589924:FERP RS07810
gene id: 589924:FERP_RS07810
uniprot id: D3RZ02
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS10665
gene id: 589924:FERP_RS10665
uniprot id: D3S0L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

589924:FERP RS01820
gene id: 589924:FERP_RS01820
uniprot id: D3S2K9
names: Similarity
messages: Belongs to the P(II) protein family.

589924:FERP RS05165
gene id: 589924:FERP_RS05165
uniprot id: D3RXI3
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

589924:FERP RS03680
gene id: 589924:FERP_RS03680
uniprot id: D3RWP5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

589924:FERP RS11910
gene id: 589924:FERP_RS11910
uniprot id: D3S1N4
names: Similarity
messages: Belongs to the UPF0175 family.

589924:FERP RS07890
gene id: 589924:FERP_RS07890
uniprot id: D3RZ18
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

589924:FERP RS11005
gene id: 589924:FERP_RS11005
uniprot id: D3S0T2
names: Similarity
messages: Belongs to the HsdR family.

589924:FERP RS04585
gene id: 589924:FERP_RS04585
uniprot id: D3RX71
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

589924:FERP RS04410
gene id: 589924:FERP_RS04410
uniprot id: D3RX35
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

589924:FERP RS10855
gene id: 589924:FERP_RS10855
uniprot id: D3S0Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

589924:FERP RS10150
gene id: 589924:FERP_RS10150
uniprot id: D3S095
names: Subcellular Location Annotation
messages: Cell membrane

589924:FERP RS06115
gene id: 589924:FERP_RS06115
uniprot id: D3RY22
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

589924:FERP RS00395
gene id: 589924:FERP_RS00395
uniprot id: D3S133
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01910
gene id: 589924:FERP_RS01910
uniprot id: D3S2M6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00845
gene id: 589924:FERP_RS00845
uniprot id: D3S1P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

589924:FERP RS09035
gene id: 589924:FERP_RS09035
uniprot id: D3RZN2
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

589924:FERP RS04855
gene id: 589924:FERP_RS04855
uniprot id: D3RXC4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS01510
gene id: 589924:FERP_RS01510
uniprot id: D3S2E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

589924:FERP RS06495
gene id: 589924:FERP_RS06495
uniprot id: D3RY98
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS03705
gene id: 589924:FERP_RS03705
uniprot id: D3RWQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

589924:FERP RS11165
gene id: 589924:FERP_RS11165
uniprot id: D3S0W4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS11275
gene id: 589924:FERP_RS11275
uniprot id: D3S1B1
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

589924:FERP RS10670
gene id: 589924:FERP_RS10670
uniprot id: D3S0L6
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

589924:FERP RS11870
gene id: 589924:FERP_RS11870
uniprot id: D3S1M6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

589924:FERP RS08330
gene id: 589924:FERP_RS08330
uniprot id: D3RZ97
names: Similarity
messages: Belongs to the glutamine synthetase family.

589924:FERP RS00420
gene id: 589924:FERP_RS00420
uniprot id: D3S138
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

589924:FERP RS09005
gene id: 589924:FERP_RS09005
uniprot id: D3RZM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

589924:FERP RS00145
gene id: 589924:FERP_RS00145
uniprot id: D3S0Y4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

589924:FERP RS08390
gene id: 589924:FERP_RS08390
uniprot id: D3RZA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

589924:FERP RS09690
gene id: 589924:FERP_RS09690
uniprot id: D3S002
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06345
gene id: 589924:FERP_RS06345
uniprot id: D3RY68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

589924:FERP RS03645
gene id: 589924:FERP_RS03645
uniprot id: D3RWN8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

589924:FERP RS07170
gene id: 589924:FERP_RS07170
uniprot id: D3RYM9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04445
gene id: 589924:FERP_RS04445
uniprot id: D3RX43
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

589924:FERP RS03085
gene id: 589924:FERP_RS03085
uniprot id: D3S3F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

589924:FERP RS00675
gene id: 589924:FERP_RS00675
uniprot id: D3S188
names: Similarity
messages: Belongs to the MtrH family.

589924:FERP RS05525
gene id: 589924:FERP_RS05525
uniprot id: D3RXQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

589924:FERP RS12605
gene id: 589924:FERP_RS12605
uniprot id: D3S2R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

589924:FERP RS07395
gene id: 589924:FERP_RS07395
uniprot id: D3RYS6
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS05715
gene id: 589924:FERP_RS05715
uniprot id: D3RXU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

589924:FERP RS03785
gene id: 589924:FERP_RS03785
uniprot id: D3RWR6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

589924:FERP RS09265
gene id: 589924:FERP_RS09265
uniprot id: D3RZS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

589924:FERP RS04370
gene id: 589924:FERP_RS04370
uniprot id: D3RX27
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

589924:FERP RS04740
gene id: 589924:FERP_RS04740
uniprot id: D3RXA0
names: Similarity
messages: Belongs to the DtxR/MntR family.

589924:FERP RS08585
gene id: 589924:FERP_RS08585
uniprot id: D3RZE5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

589924:FERP RS04810
gene id: 589924:FERP_RS04810
uniprot id: D3RXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

589924:FERP RS09895
gene id: 589924:FERP_RS09895
uniprot id: D3S044
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

589924:FERP RS04135
gene id: 589924:FERP_RS04135
uniprot id: D3RWY1
names: Subunit
messages: Homodimer.

589924:FERP RS07145
gene id: 589924:FERP_RS07145
uniprot id: D3RYM4
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

589924:FERP RS01815
gene id: 589924:FERP_RS01815
uniprot id: D3S2K8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

589924:FERP RS10340
gene id: 589924:FERP_RS10340
uniprot id: D3S0D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

589924:FERP RS00810
gene id: 589924:FERP_RS00810
uniprot id: D3S1P3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

589924:FERP RS01925
gene id: 589924:FERP_RS01925
uniprot id: D3S2M9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

589924:FERP RS11530
gene id: 589924:FERP_RS11530
uniprot id: D3S1G4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

589924:FERP RS03490
gene id: 589924:FERP_RS03490
uniprot id: D3RWK8
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

589924:FERP RS01890
gene id: 589924:FERP_RS01890
uniprot id: D3S2M2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

589924:FERP RS00735
gene id: 589924:FERP_RS00735
uniprot id: D3S199
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

589924:FERP RS03605
gene id: 589924:FERP_RS03605
uniprot id: D3RWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

589924:FERP RS12230
gene id: 589924:FERP_RS12230
uniprot id: D3S264
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

589924:FERP RS03415
gene id: 589924:FERP_RS03415
uniprot id: D3RWJ4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

589924:FERP RS04290
gene id: 589924:FERP_RS04290
uniprot id: D3RX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

589924:FERP RS08420
gene id: 589924:FERP_RS08420
uniprot id: D3RZB5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06210
gene id: 589924:FERP_RS06210
uniprot id: D3RY41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

589924:FERP RS06650
gene id: 589924:FERP_RS06650
uniprot id: D3RYC6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

589924:FERP RS11880
gene id: 589924:FERP_RS11880
uniprot id: D3S1M8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

589924:FERP RS01405
gene id: 589924:FERP_RS01405
uniprot id: D3S1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

589924:FERP RS05485
gene id: 589924:FERP_RS05485
uniprot id: D3RXP7
names: Similarity
messages: Belongs to the UMP kinase family.

589924:FERP RS08335
gene id: 589924:FERP_RS08335
uniprot id: D3RZ98
names: Similarity
messages: Belongs to the glutamate synthase family.

589924:FERP RS11760
gene id: 589924:FERP_RS11760
uniprot id: D3S1K5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00270
gene id: 589924:FERP_RS00270
uniprot id: D3S110
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04815
gene id: 589924:FERP_RS04815
uniprot id: D3RXB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

589924:FERP RS03615
gene id: 589924:FERP_RS03615
uniprot id: D3RWN3
names: Similarity
messages: Belongs to the archaeal-type GPI family.

589924:FERP RS01265
gene id: 589924:FERP_RS01265
uniprot id: D3S1X4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

589924:FERP RS08930
gene id: 589924:FERP_RS08930
uniprot id: D3RZL2
names: Similarity
messages: Belongs to the glutaredoxin family.

589924:FERP RS03940
gene id: 589924:FERP_RS03940
uniprot id: D3RWU3
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

589924:FERP RS11535
gene id: 589924:FERP_RS11535
uniprot id: D3S1G5
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

589924:FERP RS07555
gene id: 589924:FERP_RS07555
uniprot id: D3RYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

589924:FERP RS03875
gene id: 589924:FERP_RS03875
uniprot id: D3RWT0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

589924:FERP RS03135
gene id: 589924:FERP_RS03135
uniprot id: D3S3G6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04990
gene id: 589924:FERP_RS04990
uniprot id: D3RXE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

589924:FERP RS09490
gene id: 589924:FERP_RS09490
uniprot id: D3RZW7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

589924:FERP RS00015
gene id: 589924:FERP_RS00015
uniprot id: D3S0I1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

589924:FERP RS05695
gene id: 589924:FERP_RS05695
uniprot id: D3RXT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS04415
gene id: 589924:FERP_RS04415
uniprot id: D3RX36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

589924:FERP RS06775
gene id: 589924:FERP_RS06775
uniprot id: D3RYF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

589924:FERP RS01040
gene id: 589924:FERP_RS01040
uniprot id: D3S1T5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS04760
gene id: 589924:FERP_RS04760
uniprot id: D3RXA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

589924:FERP RS03675
gene id: 589924:FERP_RS03675
uniprot id: D3RWP4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

589924:FERP RS09505
gene id: 589924:FERP_RS09505
uniprot id: D3RZX0
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

589924:FERP RS01635
gene id: 589924:FERP_RS01635
uniprot id: D3S2H0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class II subfamily.
messages: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

589924:FERP RS06770
gene id: 589924:FERP_RS06770
uniprot id: D3RYF0
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.

