608506:COB47 RS01570
gene id: 608506:COB47_RS01570
uniprot id: D9TI34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

608506:COB47 RS07970
gene id: 608506:COB47_RS07970
uniprot id: D9TFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

608506:COB47 RS04260
gene id: 608506:COB47_RS04260
uniprot id: D9TJI3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

608506:COB47 RS02915
gene id: 608506:COB47_RS02915
uniprot id: D9TIS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS04230
gene id: 608506:COB47_RS04230
uniprot id: D9TJH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

608506:COB47 RS05610
gene id: 608506:COB47_RS05610
uniprot id: D9TK78
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

608506:COB47 RS05365
gene id: 608506:COB47_RS05365
uniprot id: D9TK29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

608506:COB47 RS08770
gene id: 608506:COB47_RS08770
uniprot id: D9TFQ6
names: Similarity
messages: Belongs to the EamA transporter family.

608506:COB47 RS00525
gene id: 608506:COB47_RS00525
uniprot id: D9THB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system.

608506:COB47 RS08395
gene id: 608506:COB47_RS08395
uniprot id: D9TFI3
names: Similarity
messages: Belongs to the glycosyl hydrolase 9 (cellulase E) family.

608506:COB47 RS10865
gene id: 608506:COB47_RS10865
uniprot id: D9TH15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

608506:COB47 RS02835
gene id: 608506:COB47_RS02835
uniprot id: D9TIR0
names: Similarity
messages: Belongs to the PGI/PMI family.

608506:COB47 RS05305
gene id: 608506:COB47_RS05305
uniprot id: D9TK17
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

608506:COB47 RS05205
gene id: 608506:COB47_RS05205
uniprot id: D9TK04
names: Similarity
messages: Belongs to the peptidase S16 family.

608506:COB47 RS11685
gene id: 608506:COB47_RS11685
uniprot id: D9THS8
names: Similarity
messages: Belongs to the ParB family.

608506:COB47 RS03925
gene id: 608506:COB47_RS03925
uniprot id: D9TJC0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS07760
gene id: 608506:COB47_RS07760
uniprot id: D9TLE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

608506:COB47 RS07615
gene id: 608506:COB47_RS07615
uniprot id: D9TLC0
names: Similarity
messages: Belongs to the asp23 family.

608506:COB47 RS11740
gene id: 608506:COB47_RS11740
uniprot id: D9THT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

608506:COB47 RS03945
gene id: 608506:COB47_RS03945
uniprot id: D9TJC4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS03555
gene id: 608506:COB47_RS03555
uniprot id: D9TJ47
names: Similarity
messages: Belongs to the sigma-70 factor family.

608506:COB47 RS08090
gene id: 608506:COB47_RS08090
uniprot id: D9TFC4
names: Similarity
messages: Belongs to the peptidase S41A family.

608506:COB47 RS06395
gene id: 608506:COB47_RS06395
uniprot id: D9TKM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

608506:COB47 RS06100
gene id: 608506:COB47_RS06100
uniprot id: D9TKG8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

608506:COB47 RS06465
gene id: 608506:COB47_RS06465
uniprot id: D9TKP2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

608506:COB47 RS00285
gene id: 608506:COB47_RS00285
uniprot id: D9TGU8
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

608506:COB47 RS03430
gene id: 608506:COB47_RS03430
uniprot id: D9TJ22
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

608506:COB47 RS02665
gene id: 608506:COB47_RS02665
uniprot id: D9TIM6
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05570
gene id: 608506:COB47_RS05570
uniprot id: D9TK70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

608506:COB47 RS09470
gene id: 608506:COB47_RS09470
uniprot id: D9TG36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608506:COB47 RS07430
gene id: 608506:COB47_RS07430
uniprot id: D9TL84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

608506:COB47 RS07150
gene id: 608506:COB47_RS07150
uniprot id: D9TL29
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

608506:COB47 RS02235
gene id: 608506:COB47_RS02235
uniprot id: D9TIE6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS03365
gene id: 608506:COB47_RS03365
uniprot id: D9TJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

608506:COB47 RS06585
gene id: 608506:COB47_RS06585
uniprot id: D9TKR6
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

608506:COB47 RS10935
gene id: 608506:COB47_RS10935
uniprot id: D9TH26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS08845
gene id: 608506:COB47_RS08845
uniprot id: D9TFS1
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

608506:COB47 RS02955
gene id: 608506:COB47_RS02955
uniprot id: D9TIT5
names: Similarity
messages: Belongs to the glutamine synthetase family.

608506:COB47 RS09220
gene id: 608506:COB47_RS09220
uniprot id: D9TFZ2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

608506:COB47 RS07340
gene id: 608506:COB47_RS07340
uniprot id: D9TL66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS09985
gene id: 608506:COB47_RS09985
uniprot id: D9TGD5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS03655
gene id: 608506:COB47_RS03655
uniprot id: D9TJ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

608506:COB47 RS10175
gene id: 608506:COB47_RS10175
uniprot id: D9TGH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608506:COB47 RS07705
gene id: 608506:COB47_RS07705
uniprot id: D9TLD8
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608506:COB47 RS03360
gene id: 608506:COB47_RS03360
uniprot id: D9TJ13
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

608506:COB47 RS07985
gene id: 608506:COB47_RS07985
uniprot id: D9TFA3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

608506:COB47 RS03070
gene id: 608506:COB47_RS03070
uniprot id: D9TIV8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

608506:COB47 RS04305
gene id: 608506:COB47_RS04305
uniprot id: D9TJJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

608506:COB47 RS04500
gene id: 608506:COB47_RS04500
uniprot id: D9TJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

608506:COB47 RS04185
gene id: 608506:COB47_RS04185
uniprot id: D9TJG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

608506:COB47 RS05315
gene id: 608506:COB47_RS05315
uniprot id: D9TK19
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

608506:COB47 RS05765
gene id: 608506:COB47_RS05765
uniprot id: D9TKA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS03060
gene id: 608506:COB47_RS03060
uniprot id: D9TIV6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS08605
gene id: 608506:COB47_RS08605
uniprot id: D9TFM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

608506:COB47 RS08785
gene id: 608506:COB47_RS08785
uniprot id: D9TFQ9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

608506:COB47 RS03265
gene id: 608506:COB47_RS03265
uniprot id: D9TIZ6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

608506:COB47 RS06960
gene id: 608506:COB47_RS06960
uniprot id: D9TKY9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

608506:COB47 RS02060
gene id: 608506:COB47_RS02060
uniprot id: D9TIC0
names: Similarity
messages: Belongs to the PemK/MazF family.

608506:COB47 RS09365
gene id: 608506:COB47_RS09365
uniprot id: D9TG16
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS09610
gene id: 608506:COB47_RS09610
uniprot id: D9TG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

608506:COB47 RS05085
gene id: 608506:COB47_RS05085
uniprot id: D9TJY2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS05880
gene id: 608506:COB47_RS05880
uniprot id: D9TKD1
names: Similarity
messages: Belongs to the leucine-binding protein family.

608506:COB47 RS03875
gene id: 608506:COB47_RS03875
uniprot id: D9TJB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608506:COB47 RS03125
gene id: 608506:COB47_RS03125
uniprot id: D9TIW8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

608506:COB47 RS02580
gene id: 608506:COB47_RS02580
uniprot id: D9TIL0
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS07590
gene id: 608506:COB47_RS07590
uniprot id: D9TLB5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

608506:COB47 RS09830
gene id: 608506:COB47_RS09830
uniprot id: D9TGB0
names: Similarity
messages: Belongs to the DprA/Smf family.

608506:COB47 RS05275
gene id: 608506:COB47_RS05275
uniprot id: D9TK11
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

608506:COB47 RS08655
gene id: 608506:COB47_RS08655
uniprot id: D9TFN5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

608506:COB47 RS05025
gene id: 608506:COB47_RS05025
uniprot id: D9TJX0
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

608506:COB47 RS07595
gene id: 608506:COB47_RS07595
uniprot id: D9TLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

608506:COB47 RS05440
gene id: 608506:COB47_RS05440
uniprot id: D9TK44
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

608506:COB47 RS09175
gene id: 608506:COB47_RS09175
uniprot id: D9TFY2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS03910
gene id: 608506:COB47_RS03910
uniprot id: D9TJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS09395
gene id: 608506:COB47_RS09395
uniprot id: D9TG21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

608506:COB47 RS07330
gene id: 608506:COB47_RS07330
uniprot id: D9TL65
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

608506:COB47 RS04275
gene id: 608506:COB47_RS04275
uniprot id: D9TJI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS09090
gene id: 608506:COB47_RS09090
uniprot id: D9TFW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

608506:COB47 RS04060
gene id: 608506:COB47_RS04060
uniprot id: D9TJE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

608506:COB47 RS01605
gene id: 608506:COB47_RS01605
uniprot id: D9TI41
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

608506:COB47 RS11660
gene id: 608506:COB47_RS11660
uniprot id: D9THS3
names: Similarity
messages: Belongs to the class-I fumarase family.

608506:COB47 RS08600
gene id: 608506:COB47_RS08600
uniprot id: D9TFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

608506:COB47 RS10805
gene id: 608506:COB47_RS10805
uniprot id: D9TH04
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

608506:COB47 RS11250
gene id: 608506:COB47_RS11250
uniprot id: D9TH79
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS09545
gene id: 608506:COB47_RS09545
uniprot id: D9TG54
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

608506:COB47 RS05810
gene id: 608506:COB47_RS05810
uniprot id: D9TKB8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

608506:COB47 RS05450
gene id: 608506:COB47_RS05450
uniprot id: D9TK46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

608506:COB47 RS05665
gene id: 608506:COB47_RS05665
uniprot id: D9TK89
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

608506:COB47 RS04570
gene id: 608506:COB47_RS04570
uniprot id: D9TJN7
names: Similarity
messages: Belongs to the bacterial flagellin family.

608506:COB47 RS08915
gene id: 608506:COB47_RS08915
uniprot id: D9TFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

608506:COB47 RS01750
gene id: 608506:COB47_RS01750
uniprot id: D9TI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS12125
gene id: 608506:COB47_RS12125
uniprot id: D9TKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

608506:COB47 RS06950
gene id: 608506:COB47_RS06950
uniprot id: D9TKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

608506:COB47 RS03325
gene id: 608506:COB47_RS03325
uniprot id: D9TJ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

608506:COB47 RS01265
gene id: 608506:COB47_RS01265
uniprot id: D9THX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

608506:COB47 RS01485
gene id: 608506:COB47_RS01485
uniprot id: D9TI19
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05340
gene id: 608506:COB47_RS05340
uniprot id: D9TK24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

608506:COB47 RS02465
gene id: 608506:COB47_RS02465
uniprot id: D9TIJ1
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

608506:COB47 RS09805
gene id: 608506:COB47_RS09805
uniprot id: D9TGA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

608506:COB47 RS07120
gene id: 608506:COB47_RS07120
uniprot id: D9TL23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

608506:COB47 RS02920
gene id: 608506:COB47_RS02920
uniprot id: D9TIS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

608506:COB47 RS06505
gene id: 608506:COB47_RS06505
uniprot id: D9TKQ0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

608506:COB47 RS07395
gene id: 608506:COB47_RS07395
uniprot id: D9TL77
names: Similarity
messages: Belongs to the ribF family.

