591019:SHELL RS01390
gene id: 591019:SHELL_RS01390
uniprot id: D7DB63
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

591019:SHELL RS06615
gene id: 591019:SHELL_RS06615
uniprot id: D7D9J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

591019:SHELL RS03310
gene id: 591019:SHELL_RS03310
uniprot id: D7DC96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

591019:SHELL RS03490
gene id: 591019:SHELL_RS03490
uniprot id: D7DCD1
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07580
gene id: 591019:SHELL_RS07580
uniprot id: D7DA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS07940
gene id: 591019:SHELL_RS07940
uniprot id: D7DAA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

591019:SHELL RS06465
gene id: 591019:SHELL_RS06465
uniprot id: D7D9H3
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS06285
gene id: 591019:SHELL_RS06285
uniprot id: D7D9E4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

591019:SHELL RS00115
gene id: 591019:SHELL_RS00115
uniprot id: D7DAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

591019:SHELL RS00015
gene id: 591019:SHELL_RS00015
uniprot id: D7DAF8
names: Similarity
messages: Belongs to the UPF0215 family.

591019:SHELL RS05495
gene id: 591019:SHELL_RS05495
uniprot id: D7D8Y8
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

591019:SHELL RS04625
gene id: 591019:SHELL_RS04625
uniprot id: D7D8G1
names: Similarity
messages: Belongs to the peptidase U62 family.

591019:SHELL RS02685
gene id: 591019:SHELL_RS02685
uniprot id: D7DBX2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

591019:SHELL RS02270
gene id: 591019:SHELL_RS02270
uniprot id: D7DBN8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

591019:SHELL RS00705
gene id: 591019:SHELL_RS00705
uniprot id: D7DAT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591019:SHELL RS01480
gene id: 591019:SHELL_RS01480
uniprot id: D7DB81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

591019:SHELL RS06780
gene id: 591019:SHELL_RS06780
uniprot id: D7D9M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

591019:SHELL RS04905
gene id: 591019:SHELL_RS04905
uniprot id: D7D8L8
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS01305
gene id: 591019:SHELL_RS01305
uniprot id: D7DB47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

591019:SHELL RS04535
gene id: 591019:SHELL_RS04535
uniprot id: D7D8E3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

591019:SHELL RS07055
gene id: 591019:SHELL_RS07055
uniprot id: D7D9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

591019:SHELL RS08115
gene id: 591019:SHELL_RS08115
uniprot id: D7DAD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

591019:SHELL RS02870
gene id: 591019:SHELL_RS02870
uniprot id: D7DC08
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

591019:SHELL RS05095
gene id: 591019:SHELL_RS05095
uniprot id: D7D8Q7
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS06705
gene id: 591019:SHELL_RS06705
uniprot id: D7D9L3
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS03410
gene id: 591019:SHELL_RS03410
uniprot id: D7DCB5
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07865
gene id: 591019:SHELL_RS07865
uniprot id: D7DA89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

591019:SHELL RS07060
gene id: 591019:SHELL_RS07060
uniprot id: D7D9S9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

591019:SHELL RS00445
gene id: 591019:SHELL_RS00445
uniprot id: D7DAN8
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.

591019:SHELL RS00365
gene id: 591019:SHELL_RS00365
uniprot id: D7DAM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

591019:SHELL RS00680
gene id: 591019:SHELL_RS00680
uniprot id: D7DAT0
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07895
gene id: 591019:SHELL_RS07895
uniprot id: D7DA93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

591019:SHELL RS03060
gene id: 591019:SHELL_RS03060
uniprot id: D7DC47
names: Similarity
messages: Belongs to the phosphohexose mutase family.

591019:SHELL RS02300
gene id: 591019:SHELL_RS02300
uniprot id: D7DBP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS05730
gene id: 591019:SHELL_RS05730
uniprot id: D7D936
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07475
gene id: 591019:SHELL_RS07475
uniprot id: D7DA13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

591019:SHELL RS07915
gene id: 591019:SHELL_RS07915
uniprot id: D7DA97
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

591019:SHELL RS07180
gene id: 591019:SHELL_RS07180
uniprot id: D7D9V5
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

591019:SHELL RS07975
gene id: 591019:SHELL_RS07975
uniprot id: D7DAA8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

591019:SHELL RS02735
gene id: 591019:SHELL_RS02735
uniprot id: D7DBY3
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

591019:SHELL RS06825
gene id: 591019:SHELL_RS06825
uniprot id: D7D9N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS06685
gene id: 591019:SHELL_RS06685
uniprot id: D7D9K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

591019:SHELL RS03745
gene id: 591019:SHELL_RS03745
uniprot id: D7D7Y1
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS05060
gene id: 591019:SHELL_RS05060
uniprot id: D7D8Q0
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS05915
gene id: 591019:SHELL_RS05915
uniprot id: D7D972
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

591019:SHELL RS02525
gene id: 591019:SHELL_RS02525
uniprot id: D7DBU0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

591019:SHELL RS03765
gene id: 591019:SHELL_RS03765
uniprot id: D7D7Y5
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS06560
gene id: 591019:SHELL_RS06560
uniprot id: D7D9J1
names: Similarity
messages: Belongs to the UPF0273 family.

