5874:TA08895
gene id: 5874:TA08895
uniprot id: Q4U9E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

5874:TA10275
gene id: 5874:TA10275
uniprot id: Q4U8W1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

5874:TA19690
gene id: 5874:TA19690
uniprot id: Q4UGK1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

5874:TA07050
gene id: 5874:TA07050
uniprot id: Q4UAM2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA11510
gene id: 5874:TA11510
uniprot id: Q4UDI9
names: Similarity
messages: Belongs to the DDI1 family.

5874:TA11150
gene id: 5874:TA11150
uniprot id: Q4U8I0
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

5874:TA04910
gene id: 5874:TA04910
uniprot id: Q4UBS9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.

5874:TA12105
gene id: 5874:TA12105
uniprot id: Q4UDU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

5874:TA12660
gene id: 5874:TA12660
uniprot id: Q4UE48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

5874:TA10840
gene id: 5874:TA10840
uniprot id: Q4U964
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

5874:TA08375
gene id: 5874:TA08375
uniprot id: Q4U9N8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA05985
gene id: 5874:TA05985
uniprot id: Q4UI36
names: Similarity
messages: Belongs to the mTERF family.

5874:TA07605
gene id: 5874:TA07605
uniprot id: Q4UA29
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

5874:TA09695
gene id: 5874:TA09695
uniprot id: Q4UJ49
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

5874:TA11110
gene id: 5874:TA11110
uniprot id: Q4U8H2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

5874:TA08450
gene id: 5874:TA08450
uniprot id: Q4U9M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

5874:TA11700
gene id: 5874:TA11700
uniprot id: Q4UDM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

5874:TA14260
gene id: 5874:TA14260
uniprot id: Q4UEY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

5874:TA06705
gene id: 5874:TA06705
uniprot id: Q4UHR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

5874:TA16620
gene id: 5874:TA16620
uniprot id: Q4UIZ7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA09885
gene id: 5874:TA09885
uniprot id: Q4U8P0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

5874:TA03450
gene id: 5874:TA03450
uniprot id: Q4UCK7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

5874:TA15185
gene id: 5874:TA15185
uniprot id: Q4UFD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

5874:TA11065
gene id: 5874:TA11065
uniprot id: Q4U8G3
names: Similarity
messages: Belongs to the amidase family.

5874:TA10875
gene id: 5874:TA10875
uniprot id: Q4U969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

5874:TA07425
gene id: 5874:TA07425
uniprot id: Q4UA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

5874:TA17970
gene id: 5874:TA17970
uniprot id: Q4UB55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA17310
gene id: 5874:TA17310
uniprot id: Q4UAN5
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

5874:TA20935
gene id: 5874:TA20935
uniprot id: Q4UGW8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA08710
gene id: 5874:TA08710
uniprot id: Q4U9H6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

5874:TA05125
gene id: 5874:TA05125
uniprot id: Q4UBP0
names: Subcellular Location Annotation
messages: Membrane

5874:TA09000
gene id: 5874:TA09000
uniprot id: Q4U9C6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

5874:TA05660
gene id: 5874:TA05660
uniprot id: Q4UHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

5874:TA13050
gene id: 5874:TA13050
uniprot id: Q4UEB8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA21010
gene id: 5874:TA21010
uniprot id: Q4UGV4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA10140
gene id: 5874:TA10140
uniprot id: Q4U8T6
names: Similarity
messages: Belongs to the DCP1 family.

5874:TA07490
gene id: 5874:TA07490
uniprot id: Q4UA49
names: Similarity
messages: Belongs to the RRN3 family.

5874:TA20380
gene id: 5874:TA20380
uniprot id: Q4UH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

5874:TA11330
gene id: 5874:TA11330
uniprot id: Q4U8L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
messages: nucleolus

5874:TA14730
gene id: 5874:TA14730
uniprot id: Q4UDE5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

5874:TA11745
gene id: 5874:TA11745
uniprot id: Q4UDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

5874:TA15600
gene id: 5874:TA15600
uniprot id: Q4UFK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

5874:TA07510
gene id: 5874:TA07510
uniprot id: Q4UA46
names: Similarity
messages: Belongs to the CAF1 family.

5874:TA13735
gene id: 5874:TA13735
uniprot id: Q4UDC6
names: Similarity
messages: Belongs to the PPase family.

5874:TA12120
gene id: 5874:TA12120
uniprot id: Q4UDV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA15770
gene id: 5874:TA15770
uniprot id: Q4UDG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

5874:TA06760
gene id: 5874:TA06760
uniprot id: Q4UHS3
names: Subcellular Location Annotation
messages: Membrane

5874:TA07335
gene id: 5874:TA07335
uniprot id: Q4UA78
names: Subcellular Location Annotation
messages: Nucleus

5874:TA05485
gene id: 5874:TA05485
uniprot id: Q4UCQ7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).

5874:TA17715
gene id: 5874:TA17715
uniprot id: Q4UB99
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

5874:TA09930
gene id: 5874:TA09930
uniprot id: Q4U8P8
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA20710
gene id: 5874:TA20710
uniprot id: Q4UH15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

5874:TA12240
gene id: 5874:TA12240
uniprot id: Q4UDX3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

5874:TA18090
gene id: 5874:TA18090
uniprot id: Q4UB33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

5874:TA06055
gene id: 5874:TA06055
uniprot id: Q4UI50
names: Similarity
messages: Belongs to the UQCRB/QCR7 family.

5874:TA12330
gene id: 5874:TA12330
uniprot id: Q4UDY7
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA07740
gene id: 5874:TA07740
uniprot id: Q4UA03
names: Similarity
messages: Belongs to the Nudix hydrolase family.

5874:TA09205
gene id: 5874:TA09205
uniprot id: Q4UAG6
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.

5874:TA07860
gene id: 5874:TA07860
uniprot id: Q4U9Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

5874:TA10060
gene id: 5874:TA10060
uniprot id: Q4U8S2
names: Similarity
messages: Belongs to the WD repeat coronin family.

5874:TA16995
gene id: 5874:TA16995
uniprot id: Q4UIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

5874:TA07100
gene id: 5874:TA07100
uniprot id: Q4UAC2
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03895
gene id: 5874:TA03895
uniprot id: Q4UCC5
names: Similarity
messages: Belongs to the protein kinase superfamily.

5874:TA21245
gene id: 5874:TA21245
uniprot id: Q4UGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRQ/QCR8 family.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA05765
gene id: 5874:TA05765
uniprot id: Q4UHZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

5874:TA04510
gene id: 5874:TA04510
uniprot id: Q4UC11
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

5874:TA17425
gene id: 5874:TA17425
uniprot id: Q4UAV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

5874:TA06290
gene id: 5874:TA06290
uniprot id: Q4UI92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

5874:TA10315
gene id: 5874:TA10315
uniprot id: Q4U8W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

5874:TA14600
gene id: 5874:TA14600
uniprot id: Q4UF48
names: Similarity
messages: Belongs to the adenylate kinase family.

5874:TA21450
gene id: 5874:TA21450
uniprot id: Q4UGL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

5874:TA15840
gene id: 5874:TA15840
uniprot id: Q4UFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

5874:TA07710
gene id: 5874:TA07710
uniprot id: Q4UA08
names: Similarity
messages: Belongs to the CCDC124 family.

5874:TA15890
gene id: 5874:TA15890
uniprot id: Q4UFQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

5874:TA17400
gene id: 5874:TA17400
uniprot id: Q4UAU6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

5874:TA05500
gene id: 5874:TA05500
uniprot id: Q4UCQ4
names: Similarity
messages: Belongs to the CAP family.

5874:TA17710
gene id: 5874:TA17710
uniprot id: Q4UBA0
names: Similarity
messages: Belongs to the PAF1 family.

5874:TA13200
gene id: 5874:TA13200
uniprot id: Q4UEE5
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

5874:TA09555
gene id: 5874:TA09555
uniprot id: Q4UJ22
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA13500
gene id: 5874:TA13500
uniprot id: Q4UEK0
names: Similarity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.

5874:TA09395
gene id: 5874:TA09395
uniprot id: Q4UAC8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

5874:TA20965
gene id: 5874:TA20965
uniprot id: Q4UGW3
names: Subcellular Location Annotation
messages: Membrane

5874:TA03235
gene id: 5874:TA03235
uniprot id: Q4UCP5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

5874:TA15855
gene id: 5874:TA15855
uniprot id: Q4UFQ4
names: Similarity
messages: Belongs to the synaptobrevin family.

5874:TA06850
gene id: 5874:TA06850
uniprot id: Q4UHU1
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

5874:TA11075
gene id: 5874:TA11075
uniprot id: Q4U8G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

5874:TA17290
gene id: 5874:TA17290
uniprot id: Q4UAN9
names: Similarity
messages: Belongs to the SNF8 family.

5874:TA19430
gene id: 5874:TA19430
uniprot id: Q4UGF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

5874:TA14300
gene id: 5874:TA14300
uniprot id: Q4UEZ4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

5874:TA16275
gene id: 5874:TA16275
uniprot id: Q4UIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA06440
gene id: 5874:TA06440
uniprot id: Q4UIB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

5874:TA20585
gene id: 5874:TA20585
uniprot id: Q4UH40
names: Similarity
messages: Belongs to the RNR ribonuclease family.

5874:TA19090
gene id: 5874:TA19090
uniprot id: Q4UG97
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA21365
gene id: 5874:TA21365
uniprot id: Q4UGN4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

5874:TA07465
gene id: 5874:TA07465
uniprot id: Q4UA54
names: Similarity
messages: Belongs to the EF-Ts family.

5874:TA04017
gene id: 5874:TA04017
uniprot id: Q4UCA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA18290
gene id: 5874:TA18290
uniprot id: Q4UAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

5874:TA13790
gene id: 5874:TA13790
uniprot id: Q4UEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

5874:TA18035
gene id: 5874:TA18035
uniprot id: Q4UB42
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

5874:TA10800
gene id: 5874:TA10800
uniprot id: Q4U956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

5874:TA08755
gene id: 5874:TA08755
uniprot id: Q4U9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

5874:TA15910
gene id: 5874:TA15910
uniprot id: Q4UFR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA12325
gene id: 5874:TA12325
uniprot id: Q4UDY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

5874:TA18615
gene id: 5874:TA18615
uniprot id: Q4UBG5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

5874:TA12425
gene id: 5874:TA12425
uniprot id: Q4UE04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA09100
gene id: 5874:TA09100
uniprot id: Q4U9A7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

5874:TA04765
gene id: 5874:TA04765
uniprot id: Q4UBV5
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA06695
gene id: 5874:TA06695
uniprot id: Q4UHR0
names: Similarity
messages: Belongs to the MCM family.

5874:TA07295
gene id: 5874:TA07295
uniprot id: Q4UA86
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

5874:TA20460
gene id: 5874:TA20460
uniprot id: Q4UH65
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA13520
gene id: 5874:TA13520
uniprot id: Q4UEK4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA08350
gene id: 5874:TA08350
uniprot id: Q4U9P3
names: Similarity
messages: Belongs to the PPP phosphatase family. BSU subfamily.

5874:TA16610
gene id: 5874:TA16610
uniprot id: Q4UIZ5
names: Similarity
messages: Belongs to the peptidase M18 family.

5874:TA04520
gene id: 5874:TA04520
uniprot id: Q4UC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA07265
gene id: 5874:TA07265
uniprot id: Q4UA90
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

5874:TA10290
gene id: 5874:TA10290
uniprot id: Q4U8W4
names: Subcellular Location Annotation
messages: Nucleus

5874:TA20065
gene id: 5874:TA20065
uniprot id: Q4UG58
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

5874:TA13185
gene id: 5874:TA13185
uniprot id: Q94770
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA19810
gene id: 5874:TA19810
uniprot id: Q4UG08
names: Similarity
messages: Belongs to the hexokinase family.

5874:TA07320
gene id: 5874:TA07320
uniprot id: Q4UA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

5874:TA14895
gene id: 5874:TA14895
uniprot id: Q4UDE8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

5874:TA19790
gene id: 5874:TA19790
uniprot id: Q4UG04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

5874:TA09605
gene id: 5874:TA09605
uniprot id: Q4UJ31
names: Similarity
messages: Belongs to the PRP18 family.

5874:TA12945
gene id: 5874:TA12945
uniprot id: Q4UE99
names: Subcellular Location Annotation
messages: Membrane

5874:TA06565
gene id: 5874:TA06565
uniprot id: Q4UIE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.
messages: Nucleus

5874:TA13125
gene id: 5874:TA13125
uniprot id: Q4UED3
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

5874:TA19475
gene id: 5874:TA19475
uniprot id: Q4UGG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA11250
gene id: 5874:TA11250
uniprot id: Q4U8K0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

5874:TA07400
gene id: 5874:TA07400
uniprot id: Q4UA66
names: Similarity
messages: Belongs to the bystin family.