589924:FERP RS00705
gene id: 589924:FERP_RS00705
uniprot id: D3S194
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

589924:FERP RS07515
gene id: 589924:FERP_RS07515
uniprot id: D3RYU9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS07910
gene id: 589924:FERP_RS07910
uniprot id: D3RZ22
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

589924:FERP RS04730
gene id: 589924:FERP_RS04730
uniprot id: D3RX98
names: Similarity
messages: Belongs to the UPF0216 family.

589924:FERP RS08235
gene id: 589924:FERP_RS08235
uniprot id: D3RZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

589924:FERP RS00540
gene id: 589924:FERP_RS00540
uniprot id: D3S162
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS09360
gene id: 589924:FERP_RS09360
uniprot id: D3RZU3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

589924:FERP RS10170
gene id: 589924:FERP_RS10170
uniprot id: D3S099
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS06305
gene id: 589924:FERP_RS06305
uniprot id: D3RY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

589924:FERP RS07090
gene id: 589924:FERP_RS07090
uniprot id: D3RYL3
names: Similarity
messages: Belongs to the intimin/invasin family.

589924:FERP RS10460
gene id: 589924:FERP_RS10460
uniprot id: D3S0F2
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

589924:FERP RS06640
gene id: 589924:FERP_RS06640
uniprot id: D3RYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

589924:FERP RS12685
gene id: 589924:FERP_RS12685
uniprot id: D3S2S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

589924:FERP RS06805
gene id: 589924:FERP_RS06805
uniprot id: D3RYF7
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS08730
gene id: 589924:FERP_RS08730
uniprot id: D3RZH3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

589924:FERP RS01885
gene id: 589924:FERP_RS01885
uniprot id: D3S2M1
names: Similarity
messages: Belongs to the HisA/HisF family.

589924:FERP RS12655
gene id: 589924:FERP_RS12655
uniprot id: D3S2S3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00370
gene id: 589924:FERP_RS00370
uniprot id: D3S129
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

589924:FERP RS08465
gene id: 589924:FERP_RS08465
uniprot id: D3RZC3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

589924:FERP RS11250
gene id: 589924:FERP_RS11250
uniprot id: D3S1A6
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

589924:FERP RS04725
gene id: 589924:FERP_RS04725
uniprot id: D3RX97
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

589924:FERP RS01835
gene id: 589924:FERP_RS01835
uniprot id: D3S2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

589924:FERP RS04130
gene id: 589924:FERP_RS04130
uniprot id: D3RWY0
names: Similarity
messages: Belongs to the UPF0146 family.

589924:FERP RS01365
gene id: 589924:FERP_RS01365
uniprot id: D3S1Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

589924:FERP RS09030
gene id: 589924:FERP_RS09030
uniprot id: D3RZN1
names: Similarity
messages: Belongs to the HypE family.

589924:FERP RS02190
gene id: 589924:FERP_RS02190
uniprot id: D3S2Y0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

589924:FERP RS04540
gene id: 589924:FERP_RS04540
uniprot id: D3RX62
names: Similarity
messages: Belongs to the UPF0175 family.

589924:FERP RS06170
gene id: 589924:FERP_RS06170
uniprot id: D3RY33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

589924:FERP RS11255
gene id: 589924:FERP_RS11255
uniprot id: D3S1A7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

589924:FERP RS05205
gene id: 589924:FERP_RS05205
uniprot id: D3RXJ1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

589924:FERP RS10200
gene id: 589924:FERP_RS10200
uniprot id: D3S0A5
names: Similarity
messages: Belongs to the class-I fumarase family.

589924:FERP RS04055
gene id: 589924:FERP_RS04055
uniprot id: D3RWW5
names: Similarity
messages: Belongs to the citrate synthase family.

589924:FERP RS08135
gene id: 589924:FERP_RS08135
uniprot id: D3RZ65
names: Similarity
messages: Belongs to the UbiD family.

589924:FERP RS08355
gene id: 589924:FERP_RS08355
uniprot id: D3RZA2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

589924:FERP RS11715
gene id: 589924:FERP_RS11715
uniprot id: D3S1J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

589924:FERP RS05790
gene id: 589924:FERP_RS05790
uniprot id: D3RXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

589924:FERP RS04170
gene id: 589924:FERP_RS04170
uniprot id: D3RWY8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

589924:FERP RS09985
gene id: 589924:FERP_RS09985
uniprot id: D3S062
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS09440
gene id: 589924:FERP_RS09440
uniprot id: D3RZV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

589924:FERP RS02780
gene id: 589924:FERP_RS02780
uniprot id: D3S395
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

589924:FERP RS04035
gene id: 589924:FERP_RS04035
uniprot id: D3RWW1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

589924:FERP RS06175
gene id: 589924:FERP_RS06175
uniprot id: D3RY34
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

589924:FERP RS08105
gene id: 589924:FERP_RS08105
uniprot id: D3RZ61
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00635
gene id: 589924:FERP_RS00635
uniprot id: D3S180
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm

589924:FERP RS07500
gene id: 589924:FERP_RS07500
uniprot id: D3RYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

589924:FERP RS03865
gene id: 589924:FERP_RS03865
uniprot id: D3RWS8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04300
gene id: 589924:FERP_RS04300
uniprot id: D3RX14
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

589924:FERP RS01920
gene id: 589924:FERP_RS01920
uniprot id: D3S2M8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS04420
gene id: 589924:FERP_RS04420
uniprot id: D3RX37
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

589924:FERP RS03655
gene id: 589924:FERP_RS03655
uniprot id: D3RWP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

589924:FERP RS11895
gene id: 589924:FERP_RS11895
uniprot id: D3S1N1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

589924:FERP RS11340
gene id: 589924:FERP_RS11340
uniprot id: D3S1C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

589924:FERP RS07690
gene id: 589924:FERP_RS07690
uniprot id: D3RYY0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

589924:FERP RS11615
gene id: 589924:FERP_RS11615
uniprot id: D3S1I1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

589924:FERP RS10180
gene id: 589924:FERP_RS10180
uniprot id: D3S0A1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

589924:FERP RS09330
gene id: 589924:FERP_RS09330
uniprot id: D3RZT9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

589924:FERP RS06370
gene id: 589924:FERP_RS06370
uniprot id: D3RY73
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

589924:FERP RS00130
gene id: 589924:FERP_RS00130
uniprot id: D3S0Y1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

589924:FERP RS03060
gene id: 589924:FERP_RS03060
uniprot id: D3S3F1
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS11260
gene id: 589924:FERP_RS11260
uniprot id: D3S1A8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

589924:FERP RS04085
gene id: 589924:FERP_RS04085
uniprot id: D3RWX1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

589924:FERP RS11750
gene id: 589924:FERP_RS11750
uniprot id: D3S1K3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS01415
gene id: 589924:FERP_RS01415
uniprot id: D3S201
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

589924:FERP RS11155
gene id: 589924:FERP_RS11155
uniprot id: D3S0W2
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

589924:FERP RS10110
gene id: 589924:FERP_RS10110
uniprot id: D3S087
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS09945
gene id: 589924:FERP_RS09945
uniprot id: D3S054
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

589924:FERP RS03740
gene id: 589924:FERP_RS03740
uniprot id: D3RWQ7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS05035
gene id: 589924:FERP_RS05035
uniprot id: D3RXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

589924:FERP RS05785
gene id: 589924:FERP_RS05785
uniprot id: D3RXV6
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS05755
gene id: 589924:FERP_RS05755
uniprot id: D3RXV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS01395
gene id: 589924:FERP_RS01395
uniprot id: D3S1Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

589924:FERP RS01825
gene id: 589924:FERP_RS01825
uniprot id: D3S2L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

589924:FERP RS03895
gene id: 589924:FERP_RS03895
uniprot id: D3RWT4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

589924:FERP RS00025
gene id: 589924:FERP_RS00025
uniprot id: D3S0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

589924:FERP RS06720
gene id: 589924:FERP_RS06720
uniprot id: D3RYE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

589924:FERP RS01595
gene id: 589924:FERP_RS01595
uniprot id: D3S2G4
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS07980
gene id: 589924:FERP_RS07980
uniprot id: D3RZ36
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

589924:FERP RS09860
gene id: 589924:FERP_RS09860
uniprot id: D3S037
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

589924:FERP RS07115
gene id: 589924:FERP_RS07115
uniprot id: D3RYL8
names: Similarity
messages: Belongs to the UPF0147 family.

589924:FERP RS07225
gene id: 589924:FERP_RS07225
uniprot id: D3RYP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

589924:FERP RS09050
gene id: 589924:FERP_RS09050
uniprot id: D3RZN5
names: Similarity
messages: Belongs to the HupF/HypC family.

589924:FERP RS07005
gene id: 589924:FERP_RS07005
uniprot id: D3RYJ7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

589924:FERP RS09915
gene id: 589924:FERP_RS09915
uniprot id: D3S048
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

589924:FERP RS05140
gene id: 589924:FERP_RS05140
uniprot id: D3RXH8
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

589924:FERP RS08675
gene id: 589924:FERP_RS08675
uniprot id: D3RZG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

589924:FERP RS03205
gene id: 589924:FERP_RS03205
uniprot id: D3S3I1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

589924:FERP RS11300
gene id: 589924:FERP_RS11300
uniprot id: D3S1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

589924:FERP RS10485
gene id: 589924:FERP_RS10485
uniprot id: D3S0F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

589924:FERP RS10195
gene id: 589924:FERP_RS10195
uniprot id: D3S0A4
names: Similarity
messages: Belongs to the class-I fumarase family.

