591001:ACFER RS06480
gene id: 591001:ACFER_RS06480
uniprot id: D2RKN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

591001:ACFER RS02555
gene id: 591001:ACFER_RS02555
uniprot id: D2RII5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS02450
gene id: 591001:ACFER_RS02450
uniprot id: D2RIG4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

591001:ACFER RS08390
gene id: 591001:ACFER_RS08390
uniprot id: D2RLQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

591001:ACFER RS05240
gene id: 591001:ACFER_RS05240
uniprot id: D2RJX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

591001:ACFER RS00635
gene id: 591001:ACFER_RS00635
uniprot id: D2RNA1
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS05065
gene id: 591001:ACFER_RS05065
uniprot id: D2RJU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

591001:ACFER RS11110
gene id: 591001:ACFER_RS11110
uniprot id: D2RKD4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

591001:ACFER RS01270
gene id: 591001:ACFER_RS01270
uniprot id: D2RNM2
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06305
gene id: 591001:ACFER_RS06305
uniprot id: D2RKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

591001:ACFER RS08095
gene id: 591001:ACFER_RS08095
uniprot id: D2RLJ4
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

591001:ACFER RS08060
gene id: 591001:ACFER_RS08060
uniprot id: D2RLI7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07355
gene id: 591001:ACFER_RS07355
uniprot id: D2RL52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

591001:ACFER RS00990
gene id: 591001:ACFER_RS00990
uniprot id: D2RNG9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

591001:ACFER RS09760
gene id: 591001:ACFER_RS09760
uniprot id: D2RMF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

591001:ACFER RS09285
gene id: 591001:ACFER_RS09285
uniprot id: P11570
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the HgdC. Reversibly inactivated by oxidants such as 2-nitrophenol, 3-nitrophenol, 4-nitrophenol, 4-nitrobenzoate, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) and chloramphenicol. Irreversibly inactivated by oxidants such as hydroxylamine and nitrite.
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
messages: Binds 1 FMN per heterodimer.
messages: Binds 1 [4Fe-4S] cluster per heterodimer.
messages: Cytoplasm
messages: Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway (PubMed:3691501). Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)-glutaconyl-CoA (PubMed:3691501, PubMed:7398622, PubMed:7607244). The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical (PubMed:7607244). Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate (PubMed:7607244). The appropriate redox state of dehydratase HgdA-HgdB complex (CompD) is maintained by HgdC (CompA) via hydrolysis of ATP and ATP-dependent electron transfer (PubMed:7607244). Since the electron is recycled, the dehydratase is able to perform several turnovers with only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) (PubMed:7607244).
messages: The (R)-2-hydroxyglutaryl-CoA dehydratase enzyme system is a heterodimer composed of an alpha subunit (HgdA) and a beta subunit (HgdB).

591001:ACFER RS09095
gene id: 591001:ACFER_RS09095
uniprot id: D2RM32
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

591001:ACFER RS10380
gene id: 591001:ACFER_RS10380
uniprot id: D2RMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS04705
gene id: 591001:ACFER_RS04705
uniprot id: D2RJM9
names: Similarity
messages: Belongs to the UPF0297 family.

591001:ACFER RS01655
gene id: 591001:ACFER_RS01655
uniprot id: D2RNU4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

591001:ACFER RS05220
gene id: 591001:ACFER_RS05220
uniprot id: D2RJX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

591001:ACFER RS06370
gene id: 591001:ACFER_RS06370
uniprot id: D2RKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

591001:ACFER RS05490
gene id: 591001:ACFER_RS05490
uniprot id: D2RK33
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08225
gene id: 591001:ACFER_RS08225
uniprot id: D2RLM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

591001:ACFER RS01595
gene id: 591001:ACFER_RS01595
uniprot id: D2RNT2
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

591001:ACFER RS00290
gene id: 591001:ACFER_RS00290
uniprot id: D2RN32
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

591001:ACFER RS02230
gene id: 591001:ACFER_RS02230
uniprot id: D2RP49
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

591001:ACFER RS01380
gene id: 591001:ACFER_RS01380
uniprot id: D2RNN9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

591001:ACFER RS10140
gene id: 591001:ACFER_RS10140
uniprot id: D2RMM8
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06025
gene id: 591001:ACFER_RS06025
uniprot id: D2RKD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS06250
gene id: 591001:ACFER_RS06250
uniprot id: D2RKI4
names: Similarity
messages: Belongs to the DHPS family.

591001:ACFER RS00465
gene id: 591001:ACFER_RS00465
uniprot id: D2RN67
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS06280
gene id: 591001:ACFER_RS06280
uniprot id: D2RKJ0
names: Similarity
messages: Belongs to the UPF0173 family.

591001:ACFER RS02570
gene id: 591001:ACFER_RS02570
uniprot id: D2RII8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

591001:ACFER RS08355
gene id: 591001:ACFER_RS08355
uniprot id: D2RLP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS06605
gene id: 591001:ACFER_RS06605
uniprot id: D2RKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

591001:ACFER RS02070
gene id: 591001:ACFER_RS02070
uniprot id: D2RP17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS08940
gene id: 591001:ACFER_RS08940
uniprot id: D2RM06
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS00775
gene id: 591001:ACFER_RS00775
uniprot id: D2RNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

591001:ACFER RS03260
gene id: 591001:ACFER_RS03260
uniprot id: D2RIW3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

591001:ACFER RS07215
gene id: 591001:ACFER_RS07215
uniprot id: D2RL24
names: Similarity
messages: Belongs to the LOR family.

591001:ACFER RS00325
gene id: 591001:ACFER_RS00325
uniprot id: D2RN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

591001:ACFER RS08990
gene id: 591001:ACFER_RS08990
uniprot id: D2RM16
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

591001:ACFER RS05305
gene id: 591001:ACFER_RS05305
uniprot id: D2RJZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

591001:ACFER RS09900
gene id: 591001:ACFER_RS09900
uniprot id: D2RMI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

591001:ACFER RS07750
gene id: 591001:ACFER_RS07750
uniprot id: D2RLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

591001:ACFER RS10350
gene id: 591001:ACFER_RS10350
uniprot id: D2RMR6
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

591001:ACFER RS06175
gene id: 591001:ACFER_RS06175
uniprot id: D2RKG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS09765
gene id: 591001:ACFER_RS09765
uniprot id: D2RMF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

591001:ACFER RS04540
gene id: 591001:ACFER_RS04540
uniprot id: D2RJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

591001:ACFER RS10040
gene id: 591001:ACFER_RS10040
uniprot id: D2RML0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

591001:ACFER RS03640
gene id: 591001:ACFER_RS03640
uniprot id: D2RJ33
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

591001:ACFER RS06095
gene id: 591001:ACFER_RS06095
uniprot id: D2RKF3
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

591001:ACFER RS09785
gene id: 591001:ACFER_RS09785
uniprot id: D2RMG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

591001:ACFER RS01805
gene id: 591001:ACFER_RS01805
uniprot id: D2RNX1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

591001:ACFER RS00630
gene id: 591001:ACFER_RS00630
uniprot id: D2RNA0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07760
gene id: 591001:ACFER_RS07760
uniprot id: D2RLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

591001:ACFER RS07500
gene id: 591001:ACFER_RS07500
uniprot id: D2RL80
names: Similarity
messages: Belongs to the peptidase M18 family.

591001:ACFER RS06870
gene id: 591001:ACFER_RS06870
uniprot id: D2RKV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

591001:ACFER RS06990
gene id: 591001:ACFER_RS06990
uniprot id: D2RKY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

591001:ACFER RS04080
gene id: 591001:ACFER_RS04080
uniprot id: D2RJB2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

591001:ACFER RS04585
gene id: 591001:ACFER_RS04585
uniprot id: D2RJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

591001:ACFER RS06600
gene id: 591001:ACFER_RS06600
uniprot id: D2RKQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

591001:ACFER RS04290
gene id: 591001:ACFER_RS04290
uniprot id: D2RJF2
names: Similarity
messages: Belongs to the thioredoxin family.

591001:ACFER RS01865
gene id: 591001:ACFER_RS01865
uniprot id: D2RNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

591001:ACFER RS04785
gene id: 591001:ACFER_RS04785
uniprot id: D2RJP5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS03850
gene id: 591001:ACFER_RS03850
uniprot id: D2RJ70
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

591001:ACFER RS04835
gene id: 591001:ACFER_RS04835
uniprot id: D2RJQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

591001:ACFER RS02585
gene id: 591001:ACFER_RS02585
uniprot id: D2RIJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591001:ACFER RS07025
gene id: 591001:ACFER_RS07025
uniprot id: D2RKY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

591001:ACFER RS00715
gene id: 591001:ACFER_RS00715
uniprot id: D2RNB5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

591001:ACFER RS03255
gene id: 591001:ACFER_RS03255
uniprot id: D2RIW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

591001:ACFER RS07955
gene id: 591001:ACFER_RS07955
uniprot id: D2RLG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

591001:ACFER RS04070
gene id: 591001:ACFER_RS04070
uniprot id: D2RJB0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS01600
gene id: 591001:ACFER_RS01600
uniprot id: D2RNT3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

591001:ACFER RS10400
gene id: 591001:ACFER_RS10400
uniprot id: D2RMS5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS06350
gene id: 591001:ACFER_RS06350
uniprot id: D2RKK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

591001:ACFER RS05995
gene id: 591001:ACFER_RS05995
uniprot id: D2RKD3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

591001:ACFER RS02200
gene id: 591001:ACFER_RS02200
uniprot id: D2RP43
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

591001:ACFER RS02440
gene id: 591001:ACFER_RS02440
uniprot id: D2RIG2
names: Similarity
messages: Belongs to the transketolase family.

591001:ACFER RS07320
gene id: 591001:ACFER_RS07320
uniprot id: D2RL45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS08120
gene id: 591001:ACFER_RS08120
uniprot id: D2RLJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

591001:ACFER RS08245
gene id: 591001:ACFER_RS08245
uniprot id: D2RLM4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02755
gene id: 591001:ACFER_RS02755
uniprot id: D2RIM4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09605
gene id: 591001:ACFER_RS09605
uniprot id: D2RMC6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS01715
gene id: 591001:ACFER_RS01715
uniprot id: D2RNV6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS09005
gene id: 591001:ACFER_RS09005
uniprot id: D2RM19
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS03120
gene id: 591001:ACFER_RS03120
uniprot id: D2RIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

591001:ACFER RS10695
gene id: 591001:ACFER_RS10695
uniprot id: D2RN16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS01045
gene id: 591001:ACFER_RS01045
uniprot id: D2RNI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

591001:ACFER RS10070
gene id: 591001:ACFER_RS10070
uniprot id: D2RML6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS08340
gene id: 591001:ACFER_RS08340
uniprot id: D2RLP3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS03950
gene id: 591001:ACFER_RS03950
uniprot id: D2RJ87
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08395
gene id: 591001:ACFER_RS08395
uniprot id: D2RLQ4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS04050
gene id: 591001:ACFER_RS04050
uniprot id: D2RJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

591001:ACFER RS03315
gene id: 591001:ACFER_RS03315
uniprot id: D2RIX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

591001:ACFER RS10135
gene id: 591001:ACFER_RS10135
uniprot id: D2RMM7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS10020
gene id: 591001:ACFER_RS10020
uniprot id: D2RMK7
names: Similarity
messages: Belongs to the CapA family.

591001:ACFER RS00780
gene id: 591001:ACFER_RS00780
uniprot id: D2RNC8
names: Similarity
messages: Belongs to the CvfB family.

591001:ACFER RS09775
gene id: 591001:ACFER_RS09775
uniprot id: D2RMF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS09890
gene id: 591001:ACFER_RS09890
uniprot id: D2RMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

591001:ACFER RS02460
gene id: 591001:ACFER_RS02460
uniprot id: D2RIG6
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

591001:ACFER RS09355
gene id: 591001:ACFER_RS09355
uniprot id: D2RM80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS02205
gene id: 591001:ACFER_RS02205
uniprot id: D2RP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

591001:ACFER RS07670
gene id: 591001:ACFER_RS07670
uniprot id: D2RLB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

591001:ACFER RS05370
gene id: 591001:ACFER_RS05370
uniprot id: D2RK06
names: Similarity
messages: Belongs to the peptidase M18 family.

591001:ACFER RS04155
gene id: 591001:ACFER_RS04155
uniprot id: D2RJC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS11870
gene id: 591001:ACFER_RS11870
uniprot id: D2RLU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

591001:ACFER RS09235
gene id: 591001:ACFER_RS09235
uniprot id: D2RM56
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

591001:ACFER RS04810
gene id: 591001:ACFER_RS04810
uniprot id: D2RJQ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

591001:ACFER RS02310
gene id: 591001:ACFER_RS02310
uniprot id: D2RID9
names: Similarity
messages: Belongs to the universal stress protein A family.

