604354:TSIB RS03185
gene id: 604354:TSIB_RS03185
uniprot id: C6A265
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

604354:TSIB RS00510
gene id: 604354:TSIB_RS00510
uniprot id: C6A0M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

604354:TSIB RS09870
gene id: 604354:TSIB_RS09870
uniprot id: C6A098
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

604354:TSIB RS06505
gene id: 604354:TSIB_RS06505
uniprot id: C6A447
names: Similarity
messages: Belongs to the UPF0440 family.

604354:TSIB RS02290
gene id: 604354:TSIB_RS02290
uniprot id: C6A1M8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

604354:TSIB RS08535
gene id: 604354:TSIB_RS08535
uniprot id: C6A5B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS07360
gene id: 604354:TSIB_RS07360
uniprot id: C6A4M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

604354:TSIB RS01470
gene id: 604354:TSIB_RS01470
uniprot id: C6A173
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

604354:TSIB RS08210
gene id: 604354:TSIB_RS08210
uniprot id: C6A540
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

604354:TSIB RS08570
gene id: 604354:TSIB_RS08570
uniprot id: C6A5B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

604354:TSIB RS01920
gene id: 604354:TSIB_RS01920
uniprot id: C6A1F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

604354:TSIB RS00685
gene id: 604354:TSIB_RS00685
uniprot id: C6A0R0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

604354:TSIB RS02470
gene id: 604354:TSIB_RS02470
uniprot id: C6A1R8
names: Similarity
messages: Belongs to the peptidase S49 family.

604354:TSIB RS01405
gene id: 604354:TSIB_RS01405
uniprot id: C6A160
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

604354:TSIB RS04980
gene id: 604354:TSIB_RS04980
uniprot id: C6A385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

604354:TSIB RS03510
gene id: 604354:TSIB_RS03510
uniprot id: C6A2D2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

604354:TSIB RS05395
gene id: 604354:TSIB_RS05395
uniprot id: C6A3G6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

604354:TSIB RS09315
gene id: 604354:TSIB_RS09315
uniprot id: C5ZZY2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS08955
gene id: 604354:TSIB_RS08955
uniprot id: C6A5J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

604354:TSIB RS04815
gene id: 604354:TSIB_RS04815
uniprot id: C6A351
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

604354:TSIB RS05930
gene id: 604354:TSIB_RS05930
uniprot id: C6A3T1
names: Similarity
messages: Belongs to the MEMO1 family.

604354:TSIB RS05565
gene id: 604354:TSIB_RS05565
uniprot id: C6A3K3
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS04880
gene id: 604354:TSIB_RS04880
uniprot id: C6A366
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

604354:TSIB RS05005
gene id: 604354:TSIB_RS05005
uniprot id: C6A390
names: Similarity
messages: Belongs to the UPF0282 family.

604354:TSIB RS02620
gene id: 604354:TSIB_RS02620
uniprot id: C6A1U8
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

604354:TSIB RS05265
gene id: 604354:TSIB_RS05265
uniprot id: C6A3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

604354:TSIB RS07080
gene id: 604354:TSIB_RS07080
uniprot id: C6A4G4
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

604354:TSIB RS06520
gene id: 604354:TSIB_RS06520
uniprot id: C6A450
names: Function
messages: Probably involved in the biogenesis of the ribosome.

604354:TSIB RS01815
gene id: 604354:TSIB_RS01815
uniprot id: C6A1E1
names: Similarity
messages: Belongs to the BtpA family.

604354:TSIB RS03495
gene id: 604354:TSIB_RS03495
uniprot id: C6A2C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

604354:TSIB RS05445
gene id: 604354:TSIB_RS05445
uniprot id: C6A3H7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS02150
gene id: 604354:TSIB_RS02150
uniprot id: C6A1K1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

604354:TSIB RS02375
gene id: 604354:TSIB_RS02375
uniprot id: C6A1P7
names: Similarity
messages: Belongs to the AOR/FOR family.

604354:TSIB RS03535
gene id: 604354:TSIB_RS03535
uniprot id: C6A2D7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

604354:TSIB RS00400
gene id: 604354:TSIB_RS00400
uniprot id: C6A0K3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

604354:TSIB RS04595
gene id: 604354:TSIB_RS04595
uniprot id: C6A305
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS00630
gene id: 604354:TSIB_RS00630
uniprot id: C6A0P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

604354:TSIB RS01940
gene id: 604354:TSIB_RS01940
uniprot id: C6A1G2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

604354:TSIB RS07710
gene id: 604354:TSIB_RS07710
uniprot id: C6A4U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

604354:TSIB RS00870
gene id: 604354:TSIB_RS00870
uniprot id: C6A0V2
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02190
gene id: 604354:TSIB_RS02190
uniprot id: C6A1K9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

604354:TSIB RS03195
gene id: 604354:TSIB_RS03195
uniprot id: C6A267
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

604354:TSIB RS02510
gene id: 604354:TSIB_RS02510
uniprot id: C6A1S6
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

604354:TSIB RS02805
gene id: 604354:TSIB_RS02805
uniprot id: C6A1Y5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

604354:TSIB RS04305
gene id: 604354:TSIB_RS04305
uniprot id: C6A2U7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

604354:TSIB RS00255
gene id: 604354:TSIB_RS00255
uniprot id: C6A0H6
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01400
gene id: 604354:TSIB_RS01400
uniprot id: C6A159
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

604354:TSIB RS06730
gene id: 604354:TSIB_RS06730
uniprot id: C6A493
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS04885
gene id: 604354:TSIB_RS04885
uniprot id: C6A367
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

604354:TSIB RS09800
gene id: 604354:TSIB_RS09800
uniprot id: C6A084
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02340
gene id: 604354:TSIB_RS02340
uniprot id: C6A1N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

604354:TSIB RS03500
gene id: 604354:TSIB_RS03500
uniprot id: C6A2D0
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

604354:TSIB RS09090
gene id: 604354:TSIB_RS09090
uniprot id: C5ZZT6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

604354:TSIB RS07110
gene id: 604354:TSIB_RS07110
uniprot id: C6A4G9
names: Similarity
messages: Belongs to the UPF0127 family.

604354:TSIB RS06435
gene id: 604354:TSIB_RS06435
uniprot id: C6A433
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

604354:TSIB RS06095
gene id: 604354:TSIB_RS06095
uniprot id: C6A3W6
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

604354:TSIB RS04055
gene id: 604354:TSIB_RS04055
uniprot id: C6A2P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

604354:TSIB RS09500
gene id: 604354:TSIB_RS09500
uniprot id: C6A024
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07075
gene id: 604354:TSIB_RS07075
uniprot id: C6A4G3
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

604354:TSIB RS05575
gene id: 604354:TSIB_RS05575
uniprot id: C6A3K6
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01455
gene id: 604354:TSIB_RS01455
uniprot id: C6A170
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

604354:TSIB RS01515
gene id: 604354:TSIB_RS01515
uniprot id: C6A182
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

604354:TSIB RS01770
gene id: 604354:TSIB_RS01770
uniprot id: C6A1D3
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

604354:TSIB RS04810
gene id: 604354:TSIB_RS04810
uniprot id: C6A350
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

604354:TSIB RS01530
gene id: 604354:TSIB_RS01530
uniprot id: C6A185
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS05880
gene id: 604354:TSIB_RS05880
uniprot id: C6A3S1
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06960
gene id: 604354:TSIB_RS06960
uniprot id: C6A4E0
names: Similarity
messages: Belongs to the HypD family.