608506:COB47 RS07755
gene id: 608506:COB47_RS07755
uniprot id: D9TLE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

608506:COB47 RS05170
gene id: 608506:COB47_RS05170
uniprot id: D9TJZ7
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS06650
gene id: 608506:COB47_RS06650
uniprot id: D9TKS9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

608506:COB47 RS02570
gene id: 608506:COB47_RS02570
uniprot id: D9TIK8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

608506:COB47 RS08940
gene id: 608506:COB47_RS08940
uniprot id: D9TFT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

608506:COB47 RS04990
gene id: 608506:COB47_RS04990
uniprot id: D9TJW4
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

608506:COB47 RS00405
gene id: 608506:COB47_RS00405
uniprot id: D9TH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02010
gene id: 608506:COB47_RS02010
uniprot id: D9TIB1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

608506:COB47 RS01755
gene id: 608506:COB47_RS01755
uniprot id: D9TI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS11930
gene id: 608506:COB47_RS11930
uniprot id: D9TJY9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

608506:COB47 RS07475
gene id: 608506:COB47_RS07475
uniprot id: D9TL93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

608506:COB47 RS03695
gene id: 608506:COB47_RS03695
uniprot id: D9TJ75
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07895
gene id: 608506:COB47_RS07895
uniprot id: D9TF87
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS11485
gene id: 608506:COB47_RS11485
uniprot id: D9THP1
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

608506:COB47 RS08325
gene id: 608506:COB47_RS08325
uniprot id: D9TFH1
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

608506:COB47 RS08250
gene id: 608506:COB47_RS08250
uniprot id: D9TFF6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

608506:COB47 RS04080
gene id: 608506:COB47_RS04080
uniprot id: D9TJF0
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS06300
gene id: 608506:COB47_RS06300
uniprot id: D9TKL0
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

608506:COB47 RS10925
gene id: 608506:COB47_RS10925
uniprot id: D9TH24
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04360
gene id: 608506:COB47_RS04360
uniprot id: D9TJK1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

608506:COB47 RS07040
gene id: 608506:COB47_RS07040
uniprot id: D9TL07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

608506:COB47 RS04765
gene id: 608506:COB47_RS04765
uniprot id: D9TJS0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

608506:COB47 RS03965
gene id: 608506:COB47_RS03965
uniprot id: D9TJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

608506:COB47 RS01080
gene id: 608506:COB47_RS01080
uniprot id: D9THL1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS08880
gene id: 608506:COB47_RS08880
uniprot id: D9TFS8
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

608506:COB47 RS11195
gene id: 608506:COB47_RS11195
uniprot id: D9TH68
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS08105
gene id: 608506:COB47_RS08105
uniprot id: D9TFC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

608506:COB47 RS02730
gene id: 608506:COB47_RS02730
uniprot id: D9TIN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

608506:COB47 RS06425
gene id: 608506:COB47_RS06425
uniprot id: D9TKN4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608506:COB47 RS05215
gene id: 608506:COB47_RS05215
uniprot id: D9TK06
names: Similarity
messages: Belongs to the UPF0047 family.

608506:COB47 RS08545
gene id: 608506:COB47_RS08545
uniprot id: D9TFL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

608506:COB47 RS07805
gene id: 608506:COB47_RS07805
uniprot id: D9TLF8
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

608506:COB47 RS06260
gene id: 608506:COB47_RS06260
uniprot id: D9TKK2
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

608506:COB47 RS06540
gene id: 608506:COB47_RS06540
uniprot id: D9TKQ7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

608506:COB47 RS07085
gene id: 608506:COB47_RS07085
uniprot id: D9TL16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

608506:COB47 RS04720
gene id: 608506:COB47_RS04720
uniprot id: D9TJR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

608506:COB47 RS02595
gene id: 608506:COB47_RS02595
uniprot id: D9TIL3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS11725
gene id: 608506:COB47_RS11725
uniprot id: D9THT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

608506:COB47 RS02385
gene id: 608506:COB47_RS02385
uniprot id: D9TIH6
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS06645
gene id: 608506:COB47_RS06645
uniprot id: D9TKS8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

608506:COB47 RS02680
gene id: 608506:COB47_RS02680
uniprot id: D9TIM9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

608506:COB47 RS10680
gene id: 608506:COB47_RS10680
uniprot id: D9TGY3
names: Similarity
messages: Belongs to the glutamate synthase family.

608506:COB47 RS03015
gene id: 608506:COB47_RS03015
uniprot id: D9TIU7
names: Similarity
messages: Belongs to the threonine synthase family.

608506:COB47 RS07070
gene id: 608506:COB47_RS07070
uniprot id: D9TL13
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS07940
gene id: 608506:COB47_RS07940
uniprot id: D9TF94
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

608506:COB47 RS06325
gene id: 608506:COB47_RS06325
uniprot id: D9TKL5
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

608506:COB47 RS05595
gene id: 608506:COB47_RS05595
uniprot id: D9TK75
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS11420
gene id: 608506:COB47_RS11420
uniprot id: D9THM9
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

608506:COB47 RS11120
gene id: 608506:COB47_RS11120
uniprot id: D9TH54
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS09730
gene id: 608506:COB47_RS09730
uniprot id: D9TG90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

608506:COB47 RS10380
gene id: 608506:COB47_RS10380
uniprot id: D9TGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

608506:COB47 RS01665
gene id: 608506:COB47_RS01665
uniprot id: D9TI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

608506:COB47 RS06310
gene id: 608506:COB47_RS06310
uniprot id: D9TKL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

608506:COB47 RS04470
gene id: 608506:COB47_RS04470
uniprot id: D9TJL9
names: Similarity
messages: Belongs to the TrpC family.

608506:COB47 RS10430
gene id: 608506:COB47_RS10430
uniprot id: D9TGL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02480
gene id: 608506:COB47_RS02480
uniprot id: D9TIJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

608506:COB47 RS08175
gene id: 608506:COB47_RS08175
uniprot id: D9TFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

608506:COB47 RS00520
gene id: 608506:COB47_RS00520
uniprot id: D9THB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

608506:COB47 RS02510
gene id: 608506:COB47_RS02510
uniprot id: D9TIK0
names: Function
names: Similarity
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

608506:COB47 RS09400
gene id: 608506:COB47_RS09400
uniprot id: D9TG22
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

608506:COB47 RS05465
gene id: 608506:COB47_RS05465
uniprot id: D9TK49
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

608506:COB47 RS01310
gene id: 608506:COB47_RS01310
uniprot id: D9THY7
names: Similarity
messages: Belongs to the ComB family.

608506:COB47 RS04340
gene id: 608506:COB47_RS04340
uniprot id: D9TJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

608506:COB47 RS04175
gene id: 608506:COB47_RS04175
uniprot id: D9TJG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

608506:COB47 RS05955
gene id: 608506:COB47_RS05955
uniprot id: D9TKE6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

608506:COB47 RS06735
gene id: 608506:COB47_RS06735
uniprot id: D9TKU6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

608506:COB47 RS09685
gene id: 608506:COB47_RS09685
uniprot id: D9TG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

608506:COB47 RS00090
gene id: 608506:COB47_RS00090
uniprot id: D9TGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

608506:COB47 RS02230
gene id: 608506:COB47_RS02230
uniprot id: D9TIE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

608506:COB47 RS08930
gene id: 608506:COB47_RS08930
uniprot id: D9TFT6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

608506:COB47 RS00860
gene id: 608506:COB47_RS00860
uniprot id: D9THH0
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS09530
gene id: 608506:COB47_RS09530
uniprot id: D9TG51
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

608506:COB47 RS07255
gene id: 608506:COB47_RS07255
uniprot id: D9TL50
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS04290
gene id: 608506:COB47_RS04290
uniprot id: D9TJI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

608506:COB47 RS00950
gene id: 608506:COB47_RS00950
uniprot id: D9THI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS06115
gene id: 608506:COB47_RS06115
uniprot id: D9TKH1
names: Similarity
messages: Belongs to the YggT family.

608506:COB47 RS10195
gene id: 608506:COB47_RS10195
uniprot id: D9TGH4
names: Similarity
messages: Belongs to the universal stress protein A family.

608506:COB47 RS08805
gene id: 608506:COB47_RS08805
uniprot id: D9TFR3
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

608506:COB47 RS10755
gene id: 608506:COB47_RS10755
uniprot id: D9TGZ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

608506:COB47 RS10580
gene id: 608506:COB47_RS10580
uniprot id: D9TGP2
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

608506:COB47 RS06910
gene id: 608506:COB47_RS06910
uniprot id: D9TKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

608506:COB47 RS10730
gene id: 608506:COB47_RS10730
uniprot id: D9TGZ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS02635
gene id: 608506:COB47_RS02635
uniprot id: D9TIM0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS10400
gene id: 608506:COB47_RS10400
uniprot id: D9TGL2
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

608506:COB47 RS01580
gene id: 608506:COB47_RS01580
uniprot id: D9TI36
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS10860
gene id: 608506:COB47_RS10860
uniprot id: D9TH14
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

608506:COB47 RS09165
gene id: 608506:COB47_RS09165
uniprot id: D9TFY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS03890
gene id: 608506:COB47_RS03890
uniprot id: D9TJB3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

608506:COB47 RS00295
gene id: 608506:COB47_RS00295
uniprot id: D9TGV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

608506:COB47 RS04610
gene id: 608506:COB47_RS04610
uniprot id: D9TJP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

608506:COB47 RS01645
gene id: 608506:COB47_RS01645
uniprot id: D9TI49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

608506:COB47 RS00885
gene id: 608506:COB47_RS00885
uniprot id: D9THH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

608506:COB47 RS06390
gene id: 608506:COB47_RS06390
uniprot id: D9TKM8
names: Similarity
messages: Belongs to the TlyA family.

608506:COB47 RS09915
gene id: 608506:COB47_RS09915
uniprot id: D9TGC3
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

608506:COB47 RS01005
gene id: 608506:COB47_RS01005
uniprot id: D9THJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS08150
gene id: 608506:COB47_RS08150
uniprot id: D9TFD6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS03700
gene id: 608506:COB47_RS03700
uniprot id: D9TJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

608506:COB47 RS07740
gene id: 608506:COB47_RS07740
uniprot id: D9TLE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

608506:COB47 RS11505
gene id: 608506:COB47_RS11505
uniprot id: D9THP3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608506:COB47 RS07280
gene id: 608506:COB47_RS07280
uniprot id: D9TL55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

608506:COB47 RS07310
gene id: 608506:COB47_RS07310
uniprot id: D9TL61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

608506:COB47 RS09695
gene id: 608506:COB47_RS09695
uniprot id: D9TG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

608506:COB47 RS11455
gene id: 608506:COB47_RS11455
uniprot id: D9THN5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

608506:COB47 RS08595
gene id: 608506:COB47_RS08595
uniprot id: D9TFM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

608506:COB47 RS06190
gene id: 608506:COB47_RS06190
uniprot id: D9TKI6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

608506:COB47 RS08070
gene id: 608506:COB47_RS08070
uniprot id: D9TFC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

608506:COB47 RS04010
gene id: 608506:COB47_RS04010
uniprot id: D9TJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07515
gene id: 608506:COB47_RS07515
uniprot id: D9TLA1
names: Similarity
messages: Belongs to the histone deacetylase family.

608506:COB47 RS06815
gene id: 608506:COB47_RS06815
uniprot id: D9TKW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

608506:COB47 RS08160
gene id: 608506:COB47_RS08160
uniprot id: D9TFD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

608506:COB47 RS05915
gene id: 608506:COB47_RS05915
uniprot id: D9TKD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

608506:COB47 RS03450
gene id: 608506:COB47_RS03450
uniprot id: D9TJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

608506:COB47 RS03200
gene id: 608506:COB47_RS03200
uniprot id: D9TIY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

608506:COB47 RS05080
gene id: 608506:COB47_RS05080
uniprot id: D9TJY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

608506:COB47 RS07550
gene id: 608506:COB47_RS07550
uniprot id: D9TLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07680
gene id: 608506:COB47_RS07680
uniprot id: D9TLD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

608506:COB47 RS04675
gene id: 608506:COB47_RS04675
uniprot id: D9TJQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

608506:COB47 RS11745
gene id: 608506:COB47_RS11745
uniprot id: D9THU0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

608506:COB47 RS03985
gene id: 608506:COB47_RS03985
uniprot id: D9TJD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

608506:COB47 RS10295
gene id: 608506:COB47_RS10295
uniprot id: D9TGJ1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608506:COB47 RS06675
gene id: 608506:COB47_RS06675
uniprot id: D9TKT4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

608506:COB47 RS06925
gene id: 608506:COB47_RS06925
uniprot id: D9TKY2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

608506:COB47 RS11460
gene id: 608506:COB47_RS11460
uniprot id: D9THN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

608506:COB47 RS07775
gene id: 608506:COB47_RS07775
uniprot id: D9TLF2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

608506:COB47 RS07470
gene id: 608506:COB47_RS07470
uniprot id: D9TL92
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

608506:COB47 RS04170
gene id: 608506:COB47_RS04170
uniprot id: D9TJG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

608506:COB47 RS08280
gene id: 608506:COB47_RS08280
uniprot id: D9TFG2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

608506:COB47 RS06205
gene id: 608506:COB47_RS06205
uniprot id: D9TKJ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

608506:COB47 RS04835
gene id: 608506:COB47_RS04835
uniprot id: D9TJT6
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

608506:COB47 RS07505
gene id: 608506:COB47_RS07505
uniprot id: D9TL99
names: Similarity
messages: Belongs to the YicC/YloC family.