591001:ACFER RS10465
gene id: 591001:ACFER_RS10465
uniprot id: D2RMX2
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02980
gene id: 591001:ACFER_RS02980
uniprot id: D2RIR2
names: Similarity
messages: Belongs to the CpsD/CapB family.

591001:ACFER RS01295
gene id: 591001:ACFER_RS01295
uniprot id: D2RNM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS04455
gene id: 591001:ACFER_RS04455
uniprot id: D2RJI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

591001:ACFER RS00965
gene id: 591001:ACFER_RS00965
uniprot id: D2RNG4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06625
gene id: 591001:ACFER_RS06625
uniprot id: D2RKQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

591001:ACFER RS04620
gene id: 591001:ACFER_RS04620
uniprot id: D2RJL7
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09925
gene id: 591001:ACFER_RS09925
uniprot id: D2RMI8
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

591001:ACFER RS03975
gene id: 591001:ACFER_RS03975
uniprot id: D2RJ91
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

591001:ACFER RS09940
gene id: 591001:ACFER_RS09940
uniprot id: D2RMJ1
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

591001:ACFER RS00350
gene id: 591001:ACFER_RS00350
uniprot id: D2RN44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

591001:ACFER RS03985
gene id: 591001:ACFER_RS03985
uniprot id: D2RJ93
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

591001:ACFER RS00210
gene id: 591001:ACFER_RS00210
uniprot id: D2RN19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS08655
gene id: 591001:ACFER_RS08655
uniprot id: D2RLV1
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09835
gene id: 591001:ACFER_RS09835
uniprot id: D2RMH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

591001:ACFER RS04850
gene id: 591001:ACFER_RS04850
uniprot id: D2RJQ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS05990
gene id: 591001:ACFER_RS05990
uniprot id: D2RKD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

591001:ACFER RS00660
gene id: 591001:ACFER_RS00660
uniprot id: D2RNA6
names: Similarity
messages: Belongs to the UPF0166 family.

591001:ACFER RS02960
gene id: 591001:ACFER_RS02960
uniprot id: D2RIQ8
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09225
gene id: 591001:ACFER_RS09225
uniprot id: D2RM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

591001:ACFER RS06970
gene id: 591001:ACFER_RS06970
uniprot id: D2RKX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

591001:ACFER RS08585
gene id: 591001:ACFER_RS08585
uniprot id: D2RLT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

591001:ACFER RS06190
gene id: 591001:ACFER_RS06190
uniprot id: D2RKH1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

591001:ACFER RS02240
gene id: 591001:ACFER_RS02240
uniprot id: D2RP51
names: Similarity
messages: Belongs to the LacAB/RpiB family.

591001:ACFER RS02170
gene id: 591001:ACFER_RS02170
uniprot id: D2RP37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

591001:ACFER RS05180
gene id: 591001:ACFER_RS05180
uniprot id: D2RJW7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

591001:ACFER RS09470
gene id: 591001:ACFER_RS09470
uniprot id: D2RMA4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

591001:ACFER RS00945
gene id: 591001:ACFER_RS00945
uniprot id: D2RNG0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

591001:ACFER RS01625
gene id: 591001:ACFER_RS01625
uniprot id: D2RNT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

591001:ACFER RS04630
gene id: 591001:ACFER_RS04630
uniprot id: D2RJL9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

591001:ACFER RS03485
gene id: 591001:ACFER_RS03485
uniprot id: D2RJ08
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

591001:ACFER RS03215
gene id: 591001:ACFER_RS03215
uniprot id: D2RIV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

591001:ACFER RS08030
gene id: 591001:ACFER_RS08030
uniprot id: D2RLI1
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

591001:ACFER RS06380
gene id: 591001:ACFER_RS06380
uniprot id: D2RKL0
names: Similarity
messages: Belongs to the DprA/Smf family.

591001:ACFER RS06530
gene id: 591001:ACFER_RS06530
uniprot id: D2RKP0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

591001:ACFER RS09310
gene id: 591001:ACFER_RS09310
uniprot id: Q59111
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.
messages: Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
messages: Cytoplasm
messages: Heterooctamer of four A and four B subunits.

591001:ACFER RS09555
gene id: 591001:ACFER_RS09555
uniprot id: D2RMB6
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

591001:ACFER RS04465
gene id: 591001:ACFER_RS04465
uniprot id: D2RJI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

591001:ACFER RS01575
gene id: 591001:ACFER_RS01575
uniprot id: D2RNS8
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03765
gene id: 591001:ACFER_RS03765
uniprot id: D2RJ58
names: Similarity
messages: Belongs to the ycf81 family.

591001:ACFER RS09110
gene id: 591001:ACFER_RS09110
uniprot id: D2RM34
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

591001:ACFER RS05005
gene id: 591001:ACFER_RS05005
uniprot id: D2RJT5
names: Similarity
messages: Belongs to the polypeptide deformylase family.

591001:ACFER RS01175
gene id: 591001:ACFER_RS01175
uniprot id: D2RNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

591001:ACFER RS07555
gene id: 591001:ACFER_RS07555
uniprot id: D2RL92
names: Similarity
messages: Belongs to the SAICAR synthetase family.

591001:ACFER RS01390
gene id: 591001:ACFER_RS01390
uniprot id: D2RNP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

591001:ACFER RS05895
gene id: 591001:ACFER_RS05895
uniprot id: D2RKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell surface

591001:ACFER RS02520
gene id: 591001:ACFER_RS02520
uniprot id: D2RIH8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

591001:ACFER RS07085
gene id: 591001:ACFER_RS07085
uniprot id: D2RL01
names: Similarity
messages: Belongs to the fabD family.

591001:ACFER RS07650
gene id: 591001:ACFER_RS07650
uniprot id: D2RLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

591001:ACFER RS04800
gene id: 591001:ACFER_RS04800
uniprot id: D2RJP8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

591001:ACFER RS03445
gene id: 591001:ACFER_RS03445
uniprot id: D2RJ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

591001:ACFER RS00455
gene id: 591001:ACFER_RS00455
uniprot id: D2RN65
names: Similarity
messages: Belongs to the UxaA family.

591001:ACFER RS00995
gene id: 591001:ACFER_RS00995
uniprot id: D2RNH0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

591001:ACFER RS10475
gene id: 591001:ACFER_RS10475
uniprot id: D2RMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

591001:ACFER RS07305
gene id: 591001:ACFER_RS07305
uniprot id: D2RL42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

591001:ACFER RS01335
gene id: 591001:ACFER_RS01335
uniprot id: D2RNN5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

591001:ACFER RS09305
gene id: 591001:ACFER_RS09305
uniprot id: Q59112
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.
messages: Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
messages: Cytoplasm
messages: Heterooctamer of four A and four B subunits.

591001:ACFER RS04870
gene id: 591001:ACFER_RS04870
uniprot id: D2RJR2
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

591001:ACFER RS03530
gene id: 591001:ACFER_RS03530
uniprot id: D2RJ12
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

591001:ACFER RS08175
gene id: 591001:ACFER_RS08175
uniprot id: D2RLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

591001:ACFER RS09755
gene id: 591001:ACFER_RS09755
uniprot id: D2RMF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

591001:ACFER RS02260
gene id: 591001:ACFER_RS02260
uniprot id: D2RIC9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

591001:ACFER RS08440
gene id: 591001:ACFER_RS08440
uniprot id: D2RLR0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

591001:ACFER RS08760
gene id: 591001:ACFER_RS08760
uniprot id: D2RLX2
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09300
gene id: 591001:ACFER_RS09300
uniprot id: Q06700
names: Function
names: Subunit
messages: Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
messages: Heterooctamer consisting of two alpha, two beta, two gamma and two delta subunits.

591001:ACFER RS04845
gene id: 591001:ACFER_RS04845
uniprot id: D2RJQ7
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

591001:ACFER RS05060
gene id: 591001:ACFER_RS05060
uniprot id: D2RJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

591001:ACFER RS07365
gene id: 591001:ACFER_RS07365
uniprot id: D2RL54
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

591001:ACFER RS06520
gene id: 591001:ACFER_RS06520
uniprot id: D2RKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

591001:ACFER RS02830
gene id: 591001:ACFER_RS02830
uniprot id: D2RIN7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS05520
gene id: 591001:ACFER_RS05520
uniprot id: D2RK39
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS02445
gene id: 591001:ACFER_RS02445
uniprot id: D2RIG3
names: Similarity
messages: Belongs to the ThiD family.

591001:ACFER RS00230
gene id: 591001:ACFER_RS00230
uniprot id: D2RN23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

591001:ACFER RS05140
gene id: 591001:ACFER_RS05140
uniprot id: D2RJW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

591001:ACFER RS04485
gene id: 591001:ACFER_RS04485
uniprot id: D2RJJ1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

591001:ACFER RS03980
gene id: 591001:ACFER_RS03980
uniprot id: D2RJ92
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

591001:ACFER RS05375
gene id: 591001:ACFER_RS05375
uniprot id: D2RK07
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07735
gene id: 591001:ACFER_RS07735
uniprot id: D2RLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

591001:ACFER RS07135
gene id: 591001:ACFER_RS07135
uniprot id: D2RL11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

591001:ACFER RS10580
gene id: 591001:ACFER_RS10580
uniprot id: D2RMZ3
names: Similarity
messages: Belongs to the DapA family.

591001:ACFER RS03170
gene id: 591001:ACFER_RS03170
uniprot id: D2RIU9
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

591001:ACFER RS01895
gene id: 591001:ACFER_RS01895
uniprot id: D2RNY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

591001:ACFER RS07050
gene id: 591001:ACFER_RS07050
uniprot id: D2RKZ4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03780
gene id: 591001:ACFER_RS03780
uniprot id: D2RJ61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS03385
gene id: 591001:ACFER_RS03385
uniprot id: D2RIY8
names: Similarity
messages: Belongs to the UPF0246 family.

591001:ACFER RS00960
gene id: 591001:ACFER_RS00960
uniprot id: D2RNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

591001:ACFER RS06670
gene id: 591001:ACFER_RS06670
uniprot id: D2RKR8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

591001:ACFER RS02975
gene id: 591001:ACFER_RS02975
uniprot id: D2RIR1
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS04890
gene id: 591001:ACFER_RS04890
uniprot id: D2RJR6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

591001:ACFER RS06630
gene id: 591001:ACFER_RS06630
uniprot id: D2RKR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

591001:ACFER RS08110
gene id: 591001:ACFER_RS08110
uniprot id: D2RLJ7
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

591001:ACFER RS07625
gene id: 591001:ACFER_RS07625
uniprot id: D2RLA6
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

591001:ACFER RS02110
gene id: 591001:ACFER_RS02110
uniprot id: D2RP25
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

591001:ACFER RS01275
gene id: 591001:ACFER_RS01275
uniprot id: D2RNM3
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

591001:ACFER RS04710
gene id: 591001:ACFER_RS04710
uniprot id: D2RJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

591001:ACFER RS09295
gene id: 591001:ACFER_RS09295
uniprot id: P11568
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HgdC family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: HgdC (CompA) seems to require NADH to be functional.
messages: Homodimer.
messages: Inactivated by exposure to air within less than 15 minutes.
messages: Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional.

591001:ACFER RS08205
gene id: 591001:ACFER_RS08205
uniprot id: D2RLL6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS02430
gene id: 591001:ACFER_RS02430
uniprot id: D2RIG0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

591001:ACFER RS02115
gene id: 591001:ACFER_RS02115
uniprot id: D2RP26
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03740
gene id: 591001:ACFER_RS03740
uniprot id: D2RJ53
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

591001:ACFER RS04380
gene id: 591001:ACFER_RS04380
uniprot id: D2RJH0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

591001:ACFER RS10470
gene id: 591001:ACFER_RS10470
uniprot id: D2RMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

591001:ACFER RS10415
gene id: 591001:ACFER_RS10415
uniprot id: D2RMS8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

591001:ACFER RS05245
gene id: 591001:ACFER_RS05245
uniprot id: D2RJY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

591001:ACFER RS07390
gene id: 591001:ACFER_RS07390
uniprot id: D2RL59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07300
gene id: 591001:ACFER_RS07300
uniprot id: D2RL41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

591001:ACFER RS06210
gene id: 591001:ACFER_RS06210
uniprot id: D2RKH5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

591001:ACFER RS05345
gene id: 591001:ACFER_RS05345
uniprot id: D2RK01
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS08425
gene id: 591001:ACFER_RS08425
uniprot id: D2RLQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

591001:ACFER RS04715
gene id: 591001:ACFER_RS04715
uniprot id: D2RJN1
names: Similarity
messages: Belongs to the UPF0473 family.