604354:TSIB RS00135
gene id: 604354:TSIB_RS00135
uniprot id: C6A0F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

604354:TSIB RS03595
gene id: 604354:TSIB_RS03595
uniprot id: C6A2E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

604354:TSIB RS03415
gene id: 604354:TSIB_RS03415
uniprot id: C6A2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

604354:TSIB RS01945
gene id: 604354:TSIB_RS01945
uniprot id: C6A1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

604354:TSIB RS05455
gene id: 604354:TSIB_RS05455
uniprot id: C6A3I0
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

604354:TSIB RS02210
gene id: 604354:TSIB_RS02210
uniprot id: C6A1L3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

604354:TSIB RS01295
gene id: 604354:TSIB_RS01295
uniprot id: C6A139
names: Similarity
messages: Belongs to the peptidase S8 family.

604354:TSIB RS00505
gene id: 604354:TSIB_RS00505
uniprot id: C6A0M4
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

604354:TSIB RS03480
gene id: 604354:TSIB_RS03480
uniprot id: C6A2C6
names: Subcellular Location Annotation
messages: Nucleus

604354:TSIB RS02410
gene id: 604354:TSIB_RS02410
uniprot id: C6A1Q5
names: Similarity
messages: Belongs to the UPF0166 family.

604354:TSIB RS03260
gene id: 604354:TSIB_RS03260
uniprot id: C6A281
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

604354:TSIB RS09325
gene id: 604354:TSIB_RS09325
uniprot id: C5ZZY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS01450
gene id: 604354:TSIB_RS01450
uniprot id: C6A169
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS01885
gene id: 604354:TSIB_RS01885
uniprot id: C6A1F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

604354:TSIB RS06440
gene id: 604354:TSIB_RS06440
uniprot id: C6A434
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

604354:TSIB RS01535
gene id: 604354:TSIB_RS01535
uniprot id: C6A186
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

604354:TSIB RS05780
gene id: 604354:TSIB_RS05780
uniprot id: C6A3Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

604354:TSIB RS05920
gene id: 604354:TSIB_RS05920
uniprot id: C6A3S9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

604354:TSIB RS07430
gene id: 604354:TSIB_RS07430
uniprot id: C6A4N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

604354:TSIB RS06775
gene id: 604354:TSIB_RS06775
uniprot id: C6A4A3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

604354:TSIB RS02725
gene id: 604354:TSIB_RS02725
uniprot id: C6A1W8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

604354:TSIB RS08745
gene id: 604354:TSIB_RS08745
uniprot id: C6A5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

604354:TSIB RS06270
gene id: 604354:TSIB_RS06270
uniprot id: C6A401
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS01375
gene id: 604354:TSIB_RS01375
uniprot id: C6A154
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

604354:TSIB RS08495
gene id: 604354:TSIB_RS08495
uniprot id: C6A5A0
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS05260
gene id: 604354:TSIB_RS05260
uniprot id: C6A3E0
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01660
gene id: 604354:TSIB_RS01660
uniprot id: C6A1B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS09180
gene id: 604354:TSIB_RS09180
uniprot id: C5ZZV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS03210
gene id: 604354:TSIB_RS03210
uniprot id: C6A270
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

604354:TSIB RS02590
gene id: 604354:TSIB_RS02590
uniprot id: C6A1U2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

604354:TSIB RS04100
gene id: 604354:TSIB_RS04100
uniprot id: C6A2Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS04995
gene id: 604354:TSIB_RS04995
uniprot id: C6A388
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

604354:TSIB RS08505
gene id: 604354:TSIB_RS08505
uniprot id: C6A5A3
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

604354:TSIB RS09260
gene id: 604354:TSIB_RS09260
uniprot id: C5ZZX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

604354:TSIB RS03800
gene id: 604354:TSIB_RS03800
uniprot id: C6A2J1
names: Similarity
messages: Belongs to the NodU/CmcH family.

604354:TSIB RS09610
gene id: 604354:TSIB_RS09610
uniprot id: C6A048
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

604354:TSIB RS02990
gene id: 604354:TSIB_RS02990
uniprot id: C6A224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

604354:TSIB RS09915
gene id: 604354:TSIB_RS09915
uniprot id: C6A0A7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

604354:TSIB RS03000
gene id: 604354:TSIB_RS03000
uniprot id: C6A226
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

604354:TSIB RS04240
gene id: 604354:TSIB_RS04240
uniprot id: C6A2T5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

604354:TSIB RS05940
gene id: 604354:TSIB_RS05940
uniprot id: C6A3T4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

604354:TSIB RS00330
gene id: 604354:TSIB_RS00330
uniprot id: C6A0I9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

604354:TSIB RS08215
gene id: 604354:TSIB_RS08215
uniprot id: C6A541
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

604354:TSIB RS06285
gene id: 604354:TSIB_RS06285
uniprot id: C6A404
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS01070
gene id: 604354:TSIB_RS01070
uniprot id: C6A0Z2
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02495
gene id: 604354:TSIB_RS02495
uniprot id: C6A1S3
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08225
gene id: 604354:TSIB_RS08225
uniprot id: C6A543
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

604354:TSIB RS06240
gene id: 604354:TSIB_RS06240
uniprot id: C6A3Z5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

604354:TSIB RS05075
gene id: 604354:TSIB_RS05075
uniprot id: C6A3A2
names: Similarity
messages: Belongs to the DEAD box helicase family.

604354:TSIB RS05380
gene id: 604354:TSIB_RS05380
uniprot id: C6A3G3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

604354:TSIB RS05895
gene id: 604354:TSIB_RS05895
uniprot id: C6A3S4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

604354:TSIB RS04430
gene id: 604354:TSIB_RS04430
uniprot id: C6A2X0
names: Subunit
messages: Homotetramer.

604354:TSIB RS09940
gene id: 604354:TSIB_RS09940
uniprot id: C6A0B2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

604354:TSIB RS05970
gene id: 604354:TSIB_RS05970
uniprot id: C6A3U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS05990
gene id: 604354:TSIB_RS05990
uniprot id: C6A3U4
names: Similarity
messages: Belongs to the DSD1 family.

604354:TSIB RS02455
gene id: 604354:TSIB_RS02455
uniprot id: C6A1R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

604354:TSIB RS06460
gene id: 604354:TSIB_RS06460
uniprot id: C6A438
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS04300
gene id: 604354:TSIB_RS04300
uniprot id: C6A2U6
names: Similarity
messages: Belongs to the DDAH family.

604354:TSIB RS02610
gene id: 604354:TSIB_RS02610
uniprot id: C6A1U6
names: Similarity
messages: Belongs to the PDCD5 family.

604354:TSIB RS08150
gene id: 604354:TSIB_RS08150
uniprot id: C6A529
names: Similarity
messages: Belongs to the thioesterase PaaI family.

604354:TSIB RS03365
gene id: 604354:TSIB_RS03365
uniprot id: C6A2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

604354:TSIB RS05505
gene id: 604354:TSIB_RS05505
uniprot id: C6A3J1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

604354:TSIB RS07600
gene id: 604354:TSIB_RS07600
uniprot id: C6A4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

604354:TSIB RS07795
gene id: 604354:TSIB_RS07795
uniprot id: C6A4V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

604354:TSIB RS08965
gene id: 604354:TSIB_RS08965
uniprot id: C6A5J8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

604354:TSIB RS09195
gene id: 604354:TSIB_RS09195
uniprot id: C5ZZV9
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS05650
gene id: 604354:TSIB_RS05650
uniprot id: C6A3M2
names: Similarity
messages: Belongs to the acylphosphatase family.

