:GTDC1
gene id: 61622:GTDC1
uniprot id: A0A2K6PI54
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

61622:KIFC3
gene id: 61622:KIFC3
uniprot id: A0A2K6P9F3
uniprot id: A0A2K6P9L0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:PTGER4
gene id: 61622:PTGER4
uniprot id: A0A2K6PV71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

61622:SLC25A1
gene id: 61622:SLC25A1
uniprot id: A0A2K6RVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:PANX3
gene id: 61622:PANX3
uniprot id: A0A2K6PEF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61622:TBX5
gene id: 61622:TBX5
uniprot id: A0A2K6QYD1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:RPL24
gene id: 61622:RPL24
uniprot id: A0A2K6RVF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61622:NDP
gene id: 61622:NDP
uniprot id: A0A2K6PPV1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:NSMCE1
gene id: 61622:NSMCE1
uniprot id: A0A2K6P830
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

61622:SLC19A1
gene id: 61622:SLC19A1
uniprot id: A0A2K6PLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

61622:DNTTIP1
gene id: 61622:DNTTIP1
uniprot id: A0A2K6P8G4
names: Subcellular Location Annotation
messages: Nucleus

61622:PSMD5
gene id: 61622:PSMD5
uniprot id: A0A2K6P1M9
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

61622:POLH
gene id: 61622:POLH
uniprot id: A0A2K6Q905
names: Subcellular Location Annotation
messages: Nucleus

61622:IAH1
gene id: 61622:IAH1
uniprot id: A0A2K6PUW7
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

61622:PPP1R10
gene id: 61622:PPP1R10
uniprot id: A0A2K6Q850
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

61622:EIF4ENIF1
gene id: 61622:EIF4ENIF1
uniprot id: A0A2K6P317
uniprot id: A0A2K6P336
names: Subcellular Location Annotation
messages: Cytoplasm

61622:RTN4IP1
gene id: 61622:RTN4IP1
uniprot id: A0A2K6Q1R1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61622:CTC1
gene id: 61622:CTC1
uniprot id: A0A2K6NIU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

61622:DDX47
gene id: 61622:DDX47
uniprot id: A0A2K6NPU0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

61622:SMAD4
gene id: 61622:SMAD4
uniprot id: A0A2K6RQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

61622:LOC104670107
gene id: 61622:LOC104670107
uniprot id: A0A2K6NCL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:PLIN5
gene id: 61622:PLIN5
uniprot id: A0A2K6RM31
names: Similarity
messages: Belongs to the perilipin family.

61622:LEPROTL1
gene id: 61622:LEPROTL1
uniprot id: A0A2K6NZV3
uniprot id: A0A2K6NZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

61622:MRAP
gene id: 61622:MRAP
uniprot id: A0A2K6QGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104677181
gene id: 61622:LOC104677181
uniprot id: A0A2K6RDU9
names: Similarity
messages: Belongs to the SPAN-X family.

61622:SEPSECS
gene id: 61622:SEPSECS
uniprot id: A0A2K6NMC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

61622:LOC104682087
gene id: 61622:LOC104682087
uniprot id: A0A2K6QGW4
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:IMPDH1
gene id: 61622:IMPDH1
uniprot id: A0A2K6RVE5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

61622:ASIP
gene id: 61622:ASIP
uniprot id: A0A2K6RSW9
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Secreted

61622:MAPRE2
gene id: 61622:MAPRE2
uniprot id: A0A2K6PXA4
uniprot id: A0A2K6PXB8
uniprot id: A0A2K6PXC1
uniprot id: A0A2K6PXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

61622:NECAP2
gene id: 61622:NECAP2
uniprot id: A0A2K6P4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

61622:CLCN4
gene id: 61622:CLCN4
uniprot id: A0A2K6NR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

61622:BOLA2B
gene id: 61622:BOLA2B
uniprot id: A0A2K6R415
names: Similarity
messages: Belongs to the BolA/IbaG family.

61622:GTF2E2
gene id: 61622:GTF2E2
uniprot id: A0A2K6RBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

61622:PSMB5
gene id: 61622:PSMB5
uniprot id: A0A2K6PUQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:BBS7
gene id: 61622:BBS7
uniprot id: A0A2K6NGH9
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

61622:GIPR
gene id: 61622:GIPR
uniprot id: A0A2K6PCE6
names: Subcellular Location Annotation
messages: Membrane

61622:VRK1
gene id: 61622:VRK1
uniprot id: A0A2K6PNE5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TMED10
gene id: 61622:TMED10
uniprot id: A0A2K6PUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:C4H6orf89
gene id: 61622:C4H6orf89
uniprot id: A0A2K6R7D8
uniprot id: A0A2K6R7E3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61622:TSR1
gene id: 61622:TSR1
uniprot id: A0A2K6P6A1
names: Subcellular Location Annotation
messages: nucleolus

61622:TNNI3
gene id: 61622:TNNI3
uniprot id: A0A2K6RCK6
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61622:LOC104657206
gene id: 61622:LOC104657206
uniprot id: A0A2K6N9R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ANXA7
gene id: 61622:ANXA7
uniprot id: A0A2K6QHP4
uniprot id: A0A2K6QHP6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61622:RFC5
gene id: 61622:RFC5
uniprot id: A0A2K6QWG2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

61622:IL2RB
gene id: 61622:IL2RB
uniprot id: A0A2K6RLB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

61622:C4BPB
gene id: 61622:C4BPB
uniprot id: A0A2K6PRB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ISY1
gene id: 61622:ISY1
uniprot id: A0A2K6PIH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

61622:LOC104656071
gene id: 61622:LOC104656071
uniprot id: A0A2K6N7V8
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

61622:EIF5A2
gene id: 61622:EIF5A2
uniprot id: A0A2K6R7R5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

61622:FGF17
gene id: 61622:FGF17
uniprot id: A0A2K6QFZ3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:PIP4P1
gene id: 61622:PIP4P1
uniprot id: A0A2K6PCT4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

61622:THAP1
gene id: 61622:THAP1
uniprot id: A0A2K6R8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

61622:HTRA4
gene id: 61622:HTRA4
uniprot id: A0A2K6QLT8
names: Similarity
messages: Belongs to the peptidase S1C family.

61622:ATP6V0A2
gene id: 61622:ATP6V0A2
uniprot id: A0A2K6RLL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61622:C4BPA
gene id: 61622:C4BPA
uniprot id: A0A2K6QCS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GINS1
gene id: 61622:GINS1
uniprot id: A0A2K6Q6X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

61622:SLC1A3
gene id: 61622:SLC1A3
uniprot id: A0A2K6QFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61622:GABPA
gene id: 61622:GABPA
uniprot id: A0A2K6PVZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:GORASP1
gene id: 61622:GORASP1
uniprot id: A0A2K6RT81
names: Similarity
messages: Belongs to the GORASP family.

61622:CHST11
gene id: 61622:CHST11
uniprot id: A0A2K6R880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:FBXO25
gene id: 61622:FBXO25
uniprot id: A0A2K6NIL9
uniprot id: A0A2K6NIN7
names: Subcellular Location Annotation
messages: Nucleus

61622:NUMBL
gene id: 61622:NUMBL
uniprot id: A0A2K6R5X2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a role in the process of neurogenesis.

61622:GOLT1B
gene id: 61622:GOLT1B
uniprot id: A0A2K6NEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61622:ST14
gene id: 61622:ST14
uniprot id: A0A2K6RHB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ACTR1A
gene id: 61622:ACTR1A
uniprot id: A0A2K6QRM1
names: Similarity
messages: Belongs to the actin family.

61622:MDGA1
gene id: 61622:MDGA1
uniprot id: A0A2K6P215
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PSAP
gene id: 61622:PSAP
uniprot id: A0A2K6PRY0
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

61622:PCK2
gene id: 61622:PCK2
uniprot id: A0A2K6NC65
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

61622:RPS26
gene id: 61622:RPS26
uniprot id: A0A2K6QFN4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61622:IQCG
gene id: 61622:IQCG
uniprot id: A0A2K6N888
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

61622:SPP1
gene id: 61622:SPP1
uniprot id: A0A2K6QIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

61622:TWF1
gene id: 61622:TWF1
uniprot id: A0A2K6QNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

61622:RAG2
gene id: 61622:RAG2
uniprot id: A0A2K6N9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

61622:ATP6V1C2
gene id: 61622:ATP6V1C2
uniprot id: A0A2K6QQD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

61622:DESI2
gene id: 61622:DESI2
uniprot id: A0A2K6QAQ6
uniprot id: A0A2K6QAR0
names: Similarity
messages: Belongs to the DeSI family.

61622:QPCT
gene id: 61622:QPCT
uniprot id: A0A2K6PTL2
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

61622:RAB33B
gene id: 61622:RAB33B
uniprot id: A0A2K6PTX4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

61622:ABL1
gene id: 61622:ABL1
uniprot id: A0A2K6PIM2
uniprot id: A0A2K6PIP4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:LOC104676853
gene id: 61622:LOC104676853
uniprot id: A0A2K6NUI5
names: Subcellular Location Annotation
messages: Membrane

61622:VLDLR
gene id: 61622:VLDLR
uniprot id: A0A2K6PNB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GATC
gene id: 61622:GATC
uniprot id: A0A2K6RCV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

61622:MMP7
gene id: 61622:MMP7
uniprot id: A0A2K6RP75
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:GSDMC
gene id: 61622:GSDMC
uniprot id: A0A2K6QPT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61622:LOC104675385
gene id: 61622:LOC104675385
uniprot id: A0A2K6NWU6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61622:ACTL8
gene id: 61622:ACTL8
uniprot id: A0A2K6QFB3
names: Similarity
messages: Belongs to the actin family.

61622:FAM189B
gene id: 61622:FAM189B
uniprot id: A0A2K6PQK2
uniprot id: A0A2K6PQK5
names: Similarity
messages: Belongs to the ENTREP family.

61622:SMOC1
gene id: 61622:SMOC1
uniprot id: A0A2K6NQI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CALHM3
gene id: 61622:CALHM3
uniprot id: A0A2K6NE09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61622:ILDR2
gene id: 61622:ILDR2
uniprot id: A0A2K6R2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

61622:RBFOX1
gene id: 61622:RBFOX1
uniprot id: A0A2K6RNH3
uniprot id: A0A2K6RNH6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

61622:HBS1L
gene id: 61622:HBS1L
uniprot id: A0A2K6NR58
uniprot id: A0A2K6NR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

61622:CSTF1
gene id: 61622:CSTF1
uniprot id: A0A2K6NBP7
names: Subcellular Location Annotation
messages: Nucleus

61622:ANXA1
gene id: 61622:ANXA1
uniprot id: A0A2K6RAX8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

61622:GALK1
gene id: 61622:GALK1
uniprot id: A0A2K6NWI5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

61622:SLC39A13
gene id: 61622:SLC39A13
uniprot id: A0A2K6QKU1
names: Subcellular Location Annotation
messages: Membrane

61622:BORCS5
gene id: 61622:BORCS5
uniprot id: A0A2K6RUT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

61622:MRPS25
gene id: 61622:MRPS25
uniprot id: A0A2K6PYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

61622:DNAJC2
gene id: 61622:DNAJC2
uniprot id: A0A2K6P3I0
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

61622:GLMP
gene id: 61622:GLMP
uniprot id: A0A2K6P4T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

61622:IMPA1
gene id: 61622:IMPA1
uniprot id: A0A2K6ND23
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:PTPN6
gene id: 61622:PTPN6
uniprot id: A0A2K6QK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

61622:PTPRK
gene id: 61622:PTPRK
uniprot id: A0A2K6R0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

61622:TACC3
gene id: 61622:TACC3
uniprot id: A0A2K6QPY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

61622:MYH9
gene id: 61622:MYH9
uniprot id: A0A2K6P6S8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:TNKS2
gene id: 61622:TNKS2
uniprot id: A0A2K6QAU2
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:XPA
gene id: 61622:XPA
uniprot id: A0A2K6P3T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

61622:HSPA5
gene id: 61622:HSPA5
uniprot id: A0A2K6NWE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

61622:RXRG
gene id: 61622:RXRG
uniprot id: A0A2K6NM48
uniprot id: A0A2K6NM51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

61622:TYRO3
gene id: 61622:TYRO3
uniprot id: A0A2K6PSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

61622:NFYA
gene id: 61622:NFYA
uniprot id: A0A2K6NWZ7
uniprot id: A0A2K6NX02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

61622:LOC104672609
gene id: 61622:LOC104672609
uniprot id: A0A2K6NEJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:KCNJ15
gene id: 61622:KCNJ15
uniprot id: A0A2K6NAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:B3GNT3
gene id: 61622:B3GNT3
uniprot id: A0A2K6PPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:NHEJ1
gene id: 61622:NHEJ1
uniprot id: A0A2K6NYL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

61622:LOC104668287
gene id: 61622:LOC104668287
uniprot id: A0A2K6QZH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61622:FOXI1
gene id: 61622:FOXI1
uniprot id: A0A2K6QSM6
names: Subcellular Location Annotation
messages: Nucleus

61622:LIFR
gene id: 61622:LIFR
uniprot id: A0A2K6NTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61622:ZIC4
gene id: 61622:ZIC4
uniprot id: A0A2K6NVW7
uniprot id: A0A2K6NVW8
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

61622:NCSTN
gene id: 61622:NCSTN
uniprot id: A0A2K6PLK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

61622:VIRMA
gene id: 61622:VIRMA
uniprot id: A0A2K6QFK9
names: Similarity
messages: Belongs to the vir family.

61622:EXO5
gene id: 61622:EXO5
uniprot id: A0A2K6N9F9
names: Similarity
messages: Belongs to the EXO5 family.

61622:AVP
gene id: 61622:AVP
uniprot id: A0A2K6PBA0
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

61622:MAB21L1
gene id: 61622:MAB21L1
uniprot id: A0A2K6N9D5
names: Similarity
messages: Belongs to the mab-21 family.

61622:LOC104669273
gene id: 61622:LOC104669273
uniprot id: A0A2K6PXJ1
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61622:SERPINF2
gene id: 61622:SERPINF2
uniprot id: A0A2K6NE77
names: Similarity
messages: Belongs to the serpin family.

61622:ORAI3
gene id: 61622:ORAI3
uniprot id: A0A2K6N9Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

61622:SUPT4H1
gene id: 61622:SUPT4H1
uniprot id: A0A2K6RWX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

61622:DOCK7
gene id: 61622:DOCK7
uniprot id: A0A2K6QX99
uniprot id: A0A2K6QXA2
names: Similarity
messages: Belongs to the DOCK family.

61622:NDUFB10
gene id: 61622:NDUFB10
uniprot id: A0A2K6NAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

61622:SLC6A19
gene id: 61622:SLC6A19
uniprot id: A0A2K6QDW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:PRKCG
gene id: 61622:PRKCG
uniprot id: A0A2K6PL72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

61622:SLC2A7
gene id: 61622:SLC2A7
uniprot id: A0A2K6QDP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

61622:XAGE3
gene id: 61622:XAGE3
uniprot id: A0A2K6RS37
names: Similarity
messages: Belongs to the GAGE family.

61622:B3GNT5
gene id: 61622:B3GNT5
uniprot id: A0A2K6NCX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:S100PBP
gene id: 61622:S100PBP
uniprot id: A0A2K6QL73
names: Subcellular Location Annotation
messages: Nucleus

61622:PLP2
gene id: 61622:PLP2
uniprot id: A0A2K6PUH2
names: Subcellular Location Annotation
messages: Membrane

61622:NTRK2
gene id: 61622:NTRK2
uniprot id: A0A2K6QVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

61622:ATG16L1
gene id: 61622:ATG16L1
uniprot id: A0A2K6NRT3
uniprot id: A0A2K6NRU4
uniprot id: A0A2K6NRV1
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

61622:WDR46
gene id: 61622:WDR46
uniprot id: A0A2K6NKS6
names: Subcellular Location Annotation
messages: nucleolus

61622:SLC9A3R2
gene id: 61622:SLC9A3R2
uniprot id: A0A2K6QZG4
names: Subcellular Location Annotation
messages: Cell membrane

61622:DESI1
gene id: 61622:DESI1
uniprot id: A0A2K6QQT7
names: Similarity
messages: Belongs to the DeSI family.

61622:TRPC7
gene id: 61622:TRPC7
uniprot id: A0A2K6PGB1
uniprot id: A0A2K6PGC0
uniprot id: A0A2K6PGJ2
names: Subcellular Location Annotation
messages: Membrane

61622:ALDH5A1
gene id: 61622:ALDH5A1
uniprot id: A0A2K6NPA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

61622:RBM22
gene id: 61622:RBM22
uniprot id: A0A2K6R5N5
names: Similarity
messages: Belongs to the SLT11 family.

61622:TRNT1
gene id: 61622:TRNT1
uniprot id: A0A2K6QBT2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

61622:CLSTN2
gene id: 61622:CLSTN2
uniprot id: A0A2K6QXM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

61622:LOC104657860
gene id: 61622:LOC104657860
uniprot id: A0A2K6RXK3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:NUP107
gene id: 61622:NUP107
uniprot id: A0A2K6QWR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

61622:CAPZB
gene id: 61622:CAPZB
uniprot id: A0A2K6Q1N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

61622:SLCO5A1
gene id: 61622:SLCO5A1
uniprot id: A0A2K6NEP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NAA25
gene id: 61622:NAA25
uniprot id: A0A2K6PTT1
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

61622:JPH1
gene id: 61622:JPH1
uniprot id: A0A2K6Q163
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

61622:HIBCH
gene id: 61622:HIBCH
uniprot id: A0A2K6QAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

61622:POLR1E
gene id: 61622:POLR1E
uniprot id: A0A2K6PGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

61622:FGF6
gene id: 61622:FGF6
uniprot id: A0A2K6QUT8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:ELL2
gene id: 61622:ELL2
uniprot id: A0A2K6PX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

61622:SLCO1A2
gene id: 61622:SLCO1A2
uniprot id: A0A2K6PZQ5
uniprot id: A0A2K6PZR7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:BCAS2
gene id: 61622:BCAS2
uniprot id: A0A2K6RN21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

61622:DIAPH1
gene id: 61622:DIAPH1
uniprot id: A0A2K6Q9Z1
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

61622:RFT1
gene id: 61622:RFT1
uniprot id: A0A2K6N9D7
uniprot id: A0A2K6N9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

61622:GPR15
gene id: 61622:GPR15
uniprot id: A0A2K6NGG8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:HLF
gene id: 61622:HLF
uniprot id: A0A2K6QCG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

61622:DLX3
gene id: 61622:DLX3
uniprot id: A0A2K6NE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

61622:NSUN6
gene id: 61622:NSUN6
uniprot id: A0A2K6PS86
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61622:PLAT
gene id: 61622:PLAT
uniprot id: A0A2K6Q8B5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:TNMD
gene id: 61622:TNMD
uniprot id: A0A2K6QFC1
names: Similarity
messages: Belongs to the chondromodulin-1 family.

61622:SRY
gene id: 61622:SRY
uniprot id: I3Y1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRY family.
messages: Cytoplasm
messages: Nucleus speckle

61622:MINPP1
gene id: 61622:MINPP1
uniprot id: A0A2K6P4G9
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

61622:PRPH2
gene id: 61622:PRPH2
uniprot id: A0A2K6RAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

61622:SLC17A5
gene id: 61622:SLC17A5
uniprot id: A0A2K6PZ24
names: Subcellular Location Annotation
messages: Membrane

61622:PRR5
gene id: 61622:PRR5
uniprot id: A0A2K6NG05
names: Similarity
messages: Belongs to the PROTOR family.

61622:GLRA2
gene id: 61622:GLRA2
uniprot id: A0A2K6NY95
uniprot id: A0A2K6NY97
uniprot id: A0A2K6NYA8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

61622:SEC16A
gene id: 61622:SEC16A
uniprot id: A0A2K6RKA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

61622:NEMP1
gene id: 61622:NEMP1
uniprot id: A0A2K6PLE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

61622:LY6G5C
gene id: 61622:LY6G5C
uniprot id: A0A2K6NHU5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

61622:ARHGEF9
gene id: 61622:ARHGEF9
uniprot id: A0A2K6Q4G2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

61622:CTU1
gene id: 61622:CTU1
uniprot id: A0A2K6Q4J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

61622:LAMTOR3
gene id: 61622:LAMTOR3
uniprot id: A0A2K6PGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

61622:TMEM129
gene id: 61622:TMEM129
uniprot id: A0A2K6R530
uniprot id: A0A2K6R533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

61622:TCTA
gene id: 61622:TCTA
uniprot id: A0A2K6QKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

61622:DYNLRB1
gene id: 61622:DYNLRB1
uniprot id: A0A2K6P300
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

61622:OPTN
gene id: 61622:OPTN
uniprot id: A0A2K6RCN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

61622:EBF3
gene id: 61622:EBF3
uniprot id: A0A2K6PH48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61622:RIC3
gene id: 61622:RIC3
uniprot id: A0A2K6QMG7
names: Similarity
messages: Belongs to the ric-3 family.

61622:ACKR3
gene id: 61622:ACKR3
uniprot id: A0A2K6QF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CRMP1
gene id: 61622:CRMP1
uniprot id: A0A2K6P176
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

61622:SPPL3
gene id: 61622:SPPL3
uniprot id: A0A2K6PZU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

61622:PTPN11
gene id: 61622:PTPN11
uniprot id: A0A2K6PEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

61622:TSPAN4
gene id: 61622:TSPAN4
uniprot id: A0A2K6RK07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:TMEM170A
gene id: 61622:TMEM170A
uniprot id: A0A2K6QT65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

61622:SLC25A22
gene id: 61622:SLC25A22
uniprot id: A0A2K6RUR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:CACNA2D1
gene id: 61622:CACNA2D1
uniprot id: A0A2K6QMJ7
uniprot id: A0A2K6QMN3
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

61622:MPP4
gene id: 61622:MPP4
uniprot id: A0A2K6NKV7
names: Similarity
messages: Belongs to the MAGUK family.

61622:VAX2
gene id: 61622:VAX2
uniprot id: A0A2K6QFA5
names: Subcellular Location Annotation
messages: Nucleus

61622:KIF2A
gene id: 61622:KIF2A
uniprot id: A0A2K6N838
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:GPHB5
gene id: 61622:GPHB5
uniprot id: A0A2K6P2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

61622:TGM5
gene id: 61622:TGM5
uniprot id: A0A2K6NRB0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:MCOLN3
gene id: 61622:MCOLN3
uniprot id: A0A2K6QWW8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:STAT6
gene id: 61622:STAT6
uniprot id: A0A2K6PMP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:SLC2A1
gene id: 61622:SLC2A1
uniprot id: A0A2K6QFB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

61622:SLC5A7
gene id: 61622:SLC5A7
uniprot id: A0A2K6PUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:ESRRA
gene id: 61622:ESRRA
uniprot id: A0A2K6QT08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61622:SRP9
gene id: 61622:SRP9
uniprot id: A0A2K6NW37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

61622:NEXMIF
gene id: 61622:NEXMIF
uniprot id: A0A2K6RGS0
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104653547
gene id: 61622:LOC104653547
uniprot id: A0A2K6P4Y9
uniprot id: A0A2K6P522
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

61622:XAGE2
gene id: 61622:XAGE2
uniprot id: A0A2K6PPV8
names: Similarity
messages: Belongs to the GAGE family.

61622:APPL2
gene id: 61622:APPL2
uniprot id: A0A2K6NHH9
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

61622:ATPAF2
gene id: 61622:ATPAF2
uniprot id: A0A2K6PFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

61622:AIMP2
gene id: 61622:AIMP2
uniprot id: A0A2K6RH13
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

61622:IL17RA
gene id: 61622:IL17RA
uniprot id: A0A2K6RAU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:L3HYPDH
gene id: 61622:L3HYPDH
uniprot id: A0A2K6RQC8
names: Similarity
messages: Belongs to the proline racemase family.

61622:CTNNBL1
gene id: 61622:CTNNBL1
uniprot id: A0A2K6R8P1
names: Subcellular Location Annotation
messages: Nucleus

61622:IFI30
gene id: 61622:IFI30
uniprot id: A0A2K6PUA2
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

61622:ABR
gene id: 61622:ABR
uniprot id: A0A2K6PTE3
uniprot id: A0A2K6PTE8
uniprot id: A0A2K6PTG7
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

61622:KCNAB1
gene id: 61622:KCNAB1
uniprot id: A0A2K6N9S6
uniprot id: A0A2K6N9T8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Monomer.

61622:AK8
gene id: 61622:AK8
uniprot id: A0A2K6NBZ3
names: Similarity
messages: Belongs to the adenylate kinase family.

61622:TLCD3B
gene id: 61622:TLCD3B
uniprot id: A0A2K6NM14
names: Subcellular Location Annotation
messages: Membrane

61622:LDHD
gene id: 61622:LDHD
uniprot id: A0A2K6R178
uniprot id: A0A2K6R182
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

61622:CNOT2
gene id: 61622:CNOT2
uniprot id: A0A2K6RBW5
uniprot id: A0A2K6RBY3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

61622:FAM210A
gene id: 61622:FAM210A
uniprot id: A0A2K6QGL1
names: Similarity
messages: Belongs to the FAM210 family.

61622:FAM124A
gene id: 61622:FAM124A
uniprot id: A0A2K6NZ02
names: Similarity
messages: Belongs to the FAM124 family.

61622:DTX3
gene id: 61622:DTX3
uniprot id: A0A2K6RBS7
uniprot id: A0A2K6RBT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61622:DPM1
gene id: 61622:DPM1
uniprot id: A0A2K6Q8Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

61622:HSF4
gene id: 61622:HSF4
uniprot id: A0A2K6RB16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:CENPJ
gene id: 61622:CENPJ
uniprot id: A0A2K6R1C6
names: Similarity
messages: Belongs to the TCP10 family.

61622:TYSND1
gene id: 61622:TYSND1
uniprot id: A0A2K6N999
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

61622:ING3
gene id: 61622:ING3
uniprot id: A0A2K6P2C8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:TBX4
gene id: 61622:TBX4
uniprot id: A0A2K6P1V5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:LOC104672095
gene id: 61622:LOC104672095
uniprot id: A0A2K6PIX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:C8H1orf43
gene id: 61622:C8H1orf43
uniprot id: A0A2K6NQJ4
uniprot id: A0A2K6NQJ8
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

61622:GABRR2
gene id: 61622:GABRR2
uniprot id: A0A2K6Q6Z5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:AHCY
gene id: 61622:AHCY
uniprot id: A0A2K6Q2C3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61622:CBR3
gene id: 61622:CBR3
uniprot id: A0A2K6QE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

61622:ST6GAL2
gene id: 61622:ST6GAL2
uniprot id: A0A2K6QUY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

61622:INPP1
gene id: 61622:INPP1
uniprot id: A0A2K6NXV9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:LSM4
gene id: 61622:LSM4
uniprot id: A0A2K6RX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

61622:MSMB
gene id: 61622:MSMB
uniprot id: A0A2K6QUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

61622:TRIM25
gene id: 61622:TRIM25
uniprot id: A0A2K6QC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

61622:LOC104674747
gene id: 61622:LOC104674747
uniprot id: A0A2K6PZQ8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:TBX19
gene id: 61622:TBX19
uniprot id: A0A2K6N8M3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:TEX261
gene id: 61622:TEX261
uniprot id: A0A2K6P471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

61622:CFHR5
gene id: 61622:CFHR5
uniprot id: A0A2K6QEW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:KLHL15
gene id: 61622:KLHL15
uniprot id: A0A2K6P4D5
names: Subcellular Location Annotation
messages: Nucleus

61622:HKDC1
gene id: 61622:HKDC1
uniprot id: A0A2K6Q4H2
names: Similarity
messages: Belongs to the hexokinase family.

61622:BHMT2
gene id: 61622:BHMT2
uniprot id: A0A2K6QQ30
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

61622:LIN54
gene id: 61622:LIN54
uniprot id: A0A2K6RC27
uniprot id: A0A2K6RC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

61622:CD40
gene id: 61622:CD40
uniprot id: A0A2K6Q9B7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CNIH4
gene id: 61622:CNIH4
uniprot id: A0A2K6RWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

61622:MTERF3
gene id: 61622:MTERF3
uniprot id: A0A2K6NVG7
names: Similarity
messages: Belongs to the mTERF family.

61622:SFTPC
gene id: 61622:SFTPC
uniprot id: A0A2K6QM30
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

61622:ERBIN
gene id: 61622:ERBIN
uniprot id: A0A2K6R0Y6
uniprot id: A0A2K6R0Z2
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

61622:CCNJ
gene id: 61622:CCNJ
uniprot id: A0A2K6N7T8
names: Similarity
messages: Belongs to the cyclin family.

61622:HJV
gene id: 61622:HJV
uniprot id: A0A2K6QT76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61622:SERF1A
gene id: 61622:SERF1A
uniprot id: A0A2K6QIH5
uniprot id: A0A2K6QIH9
names: Similarity
messages: Belongs to the SERF family.

61622:C7
gene id: 61622:C7
uniprot id: A0A2K6QZQ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:HSD17B12
gene id: 61622:HSD17B12
uniprot id: A0A2K6R6D3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:POLR1D
gene id: 61622:POLR1D
uniprot id: A0A2K6R9B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

61622:LOC104676553
gene id: 61622:LOC104676553
uniprot id: A0A2K6NAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61622:RNASEH1
gene id: 61622:RNASEH1
uniprot id: A0A2K6R6F7
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

61622:GNA11
gene id: 61622:GNA11
uniprot id: A0A2K6PJ32
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61622:ARG1
gene id: 61622:ARG1
uniprot id: A0A2K6Q0I6
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

61622:LOC104677573
gene id: 61622:LOC104677573
uniprot id: A0A2K6NGZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61622:ST6GALNAC2
gene id: 61622:ST6GALNAC2
uniprot id: A0A2K6Q7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:DPF2
gene id: 61622:DPF2
uniprot id: A0A2K6Q9W0
names: Similarity
messages: Belongs to the requiem/DPF family.

61622:MIS18A
gene id: 61622:MIS18A
uniprot id: A0A2K6QHN0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

61622:SERINC2
gene id: 61622:SERINC2
uniprot id: A0A2K6RW85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61622:GADL1
gene id: 61622:GADL1
uniprot id: A0A2K6RHV5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61622:CPLX2
gene id: 61622:CPLX2
uniprot id: A0A2K6NTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61622:EP300
gene id: 61622:EP300
uniprot id: A0A2K6QGX0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PYCR2
gene id: 61622:PYCR2
uniprot id: A0A2K6RNK9
uniprot id: A0A2K6RNL1
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61622:PUF60
gene id: 61622:PUF60
uniprot id: A0A2K6P054
uniprot id: A0A2K6P055
uniprot id: A0A2K6P057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

61622:TNFAIP3
gene id: 61622:TNFAIP3
uniprot id: A0A2K6R5C6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:ITK
gene id: 61622:ITK
uniprot id: A0A2K6QBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

61622:GALNT18
gene id: 61622:GALNT18
uniprot id: A0A2K6R026
uniprot id: A0A2K6R064
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:NCK1
gene id: 61622:NCK1
uniprot id: A0A2K6RPL8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

61622:CLTRN
gene id: 61622:CLTRN
uniprot id: A0A2K6P148
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SPATS2L
gene id: 61622:SPATS2L
uniprot id: A0A2K6R376
uniprot id: A0A2K6R3A2
names: Similarity
messages: Belongs to the SPATS2 family.

61622:RPL27A
gene id: 61622:RPL27A
uniprot id: A0A2K6Q2X0
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

61622:GTF2H2
gene id: 61622:GTF2H2
uniprot id: A0A2K6QPP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

61622:UTP3
gene id: 61622:UTP3
uniprot id: A0A2K6NBL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

61622:EXOC5
gene id: 61622:EXOC5
uniprot id: A0A2K6QEE9
names: Similarity
messages: Belongs to the SEC10 family.

61622:PGD
gene id: 61622:PGD
uniprot id: A0A2K6NJH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

61622:SLC25A27
gene id: 61622:SLC25A27
uniprot id: A0A2K6QXN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:RAD21
gene id: 61622:RAD21
uniprot id: A0A2K6NN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

61622:MPC2
gene id: 61622:MPC2
uniprot id: A0A2K6P2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ISCU
gene id: 61622:ISCU
uniprot id: A0A2K6QUI6
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

61622:PDXK
gene id: 61622:PDXK
uniprot id: A0A2K6RNF7
names: Similarity
messages: Belongs to the pyridoxine kinase family.

61622:HCN1
gene id: 61622:HCN1
uniprot id: A0A2K6PWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

61622:BRMS1
gene id: 61622:BRMS1
uniprot id: A0A2K6QBP5
names: Subcellular Location Annotation
messages: Nucleus

61622:ACSL6
gene id: 61622:ACSL6
uniprot id: A0A2K6NNM2
uniprot id: A0A2K6NNM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

61622:LOC104675289
gene id: 61622:LOC104675289
uniprot id: A0A2K6N8T0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:UBE2G1
gene id: 61622:UBE2G1
uniprot id: A0A2K6N7W8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:TP53BP1
gene id: 61622:TP53BP1
uniprot id: A0A2K6NCI4
names: Subcellular Location Annotation
messages: Nucleus

61622:GALP
gene id: 61622:GALP
uniprot id: A0A2K6PV20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
messages: Secreted

61622:FAR1
gene id: 61622:FAR1
uniprot id: A0A2K6PLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

61622:LOC104678157
gene id: 61622:LOC104678157
uniprot id: A0A2K6QJQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:RNF182
gene id: 61622:RNF182
uniprot id: A0A2K6NP84
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

61622:KRT23
gene id: 61622:KRT23
uniprot id: A0A2K6PMP5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:ABHD2
gene id: 61622:ABHD2
uniprot id: A0A2K6QIG8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

61622:CSF2
gene id: 61622:CSF2
uniprot id: A0A2K6R8E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

61622:OC90
gene id: 61622:OC90
uniprot id: A0A2K6RIA5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:INTS10
gene id: 61622:INTS10
uniprot id: A0A2K6PFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

61622:DPP3
gene id: 61622:DPP3
uniprot id: A0A2K6RLB2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

61622:FZD6
gene id: 61622:FZD6
uniprot id: A0A2K6PSF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GML
gene id: 61622:GML
uniprot id: A0A2K6RDD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CLPX
gene id: 61622:CLPX
uniprot id: A0A2K6PN36
names: Similarity
messages: Belongs to the ClpX chaperone family.

61622:PTPN1
gene id: 61622:PTPN1
uniprot id: A0A2K6R9L8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

61622:LOC104670086
gene id: 61622:LOC104670086
uniprot id: A0A2K6QFN4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61622:LCLAT1
gene id: 61622:LCLAT1
uniprot id: A0A2K6QJ63
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

61622:KCNH7
gene id: 61622:KCNH7
uniprot id: A0A2K6RAS7
uniprot id: A0A2K6RAX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

61622:TMED4
gene id: 61622:TMED4
uniprot id: A0A2K6R3R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PHTF1
gene id: 61622:PHTF1
uniprot id: A0A2K6QT37
names: Subcellular Location Annotation
messages: Membrane

61622:MTMR4
gene id: 61622:MTMR4
uniprot id: A0A2K6NL96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

61622:PPIA
gene id: 61622:PPIA
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:ATP4A
gene id: 61622:ATP4A
uniprot id: A0A2K6RIT1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

61622:ZSCAN2
gene id: 61622:ZSCAN2
uniprot id: A0A2K6QQT2
names: Subcellular Location Annotation
messages: Nucleus

61622:MSH4
gene id: 61622:MSH4
uniprot id: A0A2K6QXX7
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

61622:PDIA2
gene id: 61622:PDIA2
uniprot id: A0A2K6N957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

61622:LCA5
gene id: 61622:LCA5
uniprot id: A0A2K6PLP2
names: Similarity
messages: Belongs to the LCA5 family.

61622:NKX2-5
gene id: 61622:NKX2-5
uniprot id: A0A2K6RGA7
names: Subcellular Location Annotation
messages: Nucleus

61622:CPD
gene id: 61622:CPD
uniprot id: A0A2K6RF42
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:SMAD7
gene id: 61622:SMAD7
uniprot id: A0A2K6RHH7
names: Subcellular Location Annotation
messages: Nucleus

61622:CKAP5
gene id: 61622:CKAP5
uniprot id: A0A2K6QUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

61622:A1CF
gene id: 61622:A1CF
uniprot id: A0A2K6R4C7
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PISD
gene id: 61622:PISD
uniprot id: A0A2K6PXH4
uniprot id: A0A2K6PXI2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

61622:SERPINA11
gene id: 61622:SERPINA11
uniprot id: A0A2K6P518
names: Similarity
messages: Belongs to the serpin family.

61622:TMEM106A
gene id: 61622:TMEM106A
uniprot id: A0A2K6Q7Q1
names: Similarity
messages: Belongs to the TMEM106 family.

61622:AMPD1
gene id: 61622:AMPD1
uniprot id: A0A2K6QHW2
uniprot id: A0A2K6QHX4
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61622:IL2
gene id: 61622:IL2
uniprot id: A0A2K6NXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

61622:UBE2C
gene id: 61622:UBE2C
uniprot id: A0A2K6NMA4
uniprot id: A0A2K6Q9Y1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:AMD1
gene id: 61622:AMD1
uniprot id: A0A2K6QM05
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

61622:SLC35D1
gene id: 61622:SLC35D1
uniprot id: A0A2K6QDI5
names: Subcellular Location Annotation
messages: Membrane

61622:TRIM68
gene id: 61622:TRIM68
uniprot id: A0A2K6RA48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:SERPINF1
gene id: 61622:SERPINF1
uniprot id: A0A2K6NG92
names: Similarity
messages: Belongs to the serpin family.

61622:CPSF3
gene id: 61622:CPSF3
uniprot id: A0A2K6PSV5
names: Subcellular Location Annotation
messages: Nucleus

61622:MUSK
gene id: 61622:MUSK
uniprot id: A0A2K6NEU8
uniprot id: A0A2K6NEV2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ST6GAL1
gene id: 61622:ST6GAL1
uniprot id: A0A2K6NEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:P3H1
gene id: 61622:P3H1
uniprot id: A0A2K6QJP7
names: Similarity
messages: Belongs to the leprecan family.

61622:PTPA
gene id: 61622:PTPA
uniprot id: A0A2K6PW82
uniprot id: A0A2K6PW86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:PRLR
gene id: 61622:PRLR
uniprot id: A0A2K6NVZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

61622:LOC104655171
gene id: 61622:LOC104655171
uniprot id: A0A2K6R6A4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

61622:ACTR3B
gene id: 61622:ACTR3B
uniprot id: A0A2K6RSM7
names: Similarity
messages: Belongs to the actin family.

61622:GKAP1
gene id: 61622:GKAP1
uniprot id: A0A2K6ND96
uniprot id: A0A2K6NDB3
names: Similarity
messages: Belongs to the GKAP1 family.

61622:EYA4
gene id: 61622:EYA4
uniprot id: A0A2K6PZR6
uniprot id: A0A2K6PZS3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

61622:MTMR9
gene id: 61622:MTMR9
uniprot id: A0A2K6Q498
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61622:TLR8
gene id: 61622:TLR8
uniprot id: A0A2K6P591
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61622:ABCC2
gene id: 61622:ABCC2
uniprot id: A0A2K6R7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:LOC104673179
gene id: 61622:LOC104673179
uniprot id: A0A2K6RH19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61622:GPR107
gene id: 61622:GPR107
uniprot id: A0A2K6RHW5
uniprot id: A0A2K6RHW6
names: Subcellular Location Annotation
messages: Membrane

61622:THBS2
gene id: 61622:THBS2
uniprot id: A0A2K6QLW7
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ABCG4
gene id: 61622:ABCG4
uniprot id: A0A2K6PN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61622:ACD
gene id: 61622:ACD
uniprot id: A0A2K6NBI1
uniprot id: A0A2K6NBI7
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

61622:ELL3
gene id: 61622:ELL3
uniprot id: A0A2K6NLQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

61622:GAB1
gene id: 61622:GAB1
uniprot id: A0A2K6P4L2
uniprot id: A0A2K6P4N0
names: Similarity
messages: Belongs to the GAB family.

61622:PSME1
gene id: 61622:PSME1
uniprot id: A0A2K6RND7
names: Similarity
messages: Belongs to the PA28 family.

61622:IMPG2
gene id: 61622:IMPG2
uniprot id: A0A2K6PLJ4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

61622:CHAF1B
gene id: 61622:CHAF1B
uniprot id: A0A2K6NSZ8
names: Subcellular Location Annotation
messages: Nucleus

61622:MRPL41
gene id: 61622:MRPL41
uniprot id: A0A2K6NE76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

61622:ANKZF1
gene id: 61622:ANKZF1
uniprot id: A0A2K6Q2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

61622:SMC4
gene id: 61622:SMC4
uniprot id: A0A2K6PWS1
uniprot id: A0A2K6PWS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

61622:ACP1
gene id: 61622:ACP1
uniprot id: A0A2K6QZV6
uniprot id: A0A2K6QZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

61622:APLN
gene id: 61622:APLN
uniprot id: A0A2K6RR72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

61622:TSEN54
gene id: 61622:TSEN54
uniprot id: A0A2K6P957
names: Similarity
messages: Belongs to the SEN54 family.

61622:PTCD3
gene id: 61622:PTCD3
uniprot id: A0A2K6R969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

61622:PRRX1
gene id: 61622:PRRX1
uniprot id: A0A2K6PX79
uniprot id: A0A2K6PX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61622:RPL23A
gene id: 61622:RPL23A
uniprot id: A0A2K6PBJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

61622:SLC30A6
gene id: 61622:SLC30A6
uniprot id: A0A2K6PNG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:NUF2
gene id: 61622:NUF2
uniprot id: A0A2K6P491
names: Similarity
messages: Belongs to the NUF2 family.

61622:PDK4
gene id: 61622:PDK4
uniprot id: A0A2K6Q4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:DCSTAMP
gene id: 61622:DCSTAMP
uniprot id: A0A2K6PDD3
uniprot id: A0A2K6PDI2
names: Subcellular Location Annotation
messages: Membrane

61622:ALDH1L1
gene id: 61622:ALDH1L1
uniprot id: A0A2K6RTE0
uniprot id: A0A2K6RTF7
uniprot id: A0A2K6RTG9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

61622:ISOC2
gene id: 61622:ISOC2
uniprot id: A0A2K6R739
names: Similarity
messages: Belongs to the isochorismatase family.

61622:FAM241B
gene id: 61622:FAM241B
uniprot id: A0A2K6Q1U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

61622:SULT2B1
gene id: 61622:SULT2B1
uniprot id: A0A2K6R469
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:SLC25A46
gene id: 61622:SLC25A46
uniprot id: A0A2K6NV94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:WNT5A
gene id: 61622:WNT5A
uniprot id: A0A2K6PGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:ZFPM2
gene id: 61622:ZFPM2
uniprot id: A0A2K6PI43
names: Subcellular Location Annotation
messages: Nucleus

61622:KCNA10
gene id: 61622:KCNA10
uniprot id: A0A2K6NHJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PPIB
gene id: 61622:PPIB
uniprot id: A0A2K6Q3I8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:SHFL
gene id: 61622:SHFL
uniprot id: A0A2K6Q8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Nucleus

61622:CNR2
gene id: 61622:CNR2
uniprot id: A0A2K6NE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ATP6V1B2
gene id: 61622:ATP6V1B2
uniprot id: A0A2K6RJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

61622:FOLR1
gene id: 61622:FOLR1
uniprot id: A0A2K6R864
names: Similarity
messages: Belongs to the folate receptor family.