591001:ACFER RS07385
gene id: 591001:ACFER_RS07385
uniprot id: D2RL58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591001:ACFER RS05555
gene id: 591001:ACFER_RS05555
uniprot id: D2RK47
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

591001:ACFER RS10650
gene id: 591001:ACFER_RS10650
uniprot id: D2RN06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

591001:ACFER RS04010
gene id: 591001:ACFER_RS04010
uniprot id: D2RJ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

591001:ACFER RS10305
gene id: 591001:ACFER_RS10305
uniprot id: D2RMQ9
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS00750
gene id: 591001:ACFER_RS00750
uniprot id: D2RNC2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

591001:ACFER RS04615
gene id: 591001:ACFER_RS04615
uniprot id: D2RJL6
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS11900
gene id: 591001:ACFER_RS11900
uniprot id: D2RJ59
names: Caution
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS03335
gene id: 591001:ACFER_RS03335
uniprot id: D2RIX8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

591001:ACFER RS08290
gene id: 591001:ACFER_RS08290
uniprot id: D2RLN3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09735
gene id: 591001:ACFER_RS09735
uniprot id: D2RME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

591001:ACFER RS09905
gene id: 591001:ACFER_RS09905
uniprot id: D2RMI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

591001:ACFER RS02635
gene id: 591001:ACFER_RS02635
uniprot id: D2RIK0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

591001:ACFER RS01375
gene id: 591001:ACFER_RS01375
uniprot id: D2RNN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

591001:ACFER RS10740
gene id: 591001:ACFER_RS10740
uniprot id: D2RNE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell surface

591001:ACFER RS08995
gene id: 591001:ACFER_RS08995
uniprot id: D2RM17
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

591001:ACFER RS07090
gene id: 591001:ACFER_RS07090
uniprot id: D2RL02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

591001:ACFER RS09770
gene id: 591001:ACFER_RS09770
uniprot id: D2RMF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

591001:ACFER RS10640
gene id: 591001:ACFER_RS10640
uniprot id: D2RN04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

591001:ACFER RS02315
gene id: 591001:ACFER_RS02315
uniprot id: D2RIE0
names: Similarity
messages: Belongs to the universal stress protein A family.

591001:ACFER RS02225
gene id: 591001:ACFER_RS02225
uniprot id: D2RP48
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

591001:ACFER RS03750
gene id: 591001:ACFER_RS03750
uniprot id: D2RJ55
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

591001:ACFER RS00595
gene id: 591001:ACFER_RS00595
uniprot id: D2RN93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

591001:ACFER RS08275
gene id: 591001:ACFER_RS08275
uniprot id: D2RLN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

591001:ACFER RS07775
gene id: 591001:ACFER_RS07775
uniprot id: D2RLD5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

591001:ACFER RS00825
gene id: 591001:ACFER_RS00825
uniprot id: D2RND6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS00255
gene id: 591001:ACFER_RS00255
uniprot id: D2RN28
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

591001:ACFER RS04815
gene id: 591001:ACFER_RS04815
uniprot id: D2RJQ1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

591001:ACFER RS02535
gene id: 591001:ACFER_RS02535
uniprot id: D2RII1
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

591001:ACFER RS05135
gene id: 591001:ACFER_RS05135
uniprot id: D2RJV9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04350
gene id: 591001:ACFER_RS04350
uniprot id: D2RJG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS07235
gene id: 591001:ACFER_RS07235
uniprot id: D2RL28
names: Similarity
messages: Belongs to the RemA family.

591001:ACFER RS07510
gene id: 591001:ACFER_RS07510
uniprot id: D2RL82
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

591001:ACFER RS04735
gene id: 591001:ACFER_RS04735
uniprot id: D2RJN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

591001:ACFER RS06320
gene id: 591001:ACFER_RS06320
uniprot id: D2RKJ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

591001:ACFER RS02500
gene id: 591001:ACFER_RS02500
uniprot id: D2RIH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS07545
gene id: 591001:ACFER_RS07545
uniprot id: D2RL89
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

591001:ACFER RS04790
gene id: 591001:ACFER_RS04790
uniprot id: D2RJP6
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

591001:ACFER RS00410
gene id: 591001:ACFER_RS00410
uniprot id: D2RN56
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

591001:ACFER RS01905
gene id: 591001:ACFER_RS01905
uniprot id: D2RNZ0
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

591001:ACFER RS06920
gene id: 591001:ACFER_RS06920
uniprot id: D2RKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

591001:ACFER RS06835
gene id: 591001:ACFER_RS06835
uniprot id: D2RKV1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

591001:ACFER RS05205
gene id: 591001:ACFER_RS05205
uniprot id: D2RJX3
names: Function
names: Similarity
messages: Belongs to the LarC family.
messages: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.

591001:ACFER RS02280
gene id: 591001:ACFER_RS02280
uniprot id: D2RID3
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS00365
gene id: 591001:ACFER_RS00365
uniprot id: D2RN47
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

591001:ACFER RS01920
gene id: 591001:ACFER_RS01920
uniprot id: D2RNZ3
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

591001:ACFER RS09315
gene id: 591001:ACFER_RS09315
uniprot id: D2RM72
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

591001:ACFER RS06340
gene id: 591001:ACFER_RS06340
uniprot id: D2RKK2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

591001:ACFER RS05265
gene id: 591001:ACFER_RS05265
uniprot id: D2RJY4
names: Similarity
messages: Belongs to the CinA family.

591001:ACFER RS06450
gene id: 591001:ACFER_RS06450
uniprot id: D2RKM4
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS09680
gene id: 591001:ACFER_RS09680
uniprot id: D2RMD8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

591001:ACFER RS10410
gene id: 591001:ACFER_RS10410
uniprot id: D2RMS7
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

591001:ACFER RS00530
gene id: 591001:ACFER_RS00530
uniprot id: D2RN80
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01675
gene id: 591001:ACFER_RS01675
uniprot id: D2RNU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

591001:ACFER RS00445
gene id: 591001:ACFER_RS00445
uniprot id: D2RN63
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

591001:ACFER RS07120
gene id: 591001:ACFER_RS07120
uniprot id: D2RL08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

591001:ACFER RS00245
gene id: 591001:ACFER_RS00245
uniprot id: D2RN26
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

591001:ACFER RS00150
gene id: 591001:ACFER_RS00150
uniprot id: D2RMV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

591001:ACFER RS03360
gene id: 591001:ACFER_RS03360
uniprot id: D2RIY3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS05365
gene id: 591001:ACFER_RS05365
uniprot id: D2RK05
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

591001:ACFER RS04820
gene id: 591001:ACFER_RS04820
uniprot id: D2RJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

591001:ACFER RS07280
gene id: 591001:ACFER_RS07280
uniprot id: D2RL37
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

591001:ACFER RS11165
gene id: 591001:ACFER_RS11165
uniprot id: D2RMF6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

591001:ACFER RS07690
gene id: 591001:ACFER_RS07690
uniprot id: D2RLB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS03720
gene id: 591001:ACFER_RS03720
uniprot id: D2RJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

591001:ACFER RS01520
gene id: 591001:ACFER_RS01520
uniprot id: D2RNR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

591001:ACFER RS00480
gene id: 591001:ACFER_RS00480
uniprot id: D2RN70
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

591001:ACFER RS07020
gene id: 591001:ACFER_RS07020
uniprot id: D2RKY8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS03480
gene id: 591001:ACFER_RS03480
uniprot id: D2RJ07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

591001:ACFER RS07080
gene id: 591001:ACFER_RS07080
uniprot id: D2RL00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

591001:ACFER RS02105
gene id: 591001:ACFER_RS02105
uniprot id: D2RP24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

591001:ACFER RS00970
gene id: 591001:ACFER_RS00970
uniprot id: D2RNG5
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

591001:ACFER RS03580
gene id: 591001:ACFER_RS03580
uniprot id: D2RJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spermidine/spermine synthase family.
messages: Cell membrane

591001:ACFER RS02485
gene id: 591001:ACFER_RS02485
uniprot id: D2RIH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

591001:ACFER RS05510
gene id: 591001:ACFER_RS05510
uniprot id: D2RK37
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS10015
gene id: 591001:ACFER_RS10015
uniprot id: D2RMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

591001:ACFER RS03690
gene id: 591001:ACFER_RS03690
uniprot id: D2RJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

591001:ACFER RS07410
gene id: 591001:ACFER_RS07410
uniprot id: D2RL63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

591001:ACFER RS01995
gene id: 591001:ACFER_RS01995
uniprot id: D2RP09
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

591001:ACFER RS07045
gene id: 591001:ACFER_RS07045
uniprot id: D2RKZ3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

591001:ACFER RS09395
gene id: 591001:ACFER_RS09395
uniprot id: Q9ZAA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Cell membrane
messages: Heterooctamer consisting of two alpha, two beta, two gamma and two delta subunits.
messages: Part of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). Possible membrane anchor for the alpha subunit.

591001:ACFER RS09685
gene id: 591001:ACFER_RS09685
uniprot id: D2RMD9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS10290
gene id: 591001:ACFER_RS10290
uniprot id: D2RMQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS01780
gene id: 591001:ACFER_RS01780
uniprot id: D2RNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS01500
gene id: 591001:ACFER_RS01500
uniprot id: D2RNR3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04095
gene id: 591001:ACFER_RS04095
uniprot id: D2RJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS09805
gene id: 591001:ACFER_RS09805
uniprot id: D2RMG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

591001:ACFER RS03405
gene id: 591001:ACFER_RS03405
uniprot id: D2RIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS01510
gene id: 591001:ACFER_RS01510
uniprot id: D2RNR5
names: Similarity
messages: Belongs to the TrpF family.

591001:ACFER RS06715
gene id: 591001:ACFER_RS06715
uniprot id: D2RKS7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

591001:ACFER RS10655
gene id: 591001:ACFER_RS10655
uniprot id: D2RN07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

591001:ACFER RS11750
gene id: 591001:ACFER_RS11750
uniprot id: D2RJC2
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

591001:ACFER RS02250
gene id: 591001:ACFER_RS02250
uniprot id: D2RP53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS05120
gene id: 591001:ACFER_RS05120
uniprot id: D2RJV6
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

591001:ACFER RS07470
gene id: 591001:ACFER_RS07470
uniprot id: D2RL74
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

591001:ACFER RS10190
gene id: 591001:ACFER_RS10190
uniprot id: D2RMN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

591001:ACFER RS07030
gene id: 591001:ACFER_RS07030
uniprot id: D2RKZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

591001:ACFER RS00920
gene id: 591001:ACFER_RS00920
uniprot id: D2RNF5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09790
gene id: 591001:ACFER_RS09790
uniprot id: D2RMG1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

591001:ACFER RS03040
gene id: 591001:ACFER_RS03040
uniprot id: D2RIS6
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

591001:ACFER RS08485
gene id: 591001:ACFER_RS08485
uniprot id: D2RLR7
names: Similarity
messages: Belongs to the IMPACT family.

591001:ACFER RS04510
gene id: 591001:ACFER_RS04510
uniprot id: D2RJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS03425
gene id: 591001:ACFER_RS03425
uniprot id: D2RIZ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

591001:ACFER RS05400
gene id: 591001:ACFER_RS05400
uniprot id: D2RK12
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07715
gene id: 591001:ACFER_RS07715
uniprot id: D2RLC3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

591001:ACFER RS04335
gene id: 591001:ACFER_RS04335
uniprot id: D2RJG1
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS06855
gene id: 591001:ACFER_RS06855
uniprot id: D2RKV5
names: Similarity
messages: Belongs to the class-I fumarase family.