608506:COB47 RS09585
gene id: 608506:COB47_RS09585
uniprot id: D9TG62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS11165
gene id: 608506:COB47_RS11165
uniprot id: D9TH63
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

608506:COB47 RS08480
gene id: 608506:COB47_RS08480
uniprot id: D9TFK0
names: Similarity
messages: Belongs to the GSP E family.

608506:COB47 RS08835
gene id: 608506:COB47_RS08835
uniprot id: D9TFR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS07155
gene id: 608506:COB47_RS07155
uniprot id: D9TL30
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

608506:COB47 RS06700
gene id: 608506:COB47_RS06700
uniprot id: D9TKT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

608506:COB47 RS05695
gene id: 608506:COB47_RS05695
uniprot id: D9TK95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

608506:COB47 RS03010
gene id: 608506:COB47_RS03010
uniprot id: D9TIU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

608506:COB47 RS03065
gene id: 608506:COB47_RS03065
uniprot id: D9TIV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00955
gene id: 608506:COB47_RS00955
uniprot id: D9THI9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS05950
gene id: 608506:COB47_RS05950
uniprot id: D9TKE5
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

608506:COB47 RS07995
gene id: 608506:COB47_RS07995
uniprot id: D9TFA5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS09440
gene id: 608506:COB47_RS09440
uniprot id: D9TG30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

608506:COB47 RS05530
gene id: 608506:COB47_RS05530
uniprot id: D9TK62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

608506:COB47 RS11100
gene id: 608506:COB47_RS11100
uniprot id: D9TH50
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

608506:COB47 RS04565
gene id: 608506:COB47_RS04565
uniprot id: D9TJN6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

608506:COB47 RS04300
gene id: 608506:COB47_RS04300
uniprot id: D9TJJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

608506:COB47 RS11715
gene id: 608506:COB47_RS11715
uniprot id: D9THT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

608506:COB47 RS10420
gene id: 608506:COB47_RS10420
uniprot id: D9TGL4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

608506:COB47 RS09550
gene id: 608506:COB47_RS09550
uniprot id: D9TG55
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS04065
gene id: 608506:COB47_RS04065
uniprot id: D9TJE7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS05685
gene id: 608506:COB47_RS05685
uniprot id: D9TK93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

608506:COB47 RS06525
gene id: 608506:COB47_RS06525
uniprot id: D9TKQ4
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

608506:COB47 RS10525
gene id: 608506:COB47_RS10525
uniprot id: D9TGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02850
gene id: 608506:COB47_RS02850
uniprot id: D9TIR3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608506:COB47 RS03835
gene id: 608506:COB47_RS03835
uniprot id: D9TJA2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS00355
gene id: 608506:COB47_RS00355
uniprot id: D9TGW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS08865
gene id: 608506:COB47_RS08865
uniprot id: D9TFS5
names: Similarity
messages: Belongs to the UPF0735 family.

608506:COB47 RS09870
gene id: 608506:COB47_RS09870
uniprot id: D9TGB7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

608506:COB47 RS06575
gene id: 608506:COB47_RS06575
uniprot id: D9TKR4
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

608506:COB47 RS01615
gene id: 608506:COB47_RS01615
uniprot id: D9TI43
names: Function
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

608506:COB47 RS03535
gene id: 608506:COB47_RS03535
uniprot id: D9TJ43
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

608506:COB47 RS07780
gene id: 608506:COB47_RS07780
uniprot id: D9TLF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

608506:COB47 RS04145
gene id: 608506:COB47_RS04145
uniprot id: D9TJF9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

608506:COB47 RS05710
gene id: 608506:COB47_RS05710
uniprot id: D9TK98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

608506:COB47 RS01020
gene id: 608506:COB47_RS01020
uniprot id: D9THK0
names: Similarity
messages: Belongs to the DHPS family.

608506:COB47 RS02820
gene id: 608506:COB47_RS02820
uniprot id: D9TIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02845
gene id: 608506:COB47_RS02845
uniprot id: D9TIR2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

608506:COB47 RS06770
gene id: 608506:COB47_RS06770
uniprot id: D9TKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

608506:COB47 RS05460
gene id: 608506:COB47_RS05460
uniprot id: D9TK48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

608506:COB47 RS01995
gene id: 608506:COB47_RS01995
uniprot id: D9TIA9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

608506:COB47 RS10055
gene id: 608506:COB47_RS10055
uniprot id: D9TGE7
names: Similarity
messages: Belongs to the ribulokinase family.

608506:COB47 RS06900
gene id: 608506:COB47_RS06900
uniprot id: D9TKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

608506:COB47 RS03950
gene id: 608506:COB47_RS03950
uniprot id: D9TJC5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS03585
gene id: 608506:COB47_RS03585
uniprot id: D9TJ53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

608506:COB47 RS10090
gene id: 608506:COB47_RS10090
uniprot id: D9TGF3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04055
gene id: 608506:COB47_RS04055
uniprot id: D9TJE5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

608506:COB47 RS04710
gene id: 608506:COB47_RS04710
uniprot id: D9TJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

608506:COB47 RS08475
gene id: 608506:COB47_RS08475
uniprot id: D9TFJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS03250
gene id: 608506:COB47_RS03250
uniprot id: D9TIZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

608506:COB47 RS01765
gene id: 608506:COB47_RS01765
uniprot id: D9TI67
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

608506:COB47 RS08855
gene id: 608506:COB47_RS08855
uniprot id: D9TFS3
names: Similarity
messages: Belongs to the GerABKA family.

608506:COB47 RS00805
gene id: 608506:COB47_RS00805
uniprot id: D9THG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

608506:COB47 RS07025
gene id: 608506:COB47_RS07025
uniprot id: D9TL03
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS06590
gene id: 608506:COB47_RS06590
uniprot id: D9TKR7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00490
gene id: 608506:COB47_RS00490
uniprot id: D9THA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

608506:COB47 RS03660
gene id: 608506:COB47_RS03660
uniprot id: D9TJ68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

608506:COB47 RS01200
gene id: 608506:COB47_RS01200
uniprot id: D9THW8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS05350
gene id: 608506:COB47_RS05350
uniprot id: D9TK26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

608506:COB47 RS08850
gene id: 608506:COB47_RS08850
uniprot id: D9TFS2
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

608506:COB47 RS08000
gene id: 608506:COB47_RS08000
uniprot id: D9TFA6
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS10585
gene id: 608506:COB47_RS10585
uniprot id: D9TGP3
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

608506:COB47 RS05890
gene id: 608506:COB47_RS05890
uniprot id: D9TKD3
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02675
gene id: 608506:COB47_RS02675
uniprot id: D9TIM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608506:COB47 RS01880
gene id: 608506:COB47_RS01880
uniprot id: D9TI89
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

608506:COB47 RS05755
gene id: 608506:COB47_RS05755
uniprot id: D9TKA7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS09865
gene id: 608506:COB47_RS09865
uniprot id: D9TGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS09605
gene id: 608506:COB47_RS09605
uniprot id: D9TG66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

608506:COB47 RS07750
gene id: 608506:COB47_RS07750
uniprot id: D9TLE7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

608506:COB47 RS06010
gene id: 608506:COB47_RS06010
uniprot id: D9TKF3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

608506:COB47 RS11735
gene id: 608506:COB47_RS11735
uniprot id: D9THT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

608506:COB47 RS03160
gene id: 608506:COB47_RS03160
uniprot id: D9TIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

608506:COB47 RS05885
gene id: 608506:COB47_RS05885
uniprot id: D9TKD2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07090
gene id: 608506:COB47_RS07090
uniprot id: D9TL17
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

608506:COB47 RS08155
gene id: 608506:COB47_RS08155
uniprot id: D9TFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

608506:COB47 RS11720
gene id: 608506:COB47_RS11720
uniprot id: D9THT5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS02700
gene id: 608506:COB47_RS02700
uniprot id: D9TIN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS10910
gene id: 608506:COB47_RS10910
uniprot id: D9TH22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS05675
gene id: 608506:COB47_RS05675
uniprot id: D9TK91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

608506:COB47 RS07685
gene id: 608506:COB47_RS07685
uniprot id: D9TLD4
names: Similarity
messages: Belongs to the CinA family.

608506:COB47 RS09415
gene id: 608506:COB47_RS09415
uniprot id: D9TG25
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS05770
gene id: 608506:COB47_RS05770
uniprot id: D9TKB0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

608506:COB47 RS01970
gene id: 608506:COB47_RS01970
uniprot id: D9TIA5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS03475
gene id: 608506:COB47_RS03475
uniprot id: D9TJ31
names: Similarity
messages: Belongs to the transpeptidase family.

608506:COB47 RS06625
gene id: 608506:COB47_RS06625
uniprot id: D9TKS4
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07285
gene id: 608506:COB47_RS07285
uniprot id: D9TL56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

608506:COB47 RS03510
gene id: 608506:COB47_RS03510
uniprot id: D9TJ38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS11365
gene id: 608506:COB47_RS11365
uniprot id: D9THM0
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

608506:COB47 RS02770
gene id: 608506:COB47_RS02770
uniprot id: D9TIP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

608506:COB47 RS05815
gene id: 608506:COB47_RS05815
uniprot id: D9TKB9
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS08025
gene id: 608506:COB47_RS08025
uniprot id: D9TFB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

608506:COB47 RS03145
gene id: 608506:COB47_RS03145
uniprot id: D9TIX2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05925
gene id: 608506:COB47_RS05925
uniprot id: D9TKE0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS07230
gene id: 608506:COB47_RS07230
uniprot id: D9TL45
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

608506:COB47 RS08210
gene id: 608506:COB47_RS08210
uniprot id: D9TFE8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

608506:COB47 RS09955
gene id: 608506:COB47_RS09955
uniprot id: D9TGD0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

608506:COB47 RS07060
gene id: 608506:COB47_RS07060
uniprot id: D9TL11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

608506:COB47 RS05905
gene id: 608506:COB47_RS05905
uniprot id: D9TKD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS04400
gene id: 608506:COB47_RS04400
uniprot id: D9TJK5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS06175
gene id: 608506:COB47_RS06175
uniprot id: D9TKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

608506:COB47 RS10700
gene id: 608506:COB47_RS10700
uniprot id: D9TGY6
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS00870
gene id: 608506:COB47_RS00870
uniprot id: D9THH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04205
gene id: 608506:COB47_RS04205
uniprot id: D9TJH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

608506:COB47 RS10510
gene id: 608506:COB47_RS10510
uniprot id: D9TGM8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

608506:COB47 RS07690
gene id: 608506:COB47_RS07690
uniprot id: D9TLD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

608506:COB47 RS06445
gene id: 608506:COB47_RS06445
uniprot id: D9TKN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

608506:COB47 RS04445
gene id: 608506:COB47_RS04445
uniprot id: D9TJL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

608506:COB47 RS09095
gene id: 608506:COB47_RS09095
uniprot id: D9TFW6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

608506:COB47 RS03845
gene id: 608506:COB47_RS03845
uniprot id: D9TJA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

608506:COB47 RS04005
gene id: 608506:COB47_RS04005
uniprot id: D9TJD5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00240
gene id: 608506:COB47_RS00240
uniprot id: D9TGT9
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02015
gene id: 608506:COB47_RS02015
uniprot id: D9TIB2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05565
gene id: 608506:COB47_RS05565
uniprot id: D9TK69
names: Similarity
messages: Belongs to the SAICAR synthetase family.

608506:COB47 RS04475
gene id: 608506:COB47_RS04475
uniprot id: D9TJM0
names: Similarity
messages: Belongs to the TrpF family.