591019:SHELL RS04480
gene id: 591019:SHELL_RS04480
uniprot id: D7D8D2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

591019:SHELL RS02365
gene id: 591019:SHELL_RS02365
uniprot id: D7DBQ7
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

591019:SHELL RS00725
gene id: 591019:SHELL_RS00725
uniprot id: D7DAT9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

591019:SHELL RS03360
gene id: 591019:SHELL_RS03360
uniprot id: D7DCA6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

591019:SHELL RS07495
gene id: 591019:SHELL_RS07495
uniprot id: D7DA17
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

591019:SHELL RS07990
gene id: 591019:SHELL_RS07990
uniprot id: D7DAB1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

591019:SHELL RS08110
gene id: 591019:SHELL_RS08110
uniprot id: D7DAD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

591019:SHELL RS08190
gene id: 591019:SHELL_RS08190
uniprot id: D7DAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

591019:SHELL RS07245
gene id: 591019:SHELL_RS07245
uniprot id: D7D9W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

591019:SHELL RS02330
gene id: 591019:SHELL_RS02330
uniprot id: D7DBQ0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

591019:SHELL RS08185
gene id: 591019:SHELL_RS08185
uniprot id: D7DAE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS02705
gene id: 591019:SHELL_RS02705
uniprot id: D7DBX7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

591019:SHELL RS00620
gene id: 591019:SHELL_RS00620
uniprot id: D7DAS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

591019:SHELL RS06500
gene id: 591019:SHELL_RS06500
uniprot id: D7D9H9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

591019:SHELL RS07780
gene id: 591019:SHELL_RS07780
uniprot id: D7DA72
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

591019:SHELL RS00675
gene id: 591019:SHELL_RS00675
uniprot id: D7DAS9
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS06735
gene id: 591019:SHELL_RS06735
uniprot id: D7D9L9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

591019:SHELL RS02645
gene id: 591019:SHELL_RS02645
uniprot id: D7DBW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS00525
gene id: 591019:SHELL_RS00525
uniprot id: D7DAQ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

591019:SHELL RS05280
gene id: 591019:SHELL_RS05280
uniprot id: D7D8U5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

591019:SHELL RS02675
gene id: 591019:SHELL_RS02675
uniprot id: D7DBX0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

591019:SHELL RS02340
gene id: 591019:SHELL_RS02340
uniprot id: D7DBQ2
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

591019:SHELL RS02965
gene id: 591019:SHELL_RS02965
uniprot id: D7DC29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS07920
gene id: 591019:SHELL_RS07920
uniprot id: D7DA98
names: Function
messages: Probably involved in the biogenesis of the ribosome.

591019:SHELL RS04025
gene id: 591019:SHELL_RS04025
uniprot id: D7D838
names: Similarity
messages: Belongs to the AOR/FOR family.

591019:SHELL RS07250
gene id: 591019:SHELL_RS07250
uniprot id: D7D9W8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

591019:SHELL RS06485
gene id: 591019:SHELL_RS06485
uniprot id: D7D9H6
names: Similarity
messages: Belongs to the SUI1 family.

591019:SHELL RS05905
gene id: 591019:SHELL_RS05905
uniprot id: D7D970
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

591019:SHELL RS08015
gene id: 591019:SHELL_RS08015
uniprot id: D7DAB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

591019:SHELL RS06520
gene id: 591019:SHELL_RS06520
uniprot id: D7D9I3
names: Similarity
messages: Belongs to the UPF0111 family.

591019:SHELL RS07290
gene id: 591019:SHELL_RS07290
uniprot id: D7D9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS05395
gene id: 591019:SHELL_RS05395
uniprot id: D7D8W9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

591019:SHELL RS01110
gene id: 591019:SHELL_RS01110
uniprot id: D7DB12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

591019:SHELL RS02095
gene id: 591019:SHELL_RS02095
uniprot id: D7DBK3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

591019:SHELL RS02920
gene id: 591019:SHELL_RS02920
uniprot id: D7DC19
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

591019:SHELL RS08050
gene id: 591019:SHELL_RS08050
uniprot id: D7DAB9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS00050
gene id: 591019:SHELL_RS00050
uniprot id: D7DAG3
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS07035
gene id: 591019:SHELL_RS07035
uniprot id: D7D9S4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

591019:SHELL RS03215
gene id: 591019:SHELL_RS03215
uniprot id: D7DC77
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS03425
gene id: 591019:SHELL_RS03425
uniprot id: D7DCB8
names: Similarity
messages: Belongs to the UPF0047 family.

591019:SHELL RS05085
gene id: 591019:SHELL_RS05085
uniprot id: D7D8Q5
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS03590
gene id: 591019:SHELL_RS03590
uniprot id: D7DCF0
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

591019:SHELL RS06375
gene id: 591019:SHELL_RS06375
uniprot id: D7D9G2
names: Similarity
messages: Belongs to the PGI/PMI family.

591019:SHELL RS08080
gene id: 591019:SHELL_RS08080
uniprot id: D7DAC5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

591019:SHELL RS06380
gene id: 591019:SHELL_RS06380
uniprot id: D7D9G3
names: Subcellular Location Annotation
messages: Cell membrane

591019:SHELL RS07505
gene id: 591019:SHELL_RS07505
uniprot id: D7DA19
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

591019:SHELL RS07430
gene id: 591019:SHELL_RS07430
uniprot id: D7DA05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

591019:SHELL RS01240
gene id: 591019:SHELL_RS01240
uniprot id: D7DB33
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

591019:SHELL RS00905
gene id: 591019:SHELL_RS00905
uniprot id: D7DAX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS03535
gene id: 591019:SHELL_RS03535
uniprot id: D7DCE1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

591019:SHELL RS01655
gene id: 591019:SHELL_RS01655
uniprot id: D7DBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

591019:SHELL RS03760
gene id: 591019:SHELL_RS03760
uniprot id: D7D7Y4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS02835
gene id: 591019:SHELL_RS02835
uniprot id: D7DC01
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

591019:SHELL RS01710
gene id: 591019:SHELL_RS01710
uniprot id: D7DBC9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

591019:SHELL RS07385
gene id: 591019:SHELL_RS07385
uniprot id: D7D9Z5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

591019:SHELL RS03680
gene id: 591019:SHELL_RS03680
uniprot id: D7DCG7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591019:SHELL RS07025
gene id: 591019:SHELL_RS07025
uniprot id: D7D9S2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS06155
gene id: 591019:SHELL_RS06155
uniprot id: D7D9B8
names: Similarity
messages: Belongs to the AOR/FOR family.