591001:ACFER RS04555
gene id: 591001:ACFER_RS04555
uniprot id: D2RJK5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

591001:ACFER RS00260
gene id: 591001:ACFER_RS00260
uniprot id: D2RN29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

591001:ACFER RS04090
gene id: 591001:ACFER_RS04090
uniprot id: D2RJB4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

591001:ACFER RS07975
gene id: 591001:ACFER_RS07975
uniprot id: D2RLH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

591001:ACFER RS08345
gene id: 591001:ACFER_RS08345
uniprot id: D2RLP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

591001:ACFER RS02350
gene id: 591001:ACFER_RS02350
uniprot id: D2RIE7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

591001:ACFER RS08570
gene id: 591001:ACFER_RS08570
uniprot id: D2RLT4
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

591001:ACFER RS04860
gene id: 591001:ACFER_RS04860
uniprot id: D2RJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

591001:ACFER RS10145
gene id: 591001:ACFER_RS10145
uniprot id: D2RMM9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS04695
gene id: 591001:ACFER_RS04695
uniprot id: D2RJM7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

591001:ACFER RS09170
gene id: 591001:ACFER_RS09170
uniprot id: D2RM43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

591001:ACFER RS02720
gene id: 591001:ACFER_RS02720
uniprot id: D2RIL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

591001:ACFER RS06130
gene id: 591001:ACFER_RS06130
uniprot id: D2RKG0
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

591001:ACFER RS05170
gene id: 591001:ACFER_RS05170
uniprot id: D2RJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS06515
gene id: 591001:ACFER_RS06515
uniprot id: D2RKN7
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

591001:ACFER RS02965
gene id: 591001:ACFER_RS02965
uniprot id: D2RIQ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

591001:ACFER RS07005
gene id: 591001:ACFER_RS07005
uniprot id: D2RKY5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

591001:ACFER RS05185
gene id: 591001:ACFER_RS05185
uniprot id: D2RJW8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

591001:ACFER RS01700
gene id: 591001:ACFER_RS01700
uniprot id: D2RNV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

591001:ACFER RS10555
gene id: 591001:ACFER_RS10555
uniprot id: D2RMY8
names: Similarity
messages: Belongs to the sigma-54 factor family.

591001:ACFER RS08430
gene id: 591001:ACFER_RS08430
uniprot id: D2RLQ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

591001:ACFER RS06090
gene id: 591001:ACFER_RS06090
uniprot id: D2RKF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

591001:ACFER RS08740
gene id: 591001:ACFER_RS08740
uniprot id: D2RLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

591001:ACFER RS06195
gene id: 591001:ACFER_RS06195
uniprot id: D2RKH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS02985
gene id: 591001:ACFER_RS02985
uniprot id: D2RIR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

591001:ACFER RS06695
gene id: 591001:ACFER_RS06695
uniprot id: D2RKS3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

591001:ACFER RS06170
gene id: 591001:ACFER_RS06170
uniprot id: D2RKG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

591001:ACFER RS03150
gene id: 591001:ACFER_RS03150
uniprot id: D2RIU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Cell membrane
messages: Probably a homodimer.

591001:ACFER RS09595
gene id: 591001:ACFER_RS09595
uniprot id: D2RMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell surface

591001:ACFER RS03220
gene id: 591001:ACFER_RS03220
uniprot id: D2RIV6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

591001:ACFER RS06935
gene id: 591001:ACFER_RS06935
uniprot id: D2RKX1
names: Similarity
messages: Belongs to the peptidase M20A family.

591001:ACFER RS03125
gene id: 591001:ACFER_RS03125
uniprot id: D2RIT9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

591001:ACFER RS05405
gene id: 591001:ACFER_RS05405
uniprot id: D2RK13
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02855
gene id: 591001:ACFER_RS02855
uniprot id: D2RIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

591001:ACFER RS06470
gene id: 591001:ACFER_RS06470
uniprot id: D2RKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

591001:ACFER RS09860
gene id: 591001:ACFER_RS09860
uniprot id: D2RMH5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

591001:ACFER RS08295
gene id: 591001:ACFER_RS08295
uniprot id: D2RLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

591001:ACFER RS00720
gene id: 591001:ACFER_RS00720
uniprot id: D2RNB6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09625
gene id: 591001:ACFER_RS09625
uniprot id: D2RMC8
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS10425
gene id: 591001:ACFER_RS10425
uniprot id: D2RMT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

591001:ACFER RS03180
gene id: 591001:ACFER_RS03180
uniprot id: D2RIV1
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

591001:ACFER RS04005
gene id: 591001:ACFER_RS04005
uniprot id: D2RJ97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

591001:ACFER RS06700
gene id: 591001:ACFER_RS06700
uniprot id: D2RKS4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04035
gene id: 591001:ACFER_RS04035
uniprot id: D2RJA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

591001:ACFER RS06880
gene id: 591001:ACFER_RS06880
uniprot id: D2RKW0
names: Similarity
messages: Belongs to the ribF family.

591001:ACFER RS07380
gene id: 591001:ACFER_RS07380
uniprot id: D2RL57
names: Caution
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09800
gene id: 591001:ACFER_RS09800
uniprot id: D2RMG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

591001:ACFER RS09060
gene id: 591001:ACFER_RS09060
uniprot id: D2RM26
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

591001:ACFER RS05735
gene id: 591001:ACFER_RS05735
uniprot id: D2RK81
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

591001:ACFER RS09200
gene id: 591001:ACFER_RS09200
uniprot id: D2RM49
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

591001:ACFER RS00045
gene id: 591001:ACFER_RS00045
uniprot id: D2RMT8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

591001:ACFER RS06105
gene id: 591001:ACFER_RS06105
uniprot id: D2RKF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

591001:ACFER RS02490
gene id: 591001:ACFER_RS02490
uniprot id: D2RIH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

591001:ACFER RS03465
gene id: 591001:ACFER_RS03465
uniprot id: D2RJ04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

591001:ACFER RS01515
gene id: 591001:ACFER_RS01515
uniprot id: D2RNR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

591001:ACFER RS07105
gene id: 591001:ACFER_RS07105
uniprot id: D2RL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

591001:ACFER RS07075
gene id: 591001:ACFER_RS07075
uniprot id: D2RKZ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

591001:ACFER RS01785
gene id: 591001:ACFER_RS01785
uniprot id: D2RNW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS02120
gene id: 591001:ACFER_RS02120
uniprot id: D2RP27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

591001:ACFER RS06705
gene id: 591001:ACFER_RS06705
uniprot id: D2RKS5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

591001:ACFER RS07370
gene id: 591001:ACFER_RS07370
uniprot id: D2RL55
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

591001:ACFER RS03550
gene id: 591001:ACFER_RS03550
uniprot id: D2RJ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

591001:ACFER RS06525
gene id: 591001:ACFER_RS06525
uniprot id: D2RKN9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

591001:ACFER RS10310
gene id: 591001:ACFER_RS10310
uniprot id: D2RMR0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS00070
gene id: 591001:ACFER_RS00070
uniprot id: D2RMU3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS00895
gene id: 591001:ACFER_RS00895
uniprot id: D2RNF0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

591001:ACFER RS08800
gene id: 591001:ACFER_RS08800
uniprot id: D2RLY0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

591001:ACFER RS09385
gene id: 591001:ACFER_RS09385
uniprot id: Q9ZAA6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Cell membrane
messages: Heterooctamer consisting of two alpha, two beta, two gamma and two delta subunits.
messages: The N-terminus is blocked.
messages: Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).

591001:ACFER RS06465
gene id: 591001:ACFER_RS06465
uniprot id: D2RKM7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

591001:ACFER RS01165
gene id: 591001:ACFER_RS01165
uniprot id: D2RNK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS10100
gene id: 591001:ACFER_RS10100
uniprot id: D2RMM2
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

591001:ACFER RS08360
gene id: 591001:ACFER_RS08360
uniprot id: D2RLP7
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS04825
gene id: 591001:ACFER_RS04825
uniprot id: D2RJQ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

591001:ACFER RS06885
gene id: 591001:ACFER_RS06885
uniprot id: D2RKW1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

591001:ACFER RS03525
gene id: 591001:ACFER_RS03525
uniprot id: D2RJ11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

591001:ACFER RS11445
gene id: 591001:ACFER_RS11445
uniprot id: D2RLC9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

591001:ACFER RS02150
gene id: 591001:ACFER_RS02150
uniprot id: D2RP33
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01385
gene id: 591001:ACFER_RS01385
uniprot id: D2RNP0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

591001:ACFER RS07720
gene id: 591001:ACFER_RS07720
uniprot id: D2RLC4
names: Similarity
messages: Belongs to the RecJ family.

591001:ACFER RS01410
gene id: 591001:ACFER_RS01410
uniprot id: D2RNP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS02025
gene id: 591001:ACFER_RS02025
uniprot id: D2RP15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

591001:ACFER RS02580
gene id: 591001:ACFER_RS02580
uniprot id: D2RIJ0
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

591001:ACFER RS05190
gene id: 591001:ACFER_RS05190
uniprot id: D2RJW9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

591001:ACFER RS06765
gene id: 591001:ACFER_RS06765
uniprot id: D2RKT7
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

591001:ACFER RS04480
gene id: 591001:ACFER_RS04480
uniprot id: D2RJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

591001:ACFER RS00220
gene id: 591001:ACFER_RS00220
uniprot id: D2RN21
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

591001:ACFER RS03300
gene id: 591001:ACFER_RS03300
uniprot id: D2RIX1
names: Similarity
messages: Belongs to the PrpF family.

591001:ACFER RS09340
gene id: 591001:ACFER_RS09340
uniprot id: D2RM77
names: Similarity
messages: Belongs to the transpeptidase family.

591001:ACFER RS07110
gene id: 591001:ACFER_RS07110
uniprot id: D2RL06
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

591001:ACFER RS08065
gene id: 591001:ACFER_RS08065
uniprot id: D2RLI8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

591001:ACFER RS01820
gene id: 591001:ACFER_RS01820
uniprot id: D2RNX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

591001:ACFER RS04075
gene id: 591001:ACFER_RS04075
uniprot id: D2RJB1
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07125
gene id: 591001:ACFER_RS07125
uniprot id: D2RL09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04040
gene id: 591001:ACFER_RS04040
uniprot id: D2RJA4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

591001:ACFER RS03790
gene id: 591001:ACFER_RS03790
uniprot id: D2RJ63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

591001:ACFER RS05035
gene id: 591001:ACFER_RS05035
uniprot id: D2RJU1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS06775
gene id: 591001:ACFER_RS06775
uniprot id: D2RKT9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

591001:ACFER RS02470
gene id: 591001:ACFER_RS02470
uniprot id: D2RIG8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

591001:ACFER RS04430
gene id: 591001:ACFER_RS04430
uniprot id: D2RJI0
names: Similarity
messages: Belongs to the asp23 family.

591001:ACFER RS00820
gene id: 591001:ACFER_RS00820
uniprot id: D2RND5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

591001:ACFER RS07350
gene id: 591001:ACFER_RS07350
uniprot id: D2RL51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

591001:ACFER RS02725
gene id: 591001:ACFER_RS02725
uniprot id: D2RIL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

591001:ACFER RS04120
gene id: 591001:ACFER_RS04120
uniprot id: D2RJB9
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

591001:ACFER RS00280
gene id: 591001:ACFER_RS00280
uniprot id: D2RN30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS11015
gene id: 591001:ACFER_RS11015
uniprot id: D2RJR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS03295
gene id: 591001:ACFER_RS03295
uniprot id: D2RIX0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS06205
gene id: 591001:ACFER_RS06205
uniprot id: D2RKH4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

591001:ACFER RS04920
gene id: 591001:ACFER_RS04920
uniprot id: D2RJS2
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

591001:ACFER RS06845
gene id: 591001:ACFER_RS06845
uniprot id: D2RKV3
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS00010
gene id: 591001:ACFER_RS00010
uniprot id: D2RMT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

591001:ACFER RS05300
gene id: 591001:ACFER_RS05300
uniprot id: D2RJZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

591001:ACFER RS08765
gene id: 591001:ACFER_RS08765
uniprot id: D2RLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

591001:ACFER RS09810
gene id: 591001:ACFER_RS09810
uniprot id: D2RMG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

591001:ACFER RS00600
gene id: 591001:ACFER_RS00600
uniprot id: D2RN94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

591001:ACFER RS00730
gene id: 591001:ACFER_RS00730
uniprot id: D2RNB8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

591001:ACFER RS08880
gene id: 591001:ACFER_RS08880
uniprot id: D2RLZ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

591001:ACFER RS06635
gene id: 591001:ACFER_RS06635
uniprot id: D2RKR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07710
gene id: 591001:ACFER_RS07710
uniprot id: D2RLC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS00805
gene id: 591001:ACFER_RS00805
uniprot id: D2RND2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS06985
gene id: 591001:ACFER_RS06985
uniprot id: D2RKY1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

591001:ACFER RS01215
gene id: 591001:ACFER_RS01215
uniprot id: D2RNL2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

591001:ACFER RS05080
gene id: 591001:ACFER_RS05080
uniprot id: D2RJU9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

591001:ACFER RS05215
gene id: 591001:ACFER_RS05215
uniprot id: D2RJX5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03590
gene id: 591001:ACFER_RS03590
uniprot id: D2RJ24
names: Subcellular Location Annotation
messages: Cytoplasm

591001:ACFER RS09450
gene id: 591001:ACFER_RS09450
uniprot id: D2RMA0
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS10630
gene id: 591001:ACFER_RS10630
uniprot id: D2RN02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

591001:ACFER RS08365
gene id: 591001:ACFER_RS08365
uniprot id: D2RLP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
messages: Homodimer.