604354:TSIB RS04740
gene id: 604354:TSIB_RS04740
uniprot id: C6A335
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

604354:TSIB RS05255
gene id: 604354:TSIB_RS05255
uniprot id: C6A3D8
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08910
gene id: 604354:TSIB_RS08910
uniprot id: C6A5I7
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

604354:TSIB RS08600
gene id: 604354:TSIB_RS08600
uniprot id: C6A5C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

604354:TSIB RS02065
gene id: 604354:TSIB_RS02065
uniprot id: C6A1I4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

604354:TSIB RS08950
gene id: 604354:TSIB_RS08950
uniprot id: C6A5J5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

604354:TSIB RS06395
gene id: 604354:TSIB_RS06395
uniprot id: C6A424
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS00275
gene id: 604354:TSIB_RS00275
uniprot id: C6A0H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

604354:TSIB RS07730
gene id: 604354:TSIB_RS07730
uniprot id: C6A4U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

604354:TSIB RS04935
gene id: 604354:TSIB_RS04935
uniprot id: C6A376
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS09080
gene id: 604354:TSIB_RS09080
uniprot id: C5ZZT4
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02205
gene id: 604354:TSIB_RS02205
uniprot id: C6A1L2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS01480
gene id: 604354:TSIB_RS01480
uniprot id: C6A175
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS03140
gene id: 604354:TSIB_RS03140
uniprot id: C6A254
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS05385
gene id: 604354:TSIB_RS05385
uniprot id: C6A3G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

604354:TSIB RS01420
gene id: 604354:TSIB_RS01420
uniprot id: C6A163
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

604354:TSIB RS04145
gene id: 604354:TSIB_RS04145
uniprot id: C6A2R5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

604354:TSIB RS06370
gene id: 604354:TSIB_RS06370
uniprot id: C6A420
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

604354:TSIB RS04800
gene id: 604354:TSIB_RS04800
uniprot id: C6A348
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

604354:TSIB RS00875
gene id: 604354:TSIB_RS00875
uniprot id: C6A0V3
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01745
gene id: 604354:TSIB_RS01745
uniprot id: C6A1C8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

604354:TSIB RS01510
gene id: 604354:TSIB_RS01510
uniprot id: C6A181
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

604354:TSIB RS02515
gene id: 604354:TSIB_RS02515
uniprot id: C6A1S7
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS01525
gene id: 604354:TSIB_RS01525
uniprot id: C6A184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

604354:TSIB RS02625
gene id: 604354:TSIB_RS02625
uniprot id: C6A1U9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

604354:TSIB RS00130
gene id: 604354:TSIB_RS00130
uniprot id: C6A0F2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

604354:TSIB RS04155
gene id: 604354:TSIB_RS04155
uniprot id: C6A2R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

604354:TSIB RS09155
gene id: 604354:TSIB_RS09155
uniprot id: C5ZZU9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

604354:TSIB RS05985
gene id: 604354:TSIB_RS05985
uniprot id: C6A3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

604354:TSIB RS01020
gene id: 604354:TSIB_RS01020
uniprot id: C6A0Y2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

604354:TSIB RS03085
gene id: 604354:TSIB_RS03085
uniprot id: C6A243
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

604354:TSIB RS03290
gene id: 604354:TSIB_RS03290
uniprot id: C6A287
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

604354:TSIB RS01950
gene id: 604354:TSIB_RS01950
uniprot id: C6A1G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

604354:TSIB RS04290
gene id: 604354:TSIB_RS04290
uniprot id: C6A2U4
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08560
gene id: 604354:TSIB_RS08560
uniprot id: C6A5B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

604354:TSIB RS02800
gene id: 604354:TSIB_RS02800
uniprot id: C6A1Y3
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

604354:TSIB RS00790
gene id: 604354:TSIB_RS00790
uniprot id: C6A0T4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

604354:TSIB RS04015
gene id: 604354:TSIB_RS04015
uniprot id: C6A2N7
names: Similarity
messages: Belongs to the peptidase M24B family.

604354:TSIB RS08095
gene id: 604354:TSIB_RS08095
uniprot id: C6A517
names: Subunit
messages: Homodimer.

604354:TSIB RS05665
gene id: 604354:TSIB_RS05665
uniprot id: C6A3M6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

604354:TSIB RS07885
gene id: 604354:TSIB_RS07885
uniprot id: C6A4X5
names: Similarity
messages: Belongs to the AOR/FOR family.

604354:TSIB RS06190
gene id: 604354:TSIB_RS06190
uniprot id: C6A3Y7
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

604354:TSIB RS07735
gene id: 604354:TSIB_RS07735
uniprot id: C6A4U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

604354:TSIB RS06260
gene id: 604354:TSIB_RS06260
uniprot id: C6A3Z9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS02330
gene id: 604354:TSIB_RS02330
uniprot id: C6A1N6
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

604354:TSIB RS03075
gene id: 604354:TSIB_RS03075
uniprot id: C6A241
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

604354:TSIB RS00800
gene id: 604354:TSIB_RS00800
uniprot id: C6A0T6
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02765
gene id: 604354:TSIB_RS02765
uniprot id: C6A1X6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

604354:TSIB RS05720
gene id: 604354:TSIB_RS05720
uniprot id: C6A3N8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

604354:TSIB RS05915
gene id: 604354:TSIB_RS05915
uniprot id: C6A3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

604354:TSIB RS07825
gene id: 604354:TSIB_RS07825
uniprot id: C6A4W3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

604354:TSIB RS01520
gene id: 604354:TSIB_RS01520
uniprot id: C6A183
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

604354:TSIB RS08735
gene id: 604354:TSIB_RS08735
uniprot id: C6A5F1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

604354:TSIB RS05195
gene id: 604354:TSIB_RS05195
uniprot id: C6A3C8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

604354:TSIB RS04875
gene id: 604354:TSIB_RS04875
uniprot id: C6A365
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

604354:TSIB RS06015
gene id: 604354:TSIB_RS06015
uniprot id: C6A3U9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

604354:TSIB RS04035
gene id: 604354:TSIB_RS04035
uniprot id: C6A2P3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

604354:TSIB RS07560
gene id: 604354:TSIB_RS07560
uniprot id: C6A4R0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS03015
gene id: 604354:TSIB_RS03015
uniprot id: C6A229
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

604354:TSIB RS02185
gene id: 604354:TSIB_RS02185
uniprot id: C6A1K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

604354:TSIB RS04695
gene id: 604354:TSIB_RS04695
uniprot id: C6A325
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01925
gene id: 604354:TSIB_RS01925
uniprot id: C6A1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

604354:TSIB RS05125
gene id: 604354:TSIB_RS05125
uniprot id: C6A3B3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

604354:TSIB RS03055
gene id: 604354:TSIB_RS03055
uniprot id: C6A237
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

604354:TSIB RS05440
gene id: 604354:TSIB_RS05440
uniprot id: C6A3H6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

604354:TSIB RS04955
gene id: 604354:TSIB_RS04955
uniprot id: C6A380
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

604354:TSIB RS09040
gene id: 604354:TSIB_RS09040
uniprot id: C5ZZS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

604354:TSIB RS07485
gene id: 604354:TSIB_RS07485
uniprot id: C6A4P5
names: Similarity
messages: Belongs to the IMPACT family.