5874:TA11540
gene id: 5874:TA11540
uniprot id: Q4UDJ5
names: Similarity
messages: Belongs to the pyruvate kinase family.

5874:TA10595
gene id: 5874:TA10595
uniprot id: Q4U918
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

5874:TA10110
gene id: 5874:TA10110
uniprot id: Q4U8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

5874:TA02700
gene id: 5874:TA02700
uniprot id: Q4UD43
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

5874:TA16840
gene id: 5874:TA16840
uniprot id: Q4UIK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

5874:TA11585
gene id: 5874:TA11585
uniprot id: Q4UDK4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

5874:TA21300
gene id: 5874:TA21300
uniprot id: Q4UGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

5874:TA20415
gene id: 5874:TA20415
uniprot id: Q4UH74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA10710
gene id: 5874:TA10710
uniprot id: Q4U940
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

5874:TA04210
gene id: 5874:TA04210
uniprot id: Q4UC65
names: Similarity
messages: Belongs to the TFIIB family.

5874:TA14820
gene id: 5874:TA14820
uniprot id: Q4UF88
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

5874:TA03075
gene id: 5874:TA03075
uniprot id: Q4UHG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

5874:TA14510
gene id: 5874:TA14510
uniprot id: Q4UDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus

5874:TA17730
gene id: 5874:TA17730
uniprot id: Q4UB97
names: Similarity
messages: Belongs to the V-ATPase G subunit family.

5874:TA10690
gene id: 5874:TA10690
uniprot id: Q4U8F2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA12420
gene id: 5874:TA12420
uniprot id: Q4UDA3
names: Similarity
messages: Belongs to the yippee family.

5874:TA12030
gene id: 5874:TA12030
uniprot id: Q4UDT4
names: Subcellular Location Annotation
messages: Nucleus

5874:TA11145
gene id: 5874:TA11145
uniprot id: Q4U8H9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA05070
gene id: 5874:TA05070
uniprot id: Q4UBQ0
names: Similarity
messages: Belongs to the peptidase S14 family.

5874:TA11685
gene id: 5874:TA11685
uniprot id: Q4UDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

5874:TA15215
gene id: 5874:TA15215
uniprot id: Q4UFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

5874:TA03055
gene id: 5874:TA03055
uniprot id: Q4UHG4
names: Similarity
messages: Belongs to the adenylate kinase family.

5874:TA10185
gene id: 5874:TA10185
uniprot id: Q4U8U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

5874:TA09705
gene id: 5874:TA09705
uniprot id: Q4UJ51
names: Similarity
messages: Belongs to the DeSI family.

5874:TA06015
gene id: 5874:TA06015
uniprot id: Q4UI42
names: Similarity
messages: Belongs to the eIF-2-alpha family.

5874:TA04185
gene id: 5874:TA04185
uniprot id: Q4UC69
names: Similarity
messages: Belongs to the PITHD1 family.

5874:TA20900
gene id: 5874:TA20900
uniprot id: Q4UGX5
names: Similarity
messages: Belongs to the ANP32 family.

5874:TA07595
gene id: 5874:TA07595
uniprot id: Q4UA31
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

5874:TA10545
gene id: 5874:TA10545
uniprot id: Q4U907
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA19355
gene id: 5874:TA19355
uniprot id: Q4UGE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Cytoplasm

5874:TA15275
gene id: 5874:TA15275
uniprot id: Q4UDF4
names: Similarity
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Part of the nascent polypeptide-associated complex (NAC).

5874:TA03755
gene id: 5874:TA03755
uniprot id: Q4UCF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: extracellular matrix

5874:TA18565
gene id: 5874:TA18565
uniprot id: Q4UBH5
names: Subcellular Location Annotation
messages: nucleolus

5874:TA06885
gene id: 5874:TA06885
uniprot id: Q4UHU8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA11470
gene id: 5874:TA11470
uniprot id: Q4UDI3
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

5874:TA20885
gene id: 5874:TA20885
uniprot id: Q4UGX8
names: Subcellular Location Annotation
messages: Membrane

5874:TA14785
gene id: 5874:TA14785
uniprot id: Q4UDE6
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA11565
gene id: 5874:TA11565
uniprot id: Q4UDK0
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA12860
gene id: 5874:TA12860
uniprot id: Q4UE84
names: Similarity
messages: Belongs to the protein kinase superfamily.

5874:TA18515
gene id: 5874:TA18515
uniprot id: Q4UBI5
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA17300
gene id: 5874:TA17300
uniprot id: Q4UAN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

5874:TA18940
gene id: 5874:TA18940
uniprot id: Q4UG70
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

5874:TA10085
gene id: 5874:TA10085
uniprot id: Q4U8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Membrane

5874:TA20270
gene id: 5874:TA20270
uniprot id: Q4UHA3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

5874:TA21040
gene id: 5874:TA21040
uniprot id: Q4UGU8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

5874:TA15220
gene id: 5874:TA15220
uniprot id: Q4UDF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

5874:TA03050
gene id: 5874:TA03050
uniprot id: Q4UHG5
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

5874:TA05130
gene id: 5874:TA05130
uniprot id: Q4UBN9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03730
gene id: 5874:TA03730
uniprot id: Q4UCF5
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA04615
gene id: 5874:TA04615
uniprot id: Q4UBZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

5874:TA04160
gene id: 5874:TA04160
uniprot id: Q4UC74
names: Similarity
messages: Belongs to the NAD kinase family.

5874:TA04665
gene id: 5874:TA04665
uniprot id: Q4UBY3
names: Similarity
messages: Belongs to the CHFR family.

5874:TA05925
gene id: 5874:TA05925
uniprot id: Q4UHP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

5874:TA16615
gene id: 5874:TA16615
uniprot id: Q4UIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

5874:TA18320
gene id: 5874:TA18320
uniprot id: Q4UAZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA10195
gene id: 5874:TA10195
uniprot id: Q4U8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

5874:TA10760
gene id: 5874:TA10760
uniprot id: Q4U948
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

5874:TA04885
gene id: 5874:TA04885
uniprot id: Q4UBT4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA04630
gene id: 5874:TA04630
uniprot id: Q4UBY8
names: Similarity
messages: Belongs to the CACTIN family.

5874:TA11715
gene id: 5874:TA11715
uniprot id: Q4UDM6
names: Similarity
messages: Belongs to the exportin family.

5874:TA14850
gene id: 5874:TA14850
uniprot id: Q4UF94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

5874:TA13680
gene id: 5874:TA13680
uniprot id: Q4UEN3
names: Similarity
messages: Belongs to the MCM family.

5874:TA08160
gene id: 5874:TA08160
uniprot id: Q4U9S7
names: Similarity
messages: Belongs to the syntaxin family.

5874:TA05750
gene id: 5874:TA05750
uniprot id: Q4UHZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

5874:TA16585
gene id: 5874:TA16585
uniprot id: Q4UIZ0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA12345
gene id: 5874:TA12345
uniprot id: Q4UDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA12280
gene id: 5874:TA12280
uniprot id: Q4UDY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

5874:TA04525
gene id: 5874:TA04525
uniprot id: Q4UC08
names: Similarity
messages: Belongs to the activator 1 small subunits family.

5874:TA07790
gene id: 5874:TA07790
uniprot id: Q4U9Z6
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

5874:TA07620
gene id: 5874:TA07620
uniprot id: Q4UA26
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

5874:TA13560
gene id: 5874:TA13560
uniprot id: Q4UEL2
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

5874:TA05685
gene id: 5874:TA05685
uniprot id: Q4UHY2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA18370
gene id: 5874:TA18370
uniprot id: Q4UAX9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA14960
gene id: 5874:TA14960
uniprot id: Q4UFV6
names: Subcellular Location Annotation
messages: nucleolus

5874:TA08295
gene id: 5874:TA08295
uniprot id: Q4U9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

5874:TA20125
gene id: 5874:TA20125
uniprot id: Q4UHD1
names: Similarity
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

5874:TA17995
gene id: 5874:TA17995
uniprot id: Q4UB50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

5874:TA08665
gene id: 5874:TA08665
uniprot id: Q4U9I5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

5874:TA15040
gene id: 5874:TA15040
uniprot id: Q4UFU7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA04000
gene id: 5874:TA04000
uniprot id: Q4UCA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA16730
gene id: 5874:TA16730
uniprot id: Q4UII4
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

5874:TA12535
gene id: 5874:TA12535
uniprot id: Q4UE25
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

5874:TA21225
gene id: 5874:TA21225
uniprot id: Q4UGR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

5874:TA05785
gene id: 5874:TA05785
uniprot id: Q4UI00
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

5874:TA16360
gene id: 5874:TA16360
uniprot id: Q4UIV0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

5874:TA19860
gene id: 5874:TA19860
uniprot id: Q4UG17
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA07900
gene id: 5874:TA07900
uniprot id: Q4U9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

5874:TA10945
gene id: 5874:TA10945
uniprot id: Q4U983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCR10/QCR9 family.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA14920
gene id: 5874:TA14920
uniprot id: Q4UFA6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

5874:TA09855
gene id: 5874:TA09855
uniprot id: Q4U8N5
names: Subcellular Location Annotation
messages: nucleolus

5874:TA17065
gene id: 5874:TA17065
uniprot id: Q4UIQ1
names: Similarity
messages: Belongs to the CEF1 family.

5874:TA06605
gene id: 5874:TA06605
uniprot id: Q4UIF0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

5874:TA03740
gene id: 5874:TA03740
uniprot id: P25781
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA12540
gene id: 5874:TA12540
uniprot id: Q4UE26
names: Similarity
messages: Belongs to the syntaxin family.

5874:TA18560
gene id: 5874:TA18560
uniprot id: Q4UBH6
names: Similarity
messages: Belongs to the CWC15 family.

5874:TA16000
gene id: 5874:TA16000
uniprot id: Q4UFS9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

5874:TA07170
gene id: 5874:TA07170
uniprot id: Q4UAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF-assemblin family.
messages: cytoskeleton

5874:TA06295
gene id: 5874:TA06295
uniprot id: Q4UI93
names: Similarity
messages: Belongs to the NOC2 family.

5874:TA14775
gene id: 5874:TA14775
uniprot id: Q4UF80
names: Similarity
messages: Belongs to the FGGY kinase family.

5874:TA04440
gene id: 5874:TA04440
uniprot id: Q4UC24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

5874:TA09535
gene id: 5874:TA09535
uniprot id: Q4UJ18
names: Subcellular Location Annotation
messages: Nucleus

5874:TA16165
gene id: 5874:TA16165
uniprot id: Q4UIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit.

5874:TA10280
gene id: 5874:TA10280
uniprot id: Q4U8W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

5874:TA08590
gene id: 5874:TA08590
uniprot id: Q4U9J9
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

5874:TA09220
gene id: 5874:TA09220
uniprot id: Q4UAG3
names: Similarity
messages: Belongs to the protein kinase superfamily.

5874:TA16545
gene id: 5874:TA16545
uniprot id: Q4UIY4
names: Similarity
messages: Belongs to the acylphosphatase family.

5874:TA09120
gene id: 5874:TA09120
uniprot id: Q4U9A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAP2/GCS1 family.
messages: Cell membrane
messages: Membrane

5874:TA08320
gene id: 5874:TA08320
uniprot id: Q4U9P8
names: Similarity
messages: Belongs to the RNase Z family.

5874:TA06205
gene id: 5874:TA06205
uniprot id: Q4UI77
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

5874:TA09005
gene id: 5874:TA09005
uniprot id: Q4U9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA08800
gene id: 5874:TA08800
uniprot id: Q4U9G0
names: Similarity
messages: Belongs to the MCM family.

5874:TA04950
gene id: 5874:TA04950
uniprot id: Q4UBS2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA16520
gene id: 5874:TA16520
uniprot id: Q4UIX9
names: Similarity
messages: Belongs to the UFD1 family.

5874:TA17870
gene id: 5874:TA17870
uniprot id: Q4UB72
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

5874:TA07680
gene id: 5874:TA07680
uniprot id: Q4UA14
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

5874:TA16670
gene id: 5874:TA16670
uniprot id: Q4UJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA13000
gene id: 5874:TA13000
uniprot id: Q4UEA9
names: Similarity
messages: Belongs to the AHA1 family.

5874:TA07530
gene id: 5874:TA07530
uniprot id: Q4UA42
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

5874:TA11365
gene id: 5874:TA11365
uniprot id: Q4U8M3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

5874:TA20700
gene id: 5874:TA20700
uniprot id: Q4UH17
names: Similarity
messages: Belongs to the dopey family.

5874:TA08020
gene id: 5874:TA08020
uniprot id: Q4U9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

5874:TA12805
gene id: 5874:TA12805
uniprot id: Q4UDB0
names: Similarity
messages: Belongs to the PPP phosphatase family.