591001:ACFER RS09750
gene id: 591001:ACFER_RS09750
uniprot id: D2RMF2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

591001:ACFER RS00030
gene id: 591001:ACFER_RS00030
uniprot id: D2RMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

591001:ACFER RS07550
gene id: 591001:ACFER_RS07550
uniprot id: D2RL90
names: Similarity
messages: Belongs to the UPF0237 family.

591001:ACFER RS02940
gene id: 591001:ACFER_RS02940
uniprot id: D2RIQ4
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

591001:ACFER RS00315
gene id: 591001:ACFER_RS00315
uniprot id: D2RN37
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS00605
gene id: 591001:ACFER_RS00605
uniprot id: D2RN95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

591001:ACFER RS07785
gene id: 591001:ACFER_RS07785
uniprot id: D2RLD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

591001:ACFER RS08675
gene id: 591001:ACFER_RS08675
uniprot id: D2RLV5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

591001:ACFER RS07490
gene id: 591001:ACFER_RS07490
uniprot id: D2RL78
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

591001:ACFER RS00555
gene id: 591001:ACFER_RS00555
uniprot id: D2RN85
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

591001:ACFER RS03825
gene id: 591001:ACFER_RS03825
uniprot id: D2RJ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

591001:ACFER RS02925
gene id: 591001:ACFER_RS02925
uniprot id: D2RIQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

591001:ACFER RS08435
gene id: 591001:ACFER_RS08435
uniprot id: D2RLQ9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

591001:ACFER RS02420
gene id: 591001:ACFER_RS02420
uniprot id: D2RIF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

591001:ACFER RS07275
gene id: 591001:ACFER_RS07275
uniprot id: D2RL36
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09135
gene id: 591001:ACFER_RS09135
uniprot id: D2RM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

591001:ACFER RS01855
gene id: 591001:ACFER_RS01855
uniprot id: D2RNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). May be able to interact with more than 1 S component at a time (By similarity).
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

591001:ACFER RS02125
gene id: 591001:ACFER_RS02125
uniprot id: D2RP28
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

591001:ACFER RS02180
gene id: 591001:ACFER_RS02180
uniprot id: D2RP39
names: Similarity
messages: Belongs to the CitG/MdcB family.

591001:ACFER RS06915
gene id: 591001:ACFER_RS06915
uniprot id: D2RKW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

591001:ACFER RS09125
gene id: 591001:ACFER_RS09125
uniprot id: D2RM37
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

591001:ACFER RS02140
gene id: 591001:ACFER_RS02140
uniprot id: D2RP31
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

591001:ACFER RS04720
gene id: 591001:ACFER_RS04720
uniprot id: D2RJN2
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

591001:ACFER RS00295
gene id: 591001:ACFER_RS00295
uniprot id: D2RN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS07095
gene id: 591001:ACFER_RS07095
uniprot id: D2RL03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

591001:ACFER RS04635
gene id: 591001:ACFER_RS04635
uniprot id: D2RJM0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

591001:ACFER RS01025
gene id: 591001:ACFER_RS01025
uniprot id: D2RNH6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

591001:ACFER RS09000
gene id: 591001:ACFER_RS09000
uniprot id: D2RM18
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

591001:ACFER RS08720
gene id: 591001:ACFER_RS08720
uniprot id: D2RLW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

591001:ACFER RS03140
gene id: 591001:ACFER_RS03140
uniprot id: D2RIU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

591001:ACFER RS00760
gene id: 591001:ACFER_RS00760
uniprot id: D2RNC4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

591001:ACFER RS08920
gene id: 591001:ACFER_RS08920
uniprot id: D2RM02
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09845
gene id: 591001:ACFER_RS09845
uniprot id: D2RMH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

591001:ACFER RS02380
gene id: 591001:ACFER_RS02380
uniprot id: D2RIF0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

591001:ACFER RS00400
gene id: 591001:ACFER_RS00400
uniprot id: D2RN54
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

591001:ACFER RS02590
gene id: 591001:ACFER_RS02590
uniprot id: D2RIJ2
names: Similarity
messages: Belongs to the LOG family.

591001:ACFER RS09870
gene id: 591001:ACFER_RS09870
uniprot id: D2RMH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

591001:ACFER RS04875
gene id: 591001:ACFER_RS04875
uniprot id: D2RJR3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

591001:ACFER RS07420
gene id: 591001:ACFER_RS07420
uniprot id: D2RL64
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

591001:ACFER RS08040
gene id: 591001:ACFER_RS08040
uniprot id: D2RLI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

591001:ACFER RS01670
gene id: 591001:ACFER_RS01670
uniprot id: D2RNU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

591001:ACFER RS07780
gene id: 591001:ACFER_RS07780
uniprot id: D2RLD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

591001:ACFER RS01880
gene id: 591001:ACFER_RS01880
uniprot id: D2RNY5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

591001:ACFER RS04305
gene id: 591001:ACFER_RS04305
uniprot id: D2RJF5
names: Similarity
messages: Belongs to the DtxR/MntR family.

591001:ACFER RS06650
gene id: 591001:ACFER_RS06650
uniprot id: D2RKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

591001:ACFER RS06325
gene id: 591001:ACFER_RS06325
uniprot id: D2RKJ9
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

591001:ACFER RS05415
gene id: 591001:ACFER_RS05415
uniprot id: D2RK15
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

591001:ACFER RS02235
gene id: 591001:ACFER_RS02235
uniprot id: D2RP50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

591001:ACFER RS08055
gene id: 591001:ACFER_RS08055
uniprot id: D2RLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

591001:ACFER RS00835
gene id: 591001:ACFER_RS00835
uniprot id: D2RND8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

591001:ACFER RS01735
gene id: 591001:ACFER_RS01735
uniprot id: D2RNV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS01130
gene id: 591001:ACFER_RS01130
uniprot id: D2RNJ6
names: Similarity
messages: Belongs to the RutC family.

591001:ACFER RS05380
gene id: 591001:ACFER_RS05380
uniprot id: D2RK08
names: Similarity
messages: Belongs to the peptidase C1 family.

591001:ACFER RS06540
gene id: 591001:ACFER_RS06540
uniprot id: D2RKP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

591001:ACFER RS01975
gene id: 591001:ACFER_RS01975
uniprot id: D2RP05
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

591001:ACFER RS10615
gene id: 591001:ACFER_RS10615
uniprot id: D2RMZ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

591001:ACFER RS06615
gene id: 591001:ACFER_RS06615
uniprot id: D2RKQ7
names: Similarity
messages: Belongs to the UPF0749 family.

591001:ACFER RS08575
gene id: 591001:ACFER_RS08575
uniprot id: D2RLT5
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

591001:ACFER RS03495
gene id: 591001:ACFER_RS03495
uniprot id: D2RJ10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

591001:ACFER RS00875
gene id: 591001:ACFER_RS00875
uniprot id: D2RNE6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

591001:ACFER RS06185
gene id: 591001:ACFER_RS06185
uniprot id: D2RKH0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

591001:ACFER RS01545
gene id: 591001:ACFER_RS01545
uniprot id: D2RNS2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

591001:ACFER RS02340
gene id: 591001:ACFER_RS02340
uniprot id: D2RIE5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS00640
gene id: 591001:ACFER_RS00640
uniprot id: D2RNA2
names: Similarity
messages: Belongs to the transpeptidase family.

591001:ACFER RS08735
gene id: 591001:ACFER_RS08735
uniprot id: D2RLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

591001:ACFER RS09430
gene id: 591001:ACFER_RS09430
uniprot id: D2RM96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

591001:ACFER RS03210
gene id: 591001:ACFER_RS03210
uniprot id: D2RIV4
names: Similarity
messages: Belongs to the UPF0597 family.

591001:ACFER RS09560
gene id: 591001:ACFER_RS09560
uniprot id: D2RMB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

591001:ACFER RS06680
gene id: 591001:ACFER_RS06680
uniprot id: D2RKS0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09345
gene id: 591001:ACFER_RS09345
uniprot id: D2RM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

591001:ACFER RS02255
gene id: 591001:ACFER_RS02255
uniprot id: D2RP54
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

591001:ACFER RS02475
gene id: 591001:ACFER_RS02475
uniprot id: D2RIG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

591001:ACFER RS09865
gene id: 591001:ACFER_RS09865
uniprot id: D2RMH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

591001:ACFER RS09855
gene id: 591001:ACFER_RS09855
uniprot id: D2RMH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

591001:ACFER RS02650
gene id: 591001:ACFER_RS02650
uniprot id: D2RIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS00060
gene id: 591001:ACFER_RS00060
uniprot id: D2RMU1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

591001:ACFER RS01085
gene id: 591001:ACFER_RS01085
uniprot id: D2RNI7
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01620
gene id: 591001:ACFER_RS01620
uniprot id: D2RNT7
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

591001:ACFER RS05410
gene id: 591001:ACFER_RS05410
uniprot id: D2RK14
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS07605
gene id: 591001:ACFER_RS07605
uniprot id: D2RLA2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

591001:ACFER RS03045
gene id: 591001:ACFER_RS03045
uniprot id: D2RIS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

591001:ACFER RS08725
gene id: 591001:ACFER_RS08725
uniprot id: D2RLW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

591001:ACFER RS01845
gene id: 591001:ACFER_RS01845
uniprot id: D2RNX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

591001:ACFER RS08320
gene id: 591001:ACFER_RS08320
uniprot id: D2RLN9
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02305
gene id: 591001:ACFER_RS02305
uniprot id: D2RID8
names: Similarity
messages: Belongs to the universal stress protein A family.

591001:ACFER RS06975
gene id: 591001:ACFER_RS06975
uniprot id: D2RKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

591001:ACFER RS02695
gene id: 591001:ACFER_RS02695
uniprot id: D2RIL2
names: Similarity
messages: Belongs to the GSP E family.

591001:ACFER RS03630
gene id: 591001:ACFER_RS03630
uniprot id: D2RJ31
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

591001:ACFER RS02325
gene id: 591001:ACFER_RS02325
uniprot id: D2RIE2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

591001:ACFER RS02575
gene id: 591001:ACFER_RS02575
uniprot id: D2RII9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

591001:ACFER RS08140
gene id: 591001:ACFER_RS08140
uniprot id: D2RLK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

591001:ACFER RS02130
gene id: 591001:ACFER_RS02130
uniprot id: D2RP29
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

591001:ACFER RS06770
gene id: 591001:ACFER_RS06770
uniprot id: D2RKT8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04885
gene id: 591001:ACFER_RS04885
uniprot id: D2RJR5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

591001:ACFER RS06850
gene id: 591001:ACFER_RS06850
uniprot id: D2RKV4
names: Similarity
messages: Belongs to the class-I fumarase family.

591001:ACFER RS04450
gene id: 591001:ACFER_RS04450
uniprot id: D2RJI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

591001:ACFER RS01885
gene id: 591001:ACFER_RS01885
uniprot id: D2RNY6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

591001:ACFER RS09745
gene id: 591001:ACFER_RS09745
uniprot id: D2RMF1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

591001:ACFER RS04460
gene id: 591001:ACFER_RS04460
uniprot id: D2RJI6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

591001:ACFER RS00225
gene id: 591001:ACFER_RS00225
uniprot id: D2RN22
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

591001:ACFER RS09090
gene id: 591001:ACFER_RS09090
uniprot id: D2RM31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

591001:ACFER RS05095
gene id: 591001:ACFER_RS05095
uniprot id: D2RJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

591001:ACFER RS01590
gene id: 591001:ACFER_RS01590
uniprot id: D2RNT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

591001:ACFER RS04530
gene id: 591001:ACFER_RS04530
uniprot id: D2RJK0
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

591001:ACFER RS09620
gene id: 591001:ACFER_RS09620
uniprot id: D2RMC7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS02215
gene id: 591001:ACFER_RS02215
uniprot id: D2RP46
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

591001:ACFER RS01430
gene id: 591001:ACFER_RS01430
uniprot id: D2RNP9
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

591001:ACFER RS02705
gene id: 591001:ACFER_RS02705
uniprot id: D2RIL4
names: Similarity
messages: Belongs to the UPF0234 family.

591001:ACFER RS09945
gene id: 591001:ACFER_RS09945
uniprot id: D2RMJ2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

591001:ACFER RS07455
gene id: 591001:ACFER_RS07455
uniprot id: D2RL71
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02345
gene id: 591001:ACFER_RS02345
uniprot id: D2RIE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

591001:ACFER RS04865
gene id: 591001:ACFER_RS04865
uniprot id: D2RJR1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

591001:ACFER RS03035
gene id: 591001:ACFER_RS03035
uniprot id: D2RIS5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

591001:ACFER RS06360
gene id: 591001:ACFER_RS06360
uniprot id: D2RKK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

591001:ACFER RS01155
gene id: 591001:ACFER_RS01155
uniprot id: D2RNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

591001:ACFER RS01095
gene id: 591001:ACFER_RS01095
uniprot id: D2RNI9
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS00520
gene id: 591001:ACFER_RS00520
uniprot id: D2RN78
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS08020
gene id: 591001:ACFER_RS08020
uniprot id: D2RLH9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS04100
gene id: 591001:ACFER_RS04100
uniprot id: D2RJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS07345
gene id: 591001:ACFER_RS07345
uniprot id: D2RL50
names: Similarity
messages: Belongs to the UDPGP type 2 family.