591019:SHELL RS00780
gene id: 591019:SHELL_RS00780
uniprot id: D7DAV1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

591019:SHELL RS07675
gene id: 591019:SHELL_RS07675
uniprot id: D7DA51
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

591019:SHELL RS06385
gene id: 591019:SHELL_RS06385
uniprot id: D7D9G4
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

591019:SHELL RS01595
gene id: 591019:SHELL_RS01595
uniprot id: D7DBA4
names: Similarity
messages: Belongs to the CutA family.

591019:SHELL RS06490
gene id: 591019:SHELL_RS06490
uniprot id: D7D9H7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS01100
gene id: 591019:SHELL_RS01100
uniprot id: D7DB10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

591019:SHELL RS05920
gene id: 591019:SHELL_RS05920
uniprot id: D7D973
names: Similarity
messages: Belongs to the UPF0201 family.

591019:SHELL RS05675
gene id: 591019:SHELL_RS05675
uniprot id: D7D925
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

591019:SHELL RS06610
gene id: 591019:SHELL_RS06610
uniprot id: D7D9J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

591019:SHELL RS01105
gene id: 591019:SHELL_RS01105
uniprot id: D7DB11
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

591019:SHELL RS06065
gene id: 591019:SHELL_RS06065
uniprot id: D7D9A1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

591019:SHELL RS07315
gene id: 591019:SHELL_RS07315
uniprot id: D7D9Y1
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS00695
gene id: 591019:SHELL_RS00695
uniprot id: D7DAT3
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07925
gene id: 591019:SHELL_RS07925
uniprot id: D7DA99
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS06150
gene id: 591019:SHELL_RS06150
uniprot id: D7D9B7
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.

591019:SHELL RS01670
gene id: 591019:SHELL_RS01670
uniprot id: D7DBC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

591019:SHELL RS06925
gene id: 591019:SHELL_RS06925
uniprot id: D7D9Q3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

591019:SHELL RS04835
gene id: 591019:SHELL_RS04835
uniprot id: D7D8K5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

591019:SHELL RS08035
gene id: 591019:SHELL_RS08035
uniprot id: D7DAB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

591019:SHELL RS05930
gene id: 591019:SHELL_RS05930
uniprot id: D7D975
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

591019:SHELL RS05985
gene id: 591019:SHELL_RS05985
uniprot id: D7D985
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

591019:SHELL RS07620
gene id: 591019:SHELL_RS07620
uniprot id: D7DA40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

591019:SHELL RS03150
gene id: 591019:SHELL_RS03150
uniprot id: D7DC65
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

591019:SHELL RS06990
gene id: 591019:SHELL_RS06990
uniprot id: D7D9R5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS05330
gene id: 591019:SHELL_RS05330
uniprot id: D7D8V6
names: Similarity
messages: Belongs to the peptidase U62 family.

591019:SHELL RS02580
gene id: 591019:SHELL_RS02580
uniprot id: D7DBV1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

591019:SHELL RS05895
gene id: 591019:SHELL_RS05895
uniprot id: D7D968
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

591019:SHELL RS06970
gene id: 591019:SHELL_RS06970
uniprot id: D7D9R1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

591019:SHELL RS00375
gene id: 591019:SHELL_RS00375
uniprot id: D7DAM6
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

591019:SHELL RS02560
gene id: 591019:SHELL_RS02560
uniprot id: D7DBU7
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS02775
gene id: 591019:SHELL_RS02775
uniprot id: D7DBZ1
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

591019:SHELL RS05795
gene id: 591019:SHELL_RS05795
uniprot id: D7D949
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

591019:SHELL RS06815
gene id: 591019:SHELL_RS06815
uniprot id: D7D9N4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

591019:SHELL RS08225
gene id: 591019:SHELL_RS08225
uniprot id: D7DAF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS06345
gene id: 591019:SHELL_RS06345
uniprot id: D7D9F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

591019:SHELL RS04860
gene id: 591019:SHELL_RS04860
uniprot id: D7D8L0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

591019:SHELL RS02020
gene id: 591019:SHELL_RS02020
uniprot id: D7DBI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

591019:SHELL RS07360
gene id: 591019:SHELL_RS07360
uniprot id: D7D9Z0
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

591019:SHELL RS03230
gene id: 591019:SHELL_RS03230
uniprot id: D7DC80
names: Similarity
messages: Belongs to the UPF0111 family.

591019:SHELL RS01785
gene id: 591019:SHELL_RS01785
uniprot id: D7DBE4
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

591019:SHELL RS07030
gene id: 591019:SHELL_RS07030
uniprot id: D7D9S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

591019:SHELL RS03710
gene id: 591019:SHELL_RS03710
uniprot id: D7D7X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

591019:SHELL RS07770
gene id: 591019:SHELL_RS07770
uniprot id: D7DA70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

591019:SHELL RS02305
gene id: 591019:SHELL_RS02305
uniprot id: D7DBP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS02280
gene id: 591019:SHELL_RS02280
uniprot id: D7DBP0
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

591019:SHELL RS08235
gene id: 591019:SHELL_RS08235
uniprot id: D7DAF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS00735
gene id: 591019:SHELL_RS00735
uniprot id: D7DAU1
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

591019:SHELL RS06565
gene id: 591019:SHELL_RS06565
uniprot id: D7D9J2
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

591019:SHELL RS03605
gene id: 591019:SHELL_RS03605
uniprot id: D7DCF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS01560
gene id: 591019:SHELL_RS01560
uniprot id: D7DB97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS04155
gene id: 591019:SHELL_RS04155
uniprot id: D7D866
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS05080
gene id: 591019:SHELL_RS05080
uniprot id: D7D8Q4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

591019:SHELL RS03480
gene id: 591019:SHELL_RS03480
uniprot id: D7DCC9
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS01470
gene id: 591019:SHELL_RS01470
uniprot id: D7DB79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

591019:SHELL RS01425
gene id: 591019:SHELL_RS01425
uniprot id: D7DB70
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