5874:TA16475
gene id: 5874:TA16475
uniprot id: Q4UIX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

5874:TA08390
gene id: 5874:TA08390
uniprot id: Q4UAJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

5874:TA04645
gene id: 5874:TA04645
uniprot id: Q4UCW3
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

5874:TA20525
gene id: 5874:TA20525
uniprot id: Q4UH52
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

5874:TA19350
gene id: 5874:TA19350
uniprot id: Q4UGE1
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

5874:TA17900
gene id: 5874:TA17900
uniprot id: Q4UB67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

5874:TA14825
gene id: 5874:TA14825
uniprot id: Q4UF89
names: Subcellular Location Annotation
messages: Membrane

5874:TA12310
gene id: 5874:TA12310
uniprot id: Q4UDA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

5874:TA19405
gene id: 5874:TA19405
uniprot id: Q4UGF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

5874:TA15640
gene id: 5874:TA15640
uniprot id: Q4UFL5
names: Similarity
messages: Belongs to the CWC26 family.

5874:TA04035
gene id: 5874:TA04035
uniprot id: Q4UC96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA05875
gene id: 5874:TA05875
uniprot id: Q4UI16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

5874:TA07960
gene id: 5874:TA07960
uniprot id: Q4U9W4
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

5874:TA13530
gene id: 5874:TA13530
uniprot id: Q4UEK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

5874:TA12690
gene id: 5874:TA12690
uniprot id: Q4UDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

5874:TA19130
gene id: 5874:TA19130
uniprot id: Q4UGA3
names: Similarity
messages: Belongs to the peptidase M16 family.

5874:TA07270
gene id: 5874:TA07270
uniprot id: Q4UA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0235 family.
messages: Membrane

5874:TA13895
gene id: 5874:TA13895
uniprot id: Q4UES3
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.

5874:TA17380
gene id: 5874:TA17380
uniprot id: Q4UAU2
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

5874:TA19955
gene id: 5874:TA19955
uniprot id: Q4UG36
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA12930
gene id: 5874:TA12930
uniprot id: Q4UE96
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

5874:TA16975
gene id: 5874:TA16975
uniprot id: Q4UIN3
names: Similarity
messages: Belongs to the peptidase S14 family.

5874:TA19765
gene id: 5874:TA19765
uniprot id: Q4UFZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

5874:TA07975
gene id: 5874:TA07975
uniprot id: Q4U9W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

5874:TA15865
gene id: 5874:TA15865
uniprot id: Q4UFQ6
names: Cofactor
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.

5874:TA13850
gene id: 5874:TA13850
uniprot id: Q4UER4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the profilin family.
messages: Binds actin.
messages: Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton.
messages: cytoskeleton

5874:TA08725
gene id: 5874:TA08725
uniprot id: Q4U9H5
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA13725
gene id: 5874:TA13725
uniprot id: Q4UEP2
names: Subcellular Location Annotation
messages: Nucleus

5874:TA09190
gene id: 5874:TA09190
uniprot id: Q4UAG9
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.

5874:TA08145
gene id: 5874:TA08145
uniprot id: Q4U9T0
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

5874:TA03565
gene id: 5874:TA03565
uniprot id: Q4UCI4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA14495
gene id: 5874:TA14495
uniprot id: Q4UF30
names: Subcellular Location Annotation
messages: Membrane

5874:TA09350
gene id: 5874:TA09350
uniprot id: Q4UAD7
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

5874:TA21000
gene id: 5874:TA21000
uniprot id: Q4UGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

5874:TA20510
gene id: 5874:TA20510
uniprot id: Q4UH55
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA10385
gene id: 5874:TA10385
uniprot id: Q4U8Y0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

5874:TA05100
gene id: 5874:TA05100
uniprot id: Q4UBP5
names: Subcellular Location Annotation
messages: Membrane

5874:TA11140
gene id: 5874:TA11140
uniprot id: Q4U8H8
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

5874:TA14290
gene id: 5874:TA14290
uniprot id: Q4UDD7
names: Similarity
messages: Belongs to the DXR family.

5874:TA04760
gene id: 5874:TA04760
uniprot id: Q4UBV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

5874:TA09165
gene id: 5874:TA09165
uniprot id: Q4UAH4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

5874:TA04370
gene id: 5874:TA04370
uniprot id: Q4UC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

5874:TA07280
gene id: 5874:TA07280
uniprot id: Q4UA87
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA12680
gene id: 5874:TA12680
uniprot id: Q4UE52
names: Similarity
messages: Belongs to the PPP phosphatase family.

5874:TA02555
gene id: 5874:TA02555
uniprot id: Q4UD14
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

5874:TA18265
gene id: 5874:TA18265
uniprot id: Q4UB00
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

5874:TA20265
gene id: 5874:TA20265
uniprot id: Q4UHA4
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

5874:TA03335
gene id: 5874:TA03335
uniprot id: Q4UCM7
names: Subcellular Location Annotation
messages: Nucleus

5874:TA17890
gene id: 5874:TA17890
uniprot id: Q4UB69
names: Similarity
messages: Belongs to the Rab GDI family.

5874:TA04045
gene id: 5874:TA04045
uniprot id: Q4UC94
names: Similarity
messages: Belongs to the GPI family.

5874:TA03980
gene id: 5874:TA03980
uniprot id: Q4UCA9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA12835
gene id: 5874:TA12835
uniprot id: Q4UE79
names: Subcellular Location Annotation
messages: Nucleus

5874:TA20850
gene id: 5874:TA20850
uniprot id: Q4UGY5
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

5874:TA16315
gene id: 5874:TA16315
uniprot id: Q4UIU2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA19740
gene id: 5874:TA19740
uniprot id: Q4UFZ4
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

5874:TA18230
gene id: 5874:TA18230
uniprot id: Q4UB07
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

5874:TA15750
gene id: 5874:TA15750
uniprot id: Q4UFN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Cytoplasm

5874:TA18050
gene id: 5874:TA18050
uniprot id: Q4UBK0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

5874:TA14965
gene id: 5874:TA14965
uniprot id: Q4UFV7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

5874:TA13460
gene id: 5874:TA13460
uniprot id: Q4UEJ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

5874:TA12570
gene id: 5874:TA12570
uniprot id: Q4UE32
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

5874:TA13100
gene id: 5874:TA13100
uniprot id: Q4UEC8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

5874:TA16350
gene id: 5874:TA16350
uniprot id: Q4UIH2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

5874:TA18485
gene id: 5874:TA18485
uniprot id: Q4UBJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

5874:TA21430
gene id: 5874:TA21430
uniprot id: Q4UGM1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

5874:TA08215
gene id: 5874:TA08215
uniprot id: Q4U9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA17635
gene id: 5874:TA17635
uniprot id: Q4UBB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Membrane

5874:TA05055
gene id: 5874:TA05055
uniprot id: Q4UBQ3
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03350
gene id: 5874:TA03350
uniprot id: Q4UCM4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

5874:TA14185
gene id: 5874:TA14185
uniprot id: Q4UEX3
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA16455
gene id: 5874:TA16455
uniprot id: Q4UIW7
names: Similarity
messages: Belongs to the VPS16 family.

5874:TA10200
gene id: 5874:TA10200
uniprot id: Q4U8E4
names: Similarity
messages: Belongs to the NSRP1 family.

5874:TA17455
gene id: 5874:TA17455
uniprot id: Q4UAV7
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

5874:TA04725
gene id: 5874:TA04725
uniprot id: Q4UBW3
names: Similarity
messages: Belongs to the NEMF family.

5874:TA04018
gene id: 5874:TA04018
uniprot id: Q4UCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA19310
gene id: 5874:TA19310
uniprot id: Q4UGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Cytoplasm

5874:TA08925
gene id: 5874:TA08925
uniprot id: Q4U9D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

5874:TA02825
gene id: 5874:TA02825
uniprot id: Q4UHK9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

5874:TA17980
gene id: 5874:TA17980
uniprot id: Q4UB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

5874:TA02615
gene id: 5874:TA02615
uniprot id: Q4UD26
names: Subcellular Location Annotation
messages: Nucleus

5874:TA17020
gene id: 5874:TA17020
uniprot id: Q4UIP2
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

5874:TA06130
gene id: 5874:TA06130
uniprot id: Q4UI64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

5874:TA12735
gene id: 5874:TA12735
uniprot id: Q4UE61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

5874:TA17725
gene id: 5874:TA17725
uniprot id: Q4UB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

5874:TA12180
gene id: 5874:TA12180
uniprot id: Q4UDW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

5874:TA15425
gene id: 5874:TA15425
uniprot id: Q4UFH6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

5874:TA18735
gene id: 5874:TA18735
uniprot id: Q4UBE1
names: Similarity
messages: Belongs to the UFL1 family.

5874:TA20520
gene id: 5874:TA20520
uniprot id: Q4UH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

5874:TA13580
gene id: 5874:TA13580
uniprot id: Q4UEL4
names: Similarity
messages: Belongs to the Deltex family.

5874:TA04955
gene id: 5874:TA04955
uniprot id: Q4UBS1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

5874:TA04175
gene id: 5874:TA04175
uniprot id: Q4UC71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA04016
gene id: 5874:TA04016
uniprot id: Q4UCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA15980
gene id: 5874:TA15980
uniprot id: Q4UFS7
names: Similarity
messages: Belongs to the phosducin family.

5874:TA06450
gene id: 5874:TA06450
uniprot id: Q4UIC1
names: Similarity
messages: Belongs to the ATPase delta chain family.

5874:TA11350
gene id: 5874:TA11350
uniprot id: Q4U8M0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA20820
gene id: 5874:TA20820
uniprot id: Q4UGZ1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

5874:TA13905
gene id: 5874:TA13905
uniprot id: Q4UES4
names: Subcellular Location Annotation
messages: Membrane

5874:TA03620
gene id: 5874:TA03620
uniprot id: Q4UCH4
names: Similarity
messages: Belongs to the nuclease type I family.

5874:TA08070
gene id: 5874:TA08070
uniprot id: Q4U9U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA03445
gene id: 5874:TA03445
uniprot id: Q4UCK8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

5874:TA09310
gene id: 5874:TA09310
uniprot id: Q4UAE5
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA16510
gene id: 5874:TA16510
uniprot id: Q4UIX7
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

5874:TA18700
gene id: 5874:TA18700
uniprot id: Q4UBE8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA04010
gene id: 5874:TA04010
uniprot id: Q4UCA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA12745
gene id: 5874:TA12745
uniprot id: Q4UE63
names: Similarity
messages: Belongs to the peptidase S16 family.

5874:TA07639
gene id: 5874:TA07639
uniprot id: Q4UA22
names: Subcellular Location Annotation
messages: nucleolus

5874:TA15105
gene id: 5874:TA15105
uniprot id: Q4UFB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA17805
gene id: 5874:TA17805
uniprot id: Q4UB84
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

5874:TA19340
gene id: 5874:TA19340
uniprot id: Q4UGD9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA10835
gene id: 5874:TA10835
uniprot id: Q4U963
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

5874:TA04865
gene id: 5874:TA04865
uniprot id: Q4UBT8
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

5874:TA08700
gene id: 5874:TA08700
uniprot id: Q4U9H8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA11275
gene id: 5874:TA11275
uniprot id: Q4U8K5
names: Similarity
messages: Belongs to the Iojap/RsfS family.

5874:TA19240
gene id: 5874:TA19240
uniprot id: Q4UGC3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

5874:TA08435
gene id: 5874:TA08435
uniprot id: Q4U9M7
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

5874:TA17735
gene id: 5874:TA17735
uniprot id: Q4UB96
names: Similarity
messages: Belongs to the VPS52 family.

5874:TA16725
gene id: 5874:TA16725
uniprot id: Q4UII3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

5874:TA08560
gene id: 5874:TA08560
uniprot id: Q4U9K5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA03505
gene id: 5874:TA03505
uniprot id: Q4UCJ6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

5874:TA04145
gene id: 5874:TA04145
uniprot id: Q4UCX3
names: Subcellular Location Annotation
messages: Nucleus

5874:TA09580
gene id: 5874:TA09580
uniprot id: Q4UJ27
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

5874:TA03930
gene id: 5874:TA03930
uniprot id: Q4UCX6
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

5874:TA08080
gene id: 5874:TA08080
uniprot id: Q4U9U3
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

5874:TA06860
gene id: 5874:TA06860
uniprot id: Q4UHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

5874:TA05610
gene id: 5874:TA05610
uniprot id: Q4UHM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

5874:TA21270
gene id: 5874:TA21270
uniprot id: Q4UGQ3
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

5874:TA03590
gene id: 5874:TA03590
uniprot id: Q4UCH9
names: Subcellular Location Annotation
messages: Membrane

5874:TA11370
gene id: 5874:TA11370
uniprot id: Q4U8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB4 family.
messages: Nucleus

5874:TA16260
gene id: 5874:TA16260
uniprot id: Q4UIT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

5874:TA09665
gene id: 5874:TA09665
uniprot id: Q4UJ43
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

5874:TA15440
gene id: 5874:TA15440
uniprot id: Q4UDF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

5874:TA17345
gene id: 5874:TA17345
uniprot id: Q4UAM8
names: Function
names: Similarity
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.