604354:TSIB RS06530
gene id: 604354:TSIB_RS06530
uniprot id: C6A452
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

604354:TSIB RS08925
gene id: 604354:TSIB_RS08925
uniprot id: C6A5J0
names: Similarity
messages: Belongs to the carbamate kinase family.

604354:TSIB RS06540
gene id: 604354:TSIB_RS06540
uniprot id: C6A455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

604354:TSIB RS08730
gene id: 604354:TSIB_RS08730
uniprot id: C6A5F0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

604354:TSIB RS01190
gene id: 604354:TSIB_RS01190
uniprot id: C6A116
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

604354:TSIB RS05130
gene id: 604354:TSIB_RS05130
uniprot id: C6A3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

604354:TSIB RS06060
gene id: 604354:TSIB_RS06060
uniprot id: C6A3V8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

604354:TSIB RS04805
gene id: 604354:TSIB_RS04805
uniprot id: C6A349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

604354:TSIB RS06700
gene id: 604354:TSIB_RS06700
uniprot id: C6A486
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

604354:TSIB RS08960
gene id: 604354:TSIB_RS08960
uniprot id: C6A5J7
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS03340
gene id: 604354:TSIB_RS03340
uniprot id: C6A298
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

604354:TSIB RS04915
gene id: 604354:TSIB_RS04915
uniprot id: C6A372
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

604354:TSIB RS09375
gene id: 604354:TSIB_RS09375
uniprot id: C5ZZZ4
names: Subunit
messages: Homotetramer.

604354:TSIB RS01160
gene id: 604354:TSIB_RS01160
uniprot id: C6A110
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS06465
gene id: 604354:TSIB_RS06465
uniprot id: C6A439
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

604354:TSIB RS01680
gene id: 604354:TSIB_RS01680
uniprot id: C6A1B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

604354:TSIB RS03975
gene id: 604354:TSIB_RS03975
uniprot id: C6A2M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS00470
gene id: 604354:TSIB_RS00470
uniprot id: C6A0L7
names: Similarity
messages: Belongs to the HerA family.

604354:TSIB RS07220
gene id: 604354:TSIB_RS07220
uniprot id: C6A4I9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

604354:TSIB RS01545
gene id: 604354:TSIB_RS01545
uniprot id: C6A188
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

604354:TSIB RS05290
gene id: 604354:TSIB_RS05290
uniprot id: C6A3E6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

604354:TSIB RS00280
gene id: 604354:TSIB_RS00280
uniprot id: C6A0I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

604354:TSIB RS05975
gene id: 604354:TSIB_RS05975
uniprot id: C6A3U2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

604354:TSIB RS00500
gene id: 604354:TSIB_RS00500
uniprot id: C6A0M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

604354:TSIB RS00170
gene id: 604354:TSIB_RS00170
uniprot id: C6A0G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

604354:TSIB RS09275
gene id: 604354:TSIB_RS09275
uniprot id: C5ZZX4
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

604354:TSIB RS04490
gene id: 604354:TSIB_RS04490
uniprot id: C6A2Y2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

604354:TSIB RS09615
gene id: 604354:TSIB_RS09615
uniprot id: C6A049
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

604354:TSIB RS03115
gene id: 604354:TSIB_RS03115
uniprot id: C6A249
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

604354:TSIB RS00220
gene id: 604354:TSIB_RS00220
uniprot id: C6A0H0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

604354:TSIB RS03250
gene id: 604354:TSIB_RS03250
uniprot id: C6A279
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

604354:TSIB RS03060
gene id: 604354:TSIB_RS03060
uniprot id: C6A238
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

604354:TSIB RS06165
gene id: 604354:TSIB_RS06165
uniprot id: C6A3Y2
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08725
gene id: 604354:TSIB_RS08725
uniprot id: C6A5E9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

604354:TSIB RS00270
gene id: 604354:TSIB_RS00270
uniprot id: C6A0H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

604354:TSIB RS05270
gene id: 604354:TSIB_RS05270
uniprot id: C6A3E2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

604354:TSIB RS01410
gene id: 604354:TSIB_RS01410
uniprot id: C6A161
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

604354:TSIB RS04075
gene id: 604354:TSIB_RS04075
uniprot id: C6A2Q1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

604354:TSIB RS05540
gene id: 604354:TSIB_RS05540
uniprot id: C6A3J8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

604354:TSIB RS04630
gene id: 604354:TSIB_RS04630
uniprot id: C6A312
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

604354:TSIB RS04375
gene id: 604354:TSIB_RS04375
uniprot id: C6A2V9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

604354:TSIB RS03095
gene id: 604354:TSIB_RS03095
uniprot id: C6A245
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

604354:TSIB RS01045
gene id: 604354:TSIB_RS01045
uniprot id: C6A0Y7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

604354:TSIB RS07310
gene id: 604354:TSIB_RS07310
uniprot id: C6A4L0
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02280
gene id: 604354:TSIB_RS02280
uniprot id: C6A1M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

604354:TSIB RS06140
gene id: 604354:TSIB_RS06140
uniprot id: C6A3X6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

604354:TSIB RS08755
gene id: 604354:TSIB_RS08755
uniprot id: C6A5F5
names: Function
messages: Part of a potassium transport system.

604354:TSIB RS01540
gene id: 604354:TSIB_RS01540
uniprot id: C6A187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

604354:TSIB RS03135
gene id: 604354:TSIB_RS03135
uniprot id: C6A253
names: Similarity
messages: Belongs to the proline racemase family.

604354:TSIB RS05135
gene id: 604354:TSIB_RS05135
uniprot id: C6A3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

604354:TSIB RS02090
gene id: 604354:TSIB_RS02090
uniprot id: C6A1I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

604354:TSIB RS08990
gene id: 604354:TSIB_RS08990
uniprot id: C5ZZR5
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01800
gene id: 604354:TSIB_RS01800
uniprot id: C6A1D9
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS04975
gene id: 604354:TSIB_RS04975
uniprot id: C6A384
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

604354:TSIB RS02445
gene id: 604354:TSIB_RS02445
uniprot id: C6A1R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

604354:TSIB RS06255
gene id: 604354:TSIB_RS06255
uniprot id: C6A3Z8
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS09135
gene id: 604354:TSIB_RS09135
uniprot id: C5ZZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

604354:TSIB RS07995
gene id: 604354:TSIB_RS07995
uniprot id: C6A4Z7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

604354:TSIB RS03350
gene id: 604354:TSIB_RS03350
uniprot id: C6A2A0
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

604354:TSIB RS08270
gene id: 604354:TSIB_RS08270
uniprot id: C6A553
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06815
gene id: 604354:TSIB_RS06815
uniprot id: C6A4B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

604354:TSIB RS01435
gene id: 604354:TSIB_RS01435
uniprot id: C6A166
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

604354:TSIB RS08130
gene id: 604354:TSIB_RS08130
uniprot id: C6A525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

604354:TSIB RS02140
gene id: 604354:TSIB_RS02140
uniprot id: C6A1J9
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

604354:TSIB RS04910
gene id: 604354:TSIB_RS04910
uniprot id: C6A371
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

604354:TSIB RS01360
gene id: 604354:TSIB_RS01360
uniprot id: C6A151
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

604354:TSIB RS02860
gene id: 604354:TSIB_RS02860
uniprot id: C6A1Z6
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

604354:TSIB RS01075
gene id: 604354:TSIB_RS01075
uniprot id: C6A0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS08800
gene id: 604354:TSIB_RS08800
uniprot id: C6A5G4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

604354:TSIB RS09620
gene id: 604354:TSIB_RS09620
uniprot id: C6A050
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS04315
gene id: 604354:TSIB_RS04315
uniprot id: C6A2U9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

604354:TSIB RS05640
gene id: 604354:TSIB_RS05640
uniprot id: C6A3M0
names: Similarity
messages: Belongs to the UPF0215 family.