608506:COB47 RS06680
gene id: 608506:COB47_RS06680
uniprot id: D9TKT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm

608506:COB47 RS00020
gene id: 608506:COB47_RS00020
uniprot id: D9TGP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

608506:COB47 RS04070
gene id: 608506:COB47_RS04070
uniprot id: D9TJE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

608506:COB47 RS03245
gene id: 608506:COB47_RS03245
uniprot id: D9TIZ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

608506:COB47 RS06055
gene id: 608506:COB47_RS06055
uniprot id: D9TKG0
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

608506:COB47 RS00410
gene id: 608506:COB47_RS00410
uniprot id: D9TH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05945
gene id: 608506:COB47_RS05945
uniprot id: D9TKE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

608506:COB47 RS03635
gene id: 608506:COB47_RS03635
uniprot id: D9TJ63
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

608506:COB47 RS04315
gene id: 608506:COB47_RS04315
uniprot id: D9TJJ4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

608506:COB47 RS11240
gene id: 608506:COB47_RS11240
uniprot id: D9TH77
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05605
gene id: 608506:COB47_RS05605
uniprot id: D9TK77
names: Similarity
messages: Belongs to the GARS family.

608506:COB47 RS06840
gene id: 608506:COB47_RS06840
uniprot id: D9TKW7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

608506:COB47 RS05015
gene id: 608506:COB47_RS05015
uniprot id: D9TJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

608506:COB47 RS09790
gene id: 608506:COB47_RS09790
uniprot id: D9TGA2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

608506:COB47 RS11760
gene id: 608506:COB47_RS11760
uniprot id: D9THU3
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

608506:COB47 RS02250
gene id: 608506:COB47_RS02250
uniprot id: D9TIF0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

608506:COB47 RS03850
gene id: 608506:COB47_RS03850
uniprot id: D9TJA5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

608506:COB47 RS11025
gene id: 608506:COB47_RS11025
uniprot id: D9TH40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

608506:COB47 RS04530
gene id: 608506:COB47_RS04530
uniprot id: D9TJM9
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

608506:COB47 RS10920
gene id: 608506:COB47_RS10920
uniprot id: D9TH23
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

608506:COB47 RS07250
gene id: 608506:COB47_RS07250
uniprot id: D9TL49
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

608506:COB47 RS10655
gene id: 608506:COB47_RS10655
uniprot id: D9TGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

608506:COB47 RS04510
gene id: 608506:COB47_RS04510
uniprot id: D9TJM7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS07425
gene id: 608506:COB47_RS07425
uniprot id: D9TL83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

608506:COB47 RS09255
gene id: 608506:COB47_RS09255
uniprot id: D9TFZ9
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

608506:COB47 RS04075
gene id: 608506:COB47_RS04075
uniprot id: D9TJE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00255
gene id: 608506:COB47_RS00255
uniprot id: D9TGU2
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

608506:COB47 RS02095
gene id: 608506:COB47_RS02095
uniprot id: D9TIC7
names: Similarity
messages: Belongs to the glycosyl hydrolase.

608506:COB47 RS09235
gene id: 608506:COB47_RS09235
uniprot id: D9TFZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04480
gene id: 608506:COB47_RS04480
uniprot id: D9TJM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

608506:COB47 RS04350
gene id: 608506:COB47_RS04350
uniprot id: D9TJJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS09085
gene id: 608506:COB47_RS09085
uniprot id: D9TFW4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

608506:COB47 RS02950
gene id: 608506:COB47_RS02950
uniprot id: D9TIT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

608506:COB47 RS09140
gene id: 608506:COB47_RS09140
uniprot id: D9TFX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

608506:COB47 RS05575
gene id: 608506:COB47_RS05575
uniprot id: D9TK71
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

608506:COB47 RS02505
gene id: 608506:COB47_RS02505
uniprot id: D9TIJ9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

608506:COB47 RS01930
gene id: 608506:COB47_RS01930
uniprot id: D9TI99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

608506:COB47 RS09425
gene id: 608506:COB47_RS09425
uniprot id: D9TG27
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

608506:COB47 RS01050
gene id: 608506:COB47_RS01050
uniprot id: D9THK5
names: Similarity
messages: Belongs to the PspA/IM30 family.

608506:COB47 RS08215
gene id: 608506:COB47_RS08215
uniprot id: D9TFE9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

608506:COB47 RS03035
gene id: 608506:COB47_RS03035
uniprot id: D9TIV1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS06345
gene id: 608506:COB47_RS06345
uniprot id: D9TKL9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

608506:COB47 RS01095
gene id: 608506:COB47_RS01095
uniprot id: D9THU7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608506:COB47 RS09115
gene id: 608506:COB47_RS09115
uniprot id: D9TFX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

608506:COB47 RS07620
gene id: 608506:COB47_RS07620
uniprot id: D9TLC1
names: Similarity
messages: Belongs to the asp23 family.

608506:COB47 RS04050
gene id: 608506:COB47_RS04050
uniprot id: D9TJE4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

608506:COB47 RS07820
gene id: 608506:COB47_RS07820
uniprot id: D9TLG1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

608506:COB47 RS02685
gene id: 608506:COB47_RS02685
uniprot id: D9TIN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS06795
gene id: 608506:COB47_RS06795
uniprot id: D9TKV8
names: Similarity
messages: Belongs to the UPF0297 family.

608506:COB47 RS07390
gene id: 608506:COB47_RS07390
uniprot id: D9TL76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

608506:COB47 RS04485
gene id: 608506:COB47_RS04485
uniprot id: D9TJM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

608506:COB47 RS08205
gene id: 608506:COB47_RS08205
uniprot id: D9TFE7
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02830
gene id: 608506:COB47_RS02830
uniprot id: D9TIQ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

608506:COB47 RS07585
gene id: 608506:COB47_RS07585
uniprot id: D9TLB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

608506:COB47 RS11320
gene id: 608506:COB47_RS11320
uniprot id: D9THL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

608506:COB47 RS09185
gene id: 608506:COB47_RS09185
uniprot id: D9TFY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

608506:COB47 RS07110
gene id: 608506:COB47_RS07110
uniprot id: D9TL21
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

608506:COB47 RS09850
gene id: 608506:COB47_RS09850
uniprot id: D9TGB3
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

608506:COB47 RS02910
gene id: 608506:COB47_RS02910
uniprot id: D9TIS6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

608506:COB47 RS04320
gene id: 608506:COB47_RS04320
uniprot id: D9TJJ5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

608506:COB47 RS10785
gene id: 608506:COB47_RS10785
uniprot id: D9TH00
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

608506:COB47 RS07485
gene id: 608506:COB47_RS07485
uniprot id: D9TL95
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS02825
gene id: 608506:COB47_RS02825
uniprot id: D9TIQ8
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

608506:COB47 RS11705
gene id: 608506:COB47_RS11705
uniprot id: D9THT2
names: Similarity
messages: Belongs to the ParB family.

608506:COB47 RS04355
gene id: 608506:COB47_RS04355
uniprot id: D9TJK0
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

608506:COB47 RS05320
gene id: 608506:COB47_RS05320
uniprot id: D9TK20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS03785
gene id: 608506:COB47_RS03785
uniprot id: D9TJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05325
gene id: 608506:COB47_RS05325
uniprot id: D9TK21
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

608506:COB47 RS00600
gene id: 608506:COB47_RS00600
uniprot id: D9THC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

608506:COB47 RS11750
gene id: 608506:COB47_RS11750
uniprot id: D9THU1
names: Similarity
messages: Belongs to the GerABKA family.

608506:COB47 RS06965
gene id: 608506:COB47_RS06965
uniprot id: D9TKZ0
names: Similarity
messages: Belongs to the UPF0473 family.

608506:COB47 RS04100
gene id: 608506:COB47_RS04100
uniprot id: D9TJF2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS10000
gene id: 608506:COB47_RS10000
uniprot id: D9TGD8
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

608506:COB47 RS09725
gene id: 608506:COB47_RS09725
uniprot id: D9TG89
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

608506:COB47 RS07065
gene id: 608506:COB47_RS07065
uniprot id: D9TL12
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

608506:COB47 RS06315
gene id: 608506:COB47_RS06315
uniprot id: D9TKL3
names: Similarity
messages: Belongs to the class-D beta-lactamase family.
messages: Belongs to the transpeptidase family.

608506:COB47 RS04210
gene id: 608506:COB47_RS04210
uniprot id: D9TJH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

608506:COB47 RS02070
gene id: 608506:COB47_RS02070
uniprot id: D9TIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

608506:COB47 RS09765
gene id: 608506:COB47_RS09765
uniprot id: D9TG97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS01900
gene id: 608506:COB47_RS01900
uniprot id: D9TI93
names: Similarity
messages: Belongs to the sigma-70 factor family.

608506:COB47 RS07745
gene id: 608506:COB47_RS07745
uniprot id: D9TLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

608506:COB47 RS07215
gene id: 608506:COB47_RS07215
uniprot id: D9TL42
names: Similarity
messages: Belongs to the HupF/HypC family.

608506:COB47 RS00535
gene id: 608506:COB47_RS00535
uniprot id: D9THB3
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS11520
gene id: 608506:COB47_RS11520
uniprot id: D9THP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

608506:COB47 RS06215
gene id: 608506:COB47_RS06215
uniprot id: D9TKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

608506:COB47 RS09925
gene id: 608506:COB47_RS09925
uniprot id: D9TGC5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

608506:COB47 RS08330
gene id: 608506:COB47_RS08330
uniprot id: D9TFH2
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

608506:COB47 RS07315
gene id: 608506:COB47_RS07315
uniprot id: D9TL62
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

608506:COB47 RS05800
gene id: 608506:COB47_RS05800
uniprot id: D9TKB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

608506:COB47 RS05930
gene id: 608506:COB47_RS05930
uniprot id: D9TKE1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

608506:COB47 RS08950
gene id: 608506:COB47_RS08950
uniprot id: D9TFU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

608506:COB47 RS01300
gene id: 608506:COB47_RS01300
uniprot id: D9THY5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS05455
gene id: 608506:COB47_RS05455
uniprot id: D9TK47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

608506:COB47 RS08110
gene id: 608506:COB47_RS08110
uniprot id: D9TFC8
names: Similarity
messages: Belongs to the CdaR family.

608506:COB47 RS01385
gene id: 608506:COB47_RS01385
uniprot id: D9TI02
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

608506:COB47 RS09500
gene id: 608506:COB47_RS09500
uniprot id: D9TG45
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

608506:COB47 RS02415
gene id: 608506:COB47_RS02415
uniprot id: D9TII1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS00690
gene id: 608506:COB47_RS00690
uniprot id: D9THE0
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

608506:COB47 RS04930
gene id: 608506:COB47_RS04930
uniprot id: D9TJV2
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

608506:COB47 RS07955
gene id: 608506:COB47_RS07955
uniprot id: D9TF97
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS00945
gene id: 608506:COB47_RS00945
uniprot id: D9THI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS00580
gene id: 608506:COB47_RS00580
uniprot id: D9THC2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

608506:COB47 RS04280
gene id: 608506:COB47_RS04280
uniprot id: D9TJI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

608506:COB47 RS10095
gene id: 608506:COB47_RS10095
uniprot id: D9TGF4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

608506:COB47 RS07900
gene id: 608506:COB47_RS07900
uniprot id: D9TF88
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07140
gene id: 608506:COB47_RS07140
uniprot id: D9TL27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

608506:COB47 RS03665
gene id: 608506:COB47_RS03665
uniprot id: D9TJ69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

608506:COB47 RS01545
gene id: 608506:COB47_RS01545
uniprot id: D9TI29
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

608506:COB47 RS00360
gene id: 608506:COB47_RS00360
uniprot id: D9TGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS10595
gene id: 608506:COB47_RS10595
uniprot id: D9TGP4
names: Similarity
messages: Belongs to the peptidase S41A family.

608506:COB47 RS11205
gene id: 608506:COB47_RS11205
uniprot id: D9TH70
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS09960
gene id: 608506:COB47_RS09960
uniprot id: D9TGD1
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

608506:COB47 RS08020
gene id: 608506:COB47_RS08020
uniprot id: D9TFB0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

608506:COB47 RS05090
gene id: 608506:COB47_RS05090
uniprot id: D9TJY3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

608506:COB47 RS04265
gene id: 608506:COB47_RS04265
uniprot id: D9TJI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

608506:COB47 RS11295
gene id: 608506:COB47_RS11295
uniprot id: D9TH86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

608506:COB47 RS03580
gene id: 608506:COB47_RS03580
uniprot id: D9TJ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS08935
gene id: 608506:COB47_RS08935
uniprot id: D9TFT7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

608506:COB47 RS09785
gene id: 608506:COB47_RS09785
uniprot id: D9TGA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

608506:COB47 RS00900
gene id: 608506:COB47_RS00900
uniprot id: D9THH8
names: Similarity
messages: Belongs to the RutC family.