591019:SHELL RS01195
gene id: 591019:SHELL_RS01195
uniprot id: D7DB26
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07585
gene id: 591019:SHELL_RS07585
uniprot id: D7DA33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

591019:SHELL RS04430
gene id: 591019:SHELL_RS04430
uniprot id: D7D8C1
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

591019:SHELL RS00510
gene id: 591019:SHELL_RS00510
uniprot id: D7DAQ0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

591019:SHELL RS01970
gene id: 591019:SHELL_RS01970
uniprot id: D7DBI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS00715
gene id: 591019:SHELL_RS00715
uniprot id: D7DAT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591019:SHELL RS07960
gene id: 591019:SHELL_RS07960
uniprot id: D7DAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

591019:SHELL RS05790
gene id: 591019:SHELL_RS05790
uniprot id: D7D948
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

591019:SHELL RS07230
gene id: 591019:SHELL_RS07230
uniprot id: D7D9W4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

591019:SHELL RS00690
gene id: 591019:SHELL_RS00690
uniprot id: D7DAT2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591019:SHELL RS03955
gene id: 591019:SHELL_RS03955
uniprot id: D7D823
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

591019:SHELL RS07705
gene id: 591019:SHELL_RS07705
uniprot id: D7DA58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

591019:SHELL RS08070
gene id: 591019:SHELL_RS08070
uniprot id: D7DAC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

591019:SHELL RS06305
gene id: 591019:SHELL_RS06305
uniprot id: D7D9E8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

591019:SHELL RS05255
gene id: 591019:SHELL_RS05255
uniprot id: D7D8U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

591019:SHELL RS07270
gene id: 591019:SHELL_RS07270
uniprot id: D7D9X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

591019:SHELL RS00075
gene id: 591019:SHELL_RS00075
uniprot id: D7DAG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

591019:SHELL RS06740
gene id: 591019:SHELL_RS06740
uniprot id: D7D9M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

591019:SHELL RS01530
gene id: 591019:SHELL_RS01530
uniprot id: D7DB91
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

591019:SHELL RS01545
gene id: 591019:SHELL_RS01545
uniprot id: D7DB94
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

591019:SHELL RS02090
gene id: 591019:SHELL_RS02090
uniprot id: D7DBK2
names: Similarity
messages: Belongs to the ZPR1 family.

591019:SHELL RS06765
gene id: 591019:SHELL_RS06765
uniprot id: D7D9M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

591019:SHELL RS03965
gene id: 591019:SHELL_RS03965
uniprot id: D7D825
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

591019:SHELL RS06935
gene id: 591019:SHELL_RS06935
uniprot id: D7D9Q5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

591019:SHELL RS03900
gene id: 591019:SHELL_RS03900
uniprot id: D7D811
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

591019:SHELL RS02955
gene id: 591019:SHELL_RS02955
uniprot id: D7DC27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

591019:SHELL RS00810
gene id: 591019:SHELL_RS00810
uniprot id: D7DAV7
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

591019:SHELL RS02880
gene id: 591019:SHELL_RS02880
uniprot id: D7DC10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

591019:SHELL RS05850
gene id: 591019:SHELL_RS05850
uniprot id: D7D960
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS08040
gene id: 591019:SHELL_RS08040
uniprot id: D7DAB7
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

591019:SHELL RS08125
gene id: 591019:SHELL_RS08125
uniprot id: D7DAD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS02940
gene id: 591019:SHELL_RS02940
uniprot id: D7DC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

591019:SHELL RS03290
gene id: 591019:SHELL_RS03290
uniprot id: D7DC92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS06840
gene id: 591019:SHELL_RS06840
uniprot id: D7D9N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

591019:SHELL RS06280
gene id: 591019:SHELL_RS06280
uniprot id: D7D9E3
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS05175
gene id: 591019:SHELL_RS05175
uniprot id: D7D8S4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

591019:SHELL RS06550
gene id: 591019:SHELL_RS06550
uniprot id: D7D9I9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

591019:SHELL RS04385
gene id: 591019:SHELL_RS04385
uniprot id: D7D8B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

591019:SHELL RS06175
gene id: 591019:SHELL_RS06175
uniprot id: D7D9C1
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

591019:SHELL RS03265
gene id: 591019:SHELL_RS03265
uniprot id: D7DC87
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

591019:SHELL RS06960
gene id: 591019:SHELL_RS06960
uniprot id: D7D9Q9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

591019:SHELL RS03510
gene id: 591019:SHELL_RS03510
uniprot id: D7DCD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS05665
gene id: 591019:SHELL_RS05665
uniprot id: D7D923
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

591019:SHELL RS00700
gene id: 591019:SHELL_RS00700
uniprot id: D7DAT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591019:SHELL RS02890
gene id: 591019:SHELL_RS02890
uniprot id: D7DC12
names: Similarity
messages: Belongs to the carbamate kinase family.

591019:SHELL RS08100
gene id: 591019:SHELL_RS08100
uniprot id: D7DAC9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

591019:SHELL RS06775
gene id: 591019:SHELL_RS06775
uniprot id: D7D9M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

591019:SHELL RS03500
gene id: 591019:SHELL_RS03500
uniprot id: D7DCD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS05900
gene id: 591019:SHELL_RS05900
uniprot id: D7D969
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

591019:SHELL RS07775
gene id: 591019:SHELL_RS07775
uniprot id: D7DA71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

591019:SHELL RS06800
gene id: 591019:SHELL_RS06800
uniprot id: D7D9N1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

591019:SHELL RS08220
gene id: 591019:SHELL_RS08220
uniprot id: D7DAF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

591019:SHELL RS05155
gene id: 591019:SHELL_RS05155
uniprot id: D7D8S0
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS01540
gene id: 591019:SHELL_RS01540
uniprot id: D7DB93
names: Similarity
messages: Belongs to the UPF0251 family.