604354:TSIB RS06010
gene id: 604354:TSIB_RS06010
uniprot id: C6A3U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

604354:TSIB RS07570
gene id: 604354:TSIB_RS07570
uniprot id: C6A4R2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

604354:TSIB RS06155
gene id: 604354:TSIB_RS06155
uniprot id: C6A3X9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS00795
gene id: 604354:TSIB_RS00795
uniprot id: C6A0T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS08630
gene id: 604354:TSIB_RS08630
uniprot id: C6A5C9
names: Similarity
messages: Belongs to the peptidase M20A family.

604354:TSIB RS07265
gene id: 604354:TSIB_RS07265
uniprot id: C6A4K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

604354:TSIB RS08575
gene id: 604354:TSIB_RS08575
uniprot id: C6A5B8
names: Similarity
messages: Belongs to the UPF0216 family.

604354:TSIB RS09540
gene id: 604354:TSIB_RS09540
uniprot id: C6A032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

604354:TSIB RS06420
gene id: 604354:TSIB_RS06420
uniprot id: C6A429
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

604354:TSIB RS02635
gene id: 604354:TSIB_RS02635
uniprot id: C6A1V1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

604354:TSIB RS08045
gene id: 604354:TSIB_RS08045
uniprot id: C6A507
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02980
gene id: 604354:TSIB_RS02980
uniprot id: C6A222
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

604354:TSIB RS08380
gene id: 604354:TSIB_RS08380
uniprot id: C6A576
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

604354:TSIB RS09380
gene id: 604354:TSIB_RS09380
uniprot id: C5ZZZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

604354:TSIB RS07200
gene id: 604354:TSIB_RS07200
uniprot id: C6A4I5
names: Similarity
messages: Belongs to the ZPR1 family.

604354:TSIB RS01610
gene id: 604354:TSIB_RS01610
uniprot id: C6A1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS07290
gene id: 604354:TSIB_RS07290
uniprot id: C6A4K5
names: Similarity
messages: Belongs to the HypE family.

604354:TSIB RS01720
gene id: 604354:TSIB_RS01720
uniprot id: C6A1C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS05430
gene id: 604354:TSIB_RS05430
uniprot id: C6A3H4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

604354:TSIB RS02060
gene id: 604354:TSIB_RS02060
uniprot id: C6A1I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

604354:TSIB RS03030
gene id: 604354:TSIB_RS03030
uniprot id: C6A232
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

604354:TSIB RS04950
gene id: 604354:TSIB_RS04950
uniprot id: C6A379
names: Similarity
messages: Belongs to the UPF0111 family.

604354:TSIB RS01195
gene id: 604354:TSIB_RS01195
uniprot id: C6A117
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

604354:TSIB RS06210
gene id: 604354:TSIB_RS06210
uniprot id: C6A3Y9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

604354:TSIB RS01090
gene id: 604354:TSIB_RS01090
uniprot id: C6A0Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS01205
gene id: 604354:TSIB_RS01205
uniprot id: C6A119
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02565
gene id: 604354:TSIB_RS02565
uniprot id: C6A1T7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

604354:TSIB RS04720
gene id: 604354:TSIB_RS04720
uniprot id: C6A331
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

604354:TSIB RS04235
gene id: 604354:TSIB_RS04235
uniprot id: C6A2T3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS01215
gene id: 604354:TSIB_RS01215
uniprot id: C6A121
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

604354:TSIB RS04670
gene id: 604354:TSIB_RS04670
uniprot id: C6A319
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

604354:TSIB RS06970
gene id: 604354:TSIB_RS06970
uniprot id: C6A4E2
names: Function
names: Subunit
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Homotetramer.

604354:TSIB RS05885
gene id: 604354:TSIB_RS05885
uniprot id: C6A3S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

604354:TSIB RS03905
gene id: 604354:TSIB_RS03905
uniprot id: C6A2L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

604354:TSIB RS06515
gene id: 604354:TSIB_RS06515
uniprot id: C6A449
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

604354:TSIB RS07690
gene id: 604354:TSIB_RS07690
uniprot id: C6A4T6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

604354:TSIB RS04965
gene id: 604354:TSIB_RS04965
uniprot id: C6A382
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

604354:TSIB RS07395
gene id: 604354:TSIB_RS07395
uniprot id: C6A4M7
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

604354:TSIB RS06565
gene id: 604354:TSIB_RS06565
uniprot id: C6A460
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

604354:TSIB RS02605
gene id: 604354:TSIB_RS02605
uniprot id: C6A1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS00035
gene id: 604354:TSIB_RS00035
uniprot id: C6A0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

604354:TSIB RS02430
gene id: 604354:TSIB_RS02430
uniprot id: C6A1Q9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

604354:TSIB RS06330
gene id: 604354:TSIB_RS06330
uniprot id: C6A413
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS00460
gene id: 604354:TSIB_RS00460
uniprot id: C6A0L5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

604354:TSIB RS01490
gene id: 604354:TSIB_RS01490
uniprot id: C6A177
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

604354:TSIB RS00245
gene id: 604354:TSIB_RS00245
uniprot id: C6A0H5
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

604354:TSIB RS08870
gene id: 604354:TSIB_RS08870
uniprot id: C6A5H9
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08780
gene id: 604354:TSIB_RS08780
uniprot id: C6A5G0
names: Similarity
messages: Belongs to the UPF0273 family.

604354:TSIB RS01890
gene id: 604354:TSIB_RS01890
uniprot id: C6A1F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

604354:TSIB RS08360
gene id: 604354:TSIB_RS08360
uniprot id: C6A572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

604354:TSIB RS09100
gene id: 604354:TSIB_RS09100
uniprot id: C5ZZT8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

604354:TSIB RS08645
gene id: 604354:TSIB_RS08645
uniprot id: C6A5D2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

604354:TSIB RS02720
gene id: 604354:TSIB_RS02720
uniprot id: C6A1W7
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

604354:TSIB RS07515
gene id: 604354:TSIB_RS07515
uniprot id: C6A4Q1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

604354:TSIB RS00425
gene id: 604354:TSIB_RS00425
uniprot id: C6A0K8
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06180
gene id: 604354:TSIB_RS06180
uniprot id: C6A3Y5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

604354:TSIB RS04205
gene id: 604354:TSIB_RS04205
uniprot id: C6A2S7
names: Similarity
messages: Belongs to the UPF0173 family.

604354:TSIB RS06590
gene id: 604354:TSIB_RS06590
uniprot id: C6A465
names: Similarity
messages: Belongs to the UPF0212 family.