61622:ZZZ3
gene id: 61622:ZZZ3
uniprot id: A0A2K6QHS2
names: Subcellular Location Annotation
messages: Nucleus

61622:FOXP4
gene id: 61622:FOXP4
uniprot id: A0A2K6RGU7
names: Subcellular Location Annotation
messages: Nucleus

61622:BARX2
gene id: 61622:BARX2
uniprot id: A0A2K6N749
names: Subcellular Location Annotation
messages: Nucleus

61622:CRISP3
gene id: 61622:CRISP3
uniprot id: A0A2K6NSF8
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LMBR1L
gene id: 61622:LMBR1L
uniprot id: A0A2K6RLK7
names: Similarity
messages: Belongs to the LIMR family.

61622:TOR1B
gene id: 61622:TOR1B
uniprot id: A0A2K6NWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

61622:CD38
gene id: 61622:CD38
uniprot id: A0A2K6P8H1
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

61622:ALDH1A1
gene id: 61622:ALDH1A1
uniprot id: A0A2K6Q6D7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:VIPR1
gene id: 61622:VIPR1
uniprot id: A0A2K6NW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

61622:ARHGEF11
gene id: 61622:ARHGEF11
uniprot id: A0A2K6NT68
uniprot id: A0A2K6NT71
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

61622:HSD17B4
gene id: 61622:HSD17B4
uniprot id: A0A2K6NTF4
names: Subcellular Location Annotation
messages: Peroxisome

61622:ARMC8
gene id: 61622:ARMC8
uniprot id: A0A2K6RMW0
uniprot id: A0A2K6RMW3
uniprot id: A0A2K6RMX0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:OTOP3
gene id: 61622:OTOP3
uniprot id: A0A2K6PQX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61622:TIMM22
gene id: 61622:TIMM22
uniprot id: A0A2K6QAE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

61622:RAMP2
gene id: 61622:RAMP2
uniprot id: A0A2K6RM81
names: Similarity
messages: Belongs to the RAMP family.

61622:DACT2
gene id: 61622:DACT2
uniprot id: A0A2K6PH15
names: Similarity
messages: Belongs to the dapper family.

61622:QSOX1
gene id: 61622:QSOX1
uniprot id: A0A2K6RE49
uniprot id: A0A2K6RE53
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

61622:ITIH3
gene id: 61622:ITIH3
uniprot id: A0A2K6RM64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:FOXS1
gene id: 61622:FOXS1
uniprot id: A0A2K6NAK7
names: Subcellular Location Annotation
messages: Nucleus

61622:KCNJ13
gene id: 61622:KCNJ13
uniprot id: A0A2K6R6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:PLA2G1B
gene id: 61622:PLA2G1B
uniprot id: A0A2K6RSU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:SLC35F2
gene id: 61622:SLC35F2
uniprot id: A0A2K6R7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

61622:GCLM
gene id: 61622:GCLM
uniprot id: A0A2K6REB2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

61622:TRAP1
gene id: 61622:TRAP1
uniprot id: A0A2K6Q8U1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

61622:ODF1
gene id: 61622:ODF1
uniprot id: A0A2K6R5B9
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

61622:HIGD2A
gene id: 61622:HIGD2A
uniprot id: A0A2K6QSP3
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

61622:MMP23B
gene id: 61622:MMP23B
uniprot id: A0A2K6P4E6
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CD68
gene id: 61622:CD68
uniprot id: A0A2K6Q7N1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

61622:HOXC4
gene id: 61622:HOXC4
uniprot id: A0A2K6PH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:PPM1K
gene id: 61622:PPM1K
uniprot id: A0A2K6PMZ3
names: Similarity
messages: Belongs to the PP2C family.

61622:PGLYRP3
gene id: 61622:PGLYRP3
uniprot id: A0A2K6NZW7
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

61622:ZSCAN21
gene id: 61622:ZSCAN21
uniprot id: A0A2K6QAX0
names: Subcellular Location Annotation
messages: Nucleus

61622:NDUFS6
gene id: 61622:NDUFS6
uniprot id: A0A2K6PRT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

61622:RPLP1
gene id: 61622:RPLP1
uniprot id: A0A2K6NU46
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

61622:ICOS
gene id: 61622:ICOS
uniprot id: A0A2K6QJK8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

61622:RAB3D
gene id: 61622:RAB3D
uniprot id: A0A2K6PM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

61622:LOC104664783
gene id: 61622:LOC104664783
uniprot id: A0A2K6PBJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

61622:HAO1
gene id: 61622:HAO1
uniprot id: A0A2K6QJC8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

61622:GJA5
gene id: 61622:GJA5
uniprot id: A0A2K6NRE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:GABRA4
gene id: 61622:GABRA4
uniprot id: A0A2K6RII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:SSR3
gene id: 61622:SSR3
uniprot id: A0A2K6QEC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

61622:EIF4E1B
gene id: 61622:EIF4E1B
uniprot id: A0A2K6R8F4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61622:KCNA5
gene id: 61622:KCNA5
uniprot id: A0A2K6NQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

61622:AGA
gene id: 61622:AGA
uniprot id: A0A2K6NTT0
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

61622:IDH3G
gene id: 61622:IDH3G
uniprot id: A0A2K6RN47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:LOC104672897
gene id: 61622:LOC104672897
uniprot id: A0A2K6NG46
names: Subcellular Location Annotation
messages: Nucleus

61622:CLEC18C
gene id: 61622:CLEC18C
uniprot id: A0A2K6RRM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104678039
gene id: 61622:LOC104678039
uniprot id: A0A2K6PND1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61622:ZMPSTE24
gene id: 61622:ZMPSTE24
uniprot id: A0A2K6NZZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

61622:MALSU1
gene id: 61622:MALSU1
uniprot id: A0A2K6RPZ1
names: Similarity
messages: Belongs to the Iojap/RsfS family.

61622:F2RL2
gene id: 61622:F2RL2
uniprot id: A0A2K6QJ56
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:COQ5
gene id: 61622:COQ5
uniprot id: A0A2K6QJJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

61622:LOC104668837
gene id: 61622:LOC104668837
uniprot id: A0A2K6PYM3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61622:MGRN1
gene id: 61622:MGRN1
uniprot id: A0A2K6RD39
uniprot id: A0A2K6RD41
uniprot id: A0A2K6RD52
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

61622:TUFM
gene id: 61622:TUFM
uniprot id: A0A2K6QBS2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:PTCH2
gene id: 61622:PTCH2
uniprot id: A0A2K6NAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

61622:ACTG2
gene id: 61622:ACTG2
uniprot id: A0A2K6RD88
names: Similarity
messages: Belongs to the actin family.

61622:PLCG2
gene id: 61622:PLCG2
uniprot id: A0A2K6RT65
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

61622:LAPTM5
gene id: 61622:LAPTM5
uniprot id: A0A2K6N772
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61622:SOST
gene id: 61622:SOST
uniprot id: A0A2K6RNL8
names: Similarity
messages: Belongs to the sclerostin family.

61622:ETV5
gene id: 61622:ETV5
uniprot id: A0A2K6NIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:GABARAP
gene id: 61622:GABARAP
uniprot id: A0A2K6N840
names: Similarity
messages: Belongs to the ATG8 family.

61622:TSC22D4
gene id: 61622:TSC22D4
uniprot id: A0A2K6RE81
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61622:DOCK5
gene id: 61622:DOCK5
uniprot id: A0A2K6NUG2
names: Similarity
messages: Belongs to the DOCK family.

61622:CAMK1
gene id: 61622:CAMK1
uniprot id: A0A2K6RAA2
uniprot id: A0A2K6RAD6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GJB2
gene id: 61622:GJB2
uniprot id: A0A2K6NI40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:CFH
gene id: 61622:CFH
uniprot id: A0A2K6PRN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NUP133
gene id: 61622:NUP133
uniprot id: A0A2K6NAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

61622:SLC17A9
gene id: 61622:SLC17A9
uniprot id: A0A2K6R639
names: Subcellular Location Annotation
messages: Membrane

61622:CASS4
gene id: 61622:CASS4
uniprot id: A0A2K6R7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:PSMA2
gene id: 61622:PSMA2
uniprot id: A0A2K6PDA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:CRHR1
gene id: 61622:CRHR1
uniprot id: A0A2K6PDG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

61622:LOC104676348
gene id: 61622:LOC104676348
uniprot id: A0A2K6RKG9
names: Similarity
messages: Belongs to the S-100 family.

61622:CENPK
gene id: 61622:CENPK
uniprot id: A0A2K6QD54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

61622:TLX2
gene id: 61622:TLX2
uniprot id: A0A2K6RUE3
names: Subcellular Location Annotation
messages: Nucleus

61622:CCN4
gene id: 61622:CCN4
uniprot id: A0A2K6RLM1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:DUS3L
gene id: 61622:DUS3L
uniprot id: A0A2K6QCP9
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

61622:RBM8A
gene id: 61622:RBM8A
uniprot id: A0A2K6QXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

61622:PPM1N
gene id: 61622:PPM1N
uniprot id: A0A2K6NZC5
names: Similarity
messages: Belongs to the PP2C family.

61622:SLC16A14
gene id: 61622:SLC16A14
uniprot id: A0A2K6PDY5
names: Subcellular Location Annotation
messages: Membrane

61622:AP1G2
gene id: 61622:AP1G2
uniprot id: A0A2K6Q082
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:PRPF4
gene id: 61622:PRPF4
uniprot id: A0A2K6QWY2
names: Subcellular Location Annotation
messages: Nucleus speckle

61622:ELOVL4
gene id: 61622:ELOVL4
uniprot id: A0A2K6NWM0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61622:VPS33A
gene id: 61622:VPS33A
uniprot id: A0A2K6NP05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

61622:RAP2A
gene id: 61622:RAP2A
uniprot id: A0A2K6R8D8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

61622:TSHZ3
gene id: 61622:TSHZ3
uniprot id: A0A2K6P4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

61622:LOC104681098
gene id: 61622:LOC104681098
uniprot id: A0A2K6NPJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ASRGL1
gene id: 61622:ASRGL1
uniprot id: A0A2K6PDV4
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

61622:FRZB
gene id: 61622:FRZB
uniprot id: A0A2K6RVE9
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

61622:CAVIN3
gene id: 61622:CAVIN3
uniprot id: A0A2K6NFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

61622:CTSL
gene id: 61622:CTSL
uniprot id: A0A2K6QK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:LOC104671023
gene id: 61622:LOC104671023
uniprot id: A0A2K6NU81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MRPL18
gene id: 61622:MRPL18
uniprot id: A0A2K6P5X0
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

61622:DYNC1LI1
gene id: 61622:DYNC1LI1
uniprot id: A0A2K6P7H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

61622:ST6GALNAC4
gene id: 61622:ST6GALNAC4
uniprot id: A0A2K6Q6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:SYNGR4
gene id: 61622:SYNGR4
uniprot id: A0A2K6NDX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

61622:STAC3
gene id: 61622:STAC3
uniprot id: A0A2K6NSY4
names: Subcellular Location Annotation
messages: sarcolemma

61622:LZTFL1
gene id: 61622:LZTFL1
uniprot id: A0A2K6RGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

61622:PDC
gene id: 61622:PDC
uniprot id: A0A2K6PHP6
names: Similarity
messages: Belongs to the phosducin family.

61622:LOC104679773
gene id: 61622:LOC104679773
uniprot id: A0A2K6QGP8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:CCKAR
gene id: 61622:CCKAR
uniprot id: A0A2K6P4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

61622:LOC104663295
gene id: 61622:LOC104663295
uniprot id: A0A2K6PP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

61622:NEDD9
gene id: 61622:NEDD9
uniprot id: A0A2K6QID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:KCTD10
gene id: 61622:KCTD10
uniprot id: A0A2K6Q4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

61622:CACNG5
gene id: 61622:CACNG5
uniprot id: A0A2K6P8S9
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

61622:LOC104680824
gene id: 61622:LOC104680824
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:LOC104672859
gene id: 61622:LOC104672859
uniprot id: A0A2K6NQZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:LOC104673884
gene id: 61622:LOC104673884
uniprot id: A0A2K6QVH2
names: Similarity
messages: Belongs to the MHC class II family.

61622:CACNA1E
gene id: 61622:CACNA1E
uniprot id: A0A2K6P825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.

61622:LOC104663917
gene id: 61622:LOC104663917
uniprot id: A0A2K6QER2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

61622:DEFB124
gene id: 61622:DEFB124
uniprot id: A0A2K6P6X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:KLC1
gene id: 61622:KLC1
uniprot id: A0A2K6PZH1
uniprot id: A0A2K6PZI6
uniprot id: A0A2K6PZI7
uniprot id: A0A2K6PZJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:SLC16A9
gene id: 61622:SLC16A9
uniprot id: A0A2K6PPZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

61622:TRAPPC6A
gene id: 61622:TRAPPC6A
uniprot id: A0A2K6PG46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

61622:LOC104670892
gene id: 61622:LOC104670892
uniprot id: A0A2K6RPU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104662339
gene id: 61622:LOC104662339
uniprot id: A0A2K6Q8D1
names: Similarity
messages: Belongs to the globin family.

61622:TMC2
gene id: 61622:TMC2
uniprot id: A0A2K6NG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:CKAP2L
gene id: 61622:CKAP2L
uniprot id: A0A2K6QWC7
names: Similarity
messages: Belongs to the CKAP2 family.

61622:YIF1A
gene id: 61622:YIF1A
uniprot id: A0A2K6R650
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

61622:USP20
gene id: 61622:USP20
uniprot id: A0A2K6QCN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

61622:EXOC8
gene id: 61622:EXOC8
uniprot id: A0A2K6N828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

61622:LOC104673241
gene id: 61622:LOC104673241
uniprot id: A0A2K6P4U2
uniprot id: A0A2K6P4U7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

61622:ZSCAN18
gene id: 61622:ZSCAN18
uniprot id: A0A2K6P121
names: Subcellular Location Annotation
messages: Nucleus

61622:CCDC181
gene id: 61622:CCDC181
uniprot id: A0A2K6PUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

61622:RPS16
gene id: 61622:RPS16
uniprot id: A0A2K6NYB8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

61622:MMGT1
gene id: 61622:MMGT1
uniprot id: A0A2K6RIB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

61622:SLC2A11
gene id: 61622:SLC2A11
uniprot id: A0A2K6NT49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

61622:KRT32
gene id: 61622:KRT32
uniprot id: A0A2K6Q188
names: Similarity
messages: Belongs to the intermediate filament family.

61622:LOC104665626
gene id: 61622:LOC104665626
uniprot id: A0A2K6NBW4
names: Similarity
messages: Belongs to the ATG8 family.

61622:THTPA
gene id: 61622:THTPA
uniprot id: A0A2K6PHC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

61622:FUBP1
gene id: 61622:FUBP1
uniprot id: A0A2K6RIH0
names: Subcellular Location Annotation
messages: Nucleus

61622:NXPH4
gene id: 61622:NXPH4
uniprot id: A0A2K6NSJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61622:CNPY2
gene id: 61622:CNPY2
uniprot id: A0A2K6RT47
names: Similarity
messages: Belongs to the canopy family.

61622:FICD
gene id: 61622:FICD
uniprot id: A0A2K6P971
names: Similarity
messages: Belongs to the fic family.

61622:F13B
gene id: 61622:F13B
uniprot id: A0A2K6PSF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NDUFS4
gene id: 61622:NDUFS4
uniprot id: A0A2K6NDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

61622:EIF4G1
gene id: 61622:EIF4G1
uniprot id: A0A2K6NAW9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

61622:STAMBPL1
gene id: 61622:STAMBPL1
uniprot id: A0A2K6PJX2
names: Similarity
messages: Belongs to the peptidase M67C family.

61622:ATP6AP1L
gene id: 61622:ATP6AP1L
uniprot id: A0A2K6QZ90
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

61622:NEFL
gene id: 61622:NEFL
uniprot id: A0A2K6QD38
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SSTR2
gene id: 61622:SSTR2
uniprot id: A0A2K6N8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

61622:ABCA13
gene id: 61622:ABCA13
uniprot id: A0A2K6RAY4
names: Subcellular Location Annotation
messages: Membrane

61622:AGTPBP1
gene id: 61622:AGTPBP1
uniprot id: A0A2K6QAN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

61622:RBFOX2
gene id: 61622:RBFOX2
uniprot id: A0A2K6Q4R1
uniprot id: A0A2K6Q4T5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

61622:SLC25A13
gene id: 61622:SLC25A13
uniprot id: A0A2K6Q4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ABCB1
gene id: 61622:ABCB1
uniprot id: A0A2K6Q9U5
names: Subcellular Location Annotation
messages: Membrane

61622:TOP2A
gene id: 61622:TOP2A
uniprot id: A0A2K6PZD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

61622:GMPPB
gene id: 61622:GMPPB
uniprot id: A0A2K6NFH2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

61622:SERP1
gene id: 61622:SERP1
uniprot id: A0A2K6PBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

61622:UBP1
gene id: 61622:UBP1
uniprot id: A0A2K6PBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:BMPR1B
gene id: 61622:BMPR1B
uniprot id: A0A2K6PW17
uniprot id: A0A2K6PW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:EBP
gene id: 61622:EBP
uniprot id: A0A2K6RRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:IL1R1
gene id: 61622:IL1R1
uniprot id: A0A2K6P4G6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:CDH7
gene id: 61622:CDH7
uniprot id: A0A2K6RV23
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:TUBA1C
gene id: 61622:TUBA1C
uniprot id: A0A2K6R6K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:DOCK4
gene id: 61622:DOCK4
uniprot id: A0A2K6QLI7
names: Similarity
messages: Belongs to the DOCK family.

61622:TEKT5
gene id: 61622:TEKT5
uniprot id: A0A2K6QRP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61622:IGF2BP1
gene id: 61622:IGF2BP1
uniprot id: A0A2K6QSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

61622:IL10
gene id: 61622:IL10
uniprot id: A0A2K6RPG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61622:TBCD
gene id: 61622:TBCD
uniprot id: A0A2K6PMP7
names: Similarity
messages: Belongs to the TBCD family.

61622:ELOVL5
gene id: 61622:ELOVL5
uniprot id: A0A2K6QNQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

61622:GPR171
gene id: 61622:GPR171
uniprot id: A0A2K6NIB3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PRPSAP1
gene id: 61622:PRPSAP1
uniprot id: A0A2K6PKX2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

61622:HADHA
gene id: 61622:HADHA
uniprot id: A0A2K6PM13
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

61622:ISM2
gene id: 61622:ISM2
uniprot id: A0A2K6Q467
names: Similarity
messages: Belongs to the isthmin family.

61622:EXTL1
gene id: 61622:EXTL1
uniprot id: A0A2K6R3Z1
uniprot id: A0A2K6R3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CDC37
gene id: 61622:CDC37
uniprot id: A0A2K6P6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

61622:EPHB1
gene id: 61622:EPHB1
uniprot id: A0A2K6NCC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

61622:SPX
gene id: 61622:SPX
uniprot id: A0A2K6NIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

61622:LOC104655970
gene id: 61622:LOC104655970
uniprot id: A0A2K6QKS4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

61622:ERAP2
gene id: 61622:ERAP2
uniprot id: A0A2K6QF64
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:LOC104657701
gene id: 61622:LOC104657701
uniprot id: A0A2K6QDL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:OSBPL8
gene id: 61622:OSBPL8
uniprot id: A0A2K6RBD6
uniprot id: A0A2K6RBF4
names: Similarity
messages: Belongs to the OSBP family.

61622:TIMM13
gene id: 61622:TIMM13
uniprot id: A0A2K6RH19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61622:TBC1D24
gene id: 61622:TBC1D24
uniprot id: A0A2K6QYR3
uniprot id: A0A2K6QYS8
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

61622:PPIL2
gene id: 61622:PPIL2
uniprot id: A0A2K6QNH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

61622:XPO5
gene id: 61622:XPO5
uniprot id: A0A2K6P866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

61622:ALDH18A1
gene id: 61622:ALDH18A1
uniprot id: A0A2K6QH93
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

61622:CHEK1
gene id: 61622:CHEK1
uniprot id: A0A2K6QG95
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

61622:LOC104679443
gene id: 61622:LOC104679443
uniprot id: A0A2K6NT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61622:PPIL3
gene id: 61622:PPIL3
uniprot id: A0A2K6P109
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:MRPL19
gene id: 61622:MRPL19
uniprot id: A0A2K6RJX9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

61622:NDUFA7
gene id: 61622:NDUFA7
uniprot id: A0A2K6R6U6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

61622:LOC104665158
gene id: 61622:LOC104665158
uniprot id: A0A2K6QTJ6
uniprot id: A0A2K6QTN3
names: Subcellular Location Annotation
messages: Cytoplasm

61622:DPEP1
gene id: 61622:DPEP1
uniprot id: A0A2K6RRQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

61622:ST8SIA3
gene id: 61622:ST8SIA3
uniprot id: A0A2K6NYI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:SMC5
gene id: 61622:SMC5
uniprot id: A0A2K6NUX1
uniprot id: A0A2K6NUX8
uniprot id: A0A2K6NUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

61622:TNFRSF4
gene id: 61622:TNFRSF4
uniprot id: A0A2K6RD68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:KRT7
gene id: 61622:KRT7
uniprot id: A0A2K6QYD7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PTPN12
gene id: 61622:PTPN12
uniprot id: A0A2K6PEA0
uniprot id: A0A2K6PEA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

61622:LOC104682480
gene id: 61622:LOC104682480
uniprot id: A0A2K6R8I0
names: Similarity
messages: Belongs to the apolipoprotein L family.

61622:TRAPPC3L
gene id: 61622:TRAPPC3L
uniprot id: A0A2K6QBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

61622:ABCB11
gene id: 61622:ABCB11
uniprot id: A0A2K6PY90
names: Subcellular Location Annotation
messages: Membrane

61622:NDUFAF4
gene id: 61622:NDUFAF4
uniprot id: A0A2K6PWU4
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

61622:INTU
gene id: 61622:INTU
uniprot id: A0A2K6PGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

61622:SF3B3
gene id: 61622:SF3B3
uniprot id: A0A2K6RX73
names: Subcellular Location Annotation
messages: Nucleus

61622:CCL21
gene id: 61622:CCL21
uniprot id: A0A2K6PQW0
names: Subcellular Location Annotation
messages: Secreted

61622:ADSL
gene id: 61622:ADSL
uniprot id: A0A2K6P3B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

61622:LOC104669219
gene id: 61622:LOC104669219
uniprot id: A0A2K6PWW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

61622:TUBD1
gene id: 61622:TUBD1
uniprot id: A0A2K6RXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

61622:SOAT1
gene id: 61622:SOAT1
uniprot id: A0A2K6Q3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ZAR1
gene id: 61622:ZAR1
uniprot id: A0A2K6NVB6
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

61622:SPI1
gene id: 61622:SPI1
uniprot id: A0A2K6RWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:POU6F2
gene id: 61622:POU6F2
uniprot id: A0A2K6Q213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61622:NAA10
gene id: 61622:NAA10
uniprot id: A0A2K6R768
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

61622:EGFL7
gene id: 61622:EGFL7
uniprot id: A0A2K6RCX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RPL8
gene id: 61622:RPL8
uniprot id: A0A2K6NSR2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

61622:NUDT3
gene id: 61622:NUDT3
uniprot id: A0A2K6NK56
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

61622:TUBGCP6
gene id: 61622:TUBGCP6
uniprot id: A0A2K6NHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: centrosome

61622:SLA
gene id: 61622:SLA
uniprot id: A0A2K6RV44
uniprot id: A0A2K6RV65
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LYNX1
gene id: 61622:LYNX1
uniprot id: A0A2K6QBM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SLC20A2
gene id: 61622:SLC20A2
uniprot id: A0A2K6QGC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

61622:SLC30A1
gene id: 61622:SLC30A1
uniprot id: A0A2K6RX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:PHKB
gene id: 61622:PHKB
uniprot id: A0A2K6PP62
uniprot id: A0A2K6PP74
uniprot id: A0A2K6PP95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

61622:SHBG
gene id: 61622:SHBG
uniprot id: A0A2K6R222
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TBRG1
gene id: 61622:TBRG1
uniprot id: A0A2K6QMM5
names: Subcellular Location Annotation
messages: Nucleus

61622:ALKBH8
gene id: 61622:ALKBH8
uniprot id: A0A2K6QS15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

61622:NRDC
gene id: 61622:NRDC
uniprot id: A0A2K6Q0M4
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:PGF
gene id: 61622:PGF
uniprot id: A0A2K6PW65
uniprot id: A0A2K6PW68
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

61622:DHRS7C
gene id: 61622:DHRS7C
uniprot id: A0A2K6RM50
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:HNRNPA3
gene id: 61622:HNRNPA3
uniprot id: A0A2K6NWS1
names: Subcellular Location Annotation
messages: Nucleus

61622:ETFA
gene id: 61622:ETFA
uniprot id: A0A2K6Q7Q3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

61622:ATF1
gene id: 61622:ATF1
uniprot id: A0A2K6PG40
names: Subcellular Location Annotation
messages: Nucleus

61622:ITGB3BP
gene id: 61622:ITGB3BP
uniprot id: A0A2K6R958
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

61622:EFNB3
gene id: 61622:EFNB3
uniprot id: A0A2K6RVU5
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PIGV
gene id: 61622:PIGV
uniprot id: A0A2K6RT85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

61622:SEZ6
gene id: 61622:SEZ6
uniprot id: A0A2K6RR24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HOXC10
gene id: 61622:HOXC10
uniprot id: A0A2K6REX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:KRT24
gene id: 61622:KRT24
uniprot id: A0A2K6NEL6
names: Similarity
messages: Belongs to the intermediate filament family.

61622:KPNA6
gene id: 61622:KPNA6
uniprot id: A0A2K6RTW7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:NPRL2
gene id: 61622:NPRL2
uniprot id: A0A2K6QWB5
names: Similarity
messages: Belongs to the NPR2 family.

61622:LOC104672173
gene id: 61622:LOC104672173
uniprot id: C9DEC7
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:ABCC12
gene id: 61622:ABCC12
uniprot id: A0A2K6PSF0
names: Subcellular Location Annotation
messages: Membrane

61622:SLC24A5
gene id: 61622:SLC24A5
uniprot id: A0A2K6QBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

61622:KCNK16
gene id: 61622:KCNK16
uniprot id: A0A2K6PWT2
uniprot id: A0A2K6PWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:ADORA2A
gene id: 61622:ADORA2A
uniprot id: A0A2K6NWI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

61622:GRWD1
gene id: 61622:GRWD1
uniprot id: A0A2K6R2Y8
names: Subcellular Location Annotation
messages: Nucleus

61622:SEMA3C
gene id: 61622:SEMA3C
uniprot id: A0A2K6RK06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:LOC104677288
gene id: 61622:LOC104677288
uniprot id: A0A2K6NR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MED7
gene id: 61622:MED7
uniprot id: A0A2K6NQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

61622:DHX9
gene id: 61622:DHX9
uniprot id: A0A2K6RQU6
uniprot id: A0A2K6RQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

61622:ICAM4
gene id: 61622:ICAM4
uniprot id: A0A2K6NY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:PSMB4
gene id: 61622:PSMB4
uniprot id: A0A2K6P367
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

61622:PPP6C
gene id: 61622:PPP6C
uniprot id: A0A2K6PCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

61622:BCL2A1
gene id: 61622:BCL2A1
uniprot id: A0A2K6PHG5
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:BBS2
gene id: 61622:BBS2
uniprot id: A0A2K6QUZ0
uniprot id: A0A2K6QUZ4
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

61622:MAP1LC3C
gene id: 61622:MAP1LC3C
uniprot id: A0A2K6N8I7
names: Similarity
messages: Belongs to the ATG8 family.

61622:LOC104668251
gene id: 61622:LOC104668251
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:KLC2
gene id: 61622:KLC2
uniprot id: A0A2K6Q4L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:CRELD1
gene id: 61622:CRELD1
uniprot id: A0A2K6NU36
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NOP58
gene id: 61622:NOP58
uniprot id: A0A2K6QI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus
messages: nucleoplasm

61622:FMO4
gene id: 61622:FMO4
uniprot id: A0A2K6PMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane

61622:SSH2
gene id: 61622:SSH2
uniprot id: A0A2K6NII3
uniprot id: A0A2K6NIJ5
uniprot id: A0A2K6NIJ6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

61622:LOC104670883
gene id: 61622:LOC104670883
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CLDN18
gene id: 61622:CLDN18
uniprot id: A0A2K6QZM5
uniprot id: A0A2K6QZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

61622:ABCC1
gene id: 61622:ABCC1
uniprot id: A0A2K6QY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:SLC44A1
gene id: 61622:SLC44A1
uniprot id: A0A2K6RBY1
uniprot id: A0A2K6RC49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

61622:ITGA8
gene id: 61622:ITGA8
uniprot id: A0A2K6RPE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:NUMB
gene id: 61622:NUMB
uniprot id: A0A2K6QSE2
uniprot id: A0A2K6QSF8
uniprot id: A0A2K6QSH1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

61622:DNMBP
gene id: 61622:DNMBP
uniprot id: A0A2K6NQA7
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

61622:APOA5
gene id: 61622:APOA5
uniprot id: A0A2K6R2V7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

61622:TMEM135
gene id: 61622:TMEM135
uniprot id: A0A2K6NRP8
uniprot id: A0A2K6NRQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

61622:IPMK
gene id: 61622:IPMK
uniprot id: A0A2K6Q4K6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:LOC104676970
gene id: 61622:LOC104676970
uniprot id: A0A2K6PNW2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

61622:CNTF
gene id: 61622:CNTF
uniprot id: A0A2K6P7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

61622:GRAMD1A
gene id: 61622:GRAMD1A
uniprot id: A0A2K6PAM0
uniprot id: A0A2K6PAW1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LRP10
gene id: 61622:LRP10
uniprot id: A0A2K6RT82
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ZDHHC14
gene id: 61622:ZDHHC14
uniprot id: A0A2K6QHF8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:AREG
gene id: 61622:AREG
uniprot id: A0A2K6RH80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DZIP3
gene id: 61622:DZIP3
uniprot id: A0A2K6QPA0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LCORL
gene id: 61622:LCORL
uniprot id: A0A2K6NNV4
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104677200
gene id: 61622:LOC104677200
uniprot id: A0A2K6NEA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:IL18R1
gene id: 61622:IL18R1
uniprot id: A0A2K6NKU7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:CDH8
gene id: 61622:CDH8
uniprot id: A0A2K6Q0T0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:VAMP8
gene id: 61622:VAMP8
uniprot id: A0A2K6QMY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:MANBAL
gene id: 61622:MANBAL
uniprot id: A0A2K6NHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

61622:ZFPL1
gene id: 61622:ZFPL1
uniprot id: A0A2K6ND94
uniprot id: A0A2K6NDA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

61622:PRPF18
gene id: 61622:PRPF18
uniprot id: A0A2K6QZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

61622:PHF5A
gene id: 61622:PHF5A
uniprot id: A0A2K6QNN6
names: Similarity
messages: Belongs to the PHF5 family.

61622:HNRNPF
gene id: 61622:HNRNPF
uniprot id: A0A2K6N7Y1
names: Subcellular Location Annotation
messages: nucleoplasm

61622:SNAP23
gene id: 61622:SNAP23
uniprot id: A0A2K6NY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

61622:RPL15
gene id: 61622:RPL15
uniprot id: A0A2K6NXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

61622:BRS3
gene id: 61622:BRS3
uniprot id: A0A2K6NXV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

61622:DSC2
gene id: 61622:DSC2
uniprot id: A0A2K6NMP8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:AMT
gene id: 61622:AMT
uniprot id: A0A2K6PE29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

61622:XK
gene id: 61622:XK
uniprot id: A0A2K6PDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61622:LOC104654533
gene id: 61622:LOC104654533
uniprot id: A0A2K6NJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:METTL16
gene id: 61622:METTL16
uniprot id: A0A2K6QEN7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

61622:LOC104680295
gene id: 61622:LOC104680295
uniprot id: A0A2K6NED8
names: Similarity
messages: Belongs to the NDK family.

61622:DEFB128
gene id: 61622:DEFB128
uniprot id: A0A2K6Q5F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:LOC104675518
gene id: 61622:LOC104675518
uniprot id: A0A2K6R5K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:TFPI2
gene id: 61622:TFPI2
uniprot id: A0A2K6R9B6
names: Subcellular Location Annotation
messages: Secreted

61622:ACTBL2
gene id: 61622:ACTBL2
uniprot id: A0A2K6NB39
names: Similarity
messages: Belongs to the actin family.

61622:LOC104659774
gene id: 61622:LOC104659774
uniprot id: A0A2K6QB15
names: Similarity
messages: Belongs to the histone H2B family.

61622:TSEN15
gene id: 61622:TSEN15
uniprot id: A0A2K6PZQ0
names: Similarity
messages: Belongs to the SEN15 family.

61622:CPSF6
gene id: 61622:CPSF6
uniprot id: A0A2K6RCS0
uniprot id: A0A2K6RCS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

61622:DARS2
gene id: 61622:DARS2
uniprot id: A0A2K6NXR6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

61622:KCNJ1
gene id: 61622:KCNJ1
uniprot id: A0A2K6RES0
uniprot id: A0A2K6RES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:TMEM94
gene id: 61622:TMEM94
uniprot id: A0A2K6Q6C7
names: Subcellular Location Annotation
messages: Membrane

61622:ZNF687
gene id: 61622:ZNF687
uniprot id: A0A2K6QDQ4
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:ITGB1
gene id: 61622:ITGB1
uniprot id: A0A2K6RRE3
uniprot id: A0A2K6RRF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

61622:SLC10A4
gene id: 61622:SLC10A4
uniprot id: A0A2K6N8F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:HSPA4L
gene id: 61622:HSPA4L
uniprot id: A0A2K6RK58
uniprot id: A0A2K6RK86
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:RPL37A
gene id: 61622:RPL37A
uniprot id: A0A2K6N7Q7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

61622:UBLCP1
gene id: 61622:UBLCP1
uniprot id: A0A2K6P4N8
names: Subcellular Location Annotation
messages: Nucleus

61622:SEMA7A
gene id: 61622:SEMA7A
uniprot id: A0A2K6RFR9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:VKORC1
gene id: 61622:VKORC1
uniprot id: A0A2K6RHX5
uniprot id: A0A2K6RI17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CCDC85B
gene id: 61622:CCDC85B
uniprot id: A0A2K6NAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

61622:WARS1
gene id: 61622:WARS1
uniprot id: A0A2K6NLL2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:CAPN1
gene id: 61622:CAPN1
uniprot id: A0A2K6R6K6
names: Similarity
messages: Belongs to the peptidase C2 family.

61622:IFI44L
gene id: 61622:IFI44L
uniprot id: A0A2K6Q755
names: Similarity
messages: Belongs to the IFI44 family.

61622:TSTA3
gene id: 61622:TSTA3
uniprot id: A0A2K6Q4E1
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

61622:HOXD13
gene id: 61622:HOXD13
uniprot id: A0A2K6QY09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:LPL
gene id: 61622:LPL
uniprot id: A0A2K6R7B5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

61622:SPAM1
gene id: 61622:SPAM1
uniprot id: A0A2K6P5Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

61622:CFL2
gene id: 61622:CFL2
uniprot id: A0A2K6QBL4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

61622:OLA1
gene id: 61622:OLA1
uniprot id: A0A2K6QL59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

61622:SRFBP1
gene id: 61622:SRFBP1
uniprot id: A0A2K6NS15
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

61622:BEST3
gene id: 61622:BEST3
uniprot id: A0A2K6QCV1
uniprot id: A0A2K6QCV9
uniprot id: A0A2K6QCW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

61622:AP3S1
gene id: 61622:AP3S1
uniprot id: A0A2K6NE38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

61622:KEG34 p11
gene id: 61622:KEG34_p11
uniprot id: Q15GP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:FADS2
gene id: 61622:FADS2
uniprot id: A0A2K6QZH9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TRMT1L
gene id: 61622:TRMT1L
uniprot id: A0A2K6PHP1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

61622:LSM7
gene id: 61622:LSM7
uniprot id: A0A2K6PUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

61622:SPCS2
gene id: 61622:SPCS2
uniprot id: A0A2K6NDN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PDE5A
gene id: 61622:PDE5A
uniprot id: A0A2K6QLA3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:RSPO1
gene id: 61622:RSPO1
uniprot id: A0A2K6R796
names: Similarity
messages: Belongs to the R-spondin family.

61622:CIAO1
gene id: 61622:CIAO1
uniprot id: A0A2K6QQE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

61622:OTOP1
gene id: 61622:OTOP1
uniprot id: A0A2K6NPV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61622:FGF4
gene id: 61622:FGF4
uniprot id: A0A2K6NVF5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:PANX2
gene id: 61622:PANX2
uniprot id: A0A2K6QFK2
uniprot id: A0A2K6QFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61622:ZNF213
gene id: 61622:ZNF213
uniprot id: A0A2K6PND2
names: Subcellular Location Annotation
messages: Nucleus

61622:ACTN2
gene id: 61622:ACTN2
uniprot id: A0A2K6NUW3
names: Similarity
messages: Belongs to the alpha-actinin family.

61622:SLC15A3
gene id: 61622:SLC15A3
uniprot id: A0A2K6NSE2
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

61622:LOC104672608
gene id: 61622:LOC104672608
uniprot id: A0A2K6NP49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:E2F7
gene id: 61622:E2F7
uniprot id: A0A2K6PFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:SOD3
gene id: 61622:SOD3
uniprot id: A0A2K6NKP3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

61622:ADAM8
gene id: 61622:ADAM8
uniprot id: A0A2K6QJY9
uniprot id: A0A2K6QK01
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:DERL1
gene id: 61622:DERL1
uniprot id: A0A2K6RKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

61622:CASQ2
gene id: 61622:CASQ2
uniprot id: A0A2K6PIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

61622:FGF12
gene id: 61622:FGF12
uniprot id: A0A2K6P9Y0
uniprot id: A0A2K6P9Y5
uniprot id: A0A2K6PA02
uniprot id: A0A2K6PA10
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:SLC5A8
gene id: 61622:SLC5A8
uniprot id: A0A2K6Q401
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:UBE2D3
gene id: 61622:UBE2D3
uniprot id: A0A2K6PHZ2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PES1
gene id: 61622:PES1
uniprot id: A0A2K6NWN2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

61622:LOC104675517
gene id: 61622:LOC104675517
uniprot id: A0A2K6Q299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:GATA2
gene id: 61622:GATA2
uniprot id: A0A2K6RED9
names: Subcellular Location Annotation
messages: Nucleus

61622:LEAP2
gene id: 61622:LEAP2
uniprot id: A0A2K6R8T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

61622:PDCD5
gene id: 61622:PDCD5
uniprot id: A0A2K6QVW2
uniprot id: A0A2K6QW11
names: Similarity
messages: Belongs to the PDCD5 family.

61622:TMEM47
gene id: 61622:TMEM47
uniprot id: A0A2K6RBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

61622:NFE2
gene id: 61622:NFE2
uniprot id: A0A2K6PFU1
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

61622:WNT10B
gene id: 61622:WNT10B
uniprot id: A0A2K6RSD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:COMTD1
gene id: 61622:COMTD1
uniprot id: A0A2K6REV3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

61622:HAUS1
gene id: 61622:HAUS1
uniprot id: A0A2K6QD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

61622:CSNK2B
gene id: 61622:CSNK2B
uniprot id: A0A2K6RNQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

61622:LOC104666621
gene id: 61622:LOC104666621
uniprot id: A0A2K6QH37
names: Similarity
messages: Belongs to the MHC class II family.

61622:DNASE2
gene id: 61622:DNASE2
uniprot id: A0A2K6P3L0
names: Similarity
messages: Belongs to the DNase II family.

61622:MAP3K8
gene id: 61622:MAP3K8
uniprot id: A0A2K6RPG4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

61622:IDS
gene id: 61622:IDS
uniprot id: A0A2K6Q6K4
names: Similarity
messages: Belongs to the sulfatase family.

61622:FDXR
gene id: 61622:FDXR
uniprot id: A0A2K6R7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

61622:KCNA3
gene id: 61622:KCNA3
uniprot id: A0A2K6N7U7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:RXFP4
gene id: 61622:RXFP4
uniprot id: A0A2K6NGI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:GTF3C5
gene id: 61622:GTF3C5
uniprot id: A0A2K6QN67
names: Subcellular Location Annotation
messages: Nucleus

61622:CD37
gene id: 61622:CD37
uniprot id: A0A2K6QD49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TES
gene id: 61622:TES
uniprot id: A0A2K6NJL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

61622:CACFD1
gene id: 61622:CACFD1
uniprot id: A0A2K6NGH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

61622:IFI6
gene id: 61622:IFI6
uniprot id: A0A2K6NTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

61622:MRPL47
gene id: 61622:MRPL47
uniprot id: A0A2K6PU94
uniprot id: A0A2K6PU98
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

61622:TTC9B
gene id: 61622:TTC9B
uniprot id: A0A2K6PQE0
names: Similarity
messages: Belongs to the TTC9 family.

61622:CTLA4
gene id: 61622:CTLA4
uniprot id: A0A2K6NVC8
uniprot id: A0A2K6NVC9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

61622:AWAT1
gene id: 61622:AWAT1
uniprot id: A0A2K6NW39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

61622:CDC37L1
gene id: 61622:CDC37L1
uniprot id: A0A2K6Q9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

61622:LOC104676337
gene id: 61622:LOC104676337
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:FGF19
gene id: 61622:FGF19
uniprot id: A0A2K6PJR3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:CTSC
gene id: 61622:CTSC
uniprot id: A0A2K6NZ23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

61622:SESN3
gene id: 61622:SESN3
uniprot id: A0A2K6NQ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

61622:API5
gene id: 61622:API5
uniprot id: A0A2K6RRF8
names: Similarity
messages: Belongs to the API5 family.

61622:RELL1
gene id: 61622:RELL1
uniprot id: A0A2K6NDL3
names: Similarity
messages: Belongs to the RELT family.

61622:RPN1
gene id: 61622:RPN1
uniprot id: A0A2K6N7K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61622:MARVELD2
gene id: 61622:MARVELD2
uniprot id: A0A2K6PM38
uniprot id: A0A2K6PM94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

61622:KHDRBS3
gene id: 61622:KHDRBS3
uniprot id: A0A2K6RR42
names: Similarity
messages: Belongs to the KHDRBS family.

61622:PRKAB2
gene id: 61622:PRKAB2
uniprot id: A0A2K6NK61
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

61622:SAR1B
gene id: 61622:SAR1B
uniprot id: A0A2K6NX08
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

61622:ITGB2
gene id: 61622:ITGB2
uniprot id: A0A2K6RN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

61622:FERMT3
gene id: 61622:FERMT3
uniprot id: A0A2K6NJJ1
names: Similarity
messages: Belongs to the kindlin family.

61622:SHROOM4
gene id: 61622:SHROOM4
uniprot id: A0A2K6R034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

61622:CORO1C
gene id: 61622:CORO1C
uniprot id: A0A2K6NJ88
names: Similarity
messages: Belongs to the WD repeat coronin family.