589924:FERP RS07780
gene id: 589924:FERP_RS07780
uniprot id: D3RYZ8
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

589924:FERP RS07720
gene id: 589924:FERP_RS07720
uniprot id: D3RYY6
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS03810
gene id: 589924:FERP_RS03810
uniprot id: D3RWS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS11550
gene id: 589924:FERP_RS11550
uniprot id: D3S1G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

589924:FERP RS02105
gene id: 589924:FERP_RS02105
uniprot id: D3S2W4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

589924:FERP RS09040
gene id: 589924:FERP_RS09040
uniprot id: D3RZN3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

589924:FERP RS00685
gene id: 589924:FERP_RS00685
uniprot id: D3S190
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

589924:FERP RS11545
gene id: 589924:FERP_RS11545
uniprot id: D3S1G7
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

589924:FERP RS12715
gene id: 589924:FERP_RS12715
uniprot id: D3S2T4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

589924:FERP RS12720
gene id: 589924:FERP_RS12720
uniprot id: D3S2T5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS07150
gene id: 589924:FERP_RS07150
uniprot id: D3RYM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

589924:FERP RS05900
gene id: 589924:FERP_RS05900
uniprot id: D3RXX9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

589924:FERP RS05870
gene id: 589924:FERP_RS05870
uniprot id: D3RXX3
names: Similarity
messages: Belongs to the RuvB family.

589924:FERP RS01620
gene id: 589924:FERP_RS01620
uniprot id: D3S2G7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS06520
gene id: 589924:FERP_RS06520
uniprot id: D3RYA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

589924:FERP RS03080
gene id: 589924:FERP_RS03080
uniprot id: D3S3F5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

589924:FERP RS04365
gene id: 589924:FERP_RS04365
uniprot id: D3RX26
names: Similarity
messages: Belongs to the CutA family.

589924:FERP RS11555
gene id: 589924:FERP_RS11555
uniprot id: D3S1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

589924:FERP RS09535
gene id: 589924:FERP_RS09535
uniprot id: D3RZX6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

589924:FERP RS02880
gene id: 589924:FERP_RS02880
uniprot id: D3S3B5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS04515
gene id: 589924:FERP_RS04515
uniprot id: D3RX57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

589924:FERP RS00490
gene id: 589924:FERP_RS00490
uniprot id: D3S152
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS07440
gene id: 589924:FERP_RS07440
uniprot id: D3RYT4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

589924:FERP RS07015
gene id: 589924:FERP_RS07015
uniprot id: D3RYJ9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

589924:FERP RS08020
gene id: 589924:FERP_RS08020
uniprot id: D3RZ44
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

589924:FERP RS00010
gene id: 589924:FERP_RS00010
uniprot id: D3S0I0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

589924:FERP RS10970
gene id: 589924:FERP_RS10970
uniprot id: D3S0S5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

589924:FERP RS13125
gene id: 589924:FERP_RS13125
uniprot id: D3S1D1
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

589924:FERP RS06165
gene id: 589924:FERP_RS06165
uniprot id: D3RY32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

589924:FERP RS06470
gene id: 589924:FERP_RS06470
uniprot id: D3RY93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

589924:FERP RS01775
gene id: 589924:FERP_RS01775
uniprot id: D3S2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

589924:FERP RS01420
gene id: 589924:FERP_RS01420
uniprot id: D3S202
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

589924:FERP RS03045
gene id: 589924:FERP_RS03045
uniprot id: D3S3E8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

589924:FERP RS10095
gene id: 589924:FERP_RS10095
uniprot id: D3S084
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

589924:FERP RS08775
gene id: 589924:FERP_RS08775
uniprot id: D3RZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

589924:FERP RS04240
gene id: 589924:FERP_RS04240
uniprot id: D3RX02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

589924:FERP RS08960
gene id: 589924:FERP_RS08960
uniprot id: D3RZL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS09090
gene id: 589924:FERP_RS09090
uniprot id: D3RZP2
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

589924:FERP RS00455
gene id: 589924:FERP_RS00455
uniprot id: D3S145
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS07450
gene id: 589924:FERP_RS07450
uniprot id: D3RYT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

589924:FERP RS10600
gene id: 589924:FERP_RS10600
uniprot id: D3S0K1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

589924:FERP RS04490
gene id: 589924:FERP_RS04490
uniprot id: D3RX52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS02985
gene id: 589924:FERP_RS02985
uniprot id: D3S3D7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

589924:FERP RS03220
gene id: 589924:FERP_RS03220
uniprot id: D3S3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

589924:FERP RS12225
gene id: 589924:FERP_RS12225
uniprot id: D3S263
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS12430
gene id: 589924:FERP_RS12430
uniprot id: D3S2A2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

589924:FERP RS03690
gene id: 589924:FERP_RS03690
uniprot id: D3RWP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

589924:FERP RS03410
gene id: 589924:FERP_RS03410
uniprot id: D3RWJ3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

589924:FERP RS08570
gene id: 589924:FERP_RS08570
uniprot id: D3RZE2
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS09060
gene id: 589924:FERP_RS09060
uniprot id: D3RZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

589924:FERP RS10595
gene id: 589924:FERP_RS10595
uniprot id: D3S0H8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

589924:FERP RS11580
gene id: 589924:FERP_RS11580
uniprot id: D3S1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

589924:FERP RS10000
gene id: 589924:FERP_RS10000
uniprot id: D3S065
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

589924:FERP RS11380
gene id: 589924:FERP_RS11380
uniprot id: D3S1D4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

589924:FERP RS03025
gene id: 589924:FERP_RS03025
uniprot id: D3S3E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

589924:FERP RS11525
gene id: 589924:FERP_RS11525
uniprot id: D3S1G3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

589924:FERP RS09055
gene id: 589924:FERP_RS09055
uniprot id: D3RZN6
names: Similarity
messages: Belongs to the HypD family.

589924:FERP RS10320
gene id: 589924:FERP_RS10320
uniprot id: D3S0C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

589924:FERP RS12455
gene id: 589924:FERP_RS12455
uniprot id: D3S2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

589924:FERP RS06285
gene id: 589924:FERP_RS06285
uniprot id: D3RY56
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

589924:FERP RS13840
gene id: 589924:FERP_RS13840
uniprot id: D3RZC1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

589924:FERP RS07840
gene id: 589924:FERP_RS07840
uniprot id: D3RZ08
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS03380
gene id: 589924:FERP_RS03380
uniprot id: D3RWI7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

589924:FERP RS04825
gene id: 589924:FERP_RS04825
uniprot id: D3RXB7
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

589924:FERP RS10035
gene id: 589924:FERP_RS10035
uniprot id: D3S072
names: Similarity
messages: Belongs to the TrpF family.

589924:FERP RS01410
gene id: 589924:FERP_RS01410
uniprot id: D3S200
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

589924:FERP RS10920
gene id: 589924:FERP_RS10920
uniprot id: D3S0R5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

589924:FERP RS03930
gene id: 589924:FERP_RS03930
uniprot id: D3RWU1
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS09850
gene id: 589924:FERP_RS09850
uniprot id: D3S035
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS10140
gene id: 589924:FERP_RS10140
uniprot id: D3S093
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04025
gene id: 589924:FERP_RS04025
uniprot id: D3RWV9
names: Similarity
messages: Belongs to the aspartokinase family.

589924:FERP RS00830
gene id: 589924:FERP_RS00830
uniprot id: D3S1P6
names: Similarity
messages: Belongs to the UPF0310 family.

589924:FERP RS01940
gene id: 589924:FERP_RS01940
uniprot id: D3S2N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

589924:FERP RS05720
gene id: 589924:FERP_RS05720
uniprot id: D3RXU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS06715
gene id: 589924:FERP_RS06715
uniprot id: D3RYD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

589924:FERP RS04150
gene id: 589924:FERP_RS04150
uniprot id: D3RWY4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

589924:FERP RS01360
gene id: 589924:FERP_RS01360
uniprot id: D3S1Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

589924:FERP RS03420
gene id: 589924:FERP_RS03420
uniprot id: D3RWJ5
names: Similarity
messages: Belongs to the AAA ATPase family.

589924:FERP RS12340
gene id: 589924:FERP_RS12340
uniprot id: D3S284
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS07480
gene id: 589924:FERP_RS07480
uniprot id: D3RYU2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

589924:FERP RS00560
gene id: 589924:FERP_RS00560
uniprot id: D3S165
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS07635
gene id: 589924:FERP_RS07635
uniprot id: D3RYX0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

589924:FERP RS01830
gene id: 589924:FERP_RS01830
uniprot id: D3S2L1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

589924:FERP RS01535
gene id: 589924:FERP_RS01535
uniprot id: D3S2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

589924:FERP RS00795
gene id: 589924:FERP_RS00795
uniprot id: D3S1P0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

589924:FERP RS03485
gene id: 589924:FERP_RS03485
uniprot id: D3RWK7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-61 and Arg-64) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

589924:FERP RS00980
gene id: 589924:FERP_RS00980
uniprot id: D3S1S3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS03665
gene id: 589924:FERP_RS03665
uniprot id: D3RWP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

589924:FERP RS05775
gene id: 589924:FERP_RS05775
uniprot id: D3RXV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS06575
gene id: 589924:FERP_RS06575
uniprot id: D3RYB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

589924:FERP RS03800
gene id: 589924:FERP_RS03800
uniprot id: D3RWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS03075
gene id: 589924:FERP_RS03075
uniprot id: D3S3F4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

589924:FERP RS05770
gene id: 589924:FERP_RS05770
uniprot id: D3RXV3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS00555
gene id: 589924:FERP_RS00555
uniprot id: D3S164
names: Function
messages: Part of a potassium transport system.

589924:FERP RS02075
gene id: 589924:FERP_RS02075
uniprot id: D3S2R1
names: Function
messages: Involved in the transposition of the insertion sequence.