591001:ACFER RS09875
gene id: 591001:ACFER_RS09875
uniprot id: D2RMH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

591001:ACFER RS09460
gene id: 591001:ACFER_RS09460
uniprot id: D2RMA2
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

591001:ACFER RS00330
gene id: 591001:ACFER_RS00330
uniprot id: D2RN40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09730
gene id: 591001:ACFER_RS09730
uniprot id: D2RME8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

591001:ACFER RS05085
gene id: 591001:ACFER_RS05085
uniprot id: D2RJV0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

591001:ACFER RS07580
gene id: 591001:ACFER_RS07580
uniprot id: D2RL97
names: Similarity
messages: Belongs to the thioredoxin family.

591001:ACFER RS05310
gene id: 591001:ACFER_RS05310
uniprot id: D2RJZ3
names: Similarity
messages: Belongs to the asp23 family.

591001:ACFER RS01290
gene id: 591001:ACFER_RS01290
uniprot id: D2RNM6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

591001:ACFER RS02735
gene id: 591001:ACFER_RS02735
uniprot id: D2RIM0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS07540
gene id: 591001:ACFER_RS07540
uniprot id: D2RL88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

591001:ACFER RS08835
gene id: 591001:ACFER_RS08835
uniprot id: D2RLY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

591001:ACFER RS10435
gene id: 591001:ACFER_RS10435
uniprot id: D2RMW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
messages: Cell surface

591001:ACFER RS01695
gene id: 591001:ACFER_RS01695
uniprot id: D2RNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

591001:ACFER RS04665
gene id: 591001:ACFER_RS04665
uniprot id: D2RJM3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

591001:ACFER RS01305
gene id: 591001:ACFER_RS01305
uniprot id: D2RNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS09720
gene id: 591001:ACFER_RS09720
uniprot id: D2RME6
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

591001:ACFER RS06355
gene id: 591001:ACFER_RS06355
uniprot id: D2RKK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS03285
gene id: 591001:ACFER_RS03285
uniprot id: D2RIW8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

591001:ACFER RS00755
gene id: 591001:ACFER_RS00755
uniprot id: D2RNC3
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

591001:ACFER RS10455
gene id: 591001:ACFER_RS10455
uniprot id: D2RMX0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

591001:ACFER RS01815
gene id: 591001:ACFER_RS01815
uniprot id: D2RNX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

591001:ACFER RS08250
gene id: 591001:ACFER_RS08250
uniprot id: D2RLM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

591001:ACFER RS00085
gene id: 591001:ACFER_RS00085
uniprot id: D2RMU6
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02320
gene id: 591001:ACFER_RS02320
uniprot id: D2RIE1
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS02495
gene id: 591001:ACFER_RS02495
uniprot id: D2RIH3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

591001:ACFER RS09895
gene id: 591001:ACFER_RS09895
uniprot id: D2RMI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

591001:ACFER RS09820
gene id: 591001:ACFER_RS09820
uniprot id: D2RMG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

591001:ACFER RS00075
gene id: 591001:ACFER_RS00075
uniprot id: D2RMU4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

591001:ACFER RS08370
gene id: 591001:ACFER_RS08370
uniprot id: D2RLP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

591001:ACFER RS07230
gene id: 591001:ACFER_RS07230
uniprot id: D2RL27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

591001:ACFER RS10095
gene id: 591001:ACFER_RS10095
uniprot id: D2RMM1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS05655
gene id: 591001:ACFER_RS05655
uniprot id: D2RK68
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

591001:ACFER RS09795
gene id: 591001:ACFER_RS09795
uniprot id: D2RMG2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

591001:ACFER RS02505
gene id: 591001:ACFER_RS02505
uniprot id: D2RIH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

591001:ACFER RS09250
gene id: 591001:ACFER_RS09250
uniprot id: D2RM59
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

591001:ACFER RS06565
gene id: 591001:ACFER_RS06565
uniprot id: D2RKP7
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

591001:ACFER RS03700
gene id: 591001:ACFER_RS03700
uniprot id: D2RJ45
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

591001:ACFER RS02210
gene id: 591001:ACFER_RS02210
uniprot id: D2RP45
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS02300
gene id: 591001:ACFER_RS02300
uniprot id: D2RID7
names: Similarity
messages: Belongs to the universal stress protein A family.

591001:ACFER RS01240
gene id: 591001:ACFER_RS01240
uniprot id: D2RNL8
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

591001:ACFER RS09475
gene id: 591001:ACFER_RS09475
uniprot id: D2RMA5
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

591001:ACFER RS06995
gene id: 591001:ACFER_RS06995
uniprot id: D2RKY3
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS02295
gene id: 591001:ACFER_RS02295
uniprot id: D2RID6
names: Similarity
messages: Belongs to the universal stress protein A family.

591001:ACFER RS06945
gene id: 591001:ACFER_RS06945
uniprot id: D2RKX3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS00355
gene id: 591001:ACFER_RS00355
uniprot id: D2RN45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

591001:ACFER RS01955
gene id: 591001:ACFER_RS01955
uniprot id: D2RP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

591001:ACFER RS08200
gene id: 591001:ACFER_RS08200
uniprot id: D2RLL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS00175
gene id: 591001:ACFER_RS00175
uniprot id: D2RMW0
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

591001:ACFER RS01940
gene id: 591001:ACFER_RS01940
uniprot id: D2RNZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

591001:ACFER RS05210
gene id: 591001:ACFER_RS05210
uniprot id: D2RJX4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS00740
gene id: 591001:ACFER_RS00740
uniprot id: D2RNC0
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01140
gene id: 591001:ACFER_RS01140
uniprot id: D2RNJ8
names: Similarity
messages: Belongs to the arginase family.

591001:ACFER RS02655
gene id: 591001:ACFER_RS02655
uniprot id: D2RIK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

591001:ACFER RS09265
gene id: 591001:ACFER_RS09265
uniprot id: D2RM62
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08770
gene id: 591001:ACFER_RS08770
uniprot id: D2RLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

591001:ACFER RS07755
gene id: 591001:ACFER_RS07755
uniprot id: D2RLD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

591001:ACFER RS00240
gene id: 591001:ACFER_RS00240
uniprot id: D2RN25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

591001:ACFER RS00950
gene id: 591001:ACFER_RS00950
uniprot id: D2RNG1
names: Similarity
messages: Belongs to the peptidase M29 family.

591001:ACFER RS03025
gene id: 591001:ACFER_RS03025
uniprot id: D2RIS3
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

591001:ACFER RS00865
gene id: 591001:ACFER_RS00865
uniprot id: D2RNE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

591001:ACFER RS02915
gene id: 591001:ACFER_RS02915
uniprot id: D2RIP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS07440
gene id: 591001:ACFER_RS07440
uniprot id: D2RL68
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

591001:ACFER RS01455
gene id: 591001:ACFER_RS01455
uniprot id: D2RNQ4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07655
gene id: 591001:ACFER_RS07655
uniprot id: D2RLB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

591001:ACFER RS08810
gene id: 591001:ACFER_RS08810
uniprot id: D2RLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

591001:ACFER RS00645
gene id: 591001:ACFER_RS00645
uniprot id: D2RNA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

591001:ACFER RS01650
gene id: 591001:ACFER_RS01650
uniprot id: D2RNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

591001:ACFER RS07800
gene id: 591001:ACFER_RS07800
uniprot id: D2RLE0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS03455
gene id: 591001:ACFER_RS03455
uniprot id: D2RJ02
names: Similarity
messages: Belongs to the peptidase S41A family.

591001:ACFER RS07290
gene id: 591001:ACFER_RS07290
uniprot id: D2RL39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

591001:ACFER RS03775
gene id: 591001:ACFER_RS03775
uniprot id: D2RJ60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS02860
gene id: 591001:ACFER_RS02860
uniprot id: D2RIP2
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

591001:ACFER RS06875
gene id: 591001:ACFER_RS06875
uniprot id: D2RKV9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

591001:ACFER RS03305
gene id: 591001:ACFER_RS03305
uniprot id: D2RIX2
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03135
gene id: 591001:ACFER_RS03135
uniprot id: D2RIU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

591001:ACFER RS06295
gene id: 591001:ACFER_RS06295
uniprot id: D2RKJ3
names: Similarity
messages: Belongs to the UPF0735 family.

591001:ACFER RS00845
gene id: 591001:ACFER_RS00845
uniprot id: D2RNE0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04690
gene id: 591001:ACFER_RS04690
uniprot id: D2RJM6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

591001:ACFER RS03725
gene id: 591001:ACFER_RS03725
uniprot id: D2RJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

591001:ACFER RS11190
gene id: 591001:ACFER_RS11190
uniprot id: D2RN08
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

591001:ACFER RS10970
gene id: 591001:ACFER_RS10970
uniprot id: D2RIR9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

591001:ACFER RS02405
gene id: 591001:ACFER_RS02405
uniprot id: D2RIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

591001:ACFER RS00250
gene id: 591001:ACFER_RS00250
uniprot id: D2RN27
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

591001:ACFER RS10385
gene id: 591001:ACFER_RS10385
uniprot id: D2RMS2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

591001:ACFER RS04470
gene id: 591001:ACFER_RS04470
uniprot id: D2RJI8
names: Similarity
messages: Belongs to the TlyA family.

591001:ACFER RS08790
gene id: 591001:ACFER_RS08790
uniprot id: D2RLX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

591001:ACFER RS07360
gene id: 591001:ACFER_RS07360
uniprot id: D2RL53
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS01225
gene id: 591001:ACFER_RS01225
uniprot id: D2RNL4
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01585
gene id: 591001:ACFER_RS01585
uniprot id: D2RNT0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS04160
gene id: 591001:ACFER_RS04160
uniprot id: D2RJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

591001:ACFER RS06260
gene id: 591001:ACFER_RS06260
uniprot id: D2RKI6
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS09480
gene id: 591001:ACFER_RS09480
uniprot id: D2RMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

591001:ACFER RS08985
gene id: 591001:ACFER_RS08985
uniprot id: D2RM15
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

591001:ACFER RS03685
gene id: 591001:ACFER_RS03685
uniprot id: D2RJ42
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

591001:ACFER RS07840
gene id: 591001:ACFER_RS07840
uniprot id: D2RLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

591001:ACFER RS03440
gene id: 591001:ACFER_RS03440
uniprot id: D2RIZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

591001:ACFER RS02935
gene id: 591001:ACFER_RS02935
uniprot id: D2RIQ3
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

591001:ACFER RS00020
gene id: 591001:ACFER_RS00020
uniprot id: D2RMT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

591001:ACFER RS03330
gene id: 591001:ACFER_RS03330
uniprot id: D2RIX7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

591001:ACFER RS05285
gene id: 591001:ACFER_RS05285
uniprot id: D2RJY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

591001:ACFER RS06505
gene id: 591001:ACFER_RS06505
uniprot id: D2RKN5
names: Similarity
messages: Belongs to the GARS family.

591001:ACFER RS06070
gene id: 591001:ACFER_RS06070
uniprot id: D2RKE8
names: Similarity
messages: Belongs to the bacterial secretin family.

591001:ACFER RS00435
gene id: 591001:ACFER_RS00435
uniprot id: D2RN61
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07695
gene id: 591001:ACFER_RS07695
uniprot id: D2RLB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS03415
gene id: 591001:ACFER_RS03415
uniprot id: D2RIZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

591001:ACFER RS08960
gene id: 591001:ACFER_RS08960
uniprot id: D2RM10
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

591001:ACFER RS05270
gene id: 591001:ACFER_RS05270
uniprot id: D2RJY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

591001:ACFER RS00940
gene id: 591001:ACFER_RS00940
uniprot id: D2RNF9
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

591001:ACFER RS10355
gene id: 591001:ACFER_RS10355
uniprot id: D2RMR7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09655
gene id: 591001:ACFER_RS09655
uniprot id: D2RMD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

591001:ACFER RS04475
gene id: 591001:ACFER_RS04475
uniprot id: D2RJI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS00880
gene id: 591001:ACFER_RS00880
uniprot id: D2RNE7
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03555
gene id: 591001:ACFER_RS03555
uniprot id: D2RJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

591001:ACFER RS08180
gene id: 591001:ACFER_RS08180
uniprot id: D2RLL1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

591001:ACFER RS08545
gene id: 591001:ACFER_RS08545
uniprot id: D2RLS9
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS09220
gene id: 591001:ACFER_RS09220
uniprot id: D2RM53
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06310
gene id: 591001:ACFER_RS06310
uniprot id: D2RKJ6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

591001:ACFER RS04730
gene id: 591001:ACFER_RS04730
uniprot id: D2RJN4
names: Similarity
messages: Belongs to the peptidase M24B family.