61622:TRAPPC2
gene id: 61622:TRAPPC2
uniprot id: A0A2K6P2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

61622:C1GALT1
gene id: 61622:C1GALT1
uniprot id: A0A2K6NXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

61622:ANXA6
gene id: 61622:ANXA6
uniprot id: A0A2K6NX26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

61622:LOC104676095
gene id: 61622:LOC104676095
uniprot id: A0A2K6NW88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:AQP4
gene id: 61622:AQP4
uniprot id: A0A2K6QWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:CCDC167
gene id: 61622:CCDC167
uniprot id: A0A2K6PFE6
names: Subcellular Location Annotation
messages: Membrane

61622:SEC24A
gene id: 61622:SEC24A
uniprot id: A0A2K6RWZ6
uniprot id: A0A2K6RX01
uniprot id: A0A2K6RX03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:DCTN6
gene id: 61622:DCTN6
uniprot id: A0A2K6QMT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

61622:SMARCA1
gene id: 61622:SMARCA1
uniprot id: A0A2K6PVI8
uniprot id: A0A2K6PVK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

61622:GUCA2A
gene id: 61622:GUCA2A
uniprot id: A0A2K6NKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

61622:INKA2
gene id: 61622:INKA2
uniprot id: A0A2K6NPF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

61622:FGF11
gene id: 61622:FGF11
uniprot id: A0A2K6NG87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:VDAC1
gene id: 61622:VDAC1
uniprot id: A0A2K6NQM2
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

61622:EIF2B2
gene id: 61622:EIF2B2
uniprot id: A0A2K6RCQ2
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

61622:DBNL
gene id: 61622:DBNL
uniprot id: A0A2K6R0G6
uniprot id: A0A2K6R0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

61622:LOC104653549
gene id: 61622:LOC104653549
uniprot id: A0A2K6P939
names: Subcellular Location Annotation
messages: Membrane

61622:ARPC5L
gene id: 61622:ARPC5L
uniprot id: A0A2K6R2D3
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

61622:JMY
gene id: 61622:JMY
uniprot id: A0A2K6PD34
names: Subcellular Location Annotation
messages: Membrane

61622:FLOT2
gene id: 61622:FLOT2
uniprot id: A0A2K6PCK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

61622:LOC104658880
gene id: 61622:LOC104658880
uniprot id: A0A2K6NCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:MOGS
gene id: 61622:MOGS
uniprot id: A0A2K6N954
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

61622:USP1
gene id: 61622:USP1
uniprot id: A0A2K6NUZ2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:SLC2A6
gene id: 61622:SLC2A6
uniprot id: A0A2K6QN88
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:ATP6V1A
gene id: 61622:ATP6V1A
uniprot id: A0A2K6NB34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Vesicle
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

61622:TOP1
gene id: 61622:TOP1
uniprot id: A0A2K6RG36
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

61622:DDB1
gene id: 61622:DDB1
uniprot id: A0A2K6R4S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

61622:UCMA
gene id: 61622:UCMA
uniprot id: A0A2K6NIL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

61622:GYS1
gene id: 61622:GYS1
uniprot id: A0A2K6PY65
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

61622:ADAMTS15
gene id: 61622:ADAMTS15
uniprot id: A0A2K6QSB6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:ENO2
gene id: 61622:ENO2
uniprot id: A0A2K6PCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

61622:B4GALT5
gene id: 61622:B4GALT5
uniprot id: A0A2K6NUV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:ZFHX4
gene id: 61622:ZFHX4
uniprot id: A0A2K6PCE4
names: Subcellular Location Annotation
messages: Nucleus

61622:ROGDI
gene id: 61622:ROGDI
uniprot id: A0A2K6QKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Presynapse
messages: Vesicle
messages: synaptic vesicle

61622:LOC104656391
gene id: 61622:LOC104656391
uniprot id: A0A2K6NLN9
names: Subcellular Location Annotation
messages: Membrane

61622:SUDS3
gene id: 61622:SUDS3
uniprot id: A0A2K6R6I1
names: Subcellular Location Annotation
messages: Nucleus

61622:AQP6
gene id: 61622:AQP6
uniprot id: A0A2K6NB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:PLA2G15
gene id: 61622:PLA2G15
uniprot id: A0A2K6Q795
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:LOC104672955
gene id: 61622:LOC104672955
uniprot id: A0A2K6Q4U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:UBR1
gene id: 61622:UBR1
uniprot id: A0A2K6P597
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

61622:GPNMB
gene id: 61622:GPNMB
uniprot id: A0A2K6REY5
names: Similarity
messages: Belongs to the PMEL/NMB family.

61622:PMS1
gene id: 61622:PMS1
uniprot id: A0A2K6PXL1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

61622:LDLRAD2
gene id: 61622:LDLRAD2
uniprot id: A0A2K6P356
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MOCOS
gene id: 61622:MOCOS
uniprot id: A0A2K6NQ86
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

61622:PPP2R5C
gene id: 61622:PPP2R5C
uniprot id: A0A2K6RB52
uniprot id: A0A2K6RB64
uniprot id: A0A2K6RB76
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:GMPR
gene id: 61622:GMPR
uniprot id: A0A2K6R131
uniprot id: A0A2K6R144
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PAX2
gene id: 61622:PAX2
uniprot id: A0A2K6Q8S0
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC6A11
gene id: 61622:SLC6A11
uniprot id: A0A2K6PD86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:SF3B6
gene id: 61622:SF3B6
uniprot id: A0A2K6NEX9
names: Subcellular Location Annotation
messages: Nucleus

61622:IMMT
gene id: 61622:IMMT
uniprot id: A0A2K6NN72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

61622:NPM1
gene id: 61622:NPM1
uniprot id: A0A2K6RTJ9
uniprot id: A0A2K6RTL7
names: Similarity
messages: Belongs to the nucleoplasmin family.

61622:USP16
gene id: 61622:USP16
uniprot id: A0A2K6QQL1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

61622:POLRMT
gene id: 61622:POLRMT
uniprot id: A0A2K6R0G2
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:CXCR4
gene id: 61622:CXCR4
uniprot id: A0A2K6P0L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

61622:CSF3
gene id: 61622:CSF3
uniprot id: A0A2K6P8H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

61622:MTERF2
gene id: 61622:MTERF2
uniprot id: A0A2K6NA57
names: Similarity
messages: Belongs to the mTERF family.

61622:SPATA20
gene id: 61622:SPATA20
uniprot id: A0A2K6R9M3
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

61622:SCRN3
gene id: 61622:SCRN3
uniprot id: A0A2K6RSN6
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

61622:CSTA
gene id: 61622:CSTA
uniprot id: A0A2K6RAC8
names: Similarity
messages: Belongs to the cystatin family.

61622:F11R
gene id: 61622:F11R
uniprot id: A0A2K6RGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

61622:HCN3
gene id: 61622:HCN3
uniprot id: A0A2K6R2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

61622:PTPRB
gene id: 61622:PTPRB
uniprot id: A0A2K6NEY8
uniprot id: A0A2K6NEZ1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

61622:LIPN
gene id: 61622:LIPN
uniprot id: A0A2K6RCL6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:CCT8
gene id: 61622:CCT8
uniprot id: A0A2K6P9R6
uniprot id: A0A2K6P9S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: cilium basal body

61622:GRPEL1
gene id: 61622:GRPEL1
uniprot id: A0A2K6NEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

61622:ETFDH
gene id: 61622:ETFDH
uniprot id: A0A2K6PUT4
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

61622:DUSP1
gene id: 61622:DUSP1
uniprot id: A0A2K6NTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

61622:TACR2
gene id: 61622:TACR2
uniprot id: A0A2K6QVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ADAM7
gene id: 61622:ADAM7
uniprot id: A0A2K6P933
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PALM
gene id: 61622:PALM
uniprot id: A0A2K6NW52
names: Similarity
messages: Belongs to the paralemmin family.

61622:HMGCR
gene id: 61622:HMGCR
uniprot id: A0A2K6QV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

61622:PDIK1L
gene id: 61622:PDIK1L
uniprot id: A0A2K6P0M6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:CCDC47
gene id: 61622:CCDC47
uniprot id: A0A2K6NC51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

61622:CHCHD6
gene id: 61622:CHCHD6
uniprot id: A0A2K6P8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61622:LLPH
gene id: 61622:LLPH
uniprot id: A0A2K6RLY5
names: Similarity
messages: Belongs to the learning-associated protein family.

61622:HAL
gene id: 61622:HAL
uniprot id: A0A2K6PWY5
uniprot id: A0A2K6PWY8
names: Similarity
messages: Belongs to the PAL/histidase family.

61622:INSL4
gene id: 61622:INSL4
uniprot id: A0A2K6R335
names: Subcellular Location Annotation
messages: Secreted

61622:LOC104663672
gene id: 61622:LOC104663672
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:BET1L
gene id: 61622:BET1L
uniprot id: A0A2K6NWD0
names: Subcellular Location Annotation
messages: Membrane

61622:DEFB114
gene id: 61622:DEFB114
uniprot id: A0A2K6R389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:PLXNA3
gene id: 61622:PLXNA3
uniprot id: A0A2K6RRW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FABP12
gene id: 61622:FABP12
uniprot id: A0A2K6QKU5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:CBLB
gene id: 61622:CBLB
uniprot id: A0A2K6RJ27
uniprot id: A0A2K6RJ34
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

61622:NOL11
gene id: 61622:NOL11
uniprot id: A0A2K6N8X7
names: Subcellular Location Annotation
messages: nucleolus

61622:TMPRSS11B
gene id: 61622:TMPRSS11B
uniprot id: A0A2K6PBD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:MBLAC1
gene id: 61622:MBLAC1
uniprot id: A0A2K6NMR2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:PPP2CA
gene id: 61622:PPP2CA
uniprot id: A0A2K6Q869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

61622:LOC104659598
gene id: 61622:LOC104659598
uniprot id: A0A2K6NEM7
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: Exhibits phosphohistidine phosphatase activity.

61622:CACNG6
gene id: 61622:CACNG6
uniprot id: A0A2K6RB03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

61622:SLC5A9
gene id: 61622:SLC5A9
uniprot id: A0A2K6RMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:ASF1A
gene id: 61622:ASF1A
uniprot id: A0A2K6NET8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

61622:DES
gene id: 61622:DES
uniprot id: A0A2K6PHA2
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PYROXD1
gene id: 61622:PYROXD1
uniprot id: A0A2K6NGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

61622:STARD5
gene id: 61622:STARD5
uniprot id: A0A2K6RXW9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61622:MEIS3
gene id: 61622:MEIS3
uniprot id: A0A2K6NY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

61622:FGF9
gene id: 61622:FGF9
uniprot id: A0A2K6PV23
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:TACC1
gene id: 61622:TACC1
uniprot id: A0A2K6QHZ6
uniprot id: A0A2K6QHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

61622:ADH7
gene id: 61622:ADH7
uniprot id: A0A2K6NKU1
uniprot id: A0A2K6NKU8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61622:KALRN
gene id: 61622:KALRN
uniprot id: A0A2K6RU39
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

61622:GFM1
gene id: 61622:GFM1
uniprot id: A0A2K6PAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

61622:ITGA1
gene id: 61622:ITGA1
uniprot id: A0A2K6P7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:RRAGA
gene id: 61622:RRAGA
uniprot id: A0A2K6N8Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

61622:MFSD14A
gene id: 61622:MFSD14A
uniprot id: A0A2K6Q7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61622:RIOK3
gene id: 61622:RIOK3
uniprot id: A0A2K6RX94
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

61622:CMAS
gene id: 61622:CMAS
uniprot id: A0A2K6QIF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

61622:LOC104662359
gene id: 61622:LOC104662359
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:LOC104674019
gene id: 61622:LOC104674019
uniprot id: A0A2K6NFQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:CDC5L
gene id: 61622:CDC5L
uniprot id: A0A2K6NZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

61622:SLC25A4
gene id: 61622:SLC25A4
uniprot id: A0A2K6Q1W5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

61622:SH3BP4
gene id: 61622:SH3BP4
uniprot id: A0A2K6PDD8
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

61622:OASL
gene id: 61622:OASL
uniprot id: A0A2K6Q5U6
names: Similarity
messages: Belongs to the 2-5A synthase family.

61622:NDUFS7
gene id: 61622:NDUFS7
uniprot id: A0A2K6NTJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 20 kDa subunit family.
messages: Mitochondrion inner membrane

61622:VPS37B
gene id: 61622:VPS37B
uniprot id: A0A2K6R6A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:LOC104668952
gene id: 61622:LOC104668952
uniprot id: A0A2K6NIU3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

61622:DRC1
gene id: 61622:DRC1
uniprot id: A0A2K6RXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

61622:COPS7B
gene id: 61622:COPS7B
uniprot id: A0A2K6QH94
uniprot id: A0A2K6QHB8
uniprot id: A0A2K6QHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

61622:PROX2
gene id: 61622:PROX2
uniprot id: A0A2K6PU03
uniprot id: A0A2K6PU14
names: Subcellular Location Annotation
messages: Nucleus

61622:ITIH4
gene id: 61622:ITIH4
uniprot id: A0A2K6PB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:MRPS15
gene id: 61622:MRPS15
uniprot id: A0A2K6RVB2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

61622:CNDP2
gene id: 61622:CNDP2
uniprot id: A0A2K6NS80
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

61622:LOC104680020
gene id: 61622:LOC104680020
uniprot id: A0A2K6PNY8
names: Similarity
messages: Belongs to the SPATA31 family.

61622:LOC104657557
gene id: 61622:LOC104657557
uniprot id: A0A2K6Q2L3
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

61622:MARCHF9
gene id: 61622:MARCHF9
uniprot id: A0A2K6Q954
names: Subcellular Location Annotation
messages: Membrane

61622:SLC25A25
gene id: 61622:SLC25A25
uniprot id: A0A2K6RWG7
uniprot id: A0A2K6RWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:EML4
gene id: 61622:EML4
uniprot id: A0A2K6Q8N8
names: Similarity
messages: Belongs to the WD repeat EMAP family.

61622:SEMA3F
gene id: 61622:SEMA3F
uniprot id: A0A2K6PT67
uniprot id: A0A2K6PT73
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:VANGL2
gene id: 61622:VANGL2
uniprot id: A0A2K6RW82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

61622:LOC104665939
gene id: 61622:LOC104665939
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:CACYBP
gene id: 61622:CACYBP
uniprot id: A0A2K6PKP1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

61622:MGA
gene id: 61622:MGA
uniprot id: A0A2K6P2W6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:CNTNAP5
gene id: 61622:CNTNAP5
uniprot id: A0A2K6QQ91
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TMEM267
gene id: 61622:TMEM267
uniprot id: A0A2K6Q9P0
names: Subcellular Location Annotation
messages: Membrane

61622:MMAA
gene id: 61622:MMAA
uniprot id: A0A2K6NWW1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

61622:SCD5
gene id: 61622:SCD5
uniprot id: A0A2K6QJA3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

61622:CASKIN2
gene id: 61622:CASKIN2
uniprot id: A0A2K6PR28
names: Subcellular Location Annotation
messages: Cytoplasm

61622:NR2C1
gene id: 61622:NR2C1
uniprot id: A0A2K6RWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:KCNE2
gene id: 61622:KCNE2
uniprot id: A0A2K6N994
names: Similarity
messages: Belongs to the potassium channel KCNE family.

61622:TMEM151A
gene id: 61622:TMEM151A
uniprot id: A0A2K6QNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

61622:CACUL1
gene id: 61622:CACUL1
uniprot id: A0A2K6Q8Z3
names: Similarity
messages: Belongs to the cullin family.

61622:LOC104661013
gene id: 61622:LOC104661013
uniprot id: A0A2K6NCI6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:ZCCHC4
gene id: 61622:ZCCHC4
uniprot id: A0A2K6N949
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

61622:DYNLT1
gene id: 61622:DYNLT1
uniprot id: A0A2K6QCW4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:CAMK2N1
gene id: 61622:CAMK2N1
uniprot id: A0A2K6PB86
names: Similarity
messages: Belongs to the CAMK2N family.

61622:ORC5
gene id: 61622:ORC5
uniprot id: A0A2K6PSK8
names: Subcellular Location Annotation
messages: Nucleus

61622:CDNF
gene id: 61622:CDNF
uniprot id: A0A2K6R8P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

61622:PEMT
gene id: 61622:PEMT
uniprot id: A0A2K6NSW8
uniprot id: A0A2K6NSY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

61622:BRK1
gene id: 61622:BRK1
uniprot id: A0A2K6QBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

61622:DOCK11
gene id: 61622:DOCK11
uniprot id: A0A2K6R3N2
names: Similarity
messages: Belongs to the DOCK family.

61622:P4HA3
gene id: 61622:P4HA3
uniprot id: A0A2K6P8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:TM4SF1
gene id: 61622:TM4SF1
uniprot id: A0A2K6NT77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:ANXA11
gene id: 61622:ANXA11
uniprot id: A0A2K6NKI5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61622:KBTBD8
gene id: 61622:KBTBD8
uniprot id: A0A2K6QS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

61622:LOC104655384
gene id: 61622:LOC104655384
uniprot id: A0A2K6RLV0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:FAM229B
gene id: 61622:FAM229B
uniprot id: A0A2K6NTT5
names: Similarity
messages: Belongs to the FAM229 family.

61622:MAPT
gene id: 61622:MAPT
uniprot id: A0A2K6RJQ1
uniprot id: A0A2K6RJQ9
uniprot id: A0A2K6RJS0
uniprot id: A0A2K6RJS2
uniprot id: A0A2K6RJT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

61622:LOC104656671
gene id: 61622:LOC104656671
uniprot id: A0A2K6NZ76
uniprot id: A0A2K6NZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

61622:TULP1
gene id: 61622:TULP1
uniprot id: A0A2K6P292
names: Similarity
messages: Belongs to the TUB family.

61622:RGMA
gene id: 61622:RGMA
uniprot id: A0A2K6PT26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61622:PIGP
gene id: 61622:PIGP
uniprot id: A0A2K6QAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

61622:ARFGEF2
gene id: 61622:ARFGEF2
uniprot id: A0A2K6RFI0
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

61622:LOC104662335
gene id: 61622:LOC104662335
uniprot id: A0A2K6NCH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LIPC
gene id: 61622:LIPC
uniprot id: A0A2K6PZI4
uniprot id: A0A2K6PZJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CCR5
gene id: 61622:CCR5
uniprot id: Q7JJ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:TRMU
gene id: 61622:TRMU
uniprot id: A0A2K6NA23
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

61622:MTERF1
gene id: 61622:MTERF1
uniprot id: A0A2K6PC18
names: Similarity
messages: Belongs to the mTERF family.

61622:P4HA2
gene id: 61622:P4HA2
uniprot id: A0A2K6R3W4
uniprot id: A0A2K6R3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:GRPR
gene id: 61622:GRPR
uniprot id: A0A2K6Q5D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CCN6
gene id: 61622:CCN6
uniprot id: A0A2K6R3L3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:KCNMB4
gene id: 61622:KCNMB4
uniprot id: A0A2K6Q2X1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

61622:MSH2
gene id: 61622:MSH2
uniprot id: A0A2K6N8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

61622:LOC104681097
gene id: 61622:LOC104681097
uniprot id: A0A2K6NRI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MAN2B2
gene id: 61622:MAN2B2
uniprot id: A0A2K6R7L4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

61622:BCKDK
gene id: 61622:BCKDK
uniprot id: A0A2K6N903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:ALOX5
gene id: 61622:ALOX5
uniprot id: A0A2K6NVJ9
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:FBN1
gene id: 61622:FBN1
uniprot id: A0A2K6QFN9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:PDCD4
gene id: 61622:PDCD4
uniprot id: A0A2K6RAP0
names: Similarity
messages: Belongs to the PDCD4 family.

61622:TSPAN14
gene id: 61622:TSPAN14
uniprot id: A0A2K6R645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:TAF15
gene id: 61622:TAF15
uniprot id: A0A2K6P0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

61622:HACD3
gene id: 61622:HACD3
uniprot id: A0A2K6NQ62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PDX1
gene id: 61622:PDX1
uniprot id: A0A2K6QMQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:PAPOLA
gene id: 61622:PAPOLA
uniprot id: A0A2K6NQG3
uniprot id: A0A2K6NQH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

61622:MAP2K4
gene id: 61622:MAP2K4
uniprot id: A0A2K6PJ79
uniprot id: A0A2K6PJ85
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:NEU3
gene id: 61622:NEU3
uniprot id: A0A2K6NYF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:HOXA1
gene id: 61622:HOXA1
uniprot id: A0A2K6RD38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

61622:BPNT1
gene id: 61622:BPNT1
uniprot id: A0A2K6NYR3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:EMX2
gene id: 61622:EMX2
uniprot id: A0A2K6RWM0
names: Subcellular Location Annotation
messages: Nucleus

61622:MRFAP1L1
gene id: 61622:MRFAP1L1
uniprot id: A0A2K6NGS9
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

61622:GPX5
gene id: 61622:GPX5
uniprot id: A0A2K6NT00
uniprot id: A0A2K6NT12
names: Similarity
messages: Belongs to the glutathione peroxidase family.

61622:VEGFC
gene id: 61622:VEGFC
uniprot id: A0A2K6P1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

61622:PIH1D2
gene id: 61622:PIH1D2
uniprot id: A0A2K6PN05
names: Similarity
messages: Belongs to the PIH1 family.

61622:BTG2
gene id: 61622:BTG2
uniprot id: A0A2K6N9H0
names: Similarity
messages: Belongs to the BTG family.

61622:TVP23A
gene id: 61622:TVP23A
uniprot id: A0A2K6NU37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

61622:CD93
gene id: 61622:CD93
uniprot id: A0A2K6NFH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SLAIN2
gene id: 61622:SLAIN2
uniprot id: A0A2K6P0Y7
uniprot id: A0A2K6P0Z3
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

61622:TTC26
gene id: 61622:TTC26
uniprot id: A0A2K6PCG7
names: Similarity
messages: Belongs to the IFT56 family.

61622:CWC15
gene id: 61622:CWC15
uniprot id: A0A2K6QDL3
names: Similarity
messages: Belongs to the CWC15 family.

61622:TNFRSF1A
gene id: 61622:TNFRSF1A
uniprot id: A0A2K6NYW5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104671863
gene id: 61622:LOC104671863
uniprot id: A0A2K6NAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61622:INTS3
gene id: 61622:INTS3
uniprot id: A0A2K6PKC5
uniprot id: A0A2K6PKE6
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

61622:MOB3B
gene id: 61622:MOB3B
uniprot id: A0A2K6R0E6
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:TM2D3
gene id: 61622:TM2D3
uniprot id: A0A2K6RUH2
uniprot id: A0A2K6RUI1
names: Subcellular Location Annotation
messages: Membrane

61622:CDK5
gene id: 61622:CDK5
uniprot id: A0A2K6PSN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LYRM1
gene id: 61622:LYRM1
uniprot id: A0A2K6RAA7
names: Similarity
messages: Belongs to the complex I LYR family.

61622:LZTS2
gene id: 61622:LZTS2
uniprot id: A0A2K6RP64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

61622:KCNK9
gene id: 61622:KCNK9
uniprot id: A0A2K6P0B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

61622:ANAPC2
gene id: 61622:ANAPC2
uniprot id: A0A2K6Q5E2
names: Similarity
messages: Belongs to the cullin family.

61622:SEC11A
gene id: 61622:SEC11A
uniprot id: A0A2K6QPB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:UGGT2
gene id: 61622:UGGT2
uniprot id: A0A2K6QS50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

61622:LOC104670080
gene id: 61622:LOC104670080
uniprot id: A0A2K6NGI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:WDR55
gene id: 61622:WDR55
uniprot id: A0A2K6R5Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

61622:CREB1
gene id: 61622:CREB1
uniprot id: A0A2K6Q2B5
uniprot id: A0A2K6Q2B9
names: Subcellular Location Annotation
messages: Nucleus

61622:PPP2R3C
gene id: 61622:PPP2R3C
uniprot id: A0A2K6QTE7
names: Subcellular Location Annotation
messages: Nucleus

61622:FAM160A1
gene id: 61622:FAM160A1
uniprot id: A0A2K6PBE0
names: Similarity
messages: Belongs to the FHIP family.

61622:CUEDC2
gene id: 61622:CUEDC2
uniprot id: A0A2K6RMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

61622:MYSM1
gene id: 61622:MYSM1
uniprot id: A0A2K6PIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

61622:CLDN7
gene id: 61622:CLDN7
uniprot id: A0A2K6PEJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:LOC104663468
gene id: 61622:LOC104663468
uniprot id: A0A2K6NMG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104666003
gene id: 61622:LOC104666003
uniprot id: A0A2K6NS74
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:C20H16orf58
gene id: 61622:C20H16orf58
uniprot id: A0A2K6RS71
names: Similarity
messages: Belongs to the RUS1 family.

61622:MOB3C
gene id: 61622:MOB3C
uniprot id: A0A2K6QJ27
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:UPF3B
gene id: 61622:UPF3B
uniprot id: A0A2K6R1U0
uniprot id: A0A2K6R1X1
names: Similarity
messages: Belongs to the RENT3 family.

61622:PPIP5K2
gene id: 61622:PPIP5K2
uniprot id: A0A2K6R7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

61622:PYGB
gene id: 61622:PYGB
uniprot id: A0A2K6Q4J6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

61622:NDNF
gene id: 61622:NDNF
uniprot id: A0A2K6PQ18
names: Subcellular Location Annotation
messages: Secreted

61622:CEP57
gene id: 61622:CEP57
uniprot id: A0A2K6NL09
names: Similarity
messages: Belongs to the translokin family.

61622:STXBP1
gene id: 61622:STXBP1
uniprot id: A0A2K6NG89
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61622:SEMA4C
gene id: 61622:SEMA4C
uniprot id: A0A2K6N7T2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:COQ8B
gene id: 61622:COQ8B
uniprot id: A0A2K6QWI7
uniprot id: A0A2K6QWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

61622:PA2G4
gene id: 61622:PA2G4
uniprot id: A0A2K6NBE1
names: Similarity
messages: Belongs to the peptidase M24 family.

61622:CENPO
gene id: 61622:CENPO
uniprot id: A0A2K6RCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

61622:LOC104674017
gene id: 61622:LOC104674017
uniprot id: A0A2K6NFQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:EIF2B1
gene id: 61622:EIF2B1
uniprot id: A0A2K6NUL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

61622:TECPR1
gene id: 61622:TECPR1
uniprot id: A0A2K6Q1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

61622:RHPN2
gene id: 61622:RHPN2
uniprot id: A0A2K6NAH3
names: Similarity
messages: Belongs to the RHPN family.

61622:PRKRA
gene id: 61622:PRKRA
uniprot id: A0A2K6Q2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

61622:NMU
gene id: 61622:NMU
uniprot id: A0A2K6Q3J0
uniprot id: A0A2K6Q3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

61622:ERO1B
gene id: 61622:ERO1B
uniprot id: A0A2K6Q1T4
uniprot id: A0A2K6Q1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

61622:GPR135
gene id: 61622:GPR135
uniprot id: A0A2K6NTF9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:RNF112
gene id: 61622:RNF112
uniprot id: A0A2K6Q0P3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:LOC104670642
gene id: 61622:LOC104670642
uniprot id: A0A2K6R1C5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SLCO1B3
gene id: 61622:SLCO1B3
uniprot id: A0A2K6QNX2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:HDDC2
gene id: 61622:HDDC2
uniprot id: A0A2K6PRK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

61622:DOK1
gene id: 61622:DOK1
uniprot id: A0A2K6QX64
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

61622:C10H12orf65
gene id: 61622:C10H12orf65
uniprot id: A0A2K6PCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

61622:ZFYVE28
gene id: 61622:ZFYVE28
uniprot id: A0A2K6NRX2
names: Similarity
messages: Belongs to the lst-2 family.

61622:SLC18A3
gene id: 61622:SLC18A3
uniprot id: A0A2K6QFI6
names: Subcellular Location Annotation
messages: Membrane

61622:GRN
gene id: 61622:GRN
uniprot id: A0A2K6NI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

61622:POLR2M
gene id: 61622:POLR2M
uniprot id: A0A2K6RD86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

61622:POMGNT1
gene id: 61622:POMGNT1
uniprot id: A0A2K6RUY2
uniprot id: A0A2K6RUY5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

61622:BCL2L13
gene id: 61622:BCL2L13
uniprot id: A0A2K6PJW0
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:ERLIN1
gene id: 61622:ERLIN1
uniprot id: A0A2K6RB38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

61622:ACTR8
gene id: 61622:ACTR8
uniprot id: A0A2K6RCA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

61622:SLC13A4
gene id: 61622:SLC13A4
uniprot id: A0A2K6RBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:IZUMO4
gene id: 61622:IZUMO4
uniprot id: A0A2K6R9Y0
names: Similarity
messages: Belongs to the Izumo family.

61622:IFITM5
gene id: 61622:IFITM5
uniprot id: A0A2K6NJN0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:ETV3
gene id: 61622:ETV3
uniprot id: A0A2K6RAG0
uniprot id: A0A2K6RAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:LOC104668621
gene id: 61622:LOC104668621
uniprot id: A0A2K6R403
names: Subcellular Location Annotation
messages: Cell membrane

61622:ADGRF5
gene id: 61622:ADGRF5
uniprot id: A0A2K6RDM7
uniprot id: A0A2K6RDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

61622:TFR2
gene id: 61622:TFR2
uniprot id: A0A2K6N6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61622:LOC104674965
gene id: 61622:LOC104674965
uniprot id: A0A2K6QD00
names: Similarity
messages: Belongs to the PRAME family.

61622:CSRNP1
gene id: 61622:CSRNP1
uniprot id: A0A2K6NA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

61622:RORC
gene id: 61622:RORC
uniprot id: A0A2K6R0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:ABCA9
gene id: 61622:ABCA9
uniprot id: A0A2K6NLI7
names: Subcellular Location Annotation
messages: Membrane

61622:PLAC8
gene id: 61622:PLAC8
uniprot id: A0A2K6RMH2
names: Similarity
messages: Belongs to the cornifelin family.

61622:SRD5A2
gene id: 61622:SRD5A2
uniprot id: A0A2K6RXA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

61622:NAPEPLD
gene id: 61622:NAPEPLD
uniprot id: A0A2K6RW25
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

61622:MDM4
gene id: 61622:MDM4
uniprot id: A0A2K6NTM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

61622:CACNB4
gene id: 61622:CACNB4
uniprot id: A0A2K6RLW4
uniprot id: A0A2K6RLX0
uniprot id: A0A2K6RLX1
uniprot id: A0A2K6RLX3
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

61622:SDHB
gene id: 61622:SDHB
uniprot id: A0A2K6R6N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

61622:SUSD5
gene id: 61622:SUSD5
uniprot id: A0A2K6Q9H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PHLDA3
gene id: 61622:PHLDA3
uniprot id: A0A2K6NMW0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ME1
gene id: 61622:ME1
uniprot id: A0A2K6PP47
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

61622:CDKN1B
gene id: 61622:CDKN1B
uniprot id: A0A2K6QDA9
names: Similarity
messages: Belongs to the CDI family.

61622:LOC104680419
gene id: 61622:LOC104680419
uniprot id: A0A2K6NPD4
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61622:LCN15
gene id: 61622:LCN15
uniprot id: A0A2K6PWL2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:PLN
gene id: 61622:PLN
uniprot id: A0A2K6NPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

61622:COL4A6
gene id: 61622:COL4A6
uniprot id: A0A2K6RKZ6
uniprot id: A0A2K6RKZ8
uniprot id: A0A2K6RL03
uniprot id: A0A2K6RL05
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:GNA14
gene id: 61622:GNA14
uniprot id: A0A2K6QD59
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61622:SFXN3
gene id: 61622:SFXN3
uniprot id: A0A2K6RAT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

61622:NIPA2
gene id: 61622:NIPA2
uniprot id: A0A2K6QP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61622:MEGF6
gene id: 61622:MEGF6
uniprot id: A0A2K6N875
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:INKA1
gene id: 61622:INKA1
uniprot id: A0A2K6PL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

61622:SLC25A38
gene id: 61622:SLC25A38
uniprot id: A0A2K6RT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

61622:NAGA
gene id: 61622:NAGA
uniprot id: A0A2K6NBU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

61622:ABLIM2
gene id: 61622:ABLIM2
uniprot id: A0A2K6QN13
uniprot id: A0A2K6QN37
uniprot id: A0A2K6QN49
names: Subcellular Location Annotation
messages: Cytoplasm

61622:IL1RN
gene id: 61622:IL1RN
uniprot id: A0A2K6R303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:IRAK1BP1
gene id: 61622:IRAK1BP1
uniprot id: A0A2K6PTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

61622:MAP2K1
gene id: 61622:MAP2K1
uniprot id: A0A2K6PWS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:EXOC4
gene id: 61622:EXOC4
uniprot id: A0A2K6NLF9
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:TOLLIP
gene id: 61622:TOLLIP
uniprot id: A0A2K6R0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

61622:SAA4
gene id: 61622:SAA4
uniprot id: A0A2K6R5W5
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61622:SLC52A2
gene id: 61622:SLC52A2
uniprot id: A0A2K6PNE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

61622:TADA2B
gene id: 61622:TADA2B
uniprot id: A0A2K6NXW1
names: Subcellular Location Annotation
messages: Nucleus

61622:GOT2
gene id: 61622:GOT2
uniprot id: A0A2K6QYT8
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

61622:SULT1E1
gene id: 61622:SULT1E1
uniprot id: A0A2K6RTK2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:LOC104668317
gene id: 61622:LOC104668317
uniprot id: A0A2K6PC74
names: Similarity
messages: Belongs to the FAM90 family.

61622:KEG34 p12
gene id: 61622:KEG34_p12
uniprot id: Q15GP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

61622:OTX1
gene id: 61622:OTX1
uniprot id: A0A2K6QK07
names: Subcellular Location Annotation
messages: Nucleus

61622:ACO1
gene id: 61622:ACO1
uniprot id: A0A2K6RC94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

61622:ST3GAL6
gene id: 61622:ST3GAL6
uniprot id: A0A2K6QRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:TOE1
gene id: 61622:TOE1
uniprot id: A0A2K6NR75
names: Similarity
messages: Belongs to the CAF1 family.

61622:LANCL2
gene id: 61622:LANCL2
uniprot id: A0A2K6Q9N3
names: Similarity
messages: Belongs to the LanC-like protein family.

61622:TRPM4
gene id: 61622:TRPM4
uniprot id: A0A2K6N887
names: Subcellular Location Annotation
messages: Membrane

61622:FRK
gene id: 61622:FRK
uniprot id: A0A2K6NE13
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:CREBBP
gene id: 61622:CREBBP
uniprot id: A0A2K6N7L0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ACP7
gene id: 61622:ACP7
uniprot id: A0A2K6QR20
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

61622:C12H19orf12
gene id: 61622:C12H19orf12
uniprot id: A0A2K6Q6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

61622:ABCC4
gene id: 61622:ABCC4
uniprot id: A0A2K6RPJ9
uniprot id: A0A2K6RPK2
names: Subcellular Location Annotation
messages: Membrane

61622:SMARCAL1
gene id: 61622:SMARCAL1
uniprot id: A0A2K6Q8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

61622:PRAMEF12
gene id: 61622:PRAMEF12
uniprot id: A0A2K6N9W6
names: Similarity
messages: Belongs to the PRAME family.

61622:JAKMIP2
gene id: 61622:JAKMIP2
uniprot id: A0A2K6PE35
uniprot id: A0A2K6PE46
uniprot id: A0A2K6PE89
names: Similarity
messages: Belongs to the JAKMIP family.

61622:RHCG
gene id: 61622:RHCG
uniprot id: A0A2K6RF66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

61622:GLIS1
gene id: 61622:GLIS1
uniprot id: A0A2K6NZJ1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

61622:TNNT2
gene id: 61622:TNNT2
uniprot id: A0A2K6NDB0
uniprot id: A0A2K6NDC4
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61622:RPS21
gene id: 61622:RPS21
uniprot id: A0A2K6QLF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

61622:MAL2
gene id: 61622:MAL2
uniprot id: A0A2K6RXW1
names: Subcellular Location Annotation
messages: Membrane

61622:GSTA4
gene id: 61622:GSTA4
uniprot id: A0A2K6P438
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61622:MRPL42
gene id: 61622:MRPL42
uniprot id: A0A2K6PTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

61622:VRTN
gene id: 61622:VRTN
uniprot id: A0A2K6NE87
names: Similarity
messages: Belongs to the vertnin family.

61622:PGAM2
gene id: 61622:PGAM2
uniprot id: A0A2K6QS81
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:DYNC1I2
gene id: 61622:DYNC1I2
uniprot id: A0A2K6R3Z9
names: Similarity
messages: Belongs to the dynein intermediate chain family.

61622:SERPIND1
gene id: 61622:SERPIND1
uniprot id: A0A2K6R200
names: Similarity
messages: Belongs to the serpin family.

61622:ESYT1
gene id: 61622:ESYT1
uniprot id: A0A2K6Q175
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PENK
gene id: 61622:PENK
uniprot id: A0A2K6NS21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

61622:PIGL
gene id: 61622:PIGL
uniprot id: A0A2K6PSB7
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

61622:KIF3A
gene id: 61622:KIF3A
uniprot id: A0A2K6PD50
uniprot id: A0A2K6PDB6
uniprot id: A0A2K6PDC0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:DDIT4L
gene id: 61622:DDIT4L
uniprot id: A0A2K6QPQ4
names: Similarity
messages: Belongs to the DDIT4 family.

61622:KMT5B
gene id: 61622:KMT5B
uniprot id: A0A2K6RX55
uniprot id: A0A2K6RX76
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:CHRNB1
gene id: 61622:CHRNB1
uniprot id: A0A2K6PYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:HRH1
gene id: 61622:HRH1
uniprot id: A0A2K6NFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GABRB3
gene id: 61622:GABRB3
uniprot id: A0A2K6PEU8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:ATP13A4
gene id: 61622:ATP13A4
uniprot id: A0A2K6PC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

61622:LOC104667954
gene id: 61622:LOC104667954
uniprot id: A0A2K6Q4J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

61622:CPSF7
gene id: 61622:CPSF7
uniprot id: A0A2K6RSL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

61622:HCK
gene id: 61622:HCK
uniprot id: A0A2K6RJP6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:TPRKB
gene id: 61622:TPRKB
uniprot id: A0A2K6Q6P3
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

61622:LMF2
gene id: 61622:LMF2
uniprot id: A0A2K6NRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

61622:HLCS
gene id: 61622:HLCS
uniprot id: A0A2K6PZ37
names: Similarity
messages: Belongs to the biotin--protein ligase family.

61622:NEU2
gene id: 61622:NEU2
uniprot id: A0A2K6Q5P1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:TAF1D
gene id: 61622:TAF1D
uniprot id: A0A2K6QB03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

61622:TRMT112
gene id: 61622:TRMT112
uniprot id: A0A2K6RNK8
names: Similarity
messages: Belongs to the TRM112 family.

61622:JAGN1
gene id: 61622:JAGN1
uniprot id: A0A2K6NAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:INSRR
gene id: 61622:INSRR
uniprot id: A0A2K6QYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

61622:FUT9
gene id: 61622:FUT9
uniprot id: A0A2K6N9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61622:TTC39A
gene id: 61622:TTC39A
uniprot id: A0A2K6Q8C9
names: Similarity
messages: Belongs to the TTC39 family.

61622:ZNF280B
gene id: 61622:ZNF280B
uniprot id: A0A2K6NHL4
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

61622:UNC13A
gene id: 61622:UNC13A
uniprot id: A0A2K6QVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

61622:MCTP1
gene id: 61622:MCTP1
uniprot id: A0A2K6PU71
uniprot id: A0A2K6PU89
names: Subcellular Location Annotation
messages: Membrane

61622:RRM1
gene id: 61622:RRM1
uniprot id: A0A2K6QHQ5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

61622:ACOT6
gene id: 61622:ACOT6
uniprot id: A0A2K6R5G4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:VPS54
gene id: 61622:VPS54
uniprot id: A0A2K6Q7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

61622:TMPRSS5
gene id: 61622:TMPRSS5
uniprot id: A0A2K6QU58
uniprot id: A0A2K6QU75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CENPQ
gene id: 61622:CENPQ
uniprot id: A0A2K6P741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

61622:CLCC1
gene id: 61622:CLCC1
uniprot id: A0A2K6PZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

61622:CCR10
gene id: 61622:CCR10
uniprot id: A0A2K6PP96
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:FLT3
gene id: 61622:FLT3
uniprot id: A0A2K6PJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

61622:EEF2KMT
gene id: 61622:EEF2KMT
uniprot id: A0A2K6QTB4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

61622:NUCB1
gene id: 61622:NUCB1
uniprot id: A0A2K6NWD7
names: Similarity
messages: Belongs to the nucleobindin family.

61622:PNP
gene id: 61622:PNP
uniprot id: A0A2K6PE21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

61622:UPP2
gene id: 61622:UPP2
uniprot id: A0A2K6PDB4
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

61622:PI4KB
gene id: 61622:PI4KB
uniprot id: A0A2K6PA23
uniprot id: A0A2K6PA28
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:PIANP
gene id: 61622:PIANP
uniprot id: A0A2K6Q088
names: Subcellular Location Annotation
messages: Membrane

61622:BVES
gene id: 61622:BVES
uniprot id: A0A2K6QQV2
names: Similarity
messages: Belongs to the popeye family.

61622:GAL3ST3
gene id: 61622:GAL3ST3
uniprot id: A0A2K6PTK9
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

61622:PEBP4
gene id: 61622:PEBP4
uniprot id: A0A2K6RVF2
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

61622:TONSL
gene id: 61622:TONSL
uniprot id: A0A2K6QC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

61622:SLC66A3
gene id: 61622:SLC66A3
uniprot id: A0A2K6QHM0
uniprot id: A0A2K6QHN6
names: Subcellular Location Annotation
messages: Membrane

61622:CRAT
gene id: 61622:CRAT
uniprot id: A0A2K6NVZ4
uniprot id: A0A2K6NVZ5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61622:MTX3
gene id: 61622:MTX3
uniprot id: A0A2K6NNL0
uniprot id: A0A2K6NNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:VIL1
gene id: 61622:VIL1
uniprot id: A0A2K6R779
names: Similarity
messages: Belongs to the villin/gelsolin family.

61622:ANKRD13C
gene id: 61622:ANKRD13C
uniprot id: A0A2K6REB4
names: Subcellular Location Annotation
messages: Membrane

61622:DDX49
gene id: 61622:DDX49
uniprot id: A0A2K6PJD3
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:EBF1
gene id: 61622:EBF1
uniprot id: A0A2K6NZE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61622:GATA4
gene id: 61622:GATA4
uniprot id: A0A2K6RLM6
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104676449
gene id: 61622:LOC104676449
uniprot id: A0A2K6NTS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61622:EIF1
gene id: 61622:EIF1
uniprot id: A0A2K6PMZ9
names: Similarity
messages: Belongs to the SUI1 family.

61622:PFKFB2
gene id: 61622:PFKFB2
uniprot id: A0A2K6QGI0
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61622:TSPAN8
gene id: 61622:TSPAN8
uniprot id: A0A2K6NCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:SLC7A11
gene id: 61622:SLC7A11
uniprot id: A0A2K6PEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

61622:CALCRL
gene id: 61622:CALCRL
uniprot id: A0A2K6RUN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

61622:MED4
gene id: 61622:MED4
uniprot id: A0A2K6NNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:ARVCF
gene id: 61622:ARVCF
uniprot id: A0A2K6R828
uniprot id: A0A2K6R839
uniprot id: A0A2K6R861
names: Similarity
messages: Belongs to the beta-catenin family.