604354:TSIB RS09060
gene id: 604354:TSIB_RS09060
uniprot id: C5ZZT0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

604354:TSIB RS05320
gene id: 604354:TSIB_RS05320
uniprot id: C6A3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

604354:TSIB RS02480
gene id: 604354:TSIB_RS02480
uniprot id: C6A1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

604354:TSIB RS00150
gene id: 604354:TSIB_RS00150
uniprot id: C6A0F6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS01250
gene id: 604354:TSIB_RS01250
uniprot id: C6A130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

604354:TSIB RS08220
gene id: 604354:TSIB_RS08220
uniprot id: C6A542
names: Similarity
messages: Belongs to the AOR/FOR family.

604354:TSIB RS05835
gene id: 604354:TSIB_RS05835
uniprot id: C6A3R1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

604354:TSIB RS06415
gene id: 604354:TSIB_RS06415
uniprot id: C6A428
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

604354:TSIB RS00985
gene id: 604354:TSIB_RS00985
uniprot id: C6A0X6
names: Similarity
messages: Belongs to the UPF0282 family.

604354:TSIB RS06710
gene id: 604354:TSIB_RS06710
uniprot id: C6A488
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

604354:TSIB RS03050
gene id: 604354:TSIB_RS03050
uniprot id: C6A236
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

604354:TSIB RS03080
gene id: 604354:TSIB_RS03080
uniprot id: C6A242
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS03695
gene id: 604354:TSIB_RS03695
uniprot id: C6A2G8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS09420
gene id: 604354:TSIB_RS09420
uniprot id: C6A003
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

604354:TSIB RS01930
gene id: 604354:TSIB_RS01930
uniprot id: C6A1G0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

604354:TSIB RS03810
gene id: 604354:TSIB_RS03810
uniprot id: C6A2J3
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06225
gene id: 604354:TSIB_RS06225
uniprot id: C6A3Z2
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS05415
gene id: 604354:TSIB_RS05415
uniprot id: C6A3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

604354:TSIB RS00600
gene id: 604354:TSIB_RS00600
uniprot id: C6A0P2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS01495
gene id: 604354:TSIB_RS01495
uniprot id: C6A178
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

604354:TSIB RS06645
gene id: 604354:TSIB_RS06645
uniprot id: C6A475
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS00405
gene id: 604354:TSIB_RS00405
uniprot id: C6A0K5
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

604354:TSIB RS06295
gene id: 604354:TSIB_RS06295
uniprot id: C6A406
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07170
gene id: 604354:TSIB_RS07170
uniprot id: C6A4I1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

604354:TSIB RS01120
gene id: 604354:TSIB_RS01120
uniprot id: C6A102
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

604354:TSIB RS07865
gene id: 604354:TSIB_RS07865
uniprot id: C6A4X1
names: Similarity
messages: Belongs to the UPF0310 family.

604354:TSIB RS04495
gene id: 604354:TSIB_RS04495
uniprot id: C6A2Y3
names: Similarity
messages: Belongs to the UPF0200 family.

604354:TSIB RS07380
gene id: 604354:TSIB_RS07380
uniprot id: C6A4M4
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

604354:TSIB RS07210
gene id: 604354:TSIB_RS07210
uniprot id: C6A4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

604354:TSIB RS00265
gene id: 604354:TSIB_RS00265
uniprot id: C6A0H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

604354:TSIB RS00780
gene id: 604354:TSIB_RS00780
uniprot id: C6A0T2
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

604354:TSIB RS06685
gene id: 604354:TSIB_RS06685
uniprot id: C6A483
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

604354:TSIB RS06160
gene id: 604354:TSIB_RS06160
uniprot id: C6A3Y1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

604354:TSIB RS04400
gene id: 604354:TSIB_RS04400
uniprot id: C6A2W4
names: Similarity
messages: Belongs to the UPF0252 family.

604354:TSIB RS05115
gene id: 604354:TSIB_RS05115
uniprot id: C6A3B1
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

604354:TSIB RS07150
gene id: 604354:TSIB_RS07150
uniprot id: C6A4H7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

604354:TSIB RS10105
gene id: 604354:TSIB_RS10105
uniprot id: C6A4J6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

604354:TSIB RS05965
gene id: 604354:TSIB_RS05965
uniprot id: C6A3U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

604354:TSIB RS04645
gene id: 604354:TSIB_RS04645
uniprot id: C6A315
names: Similarity
messages: Belongs to the UPF0235 family.

604354:TSIB RS02645
gene id: 604354:TSIB_RS02645
uniprot id: C6A1V3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

604354:TSIB RS06555
gene id: 604354:TSIB_RS06555
uniprot id: C6A458
names: Similarity
messages: Belongs to the SDO1/SBDS family.

604354:TSIB RS07530
gene id: 604354:TSIB_RS07530
uniprot id: C6A4Q4
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06185
gene id: 604354:TSIB_RS06185
uniprot id: C6A3Y6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

604354:TSIB RS07790
gene id: 604354:TSIB_RS07790
uniprot id: C6A4V6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

604354:TSIB RS04485
gene id: 604354:TSIB_RS04485
uniprot id: C6A2Y1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

604354:TSIB RS07450
gene id: 604354:TSIB_RS07450
uniprot id: C6A4N8
names: Similarity
messages: Belongs to the MCM family.

604354:TSIB RS09220
gene id: 604354:TSIB_RS09220
uniprot id: C5ZZW3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

604354:TSIB RS01775
gene id: 604354:TSIB_RS01775
uniprot id: C6A1D4
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06430
gene id: 604354:TSIB_RS06430
uniprot id: C6A431
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06135
gene id: 604354:TSIB_RS06135
uniprot id: C6A3X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

604354:TSIB RS02020
gene id: 604354:TSIB_RS02020
uniprot id: C6A1H6
names: Similarity
messages: Belongs to the FUN14 family.

604354:TSIB RS07475
gene id: 604354:TSIB_RS07475
uniprot id: C6A4P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS06715
gene id: 604354:TSIB_RS06715
uniprot id: C6A489
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

604354:TSIB RS07440
gene id: 604354:TSIB_RS07440
uniprot id: C6A4N6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

604354:TSIB RS09370
gene id: 604354:TSIB_RS09370
uniprot id: C5ZZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

604354:TSIB RS05470
gene id: 604354:TSIB_RS05470
uniprot id: C6A3I3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

604354:TSIB RS00730
gene id: 604354:TSIB_RS00730
uniprot id: C6A0S1
names: Similarity
messages: Belongs to the thymidylate kinase family.

604354:TSIB RS00715
gene id: 604354:TSIB_RS00715
uniprot id: C6A0R8
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

604354:TSIB RS05410
gene id: 604354:TSIB_RS05410
uniprot id: C6A3G9
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

604354:TSIB RS01615
gene id: 604354:TSIB_RS01615
uniprot id: C6A1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

604354:TSIB RS08485
gene id: 604354:TSIB_RS08485
uniprot id: C6A598
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

604354:TSIB RS04125
gene id: 604354:TSIB_RS04125
uniprot id: C6A2R1
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08285
gene id: 604354:TSIB_RS08285
uniprot id: C6A556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

604354:TSIB RS09495
gene id: 604354:TSIB_RS09495
uniprot id: C6A023
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS00640
gene id: 604354:TSIB_RS00640
uniprot id: C6A0Q1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

604354:TSIB RS02425
gene id: 604354:TSIB_RS02425
uniprot id: C6A1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

604354:TSIB RS06405
gene id: 604354:TSIB_RS06405
uniprot id: C6A426
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01705
gene id: 604354:TSIB_RS01705
uniprot id: C6A1B9
names: Similarity
messages: Belongs to the enolase family.