5874:TA02660
gene id: 5874:TA02660
uniprot id: Q4UD35
names: Cofactor
messages: Probably binds two magnesium or manganese ions per subunit.

5874:TA11105
gene id: 5874:TA11105
uniprot id: Q4U8H1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

5874:TA12590
gene id: 5874:TA12590
uniprot id: Q4UE35
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

5874:TA16890
gene id: 5874:TA16890
uniprot id: Q4UIL6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA03090
gene id: 5874:TA03090
uniprot id: Q4UHF7
names: Similarity
messages: Belongs to the fl(2)d family.

5874:TA12530
gene id: 5874:TA12530
uniprot id: Q4UE24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Membrane

5874:TA13415
gene id: 5874:TA13415
uniprot id: Q4UEI4
names: Similarity
messages: Belongs to the SF3B5 family.

5874:TA11825
gene id: 5874:TA11825
uniprot id: Q4UDP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

5874:TA14905
gene id: 5874:TA14905
uniprot id: Q4UFA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Heterodimer of two subunits, one of which binds GTP.

5874:TA12830
gene id: 5874:TA12830
uniprot id: Q4UE78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

5874:TA17625
gene id: 5874:TA17625
uniprot id: Q4UBB6
names: Similarity
messages: Belongs to the cullin family.

5874:TA18685
gene id: 5874:TA18685
uniprot id: Q4UBF1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

5874:TA07275
gene id: 5874:TA07275
uniprot id: Q4UA88
names: Similarity
messages: Belongs to the thioredoxin family.

5874:TA03530
gene id: 5874:TA03530
uniprot id: Q4UCJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

5874:TA15785
gene id: 5874:TA15785
uniprot id: Q4UFP0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

5874:TA18130
gene id: 5874:TA18130
uniprot id: Q4UB25
names: Subcellular Location Annotation
messages: Membrane

5874:TA19540
gene id: 5874:TA19540
uniprot id: Q4UGH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

5874:TA18835
gene id: 5874:TA18835
uniprot id: Q4UBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

5874:TA02810
gene id: 5874:TA02810
uniprot id: Q4UHL2
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

5874:TA15495
gene id: 5874:TA15495
uniprot id: Q4UDF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 1 family.
messages: Nucleus

5874:TA21090
gene id: 5874:TA21090
uniprot id: Q4UGT8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA10240
gene id: 5874:TA10240
uniprot id: Q4U8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA05080
gene id: 5874:TA05080
uniprot id: Q4UCV6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

5874:TA06395
gene id: 5874:TA06395
uniprot id: Q4UIB1
names: Similarity
messages: Belongs to the WD repeat SEC31 family.

5874:TA10900
gene id: 5874:TA10900
uniprot id: Q4U974
names: Similarity
messages: Belongs to the NifU family.

5874:TA05620
gene id: 5874:TA05620
uniprot id: Q4UHM9
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA05115
gene id: 5874:TA05115
uniprot id: Q4UBP2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

5874:TA12950
gene id: 5874:TA12950
uniprot id: Q4UEA0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

5874:TA14750
gene id: 5874:TA14750
uniprot id: Q4UF75
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

5874:TA03405
gene id: 5874:TA03405
uniprot id: Q4UCL4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

5874:TA11970
gene id: 5874:TA11970
uniprot id: Q4UDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

5874:TA05170
gene id: 5874:TA05170
uniprot id: Q4UBN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

5874:TA06835
gene id: 5874:TA06835
uniprot id: Q4UHT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

5874:TA05165
gene id: 5874:TA05165
uniprot id: Q4UBN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

5874:TA17280
gene id: 5874:TA17280
uniprot id: Q4UAP1
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA04775
gene id: 5874:TA04775
uniprot id: Q4UBV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

5874:TA03410
gene id: 5874:TA03410
uniprot id: Q4UCL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYF2 family.
messages: Nucleus

5874:TA07885
gene id: 5874:TA07885
uniprot id: Q4U9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

5874:TA06145
gene id: 5874:TA06145
uniprot id: Q4UHP5
names: Similarity
messages: Belongs to the proteasome subunit S2 family.

5874:TA10940
gene id: 5874:TA10940
uniprot id: Q4U982
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03225
gene id: 5874:TA03225
uniprot id: Q4UCP7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

5874:TA03330
gene id: 5874:TA03330
uniprot id: Q4UCM8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

5874:TA06475
gene id: 5874:TA06475
uniprot id: Q4UHQ1
names: Subcellular Location Annotation
messages: Membrane

5874:TA07855
gene id: 5874:TA07855
uniprot id: Q4U9Y3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

5874:TA14045
gene id: 5874:TA14045
uniprot id: Q4UEV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

5874:TA16330
gene id: 5874:TA16330
uniprot id: Q4UIU5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

5874:TA07255
gene id: 5874:TA07255
uniprot id: Q4UA92
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

5874:TA10040
gene id: 5874:TA10040
uniprot id: Q4U8R8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA21275
gene id: 5874:TA21275
uniprot id: Q4UGQ2
names: Similarity
messages: Belongs to the peptidase C19 family.

5874:TA20305
gene id: 5874:TA20305
uniprot id: Q4UH96
names: Subcellular Location Annotation
messages: Nucleus

5874:TA02880
gene id: 5874:TA02880
uniprot id: Q4UHJ8
names: Similarity
messages: Belongs to the MCM family.

5874:TA13470
gene id: 5874:TA13470
uniprot id: Q4UEJ4
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

5874:TA06010
gene id: 5874:TA06010
uniprot id: Q4UI41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

5874:TA10245
gene id: 5874:TA10245
uniprot id: Q4U8V5
names: Similarity
messages: Belongs to the peptidase M24B family.

5874:TA06990
gene id: 5874:TA06990
uniprot id: Q4UHW9
names: Subcellular Location Annotation
messages: nucleolus

5874:TA08609
gene id: 5874:TA08609
uniprot id: Q4UAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA12585
gene id: 5874:TA12585
uniprot id: Q4UE34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

5874:TA03240
gene id: 5874:TA03240
uniprot id: Q4UCP4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

5874:TA21285
gene id: 5874:TA21285
uniprot id: Q4UGQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

5874:TA13945
gene id: 5874:TA13945
uniprot id: Q4UET2
names: Similarity
messages: Belongs to the guanylate kinase family.

5874:TA19190
gene id: 5874:TA19190
uniprot id: Q4UGB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

5874:TA05845
gene id: 5874:TA05845
uniprot id: Q4UI11
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA14165
gene id: 5874:TA14165
uniprot id: Q4UEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum

5874:TA17760
gene id: 5874:TA17760
uniprot id: Q4UB91
names: Subcellular Location Annotation
messages: Nucleus

5874:TA10880
gene id: 5874:TA10880
uniprot id: Q4U970
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

5874:TA12750
gene id: 5874:TA12750
uniprot id: Q4UDA9
names: Similarity
messages: Belongs to the SLBP family.

5874:TA15660
gene id: 5874:TA15660
uniprot id: Q4UDG1
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA02565
gene id: 5874:TA02565
uniprot id: Q4UD16
names: Similarity
messages: Belongs to the WD repeat SEC13 family.

5874:TA17305
gene id: 5874:TA17305
uniprot id: Q4UAN6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

5874:TA14635
gene id: 5874:TA14635
uniprot id: Q4UF55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

5874:TA19300
gene id: 5874:TA19300
uniprot id: Q4UGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP11 family.
messages: nucleolus

5874:TA12560
gene id: 5874:TA12560
uniprot id: Q4UE30
names: Similarity
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.

5874:TA09590
gene id: 5874:TA09590
uniprot id: Q4UJ29
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

5874:TA13370
gene id: 5874:TA13370
uniprot id: Q4UEH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

5874:TA03630
gene id: 5874:TA03630
uniprot id: Q4UCH2
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

5874:TA12145
gene id: 5874:TA12145
uniprot id: Q4UDV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

5874:TA08150
gene id: 5874:TA08150
uniprot id: Q4U9S9
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

5874:TA13660
gene id: 5874:TA13660
uniprot id: Q4UEM9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

5874:TA06920
gene id: 5874:TA06920
uniprot id: Q4UHV5
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA21220
gene id: 5874:TA21220
uniprot id: Q4UGR3
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

5874:TA16180
gene id: 5874:TA16180
uniprot id: Q4UIR7
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

5874:TA03950
gene id: 5874:TA03950
uniprot id: Q4UCB5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

5874:TA14565
gene id: 5874:TA14565
uniprot id: Q4UDE2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

5874:TA15195
gene id: 5874:TA15195
uniprot id: Q4UFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tic20 family.
messages: Membrane

5874:TA11735
gene id: 5874:TA11735
uniprot id: Q4UDN0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

5874:TA12790
gene id: 5874:TA12790
uniprot id: Q4UE71
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

5874:TA03710
gene id: 5874:TA03710
uniprot id: Q4UCY0
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

5874:TA19305
gene id: 5874:TA19305
uniprot id: Q4UGD4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

5874:TA19625
gene id: 5874:TA19625
uniprot id: Q4UGI9
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

5874:TA12715
gene id: 5874:TA12715
uniprot id: Q4UE57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

5874:TA21265
gene id: 5874:TA21265
uniprot id: Q4UGQ4
names: Similarity
messages: Belongs to the peptidase S1C family.

5874:TA18910
gene id: 5874:TA18910
uniprot id: Q4UG64
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

5874:TA16460
gene id: 5874:TA16460
uniprot id: Q4UIW8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

5874:TA10075
gene id: 5874:TA10075
uniprot id: Q4U8S5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

5874:TA15835
gene id: 5874:TA15835
uniprot id: Q4UFQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

5874:TA13465
gene id: 5874:TA13465
uniprot id: Q4UDC2
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

5874:TA17930
gene id: 5874:TA17930
uniprot id: Q4UB61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

5874:TA06585
gene id: 5874:TA06585
uniprot id: Q4UIE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

5874:TA19715
gene id: 5874:TA19715
uniprot id: Q4UFY9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

5874:TA07090
gene id: 5874:TA07090
uniprot id: Q4UAC4
names: Similarity
messages: Belongs to the peptidase C48 family.

5874:TA19515
gene id: 5874:TA19515
uniprot id: Q4UGH0
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

5874:TA17855
gene id: 5874:TA17855
uniprot id: Q4UB74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

5874:TA13570
gene id: 5874:TA13570
uniprot id: Q4UDC3
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

5874:TA09370
gene id: 5874:TA09370
uniprot id: Q4UAD3
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

5874:TA11620
gene id: 5874:TA11620
uniprot id: Q4UDL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

5874:TA04965
gene id: 5874:TA04965
uniprot id: Q4UBR9
names: Subcellular Location Annotation
messages: Membrane

5874:TA04575
gene id: 5874:TA04575
uniprot id: Q4UBZ8
names: Similarity
messages: Belongs to the RuvB family.

5874:TA02690
gene id: 5874:TA02690
uniprot id: Q4UD41
names: Similarity
messages: Belongs to the AFG1 ATPase family.

5874:TA05155
gene id: 5874:TA05155
uniprot id: Q4UBN6
names: Subcellular Location Annotation
messages: Membrane

5874:TA08355
gene id: 5874:TA08355
uniprot id: Q4U9P2
names: Similarity
messages: Belongs to the proteasome subunit S1 family.

5874:TA19885
gene id: 5874:TA19885
uniprot id: Q4UG22
names: Similarity
messages: Belongs to the NifU family.

5874:TA02635
gene id: 5874:TA02635
uniprot id: Q4UD30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

5874:TA16800
gene id: 5874:TA16800
uniprot id: Q4UIJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

5874:TA04120
gene id: 5874:TA04120
uniprot id: Q4UC80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA10930
gene id: 5874:TA10930
uniprot id: Q4U980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

5874:TA12970
gene id: 5874:TA12970
uniprot id: Q4UDB3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

5874:TA09390
gene id: 5874:TA09390
uniprot id: Q4UAC9
names: Similarity
messages: Belongs to the peptidase S14 family.

5874:TA11610
gene id: 5874:TA11610
uniprot id: P16019
names: Similarity
messages: Belongs to the heat shock protein 70 family.

5874:TA14105
gene id: 5874:TA14105
uniprot id: Q4UEW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA02765
gene id: 5874:TA02765
uniprot id: Q4UHM1
names: Subcellular Location Annotation
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane

5874:TA10500
gene id: 5874:TA10500
uniprot id: Q4U901
names: Similarity
messages: Belongs to the heat shock protein 70 family.