61622:LOC104663752
gene id: 61622:LOC104663752
uniprot id: A0A2K6NFN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CA7
gene id: 61622:CA7
uniprot id: A0A2K6QWA0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:POLR2I
gene id: 61622:POLR2I
uniprot id: A0A2K6RD69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61622:PPY
gene id: 61622:PPY
uniprot id: A0A2K6PS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

61622:JPH2
gene id: 61622:JPH2
uniprot id: A0A2K6PF84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

61622:ARF4
gene id: 61622:ARF4
uniprot id: A0A2K6Q077
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61622:MRPL32
gene id: 61622:MRPL32
uniprot id: A0A2K6QDJ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

61622:SLC25A19
gene id: 61622:SLC25A19
uniprot id: A0A2K6NV61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:DCTN5
gene id: 61622:DCTN5
uniprot id: A0A2K6Q555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

61622:RIDA
gene id: 61622:RIDA
uniprot id: A0A2K6QEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

61622:B4GALT3
gene id: 61622:B4GALT3
uniprot id: A0A2K6RVT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:HTR2B
gene id: 61622:HTR2B
uniprot id: A0A2K6QRB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

61622:NR0B1
gene id: 61622:NR0B1
uniprot id: A0A2K6Q884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

61622:KATNB1
gene id: 61622:KATNB1
uniprot id: A0A2K6RDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

61622:KDM5C
gene id: 61622:KDM5C
uniprot id: A0A2K6QJ20
uniprot id: A0A2K6QJ22
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

61622:ARHGDIA
gene id: 61622:ARHGDIA
uniprot id: A0A2K6PXA7
names: Similarity
messages: Belongs to the Rho GDI family.

61622:TGFBR2
gene id: 61622:TGFBR2
uniprot id: A0A2K6NGJ2
uniprot id: A0A2K6NGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

61622:PRMT5
gene id: 61622:PRMT5
uniprot id: A0A2K6NY20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

61622:SFXN1
gene id: 61622:SFXN1
uniprot id: A0A2K6NV79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

61622:RHPN1
gene id: 61622:RHPN1
uniprot id: A0A2K6Q4J4
names: Similarity
messages: Belongs to the RHPN family.

61622:TIMM10
gene id: 61622:TIMM10
uniprot id: A0A2K6R0S0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61622:STAC
gene id: 61622:STAC
uniprot id: A0A2K6PBL4
names: Subcellular Location Annotation
messages: sarcolemma

61622:ACVR1
gene id: 61622:ACVR1
uniprot id: A0A2K6NQB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:PDHX
gene id: 61622:PDHX
uniprot id: A0A2K6RT06
uniprot id: A0A2K6RT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61622:RELT
gene id: 61622:RELT
uniprot id: A0A2K6RA73
names: Similarity
messages: Belongs to the RELT family.

61622:OPA1
gene id: 61622:OPA1
uniprot id: A0A2K6PIR7
uniprot id: A0A2K6PIT4
uniprot id: A0A2K6PIZ2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:RBFOX3
gene id: 61622:RBFOX3
uniprot id: A0A2K6N7Q9
names: Subcellular Location Annotation
messages: Nucleus

61622:CLGN
gene id: 61622:CLGN
uniprot id: A0A2K6NSB1
names: Similarity
messages: Belongs to the calreticulin family.

61622:GRK2
gene id: 61622:GRK2
uniprot id: A0A2K6PMB5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:TMEM150C
gene id: 61622:TMEM150C
uniprot id: A0A2K6R1X2
names: Subcellular Location Annotation
messages: Membrane

61622:KIF3B
gene id: 61622:KIF3B
uniprot id: A0A2K6R6W5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:FSCN2
gene id: 61622:FSCN2
uniprot id: A0A2K6PYT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:ERCC3
gene id: 61622:ERCC3
uniprot id: A0A2K6QZM8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

61622:TMEM176B
gene id: 61622:TMEM176B
uniprot id: A0A2K6R8S1
names: Similarity
messages: Belongs to the TMEM176 family.

61622:SURF4
gene id: 61622:SURF4
uniprot id: A0A2K6QG77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TOP3B
gene id: 61622:TOP3B
uniprot id: A0A2K6RCP5
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

61622:MTHFD1
gene id: 61622:MTHFD1
uniprot id: A0A2K6RTN9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

61622:PGLS
gene id: 61622:PGLS
uniprot id: A0A2K6QED3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

61622:NGRN
gene id: 61622:NGRN
uniprot id: A0A2K6NW45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

61622:GABRA2
gene id: 61622:GABRA2
uniprot id: A0A2K6RDM1
uniprot id: A0A2K6RDP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

61622:ZSCAN1
gene id: 61622:ZSCAN1
uniprot id: A0A2K6Q403
names: Subcellular Location Annotation
messages: Nucleus

61622:LRRC8B
gene id: 61622:LRRC8B
uniprot id: A0A2K6NI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

61622:PLA1A
gene id: 61622:PLA1A
uniprot id: A0A2K6Q4A6
uniprot id: A0A2K6Q4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61622:ZSCAN29
gene id: 61622:ZSCAN29
uniprot id: A0A2K6RMC4
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:OXER1
gene id: 61622:OXER1
uniprot id: A0A2K6NHF5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:STEAP3
gene id: 61622:STEAP3
uniprot id: A0A2K6NJU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

61622:GJB1
gene id: 61622:GJB1
uniprot id: A0A2K6NE00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:SSH3
gene id: 61622:SSH3
uniprot id: A0A2K6Q6U0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

61622:AHCYL1
gene id: 61622:AHCYL1
uniprot id: A0A2K6QBK6
uniprot id: A0A2K6QBL2
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61622:DIS3L
gene id: 61622:DIS3L
uniprot id: A0A2K6QJT9
uniprot id: A0A2K6QJW9
names: Similarity
messages: Belongs to the RNR ribonuclease family.

61622:XKR8
gene id: 61622:XKR8
uniprot id: A0A2K6PUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61622:ARPIN
gene id: 61622:ARPIN
uniprot id: A0A2K6RWU0
names: Similarity
messages: Belongs to the Arpin family.

61622:DLGAP1
gene id: 61622:DLGAP1
uniprot id: A0A2K6PPJ0
uniprot id: A0A2K6PPJ2
uniprot id: A0A2K6PPL0
uniprot id: A0A2K6PPL6
names: Similarity
messages: Belongs to the SAPAP family.

61622:CD5
gene id: 61622:CD5
uniprot id: A0A2K6QM46
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NT5DC3
gene id: 61622:NT5DC3
uniprot id: A0A2K6QLI4
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

61622:CCL8
gene id: 61622:CCL8
uniprot id: A0A2K6PBT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:STX17
gene id: 61622:STX17
uniprot id: A0A2K6P8H7
names: Similarity
messages: Belongs to the syntaxin family.

61622:TGIF2
gene id: 61622:TGIF2
uniprot id: A0A2K6NAW2
names: Subcellular Location Annotation
messages: Nucleus

61622:SNRPG
gene id: 61622:SNRPG
uniprot id: A0A2K6RWF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

61622:NPEPPS
gene id: 61622:NPEPPS
uniprot id: A0A2K6QD95
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:OTULIN
gene id: 61622:OTULIN
uniprot id: A0A2K6NWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

61622:CHMP4B
gene id: 61622:CHMP4B
uniprot id: A0A2K6P3B4
names: Similarity
messages: Belongs to the SNF7 family.

61622:PTGDR
gene id: 61622:PTGDR
uniprot id: A0A2K6Q8N3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:DDAH1
gene id: 61622:DDAH1
uniprot id: A0A2K6NDV0
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

61622:TIMM10B
gene id: 61622:TIMM10B
uniprot id: A0A2K6P9W1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61622:FZD5
gene id: 61622:FZD5
uniprot id: A0A2K6NFH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CDC123
gene id: 61622:CDC123
uniprot id: A0A2K6RER1
uniprot id: A0A2K6REU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

61622:POLR3D
gene id: 61622:POLR3D
uniprot id: A0A2K6QE16
names: Subcellular Location Annotation
messages: Nucleus

61622:RNASEH2B
gene id: 61622:RNASEH2B
uniprot id: A0A2K6NJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

61622:ADAM33
gene id: 61622:ADAM33
uniprot id: A0A2K6N779
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:WWOX
gene id: 61622:WWOX
uniprot id: A0A2K6NGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lysosome
messages: Mitochondrion

61622:KIF1B
gene id: 61622:KIF1B
uniprot id: A0A2K6R216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

61622:HSPB3
gene id: 61622:HSPB3
uniprot id: A0A2K6NFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61622:TCTE3
gene id: 61622:TCTE3
uniprot id: A0A2K6NM75
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:DKK4
gene id: 61622:DKK4
uniprot id: A0A2K6NIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

61622:SLCO1B1
gene id: 61622:SLCO1B1
uniprot id: A0A2K6QNX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61622:ETF1
gene id: 61622:ETF1
uniprot id: A0A2K6RGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

61622:C4H6orf58
gene id: 61622:C4H6orf58
uniprot id: A0A2K6Q8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

61622:TDP1
gene id: 61622:TDP1
uniprot id: A0A2K6P9J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

61622:PNOC
gene id: 61622:PNOC
uniprot id: A0A2K6PZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

61622:STRADA
gene id: 61622:STRADA
uniprot id: A0A2K6QLU9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

61622:GUCY1A1
gene id: 61622:GUCY1A1
uniprot id: A0A2K6NIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

61622:ITIH6
gene id: 61622:ITIH6
uniprot id: A0A2K6NTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:LOC104681721
gene id: 61622:LOC104681721
uniprot id: A0A2K6NA16
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:GPR68
gene id: 61622:GPR68
uniprot id: A0A2K6NIB5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:GFOD1
gene id: 61622:GFOD1
uniprot id: A0A2K6QYY6
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:ATG4A
gene id: 61622:ATG4A
uniprot id: A0A2K6RFB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

61622:UXT
gene id: 61622:UXT
uniprot id: A0A2K6QSX2
names: Similarity
messages: Belongs to the UXT family.

61622:TGIF1
gene id: 61622:TGIF1
uniprot id: A0A2K6Q719
names: Subcellular Location Annotation
messages: Nucleus

61622:CLIC6
gene id: 61622:CLIC6
uniprot id: A0A2K6RNL4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:NDUFV2
gene id: 61622:NDUFV2
uniprot id: A0A2K6R0F2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

61622:CXCL11
gene id: 61622:CXCL11
uniprot id: A0A2K6QVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:AKIRIN1
gene id: 61622:AKIRIN1
uniprot id: A0A2K6NI59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

61622:ATP5PO
gene id: 61622:ATP5PO
uniprot id: A0A2K6PVG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

61622:TCP11L2
gene id: 61622:TCP11L2
uniprot id: A0A2K6QE91
uniprot id: A0A2K6QEC2
names: Similarity
messages: Belongs to the TCP11 family.

61622:LOC104666883
gene id: 61622:LOC104666883
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104680296
gene id: 61622:LOC104680296
uniprot id: A0A2K6NEH1
names: Similarity
messages: Belongs to the NDK family.

61622:HDAC2
gene id: 61622:HDAC2
uniprot id: A0A2K6PMJ9
uniprot id: A0A2K6PMK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

61622:RIPOR1
gene id: 61622:RIPOR1
uniprot id: A0A2K6PBE4
names: Similarity
messages: Belongs to the RIPOR family.

61622:SPTBN1
gene id: 61622:SPTBN1
uniprot id: A0A2K6Q0J9
uniprot id: A0A2K6Q0L4
names: Similarity
messages: Belongs to the spectrin family.

61622:DTD1
gene id: 61622:DTD1
uniprot id: A0A2K6QSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

61622:LDB1
gene id: 61622:LDB1
uniprot id: A0A2K6PSQ3
names: Similarity
messages: Belongs to the LDB family.

61622:MRPS18A
gene id: 61622:MRPS18A
uniprot id: A0A2K6RA28
names: Subcellular Location Annotation
messages: Mitochondrion

61622:F12
gene id: 61622:F12
uniprot id: A0A2K6NJR8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:INTS14
gene id: 61622:INTS14
uniprot id: A0A2K6RFB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

61622:RAD54L2
gene id: 61622:RAD54L2
uniprot id: A0A2K6RA17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

61622:ADGRG3
gene id: 61622:ADGRG3
uniprot id: A0A2K6RBJ6
names: Subcellular Location Annotation
messages: Membrane

61622:STAT3
gene id: 61622:STAT3
uniprot id: A0A2K6PPE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:DCK
gene id: 61622:DCK
uniprot id: A0A2K6QUM1
names: Similarity
messages: Belongs to the DCK/DGK family.

61622:PTEN
gene id: 61622:PTEN
uniprot id: A0A2K6PC42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

61622:CLDN12
gene id: 61622:CLDN12
uniprot id: A0A2K6NR66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

61622:FGF16
gene id: 61622:FGF16
uniprot id: A0A2K6NHB2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:EXOSC3
gene id: 61622:EXOSC3
uniprot id: A0A2K6PQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

61622:SLC12A4
gene id: 61622:SLC12A4
uniprot id: A0A2K6PIS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:SERINC3
gene id: 61622:SERINC3
uniprot id: A0A2K6NEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61622:LCN12
gene id: 61622:LCN12
uniprot id: A0A2K6QM48
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:ASB12
gene id: 61622:ASB12
uniprot id: A0A2K6P726
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:HOMEZ
gene id: 61622:HOMEZ
uniprot id: A0A2K6RNM8
names: Subcellular Location Annotation
messages: Nucleus

61622:AOC1
gene id: 61622:AOC1
uniprot id: A0A2K6R9V6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

61622:SULF1
gene id: 61622:SULF1
uniprot id: A0A2K6PD61
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:FOXN4
gene id: 61622:FOXN4
uniprot id: A0A2K6PIU4
names: Subcellular Location Annotation
messages: Nucleus

61622:SIX4
gene id: 61622:SIX4
uniprot id: A0A2K6NH49
uniprot id: A0A2K6NH58
names: Subcellular Location Annotation
messages: Nucleus

61622:TRHDE
gene id: 61622:TRHDE
uniprot id: A0A2K6Q3R4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:GRK1
gene id: 61622:GRK1
uniprot id: A0A2K6PMB6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:ABCC10
gene id: 61622:ABCC10
uniprot id: A0A2K6QE51
names: Subcellular Location Annotation
messages: Membrane

61622:CRYBA2
gene id: 61622:CRYBA2
uniprot id: A0A2K6RBP2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:HEATR5A
gene id: 61622:HEATR5A
uniprot id: A0A2K6Q2T6
names: Similarity
messages: Belongs to the HEATR5 family.

61622:RRM2
gene id: 61622:RRM2
uniprot id: A0A2K6R3U1
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

61622:DDX46
gene id: 61622:DDX46
uniprot id: A0A2K6P0T2
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

61622:LGMN
gene id: 61622:LGMN
uniprot id: A0A2K6RQI2
names: Similarity
messages: Belongs to the peptidase C13 family.

61622:PSMD2
gene id: 61622:PSMD2
uniprot id: A0A2K6RQN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

61622:CAPN5
gene id: 61622:CAPN5
uniprot id: A0A2K6QZI1
names: Similarity
messages: Belongs to the peptidase C2 family.

61622:CLTB
gene id: 61622:CLTB
uniprot id: A0A2K6R5R2
uniprot id: A0A2K6R5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

61622:DUPD1
gene id: 61622:DUPD1
uniprot id: A0A2K6NM47
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61622:HSPB1
gene id: 61622:HSPB1
uniprot id: A0A2K6QTT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

61622:ZNF232
gene id: 61622:ZNF232
uniprot id: A0A2K6NQL7
names: Subcellular Location Annotation
messages: Nucleus

61622:DSC3
gene id: 61622:DSC3
uniprot id: A0A2K6PU70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:TRAPPC3
gene id: 61622:TRAPPC3
uniprot id: A0A2K6PWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

61622:UHRF1
gene id: 61622:UHRF1
uniprot id: A0A2K6RWL3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

61622:PHKA2
gene id: 61622:PHKA2
uniprot id: A0A2K6P7D4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

61622:GNPAT
gene id: 61622:GNPAT
uniprot id: A0A2K6P7W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

61622:NOSIP
gene id: 61622:NOSIP
uniprot id: A0A2K6P7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

61622:LOC104672776
gene id: 61622:LOC104672776
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:DDX6
gene id: 61622:DDX6
uniprot id: A0A2K6PJH2
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:BYSL
gene id: 61622:BYSL
uniprot id: A0A2K6NCE6
names: Similarity
messages: Belongs to the bystin family.

61622:DYNLL1
gene id: 61622:DYNLL1
uniprot id: A0A2K6N9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

61622:ADGRG1
gene id: 61622:ADGRG1
uniprot id: A0A2K6RWF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

61622:CRELD2
gene id: 61622:CRELD2
uniprot id: A0A2K6PHE0
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CDCA7L
gene id: 61622:CDCA7L
uniprot id: A0A2K6QKR2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:DPYS
gene id: 61622:DPYS
uniprot id: A0A2K6P7Y8
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

61622:PDZK1IP1
gene id: 61622:PDZK1IP1
uniprot id: A0A2K6PQY1
names: Subcellular Location Annotation
messages: Membrane

61622:RSL24D1
gene id: 61622:RSL24D1
uniprot id: A0A2K6R6X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61622:RRP15
gene id: 61622:RRP15
uniprot id: A0A2K6RH20
names: Similarity
messages: Belongs to the RRP15 family.

61622:NADK2
gene id: 61622:NADK2
uniprot id: A0A2K6NTZ9
uniprot id: A0A2K6NU10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

61622:PAQR4
gene id: 61622:PAQR4
uniprot id: A0A2K6R5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:AADACL2
gene id: 61622:AADACL2
uniprot id: A0A2K6PN49
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61622:COL4A1
gene id: 61622:COL4A1
uniprot id: A0A2K6NU22
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:SI
gene id: 61622:SI
uniprot id: A0A2K6RK08
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:APEX2
gene id: 61622:APEX2
uniprot id: A0A2K6PKM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

61622:NSDHL
gene id: 61622:NSDHL
uniprot id: A0A2K6P9F9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61622:IRF8
gene id: 61622:IRF8
uniprot id: A0A2K6R0H5
names: Subcellular Location Annotation
messages: Nucleus

61622:HMBOX1
gene id: 61622:HMBOX1
uniprot id: A0A2K6PG00
names: Subcellular Location Annotation
messages: Nucleus

61622:TNKS
gene id: 61622:TNKS
uniprot id: A0A2K6NKJ2
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:RBM46
gene id: 61622:RBM46
uniprot id: A0A2K6RMJ8
uniprot id: A0A2K6RMK8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PNPLA7
gene id: 61622:PNPLA7
uniprot id: A0A2K6RHN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LCN8
gene id: 61622:LCN8
uniprot id: A0A2K6NL32
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:NDUFB9
gene id: 61622:NDUFB9
uniprot id: A0A2K6PV72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:NIFK
gene id: 61622:NIFK
uniprot id: A0A2K6QS39
names: Subcellular Location Annotation
messages: nucleolus

61622:NR2F2
gene id: 61622:NR2F2
uniprot id: A0A2K6RWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:HAMP
gene id: 61622:HAMP
uniprot id: A0A2K6RNE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

61622:SYNCRIP
gene id: 61622:SYNCRIP
uniprot id: A0A2K6N940
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PDCD11
gene id: 61622:PDCD11
uniprot id: A0A2K6P751
names: Subcellular Location Annotation
messages: nucleolus

61622:INTS7
gene id: 61622:INTS7
uniprot id: A0A2K6QQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

61622:SNRPA1
gene id: 61622:SNRPA1
uniprot id: A0A2K6QL88
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

61622:SYNJ2
gene id: 61622:SYNJ2
uniprot id: A0A2K6NTN4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

61622:ATP5MC3
gene id: 61622:ATP5MC3
uniprot id: A0A2K6R5Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

61622:FGF23
gene id: 61622:FGF23
uniprot id: A0A2K6QQ06
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:NAB2
gene id: 61622:NAB2
uniprot id: A0A2K6R0L5
uniprot id: A0A2K6R0L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

61622:INPPL1
gene id: 61622:INPPL1
uniprot id: A0A2K6P7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium
messages: spindle pole

61622:LOC104663575
gene id: 61622:LOC104663575
uniprot id: A0A2K6NJG1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:UBAP2L
gene id: 61622:UBAP2L
uniprot id: A0A2K6Q2L5
uniprot id: A0A2K6Q2N0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:KDM3A
gene id: 61622:KDM3A
uniprot id: A0A2K6R4H0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

61622:COG4
gene id: 61622:COG4
uniprot id: A0A2K6QX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

61622:SUPV3L1
gene id: 61622:SUPV3L1
uniprot id: A0A2K6N7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

61622:IRAK4
gene id: 61622:IRAK4
uniprot id: A0A2K6QAA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

61622:PAQR8
gene id: 61622:PAQR8
uniprot id: A0A2K6NBJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:ST3GAL3
gene id: 61622:ST3GAL3
uniprot id: A0A2K6R9U1
uniprot id: A0A2K6R9X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:KDM6A
gene id: 61622:KDM6A
uniprot id: A0A2K6P9W8
uniprot id: A0A2K6P9Y7
uniprot id: A0A2K6P9Y9
uniprot id: A0A2K6P9Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

61622:DDX24
gene id: 61622:DDX24
uniprot id: A0A2K6NNT5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

61622:HS3ST3B1
gene id: 61622:HS3ST3B1
uniprot id: A0A2K6NI91
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:ALKAL1
gene id: 61622:ALKAL1
uniprot id: A0A2K6QV79
uniprot id: A0A2K6QVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

61622:POLL
gene id: 61622:POLL
uniprot id: A0A2K6PKL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

61622:CPNE3
gene id: 61622:CPNE3
uniprot id: A0A2K6NZ56
names: Similarity
messages: Belongs to the copine family.

61622:CDK8
gene id: 61622:CDK8
uniprot id: A0A2K6R7R9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MS4A7
gene id: 61622:MS4A7
uniprot id: A0A2K6P136
names: Similarity
messages: Belongs to the MS4A family.

61622:LOC104675111
gene id: 61622:LOC104675111
uniprot id: A0A2K6PPU2
uniprot id: A0A2K6R3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:SPG7
gene id: 61622:SPG7
uniprot id: A0A2K6RX13
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

61622:EVA1A
gene id: 61622:EVA1A
uniprot id: A0A2K6QGX9
names: Similarity
messages: Belongs to the EVA1 family.

61622:HAX1
gene id: 61622:HAX1
uniprot id: A0A2K6RQF3
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

61622:EYA1
gene id: 61622:EYA1
uniprot id: A0A2K6R451
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

61622:PCSK2
gene id: 61622:PCSK2
uniprot id: A0A2K6NTR6
uniprot id: A0A2K6NTS8
names: Similarity
messages: Belongs to the peptidase S8 family.

61622:DDX58
gene id: 61622:DDX58
uniprot id: A0A2K6P0Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

61622:E2F4
gene id: 61622:E2F4
uniprot id: A0A2K6Q4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:TM4SF18
gene id: 61622:TM4SF18
uniprot id: A0A2K6P115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:CCNT1
gene id: 61622:CCNT1
uniprot id: A0A2K6RNZ2
names: Similarity
messages: Belongs to the cyclin family.

61622:LOC104674497
gene id: 61622:LOC104674497
uniprot id: A0A2K6Q483
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61622:LOC104668918
gene id: 61622:LOC104668918
uniprot id: A0A2K6Q698
names: Similarity
messages: Belongs to the PRAME family.

61622:WNK1
gene id: 61622:WNK1
uniprot id: A0A2K6QPI9
uniprot id: A0A2K6QPK1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

61622:GPATCH11
gene id: 61622:GPATCH11
uniprot id: A0A2K6QR71
uniprot id: A0A2K6QR78
names: Similarity
messages: Belongs to the GPATCH11 family.

61622:CEBPG
gene id: 61622:CEBPG
uniprot id: A0A2K6NM55
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

61622:PFN4
gene id: 61622:PFN4
uniprot id: A0A2K6R730
names: Similarity
messages: Belongs to the profilin family.

61622:NPR2
gene id: 61622:NPR2
uniprot id: A0A2K6Q6M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

61622:LOC104680184
gene id: 61622:LOC104680184
uniprot id: A0A2K6NSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

61622:DDX18
gene id: 61622:DDX18
uniprot id: A0A2K6NC17
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

61622:LOC104667500
gene id: 61622:LOC104667500
uniprot id: A0A2K6NCL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:HPGD
gene id: 61622:HPGD
uniprot id: A0A2K6NKM1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:MAN1A1
gene id: 61622:MAN1A1
uniprot id: A0A2K6P217
uniprot id: A0A2K6P222
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:LOC104654235
gene id: 61622:LOC104654235
uniprot id: A0A2K6NXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

61622:SOAT2
gene id: 61622:SOAT2
uniprot id: A0A2K6RGJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ICAM1
gene id: 61622:ICAM1
uniprot id: A0A2K6PK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:UBE2E3
gene id: 61622:UBE2E3
uniprot id: A0A2K6QTM7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:IRF6
gene id: 61622:IRF6
uniprot id: A0A2K6PPD6
names: Subcellular Location Annotation
messages: Nucleus

61622:PGM2
gene id: 61622:PGM2
uniprot id: A0A2K6R7X7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61622:HOXA7
gene id: 61622:HOXA7
uniprot id: A0A2K6PE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:SMG5
gene id: 61622:SMG5
uniprot id: A0A2K6P4C4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

61622:ZSCAN4
gene id: 61622:ZSCAN4
uniprot id: A0A2K6P7U3
names: Subcellular Location Annotation
messages: Nucleus

61622:PCMTD2
gene id: 61622:PCMTD2
uniprot id: A0A2K6R8F6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:GJB5
gene id: 61622:GJB5
uniprot id: A0A2K6NHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:FGF18
gene id: 61622:FGF18
uniprot id: A0A2K6RM39
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:FSCN1
gene id: 61622:FSCN1
uniprot id: A0A2K6PJ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:CDK20
gene id: 61622:CDK20
uniprot id: A0A2K6NYZ2
uniprot id: A0A2K6NYZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

61622:TMEM63B
gene id: 61622:TMEM63B
uniprot id: A0A2K6PPT3
uniprot id: A0A2K6PPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

61622:ARRDC4
gene id: 61622:ARRDC4
uniprot id: A0A2K6NFM3
names: Similarity
messages: Belongs to the arrestin family.

61622:FXR1
gene id: 61622:FXR1
uniprot id: A0A2K6PXZ1
uniprot id: A0A2K6PXZ2
uniprot id: A0A2K6PY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Nucleus envelope
messages: Postsynapse
messages: Synapse
messages: dendritic spine

61622:ANK1
gene id: 61622:ANK1
uniprot id: A0A2K6NSS8
uniprot id: A0A2K6NSV3
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:NUS1
gene id: 61622:NUS1
uniprot id: A0A2K6PXT8
names: Similarity
messages: Belongs to the UPP synthase family.

61622:FAR2
gene id: 61622:FAR2
uniprot id: A0A2K6RDC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

61622:PRM1
gene id: 61622:PRM1
uniprot id: A0A2K6PXN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

61622:IHH
gene id: 61622:IHH
uniprot id: A0A2K6RHE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

61622:KCNK5
gene id: 61622:KCNK5
uniprot id: A0A2K6NI31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:INSIG1
gene id: 61622:INSIG1
uniprot id: A0A2K6PLY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

61622:GIP
gene id: 61622:GIP
uniprot id: A0A2K6P2Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

61622:LOC104667762
gene id: 61622:LOC104667762
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:LSM1
gene id: 61622:LSM1
uniprot id: A0A2K6Q6Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

61622:NXPE2
gene id: 61622:NXPE2
uniprot id: A0A2K6R035
names: Similarity
messages: Belongs to the NXPE family.

61622:CCND2
gene id: 61622:CCND2
uniprot id: A0A2K6Q182
names: Similarity
messages: Belongs to the cyclin family.

61622:ABITRAM
gene id: 61622:ABITRAM
uniprot id: A0A2K6RE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

61622:LOC104668174
gene id: 61622:LOC104668174
uniprot id: A0A2K6RQ54
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:COG7
gene id: 61622:COG7
uniprot id: A0A2K6R5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:ITGAM
gene id: 61622:ITGAM
uniprot id: A0A2K6NUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:NRP2
gene id: 61622:NRP2
uniprot id: A0A2K6R130
uniprot id: A0A2K6R138
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TNFAIP6
gene id: 61622:TNFAIP6
uniprot id: A0A2K6R1U2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:C20H16orf91
gene id: 61622:C20H16orf91
uniprot id: A0A2K6R6M9
names: Similarity
messages: Belongs to the UQCC4 family.

61622:SYT1
gene id: 61622:SYT1
uniprot id: A0A2K6P3M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

61622:DLL3
gene id: 61622:DLL3
uniprot id: A0A2K6Q9H0
uniprot id: A0A2K6Q9I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GFAP
gene id: 61622:GFAP
uniprot id: A0A2K6PZ80
uniprot id: A0A2K6PZA6
names: Similarity
messages: Belongs to the intermediate filament family.

61622:UBA7
gene id: 61622:UBA7
uniprot id: A0A2K6NZI2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61622:GINS3
gene id: 61622:GINS3
uniprot id: A0A2K6QE28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

61622:CD79B
gene id: 61622:CD79B
uniprot id: A0A2K6PPC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:STEAP4
gene id: 61622:STEAP4
uniprot id: A0A2K6NKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

61622:ATP6V0B
gene id: 61622:ATP6V0B
uniprot id: A0A2K6Q645
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

61622:GAS6
gene id: 61622:GAS6
uniprot id: A0A2K6QVJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SCARB1
gene id: 61622:SCARB1
uniprot id: A0A2K6PV33
uniprot id: A0A2K6PV40
names: Similarity
messages: Belongs to the CD36 family.

61622:ZNF500
gene id: 61622:ZNF500
uniprot id: A0A2K6P5C1
names: Subcellular Location Annotation
messages: Nucleus

61622:PARP10
gene id: 61622:PARP10
uniprot id: A0A2K6QPL9
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:KRT71
gene id: 61622:KRT71
uniprot id: A0A2K6Q6Z9
names: Similarity
messages: Belongs to the intermediate filament family.

61622:INS
gene id: 61622:INS
uniprot id: A0A2K6R041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

61622:IL3RA
gene id: 61622:IL3RA
uniprot id: A0A2K6Q0W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

61622:FAM91A1
gene id: 61622:FAM91A1
uniprot id: A0A2K6QLU2
names: Similarity
messages: Belongs to the FAM91 family.

61622:PACSIN1
gene id: 61622:PACSIN1
uniprot id: A0A2K6RMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

61622:LOC104662927
gene id: 61622:LOC104662927
uniprot id: A0A2K6PUZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

61622:CCDC90B
gene id: 61622:CCDC90B
uniprot id: A0A2K6R9F9
names: Similarity
messages: Belongs to the CCDC90 family.

61622:CADM3
gene id: 61622:CADM3
uniprot id: A0A2K6QL41
uniprot id: A0A2K6QL53
names: Similarity
messages: Belongs to the nectin family.

61622:HOXD4
gene id: 61622:HOXD4
uniprot id: A0A2K6NRK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:LOC104677678
gene id: 61622:LOC104677678
uniprot id: A0A2K6NBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:TM6SF2
gene id: 61622:TM6SF2
uniprot id: A0A2K6QAR6
uniprot id: A0A2K6QAT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

61622:GLA
gene id: 61622:GLA
uniprot id: A0A2K6QEG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

61622:FAM72A
gene id: 61622:FAM72A
uniprot id: A0A2K6PS91
names: Similarity
messages: Belongs to the FAM72 family.

61622:UBE2L6
gene id: 61622:UBE2L6
uniprot id: A0A2K6NYB6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:MBP
gene id: 61622:MBP
uniprot id: A0A2K6NUI0
uniprot id: A0A2K6NUJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

61622:MOCS3
gene id: 61622:MOCS3
uniprot id: A0A2K6NBN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

61622:SLC7A7
gene id: 61622:SLC7A7
uniprot id: A0A2K6QAC3
names: Subcellular Location Annotation
messages: Membrane

61622:SAMHD1
gene id: 61622:SAMHD1
uniprot id: A0A2K6PXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

61622:DEFB119
gene id: 61622:DEFB119
uniprot id: A0A2K6RLY7
uniprot id: A0A2K6RLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:TFAP2D
gene id: 61622:TFAP2D
uniprot id: A0A2K6RHS6
names: Similarity
messages: Belongs to the AP-2 family.

61622:CASP2
gene id: 61622:CASP2
uniprot id: A0A2K6P664
uniprot id: A0A2K6P674
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:KAT8
gene id: 61622:KAT8
uniprot id: A0A2K6QLK1
uniprot id: A0A2K6QLK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

61622:RABGGTB
gene id: 61622:RABGGTB
uniprot id: A0A2K6RE21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

61622:VPS13B
gene id: 61622:VPS13B
uniprot id: A0A2K6QGQ5
uniprot id: A0A2K6QGR4
names: Similarity
messages: Belongs to the VPS13 family.

61622:GALR2
gene id: 61622:GALR2
uniprot id: A0A2K6RKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:FIS1
gene id: 61622:FIS1
uniprot id: A0A2K6NLG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

61622:GSS
gene id: 61622:GSS
uniprot id: A0A2K6NTG2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

61622:GDPD2
gene id: 61622:GDPD2
uniprot id: A0A2K6PVQ9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:OGDHL
gene id: 61622:OGDHL
uniprot id: A0A2K6Q2S5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

61622:SEPTIN9
gene id: 61622:SEPTIN9
uniprot id: A0A2K6R1L3
uniprot id: A0A2K6R1N3
uniprot id: A0A2K6R1R7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

61622:MYF5
gene id: 61622:MYF5
uniprot id: A0A2K6R007
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

61622:NCOR1
gene id: 61622:NCOR1
uniprot id: A0A2K6QT44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-CoR nuclear receptor corepressors family.
messages: Nucleus

61622:EIF5A
gene id: 61622:EIF5A
uniprot id: A0A2K6QYK5
uniprot id: A0A2K6QYN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

61622:RNF114
gene id: 61622:RNF114
uniprot id: A0A2K6QKS1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

61622:CNTN2
gene id: 61622:CNTN2
uniprot id: A0A2K6Q2H3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

61622:ITPR2
gene id: 61622:ITPR2
uniprot id: A0A2K6Q332
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

61622:FOXH1
gene id: 61622:FOXH1
uniprot id: A0A2K6QPZ2
names: Subcellular Location Annotation
messages: Nucleus

61622:RPL14
gene id: 61622:RPL14
uniprot id: A0A2K6R961
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

61622:MRPS30
gene id: 61622:MRPS30
uniprot id: A0A2K6PS38
names: Subcellular Location Annotation
messages: Mitochondrion

61622:PHB
gene id: 61622:PHB
uniprot id: A0A2K6QMK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

61622:MRPL27
gene id: 61622:MRPL27
uniprot id: A0A2K6P9A1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

61622:VPS26C
gene id: 61622:VPS26C
uniprot id: A0A2K6QSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

61622:BEX4
gene id: 61622:BEX4
uniprot id: A0A2K6QFR3
names: Similarity
messages: Belongs to the BEX family.

61622:CTSE
gene id: 61622:CTSE
uniprot id: A0A2K6RLQ4
uniprot id: A0A2K6RLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

61622:DHDH
gene id: 61622:DHDH
uniprot id: A0A2K6RDF1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:SLC41A1
gene id: 61622:SLC41A1
uniprot id: A0A2K6NV65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

61622:RAB39B
gene id: 61622:RAB39B
uniprot id: A0A2K6N7B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

61622:ZFHX2
gene id: 61622:ZFHX2
uniprot id: A0A2K6Q256
names: Subcellular Location Annotation
messages: Nucleus

61622:RUVBL1
gene id: 61622:RUVBL1
uniprot id: A0A2K6QEF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

61622:PSMD3
gene id: 61622:PSMD3
uniprot id: A0A2K6Q3H8
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

61622:LIPH
gene id: 61622:LIPH
uniprot id: A0A2K6RSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61622:PYCR3
gene id: 61622:PYCR3
uniprot id: A0A2K6PWA0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61622:TGM2
gene id: 61622:TGM2
uniprot id: A0A2K6Q284
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:LAMB1
gene id: 61622:LAMB1
uniprot id: A0A2K6QSI4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61622:ARPC4
gene id: 61622:ARPC4
uniprot id: A0A2K6QVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

61622:SERBP1
gene id: 61622:SERBP1
uniprot id: A0A2K6R260
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

61622:TCL1A
gene id: 61622:TCL1A
uniprot id: A0A2K6N958
names: Similarity
messages: Belongs to the TCL1 family.

61622:OLFM3
gene id: 61622:OLFM3
uniprot id: A0A2K6QU11
uniprot id: A0A2K6QU42
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:PPM1G
gene id: 61622:PPM1G
uniprot id: A0A2K6R3Z8
names: Similarity
messages: Belongs to the PP2C family.

61622:SLC45A3
gene id: 61622:SLC45A3
uniprot id: A0A2K6NNK9
names: Subcellular Location Annotation
messages: Membrane

61622:RHBDF2
gene id: 61622:RHBDF2
uniprot id: A0A2K6R0U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

61622:PPP3CB
gene id: 61622:PPP3CB
uniprot id: A0A2K6PI52
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

61622:KHDC1
gene id: 61622:KHDC1
uniprot id: A0A2K6Q482
names: Similarity
messages: Belongs to the KHDC1 family.

61622:UTP15
gene id: 61622:UTP15
uniprot id: A0A2K6PX25
names: Subcellular Location Annotation
messages: nucleolus

61622:MDM1
gene id: 61622:MDM1
uniprot id: A0A2K6PFB6
uniprot id: A0A2K6PFH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

61622:DLX5
gene id: 61622:DLX5
uniprot id: A0A2K6PIM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

61622:MRPL11
gene id: 61622:MRPL11
uniprot id: A0A2K6R1U4
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

61622:ELK4
gene id: 61622:ELK4
uniprot id: A0A2K6QKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:MED31
gene id: 61622:MED31
uniprot id: A0A2K6PZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61622:LOC104680944
gene id: 61622:LOC104680944
uniprot id: A0A2K6NHP6
names: Subcellular Location Annotation
messages: Nucleus

61622:KPNA5
gene id: 61622:KPNA5
uniprot id: A0A2K6NC93
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:LOC104670975
gene id: 61622:LOC104670975
uniprot id: A0A2K6Q432
names: Subcellular Location Annotation
messages: Nucleus

61622:SAP18
gene id: 61622:SAP18
uniprot id: A0A2K6P401
names: Similarity
messages: Belongs to the SAP18 family.

61622:MCCC2
gene id: 61622:MCCC2
uniprot id: A0A2K6QFL4
names: Similarity
messages: Belongs to the AccD/PCCB family.

61622:MPDZ
gene id: 61622:MPDZ
uniprot id: A0A2K6P2Z6
names: Subcellular Location Annotation
messages: tight junction

61622:IRAK2
gene id: 61622:IRAK2
uniprot id: A0A2K6N8S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

61622:EIF2A
gene id: 61622:EIF2A
uniprot id: A0A2K6QR05
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

61622:SLC22A1
gene id: 61622:SLC22A1
uniprot id: A0A2K6PXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

61622:PRSS12
gene id: 61622:PRSS12
uniprot id: A0A2K6PP32
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

61622:OS9
gene id: 61622:OS9
uniprot id: A0A2K6NGB8
uniprot id: A0A2K6NGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

61622:MS4A5
gene id: 61622:MS4A5
uniprot id: A0A2K6QI89
names: Similarity
messages: Belongs to the MS4A family.

61622:ZW10
gene id: 61622:ZW10
uniprot id: A0A2K6PF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

61622:FARSB
gene id: 61622:FARSB
uniprot id: A0A2K6P078
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

61622:IL17RD
gene id: 61622:IL17RD
uniprot id: A0A2K6NNH2
names: Subcellular Location Annotation
messages: Membrane

61622:MOB1A
gene id: 61622:MOB1A
uniprot id: A0A2K6QK69
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:MCM6
gene id: 61622:MCM6
uniprot id: A0A2K6QLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61622:PRDX2
gene id: 61622:PRDX2
uniprot id: A0A2K6Q0K4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61622:LOC104680519
gene id: 61622:LOC104680519
uniprot id: A0A2K6NGI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

61622:TUBGCP2
gene id: 61622:TUBGCP2
uniprot id: A0A2K6N706
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61622:LOC104676736
gene id: 61622:LOC104676736
uniprot id: A0A2K6NLK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

61622:MOB1B
gene id: 61622:MOB1B
uniprot id: A0A2K6NCH6
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:ATAD2
gene id: 61622:ATAD2
uniprot id: A0A2K6NWC8
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:ST13
gene id: 61622:ST13
uniprot id: A0A2K6PPW1
names: Similarity
messages: Belongs to the FAM10 family.

61622:LOC104659826
gene id: 61622:LOC104659826
uniprot id: A0A2K6Q5G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SLC25A16
gene id: 61622:SLC25A16
uniprot id: A0A2K6P1N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:PPP1CB
gene id: 61622:PPP1CB
uniprot id: A0A2K6QEJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

61622:MFAP1
gene id: 61622:MFAP1
uniprot id: A0A2K6QL46
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

61622:KIF21B
gene id: 61622:KIF21B
uniprot id: A0A2K6Q3B1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:SYPL2
gene id: 61622:SYPL2
uniprot id: A0A2K6RS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61622:HTRA3
gene id: 61622:HTRA3
uniprot id: A0A2K6RJ17
uniprot id: A0A2K6RJ23
names: Similarity
messages: Belongs to the peptidase S1C family.

61622:LAMTOR2
gene id: 61622:LAMTOR2
uniprot id: A0A2K6RUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

61622:TMEM126B
gene id: 61622:TMEM126B
uniprot id: A0A2K6NI44
names: Subcellular Location Annotation
messages: Membrane

61622:GALNT12
gene id: 61622:GALNT12
uniprot id: A0A2K6NXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:AIF1
gene id: 61622:AIF1
uniprot id: A0A2K6PI50
names: Subcellular Location Annotation
messages: ruffle membrane

61622:PHAX
gene id: 61622:PHAX
uniprot id: A0A2K6NJY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

61622:A2ML1
gene id: 61622:A2ML1
uniprot id: A0A2K6QBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

61622:CLK1
gene id: 61622:CLK1
uniprot id: A0A2K6Q239
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:EBF2
gene id: 61622:EBF2
uniprot id: A0A2K6PZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61622:TK1
gene id: 61622:TK1
uniprot id: A0A2K6P990
names: Similarity
messages: Belongs to the thymidine kinase family.

61622:DPH2
gene id: 61622:DPH2
uniprot id: A0A2K6RSV4
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

61622:LOC104679834
gene id: 61622:LOC104679834
uniprot id: A0A2K6QGT6
names: Subunit
messages: Monomer.

61622:GRHL2
gene id: 61622:GRHL2
uniprot id: A0A2K6NCG8
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104664030
gene id: 61622:LOC104664030
uniprot id: A0A2K6R0X1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:CHRDL2
gene id: 61622:CHRDL2
uniprot id: A0A2K6P0B6
names: Subcellular Location Annotation
messages: Secreted

61622:TENT5C
gene id: 61622:TENT5C
uniprot id: A0A2K6N902
names: Similarity
messages: Belongs to the TENT family.