591019:SHELL RS05845
gene id: 591019:SHELL_RS05845
uniprot id: D7D959
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

591019:SHELL RS05100
gene id: 591019:SHELL_RS05100
uniprot id: D7D8Q8
names: Similarity
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

591019:SHELL RS06755
gene id: 591019:SHELL_RS06755
uniprot id: D7D9M2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

591019:SHELL RS06005
gene id: 591019:SHELL_RS06005
uniprot id: D7D989
names: Function
messages: Part of a potassium transport system.

591019:SHELL RS04645
gene id: 591019:SHELL_RS04645
uniprot id: D7D8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

591019:SHELL RS05820
gene id: 591019:SHELL_RS05820
uniprot id: D7D954
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

591019:SHELL RS07910
gene id: 591019:SHELL_RS07910
uniprot id: D7DA96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

591019:SHELL RS03770
gene id: 591019:SHELL_RS03770
uniprot id: D7D7Y6
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

591019:SHELL RS02905
gene id: 591019:SHELL_RS02905
uniprot id: D7DC15
names: Similarity
messages: Belongs to the UPF0282 family.

591019:SHELL RS07000
gene id: 591019:SHELL_RS07000
uniprot id: D7D9R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

591019:SHELL RS03195
gene id: 591019:SHELL_RS03195
uniprot id: D7DC74
names: Similarity
messages: Belongs to the UPRTase family.

591019:SHELL RS06435
gene id: 591019:SHELL_RS06435
uniprot id: D7D9H0
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

591019:SHELL RS00860
gene id: 591019:SHELL_RS00860
uniprot id: D7DAW6
names: Similarity
messages: Belongs to the thymidylate kinase family.

591019:SHELL RS01720
gene id: 591019:SHELL_RS01720
uniprot id: D7DBD1
names: Similarity
messages: Belongs to the UPF0047 family.

591019:SHELL RS03110
gene id: 591019:SHELL_RS03110
uniprot id: D7DC57
names: Similarity
messages: Belongs to the glutaredoxin family.

591019:SHELL RS01665
gene id: 591019:SHELL_RS01665
uniprot id: D7DBC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

591019:SHELL RS05405
gene id: 591019:SHELL_RS05405
uniprot id: D7D8X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS00010
gene id: 591019:SHELL_RS00010
uniprot id: D7DAF7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

591019:SHELL RS08140
gene id: 591019:SHELL_RS08140
uniprot id: D7DAD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS03670
gene id: 591019:SHELL_RS03670
uniprot id: D7DCG6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

591019:SHELL RS03960
gene id: 591019:SHELL_RS03960
uniprot id: D7D824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

591019:SHELL RS06980
gene id: 591019:SHELL_RS06980
uniprot id: D7D9R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

591019:SHELL RS00885
gene id: 591019:SHELL_RS00885
uniprot id: D7DAX1
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

591019:SHELL RS08205
gene id: 591019:SHELL_RS08205
uniprot id: D7DAE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

591019:SHELL RS06760
gene id: 591019:SHELL_RS06760
uniprot id: D7D9M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

591019:SHELL RS05465
gene id: 591019:SHELL_RS05465
uniprot id: D7D8Y3
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

591019:SHELL RS06805
gene id: 591019:SHELL_RS06805
uniprot id: D7D9N2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

591019:SHELL RS05645
gene id: 591019:SHELL_RS05645
uniprot id: D7D919
names: Similarity
messages: Belongs to the phosphohexose mutase family.

591019:SHELL RS05250
gene id: 591019:SHELL_RS05250
uniprot id: D7D8T9
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

591019:SHELL RS07210
gene id: 591019:SHELL_RS07210
uniprot id: D7D9W1
names: Subcellular Location Annotation
messages: Nucleus

591019:SHELL RS07930
gene id: 591019:SHELL_RS07930
uniprot id: D7DAA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

591019:SHELL RS04855
gene id: 591019:SHELL_RS04855
uniprot id: D7D8K9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

591019:SHELL RS02555
gene id: 591019:SHELL_RS02555
uniprot id: D7DBU6
names: Similarity
messages: Belongs to the MoaB/Mog family.

591019:SHELL RS07015
gene id: 591019:SHELL_RS07015
uniprot id: D7D9S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

591019:SHELL RS01095
gene id: 591019:SHELL_RS01095
uniprot id: D7DB09
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

591019:SHELL RS06810
gene id: 591019:SHELL_RS06810
uniprot id: D7D9N3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

591019:SHELL RS07010
gene id: 591019:SHELL_RS07010
uniprot id: D7D9R9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

591019:SHELL RS00750
gene id: 591019:SHELL_RS00750
uniprot id: D7DAU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

591019:SHELL RS00535
gene id: 591019:SHELL_RS00535
uniprot id: D7DAQ6
names: Similarity
messages: Belongs to the peptidase C15 family.

591019:SHELL RS00850
gene id: 591019:SHELL_RS00850
uniprot id: D7DAW4
names: Similarity
messages: Belongs to the UPF0147 family.

591019:SHELL RS08155
gene id: 591019:SHELL_RS08155
uniprot id: D7DAE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

591019:SHELL RS01705
gene id: 591019:SHELL_RS01705
uniprot id: D7DBC8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

591019:SHELL RS02055
gene id: 591019:SHELL_RS02055
uniprot id: D7DBJ5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

591019:SHELL RS06495
gene id: 591019:SHELL_RS06495
uniprot id: D7D9H8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

591019:SHELL RS00770
gene id: 591019:SHELL_RS00770
uniprot id: D7DAU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

591019:SHELL RS07045
gene id: 591019:SHELL_RS07045
uniprot id: D7D9S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

591019:SHELL RS06535
gene id: 591019:SHELL_RS06535
uniprot id: D7D9I6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS00815
gene id: 591019:SHELL_RS00815
uniprot id: D7DAV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

591019:SHELL RS07650
gene id: 591019:SHELL_RS07650
uniprot id: D7DA46
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS07760
gene id: 591019:SHELL_RS07760
uniprot id: D7DA67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