5874:TA07210
gene id: 5874:TA07210
uniprot id: Q4UAA0
names: Subcellular Location Annotation
messages: Membrane

5874:TA12620
gene id: 5874:TA12620
uniprot id: Q4UE41
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

5874:TA07460
gene id: 5874:TA07460
uniprot id: Q4UA55
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

5874:TA19455
gene id: 5874:TA19455
uniprot id: Q4UGF9
names: Similarity
messages: Belongs to the BCP1 family.

5874:TA04640
gene id: 5874:TA04640
uniprot id: Q4UCW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA18270
gene id: 5874:TA18270
uniprot id: Q4UBJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

5874:TA17435
gene id: 5874:TA17435
uniprot id: Q4UAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

5874:TA06545
gene id: 5874:TA06545
uniprot id: Q4UID9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

5874:TA03010
gene id: 5874:TA03010
uniprot id: Q4UHH3
names: Similarity
messages: Belongs to the FAM76 family.

5874:TA05230
gene id: 5874:TA05230
uniprot id: Q4UBM2
names: Subcellular Location Annotation
messages: Nucleus

5874:TA06155
gene id: 5874:TA06155
uniprot id: Q4UI67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

5874:TA05740
gene id: 5874:TA05740
uniprot id: Q4UHZ2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA14890
gene id: 5874:TA14890
uniprot id: Q4UDE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

5874:TA19440
gene id: 5874:TA19440
uniprot id: Q4UGF8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA17700
gene id: 5874:TA17700
uniprot id: Q4UBA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

5874:TA12935
gene id: 5874:TA12935
uniprot id: Q4UE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA11780
gene id: 5874:TA11780
uniprot id: Q4UDN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

5874:TA12430
gene id: 5874:TA12430
uniprot id: Q4UE05
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

5874:TA03275
gene id: 5874:TA03275
uniprot id: Q4UCN9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL21 family.

5874:TA06065
gene id: 5874:TA06065
uniprot id: Q4UI52
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA19400
gene id: 5874:TA19400
uniprot id: Q4UGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

5874:TA06235
gene id: 5874:TA06235
uniprot id: Q4UI83
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

5874:TA08340
gene id: 5874:TA08340
uniprot id: Q4U9P5
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

5874:TA14535
gene id: 5874:TA14535
uniprot id: Q4UF36
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

5874:TA18905
gene id: 5874:TA18905
uniprot id: Q4UG63
names: Similarity
messages: Belongs to the KIN17 family.

5874:TA04625
gene id: 5874:TA04625
uniprot id: Q4UBY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

5874:TA08865
gene id: 5874:TA08865
uniprot id: Q4U9E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

5874:TA13960
gene id: 5874:TA13960
uniprot id: Q4UDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

5874:TA14585
gene id: 5874:TA14585
uniprot id: Q4UF45
names: Similarity
messages: Belongs to the VAC14 family.

5874:TA10995
gene id: 5874:TA10995
uniprot id: Q4U991
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA14250
gene id: 5874:TA14250
uniprot id: Q4UEY5
names: Subcellular Location Annotation
messages: Cell surface

5874:TA18476
gene id: 5874:TA18476
uniprot id: Q4UHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

5874:TA20470
gene id: 5874:TA20470
uniprot id: Q4UH63
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

5874:TA14270
gene id: 5874:TA14270
uniprot id: Q4UEY9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

5874:TA13995
gene id: 5874:TA13995
uniprot id: Q4UEU0
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Tetramer of two alpha and two beta subunits.

5874:TA14035
gene id: 5874:TA14035
uniprot id: Q4UEU8
names: Similarity
messages: Belongs to the PPP4R2 family.

5874:TA18410
gene id: 5874:TA18410
uniprot id: Q4UAX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

5874:TA17905
gene id: 5874:TA17905
uniprot id: Q4UB66
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

5874:TA12490
gene id: 5874:TA12490
uniprot id: Q4UE17
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

5874:TA15990
gene id: 5874:TA15990
uniprot id: Q4UDG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

5874:TA20515
gene id: 5874:TA20515
uniprot id: Q4UH54
names: Similarity
messages: Belongs to the MCM family.

5874:TA13875
gene id: 5874:TA13875
uniprot id: Q4UER9
names: Subcellular Location Annotation
messages: Membrane

5874:TA08955
gene id: 5874:TA08955
uniprot id: Q4U9D4
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

5874:TA08515
gene id: 5874:TA08515
uniprot id: Q4U9L2
names: Subcellular Location Annotation
messages: Membrane

5874:TA21210
gene id: 5874:TA21210
uniprot id: Q4UGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

5874:TA05820
gene id: 5874:TA05820
uniprot id: Q4UI06
names: Subcellular Location Annotation
messages: Membrane

5874:TA20635
gene id: 5874:TA20635
uniprot id: Q4UH30
names: Similarity
messages: Belongs to the GcvT family.

5874:TA14910
gene id: 5874:TA14910
uniprot id: Q4UFA4
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

5874:TA09820
gene id: 5874:TA09820
uniprot id: Q4U8M8
names: Similarity
messages: Belongs to the protein kinase superfamily.

5874:TA04990
gene id: 5874:TA04990
uniprot id: Q4UBR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

5874:TA17840
gene id: 5874:TA17840
uniprot id: Q4UB77
names: Similarity
messages: Belongs to the MAK16 family.

5874:TA16815
gene id: 5874:TA16815
uniprot id: Q4UIK1
names: Similarity
messages: Belongs to the TCF25 family.

5874:TA15975
gene id: 5874:TA15975
uniprot id: Q4UFS6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

5874:TA07340
gene id: 5874:TA07340
uniprot id: Q4UA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

5874:TA11305
gene id: 5874:TA11305
uniprot id: Q4U8L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

5874:TA18475
gene id: 5874:TA18475
uniprot id: Q4UAW1
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

5874:TA07695
gene id: 5874:TA07695
uniprot id: Q4UA11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

5874:TA04155
gene id: 5874:TA04155
uniprot id: Q4UC75
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Homotrimer.

5874:TA05060
gene id: 5874:TA05060
uniprot id: Q4UBQ2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

5874:TA02505
gene id: 5874:TA02505
uniprot id: Q4UD04
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.

5874:TA03370
gene id: 5874:TA03370
uniprot id: Q4UCM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

5874:TA06200
gene id: 5874:TA06200
uniprot id: Q4UI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

5874:TA13900
gene id: 5874:TA13900
uniprot id: Q4UDC9
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

5874:TA16310
gene id: 5874:TA16310
uniprot id: Q4UIU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Nucleus

5874:TA18030
gene id: 5874:TA18030
uniprot id: Q4UB43
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

5874:TA08840
gene id: 5874:TA08840
uniprot id: Q4U9F4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

5874:TA10095
gene id: 5874:TA10095
uniprot id: Q4U8S7
names: Similarity
messages: Belongs to the peptidase C19 family.

5874:TA14485
gene id: 5874:TA14485
uniprot id: Q4UF28
names: Subcellular Location Annotation
messages: Membrane

5874:TA10770
gene id: 5874:TA10770
uniprot id: Q4U950
names: Similarity
messages: Belongs to the CDC123 family.

5874:TA03705
gene id: 5874:TA03705
uniprot id: Q4UCY1
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03430
gene id: 5874:TA03430
uniprot id: Q4UCY6
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Homodimer.

5874:TA17755
gene id: 5874:TA17755
uniprot id: Q4UB92
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

5874:TA02655
gene id: 5874:TA02655
uniprot id: Q4UD34
names: Subcellular Location Annotation
messages: nucleolus

5874:TA10365
gene id: 5874:TA10365
uniprot id: Q4U8E7
names: Similarity
messages: Belongs to the importin alpha family.

5874:TA20925
gene id: 5874:TA20925
uniprot id: Q4UGX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

5874:TA13270
gene id: 5874:TA13270
uniprot id: Q4UEF8
names: Similarity
messages: Belongs to the CBP3 family.

5874:TA14630
gene id: 5874:TA14630
uniprot id: Q4UF54
names: Subcellular Location Annotation
messages: Nucleus

5874:TA04975
gene id: 5874:TA04975
uniprot id: Q4UCV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

5874:TA09570
gene id: 5874:TA09570
uniprot id: Q4UJ25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA08205
gene id: 5874:TA08205
uniprot id: Q4U9R9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

5874:TA07715
gene id: 5874:TA07715
uniprot id: Q4UA07
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA10850
gene id: 5874:TA10850
uniprot id: Q4U966
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

5874:TA02970
gene id: 5874:TA02970
uniprot id: Q4UHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: Nucleus

5874:TA14570
gene id: 5874:TA14570
uniprot id: Q4UF42
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

5874:TA12905
gene id: 5874:TA12905
uniprot id: Q4UE93
names: Subcellular Location Annotation
messages: Nucleus

5874:TA02985
gene id: 5874:TA02985
uniprot id: Q4UHH8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

5874:TA13215
gene id: 5874:TA13215
uniprot id: Q4UEE8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA12815
gene id: 5874:TA12815
uniprot id: Q4UE75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

5874:TA08245
gene id: 5874:TA08245
uniprot id: Q4U9R2
names: Similarity
messages: Belongs to the TOP6A family.

5874:TA04580
gene id: 5874:TA04580
uniprot id: Q4UBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA04375
gene id: 5874:TA04375
uniprot id: Q4UC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

5874:TA20250
gene id: 5874:TA20250
uniprot id: Q4UHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

5874:TA07590
gene id: 5874:TA07590
uniprot id: Q4UA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS11 family.
messages: chloroplast

5874:TA05890
gene id: 5874:TA05890
uniprot id: Q4UI19
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

5874:TA11445
gene id: 5874:TA11445
uniprot id: Q4UDH8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03785
gene id: 5874:TA03785
uniprot id: Q4UCE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA05415
gene id: 5874:TA05415
uniprot id: Q4UCS1
names: Subcellular Location Annotation
messages: Membrane

5874:TA09545
gene id: 5874:TA09545
uniprot id: Q4UJ20
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

5874:TA21095
gene id: 5874:TA21095
uniprot id: Q4UGT7
names: Similarity
messages: Belongs to the actin family.

5874:TA08130
gene id: 5874:TA08130
uniprot id: Q4U9T3
names: Similarity
messages: Belongs to the activator 1 small subunits family.

5874:TA15800
gene id: 5874:TA15800
uniprot id: Q4UFP3
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

5874:TA18080
gene id: 5874:TA18080
uniprot id: Q4UB35
names: Subcellular Location Annotation
messages: Membrane

5874:TA03880
gene id: 5874:TA03880
uniprot id: Q4UCC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

5874:TA13515
gene id: 5874:TA13515
uniprot id: Q4UEK3
names: Subcellular Location Annotation
messages: Nucleus

5874:TA13480
gene id: 5874:TA13480
uniprot id: Q4UEJ6
names: Subcellular Location Annotation
messages: Membrane

5874:TA20945
gene id: 5874:TA20945
uniprot id: Q4UGW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

5874:TA17795
gene id: 5874:TA17795
uniprot id: Q4UB86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

5874:TA16140
gene id: 5874:TA16140
uniprot id: Q4UIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

5874:TA18720
gene id: 5874:TA18720
uniprot id: Q4UBE4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

5874:TA05675
gene id: 5874:TA05675
uniprot id: Q4UHY0
names: Similarity
messages: Belongs to the actin family.

5874:TA06415
gene id: 5874:TA06415
uniprot id: Q4UIB5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA04770
gene id: 5874:TA04770
uniprot id: Q4UBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

5874:TA19905
gene id: 5874:TA19905
uniprot id: Q4UG26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

5874:TA08715
gene id: 5874:TA08715
uniprot id: Q4UAI8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

5874:TA09660
gene id: 5874:TA09660
uniprot id: Q4UJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

5874:TA16175
gene id: 5874:TA16175
uniprot id: Q4UIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.

5874:TA16490
gene id: 5874:TA16490
uniprot id: Q4UIX3
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

5874:TA06825
gene id: 5874:TA06825
uniprot id: Q4UHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

5874:TA15825
gene id: 5874:TA15825
uniprot id: Q4UFP8
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA04485
gene id: 5874:TA04485
uniprot id: Q4UC16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

5874:TA20350
gene id: 5874:TA20350
uniprot id: Q4UH87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

5874:TA12005
gene id: 5874:TA12005
uniprot id: Q4UDS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRT-like transporter family.
messages: May regulate endogenous transporter.
messages: Vacuole membrane

5874:TA20750
gene id: 5874:TA20750
uniprot id: Q4UH07
names: Similarity
messages: Belongs to the IPP transferase family.

5874:TA16990
gene id: 5874:TA16990
uniprot id: Q4UIN6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

5874:TA21150
gene id: 5874:TA21150
uniprot id: Q4UGS6
names: Similarity
messages: Belongs to the ZPR1 family.