589924:FERP RS00135
gene id: 589924:FERP_RS00135
uniprot id: D3S0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

589924:FERP RS11670
gene id: 589924:FERP_RS11670
uniprot id: D3S1J0
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS09245
gene id: 589924:FERP_RS09245
uniprot id: D3RZS2
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

589924:FERP RS11415
gene id: 589924:FERP_RS11415
uniprot id: D3S1E1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

589924:FERP RS12495
gene id: 589924:FERP_RS12495
uniprot id: D3S2B5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

589924:FERP RS00985
gene id: 589924:FERP_RS00985
uniprot id: D3S1S4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

589924:FERP RS04225
gene id: 589924:FERP_RS04225
uniprot id: D3RWZ9
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

589924:FERP RS06730
gene id: 589924:FERP_RS06730
uniprot id: D3RYE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00150
gene id: 589924:FERP_RS00150
uniprot id: D3S0Y5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

589924:FERP RS05615
gene id: 589924:FERP_RS05615
uniprot id: D3RXS2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

589924:FERP RS11480
gene id: 589924:FERP_RS11480
uniprot id: D3S1F4
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS05530
gene id: 589924:FERP_RS05530
uniprot id: D3RXQ7
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01385
gene id: 589924:FERP_RS01385
uniprot id: D3S1Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS05145
gene id: 589924:FERP_RS05145
uniprot id: D3RXH9
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

589924:FERP RS00170
gene id: 589924:FERP_RS00170
uniprot id: D3S0Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS11520
gene id: 589924:FERP_RS11520
uniprot id: D3S1G2
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

589924:FERP RS05700
gene id: 589924:FERP_RS05700
uniprot id: D3RXT9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

589924:FERP RS07505
gene id: 589924:FERP_RS07505
uniprot id: D3RYU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

589924:FERP RS08035
gene id: 589924:FERP_RS08035
uniprot id: D3RZ48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

589924:FERP RS02960
gene id: 589924:FERP_RS02960
uniprot id: D3S3D2
names: Similarity
messages: Belongs to the UPF0212 family.

589924:FERP RS03765
gene id: 589924:FERP_RS03765
uniprot id: D3RWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

589924:FERP RS07560
gene id: 589924:FERP_RS07560
uniprot id: D3RYV7
names: Similarity
messages: Belongs to the RutC family.

589924:FERP RS10745
gene id: 589924:FERP_RS10745
uniprot id: D3S0N0
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

589924:FERP RS10010
gene id: 589924:FERP_RS10010
uniprot id: D3S067
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

589924:FERP RS00965
gene id: 589924:FERP_RS00965
uniprot id: D3S1S0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

589924:FERP RS07490
gene id: 589924:FERP_RS07490
uniprot id: D3RYU4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

589924:FERP RS04110
gene id: 589924:FERP_RS04110
uniprot id: D3RWX6
names: Similarity
messages: Belongs to the AAA ATPase family.

589924:FERP RS02920
gene id: 589924:FERP_RS02920
uniprot id: D3S3C5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

589924:FERP RS11320
gene id: 589924:FERP_RS11320
uniprot id: D3S1C1
names: Similarity
messages: Belongs to the thymidylate kinase family.

589924:FERP RS05820
gene id: 589924:FERP_RS05820
uniprot id: D3RXW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

589924:FERP RS03710
gene id: 589924:FERP_RS03710
uniprot id: D3RWQ1
names: Similarity
messages: Belongs to the pyruvate kinase family.

589924:FERP RS01530
gene id: 589924:FERP_RS01530
uniprot id: D3S2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

589924:FERP RS04555
gene id: 589924:FERP_RS04555
uniprot id: D3RX65
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

589924:FERP RS03830
gene id: 589924:FERP_RS03830
uniprot id: D3RWS3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

589924:FERP RS10070
gene id: 589924:FERP_RS10070
uniprot id: D3S079
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS11470
gene id: 589924:FERP_RS11470
uniprot id: D3S1F2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

589924:FERP RS08055
gene id: 589924:FERP_RS08055
uniprot id: D3RZ52
names: Similarity
messages: Belongs to the UPF0215 family.

589924:FERP RS10610
gene id: 589924:FERP_RS10610
uniprot id: D3S0K3
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS05810
gene id: 589924:FERP_RS05810
uniprot id: D3RXW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

589924:FERP RS05625
gene id: 589924:FERP_RS05625
uniprot id: D3RXS4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS10790
gene id: 589924:FERP_RS10790
uniprot id: D3S0N9
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01630
gene id: 589924:FERP_RS01630
uniprot id: D3S2G9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

589924:FERP RS00255
gene id: 589924:FERP_RS00255
uniprot id: D3S107
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS10655
gene id: 589924:FERP_RS10655
uniprot id: D3S0L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

589924:FERP RS00160
gene id: 589924:FERP_RS00160
uniprot id: D3S0Y7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

589924:FERP RS08005
gene id: 589924:FERP_RS08005
uniprot id: D3RZ41
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00575
gene id: 589924:FERP_RS00575
uniprot id: D3S168
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

589924:FERP RS06465
gene id: 589924:FERP_RS06465
uniprot id: D3RY92
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

589924:FERP RS06435
gene id: 589924:FERP_RS06435
uniprot id: D3RY86
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

589924:FERP RS05750
gene id: 589924:FERP_RS05750
uniprot id: D3RXU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

589924:FERP RS03600
gene id: 589924:FERP_RS03600
uniprot id: D3RWN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

589924:FERP RS09960
gene id: 589924:FERP_RS09960
uniprot id: D3S057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

589924:FERP RS06205
gene id: 589924:FERP_RS06205
uniprot id: D3RY40
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

589924:FERP RS12405
gene id: 589924:FERP_RS12405
uniprot id: D3S297
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

589924:FERP RS06630
gene id: 589924:FERP_RS06630
uniprot id: D3RYC1
names: Similarity
messages: Belongs to the MEMO1 family.

589924:FERP RS09780
gene id: 589924:FERP_RS09780
uniprot id: D3S020
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS12195
gene id: 589924:FERP_RS12195
uniprot id: D3S257
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

589924:FERP RS05760
gene id: 589924:FERP_RS05760
uniprot id: D3RXV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

589924:FERP RS12210
gene id: 589924:FERP_RS12210
uniprot id: D3S260
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

589924:FERP RS00955
gene id: 589924:FERP_RS00955
uniprot id: D3S1R8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

589924:FERP RS08910
gene id: 589924:FERP_RS08910
uniprot id: D3RZK8
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06700
gene id: 589924:FERP_RS06700
uniprot id: D3RYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

589924:FERP RS07445
gene id: 589924:FERP_RS07445
uniprot id: D3RYT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

589924:FERP RS09200
gene id: 589924:FERP_RS09200
uniprot id: D3RZR2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

589924:FERP RS08040
gene id: 589924:FERP_RS08040
uniprot id: D3RZ49
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

589924:FERP RS04795
gene id: 589924:FERP_RS04795
uniprot id: D3RXB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS05975
gene id: 589924:FERP_RS05975
uniprot id: D3RXZ4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS05620
gene id: 589924:FERP_RS05620
uniprot id: D3RXS3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

589924:FERP RS05740
gene id: 589924:FERP_RS05740
uniprot id: D3RXU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS07595
gene id: 589924:FERP_RS07595
uniprot id: D3RYW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS08880
gene id: 589924:FERP_RS08880
uniprot id: D3RZK2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

589924:FERP RS06505
gene id: 589924:FERP_RS06505
uniprot id: D3RYA0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

589924:FERP RS09255
gene id: 589924:FERP_RS09255
uniprot id: D3RZS4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

589924:FERP RS04070
gene id: 589924:FERP_RS04070
uniprot id: D3RWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

589924:FERP RS03770
gene id: 589924:FERP_RS03770
uniprot id: D3RWR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS12535
gene id: 589924:FERP_RS12535
uniprot id: D3S2C4
names: Similarity
messages: Belongs to the UPF0047 family.

589924:FERP RS10155
gene id: 589924:FERP_RS10155
uniprot id: D3S096
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

589924:FERP RS10495
gene id: 589924:FERP_RS10495
uniprot id: D3S0F9
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

589924:FERP RS07070
gene id: 589924:FERP_RS07070
uniprot id: D3RYL0
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS05840
gene id: 589924:FERP_RS05840
uniprot id: D3RXW6
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06940
gene id: 589924:FERP_RS06940
uniprot id: D3RYI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

589924:FERP RS06340
gene id: 589924:FERP_RS06340
uniprot id: D3RY67
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS04770
gene id: 589924:FERP_RS04770
uniprot id: D3RXA6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

589924:FERP RS11645
gene id: 589924:FERP_RS11645
uniprot id: D3S1I5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS10115
gene id: 589924:FERP_RS10115
uniprot id: D3S088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

589924:FERP RS01540
gene id: 589924:FERP_RS01540
uniprot id: D3S2F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

589924:FERP RS07065
gene id: 589924:FERP_RS07065
uniprot id: D3RYK9
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

589924:FERP RS06440
gene id: 589924:FERP_RS06440
uniprot id: D3RY87
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

589924:FERP RS04710
gene id: 589924:FERP_RS04710
uniprot id: D3RX95
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

589924:FERP RS07105
gene id: 589924:FERP_RS07105
uniprot id: D3RYL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

589924:FERP RS06905
gene id: 589924:FERP_RS06905
uniprot id: D3RYH7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

589924:FERP RS06855
gene id: 589924:FERP_RS06855
uniprot id: D3RYG7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

589924:FERP RS10590
gene id: 589924:FERP_RS10590
uniprot id: D3S0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS10065
gene id: 589924:FERP_RS10065
uniprot id: D3S077
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

589924:FERP RS08025
gene id: 589924:FERP_RS08025
uniprot id: D3RZ45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

589924:FERP RS06580
gene id: 589924:FERP_RS06580
uniprot id: D3RYB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
messages: Cytoplasm
messages: Homotetramer.