61622:IDO2
gene id: 61622:IDO2
uniprot id: A0A2K6QAD5
uniprot id: A0A2K6QAD7
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

61622:MRPL15
gene id: 61622:MRPL15
uniprot id: A0A2K6QD89
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

61622:NDRG2
gene id: 61622:NDRG2
uniprot id: A0A2K6PGW2
uniprot id: A0A2K6PGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

61622:ING2
gene id: 61622:ING2
uniprot id: A0A2K6PIE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:ARAP1
gene id: 61622:ARAP1
uniprot id: A0A2K6P0I9
uniprot id: A0A2K6P0J1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:NAF1
gene id: 61622:NAF1
uniprot id: A0A2K6R134
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

61622:LALBA
gene id: 61622:LALBA
uniprot id: A0A2K6P4R7
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

61622:RPL36AL
gene id: 61622:RPL36AL
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:NF2
gene id: 61622:NF2
uniprot id: A0A2K6NI47
uniprot id: A0A2K6NI50
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:PTPRN
gene id: 61622:PTPRN
uniprot id: A0A2K6QK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

61622:SLCO1C1
gene id: 61622:SLCO1C1
uniprot id: A0A2K6RUH7
uniprot id: A0A2K6RUI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SLC19A3
gene id: 61622:SLC19A3
uniprot id: A0A2K6Q3M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

61622:RNF20
gene id: 61622:RNF20
uniprot id: A0A2K6RGS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

61622:LOC104672806
gene id: 61622:LOC104672806
uniprot id: A0A2K6PVM6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:SPOCK2
gene id: 61622:SPOCK2
uniprot id: A0A2K6PNR5
uniprot id: A0A2K6PNR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104673585
gene id: 61622:LOC104673585
uniprot id: A0A2K6P9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:SLC13A1
gene id: 61622:SLC13A1
uniprot id: A0A2K6Q287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:IPO7
gene id: 61622:IPO7
uniprot id: A0A2K6PFC8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:SFR1
gene id: 61622:SFR1
uniprot id: A0A2K6NNW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

61622:UNC5B
gene id: 61622:UNC5B
uniprot id: A0A2K6P3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

61622:SLC13A2
gene id: 61622:SLC13A2
uniprot id: A0A2K6QCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:RUVBL2
gene id: 61622:RUVBL2
uniprot id: A0A2K6P5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

61622:BUD23
gene id: 61622:BUD23
uniprot id: A0A2K6RI28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

61622:PRUNE1
gene id: 61622:PRUNE1
uniprot id: A0A2K6QFN0
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

61622:HGS
gene id: 61622:HGS
uniprot id: A0A2K6R2N1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

61622:EIF1AX
gene id: 61622:EIF1AX
uniprot id: A0A2K6RBU4
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

61622:HTR1D
gene id: 61622:HTR1D
uniprot id: A0A2K6NAW6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

61622:CLPP
gene id: 61622:CLPP
uniprot id: A0A2K6R877
names: Similarity
messages: Belongs to the peptidase S14 family.

61622:CXCL10
gene id: 61622:CXCL10
uniprot id: A0A2K6NFW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:EXOG
gene id: 61622:EXOG
uniprot id: A0A2K6RTG7
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

61622:LOC104681238
gene id: 61622:LOC104681238
uniprot id: A0A2K6NN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:APLP1
gene id: 61622:APLP1
uniprot id: A0A2K6R7N5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GASK1B
gene id: 61622:GASK1B
uniprot id: A0A2K6RH53
names: Similarity
messages: Belongs to the GASK family.

61622:NDUFA11
gene id: 61622:NDUFA11
uniprot id: A0A2K6N7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:ADAM17
gene id: 61622:ADAM17
uniprot id: A0A2K6QKL3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HARS2
gene id: 61622:HARS2
uniprot id: A0A2K6Q8Y7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:NKX3-2
gene id: 61622:NKX3-2
uniprot id: A0A2K6PHV4
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104662340
gene id: 61622:LOC104662340
uniprot id: A0A2K6P3G0
names: Similarity
messages: Belongs to the globin family.

61622:AFF4
gene id: 61622:AFF4
uniprot id: A0A2K6PSY5
uniprot id: A0A2K6PSY9
names: Similarity
messages: Belongs to the AF4 family.

61622:DCTPP1
gene id: 61622:DCTPP1
uniprot id: A0A2K6QTE2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

61622:CNOT6
gene id: 61622:CNOT6
uniprot id: A0A2K6Q2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

61622:PDGFRA
gene id: 61622:PDGFRA
uniprot id: A0A2K6QIB8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

61622:PGS1
gene id: 61622:PGS1
uniprot id: A0A2K6NHE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

61622:PSMC1
gene id: 61622:PSMC1
uniprot id: A0A2K6NCQ3
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:FFAR1
gene id: 61622:FFAR1
uniprot id: A0A2K6NLT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PARK7
gene id: 61622:PARK7
uniprot id: A0A2K6RMF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

61622:MOSPD3
gene id: 61622:MOSPD3
uniprot id: A0A2K6R4X5
names: Subcellular Location Annotation
messages: Membrane

61622:ESYT3
gene id: 61622:ESYT3
uniprot id: A0A2K6R2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NFYB
gene id: 61622:NFYB
uniprot id: A0A2K6QGH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

61622:ZSCAN31
gene id: 61622:ZSCAN31
uniprot id: A0A2K6PFB8
names: Subcellular Location Annotation
messages: Nucleus

61622:CPNE4
gene id: 61622:CPNE4
uniprot id: A0A2K6RQ95
names: Similarity
messages: Belongs to the copine family.

61622:MRPL17
gene id: 61622:MRPL17
uniprot id: A0A2K6PIH1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

61622:RBM42
gene id: 61622:RBM42
uniprot id: A0A2K6RA67
uniprot id: A0A2K6RA81
names: Similarity
messages: Belongs to the RRM RBM42 family.

61622:FAM20A
gene id: 61622:FAM20A
uniprot id: A0A2K6NPK9
names: Similarity
messages: Belongs to the FAM20 family.

61622:OTUB2
gene id: 61622:OTUB2
uniprot id: A0A2K6PMQ6
names: Similarity
messages: Belongs to the peptidase C65 family.

61622:TSPAN15
gene id: 61622:TSPAN15
uniprot id: A0A2K6NJ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:EBF4
gene id: 61622:EBF4
uniprot id: A0A2K6RD10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61622:B4GALT7
gene id: 61622:B4GALT7
uniprot id: A0A2K6PN93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:TMED1
gene id: 61622:TMED1
uniprot id: A0A2K6NRG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61622:LAMP3
gene id: 61622:LAMP3
uniprot id: A0A2K6NRS0
uniprot id: A0A2K6NRS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

61622:PTCD2
gene id: 61622:PTCD2
uniprot id: A0A2K6N724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

61622:GOLPH3L
gene id: 61622:GOLPH3L
uniprot id: A0A2K6RBS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

61622:SBNO1
gene id: 61622:SBNO1
uniprot id: A0A2K6PW10
names: Similarity
messages: Belongs to the SBNO family.

61622:C14H2orf88
gene id: 61622:C14H2orf88
uniprot id: A0A2K6NQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

61622:CDK2
gene id: 61622:CDK2
uniprot id: A0A2K6P9I2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MEFV
gene id: 61622:MEFV
uniprot id: A0A2K6NCA0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:VMA21
gene id: 61622:VMA21
uniprot id: A0A2K6QGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

61622:UBE2L3
gene id: 61622:UBE2L3
uniprot id: A0A2K6NAB6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:TUBG1
gene id: 61622:TUBG1
uniprot id: A0A2K6QS78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

61622:UTP11
gene id: 61622:UTP11
uniprot id: A0A2K6NFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

61622:APOC4
gene id: 61622:APOC4
uniprot id: A0A2K6PFU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

61622:ATOH7
gene id: 61622:ATOH7
uniprot id: A0A2K6N9K3
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

61622:ASIC3
gene id: 61622:ASIC3
uniprot id: A0A2K6NDU9
uniprot id: A0A2K6NDV7
names: Subcellular Location Annotation
messages: Membrane

61622:DCTN2
gene id: 61622:DCTN2
uniprot id: A0A2K6QJQ6
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

61622:APOC3
gene id: 61622:APOC3
uniprot id: A0A2K6RCA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

61622:SLC25A11
gene id: 61622:SLC25A11
uniprot id: A0A2K6QG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:TRAPPC4
gene id: 61622:TRAPPC4
uniprot id: A0A2K6RHJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

61622:RNASE8
gene id: 61622:RNASE8
uniprot id: A0A2K6NQU9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:GPR37L1
gene id: 61622:GPR37L1
uniprot id: A0A2K6P8H3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:DNAJC22
gene id: 61622:DNAJC22
uniprot id: A0A2K6R7T7
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

61622:CDK5RAP1
gene id: 61622:CDK5RAP1
uniprot id: A0A2K6QFD7
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

61622:TXNL4A
gene id: 61622:TXNL4A
uniprot id: A0A2K6PYL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

61622:PRMT3
gene id: 61622:PRMT3
uniprot id: A0A2K6P371
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LOC104671094
gene id: 61622:LOC104671094
uniprot id: A0A2K6PPY6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

61622:PI4K2B
gene id: 61622:PI4K2B
uniprot id: A0A2K6NXM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

61622:RAD9A
gene id: 61622:RAD9A
uniprot id: A0A2K6Q1U6
names: Similarity
messages: Belongs to the rad9 family.

61622:TRIM5
gene id: 61622:TRIM5
uniprot id: A0A2K6QBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

61622:RNF5
gene id: 61622:RNF5
uniprot id: A0A2K6QN74
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

61622:SGCE
gene id: 61622:SGCE
uniprot id: A0A2K6NB59
uniprot id: A0A2K6NB71
uniprot id: A0A2K6NB84
uniprot id: A0A2K6NB92
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

61622:SEPTIN11
gene id: 61622:SEPTIN11
uniprot id: A0A2K6QMS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:CCL19
gene id: 61622:CCL19
uniprot id: A0A2K6NZ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:ZADH2
gene id: 61622:ZADH2
uniprot id: A0A2K6PJW8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61622:HSD17B6
gene id: 61622:HSD17B6
uniprot id: A0A2K6QKV2
uniprot id: A0A2K6QKV3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:RPS3
gene id: 61622:RPS3
uniprot id: A0A2K6NDX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: spindle

61622:LOC104666732
gene id: 61622:LOC104666732
uniprot id: A0A2K6NEF4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:HADHB
gene id: 61622:HADHB
uniprot id: A0A2K6NQH6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61622:ARL5B
gene id: 61622:ARL5B
uniprot id: A0A2K6Q2H7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:MS4A6A
gene id: 61622:MS4A6A
uniprot id: A0A2K6QX86
names: Similarity
messages: Belongs to the MS4A family.

61622:OSBPL1A
gene id: 61622:OSBPL1A
uniprot id: A0A2K6RUM9
uniprot id: A0A2K6RUN9
names: Similarity
messages: Belongs to the OSBP family.

61622:C16H9orf78
gene id: 61622:C16H9orf78
uniprot id: A0A2K6R7F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

61622:PARVG
gene id: 61622:PARVG
uniprot id: A0A2K6NZN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

61622:HSPA13
gene id: 61622:HSPA13
uniprot id: A0A2K6Q6T3
uniprot id: A0A2K6Q6T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

61622:TP53RK
gene id: 61622:TP53RK
uniprot id: A0A2K6NC99
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

61622:SSBP1
gene id: 61622:SSBP1
uniprot id: A0A2K6P020
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

61622:SFT2D1
gene id: 61622:SFT2D1
uniprot id: A0A2K6NKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

61622:NUP50
gene id: 61622:NUP50
uniprot id: A0A2K6Q2W6
names: Subcellular Location Annotation
messages: nuclear pore complex

61622:ELL
gene id: 61622:ELL
uniprot id: A0A2K6RBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

61622:KLC4
gene id: 61622:KLC4
uniprot id: A0A2K6RXL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:CCDC39
gene id: 61622:CCDC39
uniprot id: A0A2K6QQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

61622:FABP3
gene id: 61622:FABP3
uniprot id: A0A2K6RE96
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:DOK2
gene id: 61622:DOK2
uniprot id: A0A2K6R174
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

61622:LOC104670640
gene id: 61622:LOC104670640
uniprot id: A0A2K6PR60
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SGTB
gene id: 61622:SGTB
uniprot id: A0A2K6PXA3
names: Similarity
messages: Belongs to the SGT family.

61622:LOC104668600
gene id: 61622:LOC104668600
uniprot id: A0A2K6NLC3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

61622:LOC104681778
gene id: 61622:LOC104681778
uniprot id: A0A2K6RHH4
uniprot id: A0A2K6RHH8
uniprot id: A0A2K6RHI4
uniprot id: A0A2K6RHI8
uniprot id: A0A2K6RHJ7
uniprot id: A0A2K6RHL7
uniprot id: A0A2K6RHL9
uniprot id: A0A2K6RHN1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

61622:UBE2R2
gene id: 61622:UBE2R2
uniprot id: A0A2K6Q710
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:ACTR3
gene id: 61622:ACTR3
uniprot id: A0A2K6Q2E2
names: Similarity
messages: Belongs to the actin family.

61622:ATP6V0D2
gene id: 61622:ATP6V0D2
uniprot id: A0A2K6QQN6
uniprot id: A0A2K6QQR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:RPAP1
gene id: 61622:RPAP1
uniprot id: A0A2K6PW94
names: Similarity
messages: Belongs to the RPAP1 family.

61622:TK2
gene id: 61622:TK2
uniprot id: A0A2K6Q8M3
names: Similarity
messages: Belongs to the DCK/DGK family.

61622:SGMS1
gene id: 61622:SGMS1
uniprot id: A0A2K6RX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

61622:NDUFV3
gene id: 61622:NDUFV3
uniprot id: A0A2K6P303
uniprot id: A0A2K6P330
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

61622:ITM2B
gene id: 61622:ITM2B
uniprot id: A0A2K6RKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

61622:CCS
gene id: 61622:CCS
uniprot id: A0A2K6QL98
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

61622:XPOT
gene id: 61622:XPOT
uniprot id: A0A2K6QJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

61622:HDAC5
gene id: 61622:HDAC5
uniprot id: A0A2K6P0B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

61622:ISCA2
gene id: 61622:ISCA2
uniprot id: A0A2K6P5Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

61622:NID1
gene id: 61622:NID1
uniprot id: A0A2K6NKZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61622:SMG6
gene id: 61622:SMG6
uniprot id: A0A2K6P6S3
uniprot id: A0A2K6P6T5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

61622:SLC10A2
gene id: 61622:SLC10A2
uniprot id: A0A2K6R1M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:FOLH1B
gene id: 61622:FOLH1B
uniprot id: A0A2K6RQ71
uniprot id: A0A2K6RQ75
uniprot id: A0A2K6RQ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61622:PIK3C2B
gene id: 61622:PIK3C2B
uniprot id: A0A2K6Q1P6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:CXCL9
gene id: 61622:CXCL9
uniprot id: A0A2K6Q2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:ARSB
gene id: 61622:ARSB
uniprot id: A0A2K6PJN1
names: Similarity
messages: Belongs to the sulfatase family.

61622:DHRS7B
gene id: 61622:DHRS7B
uniprot id: A0A2K6NLW2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:ZNF326
gene id: 61622:ZNF326
uniprot id: A0A2K6PHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

61622:GCNT4
gene id: 61622:GCNT4
uniprot id: A0A2K6Q8I2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61622:PPCS
gene id: 61622:PPCS
uniprot id: A0A2K6NJB9
names: Similarity
messages: Belongs to the PPC synthetase family.

61622:WSCD2
gene id: 61622:WSCD2
uniprot id: A0A2K6RCC9
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

61622:FAM120B
gene id: 61622:FAM120B
uniprot id: A0A2K6P407
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

61622:COPG1
gene id: 61622:COPG1
uniprot id: A0A2K6PGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61622:MASTL
gene id: 61622:MASTL
uniprot id: A0A2K6NZM5
names: Subcellular Location Annotation
messages: Nucleus
messages: centrosome

61622:RNF40
gene id: 61622:RNF40
uniprot id: A0A2K6N8F8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

61622:KDM1A
gene id: 61622:KDM1A
uniprot id: A0A2K6R0R4
uniprot id: A0A2K6R0V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

61622:ACKR1
gene id: 61622:ACKR1
uniprot id: L7WMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

61622:IMPACT
gene id: 61622:IMPACT
uniprot id: A0A2K6QJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

61622:SLC22A12
gene id: 61622:SLC22A12
uniprot id: A0A2K6P3C1
names: Subcellular Location Annotation
messages: Membrane

61622:GPR137
gene id: 61622:GPR137
uniprot id: A0A2K6QGE4
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

61622:DSG2
gene id: 61622:DSG2
uniprot id: A0A2K6RH63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

61622:MFSD10
gene id: 61622:MFSD10
uniprot id: A0A2K6R5D7
names: Subcellular Location Annotation
messages: Membrane

61622:ADORA1
gene id: 61622:ADORA1
uniprot id: A0A2K6NX56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

61622:LOC104662101
gene id: 61622:LOC104662101
uniprot id: A0A2K6RME0
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:TRIM69
gene id: 61622:TRIM69
uniprot id: A0A2K6QAZ0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PFN1
gene id: 61622:PFN1
uniprot id: A0A2K6PFA7
names: Similarity
messages: Belongs to the profilin family.

61622:REXO2
gene id: 61622:REXO2
uniprot id: A0A2K6QNG0
names: Similarity
messages: Belongs to the oligoribonuclease family.

61622:CCR1
gene id: 61622:CCR1
uniprot id: A0A2K6P8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:LOC104663440
gene id: 61622:LOC104663440
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:C8G
gene id: 61622:C8G
uniprot id: A0A2K6RE65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

61622:GMPPA
gene id: 61622:GMPPA
uniprot id: A0A2K6QQ96
uniprot id: A0A2K6QQC0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

61622:APOB
gene id: 61622:APOB
uniprot id: A0A2K6PZ21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ASB2
gene id: 61622:ASB2
uniprot id: A0A2K6PI77
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:NDUFA10
gene id: 61622:NDUFA10
uniprot id: A0A2K6PBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

61622:SLC30A2
gene id: 61622:SLC30A2
uniprot id: A0A2K6Q7R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:TMTC3
gene id: 61622:TMTC3
uniprot id: A0A2K6NSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

61622:PRKCH
gene id: 61622:PRKCH
uniprot id: A0A2K6P6H6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

61622:PSKH1
gene id: 61622:PSKH1
uniprot id: A0A2K6PCH0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MRPL12
gene id: 61622:MRPL12
uniprot id: A0A2K6NE02
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

61622:HOXC9
gene id: 61622:HOXC9
uniprot id: A0A2K6Q4B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61622:LOC104675814
gene id: 61622:LOC104675814
uniprot id: A0A2K6NAE4
names: Similarity
messages: Belongs to the SSX family.

61622:TAF2
gene id: 61622:TAF2
uniprot id: A0A2K6RB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

61622:SLC7A3
gene id: 61622:SLC7A3
uniprot id: A0A2K6NWF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

61622:SNX18
gene id: 61622:SNX18
uniprot id: A0A2K6QHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

61622:GPRC5A
gene id: 61622:GPRC5A
uniprot id: A0A2K6QG11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PRDM4
gene id: 61622:PRDM4
uniprot id: A0A2K6NG29
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

61622:CEMIP
gene id: 61622:CEMIP
uniprot id: A0A2K6QGN9
names: Similarity
messages: Belongs to the CEMIP family.

61622:C5AR1
gene id: 61622:C5AR1
uniprot id: A0A2K6PY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

61622:IDH3A
gene id: 61622:IDH3A
uniprot id: A0A2K6QA22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:POU5F1
gene id: 61622:POU5F1
uniprot id: A0A2K6NEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61622:DDX50
gene id: 61622:DDX50
uniprot id: A0A2K6PHJ2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

61622:GPR132
gene id: 61622:GPR132
uniprot id: A0A2K6Q4U0
uniprot id: A0A2K6Q4V2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PF4V1
gene id: 61622:PF4V1
uniprot id: A0A2K6QSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:CLIC1
gene id: 61622:CLIC1
uniprot id: A0A2K6NP18
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

61622:GPD1
gene id: 61622:GPD1
uniprot id: A0A2K6RTL8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

61622:TMIGD2
gene id: 61622:TMIGD2
uniprot id: A0A2K6QTQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:DGAT2L6
gene id: 61622:DGAT2L6
uniprot id: A0A2K6QM71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GSTZ1
gene id: 61622:GSTZ1
uniprot id: A0A2K6QT91
uniprot id: A0A2K6QT98
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

61622:SRD5A3
gene id: 61622:SRD5A3
uniprot id: A0A2K6PH65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

61622:PI4KA
gene id: 61622:PI4KA
uniprot id: A0A2K6Q753
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:SLC11A2
gene id: 61622:SLC11A2
uniprot id: A0A2K6R7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

61622:LOC104677852
gene id: 61622:LOC104677852
uniprot id: A0A2K6NHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:UCP1
gene id: 61622:UCP1
uniprot id: A0A2K6PF86
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

61622:AGRP
gene id: 61622:AGRP
uniprot id: A0A2K6RJI3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:OGT
gene id: 61622:OGT
uniprot id: A0A2K6P0T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

61622:MTTP
gene id: 61622:MTTP
uniprot id: A0A2K6PE07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GNAL
gene id: 61622:GNAL
uniprot id: A0A2K6PPJ8
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

61622:SNF8
gene id: 61622:SNF8
uniprot id: A0A2K6R246
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

61622:FAM189A2
gene id: 61622:FAM189A2
uniprot id: A0A2K6QPQ2
names: Similarity
messages: Belongs to the ENTREP family.

61622:FPGS
gene id: 61622:FPGS
uniprot id: A0A2K6RE88
uniprot id: A0A2K6RE98
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

61622:EXTL2
gene id: 61622:EXTL2
uniprot id: A0A2K6PNC7
uniprot id: A0A2K6PNH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ASB4
gene id: 61622:ASB4
uniprot id: A0A2K6QHD1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:RPL11
gene id: 61622:RPL11
uniprot id: A0A2K6QUX6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

61622:FDFT1
gene id: 61622:FDFT1
uniprot id: A0A2K6RJ97
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

61622:PHTF2
gene id: 61622:PHTF2
uniprot id: A0A2K6RAK8
uniprot id: A0A2K6RAQ2
names: Subcellular Location Annotation
messages: Membrane

61622:ATG9A
gene id: 61622:ATG9A
uniprot id: A0A2K6N936
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

61622:LIPM
gene id: 61622:LIPM
uniprot id: A0A2K6PS08
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:ZAR1L
gene id: 61622:ZAR1L
uniprot id: A0A2K6NVA6
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

61622:FTH1
gene id: 61622:FTH1
uniprot id: A0A2K6P455
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:DOK5
gene id: 61622:DOK5
uniprot id: A0A2K6QDT5
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

61622:FOXC2
gene id: 61622:FOXC2
uniprot id: A0A2K6NAR3
names: Subcellular Location Annotation
messages: Nucleus

61622:TET2
gene id: 61622:TET2
uniprot id: A0A2K6NIL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

61622:ELF1
gene id: 61622:ELF1
uniprot id: A0A2K6QFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:PEX14
gene id: 61622:PEX14
uniprot id: A0A2K6N8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

61622:NFRKB
gene id: 61622:NFRKB
uniprot id: A0A2K6QPY0
names: Subcellular Location Annotation
messages: Nucleus

61622:HBEGF
gene id: 61622:HBEGF
uniprot id: A0A2K6P4R0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CLDN20
gene id: 61622:CLDN20
uniprot id: A0A2K6NMJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:FEV
gene id: 61622:FEV
uniprot id: A0A2K6NPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:UBE2S
gene id: 61622:UBE2S
uniprot id: A0A2K6RSS2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:DNAL4
gene id: 61622:DNAL4
uniprot id: A0A2K6Q652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

61622:TAF6
gene id: 61622:TAF6
uniprot id: A0A2K6N7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

61622:NRDE2
gene id: 61622:NRDE2
uniprot id: A0A2K6QZ00
names: Similarity
messages: Belongs to the NRDE2 family.

61622:SEZ6L2
gene id: 61622:SEZ6L2
uniprot id: A0A2K6QQH7
uniprot id: A0A2K6QQH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ZNF622
gene id: 61622:ZNF622
uniprot id: A0A2K6PNV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

61622:NDC1
gene id: 61622:NDC1
uniprot id: A0A2K6PZJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

61622:PSMD11
gene id: 61622:PSMD11
uniprot id: A0A2K6PH42
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

61622:SLC16A6
gene id: 61622:SLC16A6
uniprot id: A0A2K6P337
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104671564
gene id: 61622:LOC104671564
uniprot id: A0A2K6QS48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

61622:APH1B
gene id: 61622:APH1B
uniprot id: A0A2K6NEY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

61622:OSMR
gene id: 61622:OSMR
uniprot id: A0A2K6RPY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61622:TBX20
gene id: 61622:TBX20
uniprot id: A0A2K6QQJ1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:BAZ1B
gene id: 61622:BAZ1B
uniprot id: A0A2K6Q0U1
names: Subcellular Location Annotation
messages: Nucleus

61622:CBX3
gene id: 61622:CBX3
uniprot id: A0A2K6Q394
names: Subcellular Location Annotation
messages: Nucleus

61622:ENTPD4
gene id: 61622:ENTPD4
uniprot id: A0A2K6NKX2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:ABCA8
gene id: 61622:ABCA8
uniprot id: A0A2K6RT92
names: Subcellular Location Annotation
messages: Membrane

61622:ROPN1
gene id: 61622:ROPN1
uniprot id: A0A2K6Q0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

61622:COPS5
gene id: 61622:COPS5
uniprot id: A0A2K6R4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

61622:CRY1
gene id: 61622:CRY1
uniprot id: A0A2K6Q1V1
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

61622:CD70
gene id: 61622:CD70
uniprot id: A0A2K6QZG2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:ZSCAN25
gene id: 61622:ZSCAN25
uniprot id: A0A2K6RGH0
names: Subcellular Location Annotation
messages: Nucleus

61622:ZDHHC21
gene id: 61622:ZDHHC21
uniprot id: A0A2K6NXY3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:SDHD
gene id: 61622:SDHD
uniprot id: A0A2K6Q459
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

61622:LOC104676508
gene id: 61622:LOC104676508
uniprot id: A0A2K6NXG6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:MINDY1
gene id: 61622:MINDY1
uniprot id: A0A2K6QDK6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61622:RPL22L1
gene id: 61622:RPL22L1
uniprot id: A0A2K6QWS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

61622:TXN
gene id: 61622:TXN
uniprot id: A0A2K6QBU5
names: Similarity
messages: Belongs to the thioredoxin family.

61622:LSM2
gene id: 61622:LSM2
uniprot id: A0A2K6P670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

61622:ASPH
gene id: 61622:ASPH
uniprot id: A0A2K6RDU2
uniprot id: A0A2K6RDX9
uniprot id: A0A2K6RE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61622:GPR83
gene id: 61622:GPR83
uniprot id: A0A2K6PKH4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:RNF165
gene id: 61622:RNF165
uniprot id: A0A2K6PQV5
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104670912
gene id: 61622:LOC104670912
uniprot id: A0A2K6NP58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MMP15
gene id: 61622:MMP15
uniprot id: A0A2K6PBH6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:ANKRD34A
gene id: 61622:ANKRD34A
uniprot id: A0A2K6NNT1
names: Similarity
messages: Belongs to the ANKRD34 family.

61622:BST1
gene id: 61622:BST1
uniprot id: A0A2K6ND22
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

61622:LTV1
gene id: 61622:LTV1
uniprot id: A0A2K6RPK0
names: Similarity
messages: Belongs to the LTV1 family.

61622:POLR2F
gene id: 61622:POLR2F
uniprot id: A0A2K6NKA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

61622:ZCCHC8
gene id: 61622:ZCCHC8
uniprot id: A0A2K6P6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

61622:RIPPLY1
gene id: 61622:RIPPLY1
uniprot id: A0A2K6Q809
uniprot id: A0A2K6Q825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

61622:CASC4
gene id: 61622:CASC4
uniprot id: A0A2K6N7U9
uniprot id: A0A2K6N7V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

61622:OPRM1
gene id: 61622:OPRM1
uniprot id: A0A2K6R6H1
uniprot id: A0A2K6R6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

61622:MITF
gene id: 61622:MITF
uniprot id: A0A2K6P6S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61622:BGLAP
gene id: 61622:BGLAP
uniprot id: A0A2K6QIM5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

61622:EEF1D
gene id: 61622:EEF1D
uniprot id: A0A2K6PDC6
uniprot id: A0A2K6PDJ4
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

61622:PRIMPOL
gene id: 61622:PRIMPOL
uniprot id: A0A2K6RG32
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

61622:GOT1
gene id: 61622:GOT1
uniprot id: A0A2K6RTE5
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

61622:MFSD8
gene id: 61622:MFSD8
uniprot id: A0A2K6PL37
uniprot id: A0A2K6PL42
names: Subcellular Location Annotation
messages: Membrane

61622:APCS
gene id: 61622:APCS
uniprot id: A0A2K6QGM2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

61622:TAF12
gene id: 61622:TAF12
uniprot id: A0A2K6NRW6
uniprot id: A0A2K6NRX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

61622:ADM
gene id: 61622:ADM
uniprot id: A0A2K6QVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

61622:BPI
gene id: 61622:BPI
uniprot id: A0A2K6QLR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

61622:WNT16
gene id: 61622:WNT16
uniprot id: A0A2K6PIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:GPR37
gene id: 61622:GPR37
uniprot id: A0A2K6NGZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:IL17A
gene id: 61622:IL17A
uniprot id: A0A2K6QY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61622:TLR3
gene id: 61622:TLR3
uniprot id: A0A2K6NBK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61622:PPM1D
gene id: 61622:PPM1D
uniprot id: A0A2K6QCZ0
names: Similarity
messages: Belongs to the PP2C family.

61622:CETN1
gene id: 61622:CETN1
uniprot id: A0A2K6NM19
names: Similarity
messages: Belongs to the centrin family.

61622:YKT6
gene id: 61622:YKT6
uniprot id: A0A2K6RMJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

61622:GGH
gene id: 61622:GGH
uniprot id: A0A2K6QE55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

61622:SLC7A6OS
gene id: 61622:SLC7A6OS
uniprot id: A0A2K6PHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

61622:SAE1
gene id: 61622:SAE1
uniprot id: A0A2K6PF78
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61622:LOC104676512
gene id: 61622:LOC104676512
uniprot id: A0A2K6NQ88
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:GRK5
gene id: 61622:GRK5
uniprot id: A0A2K6RJ72
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:TMPRSS6
gene id: 61622:TMPRSS6
uniprot id: A0A2K6RQB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CELF3
gene id: 61622:CELF3
uniprot id: A0A2K6RSF3
uniprot id: A0A2K6RSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

61622:NDC80
gene id: 61622:NDC80
uniprot id: A0A2K6QZ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61622:GINS2
gene id: 61622:GINS2
uniprot id: A0A2K6QXS2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

61622:SFRP5
gene id: 61622:SFRP5
uniprot id: A0A2K6P6X5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TATDN3
gene id: 61622:TATDN3
uniprot id: A0A2K6R5D2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61622:TCEA1
gene id: 61622:TCEA1
uniprot id: A0A2K6N7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

61622:TEFM
gene id: 61622:TEFM
uniprot id: A0A2K6P6R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

61622:LOC104659773
gene id: 61622:LOC104659773
uniprot id: A0A2K6P4W5
names: Similarity
messages: Belongs to the histone H2B family.

61622:CLEC12B
gene id: 61622:CLEC12B
uniprot id: A0A2K6P8A3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PCSK1
gene id: 61622:PCSK1
uniprot id: A0A2K6PLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

61622:KEG34 p09
gene id: 61622:KEG34_p09
uniprot id: Q15GN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

61622:MYH13
gene id: 61622:MYH13
uniprot id: A0A2K6NT21
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:SLC9A3R1
gene id: 61622:SLC9A3R1
uniprot id: A0A2K6PSC0
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

61622:LOC104659546
gene id: 61622:LOC104659546
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:KIAA1324
gene id: 61622:KIAA1324
uniprot id: A0A2K6RL21
uniprot id: A0A2K6RL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

61622:DHTKD1
gene id: 61622:DHTKD1
uniprot id: A0A2K6NQ23
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

61622:PSMB1
gene id: 61622:PSMB1
uniprot id: A0A2K6Q7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:RPS6KA4
gene id: 61622:RPS6KA4
uniprot id: A0A2K6QXX5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61622:HPSE2
gene id: 61622:HPSE2
uniprot id: A0A2K6RU46
uniprot id: A0A2K6RU52
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61622:DNAAF3
gene id: 61622:DNAAF3
uniprot id: A0A2K6P8J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

61622:RPS15
gene id: 61622:RPS15
uniprot id: A0A2K6QL48
uniprot id: A0A2K6QL61
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the small ribosomal subunit.

61622:F2RL3
gene id: 61622:F2RL3
uniprot id: A0A2K6NU04
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:KIF12
gene id: 61622:KIF12
uniprot id: A0A2K6Q2G1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:DAXX
gene id: 61622:DAXX
uniprot id: A0A2K6PMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

61622:SNUPN
gene id: 61622:SNUPN
uniprot id: A0A2K6RII2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

61622:DONSON
gene id: 61622:DONSON
uniprot id: A0A2K6R6U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

61622:LHX1
gene id: 61622:LHX1
uniprot id: A0A2K6NW71
names: Subcellular Location Annotation
messages: Nucleus

61622:AWAT2
gene id: 61622:AWAT2
uniprot id: A0A2K6NTY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

61622:MUTYH
gene id: 61622:MUTYH
uniprot id: A0A2K6NW67
uniprot id: A0A2K6NW72
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

61622:PSMC5
gene id: 61622:PSMC5
uniprot id: A0A2K6RIQ0
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:MTAP
gene id: 61622:MTAP
uniprot id: A0A2K6NAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

61622:KIF18A
gene id: 61622:KIF18A
uniprot id: A0A2K6RWD5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:FITM2
gene id: 61622:FITM2
uniprot id: A0A2K6RA45
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PTGES2
gene id: 61622:PTGES2
uniprot id: A0A2K6R3A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

61622:IL17F
gene id: 61622:IL17F
uniprot id: A0A2K6NED4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61622:TADA2A
gene id: 61622:TADA2A
uniprot id: A0A2K6RFE7
names: Subcellular Location Annotation
messages: Nucleus

61622:ACAT2
gene id: 61622:ACAT2
uniprot id: A0A2K6P8X7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61622:AGAP1
gene id: 61622:AGAP1
uniprot id: A0A2K6Q7R5
names: Similarity
messages: Belongs to the centaurin gamma-like family.

61622:KCNC4
gene id: 61622:KCNC4
uniprot id: A0A2K6RGG9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:HAGHL
gene id: 61622:HAGHL
uniprot id: A0A2K6PVJ4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:LOC104667124
gene id: 61622:LOC104667124
uniprot id: A0A2K6N9I7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61622:RRH
gene id: 61622:RRH
uniprot id: A0A2K6QKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:CLPS
gene id: 61622:CLPS
uniprot id: A0A2K6PSS2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

61622:SATB1
gene id: 61622:SATB1
uniprot id: A0A2K6QY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:POU2F1
gene id: 61622:POU2F1
uniprot id: A0A2K6NE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

61622:LYG2
gene id: 61622:LYG2
uniprot id: A0A2K6PVC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

61622:LOC104658882
gene id: 61622:LOC104658882
uniprot id: A0A2K6PJB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:PARP11
gene id: 61622:PARP11
uniprot id: A0A2K6PY81
uniprot id: A0A2K6PY86
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:LIG3
gene id: 61622:LIG3
uniprot id: A0A2K6NLY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

61622:GORAB
gene id: 61622:GORAB
uniprot id: A0A2K6QWA2
names: Similarity
messages: Belongs to the GORAB family.

61622:KIF26A
gene id: 61622:KIF26A
uniprot id: A0A2K6RGN2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:CANX
gene id: 61622:CANX
uniprot id: A0A2K6PWJ2
names: Similarity
messages: Belongs to the calreticulin family.

61622:SLC51A
gene id: 61622:SLC51A
uniprot id: A0A2K6PG19
names: Subcellular Location Annotation
messages: Membrane

61622:LRP3
gene id: 61622:LRP3
uniprot id: A0A2K6RW87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IZUMO1
gene id: 61622:IZUMO1
uniprot id: A0A2K6NEL4
names: Similarity
messages: Belongs to the Izumo family.

61622:JUNB
gene id: 61622:JUNB
uniprot id: A0A2K6NQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

61622:FLAD1
gene id: 61622:FLAD1
uniprot id: A0A2K6RTE9
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

61622:LOC104680801
gene id: 61622:LOC104680801
uniprot id: A0A2K6NG68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:ZDHHC4
gene id: 61622:ZDHHC4
uniprot id: A0A2K6NC28
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:MAP3K11
gene id: 61622:MAP3K11
uniprot id: A0A2K6PMA3
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

61622:CPVL
gene id: 61622:CPVL
uniprot id: A0A2K6R8H3
names: Similarity
messages: Belongs to the peptidase S10 family.

61622:AFMID
gene id: 61622:AFMID
uniprot id: A0A2K6PFT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

61622:POLG2
gene id: 61622:POLG2
uniprot id: A0A2K6NVB0
names: Subcellular Location Annotation
messages: Mitochondrion

61622:DLL4
gene id: 61622:DLL4
uniprot id: A0A2K6N8K6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61622:NDST1
gene id: 61622:NDST1
uniprot id: A0A2K6REY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

61622:CBFB
gene id: 61622:CBFB
uniprot id: A0A2K6PDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

61622:SEPTIN14
gene id: 61622:SEPTIN14
uniprot id: A0A2K6Q229
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:DNASE1
gene id: 61622:DNASE1
uniprot id: A0A2K6QY06
names: Similarity
messages: Belongs to the DNase I family.

61622:ESS2
gene id: 61622:ESS2
uniprot id: A0A2K6NH30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

61622:EHF
gene id: 61622:EHF
uniprot id: A0A2K6QMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:TLE1
gene id: 61622:TLE1
uniprot id: A0A2K6NZD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

61622:PRKCA
gene id: 61622:PRKCA
uniprot id: A0A2K6RMH9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

61622:LOC104676331
gene id: 61622:LOC104676331
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TBX22
gene id: 61622:TBX22
uniprot id: A0A2K6NAW8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:SLC1A1
gene id: 61622:SLC1A1
uniprot id: A0A2K6PJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61622:TRMT44
gene id: 61622:TRMT44
uniprot id: A0A2K6PD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

61622:REM1
gene id: 61622:REM1
uniprot id: A0A2K6R7S0
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61622:MRPS33
gene id: 61622:MRPS33
uniprot id: A0A2K6Q6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

61622:RAD23A
gene id: 61622:RAD23A
uniprot id: A0A2K6QWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

61622:LOC104676137
gene id: 61622:LOC104676137
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:PFKM
gene id: 61622:PFKM
uniprot id: A0A2K6Q3U0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DTX4
gene id: 61622:DTX4
uniprot id: A0A2K6QG46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61622:DTX2
gene id: 61622:DTX2
uniprot id: A0A2K6NR95
uniprot id: A0A2K6NRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61622:MLF2
gene id: 61622:MLF2
uniprot id: A0A2K6QMZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

61622:PLAC8L1
gene id: 61622:PLAC8L1
uniprot id: A0A2K6QCH7
names: Similarity
messages: Belongs to the cornifelin family.

61622:FAM102B
gene id: 61622:FAM102B
uniprot id: A0A2K6R7J5
names: Similarity
messages: Belongs to the EEIG family.

61622:HMGCS1
gene id: 61622:HMGCS1
uniprot id: A0A2K6RIH9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

61622:SLC27A5
gene id: 61622:SLC27A5
uniprot id: A0A2K6RJ55
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:PTGIS
gene id: 61622:PTGIS
uniprot id: A0A2K6RG59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
messages: Endoplasmic reticulum membrane

61622:EEF1G
gene id: 61622:EEF1G
uniprot id: A0A2K6RD95
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

61622:NIM1K
gene id: 61622:NIM1K
uniprot id: A0A2K6NKX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:NECTIN4
gene id: 61622:NECTIN4
uniprot id: A0A2K6QPR4
uniprot id: A0A2K6QPR9
names: Similarity
messages: Belongs to the nectin family.

61622:HSF1
gene id: 61622:HSF1
uniprot id: A0A2K6NA02
uniprot id: A0A2K6NA20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:SLC10A1
gene id: 61622:SLC10A1
uniprot id: A0A2K6R9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:ZDHHC2
gene id: 61622:ZDHHC2
uniprot id: A0A2K6QGA7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:BABAM2
gene id: 61622:BABAM2
uniprot id: A0A2K6Q0Z4
uniprot id: A0A2K6Q100
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

61622:C15H11orf88
gene id: 61622:C15H11orf88
uniprot id: A0A2K6QUP9
uniprot id: A0A2K6QUS1
names: Similarity
messages: Belongs to the HOATZ family.

61622:JRKL
gene id: 61622:JRKL
uniprot id: A0A2K6NQM0
names: Subcellular Location Annotation
messages: Nucleus

61622:OXSR1
gene id: 61622:OXSR1
uniprot id: A0A2K6PQU6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

61622:SH3BP5
gene id: 61622:SH3BP5
uniprot id: A0A2K6PGT7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

61622:LOC104656160
gene id: 61622:LOC104656160
uniprot id: A0A2K6RW11
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

61622:LOC104660123
gene id: 61622:LOC104660123
uniprot id: A0A2K6RD37
names: Subcellular Location Annotation
messages: Membrane

61622:ABCG8
gene id: 61622:ABCG8
uniprot id: A0A2K6RS80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61622:GPRC5D
gene id: 61622:GPRC5D
uniprot id: A0A2K6RWL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SERPINE2
gene id: 61622:SERPINE2
uniprot id: A0A2K6QYN7
names: Similarity
messages: Belongs to the serpin family.

61622:ABRACL
gene id: 61622:ABRACL
uniprot id: A0A2K6QMT3
names: Similarity
messages: Belongs to the costars family.

61622:GLYCTK
gene id: 61622:GLYCTK
uniprot id: A0A2K6Q6M5
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

61622:RALYL
gene id: 61622:RALYL
uniprot id: A0A2K6NNQ2
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

61622:ABAT
gene id: 61622:ABAT
uniprot id: A0A2K6QCV5
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

61622:ARID5B
gene id: 61622:ARID5B
uniprot id: A0A2K6QUI3
uniprot id: A0A2K6QUK9
names: Similarity
messages: Belongs to the ARID5B family.

61622:FUT7
gene id: 61622:FUT7
uniprot id: A0A2K6QU35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61622:LTK
gene id: 61622:LTK
uniprot id: A0A2K6PM76
uniprot id: A0A2K6PM85
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

61622:SLC2A13
gene id: 61622:SLC2A13
uniprot id: A0A2K6P3L8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:FBP2
gene id: 61622:FBP2
uniprot id: A0A2K6QW76
names: Similarity
messages: Belongs to the FBPase class 1 family.

61622:LOC104660034
gene id: 61622:LOC104660034
uniprot id: A0A2K6QDG5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:RBM47
gene id: 61622:RBM47
uniprot id: A0A2K6RQI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

61622:COL4A4
gene id: 61622:COL4A4
uniprot id: A0A2K6PCA1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:TECR
gene id: 61622:TECR
uniprot id: A0A2K6QZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PHKG2
gene id: 61622:PHKG2
uniprot id: A0A2K6PU67
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

61622:HOXA11
gene id: 61622:HOXA11
uniprot id: A0A2K6P5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:SLC22A4
gene id: 61622:SLC22A4
uniprot id: A0A2K6PE03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Interacts with PDZK1.

61622:LYRM2
gene id: 61622:LYRM2
uniprot id: A0A2K6NAQ2
names: Similarity
messages: Belongs to the complex I LYR family.