5874:TA12125
gene id: 5874:TA12125
uniprot id: Q4UDV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

5874:TA06645
gene id: 5874:TA06645
uniprot id: Q4UIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

5874:TA06470
gene id: 5874:TA06470
uniprot id: Q4UIC5
names: Similarity
messages: Belongs to the heat shock protein 90 family.

5874:TA14400
gene id: 5874:TA14400
uniprot id: Q4UDD9
names: Subcellular Location Annotation
messages: Membrane

5874:TA08180
gene id: 5874:TA08180
uniprot id: Q4U9S4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA05695
gene id: 5874:TA05695
uniprot id: Q4UHY4
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

5874:TA14625
gene id: 5874:TA14625
uniprot id: Q4UF53
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

5874:TA16150
gene id: 5874:TA16150
uniprot id: Q4UIR1
names: Subcellular Location Annotation
messages: Membrane

5874:TA02510
gene id: 5874:TA02510
uniprot id: Q4UD05
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA18805
gene id: 5874:TA18805
uniprot id: Q4UBC7
names: Similarity
messages: Belongs to the MOZART1 family.

5874:TA16080
gene id: 5874:TA16080
uniprot id: Q4UDH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

5874:TA16885
gene id: 5874:TA16885
uniprot id: Q4UIL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

5874:TA03735
gene id: 5874:TA03735
uniprot id: Q4UCF4
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA16105
gene id: 5874:TA16105
uniprot id: Q4UIG3
names: Subcellular Location Annotation
messages: Nucleus

5874:TA13210
gene id: 5874:TA13210
uniprot id: Q4UEE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

5874:TA06790
gene id: 5874:TA06790
uniprot id: Q4UHS9
names: Similarity
messages: Belongs to the SAS10 family.

5874:TA16915
gene id: 5874:TA16915
uniprot id: Q4UIM1
names: Subcellular Location Annotation
messages: nucleolus

5874:TA18965
gene id: 5874:TA18965
uniprot id: Q4UG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA16400
gene id: 5874:TA16400
uniprot id: Q4UIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA17785
gene id: 5874:TA17785
uniprot id: Q4UB88
names: Similarity
messages: Belongs to the HAM1 NTPase family.

5874:TA13605
gene id: 5874:TA13605
uniprot id: Q4UEL9
names: Similarity
messages: Belongs to the Luc7 family.

5874:TA04105
gene id: 5874:TA04105
uniprot id: Q4UC83
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

5874:TA17265
gene id: 5874:TA17265
uniprot id: Q4UAP4
names: Similarity
messages: Belongs to the TIP family.

5874:TA07525
gene id: 5874:TA07525
uniprot id: Q4UA43
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA18425
gene id: 5874:TA18425
uniprot id: Q4UAX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

5874:TA09840
gene id: 5874:TA09840
uniprot id: Q4U8N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

5874:TA10720
gene id: 5874:TA10720
uniprot id: Q4U942
names: Similarity
messages: Belongs to the heat shock protein 90 family.

5874:TA02850
gene id: 5874:TA02850
uniprot id: Q4UHK4
names: Similarity
messages: Belongs to the NOP10 family.

5874:TA17685
gene id: 5874:TA17685
uniprot id: Q4UBA5
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA13780
gene id: 5874:TA13780
uniprot id: Q4UEQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

5874:TA21500
gene id: 5874:TA21500
uniprot id: Q4UGK7
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

5874:TA16690
gene id: 5874:TA16690
uniprot id: Q4UJ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

5874:TA04455
gene id: 5874:TA04455
uniprot id: Q4UC21
names: Similarity
messages: Belongs to the UPP synthase family.

5874:TA09940
gene id: 5874:TA09940
uniprot id: Q4U8Q0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

5874:TA09085
gene id: 5874:TA09085
uniprot id: Q4U9B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

5874:TA19345
gene id: 5874:TA19345
uniprot id: Q4UGE0
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

5874:TA07580
gene id: 5874:TA07580
uniprot id: Q4UA34
names: Similarity
messages: Belongs to the BolA/IbaG family.

5874:TA12965
gene id: 5874:TA12965
uniprot id: Q4UEA3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

5874:TA18520
gene id: 5874:TA18520
uniprot id: Q4UBI4
names: Similarity
messages: Belongs to the queuine tRNA-ribosyltransferase family.

5874:TA04585
gene id: 5874:TA04585
uniprot id: Q4UCW5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

5874:TA02895
gene id: 5874:TA02895
uniprot id: Q4UHJ5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family.

5874:TA21460
gene id: 5874:TA21460
uniprot id: Q4UGL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

5874:TA03360
gene id: 5874:TA03360
uniprot id: Q4UCM2
names: Similarity
messages: Belongs to the CWC16 family.

5874:TA20705
gene id: 5874:TA20705
uniprot id: Q4UH16
names: Similarity
messages: Belongs to the acetyltransferase family. GCN5 subfamily.

5874:TA10620
gene id: 5874:TA10620
uniprot id: Q4U923
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

5874:TA05626
gene id: 5874:TA05626
uniprot id: Q4UHN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

5874:TA11800
gene id: 5874:TA11800
uniprot id: Q4UDP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA19525
gene id: 5874:TA19525
uniprot id: Q4UGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

5874:TA21330
gene id: 5874:TA21330
uniprot id: Q4UGP1
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

5874:TA05150
gene id: 5874:TA05150
uniprot id: Q4UBN7
names: Subcellular Location Annotation
messages: Membrane

5874:TA16635
gene id: 5874:TA16635
uniprot id: Q4UIZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

5874:TA07160
gene id: 5874:TA07160
uniprot id: Q4UAB0
names: Similarity
messages: Belongs to the cytidylyltransferase family.

5874:TA18995
gene id: 5874:TA18995
uniprot id: Q4UG80
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

5874:TA11640
gene id: 5874:TA11640
uniprot id: Q4UDL4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA10440
gene id: 5874:TA10440
uniprot id: Q4U8Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

5874:TA06640
gene id: 5874:TA06640
uniprot id: Q4UIF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

5874:TA09680
gene id: 5874:TA09680
uniprot id: Q4UJ46
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

5874:TA15430
gene id: 5874:TA15430
uniprot id: Q4UFH7
names: Similarity
messages: Belongs to the PA28 family.

5874:TA15530
gene id: 5874:TA15530
uniprot id: Q4UFJ5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

5874:TA21115
gene id: 5874:TA21115
uniprot id: Q4UGT3
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

5874:TA17225
gene id: 5874:TA17225
uniprot id: Q4UAQ2
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA05395
gene id: 5874:TA05395
uniprot id: Q4UCS5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA06210
gene id: 5874:TA06210
uniprot id: Q4UI78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA15940
gene id: 5874:TA15940
uniprot id: Q4UFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA20200
gene id: 5874:TA20200
uniprot id: Q4UHB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA07345
gene id: 5874:TA07345
uniprot id: Q4UA76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pescadillo family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

5874:TA05990
gene id: 5874:TA05990
uniprot id: Q4UI37
names: Similarity
messages: Belongs to the IF-3 family.

5874:TA02855
gene id: 5874:TA02855
uniprot id: Q4UHK3
names: Similarity
messages: Belongs to the rtf2 family.

5874:TA06865
gene id: 5874:TA06865
uniprot id: Q4UHU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

5874:TA10255
gene id: 5874:TA10255
uniprot id: Q4U8V7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS21 family.

5874:TA15970
gene id: 5874:TA15970
uniprot id: Q4UFS5
names: Subcellular Location Annotation
messages: Nucleus

5874:TA09915
gene id: 5874:TA09915
uniprot id: Q4U8P6
names: Similarity
messages: Belongs to the VPS29 family.

5874:TA03750
gene id: 5874:TA03750
uniprot id: Q4UCF1
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA19315
gene id: 5874:TA19315
uniprot id: Q4UGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

5874:TA18180
gene id: 5874:TA18180
uniprot id: Q4UB16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic from ER to Golgi (By similarity).

5874:TA02535
gene id: 5874:TA02535
uniprot id: Q4UD10
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

5874:TA19900
gene id: 5874:TA19900
uniprot id: Q4UG25
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

5874:TA10390
gene id: 5874:TA10390
uniprot id: Q4U8Y1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA15365
gene id: 5874:TA15365
uniprot id: Q4UFG5
names: Similarity
messages: Belongs to the cytidylyltransferase family.

5874:TA04270
gene id: 5874:TA04270
uniprot id: Q4UC53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

5874:TA08630
gene id: 5874:TA08630
uniprot id: Q4U9J2
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA20590
gene id: 5874:TA20590
uniprot id: Q4UH39
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

5874:TA06950
gene id: 5874:TA06950
uniprot id: Q4UHW1
names: Subcellular Location Annotation
messages: Nucleus

5874:TA05665
gene id: 5874:TA05665
uniprot id: Q4UHX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

5874:TA05275
gene id: 5874:TA05275
uniprot id: Q4UCU9
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

5874:TA21230
gene id: 5874:TA21230
uniprot id: Q4UGR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

5874:TA02525
gene id: 5874:TA02525
uniprot id: Q4UD08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

5874:TA21415
gene id: 5874:TA21415
uniprot id: Q4UGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

5874:TA10895
gene id: 5874:TA10895
uniprot id: Q4U973
names: Similarity
messages: Belongs to the RRP1 family.

5874:TA05930
gene id: 5874:TA05930
uniprot id: Q4UI26
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

5874:TA08335
gene id: 5874:TA08335
uniprot id: Q4UAJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

5874:TA03640
gene id: 5874:TA03640
uniprot id: Q4UCH0
names: Subcellular Location Annotation
messages: Cell surface

5874:TA17415
gene id: 5874:TA17415
uniprot id: Q4UAU9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA19620
gene id: 5874:TA19620
uniprot id: Q4UGI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA04395
gene id: 5874:TA04395
uniprot id: Q4UC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

5874:TA03575
gene id: 5874:TA03575
uniprot id: Q4UCI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

5874:TA02890
gene id: 5874:TA02890
uniprot id: Q4UHJ6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

5874:TA08085
gene id: 5874:TA08085
uniprot id: Q4U9U2
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

5874:TA11795
gene id: 5874:TA11795
uniprot id: Q4UDP1
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

5874:TA18840
gene id: 5874:TA18840
uniprot id: Q4UBC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA15380
gene id: 5874:TA15380
uniprot id: Q4UFG8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

5874:TA19320
gene id: 5874:TA19320
uniprot id: Q4UGD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

5874:TA02550
gene id: 5874:TA02550
uniprot id: Q4UD13
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

5874:TA19770
gene id: 5874:TA19770
uniprot id: Q4UG00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

5874:TA16830
gene id: 5874:TA16830
uniprot id: Q4UIK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Membrane

5874:TA10795
gene id: 5874:TA10795
uniprot id: Q4U955
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

5874:TA09630
gene id: 5874:TA09630
uniprot id: Q4UJ36
names: Similarity
messages: Belongs to the CKS family.

5874:TA04980
gene id: 5874:TA04980
uniprot id: Q4UBR8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

5874:TA06040
gene id: 5874:TA06040
uniprot id: Q4UI47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Belongs to the NAF1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

5874:TA04740
gene id: 5874:TA04740
uniprot id: Q4UBW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

5874:TA13410
gene id: 5874:TA13410
uniprot id: Q4UDC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Cytoplasm

5874:TA11190
gene id: 5874:TA11190
uniprot id: Q4U8I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Cytoplasm
messages: nucleolus

5874:TA04040
gene id: 5874:TA04040
uniprot id: Q4UC95
names: Similarity
messages: Belongs to the TSR2 family.

5874:TA14420
gene id: 5874:TA14420
uniprot id: Q4UF16
names: Subcellular Location Annotation
messages: Nucleus

5874:TA12510
gene id: 5874:TA12510
uniprot id: Q4UE21
names: Similarity
messages: Belongs to the thymidylate kinase family.

5874:TA05865
gene id: 5874:TA05865
uniprot id: Q4UI15
names: Similarity
messages: Belongs to the HTATSF1 family.

5874:TA05625
gene id: 5874:TA05625
uniprot id: Q4UHN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

5874:TA14685
gene id: 5874:TA14685
uniprot id: Q4UF64
names: Similarity
messages: Belongs to the actin family.

5874:TA09045
gene id: 5874:TA09045
uniprot id: Q4U9B7
names: Similarity
messages: Belongs to the peptidase M17 family.

5874:TA13145
gene id: 5874:TA13145
uniprot id: Q4UED6
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

5874:TA03725
gene id: 5874:TA03725
uniprot id: Q4UCF6
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA07390
gene id: 5874:TA07390
uniprot id: Q4UA67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

5874:TA16775
gene id: 5874:TA16775
uniprot id: Q4UIJ3
names: Similarity
messages: Belongs to the WD repeat EIPR1 family.