589924:FERP RS03095
gene id: 589924:FERP_RS03095
uniprot id: D3S3F8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

589924:FERP RS10740
gene id: 589924:FERP_RS10740
uniprot id: D3S0M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

589924:FERP RS11160
gene id: 589924:FERP_RS11160
uniprot id: D3S0W3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

589924:FERP RS02115
gene id: 589924:FERP_RS02115
uniprot id: D3S2W6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

589924:FERP RS04165
gene id: 589924:FERP_RS04165
uniprot id: D3RWY7
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

589924:FERP RS05125
gene id: 589924:FERP_RS05125
uniprot id: D3RXH5
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS05670
gene id: 589924:FERP_RS05670
uniprot id: D3RXT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS05015
gene id: 589924:FERP_RS05015
uniprot id: D3RXF2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS08945
gene id: 589924:FERP_RS08945
uniprot id: D3RZL5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS12985
gene id: 589924:FERP_RS12985
uniprot id: D3RXW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

589924:FERP RS08145
gene id: 589924:FERP_RS08145
uniprot id: D3RZ67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

589924:FERP RS03090
gene id: 589924:FERP_RS03090
uniprot id: D3S3F7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

589924:FERP RS11295
gene id: 589924:FERP_RS11295
uniprot id: D3S1B6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

589924:FERP RS09275
gene id: 589924:FERP_RS09275
uniprot id: D3RZS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

589924:FERP RS00485
gene id: 589924:FERP_RS00485
uniprot id: D3S151
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

589924:FERP RS10160
gene id: 589924:FERP_RS10160
uniprot id: D3S097
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

589924:FERP RS05580
gene id: 589924:FERP_RS05580
uniprot id: D3RXR6
names: Similarity
messages: Belongs to the BtpA family.

589924:FERP RS09605
gene id: 589924:FERP_RS09605
uniprot id: D3RZY8
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01875
gene id: 589924:FERP_RS01875
uniprot id: D3S2M0
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

589924:FERP RS12960
gene id: 589924:FERP_RS12960
uniprot id: D3RWM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

589924:FERP RS05735
gene id: 589924:FERP_RS05735
uniprot id: D3RXU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS11385
gene id: 589924:FERP_RS11385
uniprot id: D3S1D5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

589924:FERP RS04765
gene id: 589924:FERP_RS04765
uniprot id: D3RXA5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

589924:FERP RS01450
gene id: 589924:FERP_RS01450
uniprot id: D3S2D5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS06785
gene id: 589924:FERP_RS06785
uniprot id: D3RYF3
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS10750
gene id: 589924:FERP_RS10750
uniprot id: D3S0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

589924:FERP RS10055
gene id: 589924:FERP_RS10055
uniprot id: D3S075
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

589924:FERP RS05500
gene id: 589924:FERP_RS05500
uniprot id: D3RXQ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

589924:FERP RS04175
gene id: 589924:FERP_RS04175
uniprot id: D3RWY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

589924:FERP RS03610
gene id: 589924:FERP_RS03610
uniprot id: D3RWN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

589924:FERP RS04235
gene id: 589924:FERP_RS04235
uniprot id: D3RX01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS06835
gene id: 589924:FERP_RS06835
uniprot id: D3RYG2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

589924:FERP RS08625
gene id: 589924:FERP_RS08625
uniprot id: D3RZF2
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

589924:FERP RS07360
gene id: 589924:FERP_RS07360
uniprot id: D3RYR9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

589924:FERP RS07165
gene id: 589924:FERP_RS07165
uniprot id: D3RYM8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

589924:FERP RS00515
gene id: 589924:FERP_RS00515
uniprot id: D3S157
names: Similarity
messages: Belongs to the phosphohexose mutase family.

589924:FERP RS06325
gene id: 589924:FERP_RS06325
uniprot id: D3RY64
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

589924:FERP RS04295
gene id: 589924:FERP_RS04295
uniprot id: D3RX13
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

589924:FERP RS01865
gene id: 589924:FERP_RS01865
uniprot id: D3S2L8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

589924:FERP RS10635
gene id: 589924:FERP_RS10635
uniprot id: D3S0K9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

589924:FERP RS07020
gene id: 589924:FERP_RS07020
uniprot id: D3RYK0
names: Similarity
messages: Belongs to the WrbA family.

589924:FERP RS10730
gene id: 589924:FERP_RS10730
uniprot id: D3S0M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

589924:FERP RS01600
gene id: 589924:FERP_RS01600
uniprot id: D3S2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

589924:FERP RS00325
gene id: 589924:FERP_RS00325
uniprot id: D3S120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

589924:FERP RS08660
gene id: 589924:FERP_RS08660
uniprot id: D3RZF9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

589924:FERP RS10100
gene id: 589924:FERP_RS10100
uniprot id: D3S085
names: Similarity
messages: Belongs to the UPF0179 family.

589924:FERP RS00530
gene id: 589924:FERP_RS00530
uniprot id: D3S160
names: Similarity
messages: Belongs to the UPF0107 family.

589924:FERP RS07585
gene id: 589924:FERP_RS07585
uniprot id: D3RYW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

589924:FERP RS11930
gene id: 589924:FERP_RS11930
uniprot id: D3S211
names: Similarity
messages: Belongs to the UDPGP type 2 family.

589924:FERP RS03475
gene id: 589924:FERP_RS03475
uniprot id: D3RWK5
names: Similarity
messages: Belongs to the UPF0282 family.

589924:FERP RS12245
gene id: 589924:FERP_RS12245
uniprot id: D3S267
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

589924:FERP RS00690
gene id: 589924:FERP_RS00690
uniprot id: D3S191
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

589924:FERP RS11045
gene id: 589924:FERP_RS11045
uniprot id: D3S0U0
names: Similarity
messages: Belongs to the DMRL synthase family.

589924:FERP RS06500
gene id: 589924:FERP_RS06500
uniprot id: D3RY99
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

589924:FERP RS02235
gene id: 589924:FERP_RS02235
uniprot id: D3S2Y8
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00165
gene id: 589924:FERP_RS00165
uniprot id: D3S0Y8
names: Similarity
messages: Belongs to the PDCD5 family.

589924:FERP RS11270
gene id: 589924:FERP_RS11270
uniprot id: D3S1B0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS07920
gene id: 589924:FERP_RS07920
uniprot id: D3RZ24
names: Similarity
messages: Belongs to the TlyA family.

589924:FERP RS09475
gene id: 589924:FERP_RS09475
uniprot id: D3RZW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

589924:FERP RS03840
gene id: 589924:FERP_RS03840
uniprot id: D3RWS5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS11175
gene id: 589924:FERP_RS11175
uniprot id: D3S0W6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

589924:FERP RS03240
gene id: 589924:FERP_RS03240
uniprot id: D3S3I8
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

589924:FERP RS12770
gene id: 589924:FERP_RS12770
uniprot id: D3S2U4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS08140
gene id: 589924:FERP_RS08140
uniprot id: D3RZ66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

589924:FERP RS07470
gene id: 589924:FERP_RS07470
uniprot id: D3RYU0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

589924:FERP RS07550
gene id: 589924:FERP_RS07550
uniprot id: D3RYV5
names: Similarity
messages: Belongs to the acylphosphatase family.

589924:FERP RS03280
gene id: 589924:FERP_RS03280
uniprot id: D3S3J5
names: Similarity
messages: Belongs to the FTR family.

589924:FERP RS10940
gene id: 589924:FERP_RS10940
uniprot id: D3S0R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

589924:FERP RS05265
gene id: 589924:FERP_RS05265
uniprot id: D3RXK3
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

589924:FERP RS06360
gene id: 589924:FERP_RS06360
uniprot id: D3RY71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

589924:FERP RS10510
gene id: 589924:FERP_RS10510
uniprot id: D3S0G2
names: Similarity
messages: Belongs to the peptidase S8 family.

589924:FERP RS10700
gene id: 589924:FERP_RS10700
uniprot id: D3S0M2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

589924:FERP RS06980
gene id: 589924:FERP_RS06980
uniprot id: D3RYJ2
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

589924:FERP RS04050
gene id: 589924:FERP_RS04050
uniprot id: D3RWW4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS05780
gene id: 589924:FERP_RS05780
uniprot id: D3RXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

589924:FERP RS05665
gene id: 589924:FERP_RS05665
uniprot id: D3RXT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

589924:FERP RS10955
gene id: 589924:FERP_RS10955
uniprot id: D3S0S2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

589924:FERP RS12480
gene id: 589924:FERP_RS12480
uniprot id: D3S2B2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

589924:FERP RS01030
gene id: 589924:FERP_RS01030
uniprot id: D3S1T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

589924:FERP RS01515
gene id: 589924:FERP_RS01515
uniprot id: D3S2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

589924:FERP RS04045
gene id: 589924:FERP_RS04045
uniprot id: D3RWW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

589924:FERP RS01285
gene id: 589924:FERP_RS01285
uniprot id: D3S1X8
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS03055
gene id: 589924:FERP_RS03055
uniprot id: D3S3F0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

589924:FERP RS04590
gene id: 589924:FERP_RS04590
uniprot id: D3RX72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

589924:FERP RS05725
gene id: 589924:FERP_RS05725
uniprot id: D3RXU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

589924:FERP RS04785
gene id: 589924:FERP_RS04785
uniprot id: D3RXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

589924:FERP RS00155
gene id: 589924:FERP_RS00155
uniprot id: D3S0Y6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

589924:FERP RS12200
gene id: 589924:FERP_RS12200
uniprot id: D3S258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

589924:FERP RS09435
gene id: 589924:FERP_RS09435
uniprot id: D3RZV6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

589924:FERP RS00315
gene id: 589924:FERP_RS00315
uniprot id: D3S118
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS04305
gene id: 589924:FERP_RS04305
uniprot id: D3RX15
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

589924:FERP RS08875
gene id: 589924:FERP_RS08875
uniprot id: D3RZK1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

589924:FERP RS08555
gene id: 589924:FERP_RS08555
uniprot id: D3RZD9
names: Similarity
messages: Belongs to the complex I subunit 3 family.