61622:LOC104659891
gene id: 61622:LOC104659891
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104664024
gene id: 61622:LOC104664024
uniprot id: A0A2K6NQP8
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:EXOC7
gene id: 61622:EXOC7
uniprot id: A0A2K6NVU5
uniprot id: A0A2K6NVV2
uniprot id: A0A2K6NVV8
uniprot id: A0A2K6NVW1
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:ATP6V0D1
gene id: 61622:ATP6V0D1
uniprot id: A0A2K6NDB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:CAD
gene id: 61622:CAD
uniprot id: A0A2K6QB99
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

61622:VBP1
gene id: 61622:VBP1
uniprot id: A0A2K6RJD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

61622:BLOC1S6
gene id: 61622:BLOC1S6
uniprot id: A0A2K6ND45
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

61622:SLC7A9
gene id: 61622:SLC7A9
uniprot id: A0A2K6Q8T7
names: Subcellular Location Annotation
messages: Membrane

61622:CXCL8
gene id: 61622:CXCL8
uniprot id: A0A2K6RUC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

61622:BRIX1
gene id: 61622:BRIX1
uniprot id: A0A2K6PBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

61622:NUDT6
gene id: 61622:NUDT6
uniprot id: A0A2K6PHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

61622:TUB
gene id: 61622:TUB
uniprot id: A0A2K6P623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

61622:N6AMT1
gene id: 61622:N6AMT1
uniprot id: A0A2K6NTQ3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

61622:CACNA1D
gene id: 61622:CACNA1D
uniprot id: A0A2K6Q3E6
uniprot id: A0A2K6Q3F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

61622:CPEB4
gene id: 61622:CPEB4
uniprot id: A0A2K6NZ37
uniprot id: A0A2K6NZ38
names: Similarity
messages: Belongs to the RRM CPEB family.

61622:SUV39H1
gene id: 61622:SUV39H1
uniprot id: A0A2K6PE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

61622:GCK
gene id: 61622:GCK
uniprot id: A0A2K6Q4K0
names: Similarity
messages: Belongs to the hexokinase family.

61622:SEPTIN12
gene id: 61622:SEPTIN12
uniprot id: A0A2K6NWN0
uniprot id: A0A2K6NWN1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

61622:LOC104681679
gene id: 61622:LOC104681679
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:NUP58
gene id: 61622:NUP58
uniprot id: A0A2K6NIQ1
names: Subcellular Location Annotation
messages: nuclear pore complex

61622:HNRNPA1
gene id: 61622:HNRNPA1
uniprot id: A0A2K6P8W5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104654195
gene id: 61622:LOC104654195
uniprot id: A0A2K6PIK4
names: Similarity
messages: Belongs to the COX20 family.

61622:HTR2A
gene id: 61622:HTR2A
uniprot id: A0A2K6NX03
uniprot id: A0A2K6NX35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

61622:TBPL1
gene id: 61622:TBPL1
uniprot id: A0A2K6QX77
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

61622:DMBX1
gene id: 61622:DMBX1
uniprot id: A0A2K6NGU9
names: Subcellular Location Annotation
messages: Nucleus

61622:MED6
gene id: 61622:MED6
uniprot id: A0A2K6NHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61622:HMGN4
gene id: 61622:HMGN4
uniprot id: A0A2K6NNM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

61622:PPME1
gene id: 61622:PPME1
uniprot id: A0A2K6PDL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

61622:LOC104680869
gene id: 61622:LOC104680869
uniprot id: A0A2K6NYN8
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

61622:SERPINA4
gene id: 61622:SERPINA4
uniprot id: A0A2K6NE15
names: Similarity
messages: Belongs to the serpin family.

61622:RRP12
gene id: 61622:RRP12
uniprot id: A0A2K6PJI0
names: Similarity
messages: Belongs to the RRP12 family.

61622:VAMP7
gene id: 61622:VAMP7
uniprot id: A0A2K6NMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:NIF3L1
gene id: 61622:NIF3L1
uniprot id: A0A2K6R9J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

61622:EFNB2
gene id: 61622:EFNB2
uniprot id: A0A2K6RIP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:XYLB
gene id: 61622:XYLB
uniprot id: A0A2K6RGB9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

61622:CASP5
gene id: 61622:CASP5
uniprot id: A0A2K6P236
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:CPXM1
gene id: 61622:CPXM1
uniprot id: A0A2K6PEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61622:FAM102A
gene id: 61622:FAM102A
uniprot id: A0A2K6QBE7
names: Similarity
messages: Belongs to the EEIG family.

61622:HSBP1
gene id: 61622:HSBP1
uniprot id: A0A2K6P8F0
names: Similarity
messages: Belongs to the HSBP1 family.

61622:LOC104654619
gene id: 61622:LOC104654619
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ATG13
gene id: 61622:ATG13
uniprot id: A0A2K6PAZ8
uniprot id: A0A2K6PB07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

61622:AMIGO2
gene id: 61622:AMIGO2
uniprot id: A0A2K6NIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

61622:LOC104678627
gene id: 61622:LOC104678627
uniprot id: A0A2K6NA16
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TMEM14A
gene id: 61622:TMEM14A
uniprot id: A0A2K6R5M6
names: Similarity
messages: Belongs to the TMEM14 family.

61622:HIGD1B
gene id: 61622:HIGD1B
uniprot id: A0A2K6RMQ3
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

61622:RCAN2
gene id: 61622:RCAN2
uniprot id: A0A2K6PIC6
uniprot id: A0A2K6PIE6
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

61622:RRS1
gene id: 61622:RRS1
uniprot id: A0A2K6NGJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

61622:NCK2
gene id: 61622:NCK2
uniprot id: A0A2K6NSJ1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

61622:NODAL
gene id: 61622:NODAL
uniprot id: A0A2K6QIN4
names: Similarity
messages: Belongs to the TGF-beta family.

61622:PWP2
gene id: 61622:PWP2
uniprot id: A0A2K6PG61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

61622:REEP5
gene id: 61622:REEP5
uniprot id: A0A2K6NNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

61622:SLC25A20
gene id: 61622:SLC25A20
uniprot id: A0A2K6PM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:CKAP2
gene id: 61622:CKAP2
uniprot id: A0A2K6RQC5
names: Similarity
messages: Belongs to the CKAP2 family.

61622:HTR1E
gene id: 61622:HTR1E
uniprot id: A0A2K6NK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:STX16
gene id: 61622:STX16
uniprot id: A0A2K6RQJ4
uniprot id: A0A2K6RQL4
names: Similarity
messages: Belongs to the syntaxin family.

61622:NAT9
gene id: 61622:NAT9
uniprot id: A0A2K6NM18
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

61622:HMGB2
gene id: 61622:HMGB2
uniprot id: A0A2K6NV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:LOC104681686
gene id: 61622:LOC104681686
uniprot id: A0A2K6QKB4
uniprot id: A0A2K6QKC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TH
gene id: 61622:TH
uniprot id: A0A2K6RK40
uniprot id: A0A2K6RK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

61622:CD163
gene id: 61622:CD163
uniprot id: A0A2K6PQB6
uniprot id: A0A2K6PQC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TFAP2B
gene id: 61622:TFAP2B
uniprot id: A0A2K6Q910
names: Similarity
messages: Belongs to the AP-2 family.

61622:GALM
gene id: 61622:GALM
uniprot id: A0A2K6RCK4
uniprot id: A0A2K6RCN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

61622:PINLYP
gene id: 61622:PINLYP
uniprot id: A0A2K6PMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

61622:IGFBP6
gene id: 61622:IGFBP6
uniprot id: A0A2K6NW82
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:OSBP
gene id: 61622:OSBP
uniprot id: A0A2K6RKN0
names: Similarity
messages: Belongs to the OSBP family.

61622:IL11RA
gene id: 61622:IL11RA
uniprot id: A0A2K6RH39
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

61622:KRT17
gene id: 61622:KRT17
uniprot id: A0A2K6P1Q6
names: Similarity
messages: Belongs to the intermediate filament family.

61622:NUBP1
gene id: 61622:NUBP1
uniprot id: A0A2K6P6P8
uniprot id: A0A2K6P6T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

61622:UBXN1
gene id: 61622:UBXN1
uniprot id: A0A2K6R151
uniprot id: A0A2K6R152
names: Subcellular Location Annotation
messages: Cytoplasm

61622:CXXC1
gene id: 61622:CXXC1
uniprot id: A0A2K6RHF4
names: Subcellular Location Annotation
messages: Nucleus

61622:SRPX
gene id: 61622:SRPX
uniprot id: A0A2K6PD00
uniprot id: A0A2K6PD36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MAPK10
gene id: 61622:MAPK10
uniprot id: A0A2K6QJ79
uniprot id: A0A2K6QJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

61622:NRG1
gene id: 61622:NRG1
uniprot id: A0A2K6QJD6
uniprot id: A0A2K6QJD8
uniprot id: A0A2K6QJE7
uniprot id: A0A2K6QJF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

61622:OPRD1
gene id: 61622:OPRD1
uniprot id: A0A2K6P159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SGTA
gene id: 61622:SGTA
uniprot id: A0A2K6NJH1
names: Similarity
messages: Belongs to the SGT family.

61622:GABRA1
gene id: 61622:GABRA1
uniprot id: A0A2K6RHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LOC104666619
gene id: 61622:LOC104666619
uniprot id: A0A2K6N6Y1
names: Similarity
messages: Belongs to the MHC class II family.

61622:CDK5RAP3
gene id: 61622:CDK5RAP3
uniprot id: A0A2K6RQ86
names: Similarity
messages: Belongs to the CDK5RAP3 family.

61622:TRMT6
gene id: 61622:TRMT6
uniprot id: A0A2K6RUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

61622:DHRS9
gene id: 61622:DHRS9
uniprot id: A0A2K6QFB8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:DDIT3
gene id: 61622:DDIT3
uniprot id: A0A2K6NQ93
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

61622:PREPL
gene id: 61622:PREPL
uniprot id: A0A2K6R7L5
names: Similarity
messages: Belongs to the peptidase S9A family.

61622:AP1G1
gene id: 61622:AP1G1
uniprot id: A0A2K6NQ98
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:SMIM24
gene id: 61622:SMIM24
uniprot id: A0A2K6PMJ6
names: Subcellular Location Annotation
messages: Membrane

61622:CDK14
gene id: 61622:CDK14
uniprot id: A0A2K6NNN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SMARCA2
gene id: 61622:SMARCA2
uniprot id: A0A2K6NK76
names: Subcellular Location Annotation
messages: Nucleus

61622:FAM135A
gene id: 61622:FAM135A
uniprot id: A0A2K6RBZ2
names: Similarity
messages: Belongs to the FAM135 family.

61622:TRIM77
gene id: 61622:TRIM77
uniprot id: A0A2K6P654
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LIPT2
gene id: 61622:LIPT2
uniprot id: A0A2K6RSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

61622:SH3RF2
gene id: 61622:SH3RF2
uniprot id: A0A2K6RLZ6
names: Similarity
messages: Belongs to the SH3RF family.

61622:FOXA3
gene id: 61622:FOXA3
uniprot id: A0A2K6R7H6
names: Subcellular Location Annotation
messages: Nucleus

61622:TPT1
gene id: 61622:TPT1
uniprot id: A0A2K6RP92
names: Similarity
messages: Belongs to the TCTP family.

61622:LOC104656372
gene id: 61622:LOC104656372
uniprot id: A0A2K6NC70
names: Subcellular Location Annotation
messages: Membrane

61622:SH2D1A
gene id: 61622:SH2D1A
uniprot id: A0A2K6Q3D7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

61622:C12H1orf174
gene id: 61622:C12H1orf174
uniprot id: A0A2K6QC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

61622:POLD2
gene id: 61622:POLD2
uniprot id: A0A2K6RMP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

61622:HGF
gene id: 61622:HGF
uniprot id: A0A2K6NWB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

61622:RPS27
gene id: 61622:RPS27
uniprot id: A0A2K6N9I7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61622:NOC3L
gene id: 61622:NOC3L
uniprot id: A0A2K6NXP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

61622:SORCS2
gene id: 61622:SORCS2
uniprot id: A0A2K6QJE1
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

61622:BNIP3
gene id: 61622:BNIP3
uniprot id: A0A2K6PYI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

61622:MED11
gene id: 61622:MED11
uniprot id: A0A2K6RWJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:S100A11
gene id: 61622:S100A11
uniprot id: A0A2K6Q750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

61622:DAO
gene id: 61622:DAO
uniprot id: A0A2K6NXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

61622:CACNG3
gene id: 61622:CACNG3
uniprot id: A0A2K6QPP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

61622:PIWIL2
gene id: 61622:PIWIL2
uniprot id: A0A2K6QH59
names: Similarity
messages: Belongs to the argonaute family.

61622:SEMA3B
gene id: 61622:SEMA3B
uniprot id: A0A2K6QIG3
names: Similarity
messages: Belongs to the semaphorin family.

61622:TMEM182
gene id: 61622:TMEM182
uniprot id: A0A2K6N7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

61622:GRK3
gene id: 61622:GRK3
uniprot id: A0A2K6PAZ9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:TTYH1
gene id: 61622:TTYH1
uniprot id: A0A2K6R921
uniprot id: A0A2K6R938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

61622:ZWILCH
gene id: 61622:ZWILCH
uniprot id: A0A2K6RC90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

61622:ATP1A4
gene id: 61622:ATP1A4
uniprot id: A0A2K6PZ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

61622:GLT6D1
gene id: 61622:GLT6D1
uniprot id: A0A2K6NXZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

61622:FMO5
gene id: 61622:FMO5
uniprot id: A0A2K6NKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:USP33
gene id: 61622:USP33
uniprot id: A0A2K6NFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

61622:EFNA1
gene id: 61622:EFNA1
uniprot id: A0A2K6RK82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104655977
gene id: 61622:LOC104655977
uniprot id: A0A2K6RH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

61622:EFTUD2
gene id: 61622:EFTUD2
uniprot id: A0A2K6RE22
names: Subcellular Location Annotation
messages: Nucleus

61622:LACC1
gene id: 61622:LACC1
uniprot id: A0A2K6QU78
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

61622:LOC104659611
gene id: 61622:LOC104659611
uniprot id: A0A2K6PIT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

61622:PTK2B
gene id: 61622:PTK2B
uniprot id: A0A2K6RDP1
uniprot id: A0A2K6RDT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

61622:PDRG1
gene id: 61622:PDRG1
uniprot id: A0A2K6QZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

61622:FAS
gene id: 61622:FAS
uniprot id: A0A2K6QCZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

61622:LTC4S
gene id: 61622:LTC4S
uniprot id: A0A2K6PTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TARDBP
gene id: 61622:TARDBP
uniprot id: A0A2K6QV39
names: Subcellular Location Annotation
messages: Nucleus

61622:REEP4
gene id: 61622:REEP4
uniprot id: A0A2K6PHV5
uniprot id: A0A2K6PHV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:YIPF5
gene id: 61622:YIPF5
uniprot id: A0A2K6NKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61622:STK4
gene id: 61622:STK4
uniprot id: A0A2K6RTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

61622:PRM2
gene id: 61622:PRM2
uniprot id: A0A2K6R0M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

61622:DDRGK1
gene id: 61622:DDRGK1
uniprot id: A0A2K6PHK5
names: Similarity
messages: Belongs to the DDRGK1 family.

61622:ACP5
gene id: 61622:ACP5
uniprot id: A0A2K6PV76
names: Cofactor
messages: Binds 2 iron ions per subunit.

61622:ETS1
gene id: 61622:ETS1
uniprot id: A0A2K6NIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

61622:RSAD2
gene id: 61622:RSAD2
uniprot id: A0A2K6N8K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

61622:ADAMTS14
gene id: 61622:ADAMTS14
uniprot id: A0A2K6QRF2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:KCNJ11
gene id: 61622:KCNJ11
uniprot id: A0A2K6NS72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

61622:LOC104661582
gene id: 61622:LOC104661582
uniprot id: A0A2K6P7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:TCEA3
gene id: 61622:TCEA3
uniprot id: A0A2K6NK13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

61622:RDH11
gene id: 61622:RDH11
uniprot id: A0A2K6RH31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:LOC104664605
gene id: 61622:LOC104664605
uniprot id: A0A2K6RXI7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:LIN28B
gene id: 61622:LIN28B
uniprot id: A0A2K6PRK4
names: Similarity
messages: Belongs to the lin-28 family.

61622:PTS
gene id: 61622:PTS
uniprot id: A0A2K6PRC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

61622:UBE2D2
gene id: 61622:UBE2D2
uniprot id: A0A2K6QJE9
uniprot id: A0A2K6QJF9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PRPS1
gene id: 61622:PRPS1
uniprot id: A0A2K6PL50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

61622:CAMLG
gene id: 61622:CAMLG
uniprot id: A0A2K6NKK0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

61622:NOTCH4
gene id: 61622:NOTCH4
uniprot id: A0A2K6PDV9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

61622:LOC104667224
gene id: 61622:LOC104667224
uniprot id: A0A2K6Q1L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

61622:PLPBP
gene id: 61622:PLPBP
uniprot id: A0A2K6NPJ9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

61622:APAF1
gene id: 61622:APAF1
uniprot id: A0A2K6PZZ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

61622:PIGH
gene id: 61622:PIGH
uniprot id: A0A2K6RND4
names: Similarity
messages: Belongs to the PIGH family.

61622:LOC104662954
gene id: 61622:LOC104662954
uniprot id: A0A2K6RNY3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61622:RNF185
gene id: 61622:RNF185
uniprot id: A0A2K6PI97
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

61622:PLIN2
gene id: 61622:PLIN2
uniprot id: A0A2K6QQF9
names: Similarity
messages: Belongs to the perilipin family.

61622:NAA35
gene id: 61622:NAA35
uniprot id: A0A2K6P7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

61622:SLC35B4
gene id: 61622:SLC35B4
uniprot id: A0A2K6RVA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

61622:APIP
gene id: 61622:APIP
uniprot id: A0A2K6RRS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

61622:CNN2
gene id: 61622:CNN2
uniprot id: A0A2K6NZ13
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

61622:PFDN2
gene id: 61622:PFDN2
uniprot id: A0A2K6RUA8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61622:DEDD2
gene id: 61622:DEDD2
uniprot id: A0A2K6QB96
names: Subcellular Location Annotation
messages: nucleolus

61622:PFDN6
gene id: 61622:PFDN6
uniprot id: A0A2K6RH00
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61622:SGCB
gene id: 61622:SGCB
uniprot id: A0A2K6QSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

61622:STPG1
gene id: 61622:STPG1
uniprot id: A0A2K6QNR4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:FGF20
gene id: 61622:FGF20
uniprot id: A0A2K6P4K8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:LOC104666890
gene id: 61622:LOC104666890
uniprot id: A0A2K6RHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

61622:MRPL37
gene id: 61622:MRPL37
uniprot id: A0A2K6PGP1
names: Subcellular Location Annotation
messages: Mitochondrion

61622:SLC31A2
gene id: 61622:SLC31A2
uniprot id: A0A2K6PP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:EIF3H
gene id: 61622:EIF3H
uniprot id: A0A2K6PN16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

61622:SLC10A3
gene id: 61622:SLC10A3
uniprot id: A0A2K6RLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:LOC104679365
gene id: 61622:LOC104679365
uniprot id: A0A2K6NA85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

61622:RIF1
gene id: 61622:RIF1
uniprot id: A0A2K6NUG6
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

61622:ATG7
gene id: 61622:ATG7
uniprot id: A0A2K6R1U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

61622:PAX8
gene id: 61622:PAX8
uniprot id: A0A2K6QAU3
uniprot id: A0A2K6QAV3
uniprot id: A0A2K6QAV4
names: Subcellular Location Annotation
messages: Nucleus

61622:PRKAR1B
gene id: 61622:PRKAR1B
uniprot id: A0A2K6PPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61622:H1-4
gene id: 61622:H1-4
uniprot id: A0A2K6NP62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61622:SLC5A2
gene id: 61622:SLC5A2
uniprot id: A0A2K6PNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:PKM
gene id: 61622:PKM
uniprot id: A0A2K6QME9
uniprot id: A0A2K6QMG8
names: Similarity
messages: Belongs to the pyruvate kinase family.

61622:AHR
gene id: 61622:AHR
uniprot id: A0A2K6PJY6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:PIGN
gene id: 61622:PIGN
uniprot id: A0A2K6NND4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

61622:MFAP2
gene id: 61622:MFAP2
uniprot id: A0A2K6RXL3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:DR1
gene id: 61622:DR1
uniprot id: A0A2K6Q1A2
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

61622:RNF170
gene id: 61622:RNF170
uniprot id: A0A2K6Q002
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PAXBP1
gene id: 61622:PAXBP1
uniprot id: A0A2K6NA03
names: Similarity
messages: Belongs to the GCF family.

61622:KAT5
gene id: 61622:KAT5
uniprot id: A0A2K6RDA6
uniprot id: A0A2K6RDD8
uniprot id: A0A2K6RDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

61622:IL6
gene id: 61622:IL6
uniprot id: A0A2K6NAR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

61622:LOC104658504
gene id: 61622:LOC104658504
uniprot id: A0A2K6P2N9
names: Similarity
messages: Belongs to the intermediate filament family.

61622:MS4A10
gene id: 61622:MS4A10
uniprot id: A0A2K6QVV3
names: Similarity
messages: Belongs to the MS4A family.

61622:NAPA
gene id: 61622:NAPA
uniprot id: A0A2K6QEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

61622:LIPK
gene id: 61622:LIPK
uniprot id: A0A2K6PAE5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:SDC4
gene id: 61622:SDC4
uniprot id: A0A2K6RN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

61622:LCN6
gene id: 61622:LCN6
uniprot id: A0A2K6PHT4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:GCNT1
gene id: 61622:GCNT1
uniprot id: A0A2K6N9L7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61622:SYT16
gene id: 61622:SYT16
uniprot id: A0A2K6QJX1
names: Similarity
messages: Belongs to the synaptotagmin family.

61622:GBP6
gene id: 61622:GBP6
uniprot id: A0A2K6PIY2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:LOC104661254
gene id: 61622:LOC104661254
uniprot id: A0A2K6QG58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

61622:TAP2
gene id: 61622:TAP2
uniprot id: A0A2K6PQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

61622:SENP6
gene id: 61622:SENP6
uniprot id: A0A2K6QV11
uniprot id: A0A2K6QV20
names: Similarity
messages: Belongs to the peptidase C48 family.

61622:IL1RL1
gene id: 61622:IL1RL1
uniprot id: A0A2K6QXA6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:TMEM251
gene id: 61622:TMEM251
uniprot id: A0A2K6Q2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

61622:BECN1
gene id: 61622:BECN1
uniprot id: A0A2K6QFX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

61622:PIK3IP1
gene id: 61622:PIK3IP1
uniprot id: A0A2K6QHK4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IL12A
gene id: 61622:IL12A
uniprot id: A0A2K6REW5
uniprot id: A0A2K6REW7
uniprot id: A0A2K6REX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

61622:GBE1
gene id: 61622:GBE1
uniprot id: A0A2K6PB45
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

61622:PPIC
gene id: 61622:PPIC
uniprot id: A0A2K6P8K3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:LNPEP
gene id: 61622:LNPEP
uniprot id: A0A2K6NW04
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:LOC104671185
gene id: 61622:LOC104671185
uniprot id: A0A2K6NGS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

61622:SVOPL
gene id: 61622:SVOPL
uniprot id: A0A2K6QC65
names: Subcellular Location Annotation
messages: Membrane

61622:APOC1
gene id: 61622:APOC1
uniprot id: A0A2K6QV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

61622:PAM
gene id: 61622:PAM
uniprot id: A0A2K6QJY0
uniprot id: A0A2K6QJZ8
uniprot id: A0A2K6QK04
uniprot id: A0A2K6QK17
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

61622:ST6GALNAC6
gene id: 61622:ST6GALNAC6
uniprot id: A0A2K6QBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:MFSD9
gene id: 61622:MFSD9
uniprot id: A0A2K6NGQ2
names: Subcellular Location Annotation
messages: Membrane

61622:RAB3IL1
gene id: 61622:RAB3IL1
uniprot id: A0A2K6NGD4
uniprot id: A0A2K6NGG4
names: Similarity
messages: Belongs to the SEC2 family.

61622:KEG34 p13
gene id: 61622:KEG34_p13
uniprot id: Q15GP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SERPINA10
gene id: 61622:SERPINA10
uniprot id: A0A2K6RGA8
names: Similarity
messages: Belongs to the serpin family.

61622:SERPINA6
gene id: 61622:SERPINA6
uniprot id: A0A2K6R2F6
names: Similarity
messages: Belongs to the serpin family.

61622:HDAC3
gene id: 61622:HDAC3
uniprot id: A0A2K6NRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

61622:UBA3
gene id: 61622:UBA3
uniprot id: A0A2K6Q5X8
uniprot id: A0A2K6Q5Y0
uniprot id: A0A2K6Q5Y4
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

61622:IL2RA
gene id: 61622:IL2RA
uniprot id: A0A2K6PKJ5
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

61622:ALDH1L2
gene id: 61622:ALDH1L2
uniprot id: A0A2K6PWU6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

61622:POT1
gene id: 61622:POT1
uniprot id: A0A2K6RUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

61622:ARL2BP
gene id: 61622:ARL2BP
uniprot id: A0A2K6PEB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

61622:PSMD9
gene id: 61622:PSMD9
uniprot id: A0A2K6RAR5
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

61622:ADAM22
gene id: 61622:ADAM22
uniprot id: A0A2K6P2P1
uniprot id: A0A2K6P2R8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104657697
gene id: 61622:LOC104657697
uniprot id: A0A2K6QFA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

61622:KRT222
gene id: 61622:KRT222
uniprot id: A0A2K6NB10
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PDE3A
gene id: 61622:PDE3A
uniprot id: A0A2K6NWD2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:KIF24
gene id: 61622:KIF24
uniprot id: A0A2K6RG44
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:UGCG
gene id: 61622:UGCG
uniprot id: A0A2K6Q860
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

61622:CDC20B
gene id: 61622:CDC20B
uniprot id: A0A2K6QPR6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

61622:TNFSF14
gene id: 61622:TNFSF14
uniprot id: A0A2K6R7A0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:DPY30
gene id: 61622:DPY30
uniprot id: A0A2K6RH52
names: Similarity
messages: Belongs to the dpy-30 family.

61622:GFOD2
gene id: 61622:GFOD2
uniprot id: A0A2K6RBF1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:RCAN1
gene id: 61622:RCAN1
uniprot id: A0A2K6NWM6
uniprot id: A0A2K6NWP3
names: Similarity
messages: Belongs to the RCAN family.

61622:LMNB1
gene id: 61622:LMNB1
uniprot id: A0A2K6QP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

61622:COL4A3
gene id: 61622:COL4A3
uniprot id: A0A2K6NDV2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:STN1
gene id: 61622:STN1
uniprot id: A0A2K6NGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

61622:SURF6
gene id: 61622:SURF6
uniprot id: A0A2K6NFX6
names: Similarity
messages: Belongs to the SURF6 family.

61622:HAT1
gene id: 61622:HAT1
uniprot id: A0A2K6REU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

61622:IGF2BP3
gene id: 61622:IGF2BP3
uniprot id: A0A2K6Q2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

61622:PGM1
gene id: 61622:PGM1
uniprot id: A0A2K6QSV0
uniprot id: A0A2K6QSV7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61622:VWC2
gene id: 61622:VWC2
uniprot id: A0A2K6QQA4
names: Subcellular Location Annotation
messages: Synapse

61622:FAM49B
gene id: 61622:FAM49B
uniprot id: A0A2K6QBN4
uniprot id: A0A2K6QBQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

61622:SVEP1
gene id: 61622:SVEP1
uniprot id: A0A2K6RCA2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CEBPZ
gene id: 61622:CEBPZ
uniprot id: A0A2K6RUK4
names: Similarity
messages: Belongs to the CBF/MAK21 family.

61622:DTNBP1
gene id: 61622:DTNBP1
uniprot id: A0A2K6PFL4
names: Similarity
messages: Belongs to the dysbindin family.

61622:SELL
gene id: 61622:SELL
uniprot id: A0A2K6PEI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TLR2
gene id: 61622:TLR2
uniprot id: A0A2K6NRU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

61622:KPNA1
gene id: 61622:KPNA1
uniprot id: A0A2K6NKA3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:CAMK2D
gene id: 61622:CAMK2D
uniprot id: A0A2K6N7K6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

61622:EPS8L1
gene id: 61622:EPS8L1
uniprot id: A0A2K6QQ14
names: Similarity
messages: Belongs to the EPS8 family.

61622:FAM227B
gene id: 61622:FAM227B
uniprot id: A0A2K6NEE0
names: Similarity
messages: Belongs to the FAM227 family.

61622:AP1S3
gene id: 61622:AP1S3
uniprot id: A0A2K6PAR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

61622:SF3A3
gene id: 61622:SF3A3
uniprot id: A0A2K6PTM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

61622:SLC35C1
gene id: 61622:SLC35C1
uniprot id: A0A2K6N7Z2
names: Subcellular Location Annotation
messages: Membrane

61622:PLSCR2
gene id: 61622:PLSCR2
uniprot id: A0A2K6PC76
uniprot id: A0A2K6PC80
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:TRMT11
gene id: 61622:TRMT11
uniprot id: A0A2K6R3G1
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

61622:CD164
gene id: 61622:CD164
uniprot id: A0A2K6QCC3
uniprot id: A0A2K6QCD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61622:AKAP8
gene id: 61622:AKAP8
uniprot id: A0A2K6PD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

61622:YPEL4
gene id: 61622:YPEL4
uniprot id: A0A2K6Q1I5
names: Similarity
messages: Belongs to the yippee family.

61622:GC
gene id: 61622:GC
uniprot id: A0A2K6QNP0
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

61622:OPRK1
gene id: 61622:OPRK1
uniprot id: A0A2K6PB58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

61622:LOC104654299
gene id: 61622:LOC104654299
uniprot id: A0A2K6RHP5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:MINDY4
gene id: 61622:MINDY4
uniprot id: A0A2K6R932
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

61622:TOMM7
gene id: 61622:TOMM7
uniprot id: A0A2K6QS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:NLN
gene id: 61622:NLN
uniprot id: A0A2K6Q9Y0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

61622:FOXI2
gene id: 61622:FOXI2
uniprot id: A0A2K6QWD7
names: Subcellular Location Annotation
messages: Nucleus

61622:FAM76A
gene id: 61622:FAM76A
uniprot id: A0A2K6PST8
uniprot id: A0A2K6PST9
names: Similarity
messages: Belongs to the FAM76 family.

61622:GLP2R
gene id: 61622:GLP2R
uniprot id: A0A2K6Q8G1
names: Subcellular Location Annotation
messages: Membrane

61622:CGAS
gene id: 61622:CGAS
uniprot id: A0A2K6R5N6
names: Similarity
messages: Belongs to the mab-21 family.

61622:ABRAXAS1
gene id: 61622:ABRAXAS1
uniprot id: A0A2K6P0J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

61622:DKKL1
gene id: 61622:DKKL1
uniprot id: A0A2K6RJF6
names: Subcellular Location Annotation
messages: Secreted

61622:ELAVL2
gene id: 61622:ELAVL2
uniprot id: A0A2K6R750
names: Similarity
messages: Belongs to the RRM elav family.

61622:DDX43
gene id: 61622:DDX43
uniprot id: A0A2K6PD15
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:BTD
gene id: 61622:BTD
uniprot id: A0A2K6PKA4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61622:CACNB2
gene id: 61622:CACNB2
uniprot id: A0A2K6PBP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

61622:CDH11
gene id: 61622:CDH11
uniprot id: A0A2K6PT09
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:MPDU1
gene id: 61622:MPDU1
uniprot id: A0A2K6QTI5
uniprot id: A0A2K6QTJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

61622:RPL37
gene id: 61622:RPL37
uniprot id: A0A2K6PCK6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:MDGA2
gene id: 61622:MDGA2
uniprot id: A0A2K6NDS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104657953
gene id: 61622:LOC104657953
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:ZPR1
gene id: 61622:ZPR1
uniprot id: A0A2K6N7D1
names: Similarity
messages: Belongs to the ZPR1 family.

61622:TOR2A
gene id: 61622:TOR2A
uniprot id: A0A2K6PJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

61622:TNFRSF10B
gene id: 61622:TNFRSF10B
uniprot id: A0A2K6NKZ4
uniprot id: A0A2K6NL00
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

61622:DGAT1
gene id: 61622:DGAT1
uniprot id: A0A2K6NFA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

61622:ORMDL3
gene id: 61622:ORMDL3
uniprot id: A0A2K6P855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61622:SLFN13
gene id: 61622:SLFN13
uniprot id: A0A2K6NJI0
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

61622:RPS6
gene id: 61622:RPS6
uniprot id: A0A2K6Q9V0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

61622:POLR2L
gene id: 61622:POLR2L
uniprot id: A0A2K6RVG9
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

61622:RETREG1
gene id: 61622:RETREG1
uniprot id: A0A2K6PWK3
uniprot id: A0A2K6PWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NETO1
gene id: 61622:NETO1
uniprot id: A0A2K6Q2Q6
uniprot id: A0A2K6Q2R5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:S1PR1
gene id: 61622:S1PR1
uniprot id: A0A2K6NB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GALNTL6
gene id: 61622:GALNTL6
uniprot id: A0A2K6RHB5
uniprot id: A0A2K6RHC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:POFUT1
gene id: 61622:POFUT1
uniprot id: A0A2K6PK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

61622:CSNK1A1
gene id: 61622:CSNK1A1
uniprot id: A0A2K6PMK1
uniprot id: A0A2K6PMM4
uniprot id: A0A2K6PMT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:B4GALT2
gene id: 61622:B4GALT2
uniprot id: A0A2K6NJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:ANK3
gene id: 61622:ANK3
uniprot id: A0A2K6NDG1
uniprot id: A0A2K6NDH4
uniprot id: A0A2K6NDJ0
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:SETD7
gene id: 61622:SETD7
uniprot id: A0A2K6RCN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

61622:TMEM86B
gene id: 61622:TMEM86B
uniprot id: A0A2K6PQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

61622:NSG1
gene id: 61622:NSG1
uniprot id: A0A2K6NRL7
names: Similarity
messages: Belongs to the NSG family.

61622:IWS1
gene id: 61622:IWS1
uniprot id: A0A2K6NW24
names: Subcellular Location Annotation
messages: Nucleus

61622:SEPHS1
gene id: 61622:SEPHS1
uniprot id: A0A2K6PS31
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

61622:CBX8
gene id: 61622:CBX8
uniprot id: A0A2K6QBY1
names: Subcellular Location Annotation
messages: Nucleus

61622:BROX
gene id: 61622:BROX
uniprot id: A0A2K6R6N7
names: Similarity
messages: Belongs to the BROX family.

61622:PTGFR
gene id: 61622:PTGFR
uniprot id: A0A2K6PE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ATP23
gene id: 61622:ATP23
uniprot id: A0A2K6QER7
names: Similarity
messages: Belongs to the peptidase M76 family.

61622:A3GALT2
gene id: 61622:A3GALT2
uniprot id: A0A2K6Q2P4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

61622:ADD1
gene id: 61622:ADD1
uniprot id: A0A2K6QM38
uniprot id: A0A2K6QM50
uniprot id: A0A2K6QM51
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

61622:RABGGTA
gene id: 61622:RABGGTA
uniprot id: A0A2K6RL64
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

61622:XIAP
gene id: 61622:XIAP
uniprot id: A0A2K6Q6A4
names: Similarity
messages: Belongs to the IAP family.

61622:LOC104667408
gene id: 61622:LOC104667408
uniprot id: A0A2K6Q9P7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

61622:POLR2C
gene id: 61622:POLR2C
uniprot id: A0A2K6RXK9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

61622:FAM114A1
gene id: 61622:FAM114A1
uniprot id: A0A2K6PJJ4
names: Similarity
messages: Belongs to the FAM114 family.

61622:LOC104672245
gene id: 61622:LOC104672245
uniprot id: A0A2K6QAW5
uniprot id: A0A2K6QAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

61622:IZUMO2
gene id: 61622:IZUMO2
uniprot id: A0A2K6QFI7
names: Similarity
messages: Belongs to the Izumo family.

61622:PSEN2
gene id: 61622:PSEN2
uniprot id: A0A2K6PAS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

61622:INCENP
gene id: 61622:INCENP
uniprot id: A0A2K6P749
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

61622:LOC104661016
gene id: 61622:LOC104661016
uniprot id: A0A2K6R024
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:EPHA7
gene id: 61622:EPHA7
uniprot id: A0A2K6PFH6
names: Subcellular Location Annotation
messages: Membrane

61622:LTBR
gene id: 61622:LTBR
uniprot id: A0A2K6R6P4
uniprot id: A0A2K6R6P9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TBR1
gene id: 61622:TBR1
uniprot id: A0A2K6NA61
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:HOXD9
gene id: 61622:HOXD9
uniprot id: A0A2K6PHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:F3
gene id: 61622:F3
uniprot id: A0A2K6NUF3
uniprot id: A0A2K6NUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

61622:LOC104653978
gene id: 61622:LOC104653978
uniprot id: A0A2K6NTS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61622:CACNB3
gene id: 61622:CACNB3
uniprot id: A0A2K6R2H7
uniprot id: A0A2K6R2I8
uniprot id: A0A2K6R2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

61622:PLBD1
gene id: 61622:PLBD1
uniprot id: A0A2K6QW87
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

61622:RAB5IF
gene id: 61622:RAB5IF
uniprot id: A0A2K6RJE0
uniprot id: A0A2K6RJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:AMPD2
gene id: 61622:AMPD2
uniprot id: A0A2K6R8J8
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61622:MAP4K2
gene id: 61622:MAP4K2
uniprot id: A0A2K6R2E4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

61622:CSK
gene id: 61622:CSK
uniprot id: A0A2K6RA36
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:CKS2
gene id: 61622:CKS2
uniprot id: A0A2K6QUX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61622:CXCL14
gene id: 61622:CXCL14
uniprot id: A0A2K6NS67
names: Subcellular Location Annotation
messages: Secreted

61622:ERAL1
gene id: 61622:ERAL1
uniprot id: A0A2K6NRR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

61622:GNG12
gene id: 61622:GNG12
uniprot id: A0A2K6RMD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61622:LOC104654463
gene id: 61622:LOC104654463
uniprot id: A0A2K6NQW7
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:ST3GAL5
gene id: 61622:ST3GAL5
uniprot id: A0A2K6PB34
uniprot id: A0A2K6PB41
uniprot id: A0A2K6PBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:PTPN14
gene id: 61622:PTPN14
uniprot id: A0A2K6Q1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

61622:PTGS1
gene id: 61622:PTGS1
uniprot id: A0A2K6N7W5
uniprot id: A0A2K6N7W7
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CXCL12
gene id: 61622:CXCL12
uniprot id: A0A2K6R281
uniprot id: A0A2K6R283
uniprot id: A0A2K6R2B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:LOC104678448
gene id: 61622:LOC104678448
uniprot id: A0A2K6NHV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

61622:SERPINI1
gene id: 61622:SERPINI1
uniprot id: A0A2K6P4Y2
names: Similarity
messages: Belongs to the serpin family.

61622:NAXD
gene id: 61622:NAXD
uniprot id: A0A2K6RF68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

61622:SNX6
gene id: 61622:SNX6
uniprot id: A0A2K6Q145
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

61622:TATDN1
gene id: 61622:TATDN1
uniprot id: A0A2K6PPM8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61622:LIAS
gene id: 61622:LIAS
uniprot id: A0A2K6REF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

61622:PKD1L2
gene id: 61622:PKD1L2
uniprot id: A0A2K6QJS1
names: Similarity
messages: Belongs to the polycystin family.

61622:RASGRP2
gene id: 61622:RASGRP2
uniprot id: A0A2K6NIB8
names: Similarity
messages: Belongs to the RASGRP family.

61622:SDHAF4
gene id: 61622:SDHAF4
uniprot id: A0A2K6QVX0
names: Similarity
messages: Belongs to the SDHAF4 family.

61622:PPFIBP2
gene id: 61622:PPFIBP2
uniprot id: A0A2K6P8U5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

61622:SPO11
gene id: 61622:SPO11
uniprot id: A0A2K6QUD8
uniprot id: A0A2K6QUG1
names: Similarity
messages: Belongs to the TOP6A family.

61622:YIPF6
gene id: 61622:YIPF6
uniprot id: A0A2K6QJD1
uniprot id: A0A2K6QJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:MYO9A
gene id: 61622:MYO9A
uniprot id: A0A2K6RQH1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:MON1B
gene id: 61622:MON1B
uniprot id: A0A2K6P7L8
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

61622:ESR2
gene id: 61622:ESR2
uniprot id: A0A2K6QUC7
uniprot id: A0A2K6QUG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61622:MRPL9
gene id: 61622:MRPL9
uniprot id: A0A2K6PB53
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

61622:LOC104653588
gene id: 61622:LOC104653588
uniprot id: A0A2K6NB77
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:LCTL
gene id: 61622:LCTL
uniprot id: A0A2K6QZG6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

61622:CNNM1
gene id: 61622:CNNM1
uniprot id: A0A2K6R7M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

61622:TMEM234
gene id: 61622:TMEM234
uniprot id: A0A2K6P6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

61622:MFF
gene id: 61622:MFF
uniprot id: A0A2K6PSZ2
uniprot id: A0A2K6PSZ6
uniprot id: A0A2K6PSZ7
uniprot id: A0A2K6PT03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

61622:TAFA3
gene id: 61622:TAFA3
uniprot id: A0A2K6RMG0
names: Similarity
messages: Belongs to the TAFA family.

61622:TMED2
gene id: 61622:TMED2
uniprot id: A0A2K6R821
uniprot id: A0A2K6R836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61622:B3GAT1
gene id: 61622:B3GAT1
uniprot id: A0A2K6NC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:ADGRG5
gene id: 61622:ADGRG5
uniprot id: A0A2K6PF06
names: Subcellular Location Annotation
messages: Membrane

61622:OSBPL7
gene id: 61622:OSBPL7
uniprot id: A0A2K6NJ54
names: Similarity
messages: Belongs to the OSBP family.

61622:ITPK1
gene id: 61622:ITPK1
uniprot id: A0A2K6RPP9
names: Similarity
messages: Belongs to the ITPK1 family.

61622:CAP1
gene id: 61622:CAP1
uniprot id: A0A2K6QEA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

61622:PRPSAP2
gene id: 61622:PRPSAP2
uniprot id: A0A2K6NKN9
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

61622:POU2F3
gene id: 61622:POU2F3
uniprot id: A0A2K6RUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

61622:KEG34 p10
gene id: 61622:KEG34_p10
uniprot id: Q15GN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SH3GLB1
gene id: 61622:SH3GLB1
uniprot id: A0A2K6NKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

61622:ARMC9
gene id: 61622:ARMC9
uniprot id: A0A2K6PUL4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

61622:GRB7
gene id: 61622:GRB7
uniprot id: A0A2K6P135
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

61622:LOC104675680
gene id: 61622:LOC104675680
uniprot id: A0A2K6Q7Q9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

61622:HOXC13
gene id: 61622:HOXC13
uniprot id: A0A2K6QNT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:ACTC1
gene id: 61622:ACTC1
uniprot id: A0A2K6QJH6
names: Similarity
messages: Belongs to the actin family.

61622:LOC104671316
gene id: 61622:LOC104671316
uniprot id: A0A2K6NK78
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:LOC104671373
gene id: 61622:LOC104671373
uniprot id: A0A2K6NXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

61622:VPS51
gene id: 61622:VPS51
uniprot id: A0A2K6PQF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

61622:MEGF11
gene id: 61622:MEGF11
uniprot id: A0A2K6NQL3
uniprot id: A0A2K6NQM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GRM3
gene id: 61622:GRM3
uniprot id: A0A2K6RVW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

61622:MYO5C
gene id: 61622:MYO5C
uniprot id: A0A2K6RNF1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:NDUFB5
gene id: 61622:NDUFB5
uniprot id: A0A2K6RC66
uniprot id: A0A2K6RC84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:RFX1
gene id: 61622:RFX1
uniprot id: A0A2K6QJ70
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104665273
gene id: 61622:LOC104665273
uniprot id: A0A2K6QRQ6
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:VEGFD
gene id: 61622:VEGFD
uniprot id: A0A2K6P1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

61622:ACOT13
gene id: 61622:ACOT13
uniprot id: A0A2K6P723
names: Similarity
messages: Belongs to the thioesterase PaaI family.