604354:TSIB RS04560
gene id: 604354:TSIB_RS04560
uniprot id: C6A2Z8
names: Similarity
messages: Belongs to the peptidase U62 family.

604354:TSIB RS02085
gene id: 604354:TSIB_RS02085
uniprot id: C6A1I8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS06550
gene id: 604354:TSIB_RS06550
uniprot id: C6A457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

604354:TSIB RS09400
gene id: 604354:TSIB_RS09400
uniprot id: C5ZZZ9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

604354:TSIB RS05900
gene id: 604354:TSIB_RS05900
uniprot id: C6A3S5
names: Similarity
messages: Belongs to the SfsA family.

604354:TSIB RS01425
gene id: 604354:TSIB_RS01425
uniprot id: C6A164
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

604354:TSIB RS09175
gene id: 604354:TSIB_RS09175
uniprot id: C5ZZV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS06845
gene id: 604354:TSIB_RS06845
uniprot id: C6A4B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

604354:TSIB RS07255
gene id: 604354:TSIB_RS07255
uniprot id: C6A4J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

604354:TSIB RS06695
gene id: 604354:TSIB_RS06695
uniprot id: C6A485
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

604354:TSIB RS01655
gene id: 604354:TSIB_RS01655
uniprot id: C6A1B1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

604354:TSIB RS07700
gene id: 604354:TSIB_RS07700
uniprot id: C6A4T9
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS06100
gene id: 604354:TSIB_RS06100
uniprot id: C6A3W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

604354:TSIB RS05110
gene id: 604354:TSIB_RS05110
uniprot id: C6A3B0
names: Similarity
messages: Belongs to the peptidase S9C family.

604354:TSIB RS02200
gene id: 604354:TSIB_RS02200
uniprot id: C6A1L1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

604354:TSIB RS00645
gene id: 604354:TSIB_RS00645
uniprot id: C6A0Q2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

604354:TSIB RS09965
gene id: 604354:TSIB_RS09965
uniprot id: C6A0B7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

604354:TSIB RS05285
gene id: 604354:TSIB_RS05285
uniprot id: C6A3E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

604354:TSIB RS09850
gene id: 604354:TSIB_RS09850
uniprot id: C6A094
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

604354:TSIB RS03580
gene id: 604354:TSIB_RS03580
uniprot id: C6A2E5
names: Similarity
messages: Belongs to the UPF0179 family.

604354:TSIB RS03645
gene id: 604354:TSIB_RS03645
uniprot id: C6A2F8
names: Similarity
messages: Belongs to the UPF0252 family.

604354:TSIB RS02775
gene id: 604354:TSIB_RS02775
uniprot id: C6A1X8
names: Similarity
messages: Belongs to the HerA family.

604354:TSIB RS03130
gene id: 604354:TSIB_RS03130
uniprot id: C6A252
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS03730
gene id: 604354:TSIB_RS03730
uniprot id: C6A2H5
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS08595
gene id: 604354:TSIB_RS08595
uniprot id: C6A5C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

604354:TSIB RS01760
gene id: 604354:TSIB_RS01760
uniprot id: C6A1D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

604354:TSIB RS09450
gene id: 604354:TSIB_RS09450
uniprot id: C6A011
names: Similarity
messages: Belongs to the UPF0107 family.

604354:TSIB RS02540
gene id: 604354:TSIB_RS02540
uniprot id: C6A1T2
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

604354:TSIB RS04165
gene id: 604354:TSIB_RS04165
uniprot id: C6A2R9
names: Subcellular Location Annotation
messages: Cell membrane

604354:TSIB RS01500
gene id: 604354:TSIB_RS01500
uniprot id: C6A179
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

604354:TSIB RS05580
gene id: 604354:TSIB_RS05580
uniprot id: C6A3K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

604354:TSIB RS07015
gene id: 604354:TSIB_RS07015
uniprot id: C6A4F1
names: Similarity
messages: Belongs to the UPF0248 family.

604354:TSIB RS09215
gene id: 604354:TSIB_RS09215
uniprot id: C5ZZW2
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

604354:TSIB RS04395
gene id: 604354:TSIB_RS04395
uniprot id: C6A2W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

604354:TSIB RS05590
gene id: 604354:TSIB_RS05590
uniprot id: C6A3K9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

604354:TSIB RS05190
gene id: 604354:TSIB_RS05190
uniprot id: C6A3C7
names: Similarity
messages: Belongs to the threonine synthase family.

604354:TSIB RS09305
gene id: 604354:TSIB_RS09305
uniprot id: C5ZZY0
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS02240
gene id: 604354:TSIB_RS02240
uniprot id: C6A1L9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

604354:TSIB RS02220
gene id: 604354:TSIB_RS02220
uniprot id: C6A1L5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

604354:TSIB RS08105
gene id: 604354:TSIB_RS08105
uniprot id: C6A519
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

604354:TSIB RS05815
gene id: 604354:TSIB_RS05815
uniprot id: C6A3Q7
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

604354:TSIB RS09330
gene id: 604354:TSIB_RS09330
uniprot id: C5ZZY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS00680
gene id: 604354:TSIB_RS00680
uniprot id: C6A0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

604354:TSIB RS02900
gene id: 604354:TSIB_RS02900
uniprot id: C6A204
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

604354:TSIB RS09945
gene id: 604354:TSIB_RS09945
uniprot id: C6A0B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

604354:TSIB RS03180
gene id: 604354:TSIB_RS03180
uniprot id: C6A264
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

604354:TSIB RS06780
gene id: 604354:TSIB_RS06780
uniprot id: C6A4A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

604354:TSIB RS09955
gene id: 604354:TSIB_RS09955
uniprot id: C6A0B5
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS01995
gene id: 604354:TSIB_RS01995
uniprot id: C6A1H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

604354:TSIB RS01880
gene id: 604354:TSIB_RS01880
uniprot id: C6A1F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

604354:TSIB RS00140
gene id: 604354:TSIB_RS00140
uniprot id: C6A0F4
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

604354:TSIB RS05945
gene id: 604354:TSIB_RS05945
uniprot id: C6A3T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

604354:TSIB RS05960
gene id: 604354:TSIB_RS05960
uniprot id: C6A3T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

604354:TSIB RS04765
gene id: 604354:TSIB_RS04765
uniprot id: C6A341
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS09070
gene id: 604354:TSIB_RS09070
uniprot id: C5ZZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

604354:TSIB RS04905
gene id: 604354:TSIB_RS04905
uniprot id: C6A370
names: Similarity
messages: Belongs to the AOR/FOR family.

604354:TSIB RS00240
gene id: 604354:TSIB_RS00240
uniprot id: C6A0H4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

604354:TSIB RS00720
gene id: 604354:TSIB_RS00720
uniprot id: C6A0R9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

604354:TSIB RS00610
gene id: 604354:TSIB_RS00610
uniprot id: C6A0P4
names: Similarity
messages: Belongs to the DtxR/MntR family.