589924:FERP RS04245
gene id: 589924:FERP_RS04245
uniprot id: D3RX03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

589924:FERP RS11200
gene id: 589924:FERP_RS11200
uniprot id: D3S0X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

589924:FERP RS05765
gene id: 589924:FERP_RS05765
uniprot id: D3RXV2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

589924:FERP RS01930
gene id: 589924:FERP_RS01930
uniprot id: D3S2N0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS09145
gene id: 589924:FERP_RS09145
uniprot id: D3RZQ2
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

589924:FERP RS04890
gene id: 589924:FERP_RS04890
uniprot id: D3RXD1
names: Similarity
messages: Belongs to the MCM family.

589924:FERP RS06710
gene id: 589924:FERP_RS06710
uniprot id: D3RYD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

589924:FERP RS09585
gene id: 589924:FERP_RS09585
uniprot id: D3RZY4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

589924:FERP RS01525
gene id: 589924:FERP_RS01525
uniprot id: D3S2F0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

589924:FERP RS07855
gene id: 589924:FERP_RS07855
uniprot id: D3RZ11
names: Subcellular Location Annotation
messages: Cell membrane

589924:FERP RS04505
gene id: 589924:FERP_RS04505
uniprot id: D3RX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

589924:FERP RS07465
gene id: 589924:FERP_RS07465
uniprot id: D3RYT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

589924:FERP RS05420
gene id: 589924:FERP_RS05420
uniprot id: D3RXN4
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01570
gene id: 589924:FERP_RS01570
uniprot id: D3S2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

589924:FERP RS10475
gene id: 589924:FERP_RS10475
uniprot id: D3S0F5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

589924:FERP RS05345
gene id: 589924:FERP_RS05345
uniprot id: D3RXL9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

589924:FERP RS06120
gene id: 589924:FERP_RS06120
uniprot id: D3RY23
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS10560
gene id: 589924:FERP_RS10560
uniprot id: D3S0H1
names: Similarity
messages: Belongs to the AOR/FOR family.

589924:FERP RS00935
gene id: 589924:FERP_RS00935
uniprot id: D3S1R4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

589924:FERP RS07195
gene id: 589924:FERP_RS07195
uniprot id: D3RYN4
names: Similarity
messages: Belongs to the peptidase M20A family.

589924:FERP RS11865
gene id: 589924:FERP_RS11865
uniprot id: D3S1M5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS01625
gene id: 589924:FERP_RS01625
uniprot id: D3S2G8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

589924:FERP RS11325
gene id: 589924:FERP_RS11325
uniprot id: D3S1C2
names: Subunit
messages: Homotetramer.

589924:FERP RS10680
gene id: 589924:FERP_RS10680
uniprot id: D3S0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

589924:FERP RS03550
gene id: 589924:FERP_RS03550
uniprot id: D3RWM0
names: Similarity
messages: Belongs to the acylphosphatase family.

589924:FERP RS06955
gene id: 589924:FERP_RS06955
uniprot id: D3RYI7
names: Similarity
messages: Belongs to the ZPR1 family.

589924:FERP RS11875
gene id: 589924:FERP_RS11875
uniprot id: D3S1M7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

589924:FERP RS04440
gene id: 589924:FERP_RS04440
uniprot id: D3RX42
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

589924:FERP RS04275
gene id: 589924:FERP_RS04275
uniprot id: D3RX09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

589924:FERP RS04975
gene id: 589924:FERP_RS04975
uniprot id: D3RXE4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

589924:FERP RS08185
gene id: 589924:FERP_RS08185
uniprot id: D3RZ75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

589924:FERP RS05685
gene id: 589924:FERP_RS05685
uniprot id: D3RXT6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

589924:FERP RS11145
gene id: 589924:FERP_RS11145
uniprot id: D3S0W0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

589924:FERP RS04230
gene id: 589924:FERP_RS04230
uniprot id: D3RX00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS05085
gene id: 589924:FERP_RS05085
uniprot id: D3RXG7
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT(+).

589924:FERP RS10025
gene id: 589924:FERP_RS10025
uniprot id: D3S070
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

589924:FERP RS07600
gene id: 589924:FERP_RS07600
uniprot id: D3RYW5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

589924:FERP RS05300
gene id: 589924:FERP_RS05300
uniprot id: D3RXL0
names: Similarity
messages: Belongs to the UPF0175 family.

589924:FERP RS04375
gene id: 589924:FERP_RS04375
uniprot id: D3RX28
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

589924:FERP RS11125
gene id: 589924:FERP_RS11125
uniprot id: D3S0V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

589924:FERP RS00250
gene id: 589924:FERP_RS00250
uniprot id: D3S106
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS12850
gene id: 589924:FERP_RS12850
uniprot id: D3S2W0
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

589924:FERP RS05160
gene id: 589924:FERP_RS05160
uniprot id: D3RXI2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

589924:FERP RS11170
gene id: 589924:FERP_RS11170
uniprot id: D3S0W5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

589924:FERP RS01860
gene id: 589924:FERP_RS01860
uniprot id: D3S2L7
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00700
gene id: 589924:FERP_RS00700
uniprot id: D3S193
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS05405
gene id: 589924:FERP_RS05405
uniprot id: D3RXN1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

589924:FERP RS09840
gene id: 589924:FERP_RS09840
uniprot id: D3S033
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

589924:FERP RS00475
gene id: 589924:FERP_RS00475
uniprot id: D3S149
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS09965
gene id: 589924:FERP_RS09965
uniprot id: D3S058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

589924:FERP RS07340
gene id: 589924:FERP_RS07340
uniprot id: D3RYR4
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

589924:FERP RS07220
gene id: 589924:FERP_RS07220
uniprot id: D3RYN9
names: Subcellular Location Annotation
messages: Cell membrane

589924:FERP RS06740
gene id: 589924:FERP_RS06740
uniprot id: D3RYE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

589924:FERP RS03805
gene id: 589924:FERP_RS03805
uniprot id: D3RWS0
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

589924:FERP RS12420
gene id: 589924:FERP_RS12420
uniprot id: D3S2A0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS05225
gene id: 589924:FERP_RS05225
uniprot id: D3RXJ5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS12355
gene id: 589924:FERP_RS12355
uniprot id: D3S287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

589924:FERP RS11825
gene id: 589924:FERP_RS11825
uniprot id: D3S1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

589924:FERP RS01245
gene id: 589924:FERP_RS01245
uniprot id: D3S1X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

589924:FERP RS07645
gene id: 589924:FERP_RS07645
uniprot id: D3RYX2
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06080
gene id: 589924:FERP_RS06080
uniprot id: D3RY16
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

589924:FERP RS10995
gene id: 589924:FERP_RS10995
uniprot id: D3S0T0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

589924:FERP RS08885
gene id: 589924:FERP_RS08885
uniprot id: D3RZK3
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS03305
gene id: 589924:FERP_RS03305
uniprot id: D3S3K2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

589924:FERP RS07175
gene id: 589924:FERP_RS07175
uniprot id: D3RYN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

589924:FERP RS01545
gene id: 589924:FERP_RS01545
uniprot id: D3S2F4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

589924:FERP RS03495
gene id: 589924:FERP_RS03495
uniprot id: D3RWK9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

589924:FERP RS06660
gene id: 589924:FERP_RS06660
uniprot id: D3RYC8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

589924:FERP RS10020
gene id: 589924:FERP_RS10020
uniprot id: D3S069
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS08955
gene id: 589924:FERP_RS08955
uniprot id: D3RZL7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

589924:FERP RS11345
gene id: 589924:FERP_RS11345
uniprot id: D3S1C7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

589924:FERP RS03670
gene id: 589924:FERP_RS03670
uniprot id: D3RWP3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

589924:FERP RS09720
gene id: 589924:FERP_RS09720
uniprot id: D3S008
names: Subcellular Location Annotation
messages: Cell membrane

589924:FERP RS09930
gene id: 589924:FERP_RS09930
uniprot id: D3S051
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.

589924:FERP RS01555
gene id: 589924:FERP_RS01555
uniprot id: D3S2F6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS07475
gene id: 589924:FERP_RS07475
uniprot id: D3RYU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS11265
gene id: 589924:FERP_RS11265
uniprot id: D3S1A9
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

589924:FERP RS01035
gene id: 589924:FERP_RS01035
uniprot id: D3S1T4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

589924:FERP RS10535
gene id: 589924:FERP_RS10535
uniprot id: D3S0G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

589924:FERP RS04075
gene id: 589924:FERP_RS04075
uniprot id: D3RWW9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

589924:FERP RS05520
gene id: 589924:FERP_RS05520
uniprot id: D3RXQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

589924:FERP RS10710
gene id: 589924:FERP_RS10710
uniprot id: D3S0M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

589924:FERP RS12140
gene id: 589924:FERP_RS12140
uniprot id: D3S246
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

589924:FERP RS04310
gene id: 589924:FERP_RS04310
uniprot id: D3RX16
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

589924:FERP RS12155
gene id: 589924:FERP_RS12155
uniprot id: D3S249
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

589924:FERP RS03795
gene id: 589924:FERP_RS03795
uniprot id: D3RWR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS01750
gene id: 589924:FERP_RS01750
uniprot id: D3S2J6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

589924:FERP RS09125
gene id: 589924:FERP_RS09125
uniprot id: D3RZP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

589924:FERP RS02995
gene id: 589924:FERP_RS02995
uniprot id: D3S3D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

589924:FERP RS10480
gene id: 589924:FERP_RS10480
uniprot id: D3S0F6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

589924:FERP RS10045
gene id: 589924:FERP_RS10045
uniprot id: D3S074
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

589924:FERP RS08265
gene id: 589924:FERP_RS08265
uniprot id: D3RZ87
names: Similarity
messages: Belongs to the UPF0175 family.