591001:ACFER RS05695
gene id: 591001:ACFER_RS05695
uniprot id: D2RK74
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

591001:ACFER RS05280
gene id: 591001:ACFER_RS05280
uniprot id: D2RJY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

591001:ACFER RS00980
gene id: 591001:ACFER_RS00980
uniprot id: D2RNG7
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

591001:ACFER RS10755
gene id: 591001:ACFER_RS10755
uniprot id: D2RNV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

591001:ACFER RS00975
gene id: 591001:ACFER_RS00975
uniprot id: D2RNG6
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

591001:ACFER RS09405
gene id: 591001:ACFER_RS09405
uniprot id: D2RM90
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

591001:ACFER RS09690
gene id: 591001:ACFER_RS09690
uniprot id: D2RME0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

591001:ACFER RS01080
gene id: 591001:ACFER_RS01080
uniprot id: D2RNI6
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS05890
gene id: 591001:ACFER_RS05890
uniprot id: D2RKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

591001:ACFER RS00735
gene id: 591001:ACFER_RS00735
uniprot id: D2RNB9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

591001:ACFER RS08645
gene id: 591001:ACFER_RS08645
uniprot id: D2RLU9
names: Similarity
messages: Belongs to the Skp family.

591001:ACFER RS09920
gene id: 591001:ACFER_RS09920
uniprot id: D2RMI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

591001:ACFER RS03105
gene id: 591001:ACFER_RS03105
uniprot id: D2RIT6
names: Similarity
messages: Belongs to the GPI family.

591001:ACFER RS01365
gene id: 591001:ACFER_RS01365
uniprot id: D2RMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

591001:ACFER RS10750
gene id: 591001:ACFER_RS10750
uniprot id: D2RNR8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

591001:ACFER RS04970
gene id: 591001:ACFER_RS04970
uniprot id: D2RJT0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09670
gene id: 591001:ACFER_RS09670
uniprot id: D2RMD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS04265
gene id: 591001:ACFER_RS04265
uniprot id: D2RJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

591001:ACFER RS06400
gene id: 591001:ACFER_RS06400
uniprot id: D2RKL4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

591001:ACFER RS01630
gene id: 591001:ACFER_RS01630
uniprot id: D2RNT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

591001:ACFER RS01370
gene id: 591001:ACFER_RS01370
uniprot id: D2RNN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

591001:ACFER RS07620
gene id: 591001:ACFER_RS07620
uniprot id: D2RLA5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08125
gene id: 591001:ACFER_RS08125
uniprot id: D2RLK0
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS11795
gene id: 591001:ACFER_RS11795
uniprot id: D2RK60
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

591001:ACFER RS04440
gene id: 591001:ACFER_RS04440
uniprot id: D2RJI2
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

591001:ACFER RS05330
gene id: 591001:ACFER_RS05330
uniprot id: D2RJZ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS04535
gene id: 591001:ACFER_RS04535
uniprot id: D2RJK1
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS10725
gene id: 591001:ACFER_RS10725
uniprot id: D2RMW4
names: Subcellular Location Annotation
messages: Cell surface

591001:ACFER RS05800
gene id: 591001:ACFER_RS05800
uniprot id: D2RK96
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

591001:ACFER RS07885
gene id: 591001:ACFER_RS07885
uniprot id: D2RLF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS03355
gene id: 591001:ACFER_RS03355
uniprot id: D2RIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

591001:ACFER RS01925
gene id: 591001:ACFER_RS01925
uniprot id: D2RNZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

591001:ACFER RS08930
gene id: 591001:ACFER_RS08930
uniprot id: D2RM04
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01310
gene id: 591001:ACFER_RS01310
uniprot id: D2RNN0
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

591001:ACFER RS08115
gene id: 591001:ACFER_RS08115
uniprot id: D2RLJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS09665
gene id: 591001:ACFER_RS09665
uniprot id: D2RMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

591001:ACFER RS01795
gene id: 591001:ACFER_RS01795
uniprot id: D2RNW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

591001:ACFER RS07255
gene id: 591001:ACFER_RS07255
uniprot id: D2RL32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS08830
gene id: 591001:ACFER_RS08830
uniprot id: D2RLY4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

591001:ACFER RS01900
gene id: 591001:ACFER_RS01900
uniprot id: D2RNY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

591001:ACFER RS04170
gene id: 591001:ACFER_RS04170
uniprot id: D2RJC8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

591001:ACFER RS09175
gene id: 591001:ACFER_RS09175
uniprot id: D2RM44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

591001:ACFER RS00470
gene id: 591001:ACFER_RS00470
uniprot id: D2RN68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS08135
gene id: 591001:ACFER_RS08135
uniprot id: D2RLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

591001:ACFER RS08730
gene id: 591001:ACFER_RS08730
uniprot id: D2RLW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

591001:ACFER RS07515
gene id: 591001:ACFER_RS07515
uniprot id: D2RL83
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

591001:ACFER RS04250
gene id: 591001:ACFER_RS04250
uniprot id: D2RJE4
names: Similarity
messages: Belongs to the peptidase C69 family.

591001:ACFER RS09435
gene id: 591001:ACFER_RS09435
uniprot id: D2RM97
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS08745
gene id: 591001:ACFER_RS08745
uniprot id: D2RLW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

591001:ACFER RS01000
gene id: 591001:ACFER_RS01000
uniprot id: D2RNH1
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

591001:ACFER RS01965
gene id: 591001:ACFER_RS01965
uniprot id: D2RP03
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS08910
gene id: 591001:ACFER_RS08910
uniprot id: D2RM00
names: Similarity
messages: Belongs to the UxaA family.

591001:ACFER RS02565
gene id: 591001:ACFER_RS02565
uniprot id: D2RII7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

591001:ACFER RS03675
gene id: 591001:ACFER_RS03675
uniprot id: D2RJ40
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

591001:ACFER RS10645
gene id: 591001:ACFER_RS10645
uniprot id: D2RN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

591001:ACFER RS01460
gene id: 591001:ACFER_RS01460
uniprot id: D2RNQ5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08600
gene id: 591001:ACFER_RS08600
uniprot id: D2RLU0
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

591001:ACFER RS01100
gene id: 591001:ACFER_RS01100
uniprot id: D2RNJ0
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS01330
gene id: 591001:ACFER_RS01330
uniprot id: D2RNN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS05340
gene id: 591001:ACFER_RS05340
uniprot id: D2RK00
names: Similarity
messages: Belongs to the peptidase A24 family.

591001:ACFER RS04805
gene id: 591001:ACFER_RS04805
uniprot id: D2RJP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

591001:ACFER RS08980
gene id: 591001:ACFER_RS08980
uniprot id: D2RM14
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

591001:ACFER RS00525
gene id: 591001:ACFER_RS00525
uniprot id: D2RN79
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

591001:ACFER RS08905
gene id: 591001:ACFER_RS08905
uniprot id: D2RLZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

591001:ACFER RS08630
gene id: 591001:ACFER_RS08630
uniprot id: D2RLU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

591001:ACFER RS02465
gene id: 591001:ACFER_RS02465
uniprot id: D2RIG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

591001:ACFER RS08855
gene id: 591001:ACFER_RS08855
uniprot id: D2RLY9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

591001:ACFER RS07575
gene id: 591001:ACFER_RS07575
uniprot id: D2RL96
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

591001:ACFER RS00335
gene id: 591001:ACFER_RS00335
uniprot id: D2RN41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS04425
gene id: 591001:ACFER_RS04425
uniprot id: D2RJH9
names: Similarity
messages: Belongs to the asp23 family.

591001:ACFER RS07520
gene id: 591001:ACFER_RS07520
uniprot id: D2RL84
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

591001:ACFER RS06645
gene id: 591001:ACFER_RS06645
uniprot id: D2RKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

591001:ACFER RS09815
gene id: 591001:ACFER_RS09815
uniprot id: D2RMG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

591001:ACFER RS02335
gene id: 591001:ACFER_RS02335
uniprot id: D2RIE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

591001:ACFER RS06055
gene id: 591001:ACFER_RS06055
uniprot id: D2RKE5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03365
gene id: 591001:ACFER_RS03365
uniprot id: D2RIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

591001:ACFER RS05385
gene id: 591001:ACFER_RS05385
uniprot id: D2RK09
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS08235
gene id: 591001:ACFER_RS08235
uniprot id: D2RLM2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

591001:ACFER RS05350
gene id: 591001:ACFER_RS05350
uniprot id: D2RK02
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

591001:ACFER RS09830
gene id: 591001:ACFER_RS09830
uniprot id: D2RMG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

591001:ACFER RS08305
gene id: 591001:ACFER_RS08305
uniprot id: D2RLN6
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06860
gene id: 591001:ACFER_RS06860
uniprot id: D2RKV6
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS03695
gene id: 591001:ACFER_RS03695
uniprot id: D2RJ44
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

591001:ACFER RS07660
gene id: 591001:ACFER_RS07660
uniprot id: D2RLB3
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

591001:ACFER RS01850
gene id: 591001:ACFER_RS01850
uniprot id: D2RNX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

591001:ACFER RS02700
gene id: 591001:ACFER_RS02700
uniprot id: D2RIL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

591001:ACFER RS08260
gene id: 591001:ACFER_RS08260
uniprot id: D2RLM7
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS10025
gene id: 591001:ACFER_RS10025
uniprot id: D2RMK8
names: Subcellular Location Annotation
messages: Cell membrane

591001:ACFER RS10685
gene id: 591001:ACFER_RS10685
uniprot id: D2RN14
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS00300
gene id: 591001:ACFER_RS00300
uniprot id: D2RN34
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS08310
gene id: 591001:ACFER_RS08310
uniprot id: D2RLN7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

591001:ACFER RS03265
gene id: 591001:ACFER_RS03265
uniprot id: D2RIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS09885
gene id: 591001:ACFER_RS09885
uniprot id: D2RMI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

591001:ACFER RS07270
gene id: 591001:ACFER_RS07270
uniprot id: D2RL35
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

591001:ACFER RS06100
gene id: 591001:ACFER_RS06100
uniprot id: D2RKF4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04840
gene id: 591001:ACFER_RS04840
uniprot id: D2RJQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS02160
gene id: 591001:ACFER_RS02160
uniprot id: D2RP35
names: Subcellular Location Annotation
messages: Cytoplasm

591001:ACFER RS09640
gene id: 591001:ACFER_RS09640
uniprot id: D2RMD1
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

591001:ACFER RS08150
gene id: 591001:ACFER_RS08150
uniprot id: D2RLK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

591001:ACFER RS09840
gene id: 591001:ACFER_RS09840
uniprot id: D2RMH1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

591001:ACFER RS01635
gene id: 591001:ACFER_RS01635
uniprot id: D2RNU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

591001:ACFER RS06315
gene id: 591001:ACFER_RS06315
uniprot id: D2RKJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09780
gene id: 591001:ACFER_RS09780
uniprot id: D2RMF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

591001:ACFER RS06980
gene id: 591001:ACFER_RS06980
uniprot id: D2RKY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

591001:ACFER RS02900
gene id: 591001:ACFER_RS02900
uniprot id: D2RIP6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

591001:ACFER RS00025
gene id: 591001:ACFER_RS00025
uniprot id: D2RMT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

591001:ACFER RS00055
gene id: 591001:ACFER_RS00055
uniprot id: D2RMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS00215
gene id: 591001:ACFER_RS00215
uniprot id: D2RN20
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

591001:ACFER RS02175
gene id: 591001:ACFER_RS02175
uniprot id: D2RP38
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS09260
gene id: 591001:ACFER_RS09260
uniprot id: D2RM61
names: Similarity
messages: Belongs to the peptidase M20A family.

591001:ACFER RS02660
gene id: 591001:ACFER_RS02660
uniprot id: D2RIK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

591001:ACFER RS04765
gene id: 591001:ACFER_RS04765
uniprot id: D2RJP1
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

591001:ACFER RS02665
gene id: 591001:ACFER_RS02665
uniprot id: D2RIK6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

591001:ACFER RS06710
gene id: 591001:ACFER_RS06710
uniprot id: D2RKS6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS01640
gene id: 591001:ACFER_RS01640
uniprot id: D2RNU1
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

591001:ACFER RS00285
gene id: 591001:ACFER_RS00285
uniprot id: D2RN31
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

591001:ACFER RS00620
gene id: 591001:ACFER_RS00620
uniprot id: D2RN98
names: Similarity
messages: Belongs to the peptidase C40 family.