604354:TSIB RS07235
gene id: 604354:TSIB_RS07235
uniprot id: C6A4J4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

604354:TSIB RS05545
gene id: 604354:TSIB_RS05545
uniprot id: C6A3J9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

604354:TSIB RS03175
gene id: 604354:TSIB_RS03175
uniprot id: C6A262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

604354:TSIB RS04095
gene id: 604354:TSIB_RS04095
uniprot id: C6A2Q5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

604354:TSIB RS00145
gene id: 604354:TSIB_RS00145
uniprot id: C6A0F5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

604354:TSIB RS07385
gene id: 604354:TSIB_RS07385
uniprot id: C6A4M5
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

604354:TSIB RS06320
gene id: 604354:TSIB_RS06320
uniprot id: C6A411
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07325
gene id: 604354:TSIB_RS07325
uniprot id: C6A4L3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

604354:TSIB RS08710
gene id: 604354:TSIB_RS08710
uniprot id: C6A5E6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

604354:TSIB RS08060
gene id: 604354:TSIB_RS08060
uniprot id: C6A510
names: Similarity
messages: Belongs to the UPF0047 family.

604354:TSIB RS04945
gene id: 604354:TSIB_RS04945
uniprot id: C6A378
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

604354:TSIB RS07550
gene id: 604354:TSIB_RS07550
uniprot id: C6A4Q8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

604354:TSIB RS04940
gene id: 604354:TSIB_RS04940
uniprot id: C6A377
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

604354:TSIB RS01505
gene id: 604354:TSIB_RS01505
uniprot id: C6A180
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

604354:TSIB RS07850
gene id: 604354:TSIB_RS07850
uniprot id: C6A4W8
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

604354:TSIB RS06560
gene id: 604354:TSIB_RS06560
uniprot id: C6A459
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

604354:TSIB RS07670
gene id: 604354:TSIB_RS07670
uniprot id: C6A4T2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

604354:TSIB RS04960
gene id: 604354:TSIB_RS04960
uniprot id: C6A381
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

604354:TSIB RS02105
gene id: 604354:TSIB_RS02105
uniprot id: C6A1J2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

604354:TSIB RS07115
gene id: 604354:TSIB_RS07115
uniprot id: C6A4H0
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

604354:TSIB RS00495
gene id: 604354:TSIB_RS00495
uniprot id: C6A0M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

604354:TSIB RS00785
gene id: 604354:TSIB_RS00785
uniprot id: C6A0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

604354:TSIB RS01275
gene id: 604354:TSIB_RS01275
uniprot id: C6A135
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

604354:TSIB RS09010
gene id: 604354:TSIB_RS09010
uniprot id: C5ZZS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

604354:TSIB RS00290
gene id: 604354:TSIB_RS00290
uniprot id: C6A0I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

604354:TSIB RS03915
gene id: 604354:TSIB_RS03915
uniprot id: C6A2L5
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

604354:TSIB RS06410
gene id: 604354:TSIB_RS06410
uniprot id: C6A427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

604354:TSIB RS02225
gene id: 604354:TSIB_RS02225
uniprot id: C6A1L6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

604354:TSIB RS00745
gene id: 604354:TSIB_RS00745
uniprot id: C6A0S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

604354:TSIB RS06035
gene id: 604354:TSIB_RS06035
uniprot id: C6A3V3
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

604354:TSIB RS05280
gene id: 604354:TSIB_RS05280
uniprot id: C6A3E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

604354:TSIB RS05555
gene id: 604354:TSIB_RS05555
uniprot id: C6A3K1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

604354:TSIB RS01130
gene id: 604354:TSIB_RS01130
uniprot id: C6A104
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07740
gene id: 604354:TSIB_RS07740
uniprot id: C6A4U6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

604354:TSIB RS00655
gene id: 604354:TSIB_RS00655
uniprot id: C6A0Q4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

604354:TSIB RS03760
gene id: 604354:TSIB_RS03760
uniprot id: C6A2I3
names: Similarity
messages: Belongs to the HypE family.

604354:TSIB RS07330
gene id: 604354:TSIB_RS07330
uniprot id: C6A4L4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

604354:TSIB RS04335
gene id: 604354:TSIB_RS04335
uniprot id: C6A2V1
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

604354:TSIB RS03635
gene id: 604354:TSIB_RS03635
uniprot id: C6A2F6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

604354:TSIB RS01580
gene id: 604354:TSIB_RS01580
uniprot id: C6A195
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

604354:TSIB RS08740
gene id: 604354:TSIB_RS08740
uniprot id: C6A5F2
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07905
gene id: 604354:TSIB_RS07905
uniprot id: C6A4X9
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

604354:TSIB RS00315
gene id: 604354:TSIB_RS00315
uniprot id: C6A0I6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS07920
gene id: 604354:TSIB_RS07920
uniprot id: C6A4Y2
names: Similarity
messages: Belongs to the AOR/FOR family.

604354:TSIB RS08655
gene id: 604354:TSIB_RS08655
uniprot id: C6A5D5
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

604354:TSIB RS00540
gene id: 604354:TSIB_RS00540
uniprot id: C6A0N1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

604354:TSIB RS04830
gene id: 604354:TSIB_RS04830
uniprot id: C6A354
names: Similarity
messages: Belongs to the glutaredoxin family.

604354:TSIB RS01210
gene id: 604354:TSIB_RS01210
uniprot id: C6A120
names: Similarity
messages: Belongs to the phosphohexose mutase family.

604354:TSIB RS02045
gene id: 604354:TSIB_RS02045
uniprot id: C6A1I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

604354:TSIB RS01465
gene id: 604354:TSIB_RS01465
uniprot id: C6A172
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

604354:TSIB RS01460
gene id: 604354:TSIB_RS01460
uniprot id: C6A171
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

604354:TSIB RS00430
gene id: 604354:TSIB_RS00430
uniprot id: C6A0K9
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS07090
gene id: 604354:TSIB_RS07090
uniprot id: C6A4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

604354:TSIB RS02440
gene id: 604354:TSIB_RS02440
uniprot id: C6A1R1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

604354:TSIB RS01430
gene id: 604354:TSIB_RS01430
uniprot id: C6A165
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

604354:TSIB RS09290
gene id: 604354:TSIB_RS09290
uniprot id: C5ZZX7
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS04210
gene id: 604354:TSIB_RS04210
uniprot id: C6A2S8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

604354:TSIB RS06795
gene id: 604354:TSIB_RS06795
uniprot id: C6A4A6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

604354:TSIB RS02195
gene id: 604354:TSIB_RS02195
uniprot id: C6A1L0
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

604354:TSIB RS09730
gene id: 604354:TSIB_RS09730
uniprot id: C6A073
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

604354:TSIB RS02100
gene id: 604354:TSIB_RS02100
uniprot id: C6A1J1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

604354:TSIB RS01315
gene id: 604354:TSIB_RS01315
uniprot id: C6A143
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

604354:TSIB RS02175
gene id: 604354:TSIB_RS02175
uniprot id: C6A1K6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

604354:TSIB RS06325
gene id: 604354:TSIB_RS06325
uniprot id: C6A412
names: Subcellular Location Annotation
messages: Membrane

604354:TSIB RS03550
gene id: 604354:TSIB_RS03550
uniprot id: C6A2E0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

604354:TSIB RS08760
gene id: 604354:TSIB_RS08760
uniprot id: C6A5F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

604354:TSIB RS04150
gene id: 604354:TSIB_RS04150
uniprot id: C6A2R6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

604354:TSIB RS09150
gene id: 604354:TSIB_RS09150
uniprot id: C5ZZU8
names: Similarity
messages: Belongs to the PstS family.