589924:FERP RS09320
gene id: 589924:FERP_RS09320
uniprot id: D3RZT7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

589924:FERP RS07605
gene id: 589924:FERP_RS07605
uniprot id: D3RYW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

589924:FERP RS04875
gene id: 589924:FERP_RS04875
uniprot id: D3RXC8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

589924:FERP RS04060
gene id: 589924:FERP_RS04060
uniprot id: D3RWW6
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

589924:FERP RS11135
gene id: 589924:FERP_RS11135
uniprot id: D3S0V8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

589924:FERP RS12690
gene id: 589924:FERP_RS12690
uniprot id: D3S2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

589924:FERP RS07010
gene id: 589924:FERP_RS07010
uniprot id: D3RYJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

589924:FERP RS09970
gene id: 589924:FERP_RS09970
uniprot id: D3S059
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS04845
gene id: 589924:FERP_RS04845
uniprot id: D3RXC1
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS10085
gene id: 589924:FERP_RS10085
uniprot id: D3S082
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

589924:FERP RS11915
gene id: 589924:FERP_RS11915
uniprot id: D3S208
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

589924:FERP RS09765
gene id: 589924:FERP_RS09765
uniprot id: D3S017
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

589924:FERP RS05115
gene id: 589924:FERP_RS05115
uniprot id: D3RXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

589924:FERP RS01990
gene id: 589924:FERP_RS01990
uniprot id: D3S2P2
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS09865
gene id: 589924:FERP_RS09865
uniprot id: D3S038
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

589924:FERP RS12515
gene id: 589924:FERP_RS12515
uniprot id: D3S2C0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

589924:FERP RS09135
gene id: 589924:FERP_RS09135
uniprot id: D3RZQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

589924:FERP RS05430
gene id: 589924:FERP_RS05430
uniprot id: D3RXN6
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS06365
gene id: 589924:FERP_RS06365
uniprot id: D3RY72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

589924:FERP RS07125
gene id: 589924:FERP_RS07125
uniprot id: D3RYM0
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00840
gene id: 589924:FERP_RS00840
uniprot id: D3S1P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

589924:FERP RS08115
gene id: 589924:FERP_RS08115
uniprot id: D3RZ64
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS10785
gene id: 589924:FERP_RS10785
uniprot id: D3S0N8
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS01255
gene id: 589924:FERP_RS01255
uniprot id: D3S1X2
names: Similarity
messages: Belongs to the arsA ATPase family.

589924:FERP RS04860
gene id: 589924:FERP_RS04860
uniprot id: D3RXC5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

589924:FERP RS03885
gene id: 589924:FERP_RS03885
uniprot id: D3RWT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS08065
gene id: 589924:FERP_RS08065
uniprot id: D3RZ54
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

589924:FERP RS00715
gene id: 589924:FERP_RS00715
uniprot id: D3S196
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

589924:FERP RS10400
gene id: 589924:FERP_RS10400
uniprot id: D3S0E0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

589924:FERP RS08635
gene id: 589924:FERP_RS08635
uniprot id: D3RZF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

589924:FERP RS05610
gene id: 589924:FERP_RS05610
uniprot id: D3RXS1
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS10505
gene id: 589924:FERP_RS10505
uniprot id: D3S0G1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS11150
gene id: 589924:FERP_RS11150
uniprot id: D3S0W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

589924:FERP RS09510
gene id: 589924:FERP_RS09510
uniprot id: D3RZX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

589924:FERP RS11350
gene id: 589924:FERP_RS11350
uniprot id: D3S1C8
names: Function
messages: Probably involved in the biogenesis of the ribosome.

589924:FERP RS09085
gene id: 589924:FERP_RS09085
uniprot id: D3RZP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

589924:FERP RS07365
gene id: 589924:FERP_RS07365
uniprot id: D3RYS0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

589924:FERP RS05710
gene id: 589924:FERP_RS05710
uniprot id: D3RXU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS04630
gene id: 589924:FERP_RS04630
uniprot id: D3RX80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

589924:FERP RS01130
gene id: 589924:FERP_RS01130
uniprot id: D3S1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

589924:FERP RS11430
gene id: 589924:FERP_RS11430
uniprot id: D3S1E4
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

589924:FERP RS10585
gene id: 589924:FERP_RS10585
uniprot id: D3S0H6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

589924:FERP RS08765
gene id: 589924:FERP_RS08765
uniprot id: D3RZI0
names: Similarity
messages: Belongs to the MtrH family.

589924:FERP RS10465
gene id: 589924:FERP_RS10465
uniprot id: D3S0F3
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS08095
gene id: 589924:FERP_RS08095
uniprot id: D3RZ59
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

589924:FERP RS02955
gene id: 589924:FERP_RS02955
uniprot id: D3S3D1
names: Similarity
messages: Belongs to the HerA family.

589924:FERP RS08545
gene id: 589924:FERP_RS08545
uniprot id: D3RZD7
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS07805
gene id: 589924:FERP_RS07805
uniprot id: D3RZ01
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

589924:FERP RS05120
gene id: 589924:FERP_RS05120
uniprot id: D3RXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

589924:FERP RS01225
gene id: 589924:FERP_RS01225
uniprot id: D3S1W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

589924:FERP RS06725
gene id: 589924:FERP_RS06725
uniprot id: D3RYE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

589924:FERP RS00470
gene id: 589924:FERP_RS00470
uniprot id: D3S148
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

589924:FERP RS08160
gene id: 589924:FERP_RS08160
uniprot id: D3RZ70
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

589924:FERP RS02900
gene id: 589924:FERP_RS02900
uniprot id: D3S3C0
names: Similarity
messages: Belongs to the glutaredoxin family.

589924:FERP RS00970
gene id: 589924:FERP_RS00970
uniprot id: D3S1S1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

589924:FERP RS11720
gene id: 589924:FERP_RS11720
uniprot id: D3S1J7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

589924:FERP RS01755
gene id: 589924:FERP_RS01755
uniprot id: D3S2J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

589924:FERP RS00570
gene id: 589924:FERP_RS00570
uniprot id: D3S167
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

589924:FERP RS05680
gene id: 589924:FERP_RS05680
uniprot id: D3RXT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

589924:FERP RS11450
gene id: 589924:FERP_RS11450
uniprot id: D3S1E8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

589924:FERP RS01270
gene id: 589924:FERP_RS01270
uniprot id: D3S1X5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

589924:FERP RS06995
gene id: 589924:FERP_RS06995
uniprot id: D3RYJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

589924:FERP RS05655
gene id: 589924:FERP_RS05655
uniprot id: D3RXT0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

589924:FERP RS10125
gene id: 589924:FERP_RS10125
uniprot id: D3S090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

589924:FERP RS08110
gene id: 589924:FERP_RS08110
uniprot id: D3RZ63
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

589924:FERP RS10860
gene id: 589924:FERP_RS10860
uniprot id: D3S0Q3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

589924:FERP RS06685
gene id: 589924:FERP_RS06685
uniprot id: D3RYD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

589924:FERP RS06680
gene id: 589924:FERP_RS06680
uniprot id: D3RYD2
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS05255
gene id: 589924:FERP_RS05255
uniprot id: D3RXK1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

589924:FERP RS10575
gene id: 589924:FERP_RS10575
uniprot id: D3S0H4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS08630
gene id: 589924:FERP_RS08630
uniprot id: D3RZF3
names: Similarity
messages: Belongs to the UPF0047 family.

589924:FERP RS08860
gene id: 589924:FERP_RS08860
uniprot id: D3RZJ8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

589924:FERP RS09940
gene id: 589924:FERP_RS09940
uniprot id: D3S053
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

589924:FERP RS09180
gene id: 589924:FERP_RS09180
uniprot id: D3RZQ9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

589924:FERP RS09105
gene id: 589924:FERP_RS09105
uniprot id: D3RZP5
names: Similarity
messages: Belongs to the peptidase U62 family.

589924:FERP RS04400
gene id: 589924:FERP_RS04400
uniprot id: D3RX33
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

589924:FERP RS07875
gene id: 589924:FERP_RS07875
uniprot id: D3RZ15
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

589924:FERP RS08690
gene id: 589924:FERP_RS08690
uniprot id: D3RZG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00590
gene id: 589924:FERP_RS00590
uniprot id: D3S171
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00785
gene id: 589924:FERP_RS00785
uniprot id: D3S1N8
names: Similarity
messages: Belongs to the SUI1 family.

589924:FERP RS01230
gene id: 589924:FERP_RS01230
uniprot id: D3S1W7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

589924:FERP RS04560
gene id: 589924:FERP_RS04560
uniprot id: D3RX66
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

589924:FERP RS05690
gene id: 589924:FERP_RS05690
uniprot id: D3RXT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

589924:FERP RS05130
gene id: 589924:FERP_RS05130
uniprot id: D3RXH6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

589924:FERP RS06280
gene id: 589924:FERP_RS06280
uniprot id: D3RY55
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

589924:FERP RS12545
gene id: 589924:FERP_RS12545
uniprot id: D3S2C6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

589924:FERP RS10190
gene id: 589924:FERP_RS10190
uniprot id: D3S0A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

589924:FERP RS09755
gene id: 589924:FERP_RS09755
uniprot id: D3S015
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

589924:FERP RS06400
gene id: 589924:FERP_RS06400
uniprot id: D3RY79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

589924:FERP RS01080
gene id: 589924:FERP_RS01080
uniprot id: D3S1U3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

589924:FERP RS05460
gene id: 589924:FERP_RS05460
uniprot id: D3RXP2
names: Similarity
messages: Belongs to the UPF0248 family.