61622:BANF2
gene id: 61622:BANF2
uniprot id: A0A2K6QFQ7
names: Subcellular Location Annotation
messages: Nucleus

61622:SOGA1
gene id: 61622:SOGA1
uniprot id: A0A2K6N993
names: Similarity
messages: Belongs to the SOGA family.

61622:RAD9B
gene id: 61622:RAD9B
uniprot id: A0A2K6P125
uniprot id: A0A2K6P134
names: Similarity
messages: Belongs to the rad9 family.

61622:MMP28
gene id: 61622:MMP28
uniprot id: A0A2K6NZX0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:FA2H
gene id: 61622:FA2H
uniprot id: A0A2K6PNR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NPHS2
gene id: 61622:NPHS2
uniprot id: A0A2K6NMI2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

61622:LOC104678659
gene id: 61622:LOC104678659
uniprot id: A0A2K6NTV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61622:AKT2
gene id: 61622:AKT2
uniprot id: A0A2K6RHX8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

61622:PIP4P2
gene id: 61622:PIP4P2
uniprot id: A0A2K6R340
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

61622:GGPS1
gene id: 61622:GGPS1
uniprot id: A0A2K6PHY0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61622:LOC104663484
gene id: 61622:LOC104663484
uniprot id: A0A2K6NQ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TMC3
gene id: 61622:TMC3
uniprot id: A0A2K6R6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:NDUFA12
gene id: 61622:NDUFA12
uniprot id: A0A2K6PJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:SSTR1
gene id: 61622:SSTR1
uniprot id: A0A2K6QJ25
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PDF
gene id: 61622:PDF
uniprot id: A0A2K6RQL5
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

61622:UNG
gene id: 61622:UNG
uniprot id: A0A2K6R7W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

61622:MYADM
gene id: 61622:MYADM
uniprot id: A0A2K6NR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

61622:BTN2A1
gene id: 61622:BTN2A1
uniprot id: A0A2K6QQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Cytoplasm
messages: Membrane

61622:MEN1
gene id: 61622:MEN1
uniprot id: A0A2K6Q9Z2
uniprot id: A0A2K6QA00
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104682342
gene id: 61622:LOC104682342
uniprot id: A0A2K6NLI9
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:GET3
gene id: 61622:GET3
uniprot id: A0A2K6PUD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

61622:SUMO1
gene id: 61622:SUMO1
uniprot id: A0A2K6Q379
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

61622:SNRPF
gene id: 61622:SNRPF
uniprot id: A0A2K6PAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

61622:ANP32E
gene id: 61622:ANP32E
uniprot id: A0A2K6P4D9
uniprot id: A0A2K6P4F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

61622:HS2ST1
gene id: 61622:HS2ST1
uniprot id: A0A2K6P762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:BMP4
gene id: 61622:BMP4
uniprot id: A0A2K6R7C6
names: Similarity
messages: Belongs to the TGF-beta family.

61622:MATN3
gene id: 61622:MATN3
uniprot id: A0A2K6PQV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MAP7D3
gene id: 61622:MAP7D3
uniprot id: A0A2K6PIB4
names: Similarity
messages: Belongs to the MAP7 family.

61622:LOC104661579
gene id: 61622:LOC104661579
uniprot id: A0A2K6NYI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:KCNA6
gene id: 61622:KCNA6
uniprot id: A0A2K6NMN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:RAPSN
gene id: 61622:RAPSN
uniprot id: A0A2K6QWC4
names: Similarity
messages: Belongs to the RAPsyn family.

61622:CCDC93
gene id: 61622:CCDC93
uniprot id: A0A2K6P966
names: Similarity
messages: Belongs to the CCDC93 family.

61622:NDUFA5
gene id: 61622:NDUFA5
uniprot id: A0A2K6NG68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:STARD6
gene id: 61622:STARD6
uniprot id: A0A2K6P0R6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61622:FAM167A
gene id: 61622:FAM167A
uniprot id: A0A2K6QAH2
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

61622:KRT4
gene id: 61622:KRT4
uniprot id: A0A2K6NCT0
names: Similarity
messages: Belongs to the intermediate filament family.

61622:CD44
gene id: 61622:CD44
uniprot id: A0A2K6R1G5
uniprot id: A0A2K6R1G8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

61622:LGSN
gene id: 61622:LGSN
uniprot id: A0A2K6RJQ4
names: Similarity
messages: Belongs to the glutamine synthetase family.

61622:GDAP2
gene id: 61622:GDAP2
uniprot id: A0A2K6RMI7
names: Similarity
messages: Belongs to the GDAP2 family.

61622:GBX2
gene id: 61622:GBX2
uniprot id: A0A2K6Q194
names: Subcellular Location Annotation
messages: Nucleus

61622:RENBP
gene id: 61622:RENBP
uniprot id: A0A2K6PV22
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

61622:SPACA5
gene id: 61622:SPACA5
uniprot id: A0A2K6PJ45
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

61622:GSTO1
gene id: 61622:GSTO1
uniprot id: A0A2K6PFI7
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

61622:BMP10
gene id: 61622:BMP10
uniprot id: A0A2K6QU18
names: Similarity
messages: Belongs to the TGF-beta family.

61622:CTBS
gene id: 61622:CTBS
uniprot id: A0A2K6NTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

61622:ARSH
gene id: 61622:ARSH
uniprot id: A0A2K6QRK3
names: Similarity
messages: Belongs to the sulfatase family.

61622:CAMP
gene id: 61622:CAMP
uniprot id: A0A2K6RID8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (By similarity). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (By similarity). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro).
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Monomer, homodimer or homotrimer (in vitro) (By similarity). Oligomerizes as tetra- or hexamer in solution (in vitro).
messages: Secreted
messages: Vesicle

61622:SIRT5
gene id: 61622:SIRT5
uniprot id: A0A2K6PGP2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

61622:PDS5A
gene id: 61622:PDS5A
uniprot id: A0A2K6QD87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

61622:CARMIL1
gene id: 61622:CARMIL1
uniprot id: A0A2K6RE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

61622:COPZ1
gene id: 61622:COPZ1
uniprot id: A0A2K6P0E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

61622:LOC104655673
gene id: 61622:LOC104655673
uniprot id: A0A2K6PAX9
names: Subcellular Location Annotation
messages: Membrane

61622:REEP2
gene id: 61622:REEP2
uniprot id: A0A2K6PFW9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GPM6A
gene id: 61622:GPM6A
uniprot id: A0A2K6P5G1
uniprot id: A0A2K6P5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61622:PLCG1
gene id: 61622:PLCG1
uniprot id: A0A2K6Q7Y9
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

61622:KRT14
gene id: 61622:KRT14
uniprot id: A0A2K6Q1E0
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SLCO4C1
gene id: 61622:SLCO4C1
uniprot id: A0A2K6QB18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61622:THOC5
gene id: 61622:THOC5
uniprot id: A0A2K6NZX3
uniprot id: A0A2K6P004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

61622:ATP6AP1
gene id: 61622:ATP6AP1
uniprot id: A0A2K6NRT4
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

61622:DMTN
gene id: 61622:DMTN
uniprot id: A0A2K6RE84
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PIK3C3
gene id: 61622:PIK3C3
uniprot id: A0A2K6QT19
uniprot id: A0A2K6QT22
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:GDPD3
gene id: 61622:GDPD3
uniprot id: A0A2K6QK24
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:CD55
gene id: 61622:CD55
uniprot id: A0A2K6NWQ7
uniprot id: A0A2K6NWR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CSTF3
gene id: 61622:CSTF3
uniprot id: A0A2K6RHG3
names: Subcellular Location Annotation
messages: Nucleus

61622:NEURL2
gene id: 61622:NEURL2
uniprot id: A0A2K6NQR2
names: Subcellular Location Annotation
messages: Cytoplasm

61622:MFN1
gene id: 61622:MFN1
uniprot id: A0A2K6NHN8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

61622:PFKFB3
gene id: 61622:PFKFB3
uniprot id: A0A2K6QAL5
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61622:SLC12A6
gene id: 61622:SLC12A6
uniprot id: A0A2K6PIX9
uniprot id: A0A2K6PIZ1
uniprot id: A0A2K6PJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:MYB
gene id: 61622:MYB
uniprot id: A0A2K6QNL9
uniprot id: A0A2K6QNN4
names: Subcellular Location Annotation
messages: Nucleus

61622:CMPK2
gene id: 61622:CMPK2
uniprot id: A0A2K6NPN4
names: Similarity
messages: Belongs to the thymidylate kinase family.

61622:TTC21B
gene id: 61622:TTC21B
uniprot id: A0A2K6PK51
names: Similarity
messages: Belongs to the TTC21 family.

61622:CDC6
gene id: 61622:CDC6
uniprot id: A0A2K6R0U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

61622:VAMP2
gene id: 61622:VAMP2
uniprot id: A0A2K6P5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:LOC104673294
gene id: 61622:LOC104673294
uniprot id: A0A2K6QW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

61622:PFDN1
gene id: 61622:PFDN1
uniprot id: A0A2K6QWC5
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61622:CCR9
gene id: 61622:CCR9
uniprot id: A0A2K6QI53
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:CHAC1
gene id: 61622:CHAC1
uniprot id: A0A2K6NP21
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

61622:MARS2
gene id: 61622:MARS2
uniprot id: A0A2K6NFV5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:CRISP2
gene id: 61622:CRISP2
uniprot id: A0A2K6NL30
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HNRNPAB
gene id: 61622:HNRNPAB
uniprot id: A0A2K6Q4U9
uniprot id: A0A2K6Q4V3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:ZNF287
gene id: 61622:ZNF287
uniprot id: A0A2K6QAA6
names: Subcellular Location Annotation
messages: Nucleus

61622:TNPO1
gene id: 61622:TNPO1
uniprot id: A0A2K6Q291
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LOC104670020
gene id: 61622:LOC104670020
uniprot id: A0A2K6RT88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61622:HIF1A
gene id: 61622:HIF1A
uniprot id: A0A2K6N891
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

61622:RPL29
gene id: 61622:RPL29
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:TSPAN2
gene id: 61622:TSPAN2
uniprot id: A0A2K6PNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:PFDN4
gene id: 61622:PFDN4
uniprot id: A0A2K6PBH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

61622:ALDH2
gene id: 61622:ALDH2
uniprot id: A0A2K6NRB9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:PRICKLE3
gene id: 61622:PRICKLE3
uniprot id: A0A2K6Q742
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61622:LOC104677846
gene id: 61622:LOC104677846
uniprot id: A0A2K6R7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

61622:OSBPL9
gene id: 61622:OSBPL9
uniprot id: A0A2K6RQT4
uniprot id: A0A2K6RQW6
uniprot id: A0A2K6RQX3
names: Similarity
messages: Belongs to the OSBP family.

61622:ZSCAN12
gene id: 61622:ZSCAN12
uniprot id: A0A2K6RW34
names: Subcellular Location Annotation
messages: Nucleus

61622:DYRK1B
gene id: 61622:DYRK1B
uniprot id: A0A2K6Q6G0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

61622:PEX2
gene id: 61622:PEX2
uniprot id: A0A2K6NI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

61622:RRP36
gene id: 61622:RRP36
uniprot id: A0A2K6QZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

61622:PLBD2
gene id: 61622:PLBD2
uniprot id: A0A2K6PP87
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

61622:OTUB1
gene id: 61622:OTUB1
uniprot id: A0A2K6R774
names: Similarity
messages: Belongs to the peptidase C65 family.

61622:TMEM59L
gene id: 61622:TMEM59L
uniprot id: A0A2K6NNS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:RPS12
gene id: 61622:RPS12
uniprot id: A0A2K6PUZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

61622:SLC27A1
gene id: 61622:SLC27A1
uniprot id: A0A2K6PWL9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:RAB3GAP1
gene id: 61622:RAB3GAP1
uniprot id: A0A2K6PQX1
uniprot id: A0A2K6PQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

61622:ANXA9
gene id: 61622:ANXA9
uniprot id: A0A2K6PLB4
uniprot id: A0A2K6PLJ1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61622:MSX2
gene id: 61622:MSX2
uniprot id: A0A2K6QC61
names: Subcellular Location Annotation
messages: Nucleus

61622:KIAA2013
gene id: 61622:KIAA2013
uniprot id: A0A2K6QIX5
names: Subcellular Location Annotation
messages: Membrane

61622:UGT3A2
gene id: 61622:UGT3A2
uniprot id: A0A2K6P7X5
uniprot id: A0A2K6P7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:METTL2A
gene id: 61622:METTL2A
uniprot id: A0A2K6PS64
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

61622:EPN3
gene id: 61622:EPN3
uniprot id: A0A2K6RD74
names: Similarity
messages: Belongs to the epsin family.

61622:ENTPD2
gene id: 61622:ENTPD2
uniprot id: A0A2K6QYH7
uniprot id: A0A2K6QYJ6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:GSX1
gene id: 61622:GSX1
uniprot id: A0A2K6PIN4
names: Subcellular Location Annotation
messages: Nucleus

61622:ATP1A2
gene id: 61622:ATP1A2
uniprot id: A0A2K6PQU8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:HTATSF1
gene id: 61622:HTATSF1
uniprot id: A0A2K6NM05
names: Similarity
messages: Belongs to the HTATSF1 family.

61622:ALOX15B
gene id: 61622:ALOX15B
uniprot id: A0A2K6QS66
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DMRT1
gene id: 61622:DMRT1
uniprot id: A0A2K6Q147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:PFAS
gene id: 61622:PFAS
uniprot id: A0A2K6RPV4
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

61622:HMGB3
gene id: 61622:HMGB3
uniprot id: A0A2K6NHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:TBC1D7
gene id: 61622:TBC1D7
uniprot id: A0A2K6QVL7
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

61622:TGM1
gene id: 61622:TGM1
uniprot id: A0A2K6RWX5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:MRPS14
gene id: 61622:MRPS14
uniprot id: A0A2K6RLY3
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

61622:AVPR1B
gene id: 61622:AVPR1B
uniprot id: A0A2K6QM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

61622:CDKN3
gene id: 61622:CDKN3
uniprot id: A0A2K6PYA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

61622:RPL13
gene id: 61622:RPL13
uniprot id: A0A2K6QCL1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

61622:MMP20
gene id: 61622:MMP20
uniprot id: A0A2K6QL72
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

61622:TM6SF1
gene id: 61622:TM6SF1
uniprot id: A0A2K6RST8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

61622:GOSR1
gene id: 61622:GOSR1
uniprot id: A0A2K6PX71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

61622:CENPE
gene id: 61622:CENPE
uniprot id: A0A2K6NW65
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:SNTB1
gene id: 61622:SNTB1
uniprot id: A0A2K6R0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

61622:CERT1
gene id: 61622:CERT1
uniprot id: A0A2K6P288
uniprot id: A0A2K6P293
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

61622:NR1H3
gene id: 61622:NR1H3
uniprot id: A0A2K6RWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:PTPRZ1
gene id: 61622:PTPRZ1
uniprot id: A0A2K6NIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61622:HINT1
gene id: 61622:HINT1
uniprot id: A0A2K6NPK6
names: Similarity
messages: Belongs to the HINT family.

61622:RIOK2
gene id: 61622:RIOK2
uniprot id: A0A2K6QQC2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

61622:SLC35A1
gene id: 61622:SLC35A1
uniprot id: A0A2K6PZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104679032
gene id: 61622:LOC104679032
uniprot id: A0A2K6QUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

61622:GRIN2A
gene id: 61622:GRIN2A
uniprot id: A0A2K6RR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:SLC9A1
gene id: 61622:SLC9A1
uniprot id: A0A2K6Q2N7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61622:ENTPD3
gene id: 61622:ENTPD3
uniprot id: A0A2K6P796
uniprot id: A0A2K6P7C4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:RC3H2
gene id: 61622:RC3H2
uniprot id: A0A2K6RJI4
names: Subcellular Location Annotation
messages: P-body

61622:ADCY4
gene id: 61622:ADCY4
uniprot id: A0A2K6N9Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

61622:RO60
gene id: 61622:RO60
uniprot id: A0A2K6PWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

61622:STX3
gene id: 61622:STX3
uniprot id: A0A2K6R9S6
uniprot id: A0A2K6R9S7
names: Similarity
messages: Belongs to the syntaxin family.

61622:SLC30A8
gene id: 61622:SLC30A8
uniprot id: A0A2K6R9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:CDC42EP3
gene id: 61622:CDC42EP3
uniprot id: A0A2K6QBJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

61622:CCSER2
gene id: 61622:CCSER2
uniprot id: A0A2K6RJC2
names: Similarity
messages: Belongs to the CCSER family.

61622:EMC1
gene id: 61622:EMC1
uniprot id: A0A2K6Q6D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104677990
gene id: 61622:LOC104677990
uniprot id: A0A2K6NR28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

61622:KIF23
gene id: 61622:KIF23
uniprot id: A0A2K6NFV2
uniprot id: A0A2K6NFV4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:LOC104680098
gene id: 61622:LOC104680098
uniprot id: A0A2K6PKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

61622:TNFRSF8
gene id: 61622:TNFRSF8
uniprot id: A0A2K6R1C2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DDX21
gene id: 61622:DDX21
uniprot id: A0A2K6PQ84
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

61622:HEXIM2
gene id: 61622:HEXIM2
uniprot id: A0A2K6R7Y3
uniprot id: A0A2K6R7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

61622:SLU7
gene id: 61622:SLU7
uniprot id: A0A2K6ND67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

61622:VPS53
gene id: 61622:VPS53
uniprot id: A0A2K6RIA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

61622:ABCC9
gene id: 61622:ABCC9
uniprot id: A0A2K6QP55
uniprot id: A0A2K6QP82
uniprot id: A0A2K6QP84
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

61622:TAF9B
gene id: 61622:TAF9B
uniprot id: A0A2K6PGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61622:STX1B
gene id: 61622:STX1B
uniprot id: A0A2K6PWC8
names: Similarity
messages: Belongs to the syntaxin family.

61622:GLYR1
gene id: 61622:GLYR1
uniprot id: A0A2K6NX87
uniprot id: A0A2K6NX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

61622:SLC25A30
gene id: 61622:SLC25A30
uniprot id: A0A2K6PL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:MFSD4A
gene id: 61622:MFSD4A
uniprot id: A0A2K6PNR7
names: Subcellular Location Annotation
messages: Membrane

61622:PDP2
gene id: 61622:PDP2
uniprot id: A0A2K6ND41
names: Similarity
messages: Belongs to the PP2C family.

61622:KPNA4
gene id: 61622:KPNA4
uniprot id: A0A2K6NFI8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:SEC22B
gene id: 61622:SEC22B
uniprot id: A0A2K6RH46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

61622:LOC104670860
gene id: 61622:LOC104670860
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ATP1B3
gene id: 61622:ATP1B3
uniprot id: A0A2K6P7K1
uniprot id: A0A2K6P7Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61622:NR4A2
gene id: 61622:NR4A2
uniprot id: A0A2K6PYV4
uniprot id: A0A2K6PYV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

61622:MYH8
gene id: 61622:MYH8
uniprot id: A0A2K6RTT7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:SH2B1
gene id: 61622:SH2B1
uniprot id: A0A2K6NYR6
names: Similarity
messages: Belongs to the SH2B adapter family.

61622:CDCA2
gene id: 61622:CDCA2
uniprot id: A0A2K6Q469
names: Subcellular Location Annotation
messages: Nucleus

61622:PPP1R2
gene id: 61622:PPP1R2
uniprot id: A0A2K6NVD3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

61622:DDX1
gene id: 61622:DDX1
uniprot id: A0A2K6PBQ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

61622:MTRF1
gene id: 61622:MTRF1
uniprot id: A0A2K6Q2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

61622:BGN
gene id: 61622:BGN
uniprot id: A0A2K6R9R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

61622:TMEM126A
gene id: 61622:TMEM126A
uniprot id: A0A2K6NUF2
names: Subcellular Location Annotation
messages: Membrane

61622:SUGP2
gene id: 61622:SUGP2
uniprot id: A0A2K6NZG4
names: Subcellular Location Annotation
messages: Nucleus

61622:GPLD1
gene id: 61622:GPLD1
uniprot id: A0A2K6PZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

61622:SARS2
gene id: 61622:SARS2
uniprot id: A0A2K6PHJ1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

61622:KCTD11
gene id: 61622:KCTD11
uniprot id: A0A2K6NBP8
names: Subcellular Location Annotation
messages: Cell membrane

61622:CDH22
gene id: 61622:CDH22
uniprot id: A0A2K6QLG4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:DPEP3
gene id: 61622:DPEP3
uniprot id: A0A2K6P2X6
names: Subcellular Location Annotation
messages: Membrane

61622:AP2S1
gene id: 61622:AP2S1
uniprot id: A0A2K6RVK8
uniprot id: A0A2K6RVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

61622:NDRG4
gene id: 61622:NDRG4
uniprot id: A0A2K6QH32
uniprot id: A0A2K6QH38
uniprot id: A0A2K6QH41
uniprot id: A0A2K6QH57
uniprot id: A0A2K6QH62
names: Similarity
messages: Belongs to the NDRG family.

61622:HOXC11
gene id: 61622:HOXC11
uniprot id: A0A2K6RV82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:PPIL1
gene id: 61622:PPIL1
uniprot id: A0A2K6RUA0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:MS4A1
gene id: 61622:MS4A1
uniprot id: A0A2K6REK5
names: Similarity
messages: Belongs to the MS4A family.

61622:TBXAS1
gene id: 61622:TBXAS1
uniprot id: A0A2K6QQQ1
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:TMEM132B
gene id: 61622:TMEM132B
uniprot id: A0A2K6PUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61622:EIF5B
gene id: 61622:EIF5B
uniprot id: A0A2K6QMZ0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

61622:YWHAB
gene id: 61622:YWHAB
uniprot id: A0A2K6PG93
names: Similarity
messages: Belongs to the 14-3-3 family.

61622:KIFBP
gene id: 61622:KIFBP
uniprot id: A0A2K6Q8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

61622:CFDP1
gene id: 61622:CFDP1
uniprot id: A0A2K6QZX0
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

61622:MMP14
gene id: 61622:MMP14
uniprot id: A0A2K6PH70
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

61622:NKAP
gene id: 61622:NKAP
uniprot id: A0A2K6RJG9
names: Similarity
messages: Belongs to the NKAP family.

61622:NARF
gene id: 61622:NARF
uniprot id: A0A2K6NF76
names: Similarity
messages: Belongs to the NARF family.

61622:NT5E
gene id: 61622:NT5E
uniprot id: A0A2K6NWJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

61622:ARV1
gene id: 61622:ARV1
uniprot id: A0A2K6PAJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

61622:NLE1
gene id: 61622:NLE1
uniprot id: A0A2K6QQG7
names: Subcellular Location Annotation
messages: nucleolus

61622:LOC104661665
gene id: 61622:LOC104661665
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LRRFIP2
gene id: 61622:LRRFIP2
uniprot id: A0A2K6PLC5
names: Similarity
messages: Belongs to the LRRFIP family.

61622:PRTFDC1
gene id: 61622:PRTFDC1
uniprot id: A0A2K6QBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

61622:CCDC58
gene id: 61622:CCDC58
uniprot id: A0A2K6RVX7
names: Similarity
messages: Belongs to the MIX23 family.

61622:HTR1B
gene id: 61622:HTR1B
uniprot id: A0A2K6NJ45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

61622:PDP1
gene id: 61622:PDP1
uniprot id: A0A2K6PT58
names: Similarity
messages: Belongs to the PP2C family.

61622:POLR2E
gene id: 61622:POLR2E
uniprot id: A0A2K6RJA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

61622:RIPPLY2
gene id: 61622:RIPPLY2
uniprot id: A0A2K6N6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

61622:ATG16L2
gene id: 61622:ATG16L2
uniprot id: A0A2K6NNX6
uniprot id: A0A2K6NNY1
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

61622:RPS11
gene id: 61622:RPS11
uniprot id: A0A2K6RW45
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

61622:S100A6
gene id: 61622:S100A6
uniprot id: A0A2K6NAE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

61622:IGFBP2
gene id: 61622:IGFBP2
uniprot id: A0A2K6N8C6
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:FAM92A
gene id: 61622:FAM92A
uniprot id: A0A2K6P9B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

61622:TARBP2
gene id: 61622:TARBP2
uniprot id: A0A2K6RR16
uniprot id: A0A2K6RR32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

61622:PRPS2
gene id: 61622:PRPS2
uniprot id: A0A2K6P908
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

61622:SLC5A12
gene id: 61622:SLC5A12
uniprot id: A0A2K6NH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

61622:SERPINC1
gene id: 61622:SERPINC1
uniprot id: A0A2K6Q958
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

61622:AACS
gene id: 61622:AACS
uniprot id: A0A2K6P8V2
uniprot id: A0A2K6P8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

61622:TAC3
gene id: 61622:TAC3
uniprot id: A0A2K6RKX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

61622:INSL5
gene id: 61622:INSL5
uniprot id: A0A2K6QAP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

61622:GALNT15
gene id: 61622:GALNT15
uniprot id: A0A2K6QI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:CASP1
gene id: 61622:CASP1
uniprot id: A0A2K6R910
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:NEU1
gene id: 61622:NEU1
uniprot id: A0A2K6NNN9
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:LAMTOR1
gene id: 61622:LAMTOR1
uniprot id: A0A2K6RK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

61622:STMN4
gene id: 61622:STMN4
uniprot id: A0A2K6RD51
uniprot id: A0A2K6RD61
uniprot id: A0A2K6RD90
names: Similarity
messages: Belongs to the stathmin family.

61622:RMI1
gene id: 61622:RMI1
uniprot id: A0A2K6QEC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

61622:CUL9
gene id: 61622:CUL9
uniprot id: A0A2K6PZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

61622:LOC104662944
gene id: 61622:LOC104662944
uniprot id: A0A2K6RP00
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61622:CLDN19
gene id: 61622:CLDN19
uniprot id: A0A2K6R4K2
uniprot id: A0A2K6R4L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:PARP6
gene id: 61622:PARP6
uniprot id: A0A2K6QLA7
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:ZGPAT
gene id: 61622:ZGPAT
uniprot id: A0A2K6QPN7
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

61622:PRDM1
gene id: 61622:PRDM1
uniprot id: A0A2K6PMY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

61622:GRAMD1B
gene id: 61622:GRAMD1B
uniprot id: A0A2K6RHL1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:METAP2
gene id: 61622:METAP2
uniprot id: A0A2K6P5Z4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

61622:TMEM183A
gene id: 61622:TMEM183A
uniprot id: A0A2K6QVX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

61622:TLL2
gene id: 61622:TLL2
uniprot id: A0A2K6NF87
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CEP63
gene id: 61622:CEP63
uniprot id: A0A2K6RHV0
uniprot id: A0A2K6RHZ4
uniprot id: A0A2K6RHZ9
names: Similarity
messages: Belongs to the CEP63 family.

61622:KCNRG
gene id: 61622:KCNRG
uniprot id: A0A2K6Q7V3
names: Subcellular Location Annotation
messages: Cell membrane

61622:GASK1A
gene id: 61622:GASK1A
uniprot id: A0A2K6R2E9
uniprot id: A0A2K6R2I4
names: Similarity
messages: Belongs to the GASK family.

61622:TRAF6
gene id: 61622:TRAF6
uniprot id: A0A2K6RDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

61622:RAB3IP
gene id: 61622:RAB3IP
uniprot id: A0A2K6P731
uniprot id: A0A2K6P740
uniprot id: A0A2K6P746
names: Similarity
messages: Belongs to the SEC2 family.

61622:CREG1
gene id: 61622:CREG1
uniprot id: A0A2K6P9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

61622:BRINP2
gene id: 61622:BRINP2
uniprot id: A0A2K6RMF1
names: Similarity
messages: Belongs to the BRINP family.

61622:ALPI
gene id: 61622:ALPI
uniprot id: A0A2K6NZB7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

61622:ALAS2
gene id: 61622:ALAS2
uniprot id: A0A2K6PVC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

61622:TMEM123
gene id: 61622:TMEM123
uniprot id: A0A2K6Q1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61622:LIX1
gene id: 61622:LIX1
uniprot id: A0A2K6Q0J7
names: Similarity
messages: Belongs to the LIX1 family.

61622:CNOT11
gene id: 61622:CNOT11
uniprot id: A0A2K6PNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

61622:BCAR1
gene id: 61622:BCAR1
uniprot id: A0A2K6PGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:GALE
gene id: 61622:GALE
uniprot id: A0A2K6RC44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

61622:MED27
gene id: 61622:MED27
uniprot id: A0A2K6QCG2
uniprot id: A0A2K6QCJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:MON2
gene id: 61622:MON2
uniprot id: A0A2K6RAV2
uniprot id: A0A2K6RAW7
names: Similarity
messages: Belongs to the MON2 family.

61622:DYNC1LI2
gene id: 61622:DYNC1LI2
uniprot id: A0A2K6QFU4
uniprot id: A0A2K6QFX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

61622:TEX13A
gene id: 61622:TEX13A
uniprot id: A0A2K6QZW7
names: Similarity
messages: Belongs to the TEX13 family.

61622:AOC2
gene id: 61622:AOC2
uniprot id: A0A2K6NN55
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

61622:PURB
gene id: 61622:PURB
uniprot id: A0A2K6N729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

61622:TNFRSF9
gene id: 61622:TNFRSF9
uniprot id: A0A2K6R295
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SLC7A1
gene id: 61622:SLC7A1
uniprot id: A0A2K6Q631
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

61622:CLUAP1
gene id: 61622:CLUAP1
uniprot id: A0A2K6P1J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

61622:NPC2
gene id: 61622:NPC2
uniprot id: A0A2K6QHT4
uniprot id: A0A2K6QHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

61622:C17H8orf33
gene id: 61622:C17H8orf33
uniprot id: A0A2K6QLL5
names: Similarity
messages: Belongs to the UPF0488 family.

61622:SH3BP5L
gene id: 61622:SH3BP5L
uniprot id: A0A2K6RVG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

61622:KCNB2
gene id: 61622:KCNB2
uniprot id: A0A2K6NUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: dendrite

61622:ATP5MD
gene id: 61622:ATP5MD
uniprot id: A0A2K6RJF5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

61622:GRIK5
gene id: 61622:GRIK5
uniprot id: A0A2K6NN19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:LOC104657598
gene id: 61622:LOC104657598
uniprot id: A0A2K6P6P9
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

61622:ATP2C2
gene id: 61622:ATP2C2
uniprot id: A0A2K6P0T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TNF
gene id: 61622:TNF
uniprot id: A0A2K6NLU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.

61622:SRP72
gene id: 61622:SRP72
uniprot id: A0A2K6Q4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

61622:LOC104669505
gene id: 61622:LOC104669505
uniprot id: A0A2K6PDC6
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

61622:NIPBL
gene id: 61622:NIPBL
uniprot id: A0A2K6NTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

61622:SLC46A1
gene id: 61622:SLC46A1
uniprot id: A0A2K6QAC6
names: Subcellular Location Annotation
messages: Membrane

61622:C15H11orf54
gene id: 61622:C15H11orf54
uniprot id: A0A2K6QKJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

61622:LOC104656020
gene id: 61622:LOC104656020
uniprot id: A0A2K6QSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

61622:RTN1
gene id: 61622:RTN1
uniprot id: A0A2K6R616
uniprot id: A0A2K6R618
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TMEM198
gene id: 61622:TMEM198
uniprot id: A0A2K6NJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

61622:PACC1
gene id: 61622:PACC1
uniprot id: A0A2K6PSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

61622:MVD
gene id: 61622:MVD
uniprot id: A0A2K6PZ43
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

61622:TNFSF9
gene id: 61622:TNFSF9
uniprot id: A0A2K6RHM3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:DSG3
gene id: 61622:DSG3
uniprot id: A0A2K6PLG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

61622:ALDH16A1
gene id: 61622:ALDH16A1
uniprot id: A0A2K6RQR0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Interacts with SPG21.

61622:MRAP2
gene id: 61622:MRAP2
uniprot id: A0A2K6R6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LLGL2
gene id: 61622:LLGL2
uniprot id: A0A2K6RPR9
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

61622:GAPVD1
gene id: 61622:GAPVD1
uniprot id: A0A2K6PM72
uniprot id: A0A2K6PM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

61622:DPYSL2
gene id: 61622:DPYSL2
uniprot id: A0A2K6R141
uniprot id: A0A2K6R150
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

61622:PAMR1
gene id: 61622:PAMR1
uniprot id: A0A2K6NVI1
uniprot id: A0A2K6NVI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:AARS1
gene id: 61622:AARS1
uniprot id: A0A2K6NSV0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

61622:CHMP2A
gene id: 61622:CHMP2A
uniprot id: A0A2K6P0Y5
names: Similarity
messages: Belongs to the SNF7 family.

61622:POMGNT2
gene id: 61622:POMGNT2
uniprot id: A0A2K6NE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NSUN5
gene id: 61622:NSUN5
uniprot id: A0A2K6R7E1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61622:SLC25A29
gene id: 61622:SLC25A29
uniprot id: A0A2K6QME7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:USP10
gene id: 61622:USP10
uniprot id: A0A2K6NB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:NAPG
gene id: 61622:NAPG
uniprot id: A0A2K6RNN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

61622:LOC104673107
gene id: 61622:LOC104673107
uniprot id: A0A2K6NSU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ATP6V1G3
gene id: 61622:ATP6V1G3
uniprot id: A0A2K6PM60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:PDCL3
gene id: 61622:PDCL3
uniprot id: A0A2K6Q189
names: Similarity
messages: Belongs to the phosducin family.

61622:HTR3A
gene id: 61622:HTR3A
uniprot id: A0A2K6Q461
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane

61622:PC
gene id: 61622:PC
uniprot id: A0A2K6NY42
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

61622:TRIM56
gene id: 61622:TRIM56
uniprot id: A0A2K6NNE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

61622:TG
gene id: 61622:TG
uniprot id: A0A2K6QLW2
names: Caution
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104654993
gene id: 61622:LOC104654993
uniprot id: A0A2K6PYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104674527
gene id: 61622:LOC104674527
uniprot id: A0A2K6NNV5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TMEM214
gene id: 61622:TMEM214
uniprot id: A0A2K6NVA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ROPN1L
gene id: 61622:ROPN1L
uniprot id: A0A2K6QL26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

61622:TTC4
gene id: 61622:TTC4
uniprot id: A0A2K6RTI7
names: Similarity
messages: Belongs to the TTC4 family.

61622:TBX15
gene id: 61622:TBX15
uniprot id: A0A2K6QPS5
uniprot id: A0A2K6QPU5
uniprot id: A0A2K6QPU8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:ORM1
gene id: 61622:ORM1
uniprot id: A0A2K6RC52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

61622:NOL10
gene id: 61622:NOL10
uniprot id: A0A2K6RFP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

61622:PSMF1
gene id: 61622:PSMF1
uniprot id: A0A2K6QM85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

61622:LOC104679831
gene id: 61622:LOC104679831
uniprot id: A0A2K6QGT0
names: Subunit
messages: Monomer.

61622:LOC104674933
gene id: 61622:LOC104674933
uniprot id: A0A2K6NKK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LY6D
gene id: 61622:LY6D
uniprot id: A0A2K6RKA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TRIM32
gene id: 61622:TRIM32
uniprot id: A0A2K6NNF2
names: Similarity
messages: Belongs to the TRIM/RBCC family.

61622:PPARG
gene id: 61622:PPARG
uniprot id: A0A2K6RRF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

61622:SV2A
gene id: 61622:SV2A
uniprot id: A0A2K6P776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

61622:MYOF
gene id: 61622:MYOF
uniprot id: A0A2K6P7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61622:LOC104682148
gene id: 61622:LOC104682148
uniprot id: A0A2K6RIJ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61622:PPP2R5A
gene id: 61622:PPP2R5A
uniprot id: A0A2K6NQ77
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:EHD1
gene id: 61622:EHD1
uniprot id: A0A2K6NR76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

61622:LOC104674154
gene id: 61622:LOC104674154
uniprot id: A0A2K6RW35
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:UBA5
gene id: 61622:UBA5
uniprot id: A0A2K6NFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

61622:TDRD7
gene id: 61622:TDRD7
uniprot id: A0A2K6Q598
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

61622:ALG11
gene id: 61622:ALG11
uniprot id: A0A2K6QNW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

61622:RRP1B
gene id: 61622:RRP1B
uniprot id: A0A2K6PDQ0
names: Similarity
messages: Belongs to the RRP1 family.

61622:CIAO2A
gene id: 61622:CIAO2A
uniprot id: A0A2K6PE14
uniprot id: A0A2K6PE31
names: Similarity
messages: Belongs to the MIP18 family.

61622:PPIH
gene id: 61622:PPIH
uniprot id: A0A2K6RLZ4
uniprot id: A0A2K6RLZ5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:LOC104656604
gene id: 61622:LOC104656604
uniprot id: A0A2K6RRE4
uniprot id: A0A2K6RRF1
names: Similarity
messages: Belongs to the Luc7 family.

61622:TMEM132A
gene id: 61622:TMEM132A
uniprot id: A0A2K6QQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61622:LYPLA2
gene id: 61622:LYPLA2
uniprot id: A0A2K6P7Z0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

61622:TRIM36
gene id: 61622:TRIM36
uniprot id: A0A2K6QYR1
uniprot id: A0A2K6QYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

61622:MRPS27
gene id: 61622:MRPS27
uniprot id: A0A2K6QZ18
names: Subcellular Location Annotation
messages: Mitochondrion

61622:LOC104658905
gene id: 61622:LOC104658905
uniprot id: A0A2K6NCQ3
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:EXT2
gene id: 61622:EXT2
uniprot id: A0A2K6RMJ4
uniprot id: A0A2K6RMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ABCB4
gene id: 61622:ABCB4
uniprot id: A0A2K6Q9S7
names: Subcellular Location Annotation
messages: Membrane

61622:B3GALT5
gene id: 61622:B3GALT5
uniprot id: A0A2K6NYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:CD34
gene id: 61622:CD34
uniprot id: A0A2K6NFQ9
uniprot id: A0A2K6NFR2
names: Subcellular Location Annotation
messages: Membrane

61622:CA3
gene id: 61622:CA3
uniprot id: A0A2K6N817
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:HMOX2
gene id: 61622:HMOX2
uniprot id: A0A2K6N8F6
names: Similarity
messages: Belongs to the heme oxygenase family.

61622:DVL2
gene id: 61622:DVL2
uniprot id: A0A2K6PSZ4
names: Similarity
messages: Belongs to the DSH family.

61622:DOT1L
gene id: 61622:DOT1L
uniprot id: A0A2K6RSM2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Histone methyltransferase. Methylates 'Lys-79' of histone H3.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

61622:PMPCA
gene id: 61622:PMPCA
uniprot id: A0A2K6QIJ2
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:TENT5B
gene id: 61622:TENT5B
uniprot id: A0A2K6RVE0
names: Similarity
messages: Belongs to the TENT family.

61622:AGO1
gene id: 61622:AGO1
uniprot id: A0A2K6RP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

61622:CNOT7
gene id: 61622:CNOT7
uniprot id: A0A2K6PY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

61622:TRAM1L1
gene id: 61622:TRAM1L1
uniprot id: A0A2K6NA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61622:VAPB
gene id: 61622:VAPB
uniprot id: A0A2K6Q1Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CHGB
gene id: 61622:CHGB
uniprot id: A0A2K6RJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

61622:SLC7A8
gene id: 61622:SLC7A8
uniprot id: A0A2K6Q1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

61622:NIPSNAP1
gene id: 61622:NIPSNAP1
uniprot id: A0A2K6RPG3
names: Similarity
messages: Belongs to the NipSnap family.

61622:DUSP6
gene id: 61622:DUSP6
uniprot id: A0A2K6QRN5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61622:GABRP
gene id: 61622:GABRP
uniprot id: A0A2K6NVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:SIX1
gene id: 61622:SIX1
uniprot id: A0A2K6PZA9
names: Subcellular Location Annotation
messages: Nucleus

61622:APOD
gene id: 61622:APOD
uniprot id: A0A2K6RTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

61622:CCDC103
gene id: 61622:CCDC103
uniprot id: A0A2K6PB60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

61622:HABP2
gene id: 61622:HABP2
uniprot id: A0A2K6NSM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CAPN6
gene id: 61622:CAPN6
uniprot id: A0A2K6P4K9
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CCNI
gene id: 61622:CCNI
uniprot id: A0A2K6QNG1
names: Similarity
messages: Belongs to the cyclin family.

61622:LOC104680738
gene id: 61622:LOC104680738
uniprot id: A0A2K6QH48
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:NUDT1
gene id: 61622:NUDT1
uniprot id: A0A2K6NTM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

61622:LDB2
gene id: 61622:LDB2
uniprot id: A0A2K6PBK1
uniprot id: A0A2K6PBS8
names: Similarity
messages: Belongs to the LDB family.

61622:LOC104664204
gene id: 61622:LOC104664204
uniprot id: A0A2K6Q243
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:MRPL10
gene id: 61622:MRPL10
uniprot id: A0A2K6PTT8
uniprot id: A0A2K6PTV0
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

61622:WNT3
gene id: 61622:WNT3
uniprot id: A0A2K6QK28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:ACVRL1
gene id: 61622:ACVRL1
uniprot id: A0A2K6PKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:SLC25A32
gene id: 61622:SLC25A32
uniprot id: A0A2K6RBH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:S100A16
gene id: 61622:S100A16
uniprot id: A0A2K6Q947
names: Similarity
messages: Belongs to the S-100 family.

61622:RIMKLA
gene id: 61622:RIMKLA
uniprot id: A0A2K6P0A7
names: Similarity
messages: Belongs to the RimK family.

61622:EFNA5
gene id: 61622:EFNA5
uniprot id: A0A2K6PUK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ITGB4
gene id: 61622:ITGB4
uniprot id: A0A2K6N7I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

61622:VSX2
gene id: 61622:VSX2
uniprot id: A0A2K6Q2T4
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104668803
gene id: 61622:LOC104668803
uniprot id: A0A2K6RR99
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

61622:LOC104657073
gene id: 61622:LOC104657073
uniprot id: A0A2K6P3C7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:HOXA2
gene id: 61622:HOXA2
uniprot id: A0A2K6RG50
names: Subcellular Location Annotation
messages: Nucleus

61622:USO1
gene id: 61622:USO1
uniprot id: A0A2K6PC75
uniprot id: A0A2K6PCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

61622:GHRH
gene id: 61622:GHRH
uniprot id: A0A2K6R933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

61622:B4GALT6
gene id: 61622:B4GALT6
uniprot id: A0A2K6NZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:RBP5
gene id: 61622:RBP5
uniprot id: A0A2K6PT16
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:LOC104661648
gene id: 61622:LOC104661648
uniprot id: A0A2K6R0D6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:SF3B4
gene id: 61622:SF3B4
uniprot id: A0A2K6P026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

61622:PROZ
gene id: 61622:PROZ
uniprot id: A0A2K6QUT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SPA17
gene id: 61622:SPA17
uniprot id: A0A2K6PEV3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

61622:MAN1A2
gene id: 61622:MAN1A2
uniprot id: A0A2K6N7Z3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:CLIC2
gene id: 61622:CLIC2
uniprot id: A0A2K6RRZ0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:DHX8
gene id: 61622:DHX8
uniprot id: A0A2K6Q6S5
names: Subcellular Location Annotation
messages: Nucleus

61622:MPHOSPH10
gene id: 61622:MPHOSPH10
uniprot id: A0A2K6PUM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

61622:TTYH2
gene id: 61622:TTYH2
uniprot id: A0A2K6P1Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

61622:S100A10
gene id: 61622:S100A10
uniprot id: A0A2K6R4F1
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

61622:XRCC3
gene id: 61622:XRCC3
uniprot id: A0A2K6Q0K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

61622:LIN9
gene id: 61622:LIN9
uniprot id: A0A2K6QWZ3
uniprot id: A0A2K6QX15
names: Similarity
messages: Belongs to the lin-9 family.