608506:COB47 RS06510
gene id: 608506:COB47_RS06510
uniprot id: D9TKQ1
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

608506:COB47 RS08460
gene id: 608506:COB47_RS08460
uniprot id: D9TFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

608506:COB47 RS07675
gene id: 608506:COB47_RS07675
uniprot id: D9TLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

608506:COB47 RS03155
gene id: 608506:COB47_RS03155
uniprot id: D9TIX4
names: Similarity
messages: Belongs to the UPF0342 family.

608506:COB47 RS11280
gene id: 608506:COB47_RS11280
uniprot id: D9TH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04695
gene id: 608506:COB47_RS04695
uniprot id: D9TJQ8
names: Subcellular Location Annotation
messages: Cell membrane

608506:COB47 RS06360
gene id: 608506:COB47_RS06360
uniprot id: D9TKM2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

608506:COB47 RS07455
gene id: 608506:COB47_RS07455
uniprot id: D9TL89
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

608506:COB47 RS04195
gene id: 608506:COB47_RS04195
uniprot id: D9TJH0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

608506:COB47 RS00195
gene id: 608506:COB47_RS00195
uniprot id: D9TGT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

608506:COB47 RS00765
gene id: 608506:COB47_RS00765
uniprot id: D9THF4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

608506:COB47 RS06415
gene id: 608506:COB47_RS06415
uniprot id: D9TKN2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

608506:COB47 RS05555
gene id: 608506:COB47_RS05555
uniprot id: D9TK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

608506:COB47 RS06905
gene id: 608506:COB47_RS06905
uniprot id: D9TKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

608506:COB47 RS11755
gene id: 608506:COB47_RS11755
uniprot id: D9THU2
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

608506:COB47 RS08010
gene id: 608506:COB47_RS08010
uniprot id: D9TFA8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

608506:COB47 RS01735
gene id: 608506:COB47_RS01735
uniprot id: D9TI61
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

608506:COB47 RS01015
gene id: 608506:COB47_RS01015
uniprot id: D9THJ9
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

608506:COB47 RS11170
gene id: 608506:COB47_RS11170
uniprot id: D9TH64
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

608506:COB47 RS05010
gene id: 608506:COB47_RS05010
uniprot id: D9TJW7
names: Similarity
messages: Belongs to the CapA family.

608506:COB47 RS08515
gene id: 608506:COB47_RS08515
uniprot id: D9TFK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

608506:COB47 RS06225
gene id: 608506:COB47_RS06225
uniprot id: D9TKJ4
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

608506:COB47 RS01640
gene id: 608506:COB47_RS01640
uniprot id: D9TI48
names: Similarity
messages: Belongs to the ThiD family.

608506:COB47 RS02930
gene id: 608506:COB47_RS02930
uniprot id: D9TIT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

608506:COB47 RS07570
gene id: 608506:COB47_RS07570
uniprot id: D9TLB1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

608506:COB47 RS01360
gene id: 608506:COB47_RS01360
uniprot id: D9THZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

608506:COB47 RS07005
gene id: 608506:COB47_RS07005
uniprot id: D9TKZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

608506:COB47 RS01125
gene id: 608506:COB47_RS01125
uniprot id: D9THV3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

608506:COB47 RS07240
gene id: 608506:COB47_RS07240
uniprot id: D9TL47
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Belongs to the complex I 49 kDa subunit family.

608506:COB47 RS03550
gene id: 608506:COB47_RS03550
uniprot id: D9TJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

608506:COB47 RS04700
gene id: 608506:COB47_RS04700
uniprot id: D9TJQ9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

608506:COB47 RS04240
gene id: 608506:COB47_RS04240
uniprot id: D9TJH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

608506:COB47 RS08285
gene id: 608506:COB47_RS08285
uniprot id: D9TFG3
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

608506:COB47 RS06725
gene id: 608506:COB47_RS06725
uniprot id: D9TKU4
names: Similarity
messages: Belongs to the asp23 family.

608506:COB47 RS11550
gene id: 608506:COB47_RS11550
uniprot id: D9THQ0
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS04235
gene id: 608506:COB47_RS04235
uniprot id: D9TJH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

608506:COB47 RS05735
gene id: 608506:COB47_RS05735
uniprot id: D9TKA3
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

608506:COB47 RS01830
gene id: 608506:COB47_RS01830
uniprot id: D9TI79
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

608506:COB47 RS09250
gene id: 608506:COB47_RS09250
uniprot id: D9TFZ8
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

608506:COB47 RS07415
gene id: 608506:COB47_RS07415
uniprot id: D9TL81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

608506:COB47 RS05430
gene id: 608506:COB47_RS05430
uniprot id: D9TK42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

608506:COB47 RS08670
gene id: 608506:COB47_RS08670
uniprot id: D9TFN8
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05040
gene id: 608506:COB47_RS05040
uniprot id: D9TJX3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

608506:COB47 RS05160
gene id: 608506:COB47_RS05160
uniprot id: D9TJZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

608506:COB47 RS09700
gene id: 608506:COB47_RS09700
uniprot id: D9TG84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

608506:COB47 RS07785
gene id: 608506:COB47_RS07785
uniprot id: D9TLF4
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

608506:COB47 RS03140
gene id: 608506:COB47_RS03140
uniprot id: D9TIX1
names: Similarity
messages: Belongs to the RecJ family.

608506:COB47 RS04410
gene id: 608506:COB47_RS04410
uniprot id: D9TJK7
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS00635
gene id: 608506:COB47_RS00635
uniprot id: D9THC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

608506:COB47 RS11020
gene id: 608506:COB47_RS11020
uniprot id: D9TH39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04295
gene id: 608506:COB47_RS04295
uniprot id: D9TJJ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

608506:COB47 RS06945
gene id: 608506:COB47_RS06945
uniprot id: D9TKY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

608506:COB47 RS08030
gene id: 608506:COB47_RS08030
uniprot id: D9TFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

608506:COB47 RS05795
gene id: 608506:COB47_RS05795
uniprot id: D9TKB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Monomer.

608506:COB47 RS02980
gene id: 608506:COB47_RS02980
uniprot id: D9TIU0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

608506:COB47 RS03495
gene id: 608506:COB47_RS03495
uniprot id: D9TJ35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

608506:COB47 RS07055
gene id: 608506:COB47_RS07055
uniprot id: D9TL10
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

608506:COB47 RS07275
gene id: 608506:COB47_RS07275
uniprot id: D9TL54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

608506:COB47 RS10995
gene id: 608506:COB47_RS10995
uniprot id: D9TH35
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608506:COB47 RS04140
gene id: 608506:COB47_RS04140
uniprot id: D9TJF8
names: Similarity
messages: Belongs to the peptidase M18 family.

608506:COB47 RS11495
gene id: 608506:COB47_RS11495
uniprot id: D9THP2
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

608506:COB47 RS02450
gene id: 608506:COB47_RS02450
uniprot id: D9TII8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

608506:COB47 RS10855
gene id: 608506:COB47_RS10855
uniprot id: D9TH13
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

608506:COB47 RS05330
gene id: 608506:COB47_RS05330
uniprot id: D9TK22
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

608506:COB47 RS05335
gene id: 608506:COB47_RS05335
uniprot id: D9TK23
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608506:COB47 RS10265
gene id: 608506:COB47_RS10265
uniprot id: D9TGI6
names: Similarity
messages: Belongs to the UPF0251 family.

608506:COB47 RS08260
gene id: 608506:COB47_RS08260
uniprot id: D9TFF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

608506:COB47 RS07480
gene id: 608506:COB47_RS07480
uniprot id: D9TL94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

608506:COB47 RS00430
gene id: 608506:COB47_RS00430
uniprot id: D9TH96
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

608506:COB47 RS04580
gene id: 608506:COB47_RS04580
uniprot id: D9TJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

608506:COB47 RS01320
gene id: 608506:COB47_RS01320
uniprot id: D9THY9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS07105
gene id: 608506:COB47_RS07105
uniprot id: D9TL20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS05095
gene id: 608506:COB47_RS05095
uniprot id: D9TJY4
names: Similarity
messages: Belongs to the asparagine synthetase family.

608506:COB47 RS07440
gene id: 608506:COB47_RS07440
uniprot id: D9TL86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

608506:COB47 RS03855
gene id: 608506:COB47_RS03855
uniprot id: D9TJA6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

608506:COB47 RS05285
gene id: 608506:COB47_RS05285
uniprot id: D9TK13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

608506:COB47 RS06765
gene id: 608506:COB47_RS06765
uniprot id: D9TKV2
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

608506:COB47 RS06420
gene id: 608506:COB47_RS06420
uniprot id: D9TKN3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608506:COB47 RS02220
gene id: 608506:COB47_RS02220
uniprot id: D9TIE3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

608506:COB47 RS07495
gene id: 608506:COB47_RS07495
uniprot id: D9TL97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

608506:COB47 RS03260
gene id: 608506:COB47_RS03260
uniprot id: D9TIZ5
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

608506:COB47 RS00200
gene id: 608506:COB47_RS00200
uniprot id: D9TGT4
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07560
gene id: 608506:COB47_RS07560
uniprot id: D9TLA9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

608506:COB47 RS11425
gene id: 608506:COB47_RS11425
uniprot id: D9THN0
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

608506:COB47 RS00250
gene id: 608506:COB47_RS00250
uniprot id: D9TGU1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

608506:COB47 RS05280
gene id: 608506:COB47_RS05280
uniprot id: D9TK12
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

608506:COB47 RS05590
gene id: 608506:COB47_RS05590
uniprot id: D9TK74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

608506:COB47 RS01370
gene id: 608506:COB47_RS01370
uniprot id: D9THZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

608506:COB47 RS05290
gene id: 608506:COB47_RS05290
uniprot id: D9TK14
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

608506:COB47 RS05635
gene id: 608506:COB47_RS05635
uniprot id: D9TK83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

608506:COB47 RS00980
gene id: 608506:COB47_RS00980
uniprot id: D9THJ3
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07360
gene id: 608506:COB47_RS07360
uniprot id: D9TL70
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

608506:COB47 RS03225
gene id: 608506:COB47_RS03225
uniprot id: D9TIY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

608506:COB47 RS11700
gene id: 608506:COB47_RS11700
uniprot id: D9THT1
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

608506:COB47 RS04435
gene id: 608506:COB47_RS04435
uniprot id: D9TJL2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608506:COB47 RS07435
gene id: 608506:COB47_RS07435
uniprot id: D9TL85
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

608506:COB47 RS02020
gene id: 608506:COB47_RS02020
uniprot id: D9TIB3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

608506:COB47 RS05105
gene id: 608506:COB47_RS05105
uniprot id: D9TJY5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

608506:COB47 RS08650
gene id: 608506:COB47_RS08650
uniprot id: D9TFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05790
gene id: 608506:COB47_RS05790
uniprot id: D9TKB4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

608506:COB47 RS05870
gene id: 608506:COB47_RS05870
uniprot id: D9TKC9
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

608506:COB47 RS11435
gene id: 608506:COB47_RS11435
uniprot id: D9THN2
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

608506:COB47 RS11695
gene id: 608506:COB47_RS11695
uniprot id: D9THT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

608506:COB47 RS09420
gene id: 608506:COB47_RS09420
uniprot id: D9TG26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

608506:COB47 RS10610
gene id: 608506:COB47_RS10610
uniprot id: D9TGX1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

608506:COB47 RS06600
gene id: 608506:COB47_RS06600
uniprot id: D9TKR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

608506:COB47 RS05840
gene id: 608506:COB47_RS05840
uniprot id: D9TKC4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

608506:COB47 RS09445
gene id: 608506:COB47_RS09445
uniprot id: D9TG31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

608506:COB47 RS04850
gene id: 608506:COB47_RS04850
uniprot id: D9TJT9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

608506:COB47 RS02360
gene id: 608506:COB47_RS02360
uniprot id: D9TIH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

608506:COB47 RS03530
gene id: 608506:COB47_RS03530
uniprot id: D9TJ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

608506:COB47 RS07825
gene id: 608506:COB47_RS07825
uniprot id: D9TLG2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

608506:COB47 RS07370
gene id: 608506:COB47_RS07370
uniprot id: D9TL72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS02045
gene id: 608506:COB47_RS02045
uniprot id: D9TIB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

608506:COB47 RS05190
gene id: 608506:COB47_RS05190
uniprot id: D9TK01
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

608506:COB47 RS04255
gene id: 608506:COB47_RS04255
uniprot id: D9TJI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

608506:COB47 RS08700
gene id: 608506:COB47_RS08700
uniprot id: D9TFP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

608506:COB47 RS10795
gene id: 608506:COB47_RS10795
uniprot id: D9TH02
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

608506:COB47 RS09815
gene id: 608506:COB47_RS09815
uniprot id: D9TGA7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

608506:COB47 RS00875
gene id: 608506:COB47_RS00875
uniprot id: D9THH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04495
gene id: 608506:COB47_RS04495
uniprot id: D9TJM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02780
gene id: 608506:COB47_RS02780
uniprot id: D9TIP9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

608506:COB47 RS01650
gene id: 608506:COB47_RS01650
uniprot id: D9TI50
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS10465
gene id: 608506:COB47_RS10465
uniprot id: D9TGM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

608506:COB47 RS07670
gene id: 608506:COB47_RS07670
uniprot id: D9TLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

608506:COB47 RS07210
gene id: 608506:COB47_RS07210
uniprot id: D9TL41
names: Similarity
messages: Belongs to the HypD family.