589924:FERP RS00585
gene id: 589924:FERP_RS00585
uniprot id: D3S170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

589924:FERP RS04595
gene id: 589924:FERP_RS04595
uniprot id: D3RX73
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS03575
gene id: 589924:FERP_RS03575
uniprot id: D3RWM5
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS12265
gene id: 589924:FERP_RS12265
uniprot id: D3S271
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS00670
gene id: 589924:FERP_RS00670
uniprot id: D3S187
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

589924:FERP RS09160
gene id: 589924:FERP_RS09160
uniprot id: D3RZQ5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

589924:FERP RS08970
gene id: 589924:FERP_RS08970
uniprot id: D3RZM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

589924:FERP RS10685
gene id: 589924:FERP_RS10685
uniprot id: D3S0L9
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

589924:FERP RS08590
gene id: 589924:FERP_RS08590
uniprot id: D3RZE6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

589924:FERP RS08165
gene id: 589924:FERP_RS08165
uniprot id: D3RZ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

589924:FERP RS10810
gene id: 589924:FERP_RS10810
uniprot id: D3S0P3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS00390
gene id: 589924:FERP_RS00390
uniprot id: D3S132
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS08415
gene id: 589924:FERP_RS08415
uniprot id: D3RZB4
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS12595
gene id: 589924:FERP_RS12595
uniprot id: D3S2R4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

589924:FERP RS09845
gene id: 589924:FERP_RS09845
uniprot id: D3S034
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

589924:FERP RS01380
gene id: 589924:FERP_RS01380
uniprot id: D3S1Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

589924:FERP RS05135
gene id: 589924:FERP_RS05135
uniprot id: D3RXH7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

589924:FERP RS07825
gene id: 589924:FERP_RS07825
uniprot id: D3RZ05
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS03790
gene id: 589924:FERP_RS03790
uniprot id: D3RWR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

589924:FERP RS06865
gene id: 589924:FERP_RS06865
uniprot id: D3RYG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

589924:FERP RS09015
gene id: 589924:FERP_RS09015
uniprot id: D3RZM8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

589924:FERP RS09465
gene id: 589924:FERP_RS09465
uniprot id: D3RZW2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS11850
gene id: 589924:FERP_RS11850
uniprot id: D3S1M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

589924:FERP RS08740
gene id: 589924:FERP_RS08740
uniprot id: D3RZH5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

589924:FERP RS00140
gene id: 589924:FERP_RS00140
uniprot id: D3S0Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

589924:FERP RS06485
gene id: 589924:FERP_RS06485
uniprot id: D3RY96
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Belongs to the UPF0201 family.

589924:FERP RS01895
gene id: 589924:FERP_RS01895
uniprot id: D3S2M3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

589924:FERP RS03775
gene id: 589924:FERP_RS03775
uniprot id: D3RWR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

589924:FERP RS09810
gene id: 589924:FERP_RS09810
uniprot id: D3S027
names: Similarity
messages: Belongs to the UPF0280 family.

589924:FERP RS03900
gene id: 589924:FERP_RS03900
uniprot id: D3RWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

589924:FERP RS10845
gene id: 589924:FERP_RS10845
uniprot id: D3S0Q0
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

589924:FERP RS03890
gene id: 589924:FERP_RS03890
uniprot id: D3RWT3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

589924:FERP RS06515
gene id: 589924:FERP_RS06515
uniprot id: D3RYA2
names: Similarity
messages: Belongs to the MoaB/Mog family.

589924:FERP RS01500
gene id: 589924:FERP_RS01500
uniprot id: D3S2E5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

589924:FERP RS01845
gene id: 589924:FERP_RS01845
uniprot id: D3S2L4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

589924:FERP RS04405
gene id: 589924:FERP_RS04405
uniprot id: D3RX34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

589924:FERP RS01520
gene id: 589924:FERP_RS01520
uniprot id: D3S2E9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

589924:FERP RS11755
gene id: 589924:FERP_RS11755
uniprot id: D3S1K4
names: Similarity
messages: Belongs to the UPF0045 family.

589924:FERP RS06880
gene id: 589924:FERP_RS06880
uniprot id: D3RYH2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS12470
gene id: 589924:FERP_RS12470
uniprot id: D3S2B0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

589924:FERP RS05360
gene id: 589924:FERP_RS05360
uniprot id: D3RXM2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

589924:FERP RS06690
gene id: 589924:FERP_RS06690
uniprot id: D3RYD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

589924:FERP RS03915
gene id: 589924:FERP_RS03915
uniprot id: D3RWT8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

589924:FERP RS05470
gene id: 589924:FERP_RS05470
uniprot id: D3RXP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

589924:FERP RS08845
gene id: 589924:FERP_RS08845
uniprot id: D3RZJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

589924:FERP RS01955
gene id: 589924:FERP_RS01955
uniprot id: D3S2N5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS07845
gene id: 589924:FERP_RS07845
uniprot id: D3RZ09
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

589924:FERP RS00850
gene id: 589924:FERP_RS00850
uniprot id: D3S1Q0
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

589924:FERP RS05260
gene id: 589924:FERP_RS05260
uniprot id: D3RXK2
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

589924:FERP RS05020
gene id: 589924:FERP_RS05020
uniprot id: D3RXF3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

589924:FERP RS08305
gene id: 589924:FERP_RS08305
uniprot id: D3RZ92
names: Similarity
messages: Belongs to the phosphoribulokinase family.

589924:FERP RS09365
gene id: 589924:FERP_RS09365
uniprot id: D3RZU4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

589924:FERP RS07280
gene id: 589924:FERP_RS07280
uniprot id: D3RYQ1
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS05445
gene id: 589924:FERP_RS05445
uniprot id: D3RXN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

589924:FERP RS08870
gene id: 589924:FERP_RS08870
uniprot id: D3RZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

589924:FERP RS01460
gene id: 589924:FERP_RS01460
uniprot id: D3S2D7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

589924:FERP RS11185
gene id: 589924:FERP_RS11185
uniprot id: D3S0W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

589924:FERP RS10080
gene id: 589924:FERP_RS10080
uniprot id: D3S081
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

589924:FERP RS03460
gene id: 589924:FERP_RS03460
uniprot id: D3RWK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

589924:FERP RS08100
gene id: 589924:FERP_RS08100
uniprot id: D3RZ60
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

589924:FERP RS09250
gene id: 589924:FERP_RS09250
uniprot id: D3RZS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

589924:FERP RS01580
gene id: 589924:FERP_RS01580
uniprot id: D3S2G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

589924:FERP RS10805
gene id: 589924:FERP_RS10805
uniprot id: D3S0P2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

589924:FERP RS01550
gene id: 589924:FERP_RS01550
uniprot id: D3S2F5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

589924:FERP RS12380
gene id: 589924:FERP_RS12380
uniprot id: D3S292
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

589924:FERP RS12475
gene id: 589924:FERP_RS12475
uniprot id: D3S2B1
names: Similarity
messages: Belongs to the peptidase M24B family.

589924:FERP RS12205
gene id: 589924:FERP_RS12205
uniprot id: D3S259
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

589924:FERP RS06780
gene id: 589924:FERP_RS06780
uniprot id: D3RYF2
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.

589924:FERP RS00605
gene id: 589924:FERP_RS00605
uniprot id: D3S174
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

589924:FERP RS05675
gene id: 589924:FERP_RS05675
uniprot id: D3RXT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

589924:FERP RS00995
gene id: 589924:FERP_RS00995
uniprot id: D3S1S6
names: Subcellular Location Annotation
messages: Membrane

589924:FERP RS12385
gene id: 589924:FERP_RS12385
uniprot id: D3S293
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

589924:FERP RS11585
gene id: 589924:FERP_RS11585
uniprot id: D3S1H6
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

589924:FERP RS05795
gene id: 589924:FERP_RS05795
uniprot id: D3RXV8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

589924:FERP RS05055
gene id: 589924:FERP_RS05055
uniprot id: D3RXG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

589924:FERP RS08195
gene id: 589924:FERP_RS08195
uniprot id: D3RZ77
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

589924:FERP RS11540
gene id: 589924:FERP_RS11540
uniprot id: D3S1G6
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

589924:FERP RS04315
gene id: 589924:FERP_RS04315
uniprot id: D3RX17
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

589924:FERP RS01250
gene id: 589924:FERP_RS01250
uniprot id: D3S1X1
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

589924:FERP RS10455
gene id: 589924:FERP_RS10455
uniprot id: D3S0F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

589924:FERP RS11085
gene id: 589924:FERP_RS11085
uniprot id: D3S0U8
names: Similarity
messages: Belongs to the threonine synthase family.

589924:FERP RS03760
gene id: 589924:FERP_RS03760
uniprot id: D3RWR1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

589924:FERP RS01240
gene id: 589924:FERP_RS01240
uniprot id: D3S1W9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

589924:FERP RS03780
gene id: 589924:FERP_RS03780
uniprot id: D3RWR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

589924:FERP RS12885
gene id: 589924:FERP_RS12885
uniprot id: D3S1V9
names: Similarity
messages: Belongs to the peptidase S8 family.

589924:FERP RS12180
gene id: 589924:FERP_RS12180
uniprot id: D3S254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

589924:FERP RS09925
gene id: 589924:FERP_RS09925
uniprot id: D3S050
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

589924:FERP RS08735
gene id: 589924:FERP_RS08735
uniprot id: D3RZH4
names: Similarity
messages: Belongs to the peptidase C56 family.

589924:FERP RS00550
gene id: 589924:FERP_RS00550
uniprot id: D3S163
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

589924:FERP RS10040
gene id: 589924:FERP_RS10040
uniprot id: D3S073
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

589924:FERP RS08700
gene id: 589924:FERP_RS08700
uniprot id: D3RZG7
names: Similarity
messages: Belongs to the UPF0284 family.

589924:FERP RS10910
gene id: 589924:FERP_RS10910
uniprot id: D3S0R3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

589924:FERP RS03650
gene id: 589924:FERP_RS03650
uniprot id: D3RWN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.