591001:ACFER RS08860
gene id: 591001:ACFER_RS08860
uniprot id: D2RLZ0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

591001:ACFER RS10625
gene id: 591001:ACFER_RS10625
uniprot id: D2RN01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

591001:ACFER RS02730
gene id: 591001:ACFER_RS02730
uniprot id: D2RIL9
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

591001:ACFER RS07220
gene id: 591001:ACFER_RS07220
uniprot id: D2RL25
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS07015
gene id: 591001:ACFER_RS07015
uniprot id: D2RKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

591001:ACFER RS08590
gene id: 591001:ACFER_RS08590
uniprot id: D2RLT8
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

591001:ACFER RS08255
gene id: 591001:ACFER_RS08255
uniprot id: D2RLM6
names: Similarity
messages: Belongs to the FBPase class 2 family.

591001:ACFER RS03645
gene id: 591001:ACFER_RS03645
uniprot id: D2RJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

591001:ACFER RS08195
gene id: 591001:ACFER_RS08195
uniprot id: D2RLL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

591001:ACFER RS06655
gene id: 591001:ACFER_RS06655
uniprot id: D2RKR5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS05360
gene id: 591001:ACFER_RS05360
uniprot id: D2RK04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

591001:ACFER RS00590
gene id: 591001:ACFER_RS00590
uniprot id: D2RN92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

591001:ACFER RS03130
gene id: 591001:ACFER_RS03130
uniprot id: D2RIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

591001:ACFER RS02385
gene id: 591001:ACFER_RS02385
uniprot id: D2RIF1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

591001:ACFER RS01035
gene id: 591001:ACFER_RS01035
uniprot id: D2RNH8
names: Subcellular Location Annotation
messages: Cytoplasm

591001:ACFER RS01555
gene id: 591001:ACFER_RS01555
uniprot id: D2RNS4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS09335
gene id: 591001:ACFER_RS09335
uniprot id: D2RM76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

591001:ACFER RS07285
gene id: 591001:ACFER_RS07285
uniprot id: D2RL38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

591001:ACFER RS05090
gene id: 591001:ACFER_RS05090
uniprot id: D2RJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

591001:ACFER RS04965
gene id: 591001:ACFER_RS04965
uniprot id: D2RJS9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

591001:ACFER RS06690
gene id: 591001:ACFER_RS06690
uniprot id: D2RKS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

591001:ACFER RS02155
gene id: 591001:ACFER_RS02155
uniprot id: D2RP34
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07770
gene id: 591001:ACFER_RS07770
uniprot id: D2RLD4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

591001:ACFER RS06300
gene id: 591001:ACFER_RS06300
uniprot id: D2RKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

591001:ACFER RS01560
gene id: 591001:ACFER_RS01560
uniprot id: D2RNS5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS08875
gene id: 591001:ACFER_RS08875
uniprot id: D2RLZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

591001:ACFER RS03680
gene id: 591001:ACFER_RS03680
uniprot id: D2RJ41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

591001:ACFER RS07700
gene id: 591001:ACFER_RS07700
uniprot id: D2RLC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

591001:ACFER RS01505
gene id: 591001:ACFER_RS01505
uniprot id: D2RNR4
names: Similarity
messages: Belongs to the TrpC family.

591001:ACFER RS06685
gene id: 591001:ACFER_RS06685
uniprot id: D2RKS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

591001:ACFER RS07240
gene id: 591001:ACFER_RS07240
uniprot id: D2RL29
names: Similarity
messages: Belongs to the YicC/YloC family.

591001:ACFER RS05325
gene id: 591001:ACFER_RS05325
uniprot id: D2RJZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591001:ACFER RS08185
gene id: 591001:ACFER_RS08185
uniprot id: D2RLL2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS10065
gene id: 591001:ACFER_RS10065
uniprot id: D2RML5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS00770
gene id: 591001:ACFER_RS00770
uniprot id: D2RNC6
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

591001:ACFER RS05070
gene id: 591001:ACFER_RS05070
uniprot id: D2RJU7
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate.

591001:ACFER RS02515
gene id: 591001:ACFER_RS02515
uniprot id: D2RIH7
names: Similarity
messages: Belongs to the UPF0102 family.

591001:ACFER RS00985
gene id: 591001:ACFER_RS00985
uniprot id: D2RNG8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

591001:ACFER RS09390
gene id: 591001:ACFER_RS09390
uniprot id: Q9ZAA7
names: Function
names: Subunit
messages: Biotin carrier subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
messages: Heterooctamer consisting of two alpha, two beta, two gamma and two delta subunits.

591001:ACFER RS08635
gene id: 591001:ACFER_RS08635
uniprot id: D2RLU7
names: Similarity
messages: Belongs to the Skp family.

591001:ACFER RS01395
gene id: 591001:ACFER_RS01395
uniprot id: D2RNP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

591001:ACFER RS09850
gene id: 591001:ACFER_RS09850
uniprot id: D2RMH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

591001:ACFER RS00375
gene id: 591001:ACFER_RS00375
uniprot id: D2RN49
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

591001:ACFER RS10490
gene id: 591001:ACFER_RS10490
uniprot id: D2RMX7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

591001:ACFER RS01415
gene id: 591001:ACFER_RS01415
uniprot id: D2RNP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

591001:ACFER RS01400
gene id: 591001:ACFER_RS01400
uniprot id: D2RNP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

591001:ACFER RS00395
gene id: 591001:ACFER_RS00395
uniprot id: D2RN53
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS00725
gene id: 591001:ACFER_RS00725
uniprot id: D2RNB7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

591001:ACFER RS08045
gene id: 591001:ACFER_RS08045
uniprot id: D2RLI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

591001:ACFER RS09350
gene id: 591001:ACFER_RS09350
uniprot id: D2RM79
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

591001:ACFER RS00360
gene id: 591001:ACFER_RS00360
uniprot id: D2RN46
names: Similarity
messages: Belongs to the EamA transporter family.

591001:ACFER RS07630
gene id: 591001:ACFER_RS07630
uniprot id: D2RLA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591001:ACFER RS01200
gene id: 591001:ACFER_RS01200
uniprot id: D2RNK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

591001:ACFER RS00385
gene id: 591001:ACFER_RS00385
uniprot id: D2RN51
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

591001:ACFER RS07860
gene id: 591001:ACFER_RS07860
uniprot id: D2RLF2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS02245
gene id: 591001:ACFER_RS02245
uniprot id: D2RP52
names: Similarity
messages: Belongs to the UPF0340 family.

591001:ACFER RS09365
gene id: 591001:ACFER_RS09365
uniprot id: D2RM82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

591001:ACFER RS03310
gene id: 591001:ACFER_RS03310
uniprot id: D2RIX3
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

591001:ACFER RS02615
gene id: 591001:ACFER_RS02615
uniprot id: D2RIJ5
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS00145
gene id: 591001:ACFER_RS00145
uniprot id: D2RMV5
names: Subunit
messages: Homodimer.

591001:ACFER RS08805
gene id: 591001:ACFER_RS08805
uniprot id: D2RLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

591001:ACFER RS00565
gene id: 591001:ACFER_RS00565
uniprot id: D2RN87
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

591001:ACFER RS08610
gene id: 591001:ACFER_RS08610
uniprot id: D2RLU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

591001:ACFER RS01890
gene id: 591001:ACFER_RS01890
uniprot id: D2RNY7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

591001:ACFER RS08580
gene id: 591001:ACFER_RS08580
uniprot id: D2RLT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

591001:ACFER RS06895
gene id: 591001:ACFER_RS06895
uniprot id: D2RKW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

591001:ACFER RS07525
gene id: 591001:ACFER_RS07525
uniprot id: D2RL85
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

591001:ACFER RS04945
gene id: 591001:ACFER_RS04945
uniprot id: D2RJS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

591001:ACFER RS00700
gene id: 591001:ACFER_RS00700
uniprot id: D2RNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

591001:ACFER RS09270
gene id: 591001:ACFER_RS09270
uniprot id: D2RM63
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

591001:ACFER RS02395
gene id: 591001:ACFER_RS02395
uniprot id: D2RIF3
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

591001:ACFER RS02685
gene id: 591001:ACFER_RS02685
uniprot id: D2RIL0
names: Similarity
messages: Belongs to the bacterial secretin family.

591001:ACFER RS09880
gene id: 591001:ACFER_RS09880
uniprot id: D2RMH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

591001:ACFER RS02675
gene id: 591001:ACFER_RS02675
uniprot id: D2RIK8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

591001:ACFER RS03325
gene id: 591001:ACFER_RS03325
uniprot id: D2RIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

591001:ACFER RS01860
gene id: 591001:ACFER_RS01860
uniprot id: D2RNY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

591001:ACFER RS04830
gene id: 591001:ACFER_RS04830
uniprot id: D2RJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

591001:ACFER RS02195
gene id: 591001:ACFER_RS02195
uniprot id: D2RP42
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

591001:ACFER RS03275
gene id: 591001:ACFER_RS03275
uniprot id: D2RIW6
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

591001:ACFER RS10105
gene id: 591001:ACFER_RS10105
uniprot id: D2RMM3
names: Similarity
messages: Belongs to the PrpF family.

591001:ACFER RS10270
gene id: 591001:ACFER_RS10270
uniprot id: D2RMQ2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

591001:ACFER RS00090
gene id: 591001:ACFER_RS00090
uniprot id: D2RMU7
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS06665
gene id: 591001:ACFER_RS06665
uniprot id: D2RKR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

591001:ACFER RS09290
gene id: 591001:ACFER_RS09290
uniprot id: P11569
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the HgdC. Reversibly inactivated by oxidants such as 2-nitrophenol, 3-nitrophenol, 4-nitrophenol, 4-nitrobenzoate, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) and chloramphenicol. Irreversibly inactivated by oxidants such as hydroxylamine and nitrite.
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
messages: Binds 1 FMN per heterodimer.
messages: Binds 1 [4Fe-4S] cluster per heterodimer.
messages: Cytoplasm
messages: Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway (PubMed:3691501). Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)-glutaconyl-CoA (PubMed:3691501, PubMed:7398622, PubMed:7607244). The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical (PubMed:7607244). Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate (PubMed:7607244). The appropriate redox state of dehydratase HgdA-HgdB complex (CompD) is maintained by HgdC (CompA) via hydrolysis of ATP and ATP-dependent electron transfer (PubMed:7607244). Since the electron is recycled, the dehydratase is able to perform several turnovers with only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) (PubMed:7607244).
messages: The (R)-2-hydroxyglutaryl-CoA dehydratase enzyme system is a heterodimer composed of an alpha subunit (HgdA) and a beta subunit (HgdB).

591001:ACFER RS03655
gene id: 591001:ACFER_RS03655
uniprot id: D2RJ36
names: Function
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

591001:ACFER RS10165
gene id: 591001:ACFER_RS10165
uniprot id: D2RMN3
names: Subcellular Location Annotation
messages: Membrane

591001:ACFER RS07175
gene id: 591001:ACFER_RS07175
uniprot id: D2RL17
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

591001:ACFER RS06345
gene id: 591001:ACFER_RS06345
uniprot id: D2RKK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

591001:ACFER RS10050
gene id: 591001:ACFER_RS10050
uniprot id: D2RML2
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

591001:ACFER RS00860
gene id: 591001:ACFER_RS00860
uniprot id: D2RNE3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

591001:ACFER RS02510
gene id: 591001:ACFER_RS02510
uniprot id: D2RIH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

591001:ACFER RS04150
gene id: 591001:ACFER_RS04150
uniprot id: D2RJC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

591001:ACFER RS05255
gene id: 591001:ACFER_RS05255
uniprot id: D2RJY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

591001:ACFER RS06820
gene id: 591001:ACFER_RS06820
uniprot id: D2RKU8
names: Similarity
messages: Belongs to the SfsA family.

591001:ACFER RS00840
gene id: 591001:ACFER_RS00840
uniprot id: D2RND9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

591001:ACFER RS05960
gene id: 591001:ACFER_RS05960
uniprot id: D2RKC6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

591001:ACFER RS03785
gene id: 591001:ACFER_RS03785
uniprot id: D2RJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

591001:ACFER RS07060
gene id: 591001:ACFER_RS07060
uniprot id: D2RKZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

591001:ACFER RS10505
gene id: 591001:ACFER_RS10505
uniprot id: D2RMY0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.