591019:SHELL RS02350
gene id: 591019:SHELL_RS02350
uniprot id: D7DBQ4
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07095
gene id: 591019:SHELL_RS07095
uniprot id: D7D9T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

591019:SHELL RS04010
gene id: 591019:SHELL_RS04010
uniprot id: D7D835
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

591019:SHELL RS00120
gene id: 591019:SHELL_RS00120
uniprot id: D7DAH7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

591019:SHELL RS07950
gene id: 591019:SHELL_RS07950
uniprot id: D7DAA4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

591019:SHELL RS03095
gene id: 591019:SHELL_RS03095
uniprot id: D7DC54
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

591019:SHELL RS03635
gene id: 591019:SHELL_RS03635
uniprot id: D7DCF9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

591019:SHELL RS02595
gene id: 591019:SHELL_RS02595
uniprot id: D7DBV4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

591019:SHELL RS00500
gene id: 591019:SHELL_RS00500
uniprot id: D7DAP9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

591019:SHELL RS03045
gene id: 591019:SHELL_RS03045
uniprot id: D7DC44
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

591019:SHELL RS05705
gene id: 591019:SHELL_RS05705
uniprot id: D7D931
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

591019:SHELL RS05185
gene id: 591019:SHELL_RS05185
uniprot id: D7D8S6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

591019:SHELL RS07285
gene id: 591019:SHELL_RS07285
uniprot id: D7D9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS08150
gene id: 591019:SHELL_RS08150
uniprot id: D7DAD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

591019:SHELL RS07065
gene id: 591019:SHELL_RS07065
uniprot id: D7D9T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS05275
gene id: 591019:SHELL_RS05275
uniprot id: D7D8U4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

591019:SHELL RS02960
gene id: 591019:SHELL_RS02960
uniprot id: D7DC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

591019:SHELL RS08160
gene id: 591019:SHELL_RS08160
uniprot id: D7DAE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS00105
gene id: 591019:SHELL_RS00105
uniprot id: D7DAH4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS04005
gene id: 591019:SHELL_RS04005
uniprot id: D7D834
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

591019:SHELL RS08085
gene id: 591019:SHELL_RS08085
uniprot id: D7DAC6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

591019:SHELL RS03735
gene id: 591019:SHELL_RS03735
uniprot id: D7D7X9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

591019:SHELL RS00055
gene id: 591019:SHELL_RS00055
uniprot id: D7DAG4
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

591019:SHELL RS01580
gene id: 591019:SHELL_RS01580
uniprot id: D7DBA1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

591019:SHELL RS03285
gene id: 591019:SHELL_RS03285
uniprot id: D7DC91
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS01380
gene id: 591019:SHELL_RS01380
uniprot id: D7DB61
names: Similarity
messages: Belongs to the UPF0235 family.

591019:SHELL RS00085
gene id: 591019:SHELL_RS00085
uniprot id: D7DAH0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

591019:SHELL RS08135
gene id: 591019:SHELL_RS08135
uniprot id: D7DAD6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

591019:SHELL RS00550
gene id: 591019:SHELL_RS00550
uniprot id: D7DAQ7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

591019:SHELL RS06715
gene id: 591019:SHELL_RS06715
uniprot id: D7D9L5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

591019:SHELL RS07480
gene id: 591019:SHELL_RS07480
uniprot id: D7DA14
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

591019:SHELL RS04920
gene id: 591019:SHELL_RS04920
uniprot id: D7D8M1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS08250
gene id: 591019:SHELL_RS08250
uniprot id: D7DAF6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

591019:SHELL RS05190
gene id: 591019:SHELL_RS05190
uniprot id: D7D8S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

591019:SHELL RS02110
gene id: 591019:SHELL_RS02110
uniprot id: D7DBK6
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

591019:SHELL RS01120
gene id: 591019:SHELL_RS01120
uniprot id: D7DB14
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS07175
gene id: 591019:SHELL_RS07175
uniprot id: D7D9V4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

591019:SHELL RS07555
gene id: 591019:SHELL_RS07555
uniprot id: D7DA28
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

591019:SHELL RS07005
gene id: 591019:SHELL_RS07005
uniprot id: D7D9R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS01830
gene id: 591019:SHELL_RS01830
uniprot id: D7DBF3
names: Similarity
messages: Belongs to the BtpA family.

591019:SHELL RS05210
gene id: 591019:SHELL_RS05210
uniprot id: D7D8T1
names: Similarity
messages: Belongs to the Nth/MutY family.

591019:SHELL RS07860
gene id: 591019:SHELL_RS07860
uniprot id: D7DA88
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

591019:SHELL RS01855
gene id: 591019:SHELL_RS01855
uniprot id: D7DBF8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS05295
gene id: 591019:SHELL_RS05295
uniprot id: D7D8U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

591019:SHELL RS06630
gene id: 591019:SHELL_RS06630
uniprot id: D7D9K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS08215
gene id: 591019:SHELL_RS08215
uniprot id: D7DAF1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

591019:SHELL RS02665
gene id: 591019:SHELL_RS02665
uniprot id: D7DBW8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

591019:SHELL RS06180
gene id: 591019:SHELL_RS06180
uniprot id: D7D9C2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

591019:SHELL RS06995
gene id: 591019:SHELL_RS06995
uniprot id: D7D9R6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

591019:SHELL RS05735
gene id: 591019:SHELL_RS05735
uniprot id: D7D937
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

591019:SHELL RS03995
gene id: 591019:SHELL_RS03995
uniprot id: D7D832
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

591019:SHELL RS05400
gene id: 591019:SHELL_RS05400
uniprot id: D7D8X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS07515
gene id: 591019:SHELL_RS07515
uniprot id: D7DA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

591019:SHELL RS07700
gene id: 591019:SHELL_RS07700
uniprot id: D7DA57
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

591019:SHELL RS07195
gene id: 591019:SHELL_RS07195
uniprot id: D7D9V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

591019:SHELL RS03805
gene id: 591019:SHELL_RS03805
uniprot id: D7D7Z3
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

591019:SHELL RS01210
gene id: 591019:SHELL_RS01210
uniprot id: D7DB27
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

591019:SHELL RS07540
gene id: 591019:SHELL_RS07540
uniprot id: D7DA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

591019:SHELL RS03350
gene id: 591019:SHELL_RS03350
uniprot id: D7DCA4
names: Similarity
messages: Belongs to the peptidase M20A family.