608506:COB47 RS09715
gene id: 608506:COB47_RS09715
uniprot id: D9TG87
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS03505
gene id: 608506:COB47_RS03505
uniprot id: D9TJ37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS06935
gene id: 608506:COB47_RS06935
uniprot id: D9TKY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

608506:COB47 RS03525
gene id: 608506:COB47_RS03525
uniprot id: D9TJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

608506:COB47 RS11730
gene id: 608506:COB47_RS11730
uniprot id: D9THT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

608506:COB47 RS07305
gene id: 608506:COB47_RS07305
uniprot id: D9TL60
names: Similarity
messages: Belongs to the MotB family.

608506:COB47 RS05545
gene id: 608506:COB47_RS05545
uniprot id: D9TK65
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04725
gene id: 608506:COB47_RS04725
uniprot id: D9TJR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07385
gene id: 608506:COB47_RS07385
uniprot id: D9TL75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

608506:COB47 RS03460
gene id: 608506:COB47_RS03460
uniprot id: D9TJ28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

608506:COB47 RS08140
gene id: 608506:COB47_RS08140
uniprot id: D9TFD4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

608506:COB47 RS03425
gene id: 608506:COB47_RS03425
uniprot id: D9TJ21
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

608506:COB47 RS08720
gene id: 608506:COB47_RS08720
uniprot id: D9TFP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

608506:COB47 RS06775
gene id: 608506:COB47_RS06775
uniprot id: D9TKV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

608506:COB47 RS00595
gene id: 608506:COB47_RS00595
uniprot id: D9THC5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

608506:COB47 RS04190
gene id: 608506:COB47_RS04190
uniprot id: D9TJG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

608506:COB47 RS11415
gene id: 608506:COB47_RS11415
uniprot id: D9THM8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

608506:COB47 RS02725
gene id: 608506:COB47_RS02725
uniprot id: D9TIN8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS03670
gene id: 608506:COB47_RS03670
uniprot id: D9TJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

608506:COB47 RS00775
gene id: 608506:COB47_RS00775
uniprot id: D9THF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

608506:COB47 RS00320
gene id: 608506:COB47_RS00320
uniprot id: D9TGV4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS10170
gene id: 608506:COB47_RS10170
uniprot id: D9TGG9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

608506:COB47 RS00530
gene id: 608506:COB47_RS00530
uniprot id: D9THB2
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS09265
gene id: 608506:COB47_RS09265
uniprot id: D9TG00
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

608506:COB47 RS10010
gene id: 608506:COB47_RS10010
uniprot id: D9TGE0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS10775
gene id: 608506:COB47_RS10775
uniprot id: D9TGZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

608506:COB47 RS10325
gene id: 608506:COB47_RS10325
uniprot id: D9TGJ8
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

608506:COB47 RS09275
gene id: 608506:COB47_RS09275
uniprot id: D9TG02
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

608506:COB47 RS01085
gene id: 608506:COB47_RS01085
uniprot id: D9THU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Monomer.

608506:COB47 RS06940
gene id: 608506:COB47_RS06940
uniprot id: D9TKY5
names: Similarity
messages: Belongs to the fabD family.

608506:COB47 RS09130
gene id: 608506:COB47_RS09130
uniprot id: D9TFX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

608506:COB47 RS05385
gene id: 608506:COB47_RS05385
uniprot id: D9TK34
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

608506:COB47 RS06565
gene id: 608506:COB47_RS06565
uniprot id: D9TKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

608506:COB47 RS05760
gene id: 608506:COB47_RS05760
uniprot id: D9TKA8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

608506:COB47 RS02475
gene id: 608506:COB47_RS02475
uniprot id: D9TIJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

608506:COB47 RS07355
gene id: 608506:COB47_RS07355
uniprot id: D9TL69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS07490
gene id: 608506:COB47_RS07490
uniprot id: D9TL96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

608506:COB47 RS09245
gene id: 608506:COB47_RS09245
uniprot id: D9TFZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

608506:COB47 RS02255
gene id: 608506:COB47_RS02255
uniprot id: D9TIF1
names: Similarity
messages: Belongs to the class-I fumarase family.

608506:COB47 RS00995
gene id: 608506:COB47_RS00995
uniprot id: D9THJ5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02460
gene id: 608506:COB47_RS02460
uniprot id: D9TIJ0
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

608506:COB47 RS11215
gene id: 608506:COB47_RS11215
uniprot id: D9TH72
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02870
gene id: 608506:COB47_RS02870
uniprot id: D9TIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

608506:COB47 RS05375
gene id: 608506:COB47_RS05375
uniprot id: D9TK31
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

608506:COB47 RS03570
gene id: 608506:COB47_RS03570
uniprot id: D9TJ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

608506:COB47 RS05390
gene id: 608506:COB47_RS05390
uniprot id: D9TK33
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04715
gene id: 608506:COB47_RS04715
uniprot id: D9TJR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

608506:COB47 RS09385
gene id: 608506:COB47_RS09385
uniprot id: D9TG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS10960
gene id: 608506:COB47_RS10960
uniprot id: D9TH31
names: Function
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.
messages: Belongs to the cellobiose 2-epimerase family.
messages: Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).

608506:COB47 RS07220
gene id: 608506:COB47_RS07220
uniprot id: D9TL43
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

608506:COB47 RS11465
gene id: 608506:COB47_RS11465
uniprot id: D9THN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

608506:COB47 RS05055
gene id: 608506:COB47_RS05055
uniprot id: D9TJX6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS02265
gene id: 608506:COB47_RS02265
uniprot id: D9TIF3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

608506:COB47 RS01555
gene id: 608506:COB47_RS01555
uniprot id: D9TI31
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608506:COB47 RS04045
gene id: 608506:COB47_RS04045
uniprot id: D9TJE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

608506:COB47 RS06665
gene id: 608506:COB47_RS06665
uniprot id: D9TKT2
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

608506:COB47 RS03380
gene id: 608506:COB47_RS03380
uniprot id: D9TJ17
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

608506:COB47 RS03940
gene id: 608506:COB47_RS03940
uniprot id: D9TJC3
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

608506:COB47 RS08170
gene id: 608506:COB47_RS08170
uniprot id: D9TFE0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS08130
gene id: 608506:COB47_RS08130
uniprot id: D9TFD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

608506:COB47 RS05805
gene id: 608506:COB47_RS05805
uniprot id: D9TKB7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

608506:COB47 RS04790
gene id: 608506:COB47_RS04790
uniprot id: D9TJS6
names: Similarity
messages: Belongs to the EamA transporter family.

608506:COB47 RS01680
gene id: 608506:COB47_RS01680
uniprot id: D9TI55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

608506:COB47 RS08875
gene id: 608506:COB47_RS08875
uniprot id: D9TFS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

608506:COB47 RS06920
gene id: 608506:COB47_RS06920
uniprot id: D9TKY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

608506:COB47 RS11105
gene id: 608506:COB47_RS11105
uniprot id: D9TH51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

608506:COB47 RS09380
gene id: 608506:COB47_RS09380
uniprot id: D9TG18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS03800
gene id: 608506:COB47_RS03800
uniprot id: D9TJ95
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

608506:COB47 RS06995
gene id: 608506:COB47_RS06995
uniprot id: D9TKZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

608506:COB47 RS08225
gene id: 608506:COB47_RS08225
uniprot id: D9TFF1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS04805
gene id: 608506:COB47_RS04805
uniprot id: D9TJS9
names: Similarity
messages: Belongs to the thioredoxin family.

608506:COB47 RS07800
gene id: 608506:COB47_RS07800
uniprot id: D9TLF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS07790
gene id: 608506:COB47_RS07790
uniprot id: D9TLF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608506:COB47 RS09680
gene id: 608506:COB47_RS09680
uniprot id: D9TG81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

608506:COB47 RS11560
gene id: 608506:COB47_RS11560
uniprot id: D9THQ2
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

608506:COB47 RS02965
gene id: 608506:COB47_RS02965
uniprot id: D9TIT7
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

608506:COB47 RS10545
gene id: 608506:COB47_RS10545
uniprot id: D9TGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07135
gene id: 608506:COB47_RS07135
uniprot id: D9TL26
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

608506:COB47 RS01740
gene id: 608506:COB47_RS01740
uniprot id: D9TI62
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

608506:COB47 RS08180
gene id: 608506:COB47_RS08180
uniprot id: D9TFE2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

608506:COB47 RS05175
gene id: 608506:COB47_RS05175
uniprot id: D9TJZ8
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS10950
gene id: 608506:COB47_RS10950
uniprot id: D9TH29
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

608506:COB47 RS09030
gene id: 608506:COB47_RS09030
uniprot id: D9TFV3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

608506:COB47 RS03030
gene id: 608506:COB47_RS03030
uniprot id: D9TIV0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

608506:COB47 RS00330
gene id: 608506:COB47_RS00330
uniprot id: D9TGV6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS06105
gene id: 608506:COB47_RS06105
uniprot id: D9TKG9
names: Subcellular Location Annotation
messages: Cytoplasm

608506:COB47 RS07225
gene id: 608506:COB47_RS07225
uniprot id: D9TL44
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

608506:COB47 RS00795
gene id: 608506:COB47_RS00795
uniprot id: D9THG0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS00840
gene id: 608506:COB47_RS00840
uniprot id: D9THG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05475
gene id: 608506:COB47_RS05475
uniprot id: D9TK51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

608506:COB47 RS02290
gene id: 608506:COB47_RS02290
uniprot id: D9TIF8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

608506:COB47 RS09065
gene id: 608506:COB47_RS09065
uniprot id: D9TFW0
names: Similarity
messages: Belongs to the glutamate synthase family.

608506:COB47 RS04830
gene id: 608506:COB47_RS04830
uniprot id: D9TJT5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

608506:COB47 RS03765
gene id: 608506:COB47_RS03765
uniprot id: D9TJ88
names: Similarity
messages: Belongs to the AOR/FOR family.

608506:COB47 RS11115
gene id: 608506:COB47_RS11115
uniprot id: D9TH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

608506:COB47 RS02705
gene id: 608506:COB47_RS02705
uniprot id: D9TIN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS03420
gene id: 608506:COB47_RS03420
uniprot id: D9TJ20
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

608506:COB47 RS06330
gene id: 608506:COB47_RS06330
uniprot id: D9TKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

608506:COB47 RS06500
gene id: 608506:COB47_RS06500
uniprot id: D9TKP9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

608506:COB47 RS03490
gene id: 608506:COB47_RS03490
uniprot id: D9TJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05370
gene id: 608506:COB47_RS05370
uniprot id: D9TK30
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

608506:COB47 RS08145
gene id: 608506:COB47_RS08145
uniprot id: D9TFD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

608506:COB47 RS05035
gene id: 608506:COB47_RS05035
uniprot id: D9TJX2
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

608506:COB47 RS11235
gene id: 608506:COB47_RS11235
uniprot id: D9TH76
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05540
gene id: 608506:COB47_RS05540
uniprot id: D9TK64
names: Similarity
messages: Belongs to the HypE family.