5874:TA06320
gene id: 5874:TA06320
uniprot id: Q4UI97
names: Subcellular Location Annotation
messages: Cell surface

5874:TA12155
gene id: 5874:TA12155
uniprot id: Q4UDV7
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

5874:TA07115
gene id: 5874:TA07115
uniprot id: Q4UAB9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

5874:TA13030
gene id: 5874:TA13030
uniprot id: Q4UEB4
names: Caution
names: Function
names: Similarity
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA18175
gene id: 5874:TA18175
uniprot id: Q4UB17
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

5874:TA06720
gene id: 5874:TA06720
uniprot id: Q4UHR5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

5874:TA16325
gene id: 5874:TA16325
uniprot id: Q4UIU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

5874:TA10270
gene id: 5874:TA10270
uniprot id: Q4U8W0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

5874:TA19605
gene id: 5874:TA19605
uniprot id: Q4UGI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal TPase family.
messages: Nucleus

5874:TA05145
gene id: 5874:TA05145
uniprot id: Q4UBN8
names: Subcellular Location Annotation
messages: Membrane

5874:TA14115
gene id: 5874:TA14115
uniprot id: Q4UEW2
names: Similarity
messages: Belongs to the 14-3-3 family.

5874:TA21475
gene id: 5874:TA21475
uniprot id: Q4UGL2
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

5874:TA11615
gene id: 5874:TA11615
uniprot id: Q4UDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

5874:TA06310
gene id: 5874:TA06310
uniprot id: Q4UHP8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

5874:TA06755
gene id: 5874:TA06755
uniprot id: Q4UHS2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA02605
gene id: 5874:TA02605
uniprot id: Q4UD24
names: Subcellular Location Annotation
messages: Nucleus

5874:TA09200
gene id: 5874:TA09200
uniprot id: Q4UAG7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

5874:TA08035
gene id: 5874:TA08035
uniprot id: Q4U9V0
names: Similarity
messages: Belongs to the TRAPPC13 family.

5874:TA02820
gene id: 5874:TA02820
uniprot id: Q4UHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF-assemblin family.
messages: cytoskeleton

5874:TA07555
gene id: 5874:TA07555
uniprot id: Q4UA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Nucleus

5874:TA06665
gene id: 5874:TA06665
uniprot id: Q4UHQ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

5874:TA19585
gene id: 5874:TA19585
uniprot id: Q4UGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA06725
gene id: 5874:TA06725
uniprot id: Q4UHR6
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

5874:TA13495
gene id: 5874:TA13495
uniprot id: Q4UEJ9
names: Subcellular Location Annotation
messages: Membrane

5874:TA21055
gene id: 5874:TA21055
uniprot id: Q4UGU5
names: Similarity
messages: Belongs to the peptidase M24 family.

5874:TA13835
gene id: 5874:TA13835
uniprot id: Q4UER1
names: Subcellular Location Annotation
messages: Membrane

5874:TA19600
gene id: 5874:TA19600
uniprot id: Q4UGI5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA17295
gene id: 5874:TA17295
uniprot id: Q4UAN8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

5874:TA13135
gene id: 5874:TA13135
uniprot id: Q4UED4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA19395
gene id: 5874:TA19395
uniprot id: Q4UGE9
names: Similarity
messages: Belongs to the ATPase gamma chain family.

5874:TA19935
gene id: 5874:TA19935
uniprot id: Q4UG32
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA03645
gene id: 5874:TA03645
uniprot id: Q4UCG9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

5874:TA02795
gene id: 5874:TA02795
uniprot id: Q4UHL5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

5874:TA19645
gene id: 5874:TA19645
uniprot id: Q4UGJ3
names: Subcellular Location Annotation
messages: Membrane

5874:TA16305
gene id: 5874:TA16305
uniprot id: Q4UIU0
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

5874:TA10065
gene id: 5874:TA10065
uniprot id: Q4U8S3
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

5874:TA06490
gene id: 5874:TA06490
uniprot id: Q4UIC8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA20545
gene id: 5874:TA20545
uniprot id: Q4UH48
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

5874:TA19385
gene id: 5874:TA19385
uniprot id: Q4UGE8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

5874:TA03280
gene id: 5874:TA03280
uniprot id: Q4UCN8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

5874:TA03470
gene id: 5874:TA03470
uniprot id: Q4UCK3
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

5874:TA03635
gene id: 5874:TA03635
uniprot id: Q4UCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

5874:TA12025
gene id: 5874:TA12025
uniprot id: Q4UDT3
names: Similarity
messages: Belongs to the syntaxin family.

5874:TA14690
gene id: 5874:TA14690
uniprot id: Q4UF65
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

5874:TA06715
gene id: 5874:TA06715
uniprot id: Q4UHR4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

5874:TA13375
gene id: 5874:TA13375
uniprot id: Q4UEH8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

5874:TA02695
gene id: 5874:TA02695
uniprot id: Q4UD42
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

5874:TA19150
gene id: 5874:TA19150
uniprot id: Q4UGA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

5874:TA21405
gene id: 5874:TA21405
uniprot id: Q4UGM6
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA14795
gene id: 5874:TA14795
uniprot id: Q4UF83
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA11325
gene id: 5874:TA11325
uniprot id: Q4U8L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

5874:TA13260
gene id: 5874:TA13260
uniprot id: Q4UEF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA14650
gene id: 5874:TA14650
uniprot id: Q4UF58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA19545
gene id: 5874:TA19545
uniprot id: Q4UGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

5874:TA13950
gene id: 5874:TA13950
uniprot id: Q4UET3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

5874:TA05120
gene id: 5874:TA05120
uniprot id: Q4UBP1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA08405
gene id: 5874:TA08405
uniprot id: Q4U9N3
names: Similarity
messages: Belongs to the VPS72/YL1 family.

5874:TA05680
gene id: 5874:TA05680
uniprot id: Q4UHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

5874:TA10925
gene id: 5874:TA10925
uniprot id: Q4U979
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

5874:TA11240
gene id: 5874:TA11240
uniprot id: Q4U8J8
names: Similarity
messages: Belongs to the MYG1 family.

5874:TA10425
gene id: 5874:TA10425
uniprot id: Q4U8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cell membrane
messages: Cell surface
messages: Membrane
messages: Nucleus
messages: Vacuole
messages: cytoskeleton

5874:TA14145
gene id: 5874:TA14145
uniprot id: Q4UEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

5874:TA06550
gene id: 5874:TA06550
uniprot id: Q4UIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

5874:TA05880
gene id: 5874:TA05880
uniprot id: Q4UI17
names: Similarity
messages: Belongs to the BRX1 family.

5874:TA19415
gene id: 5874:TA19415
uniprot id: Q4UGF3
names: Similarity
messages: Belongs to the SDHAF4 family.

5874:TA20975
gene id: 5874:TA20975
uniprot id: Q4UGW1
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

5874:TA16235
gene id: 5874:TA16235
uniprot id: Q4UIS8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

5874:TA20680
gene id: 5874:TA20680
uniprot id: Q4UH21
names: Subcellular Location Annotation
messages: Membrane

5874:TA18725
gene id: 5874:TA18725
uniprot id: Q4UBE3
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

5874:TA08610
gene id: 5874:TA08610
uniprot id: Q4UAI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

5874:TA11440
gene id: 5874:TA11440
uniprot id: Q4UDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

5874:TA02750
gene id: 5874:TA02750
uniprot id: Q4UHM4
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA19800
gene id: 5874:TA19800
uniprot id: Q4UG06
names: Similarity
messages: Belongs to the hexokinase family.

5874:TA10380
gene id: 5874:TA10380
uniprot id: Q4U8X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Mitochondrion intermembrane space

5874:TA21490
gene id: 5874:TA21490
uniprot id: Q4UGK9
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

5874:TA08810
gene id: 5874:TA08810
uniprot id: Q4U9F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

5874:TA16745
gene id: 5874:TA16745
uniprot id: Q4UII7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

5874:TA07125
gene id: 5874:TA07125
uniprot id: Q4UAL7
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

5874:TA14590
gene id: 5874:TA14590
uniprot id: Q4UF46
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

5874:TA11835
gene id: 5874:TA11835
uniprot id: Q4UDP8
names: Similarity
messages: Belongs to the type IB topoisomerase family.

5874:TA13555
gene id: 5874:TA13555
uniprot id: Q4UEL1
names: Subcellular Location Annotation
messages: Nucleus

5874:TA16415
gene id: 5874:TA16415
uniprot id: Q4UIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

5874:TA19920
gene id: 5874:TA19920
uniprot id: Q4UG29
names: Subcellular Location Annotation
messages: Nucleus

5874:TA20555
gene id: 5874:TA20555
uniprot id: Q4UH46
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

5874:TA18480
gene id: 5874:TA18480
uniprot id: Q4UBJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

5874:TA06555
gene id: 5874:TA06555
uniprot id: Q4UIE1
names: Similarity
messages: Belongs to the GrpE family.

5874:TA14695
gene id: 5874:TA14695
uniprot id: Q4UF66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

5874:TA04590
gene id: 5874:TA04590
uniprot id: Q4UBZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

5874:TA20775
gene id: 5874:TA20775
uniprot id: Q4UH02
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

5874:TA06960
gene id: 5874:TA06960
uniprot id: Q4UHW3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

5874:TA12600
gene id: 5874:TA12600
uniprot id: Q4UE37
names: Subcellular Location Annotation
messages: Nucleus

5874:TA13310
gene id: 5874:TA13310
uniprot id: Q4UEG6
names: Similarity
messages: Belongs to the CNOT9 family.

5874:TA03425
gene id: 5874:TA03425
uniprot id: Q4UCL0
names: Similarity
messages: Belongs to the SKP1 family.

5874:TA06445
gene id: 5874:TA06445
uniprot id: Q4UIC0
names: Similarity
messages: Belongs to the TPPP family.

5874:TA15210
gene id: 5874:TA15210
uniprot id: Q4UFD7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

5874:TA20910
gene id: 5874:TA20910
uniprot id: Q4UGX3
names: Similarity
messages: Belongs to the peptidase M1 family.

5874:TA08985
gene id: 5874:TA08985
uniprot id: Q4U9C8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA15900
gene id: 5874:TA15900
uniprot id: Q4UFQ8
names: Similarity
messages: Belongs to the peptidase T1A family.

5874:TA13670
gene id: 5874:TA13670
uniprot id: Q4UEN1
names: Similarity
messages: Belongs to the UFD1 family.

5874:TA12445
gene id: 5874:TA12445
uniprot id: Q4UE08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA13565
gene id: 5874:TA13565
uniprot id: Q4UEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

5874:TA11730
gene id: 5874:TA11730
uniprot id: Q4UDM9
names: Similarity
messages: Belongs to the PHF5 family.

5874:TA15830
gene id: 5874:TA15830
uniprot id: Q4UFP9
names: Subcellular Location Annotation
messages: Membrane

5874:TA13340
gene id: 5874:TA13340
uniprot id: Q4UEH2
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

5874:TA07505
gene id: 5874:TA07505
uniprot id: Q4UAL1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA11030
gene id: 5874:TA11030
uniprot id: Q4U997
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

5874:TA04700
gene id: 5874:TA04700
uniprot id: Q4UCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm

5874:TA13095
gene id: 5874:TA13095
uniprot id: Q4UEC7
names: Similarity
messages: Belongs to the NDK family.

5874:TA21360
gene id: 5874:TA21360
uniprot id: Q4UGN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

5874:TA05175
gene id: 5874:TA05175
uniprot id: Q4UBN2
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

5874:TA20810
gene id: 5874:TA20810
uniprot id: Q4UGZ3
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

5874:TA04860
gene id: 5874:TA04860
uniprot id: Q4UCW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

5874:TA15375
gene id: 5874:TA15375
uniprot id: Q4UFG7
names: Similarity
messages: Belongs to the SNAP family.

5874:TA09645
gene id: 5874:TA09645
uniprot id: Q4UJ39
names: Similarity
messages: Belongs to the LplA family.

5874:TA04605
gene id: 5874:TA04605
uniprot id: Q4UBZ3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA07925
gene id: 5874:TA07925
uniprot id: Q4U9X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

5874:TA16405
gene id: 5874:TA16405
uniprot id: Q4UIH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

5874:TA12615
gene id: 5874:TA12615
uniprot id: Q4UE40
names: Similarity
messages: Belongs to the ATG8 family.

5874:TA19080
gene id: 5874:TA19080
uniprot id: Q4UG95
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

5874:TA21035
gene id: 5874:TA21035
uniprot id: Q4UGU9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

5874:TA02965
gene id: 5874:TA02965
uniprot id: Q4UHI2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

5874:TA15875
gene id: 5874:TA15875
uniprot id: Q4UFQ8
names: Similarity
messages: Belongs to the peptidase T1A family.