591019:SHELL RS05825
gene id: 591019:SHELL_RS05825
uniprot id: D7D955
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

591019:SHELL RS05875
gene id: 591019:SHELL_RS05875
uniprot id: D7D964
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS05620
gene id: 591019:SHELL_RS05620
uniprot id: D7D914
names: Similarity
messages: Belongs to the RuvB family.

591019:SHELL RS05810
gene id: 591019:SHELL_RS05810
uniprot id: D7D952
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

591019:SHELL RS05455
gene id: 591019:SHELL_RS05455
uniprot id: D7D8Y1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

591019:SHELL RS07635
gene id: 591019:SHELL_RS07635
uniprot id: D7DA43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

591019:SHELL RS02185
gene id: 591019:SHELL_RS02185
uniprot id: D7DBM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

591019:SHELL RS06635
gene id: 591019:SHELL_RS06635
uniprot id: D7D9K2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

591019:SHELL RS07305
gene id: 591019:SHELL_RS07305
uniprot id: D7D9X9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS06275
gene id: 591019:SHELL_RS06275
uniprot id: D7D9E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

591019:SHELL RS03180
gene id: 591019:SHELL_RS03180
uniprot id: D7DC71
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

591019:SHELL RS05835
gene id: 591019:SHELL_RS05835
uniprot id: D7D957
names: Similarity
messages: Belongs to the TFIIB family.

591019:SHELL RS03170
gene id: 591019:SHELL_RS03170
uniprot id: D7DC69
names: Similarity
messages: Belongs to the glutamine synthetase family.

591019:SHELL RS08030
gene id: 591019:SHELL_RS08030
uniprot id: D7DAB5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS05585
gene id: 591019:SHELL_RS05585
uniprot id: D7D907
names: Caution
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS00220
gene id: 591019:SHELL_RS00220
uniprot id: D7DAJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

591019:SHELL RS06225
gene id: 591019:SHELL_RS06225
uniprot id: D7D9D1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS01790
gene id: 591019:SHELL_RS01790
uniprot id: D7DBE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

591019:SHELL RS05975
gene id: 591019:SHELL_RS05975
uniprot id: D7D983
names: Subcellular Location Annotation
messages: Nucleus

591019:SHELL RS03620
gene id: 591019:SHELL_RS03620
uniprot id: D7DCF6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

591019:SHELL RS03950
gene id: 591019:SHELL_RS03950
uniprot id: D7D821
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

591019:SHELL RS01695
gene id: 591019:SHELL_RS01695
uniprot id: D7DBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

591019:SHELL RS01235
gene id: 591019:SHELL_RS01235
uniprot id: D7DB32
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

591019:SHELL RS01085
gene id: 591019:SHELL_RS01085
uniprot id: D7DB07
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS08095
gene id: 591019:SHELL_RS08095
uniprot id: D7DAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

591019:SHELL RS04830
gene id: 591019:SHELL_RS04830
uniprot id: D7D8K4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

591019:SHELL RS02935
gene id: 591019:SHELL_RS02935
uniprot id: D7DC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

591019:SHELL RS08145
gene id: 591019:SHELL_RS08145
uniprot id: D7DAD8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

591019:SHELL RS02860
gene id: 591019:SHELL_RS02860
uniprot id: D7DC06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

591019:SHELL RS06085
gene id: 591019:SHELL_RS06085
uniprot id: D7D9A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS07040
gene id: 591019:SHELL_RS07040
uniprot id: D7D9S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS06770
gene id: 591019:SHELL_RS06770
uniprot id: D7D9M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

591019:SHELL RS02370
gene id: 591019:SHELL_RS02370
uniprot id: D7DBQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

591019:SHELL RS00160
gene id: 591019:SHELL_RS00160
uniprot id: D7DAI4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

591019:SHELL RS03595
gene id: 591019:SHELL_RS03595
uniprot id: D7DCF1
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07160
gene id: 591019:SHELL_RS07160
uniprot id: D7D9V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

591019:SHELL RS03025
gene id: 591019:SHELL_RS03025
uniprot id: D7DC40
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS08065
gene id: 591019:SHELL_RS08065
uniprot id: D7DAC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

591019:SHELL RS07205
gene id: 591019:SHELL_RS07205
uniprot id: D7D9W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

591019:SHELL RS06300
gene id: 591019:SHELL_RS06300
uniprot id: D7D9E7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

591019:SHELL RS07110
gene id: 591019:SHELL_RS07110
uniprot id: D7D9T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

591019:SHELL RS00795
gene id: 591019:SHELL_RS00795
uniprot id: D7DAV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

591019:SHELL RS07520
gene id: 591019:SHELL_RS07520
uniprot id: D7DA22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS08130
gene id: 591019:SHELL_RS08130
uniprot id: D7DAD5
names: Similarity
messages: Belongs to the MEMO1 family.

591019:SHELL RS07105
gene id: 591019:SHELL_RS07105
uniprot id: D7D9T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS07945
gene id: 591019:SHELL_RS07945
uniprot id: D7DAA3
names: Similarity
messages: Belongs to the SDO1/SBDS family.