608506:COB47 RS09240
gene id: 608506:COB47_RS09240
uniprot id: D9TFZ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

608506:COB47 RS06805
gene id: 608506:COB47_RS06805
uniprot id: D9TKW0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

608506:COB47 RS06150
gene id: 608506:COB47_RS06150
uniprot id: D9TKH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

608506:COB47 RS09740
gene id: 608506:COB47_RS09740
uniprot id: D9TG92
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

608506:COB47 RS03815
gene id: 608506:COB47_RS03815
uniprot id: D9TJ98
names: Function
messages: May be involved in the biosynthesis of molybdopterin.

608506:COB47 RS05425
gene id: 608506:COB47_RS05425
uniprot id: D9TK41
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

608506:COB47 RS09495
gene id: 608506:COB47_RS09495
uniprot id: D9TG44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS03520
gene id: 608506:COB47_RS03520
uniprot id: D9TJ40
names: Similarity
messages: Belongs to the UPF0749 family.

608506:COB47 RS08645
gene id: 608506:COB47_RS08645
uniprot id: D9TFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS03930
gene id: 608506:COB47_RS03930
uniprot id: D9TJC1
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

608506:COB47 RS03115
gene id: 608506:COB47_RS03115
uniprot id: D9TIW7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

608506:COB47 RS03100
gene id: 608506:COB47_RS03100
uniprot id: D9TIW4
names: Similarity
messages: Belongs to the UPF0047 family.

608506:COB47 RS06730
gene id: 608506:COB47_RS06730
uniprot id: D9TKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

608506:COB47 RS06810
gene id: 608506:COB47_RS06810
uniprot id: D9TKW1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

608506:COB47 RS00205
gene id: 608506:COB47_RS00205
uniprot id: D9TGT5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS01685
gene id: 608506:COB47_RS01685
uniprot id: D9TI56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

608506:COB47 RS02760
gene id: 608506:COB47_RS02760
uniprot id: D9TIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS08185
gene id: 608506:COB47_RS08185
uniprot id: D9TFE3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

608506:COB47 RS02240
gene id: 608506:COB47_RS02240
uniprot id: D9TIE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

608506:COB47 RS09050
gene id: 608506:COB47_RS09050
uniprot id: D9TFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS09920
gene id: 608506:COB47_RS09920
uniprot id: D9TGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

608506:COB47 RS01145
gene id: 608506:COB47_RS01145
uniprot id: D9THV6
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS01890
gene id: 608506:COB47_RS01890
uniprot id: D9TI91
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

608506:COB47 RS04920
gene id: 608506:COB47_RS04920
uniprot id: D9TJV0
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05405
gene id: 608506:COB47_RS05405
uniprot id: D9TK37
names: Similarity
messages: Belongs to the UPF0111 family.

608506:COB47 RS06180
gene id: 608506:COB47_RS06180
uniprot id: D9TKI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS04215
gene id: 608506:COB47_RS04215
uniprot id: D9TJH4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

608506:COB47 RS07975
gene id: 608506:COB47_RS07975
uniprot id: D9TFA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

608506:COB47 RS10505
gene id: 608506:COB47_RS10505
uniprot id: D9TGM7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS05295
gene id: 608506:COB47_RS05295
uniprot id: D9TK15
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

608506:COB47 RS09075
gene id: 608506:COB47_RS09075
uniprot id: D9TFW2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS05580
gene id: 608506:COB47_RS05580
uniprot id: D9TK72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

608506:COB47 RS02085
gene id: 608506:COB47_RS02085
uniprot id: D9TIC5
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS05030
gene id: 608506:COB47_RS05030
uniprot id: D9TJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

608506:COB47 RS01290
gene id: 608506:COB47_RS01290
uniprot id: D9THY3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

608506:COB47 RS04270
gene id: 608506:COB47_RS04270
uniprot id: D9TJI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

608506:COB47 RS00065
gene id: 608506:COB47_RS00065
uniprot id: D9TGQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

608506:COB47 RS06170
gene id: 608506:COB47_RS06170
uniprot id: D9TKI2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

608506:COB47 RS01165
gene id: 608506:COB47_RS01165
uniprot id: D9THW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

608506:COB47 RS02865
gene id: 608506:COB47_RS02865
uniprot id: D9TIR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

608506:COB47 RS08055
gene id: 608506:COB47_RS08055
uniprot id: D9TFB7
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

608506:COB47 RS06015
gene id: 608506:COB47_RS06015
uniprot id: D9TKF4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

608506:COB47 RS11200
gene id: 608506:COB47_RS11200
uniprot id: D9TH69
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608506:COB47 RS08490
gene id: 608506:COB47_RS08490
uniprot id: D9TFK2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS06305
gene id: 608506:COB47_RS06305
uniprot id: D9TKL1
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

608506:COB47 RS00445
gene id: 608506:COB47_RS00445
uniprot id: D9TH97
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

608506:COB47 RS11430
gene id: 608506:COB47_RS11430
uniprot id: D9THN1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

608506:COB47 RS03320
gene id: 608506:COB47_RS03320
uniprot id: D9TJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

608506:COB47 RS03685
gene id: 608506:COB47_RS03685
uniprot id: D9TJ73
names: Similarity
messages: Belongs to the IMPACT family.

608506:COB47 RS09205
gene id: 608506:COB47_RS09205
uniprot id: D9TFY8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

608506:COB47 RS03205
gene id: 608506:COB47_RS03205
uniprot id: D9TIY4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

608506:COB47 RS06560
gene id: 608506:COB47_RS06560
uniprot id: D9TKR1
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

608506:COB47 RS00245
gene id: 608506:COB47_RS00245
uniprot id: D9TGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS02470
gene id: 608506:COB47_RS02470
uniprot id: D9TIJ2
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

608506:COB47 RS09390
gene id: 608506:COB47_RS09390
uniprot id: D9TG20
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS11555
gene id: 608506:COB47_RS11555
uniprot id: D9THQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

608506:COB47 RS06685
gene id: 608506:COB47_RS06685
uniprot id: D9TKT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS06470
gene id: 608506:COB47_RS06470
uniprot id: D9TKP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

608506:COB47 RS07770
gene id: 608506:COB47_RS07770
uniprot id: D9TLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

608506:COB47 RS02225
gene id: 608506:COB47_RS02225
uniprot id: D9TIE4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

608506:COB47 RS05145
gene id: 608506:COB47_RS05145
uniprot id: D9TJZ2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

608506:COB47 RS09950
gene id: 608506:COB47_RS09950
uniprot id: D9TGC9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

608506:COB47 RS08265
gene id: 608506:COB47_RS08265
uniprot id: D9TFF9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07400
gene id: 608506:COB47_RS07400
uniprot id: D9TL78
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

608506:COB47 RS08610
gene id: 608506:COB47_RS08610
uniprot id: D9TFM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

608506:COB47 RS07375
gene id: 608506:COB47_RS07375
uniprot id: D9TL73
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

608506:COB47 RS04200
gene id: 608506:COB47_RS04200
uniprot id: D9TJH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

608506:COB47 RS04245
gene id: 608506:COB47_RS04245
uniprot id: D9TJI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

608506:COB47 RS01940
gene id: 608506:COB47_RS01940
uniprot id: D9TIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

608506:COB47 RS12230
gene id: 608506:COB47_RS12230
uniprot id: D9TI74
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

608506:COB47 RS03195
gene id: 608506:COB47_RS03195
uniprot id: D9TIY1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

608506:COB47 RS00375
gene id: 608506:COB47_RS00375
uniprot id: D9TGW5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04465
gene id: 608506:COB47_RS04465
uniprot id: D9TJL8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS08120
gene id: 608506:COB47_RS08120
uniprot id: D9TFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

608506:COB47 RS08780
gene id: 608506:COB47_RS08780
uniprot id: D9TFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS04180
gene id: 608506:COB47_RS04180
uniprot id: D9TJG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

608506:COB47 RS10715
gene id: 608506:COB47_RS10715
uniprot id: D9TGY9
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07130
gene id: 608506:COB47_RS07130
uniprot id: D9TL25
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

608506:COB47 RS01365
gene id: 608506:COB47_RS01365
uniprot id: D9THZ8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

608506:COB47 RS05415
gene id: 608506:COB47_RS05415
uniprot id: D9TK39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

608506:COB47 RS03210
gene id: 608506:COB47_RS03210
uniprot id: D9TIY5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

608506:COB47 RS05140
gene id: 608506:COB47_RS05140
uniprot id: D9TJZ1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

608506:COB47 RS08530
gene id: 608506:COB47_RS08530
uniprot id: D9TFK9
names: Similarity
messages: Belongs to the peptidase C40 family.

608506:COB47 RS03470
gene id: 608506:COB47_RS03470
uniprot id: D9TJ30
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS00265
gene id: 608506:COB47_RS00265
uniprot id: D9TGU4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

608506:COB47 RS02750
gene id: 608506:COB47_RS02750
uniprot id: D9TIP3
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS04880
gene id: 608506:COB47_RS04880
uniprot id: D9TJU4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

608506:COB47 RS03545
gene id: 608506:COB47_RS03545
uniprot id: D9TJ45
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

608506:COB47 RS06195
gene id: 608506:COB47_RS06195
uniprot id: D9TKI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

608506:COB47 RS01560
gene id: 608506:COB47_RS01560
uniprot id: D9TI32
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

608506:COB47 RS04310
gene id: 608506:COB47_RS04310
uniprot id: D9TJJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

608506:COB47 RS07700
gene id: 608506:COB47_RS07700
uniprot id: D9TLD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

608506:COB47 RS08615
gene id: 608506:COB47_RS08615
uniprot id: D9TFM7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

608506:COB47 RS07725
gene id: 608506:COB47_RS07725
uniprot id: D9TLE2
names: Similarity
messages: Belongs to the UPF0102 family.

608506:COB47 RS05400
gene id: 608506:COB47_RS05400
uniprot id: D9TK36
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS02520
gene id: 608506:COB47_RS02520
uniprot id: D9TIK2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

608506:COB47 RS05620
gene id: 608506:COB47_RS05620
uniprot id: D9TK80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

608506:COB47 RS08735
gene id: 608506:COB47_RS08735
uniprot id: D9TFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS10310
gene id: 608506:COB47_RS10310
uniprot id: D9TGJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

608506:COB47 RS03410
gene id: 608506:COB47_RS03410
uniprot id: D9TJ18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

608506:COB47 RS04975
gene id: 608506:COB47_RS04975
uniprot id: D9TJW1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

608506:COB47 RS05445
gene id: 608506:COB47_RS05445
uniprot id: D9TK45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

608506:COB47 RS03375
gene id: 608506:COB47_RS03375
uniprot id: D9TJ16
names: Subcellular Location Annotation
messages: Cytoplasm

608506:COB47 RS09560
gene id: 608506:COB47_RS09560
uniprot id: D9TG57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

608506:COB47 RS06120
gene id: 608506:COB47_RS06120
uniprot id: D9TKH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

608506:COB47 RS00505
gene id: 608506:COB47_RS00505
uniprot id: D9THA7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS06615
gene id: 608506:COB47_RS06615
uniprot id: D9TKS2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

608506:COB47 RS02745
gene id: 608506:COB47_RS02745
uniprot id: D9TIP2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS04985
gene id: 608506:COB47_RS04985
uniprot id: D9TJW3
names: Similarity
messages: Belongs to the SleB family.

608506:COB47 RS11650
gene id: 608506:COB47_RS11650
uniprot id: D9THS1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

608506:COB47 RS09640
gene id: 608506:COB47_RS09640
uniprot id: D9TG73
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

608506:COB47 RS10390
gene id: 608506:COB47_RS10390
uniprot id: D9TGL0
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

608506:COB47 RS05935
gene id: 608506:COB47_RS05935
uniprot id: D9TKE2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00025
gene id: 608506:COB47_RS00025
uniprot id: D9TGP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

608506:COB47 RS02905
gene id: 608506:COB47_RS02905
uniprot id: D9TIS5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

608506:COB47 RS07295
gene id: 608506:COB47_RS07295
uniprot id: D9TL58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

608506:COB47 RS03485
gene id: 608506:COB47_RS03485
uniprot id: D9TJ33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

608506:COB47 RS09975
gene id: 608506:COB47_RS09975
uniprot id: D9TGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS10735
gene id: 608506:COB47_RS10735
uniprot id: D9TGZ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

608506:COB47 RS02875
gene id: 608506:COB47_RS02875
uniprot id: D9TIR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

608506:COB47 RS10810
gene id: 608506:COB47_RS10810
uniprot id: D9TH05
names: Similarity
messages: Belongs to the FGGY kinase family.