61622:PRPF38A
gene id: 61622:PRPF38A
uniprot id: A0A2K6PLF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

61622:WLS
gene id: 61622:WLS
uniprot id: A0A2K6RSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

61622:FITM1
gene id: 61622:FITM1
uniprot id: A0A2K6RPP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

61622:CSE1L
gene id: 61622:CSE1L
uniprot id: A0A2K6NLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

61622:CASTOR1
gene id: 61622:CASTOR1
uniprot id: A0A2K6RJT5
uniprot id: A0A2K6RJU5
names: Similarity
messages: Belongs to the GATS family.

61622:SLC39A5
gene id: 61622:SLC39A5
uniprot id: A0A2K6PL86
names: Subcellular Location Annotation
messages: Membrane

61622:CD82
gene id: 61622:CD82
uniprot id: A0A2K6RMB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:FTSJ1
gene id: 61622:FTSJ1
uniprot id: A0A2K6P2G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

61622:LOC104657346
gene id: 61622:LOC104657346
uniprot id: A0A2K6QU15
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

61622:AP5M1
gene id: 61622:AP5M1
uniprot id: A0A2K6QA18
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

61622:BASP1
gene id: 61622:BASP1
uniprot id: A0A2K6NC06
names: Similarity
messages: Belongs to the BASP1 family.

61622:TMTC4
gene id: 61622:TMTC4
uniprot id: A0A2K6QNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

61622:TMEM115
gene id: 61622:TMEM115
uniprot id: A0A2K6P9H0
names: Subcellular Location Annotation
messages: Membrane

61622:VGLL2
gene id: 61622:VGLL2
uniprot id: A0A2K6R230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

61622:TMEM41B
gene id: 61622:TMEM41B
uniprot id: A0A2K6NNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

61622:GTF2H1
gene id: 61622:GTF2H1
uniprot id: A0A2K6RMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

61622:REM2
gene id: 61622:REM2
uniprot id: A0A2K6N7N2
names: Subcellular Location Annotation
messages: Cell membrane

61622:GPKOW
gene id: 61622:GPKOW
uniprot id: A0A2K6QFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

61622:EHD3
gene id: 61622:EHD3
uniprot id: A0A2K6RXQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

61622:RDH13
gene id: 61622:RDH13
uniprot id: A0A2K6R3C0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:IFT43
gene id: 61622:IFT43
uniprot id: A0A2K6Q8S1
names: Similarity
messages: Belongs to the IFT43 family.

61622:CCR4
gene id: 61622:CCR4
uniprot id: A0A2K6NQC3
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:LIN7A
gene id: 61622:LIN7A
uniprot id: A0A2K6Q0F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

61622:RPS23
gene id: 61622:RPS23
uniprot id: A0A2K6PRF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

61622:DNM2
gene id: 61622:DNM2
uniprot id: A0A2K6R323
uniprot id: A0A2K6R338
uniprot id: A0A2K6R363
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

61622:GABRE
gene id: 61622:GABRE
uniprot id: A0A2K6R445
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:PCBD1
gene id: 61622:PCBD1
uniprot id: A0A2K6QTM2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

61622:BTBD10
gene id: 61622:BTBD10
uniprot id: A0A2K6NDD7
names: Subcellular Location Annotation
messages: Cytoplasm

61622:CLRN3
gene id: 61622:CLRN3
uniprot id: A0A2K6NA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61622:PLXNA2
gene id: 61622:PLXNA2
uniprot id: A0A2K6Q9R7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ZEB2
gene id: 61622:ZEB2
uniprot id: A0A2K6QBP9
uniprot id: A0A2K6QBQ1
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

61622:TUBB1
gene id: 61622:TUBB1
uniprot id: A0A2K6P2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:ELP5
gene id: 61622:ELP5
uniprot id: A0A2K6P4H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

61622:RAD51D
gene id: 61622:RAD51D
uniprot id: A0A2K6RMQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

61622:MCM2
gene id: 61622:MCM2
uniprot id: A0A2K6RA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61622:SEC61B
gene id: 61622:SEC61B
uniprot id: A0A2K6R122
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

61622:TP53INP2
gene id: 61622:TP53INP2
uniprot id: A0A2K6QY60
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

61622:SLC16A1
gene id: 61622:SLC16A1
uniprot id: A0A2K6RT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

61622:GOLPH3
gene id: 61622:GOLPH3
uniprot id: A0A2K6QAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

61622:STK40
gene id: 61622:STK40
uniprot id: A0A2K6NQF0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

61622:NOP14
gene id: 61622:NOP14
uniprot id: A0A2K6RXF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

61622:ISM1
gene id: 61622:ISM1
uniprot id: A0A2K6PJG2
names: Similarity
messages: Belongs to the isthmin family.

61622:TGFB3
gene id: 61622:TGFB3
uniprot id: A0A2K6NAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

61622:POSTN
gene id: 61622:POSTN
uniprot id: A0A2K6QGI3
uniprot id: A0A2K6QGI9
uniprot id: A0A2K6QGJ2
uniprot id: A0A2K6QGJ3
uniprot id: A0A2K6QGL2
names: Subcellular Location Annotation
messages: extracellular matrix

61622:HNRNPA2B1
gene id: 61622:HNRNPA2B1
uniprot id: A0A2K6NKX6
uniprot id: A0A2K6NKY2
names: Subcellular Location Annotation
messages: Cytoplasmic granule

61622:SULT4A1
gene id: 61622:SULT4A1
uniprot id: A0A2K6RQH6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:NINJ1
gene id: 61622:NINJ1
uniprot id: A0A2K6QJE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

61622:LOC104667410
gene id: 61622:LOC104667410
uniprot id: A0A2K6PVS2
names: Similarity
messages: Belongs to the MIF family.

61622:RBM5
gene id: 61622:RBM5
uniprot id: A0A2K6R421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

61622:PAPSS2
gene id: 61622:PAPSS2
uniprot id: A0A2K6PVD7
uniprot id: A0A2K6PVD9
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

61622:TMEM70
gene id: 61622:TMEM70
uniprot id: A0A2K6Q805
names: Similarity
messages: Belongs to the TMEM70 family.

61622:GLI1
gene id: 61622:GLI1
uniprot id: A0A2K6PWU3
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

61622:DNM1L
gene id: 61622:DNM1L
uniprot id: A0A2K6R8V7
uniprot id: A0A2K6R8X6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

61622:INTS12
gene id: 61622:INTS12
uniprot id: A0A2K6Q2M2
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

61622:TTC25
gene id: 61622:TTC25
uniprot id: A0A2K6RIY0
names: Subcellular Location Annotation
messages: cilium axoneme

61622:TSPAN12
gene id: 61622:TSPAN12
uniprot id: A0A2K6PAV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:UROS
gene id: 61622:UROS
uniprot id: A0A2K6RL81
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

61622:XPR1
gene id: 61622:XPR1
uniprot id: A0A2K6QE73
uniprot id: A0A2K6QE77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

61622:LOC104660852
gene id: 61622:LOC104660852
uniprot id: A0A2K6NPU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61622:LIG1
gene id: 61622:LIG1
uniprot id: A0A2K6QQN7
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

61622:RPE65
gene id: 61622:RPE65
uniprot id: A0A2K6QC88
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

61622:DEFB135
gene id: 61622:DEFB135
uniprot id: A0A2K6NWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:MED29
gene id: 61622:MED29
uniprot id: A0A2K6Q440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

61622:MOXD1
gene id: 61622:MOXD1
uniprot id: A0A2K6RJ15
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

61622:TLX3
gene id: 61622:TLX3
uniprot id: A0A2K6PY45
names: Subcellular Location Annotation
messages: Nucleus

61622:KRT73
gene id: 61622:KRT73
uniprot id: A0A2K6P5T7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:VPS26B
gene id: 61622:VPS26B
uniprot id: A0A2K6QXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

61622:LAMC2
gene id: 61622:LAMC2
uniprot id: A0A2K6RWZ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

61622:GSPT1
gene id: 61622:GSPT1
uniprot id: A0A2K6PCP8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

61622:ARG2
gene id: 61622:ARG2
uniprot id: A0A2K6PXT0
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

61622:LOC104680789
gene id: 61622:LOC104680789
uniprot id: A0A2K6NEH1
names: Similarity
messages: Belongs to the NDK family.

61622:LOC104673718
gene id: 61622:LOC104673718
uniprot id: A0A2K6NHD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:RNASE4
gene id: 61622:RNASE4
uniprot id: A0A2K6NR06
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:GABRB2
gene id: 61622:GABRB2
uniprot id: A0A2K6Q4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:KCTD4
gene id: 61622:KCTD4
uniprot id: A0A2K6NK26
names: Subcellular Location Annotation
messages: Cell membrane

61622:OPA3
gene id: 61622:OPA3
uniprot id: A0A2K6PVU3
uniprot id: A0A2K6PVU6
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

61622:SCPEP1
gene id: 61622:SCPEP1
uniprot id: A0A2K6NMB7
names: Similarity
messages: Belongs to the peptidase S10 family.

61622:CFB
gene id: 61622:CFB
uniprot id: A0A2K6PAT0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CFAP45
gene id: 61622:CFAP45
uniprot id: A0A2K6PGJ8
names: Similarity
messages: Belongs to the CFAP45 family.

61622:HNF4G
gene id: 61622:HNF4G
uniprot id: A0A2K6NTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:PITX3
gene id: 61622:PITX3
uniprot id: A0A2K6NKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

61622:BLCAP
gene id: 61622:BLCAP
uniprot id: A0A2K6NJV2
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

61622:ITPRIPL1
gene id: 61622:ITPRIPL1
uniprot id: A0A2K6PNR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

61622:CRKL
gene id: 61622:CRKL
uniprot id: A0A2K6RHN4
names: Similarity
messages: Belongs to the CRK family.

61622:LOC104664126
gene id: 61622:LOC104664126
uniprot id: A0A2K6QT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:USP45
gene id: 61622:USP45
uniprot id: A0A2K6Q3V2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:TFRC
gene id: 61622:TFRC
uniprot id: A0A2K6NVI2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

61622:RPRD1A
gene id: 61622:RPRD1A
uniprot id: A0A2K6QX95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

61622:RORB
gene id: 61622:RORB
uniprot id: A0A2K6QK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:JUP
gene id: 61622:JUP
uniprot id: A0A2K6Q4F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

61622:HOXC5
gene id: 61622:HOXC5
uniprot id: A0A2K6P3P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:ANKRD13D
gene id: 61622:ANKRD13D
uniprot id: A0A2K6R1W7
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

61622:LOC104671477
gene id: 61622:LOC104671477
uniprot id: A0A2K6Q4P3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61622:HHIP
gene id: 61622:HHIP
uniprot id: A0A2K6PQ69
uniprot id: A0A2K6PQ81
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SMC6
gene id: 61622:SMC6
uniprot id: A0A2K6NLR4
names: Subcellular Location Annotation
messages: Chromosome

61622:GTPBP8
gene id: 61622:GTPBP8
uniprot id: A0A2K6NIC8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

61622:MIGA1
gene id: 61622:MIGA1
uniprot id: A0A2K6Q5Y3
names: Similarity
messages: Belongs to the mitoguardin family.

61622:SPTSSA
gene id: 61622:SPTSSA
uniprot id: A0A2K6PFN2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:SGMS2
gene id: 61622:SGMS2
uniprot id: A0A2K6QLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

61622:SCGB1D4
gene id: 61622:SCGB1D4
uniprot id: A0A2K6QVB0
names: Subcellular Location Annotation
messages: Secreted

61622:STAT2
gene id: 61622:STAT2
uniprot id: A0A2K6PBD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:VTI1B
gene id: 61622:VTI1B
uniprot id: A0A2K6QE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

61622:LMNA
gene id: 61622:LMNA
uniprot id: A0A2K6QHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

61622:SEC23B
gene id: 61622:SEC23B
uniprot id: A0A2K6RNG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:DCP1B
gene id: 61622:DCP1B
uniprot id: A0A2K6R1K4
names: Similarity
messages: Belongs to the DCP1 family.

61622:NUDT7
gene id: 61622:NUDT7
uniprot id: A0A2K6N9H9
uniprot id: A0A2K6N9J1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

61622:STAM2
gene id: 61622:STAM2
uniprot id: A0A2K6P9Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

61622:ICAM3
gene id: 61622:ICAM3
uniprot id: A0A2K6R9L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:LOC104667440
gene id: 61622:LOC104667440
uniprot id: A0A2K6NAF0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MX2
gene id: 61622:MX2
uniprot id: A0A2K6PDB5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

61622:SUMF1
gene id: 61622:SUMF1
uniprot id: A0A2K6R269
uniprot id: A0A2K6R298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

61622:SERPINA5
gene id: 61622:SERPINA5
uniprot id: A0A2K6PIF0
names: Similarity
messages: Belongs to the serpin family.

61622:LYZL4
gene id: 61622:LYZL4
uniprot id: A0A2K6NLH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

61622:DEGS1
gene id: 61622:DEGS1
uniprot id: A0A2K6NIV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:AGO3
gene id: 61622:AGO3
uniprot id: A0A2K6R9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

61622:LSS
gene id: 61622:LSS
uniprot id: A0A2K6QYG0
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

61622:PYM1
gene id: 61622:PYM1
uniprot id: A0A2K6RID3
uniprot id: A0A2K6RIG2
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

61622:TMEM225
gene id: 61622:TMEM225
uniprot id: A0A2K6Q195
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104655506
gene id: 61622:LOC104655506
uniprot id: A0A2K6NFK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CDX2
gene id: 61622:CDX2
uniprot id: A0A2K6Q967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

61622:CDK19
gene id: 61622:CDK19
uniprot id: A0A2K6R0T2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MIF
gene id: 61622:MIF
uniprot id: A0A2K6NBK0
names: Similarity
messages: Belongs to the MIF family.

61622:CDH10
gene id: 61622:CDH10
uniprot id: A0A2K6P747
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:CHRM2
gene id: 61622:CHRM2
uniprot id: A0A2K6QHQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

61622:TMEM17
gene id: 61622:TMEM17
uniprot id: A0A2K6QN45
names: Subcellular Location Annotation
messages: Membrane

61622:RBKS
gene id: 61622:RBKS
uniprot id: A0A2K6QJ34
uniprot id: A0A2K6QJ38
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

61622:COLGALT2
gene id: 61622:COLGALT2
uniprot id: A0A2K6QCG4
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

61622:POMT1
gene id: 61622:POMT1
uniprot id: A0A2K6Q127
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

61622:ACTRT1
gene id: 61622:ACTRT1
uniprot id: A0A2K6NKR7
names: Similarity
messages: Belongs to the actin family.

61622:PAQR7
gene id: 61622:PAQR7
uniprot id: A0A2K6NIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:AP4S1
gene id: 61622:AP4S1
uniprot id: A0A2K6NKC3
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

61622:LOC104667780
gene id: 61622:LOC104667780
uniprot id: A0A2K6RE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:NEK6
gene id: 61622:NEK6
uniprot id: A0A2K6R1N4
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SNX3
gene id: 61622:SNX3
uniprot id: A0A2K6QHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

61622:EXOSC8
gene id: 61622:EXOSC8
uniprot id: A0A2K6NMC5
names: Subcellular Location Annotation
messages: Cytoplasm

61622:STT3B
gene id: 61622:STT3B
uniprot id: A0A2K6NLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

61622:LOC104675469
gene id: 61622:LOC104675469
uniprot id: A0A2K6PES8
names: Similarity
messages: Belongs to the TACO1 family.

61622:LOC104681671
gene id: 61622:LOC104681671
uniprot id: A0A2K6PV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

61622:PAIP2
gene id: 61622:PAIP2
uniprot id: A0A2K6R3F3
names: Similarity
messages: Belongs to the PAIP2 family.

61622:PRDM10
gene id: 61622:PRDM10
uniprot id: A0A2K6PWE9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:SFXN5
gene id: 61622:SFXN5
uniprot id: A0A2K6PLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

61622:SF3A1
gene id: 61622:SF3A1
uniprot id: A0A2K6RRY5
names: Subcellular Location Annotation
messages: Nucleus

61622:CORO7
gene id: 61622:CORO7
uniprot id: A0A2K6RH47
uniprot id: A0A2K6RH62
names: Similarity
messages: Belongs to the WD repeat coronin family.

61622:NFE2L1
gene id: 61622:NFE2L1
uniprot id: A0A2K6RQX5
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

61622:LOC104672174
gene id: 61622:LOC104672174
uniprot id: C9DEC8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:TSPO2
gene id: 61622:TSPO2
uniprot id: A0A2K6Q4V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

61622:PPP1R15B
gene id: 61622:PPP1R15B
uniprot id: A0A2K6QZ95
names: Similarity
messages: Belongs to the PPP1R15 family.

61622:WDR83OS
gene id: 61622:WDR83OS
uniprot id: A0A2K6Q285
names: Similarity
messages: Belongs to the Asterix family.

61622:SNX2
gene id: 61622:SNX2
uniprot id: A0A2K6RFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

61622:SDR42E1
gene id: 61622:SDR42E1
uniprot id: A0A2K6PM61
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61622:RPL21
gene id: 61622:RPL21
uniprot id: A0A2K6Q5L4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

61622:GBA2
gene id: 61622:GBA2
uniprot id: A0A2K6PRS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

61622:CTSV
gene id: 61622:CTSV
uniprot id: A0A2K6Q357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:TRIM72
gene id: 61622:TRIM72
uniprot id: A0A2K6PF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

61622:SLC25A23
gene id: 61622:SLC25A23
uniprot id: A0A2K6NDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:PTX3
gene id: 61622:PTX3
uniprot id: A0A2K6Q438
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:APOM
gene id: 61622:APOM
uniprot id: A0A2K6PNZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

61622:LOC104668690
gene id: 61622:LOC104668690
uniprot id: A0A2K6R0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:FAM13C
gene id: 61622:FAM13C
uniprot id: A0A2K6RUL7
names: Similarity
messages: Belongs to the FAM13 family.

61622:ASB6
gene id: 61622:ASB6
uniprot id: A0A2K6PCK3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:CDC34
gene id: 61622:CDC34
uniprot id: A0A2K6PVJ6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:RAB3GAP2
gene id: 61622:RAB3GAP2
uniprot id: A0A2K6PHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

61622:UCHL5
gene id: 61622:UCHL5
uniprot id: A0A2K6NWM1
uniprot id: A0A2K6NWM7
names: Similarity
messages: Belongs to the peptidase C12 family.

61622:LOC104663505
gene id: 61622:LOC104663505
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TOR3A
gene id: 61622:TOR3A
uniprot id: A0A2K6PAR2
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

61622:ACVR2A
gene id: 61622:ACVR2A
uniprot id: A0A2K6NIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:CNMD
gene id: 61622:CNMD
uniprot id: A0A2K6QRT0
names: Similarity
messages: Belongs to the chondromodulin-1 family.

61622:BABAM1
gene id: 61622:BABAM1
uniprot id: A0A2K6PVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

61622:POLR1A
gene id: 61622:POLR1A
uniprot id: A0A2K6PDI7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:OSBPL6
gene id: 61622:OSBPL6
uniprot id: A0A2K6Q7X9
uniprot id: A0A2K6Q7Z8
names: Similarity
messages: Belongs to the OSBP family.

61622:CLCA2
gene id: 61622:CLCA2
uniprot id: A0A2K6PL34
names: Similarity
messages: Belongs to the CLCR family.

61622:WNT8B
gene id: 61622:WNT8B
uniprot id: A0A2K6PYK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:LOC104681937
gene id: 61622:LOC104681937
uniprot id: A0A2K6PEE5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:TRPM2
gene id: 61622:TRPM2
uniprot id: A0A2K6PNY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
messages: Cell membrane
messages: Membrane

61622:CSNK1G1
gene id: 61622:CSNK1G1
uniprot id: A0A2K6QLU7
uniprot id: A0A2K6QLW1
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

61622:AP4B1
gene id: 61622:AP4B1
uniprot id: A0A2K6P5Q6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:LOC104672629
gene id: 61622:LOC104672629
uniprot id: A0A2K6QR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61622:LOC104678634
gene id: 61622:LOC104678634
uniprot id: A0A2K6QN53
uniprot id: A0A2K6QN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

61622:TBK1
gene id: 61622:TBK1
uniprot id: A0A2K6RG10
names: Subcellular Location Annotation
messages: Cytoplasm

61622:HACD1
gene id: 61622:HACD1
uniprot id: A0A2K6NR84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:WNT2
gene id: 61622:WNT2
uniprot id: A0A2K6NI98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:KCND1
gene id: 61622:KCND1
uniprot id: A0A2K6RLU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

61622:OTC
gene id: 61622:OTC
uniprot id: A0A2K6R482
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

61622:MED10
gene id: 61622:MED10
uniprot id: A0A2K6PH24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:NDUFC1
gene id: 61622:NDUFC1
uniprot id: A0A2K6NPD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:CALB2
gene id: 61622:CALB2
uniprot id: A0A2K6RQI5
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

61622:AXL
gene id: 61622:AXL
uniprot id: A0A2K6QFC7
uniprot id: A0A2K6QFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

61622:TCAF1
gene id: 61622:TCAF1
uniprot id: A0A2K6RFE8
uniprot id: A0A2K6RFF6
names: Similarity
messages: Belongs to the TCAF family.

61622:KXD1
gene id: 61622:KXD1
uniprot id: A0A2K6PTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

61622:CCT6A
gene id: 61622:CCT6A
uniprot id: A0A2K6QFM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

61622:FABP7
gene id: 61622:FABP7
uniprot id: A0A2K6R7A9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:IL36B
gene id: 61622:IL36B
uniprot id: A0A2K6P5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:ARHGEF2
gene id: 61622:ARHGEF2
uniprot id: A0A2K6PLG3
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

61622:MAP2K6
gene id: 61622:MAP2K6
uniprot id: A0A2K6P648
uniprot id: A0A2K6P656
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:ITPKC
gene id: 61622:ITPKC
uniprot id: A0A2K6RV31
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:LOC104663414
gene id: 61622:LOC104663414
uniprot id: A0A2K6NDX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:DLK2
gene id: 61622:DLK2
uniprot id: A0A2K6RVT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TIMELESS
gene id: 61622:TIMELESS
uniprot id: A0A2K6NZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

61622:LOC104680718
gene id: 61622:LOC104680718
uniprot id: A0A2K6PKK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61622:NR4A3
gene id: 61622:NR4A3
uniprot id: A0A2K6RK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:ALG3
gene id: 61622:ALG3
uniprot id: A0A2K6RWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PDE1A
gene id: 61622:PDE1A
uniprot id: A0A2K6PZM6
uniprot id: A0A2K6PZM8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:NOX5
gene id: 61622:NOX5
uniprot id: A0A2K6QXT0
names: Subcellular Location Annotation
messages: Membrane

61622:CEL
gene id: 61622:CEL
uniprot id: A0A2K6RK83
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61622:CD2
gene id: 61622:CD2
uniprot id: A0A2K6NN56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:BMP2
gene id: 61622:BMP2
uniprot id: A0A2K6P4A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

61622:SFN
gene id: 61622:SFN
uniprot id: A0A2K6N9G8
names: Similarity
messages: Belongs to the 14-3-3 family.

61622:VPS72
gene id: 61622:VPS72
uniprot id: A0A2K6NS23
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

61622:OCA2
gene id: 61622:OCA2
uniprot id: A0A2K6PF79
names: Subcellular Location Annotation
messages: Membrane

61622:YES1
gene id: 61622:YES1
uniprot id: A0A2K6PNW5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:TNFSF13B
gene id: 61622:TNFSF13B
uniprot id: A0A2K6QU57
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:DCBLD1
gene id: 61622:DCBLD1
uniprot id: A0A2K6R0Z7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CLCA1
gene id: 61622:CLCA1
uniprot id: A0A2K6NXP8
names: Similarity
messages: Belongs to the CLCR family.

61622:SEMA6D
gene id: 61622:SEMA6D
uniprot id: A0A2K6NYN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PSMA1
gene id: 61622:PSMA1
uniprot id: A0A2K6QGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:RPS13
gene id: 61622:RPS13
uniprot id: A0A2K6QGL4
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

61622:CASQ1
gene id: 61622:CASQ1
uniprot id: A0A2K6RFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

61622:LOC104654355
gene id: 61622:LOC104654355
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:ELP4
gene id: 61622:ELP4
uniprot id: A0A2K6NN70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

61622:ADIPOR2
gene id: 61622:ADIPOR2
uniprot id: A0A2K6NKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:DGUOK
gene id: 61622:DGUOK
uniprot id: A0A2K6NYL0
uniprot id: A0A2K6NYL3
names: Similarity
messages: Belongs to the DCK/DGK family.

61622:RXFP1
gene id: 61622:RXFP1
uniprot id: A0A2K6Q4A8
uniprot id: A0A2K6Q4B1
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ADCYAP1
gene id: 61622:ADCYAP1
uniprot id: A0A2K6RHE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

61622:SDR9C7
gene id: 61622:SDR9C7
uniprot id: A0A2K6PPM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:MCEE
gene id: 61622:MCEE
uniprot id: A0A2K6NKE3
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

61622:ACSS2
gene id: 61622:ACSS2
uniprot id: A0A2K6P2B4
uniprot id: A0A2K6P2C4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:PAPOLG
gene id: 61622:PAPOLG
uniprot id: A0A2K6Q682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

61622:PIAS1
gene id: 61622:PIAS1
uniprot id: A0A2K6NYY5
names: Similarity
messages: Belongs to the PIAS family.

61622:KCTD18
gene id: 61622:KCTD18
uniprot id: A0A2K6RJD1
names: Subcellular Location Annotation
messages: Cell membrane

61622:WASHC3
gene id: 61622:WASHC3
uniprot id: A0A2K6NYC3
names: Similarity
messages: Belongs to the CCDC53 family.

61622:RBM15
gene id: 61622:RBM15
uniprot id: A0A2K6RW02
uniprot id: A0A2K6RW04
names: Similarity
messages: Belongs to the RRM Spen family.

61622:NAP1L1
gene id: 61622:NAP1L1
uniprot id: A0A2K6NRU5
uniprot id: A0A2K6NRU7
uniprot id: A0A2K6NRV6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:P2RY2
gene id: 61622:P2RY2
uniprot id: A0A2K6NPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:OTOP2
gene id: 61622:OTOP2
uniprot id: A0A2K6NR87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61622:HNRNPDL
gene id: 61622:HNRNPDL
uniprot id: A0A2K6PVB3
uniprot id: A0A2K6PVB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104663428
gene id: 61622:LOC104663428
uniprot id: A0A2K6QKI8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:NME6
gene id: 61622:NME6
uniprot id: A0A2K6NZS1
names: Similarity
messages: Belongs to the NDK family.

61622:BCKDHA
gene id: 61622:BCKDHA
uniprot id: A0A2K6QXC8
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.

61622:HGD
gene id: 61622:HGD
uniprot id: A0A2K6P4V3
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

61622:NEDD8
gene id: 61622:NEDD8
uniprot id: A0A2K6Q6C6
names: Similarity
messages: Belongs to the ubiquitin family.

61622:NEUROD2
gene id: 61622:NEUROD2
uniprot id: A0A2K6NBZ4
names: Subcellular Location Annotation
messages: Nucleus

61622:PPP1R12C
gene id: 61622:PPP1R12C
uniprot id: A0A2K6R8B6
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

61622:LSM12
gene id: 61622:LSM12
uniprot id: A0A2K6RW27
names: Similarity
messages: Belongs to the LSM12 family.

61622:MED23
gene id: 61622:MED23
uniprot id: A0A2K6PYA8
uniprot id: A0A2K6PYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

61622:SULT1B1
gene id: 61622:SULT1B1
uniprot id: A0A2K6PFP4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:EOGT
gene id: 61622:EOGT
uniprot id: A0A2K6P378
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

61622:SGCG
gene id: 61622:SGCG
uniprot id: A0A2K6NXY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

61622:KCNS1
gene id: 61622:KCNS1
uniprot id: A0A2K6RS78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:ARL11
gene id: 61622:ARL11
uniprot id: A0A2K6N7H7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:SERPINB6
gene id: 61622:SERPINB6
uniprot id: A0A2K6RBT5
names: Similarity
messages: Belongs to the serpin family.

61622:RBCK1
gene id: 61622:RBCK1
uniprot id: A0A2K6QHZ2
names: Similarity
messages: Belongs to the RBR family.

61622:LBR
gene id: 61622:LBR
uniprot id: A0A2K6QZG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

61622:C12H1orf52
gene id: 61622:C12H1orf52
uniprot id: A0A2K6NTS6
uniprot id: A0A2K6NTU9
names: Similarity
messages: Belongs to the UPF0690 family.

61622:SERPINA7
gene id: 61622:SERPINA7
uniprot id: A0A2K6Q1V9
names: Similarity
messages: Belongs to the serpin family.

61622:SPC25
gene id: 61622:SPC25
uniprot id: A0A2K6PTS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61622:HBE1
gene id: 61622:HBE1
uniprot id: A0A2K6R3K8
names: Similarity
messages: Belongs to the globin family.

61622:NPPB
gene id: 61622:NPPB
uniprot id: A0A2K6PKP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

61622:NDUFS2
gene id: 61622:NDUFS2
uniprot id: A0A2K6PJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 49 kDa subunit family.
messages: Mitochondrion inner membrane

61622:PSENEN
gene id: 61622:PSENEN
uniprot id: A0A2K6R377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

61622:TFIP11
gene id: 61622:TFIP11
uniprot id: A0A2K6PZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

61622:SDF4
gene id: 61622:SDF4
uniprot id: A0A2K6PZZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

61622:TMEM225B
gene id: 61622:TMEM225B
uniprot id: A0A2K6NQ03
names: Subcellular Location Annotation
messages: Membrane

61622:METTL26
gene id: 61622:METTL26
uniprot id: A0A2K6PEK4
names: Similarity
messages: Belongs to the UPF0585 family.

61622:RIPK2
gene id: 61622:RIPK2
uniprot id: A0A2K6RXI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

61622:PSMC3
gene id: 61622:PSMC3
uniprot id: A0A2K6R7G9
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:HBQ1
gene id: 61622:HBQ1
uniprot id: A0A2K6NMM6
names: Similarity
messages: Belongs to the globin family.

61622:NAALADL1
gene id: 61622:NAALADL1
uniprot id: A0A2K6R5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61622:RARA
gene id: 61622:RARA
uniprot id: A0A2K6PN06
uniprot id: A0A2K6PN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:CRH
gene id: 61622:CRH
uniprot id: A0A2K6NSC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

61622:SNAPC3
gene id: 61622:SNAPC3
uniprot id: A0A2K6RMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

61622:ODR4
gene id: 61622:ODR4
uniprot id: A0A2K6PMH9
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

61622:NGLY1
gene id: 61622:NGLY1
uniprot id: A0A2K6Q217
uniprot id: A0A2K6Q228
uniprot id: A0A2K6Q231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

61622:S100A8
gene id: 61622:S100A8
uniprot id: A0A2K6QU61
names: Similarity
messages: Belongs to the S-100 family.

61622:ZNF215
gene id: 61622:ZNF215
uniprot id: A0A2K6P8L7
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC13A5
gene id: 61622:SLC13A5
uniprot id: A0A2K6NE11
uniprot id: A0A2K6NE19
uniprot id: A0A2K6NE32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:SLC16A13
gene id: 61622:SLC16A13
uniprot id: A0A2K6PA03
names: Subcellular Location Annotation
messages: Membrane

61622:MFRP
gene id: 61622:MFRP
uniprot id: A0A2K6QZG8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NDUFB1
gene id: 61622:NDUFB1
uniprot id: A0A2K6P5U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:GGCX
gene id: 61622:GGCX
uniprot id: A0A2K6QG18
uniprot id: A0A2K6QG40
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PROM2
gene id: 61622:PROM2
uniprot id: A0A2K6QPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

61622:MPP6
gene id: 61622:MPP6
uniprot id: A0A2K6QDG0
names: Similarity
messages: Belongs to the MAGUK family.

61622:TSPO
gene id: 61622:TSPO
uniprot id: A0A2K6QYT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

61622:PUS3
gene id: 61622:PUS3
uniprot id: A0A2K6Q1X6
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

61622:ASB8
gene id: 61622:ASB8
uniprot id: A0A2K6PST1
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

61622:TRIM15
gene id: 61622:TRIM15
uniprot id: A0A2K6N8V7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:NDUFC2
gene id: 61622:NDUFC2
uniprot id: A0A2K6NUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

61622:FAM167B
gene id: 61622:FAM167B
uniprot id: A0A2K6PU96
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

61622:MRTO4
gene id: 61622:MRTO4
uniprot id: A0A2K6RD65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

61622:CTNND2
gene id: 61622:CTNND2
uniprot id: A0A2K6NNH4
names: Similarity
messages: Belongs to the beta-catenin family.

61622:PEX13
gene id: 61622:PEX13
uniprot id: A0A2K6PCU0
names: Similarity
messages: Belongs to the peroxin-13 family.

61622:ADPRHL2
gene id: 61622:ADPRHL2
uniprot id: A0A2K6P5D1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

61622:CDK6
gene id: 61622:CDK6
uniprot id: A0A2K6P4F4
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:CD6
gene id: 61622:CD6
uniprot id: A0A2K6RU16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MYOZ2
gene id: 61622:MYOZ2
uniprot id: A0A2K6P8R7
names: Similarity
messages: Belongs to the myozenin family.

61622:BLK
gene id: 61622:BLK
uniprot id: A0A2K6QZ25
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:ERBB3
gene id: 61622:ERBB3
uniprot id: A0A2K6P363
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

61622:MRPL54
gene id: 61622:MRPL54
uniprot id: A0A2K6NJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

61622:CMC4
gene id: 61622:CMC4
uniprot id: A0A2K6PE97
names: Similarity
messages: Belongs to the CMC4 family.

61622:ITGA10
gene id: 61622:ITGA10
uniprot id: A0A2K6QL11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:TMEM237
gene id: 61622:TMEM237
uniprot id: A0A2K6RIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

61622:NT5C3A
gene id: 61622:NT5C3A
uniprot id: A0A2K6P9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

61622:CHST2
gene id: 61622:CHST2
uniprot id: A0A2K6NJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61622:KHDC3L
gene id: 61622:KHDC3L
uniprot id: A0A2K6PBK0
names: Similarity
messages: Belongs to the KHDC1 family.

61622:MAP1LC3A
gene id: 61622:MAP1LC3A
uniprot id: A0A2K6PII6
names: Similarity
messages: Belongs to the ATG8 family.

61622:GTF2H4
gene id: 61622:GTF2H4
uniprot id: A0A2K6RUV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

61622:MPHOSPH8
gene id: 61622:MPHOSPH8
uniprot id: A0A2K6RME7
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104657315
gene id: 61622:LOC104657315
uniprot id: A0A2K6NB94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61622:LOC104674934
gene id: 61622:LOC104674934
uniprot id: A0A2K6NJS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:HOXB5
gene id: 61622:HOXB5
uniprot id: A0A2K6P899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:CD14
gene id: 61622:CD14
uniprot id: A0A2K6QJE2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

61622:NPY
gene id: 61622:NPY
uniprot id: A0A2K6PZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

61622:NCDN
gene id: 61622:NCDN
uniprot id: A0A2K6RCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

61622:ATG5
gene id: 61622:ATG5
uniprot id: A0A2K6RC07
uniprot id: A0A2K6RC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

61622:BTK
gene id: 61622:BTK
uniprot id: A0A2K6PTH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

61622:KPNA3
gene id: 61622:KPNA3
uniprot id: A0A2K6R1J6
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:COG2
gene id: 61622:COG2
uniprot id: A0A2K6QF01
names: Similarity
messages: Belongs to the COG2 family.

61622:CCDC65
gene id: 61622:CCDC65
uniprot id: A0A2K6NZA6
names: Subcellular Location Annotation
messages: flagellum axoneme

61622:FAM131A
gene id: 61622:FAM131A
uniprot id: A0A2K6NZD4
names: Similarity
messages: Belongs to the FAM131 family.

61622:ERGIC2
gene id: 61622:ERGIC2
uniprot id: A0A2K6NIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

61622:PRKCI
gene id: 61622:PRKCI
uniprot id: A0A2K6QNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

61622:LOC104667825
gene id: 61622:LOC104667825
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:PRICKLE1
gene id: 61622:PRICKLE1
uniprot id: A0A2K6QXE8
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61622:RPS20
gene id: 61622:RPS20
uniprot id: A0A2K6PWQ6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

61622:NEFH
gene id: 61622:NEFH
uniprot id: A0A2K6R190
names: Similarity
messages: Belongs to the intermediate filament family.

61622:KCNJ5
gene id: 61622:KCNJ5
uniprot id: A0A2K6R7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

61622:STMN2
gene id: 61622:STMN2
uniprot id: A0A2K6NZY0
names: Similarity
messages: Belongs to the stathmin family.

61622:KEG34 p04
gene id: 61622:KEG34_p04
uniprot id: Q15GN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:AIF1L
gene id: 61622:AIF1L
uniprot id: A0A2K6RD24
names: Subcellular Location Annotation
messages: ruffle membrane

61622:SLC39A10
gene id: 61622:SLC39A10
uniprot id: A0A2K6QW25
names: Subcellular Location Annotation
messages: Membrane

61622:ATP6V1D
gene id: 61622:ATP6V1D
uniprot id: A0A2K6QUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

61622:ACTL7B
gene id: 61622:ACTL7B
uniprot id: A0A2K6ND29
names: Similarity
messages: Belongs to the actin family.

61622:TUBA8
gene id: 61622:TUBA8
uniprot id: A0A2K6NP71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:CD3E
gene id: 61622:CD3E
uniprot id: A0A2K6P999
names: Subcellular Location Annotation
messages: Membrane

61622:CRYBG3
gene id: 61622:CRYBG3
uniprot id: A0A2K6RTA9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:VCAM1
gene id: 61622:VCAM1
uniprot id: A0A2K6NXP7
names: Subcellular Location Annotation
messages: Cell membrane

61622:ENKUR
gene id: 61622:ENKUR
uniprot id: A0A2K6PTD6
uniprot id: A0A2K6PTE5
names: Subcellular Location Annotation
messages: cilium axoneme

61622:GSTP1
gene id: 61622:GSTP1
uniprot id: A0A2K6NSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

61622:BLOC1S2
gene id: 61622:BLOC1S2
uniprot id: A0A2K6RLX9
names: Similarity
messages: Belongs to the BLOC1S2 family.

61622:VAMP4
gene id: 61622:VAMP4
uniprot id: A0A2K6Q965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:NEK8
gene id: 61622:NEK8
uniprot id: A0A2K6P0B4
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

61622:ATP5MF
gene id: 61622:ATP5MF
uniprot id: A0A2K6Q417
uniprot id: A0A2K6Q420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

61622:FOXJ2
gene id: 61622:FOXJ2
uniprot id: A0A2K6PID9
names: Subcellular Location Annotation
messages: Nucleus

61622:FSCN3
gene id: 61622:FSCN3
uniprot id: A0A2K6RDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:TNP2
gene id: 61622:TNP2
uniprot id: A0A2K6NXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

61622:TMEM120B
gene id: 61622:TMEM120B
uniprot id: A0A2K6NES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

61622:RPL36
gene id: 61622:RPL36
uniprot id: A0A2K6NTS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61622:AKAP5
gene id: 61622:AKAP5
uniprot id: A0A2K6NKS3
names: Subcellular Location Annotation
messages: Membrane

61622:AGAP2
gene id: 61622:AGAP2
uniprot id: A0A2K6NM77
names: Similarity
messages: Belongs to the centaurin gamma-like family.

61622:TMCC2
gene id: 61622:TMCC2
uniprot id: A0A2K6RAR7
uniprot id: A0A2K6RAT5
names: Similarity
messages: Belongs to the TEX28 family.

61622:DAPK2
gene id: 61622:DAPK2
uniprot id: A0A2K6P1G1
uniprot id: A0A2K6P1G2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:DMRTC2
gene id: 61622:DMRTC2
uniprot id: A0A2K6R100
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:LOC104654549
gene id: 61622:LOC104654549
uniprot id: A0A2K6P3C7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:ACYP2
gene id: 61622:ACYP2
uniprot id: A0A2K6NGY7
names: Similarity
messages: Belongs to the acylphosphatase family.

61622:SLC16A4
gene id: 61622:SLC16A4
uniprot id: A0A2K6NXL3
names: Subcellular Location Annotation
messages: Membrane

61622:CRB2
gene id: 61622:CRB2
uniprot id: A0A2K6RKY7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HHIPL2
gene id: 61622:HHIPL2
uniprot id: A0A2K6R535
names: Similarity
messages: Belongs to the HHIP family.

61622:MSRA
gene id: 61622:MSRA
uniprot id: A0A2K6PJL9
uniprot id: A0A2K6PJM9
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

61622:ISOC1
gene id: 61622:ISOC1
uniprot id: A0A2K6RTQ5
names: Similarity
messages: Belongs to the isochorismatase family.

61622:CLCN2
gene id: 61622:CLCN2
uniprot id: A0A2K6PXD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

61622:MAML3
gene id: 61622:MAML3
uniprot id: A0A2K6QSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

61622:LOC104679886
gene id: 61622:LOC104679886
uniprot id: A0A2K6N726
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61622:DIP2B
gene id: 61622:DIP2B
uniprot id: A0A2K6QPU3
names: Similarity
messages: Belongs to the DIP2 family.

61622:ACYP1
gene id: 61622:ACYP1
uniprot id: A0A2K6QE96
uniprot id: A0A2K6QE99
names: Similarity
messages: Belongs to the acylphosphatase family.

61622:PITPNM1
gene id: 61622:PITPNM1
uniprot id: A0A2K6NBZ0
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

61622:ITGA4
gene id: 61622:ITGA4
uniprot id: A0A2K6NH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:SEC24C
gene id: 61622:SEC24C
uniprot id: A0A2K6PVH2
uniprot id: A0A2K6PVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:PARP8
gene id: 61622:PARP8
uniprot id: A0A2K6NS56
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:PIGG
gene id: 61622:PIGG
uniprot id: A0A2K6PID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PYCARD
gene id: 61622:PYCARD
uniprot id: A0A2K6RFU5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

61622:METTL11B
gene id: 61622:METTL11B
uniprot id: A0A2K6R9T8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

61622:CCNYL1
gene id: 61622:CCNYL1
uniprot id: A0A2K6QN69
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

61622:HADH
gene id: 61622:HADH
uniprot id: A0A2K6Q1I3
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

61622:RNPEP
gene id: 61622:RNPEP
uniprot id: A0A2K6RH43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:QARS1
gene id: 61622:QARS1
uniprot id: A0A2K6Q0A5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:LOC104659883
gene id: 61622:LOC104659883
uniprot id: A0A2K6QTP2
uniprot id: A0A2K6QTR7
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.