591019:SHELL RS00125
gene id: 591019:SHELL_RS00125
uniprot id: D7DAH8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

591019:SHELL RS06785
gene id: 591019:SHELL_RS06785
uniprot id: D7D9M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

591019:SHELL RS00845
gene id: 591019:SHELL_RS00845
uniprot id: D7DAW3
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

591019:SHELL RS01575
gene id: 591019:SHELL_RS01575
uniprot id: D7DBA0
names: Similarity
messages: Belongs to the DMRL synthase family.

591019:SHELL RS06555
gene id: 591019:SHELL_RS06555
uniprot id: D7D9J0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

591019:SHELL RS05180
gene id: 591019:SHELL_RS05180
uniprot id: D7D8S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

591019:SHELL RS00290
gene id: 591019:SHELL_RS00290
uniprot id: D7DAK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

591019:SHELL RS08170
gene id: 591019:SHELL_RS08170
uniprot id: D7DAE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

591019:SHELL RS07625
gene id: 591019:SHELL_RS07625
uniprot id: D7DA41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

591019:SHELL RS03465
gene id: 591019:SHELL_RS03465
uniprot id: D7DCC6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

591019:SHELL RS07610
gene id: 591019:SHELL_RS07610
uniprot id: D7DA38
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

591019:SHELL RS05240
gene id: 591019:SHELL_RS05240
uniprot id: D7D8T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

591019:SHELL RS03445
gene id: 591019:SHELL_RS03445
uniprot id: D7DCC2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

591019:SHELL RS02265
gene id: 591019:SHELL_RS02265
uniprot id: D7DBN7
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS04885
gene id: 591019:SHELL_RS04885
uniprot id: D7D8L5
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

591019:SHELL RS00095
gene id: 591019:SHELL_RS00095
uniprot id: D7DAH2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

591019:SHELL RS05980
gene id: 591019:SHELL_RS05980
uniprot id: D7D984
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

591019:SHELL RS03935
gene id: 591019:SHELL_RS03935
uniprot id: D7D818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591019:SHELL RS05500
gene id: 591019:SHELL_RS05500
uniprot id: D7D8Y9
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS07280
gene id: 591019:SHELL_RS07280
uniprot id: D7D9X4
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS05525
gene id: 591019:SHELL_RS05525
uniprot id: D7D8Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

591019:SHELL RS07715
gene id: 591019:SHELL_RS07715
uniprot id: D7DA59
names: Similarity
messages: Belongs to the pyruvate kinase family.

591019:SHELL RS07365
gene id: 591019:SHELL_RS07365
uniprot id: D7D9Z1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

591019:SHELL RS03455
gene id: 591019:SHELL_RS03455
uniprot id: D7DCC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

591019:SHELL RS07020
gene id: 591019:SHELL_RS07020
uniprot id: D7D9S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

591019:SHELL RS04055
gene id: 591019:SHELL_RS04055
uniprot id: D7D844
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

591019:SHELL RS06930
gene id: 591019:SHELL_RS06930
uniprot id: D7D9Q4
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

591019:SHELL RS06790
gene id: 591019:SHELL_RS06790
uniprot id: D7D9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

591019:SHELL RS05125
gene id: 591019:SHELL_RS05125
uniprot id: D7D8R3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

591019:SHELL RS03245
gene id: 591019:SHELL_RS03245
uniprot id: D7DC83
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

591019:SHELL RS07680
gene id: 591019:SHELL_RS07680
uniprot id: D7DA52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

591019:SHELL RS08105
gene id: 591019:SHELL_RS08105
uniprot id: D7DAD0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

591019:SHELL RS07785
gene id: 591019:SHELL_RS07785
uniprot id: D7DA73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

591019:SHELL RS00360
gene id: 591019:SHELL_RS00360
uniprot id: D7DAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

591019:SHELL RS08090
gene id: 591019:SHELL_RS08090
uniprot id: D7DAC7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

591019:SHELL RS01850
gene id: 591019:SHELL_RS01850
uniprot id: D7DBF7
names: Similarity
messages: Belongs to the peptidase S8 family.

591019:SHELL RS08055
gene id: 591019:SHELL_RS08055
uniprot id: D7DAC0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

591019:SHELL RS04850
gene id: 591019:SHELL_RS04850
uniprot id: D7D8K8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

591019:SHELL RS03730
gene id: 591019:SHELL_RS03730
uniprot id: D7D7X8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

591019:SHELL RS05935
gene id: 591019:SHELL_RS05935
uniprot id: D7D976
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591019:SHELL RS07815
gene id: 591019:SHELL_RS07815
uniprot id: D7DA79
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS00170
gene id: 591019:SHELL_RS00170
uniprot id: D7DAI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

591019:SHELL RS00775
gene id: 591019:SHELL_RS00775
uniprot id: D7DAU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

591019:SHELL RS00335
gene id: 591019:SHELL_RS00335
uniprot id: D7DAL8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

591019:SHELL RS06580
gene id: 591019:SHELL_RS06580
uniprot id: D7D9J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

591019:SHELL RS06965
gene id: 591019:SHELL_RS06965
uniprot id: D7D9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

591019:SHELL RS00380
gene id: 591019:SHELL_RS00380
uniprot id: D7DAM7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

591019:SHELL RS06985
gene id: 591019:SHELL_RS06985
uniprot id: D7D9R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

591019:SHELL RS06690
gene id: 591019:SHELL_RS06690
uniprot id: D7D9L0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

591019:SHELL RS02865
gene id: 591019:SHELL_RS02865
uniprot id: D7DC07
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591019:SHELL RS00910
gene id: 591019:SHELL_RS00910
uniprot id: D7DAX6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

591019:SHELL RS04745
gene id: 591019:SHELL_RS04745
uniprot id: D7D8I7
names: Subcellular Location Annotation
messages: Membrane

591019:SHELL RS03940
gene id: 591019:SHELL_RS03940
uniprot id: D7D819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

591019:SHELL RS01990
gene id: 591019:SHELL_RS01990
uniprot id: D7DBI2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

591019:SHELL RS07075
gene id: 591019:SHELL_RS07075
uniprot id: D7D9T2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.