608506:COB47 RS05920
gene id: 608506:COB47_RS05920
uniprot id: D9TKD9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

608506:COB47 RS08660
gene id: 608506:COB47_RS08660
uniprot id: D9TFN6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

608506:COB47 RS10520
gene id: 608506:COB47_RS10520
uniprot id: D9TGN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

608506:COB47 RS08050
gene id: 608506:COB47_RS08050
uniprot id: D9TFB6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

608506:COB47 RS09455
gene id: 608506:COB47_RS09455
uniprot id: D9TG33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

608506:COB47 RS05680
gene id: 608506:COB47_RS05680
uniprot id: D9TK92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608506:COB47 RS03240
gene id: 608506:COB47_RS03240
uniprot id: D9TIZ1
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

608506:COB47 RS02405
gene id: 608506:COB47_RS02405
uniprot id: D9TII0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00590
gene id: 608506:COB47_RS00590
uniprot id: D9THC4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

608506:COB47 RS06530
gene id: 608506:COB47_RS06530
uniprot id: D9TKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

608506:COB47 RS09800
gene id: 608506:COB47_RS09800
uniprot id: D9TGA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

608506:COB47 RS06740
gene id: 608506:COB47_RS06740
uniprot id: D9TKU7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS09150
gene id: 608506:COB47_RS09150
uniprot id: D9TFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

608506:COB47 RS05660
gene id: 608506:COB47_RS05660
uniprot id: D9TK88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS07320
gene id: 608506:COB47_RS07320
uniprot id: D9TL63
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

608506:COB47 RS10165
gene id: 608506:COB47_RS10165
uniprot id: D9TGG8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS09345
gene id: 608506:COB47_RS09345
uniprot id: D9TG14
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

608506:COB47 RS04680
gene id: 608506:COB47_RS04680
uniprot id: D9TJQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

608506:COB47 RS06545
gene id: 608506:COB47_RS06545
uniprot id: D9TKQ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

608506:COB47 RS09825
gene id: 608506:COB47_RS09825
uniprot id: D9TGA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

608506:COB47 RS10590
gene id: 608506:COB47_RS10590
uniprot id: D9TGP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS01915
gene id: 608506:COB47_RS01915
uniprot id: D9TI96
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

608506:COB47 RS07960
gene id: 608506:COB47_RS07960
uniprot id: D9TF98
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

608506:COB47 RS05705
gene id: 608506:COB47_RS05705
uniprot id: D9TK97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

608506:COB47 RS08485
gene id: 608506:COB47_RS08485
uniprot id: D9TFK1
names: Similarity
messages: Belongs to the GSP E family.

608506:COB47 RS10940
gene id: 608506:COB47_RS10940
uniprot id: D9TH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05260
gene id: 608506:COB47_RS05260
uniprot id: D9TK09
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS04150
gene id: 608506:COB47_RS04150
uniprot id: D9TJG0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS11270
gene id: 608506:COB47_RS11270
uniprot id: D9TH81
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

608506:COB47 RS04555
gene id: 608506:COB47_RS04555
uniprot id: D9TJN4
names: Similarity
messages: Belongs to the FlgM family.

608506:COB47 RS01275
gene id: 608506:COB47_RS01275
uniprot id: D9THY0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

608506:COB47 RS05360
gene id: 608506:COB47_RS05360
uniprot id: D9TK28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

608506:COB47 RS05690
gene id: 608506:COB47_RS05690
uniprot id: D9TK94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

608506:COB47 RS06290
gene id: 608506:COB47_RS06290
uniprot id: D9TKK8
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS09135
gene id: 608506:COB47_RS09135
uniprot id: D9TFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS08015
gene id: 608506:COB47_RS08015
uniprot id: D9TFA9
names: Similarity
messages: Belongs to the BMP lipoprotein family.

608506:COB47 RS08810
gene id: 608506:COB47_RS08810
uniprot id: D9TFR4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608506:COB47 RS07260
gene id: 608506:COB47_RS07260
uniprot id: D9TL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

608506:COB47 RS08165
gene id: 608506:COB47_RS08165
uniprot id: D9TFD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

608506:COB47 RS06990
gene id: 608506:COB47_RS06990
uniprot id: D9TKZ6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

608506:COB47 RS05625
gene id: 608506:COB47_RS05625
uniprot id: D9TK81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

608506:COB47 RS09720
gene id: 608506:COB47_RS09720
uniprot id: D9TG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

608506:COB47 RS04425
gene id: 608506:COB47_RS04425
uniprot id: D9TJL0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

608506:COB47 RS08585
gene id: 608506:COB47_RS08585
uniprot id: D9TFM0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

608506:COB47 RS08825
gene id: 608506:COB47_RS08825
uniprot id: D9TFR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

608506:COB47 RS10550
gene id: 608506:COB47_RS10550
uniprot id: D9TGN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS05600
gene id: 608506:COB47_RS05600
uniprot id: D9TK76
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

608506:COB47 RS11600
gene id: 608506:COB47_RS11600
uniprot id: D9THR1
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

608506:COB47 RS02485
gene id: 608506:COB47_RS02485
uniprot id: D9TIJ5
names: Similarity
messages: Belongs to the UPF0758 family.

608506:COB47 RS03315
gene id: 608506:COB47_RS03315
uniprot id: D9TJ05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

608506:COB47 RS03625
gene id: 608506:COB47_RS03625
uniprot id: D9TJ61
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS00045
gene id: 608506:COB47_RS00045
uniprot id: D9TGQ4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

608506:COB47 RS06155
gene id: 608506:COB47_RS06155
uniprot id: D9TKH9
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS09230
gene id: 608506:COB47_RS09230
uniprot id: D9TFZ4
names: Similarity
messages: Belongs to the P(II) protein family.

608506:COB47 RS00420
gene id: 608506:COB47_RS00420
uniprot id: D9TH94
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

608506:COB47 RS02245
gene id: 608506:COB47_RS02245
uniprot id: D9TIE9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

608506:COB47 RS08345
gene id: 608506:COB47_RS08345
uniprot id: D9TFH3
names: Similarity
messages: Belongs to the polysaccharide lyase 3 family.

608506:COB47 RS08100
gene id: 608506:COB47_RS08100
uniprot id: D9TFC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

608506:COB47 RS04735
gene id: 608506:COB47_RS04735
uniprot id: D9TJR6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

608506:COB47 RS03255
gene id: 608506:COB47_RS03255
uniprot id: D9TIZ4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

608506:COB47 RS09045
gene id: 608506:COB47_RS09045
uniprot id: D9TFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS09210
gene id: 608506:COB47_RS09210
uniprot id: D9TFY9
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

608506:COB47 RS07035
gene id: 608506:COB47_RS07035
uniprot id: D9TL06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

608506:COB47 RS10125
gene id: 608506:COB47_RS10125
uniprot id: D9TGF9
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS06295
gene id: 608506:COB47_RS06295
uniprot id: D9TKK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

608506:COB47 RS07695
gene id: 608506:COB47_RS07695
uniprot id: D9TLD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

608506:COB47 RS04585
gene id: 608506:COB47_RS04585
uniprot id: D9TJP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

608506:COB47 RS02855
gene id: 608506:COB47_RS02855
uniprot id: D9TIR5
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

608506:COB47 RS02940
gene id: 608506:COB47_RS02940
uniprot id: D9TIT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

608506:COB47 RS04250
gene id: 608506:COB47_RS04250
uniprot id: D9TJI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

608506:COB47 RS03465
gene id: 608506:COB47_RS03465
uniprot id: D9TJ29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

608506:COB47 RS06570
gene id: 608506:COB47_RS06570
uniprot id: D9TKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

608506:COB47 RS00005
gene id: 608506:COB47_RS00005
uniprot id: D9TGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

608506:COB47 RS11110
gene id: 608506:COB47_RS11110
uniprot id: D9TH52
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

608506:COB47 RS06145
gene id: 608506:COB47_RS06145
uniprot id: D9TKH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

608506:COB47 RS09780
gene id: 608506:COB47_RS09780
uniprot id: D9TGA0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

608506:COB47 RS05650
gene id: 608506:COB47_RS05650
uniprot id: D9TK86
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

608506:COB47 RS03795
gene id: 608506:COB47_RS03795
uniprot id: D9TJ94
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

608506:COB47 RS07410
gene id: 608506:COB47_RS07410
uniprot id: D9TL80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

608506:COB47 RS11125
gene id: 608506:COB47_RS11125
uniprot id: D9TH55
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS00465
gene id: 608506:COB47_RS00465
uniprot id: D9THA0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS11005
gene id: 608506:COB47_RS11005
uniprot id: D9TH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

608506:COB47 RS02695
gene id: 608506:COB47_RS02695
uniprot id: D9TIN2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

608506:COB47 RS01985
gene id: 608506:COB47_RS01985
uniprot id: D9TIA8
names: Similarity
messages: Belongs to the hemerythrin family.

608506:COB47 RS06160
gene id: 608506:COB47_RS06160
uniprot id: D9TKI0
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

608506:COB47 RS08630
gene id: 608506:COB47_RS08630
uniprot id: D9TFN0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

608506:COB47 RS05050
gene id: 608506:COB47_RS05050
uniprot id: D9TJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

608506:COB47 RS05150
gene id: 608506:COB47_RS05150
uniprot id: D9TJZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

608506:COB47 RS06885
gene id: 608506:COB47_RS06885
uniprot id: D9TKX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

608506:COB47 RS11710
gene id: 608506:COB47_RS11710
uniprot id: D9THT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

608506:COB47 RS05700
gene id: 608506:COB47_RS05700
uniprot id: D9TK96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

608506:COB47 RS02815
gene id: 608506:COB47_RS02815
uniprot id: D9TIQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS06930
gene id: 608506:COB47_RS06930
uniprot id: D9TKY3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

608506:COB47 RS03095
gene id: 608506:COB47_RS03095
uniprot id: D9TIW3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

608506:COB47 RS10895
gene id: 608506:COB47_RS10895
uniprot id: D9TH19
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

608506:COB47 RS10425
gene id: 608506:COB47_RS10425
uniprot id: D9TGL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608506:COB47 RS11665
gene id: 608506:COB47_RS11665
uniprot id: D9THS4
names: Subcellular Location Annotation
messages: Membrane

608506:COB47 RS07795
gene id: 608506:COB47_RS07795
uniprot id: D9TLF6
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

608506:COB47 RS01445
gene id: 608506:COB47_RS01445
uniprot id: D9TI13
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

608506:COB47 RS02890
gene id: 608506:COB47_RS02890
uniprot id: D9TIS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608506:COB47 RS09820
gene id: 608506:COB47_RS09820
uniprot id: D9TGA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

608506:COB47 RS04970
gene id: 608506:COB47_RS04970
uniprot id: D9TJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

608506:COB47 RS11015
gene id: 608506:COB47_RS11015
uniprot id: D9TH38
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

608506:COB47 RS06715
gene id: 608506:COB47_RS06715
uniprot id: D9TKU2
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

608506:COB47 RS02025
gene id: 608506:COB47_RS02025
uniprot id: D9TIB4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

608506:COB47 RS09880
gene id: 608506:COB47_RS09880
uniprot id: D9TGB8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

608506:COB47 RS04225
gene id: 608506:COB47_RS04225
uniprot id: D9TJH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

608506:COB47 RS10260
gene id: 608506:COB47_RS10260
uniprot id: D9TGI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

608506:COB47 RS08235
gene id: 608506:COB47_RS08235
uniprot id: D9TFF3
names: Similarity
messages: Belongs to the CtsR family.

608506:COB47 RS05585
gene id: 608506:COB47_RS05585
uniprot id: D9TK73
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.