5874:TA11880
gene id: 5874:TA11880
uniprot id: Q4UDQ7
names: Similarity
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

5874:TA04170
gene id: 5874:TA04170
uniprot id: Q4UC72
names: Subcellular Location Annotation
messages: Membrane

5874:TA07780
gene id: 5874:TA07780
uniprot id: Q4UAK6
names: Similarity
messages: Belongs to the Rab GDI family.

5874:TA19500
gene id: 5874:TA19500
uniprot id: Q4UGG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

5874:TA21355
gene id: 5874:TA21355
uniprot id: Q4UGN6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

5874:TA02675
gene id: 5874:TA02675
uniprot id: Q4UD38
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

5874:TA08380
gene id: 5874:TA08380
uniprot id: Q4U9N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

5874:TA17315
gene id: 5874:TA17315
uniprot id: Q8WPH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

5874:TA08530
gene id: 5874:TA08530
uniprot id: Q4U9K9
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

5874:TA06185
gene id: 5874:TA06185
uniprot id: Q4UI73
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Tetramer of two alpha and two beta subunits.

5874:TA20845
gene id: 5874:TA20845
uniprot id: Q4UGY6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

5874:TA15670
gene id: 5874:TA15670
uniprot id: Q4UFM0
names: Subcellular Location Annotation
messages: nucleolus

5874:TA17235
gene id: 5874:TA17235
uniprot id: Q4UAQ0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.
messages: Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

5874:TA07845
gene id: 5874:TA07845
uniprot id: Q4U9Y5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA08545
gene id: 5874:TA08545
uniprot id: Q4U9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

5874:TA07290
gene id: 5874:TA07290
uniprot id: Q4UAL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA10515
gene id: 5874:TA10515
uniprot id: Q4U904
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

5874:TA06180
gene id: 5874:TA06180
uniprot id: Q4UI72
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

5874:TA02830
gene id: 5874:TA02830
uniprot id: Q4UHK8
names: Similarity
messages: Belongs to the CDK5RAP3 family.

5874:TA20650
gene id: 5874:TA20650
uniprot id: Q4UH27
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

5874:TA16785
gene id: 5874:TA16785
uniprot id: Q4UIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

5874:TA12000
gene id: 5874:TA12000
uniprot id: Q4UDS8
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

5874:TA04250
gene id: 5874:TA04250
uniprot id: Q4UC57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

5874:TA10340
gene id: 5874:TA10340
uniprot id: Q4U8X2
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

5874:TA21030
gene id: 5874:TA21030
uniprot id: Q4UGV0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

5874:TA04530
gene id: 5874:TA04530
uniprot id: Q4UC07
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA15545
gene id: 5874:TA15545
uniprot id: Q4UFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Enzyme with a broad specificity.
messages: Membrane

5874:TA17330
gene id: 5874:TA17330
uniprot id: Q4UAN1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

5874:TA04940
gene id: 5874:TA04940
uniprot id: Q4UBS4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

5874:TA05950
gene id: 5874:TA05950
uniprot id: Q4UI30
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA03860
gene id: 5874:TA03860
uniprot id: Q4UCD1
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA09185
gene id: 5874:TA09185
uniprot id: Q4UAH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

5874:TA03660
gene id: 5874:TA03660
uniprot id: Q4UCG7
names: Similarity
messages: Belongs to the frataxin family.

5874:TA09195
gene id: 5874:TA09195
uniprot id: Q4UAG8
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.

5874:TA18300
gene id: 5874:TA18300
uniprot id: Q4UAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26B family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA11130
gene id: 5874:TA11130
uniprot id: Q4U8H6
names: Similarity
messages: Belongs to the peptidase C48 family.

5874:TA03720
gene id: 5874:TA03720
uniprot id: Q4UCF7
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA09235
gene id: 5874:TA09235
uniprot id: Q4UAG0
names: Similarity
messages: Belongs to the SUI1 family.

5874:TA12740
gene id: 5874:TA12740
uniprot id: Q4UE62
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

5874:TA08735
gene id: 5874:TA08735
uniprot id: Q4U9H3
names: Similarity
messages: Belongs to the KRI1 family.

5874:TA08685
gene id: 5874:TA08685
uniprot id: Q4U9I1
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

5874:TA07355
gene id: 5874:TA07355
uniprot id: Q4UA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

5874:TA19280
gene id: 5874:TA19280
uniprot id: Q4UFX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA14075
gene id: 5874:TA14075
uniprot id: Q4UEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

5874:TA12385
gene id: 5874:TA12385
uniprot id: Q4UDZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

5874:TA12850
gene id: 5874:TA12850
uniprot id: Q4UE82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

5874:TA06845
gene id: 5874:TA06845
uniprot id: Q4UHU0
names: Similarity
messages: Belongs to the heat shock protein 90 family.

5874:TA14155
gene id: 5874:TA14155
uniprot id: Q4UEX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA16525
gene id: 5874:TA16525
uniprot id: Q4UIY0
names: Subcellular Location Annotation
messages: Membrane

5874:TA14640
gene id: 5874:TA14640
uniprot id: Q4UF56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

5874:TA07180
gene id: 5874:TA07180
uniprot id: Q4UAA6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

5874:TA08775
gene id: 5874:TA08775
uniprot id: Q4U9G5
names: Function
names: Similarity
messages: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.
messages: In the C-terminal section; belongs to the thymidylate synthase family.
messages: In the N-terminal section; belongs to the dihydrofolate reductase family.

5874:TA07540
gene id: 5874:TA07540
uniprot id: Q4UA40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

5874:TA20995
gene id: 5874:TA20995
uniprot id: Q4UGV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Nucleus

5874:TA20815
gene id: 5874:TA20815
uniprot id: Q4UGZ2
names: Similarity
messages: Belongs to the TBP family.

5874:TA16335
gene id: 5874:TA16335
uniprot id: Q4UIU6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA18040
gene id: 5874:TA18040
uniprot id: Q4UB41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: apicoplast

5874:TA14705
gene id: 5874:TA14705
uniprot id: Q4UF68
names: Similarity
messages: Belongs to the RRF family.

5874:TA04380
gene id: 5874:TA04380
uniprot id: Q4UC34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

5874:TA04015
gene id: 5874:TA04015
uniprot id: Q4UCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA08195
gene id: 5874:TA08195
uniprot id: Q4U9S1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

5874:TA13585
gene id: 5874:TA13585
uniprot id: Q4UEL5
names: Similarity
messages: Belongs to the SNW family.

5874:TA15100
gene id: 5874:TA15100
uniprot id: Q4UFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

5874:TA10610
gene id: 5874:TA10610
uniprot id: Q4U921
names: Similarity
messages: Belongs to the RuvB family.

5874:TA07825
gene id: 5874:TA07825
uniprot id: Q4U9Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Vacuole membrane

5874:TA08225
gene id: 5874:TA08225
uniprot id: Q4U9R6
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

5874:TA17025
gene id: 5874:TA17025
uniprot id: Q4UIP3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

5874:TA10050
gene id: 5874:TA10050
uniprot id: Q4U8S0
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA12090
gene id: 5874:TA12090
uniprot id: Q4UDU5
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

5874:TA13975
gene id: 5874:TA13975
uniprot id: Q4UET6
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.

5874:TA09295
gene id: 5874:TA09295
uniprot id: Q4UAE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

5874:TA11345
gene id: 5874:TA11345
uniprot id: Q4U8L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

5874:TA16930
gene id: 5874:TA16930
uniprot id: Q4UIM4
names: Similarity
messages: Belongs to the AAR2 family.

5874:TA18020
gene id: 5874:TA18020
uniprot id: Q4UB45
names: Subcellular Location Annotation
messages: Nucleus

5874:TA05365
gene id: 5874:TA05365
uniprot id: Q4UCT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

5874:TA21110
gene id: 5874:TA21110
uniprot id: Q4UGT4
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

5874:TA02790
gene id: 5874:TA02790
uniprot id: Q4UHL6
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

5874:TA18630
gene id: 5874:TA18630
uniprot id: Q4UBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

5874:TA14800
gene id: 5874:TA14800
uniprot id: Q4UF84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

5874:TA19100
gene id: 5874:TA19100
uniprot id: Q4UG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

5874:TA11215
gene id: 5874:TA11215
uniprot id: Q4U8J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

5874:TA05325
gene id: 5874:TA05325
uniprot id: Q4UCT9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA07915
gene id: 5874:TA07915
uniprot id: Q4U9X3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

5874:TA18025
gene id: 5874:TA18025
uniprot id: Q4UB44
names: Similarity
messages: Belongs to the MAPRE family.

5874:TA19850
gene id: 5874:TA19850
uniprot id: Q4UG15
names: Similarity
messages: Belongs to the OPA3 family.

5874:TA18350
gene id: 5874:TA18350
uniprot id: Q4UAY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

5874:TA13795
gene id: 5874:TA13795
uniprot id: Q4UDC8
names: Similarity
messages: Belongs to the NUF2 family.

5874:TA04055
gene id: 5874:TA04055
uniprot id: Q4UC92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

5874:TA08575
gene id: 5874:TA08575
uniprot id: Q4U9K2
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

5874:TA11380
gene id: 5874:TA11380
uniprot id: Q4U8M6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA05010
gene id: 5874:TA05010
uniprot id: Q4UBR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

5874:TA07020
gene id: 5874:TA07020
uniprot id: Q4UHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

5874:TA19225
gene id: 5874:TA19225
uniprot id: Q4UGC0
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

5874:TA09180
gene id: 5874:TA09180
uniprot id: Q4UAH1
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

5874:TA12060
gene id: 5874:TA12060
uniprot id: Q4UDT9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.

5874:TA02610
gene id: 5874:TA02610
uniprot id: Q4UD25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

5874:TA06650
gene id: 5874:TA06650
uniprot id: Q4UIF8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

5874:TA03765
gene id: 5874:TA03765
uniprot id: Q4UCX9
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

5874:TA06655
gene id: 5874:TA06655
uniprot id: Q4UIF9
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

5874:TA14515
gene id: 5874:TA14515
uniprot id: Q4UF32
names: Similarity
messages: Belongs to the CAF1 family.

5874:TA09530
gene id: 5874:TA09530
uniprot id: Q4UJ17
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

5874:TA12390
gene id: 5874:TA12390
uniprot id: Q4UDZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

5874:TA15475
gene id: 5874:TA15475
uniprot id: Q4UFI5
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

5874:TA02540
gene id: 5874:TA02540
uniprot id: Q4UD11
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

5874:TA07895
gene id: 5874:TA07895
uniprot id: Q4UAK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

5874:TA21025
gene id: 5874:TA21025
uniprot id: Q4UGV1
names: Similarity
messages: Belongs to the LTV1 family.

5874:TA03380
gene id: 5874:TA03380
uniprot id: Q4UCL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

5874:TA04900
gene id: 5874:TA04900
uniprot id: Q4UBT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

5874:TA18550
gene id: 5874:TA18550
uniprot id: Q4UBH8
names: Similarity
messages: Belongs to the CMC family.
messages: Belongs to the EAF6 family.

5874:TA04075
gene id: 5874:TA04075
uniprot id: Q4UC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

5874:TA18205
gene id: 5874:TA18205
uniprot id: Q4UB11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

5874:TA16535
gene id: 5874:TA16535
uniprot id: Q4UIY2
names: Subcellular Location Annotation
messages: Nucleus

5874:TA12015
gene id: 5874:TA12015
uniprot id: Q4UDT1
names: Subcellular Location Annotation
messages: Nucleus

5874:TA09860
gene id: 5874:TA09860
uniprot id: Q4U8N6
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.

5874:TA07550
gene id: 5874:TA07550
uniprot id: Q4UA38
names: Subcellular Location Annotation
messages: Nucleus

5874:TA14280
gene id: 5874:TA14280
uniprot id: Q4UEZ1
names: Similarity
messages: Belongs to the SF3A2 family.

5874:TA20060
gene id: 5874:TA20060
uniprot id: Q4UG57
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

5874:TA04030
gene id: 5874:TA04030
uniprot id: Q4UC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA20475
gene id: 5874:TA20475
uniprot id: Q4UH62
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

5874:TA07745
gene id: 5874:TA07745
uniprot id: Q4UA02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

5874:TA21215
gene id: 5874:TA21215
uniprot id: Q4UGR4
names: Similarity
messages: Belongs to the NOB1 family.

5874:TA13455
gene id: 5874:TA13455
uniprot id: Q4UEJ2
names: Similarity
messages: Belongs to the p23/wos2 family.

5874:TA08935
gene id: 5874:TA08935
uniprot id: Q4U9D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

5874:TA06570
gene id: 5874:TA06570
uniprot id: Q4UIE4
names: Similarity
messages: Belongs to the Tim44 family.

5874:TA11175
gene id: 5874:TA11175
uniprot id: Q4U8I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

5874:TA10295
gene id: 5874:TA10295
uniprot id: Q4U8W5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

5874:TA09965
gene id: 5874:TA09965
uniprot id: Q4U8Q5
names: Subcellular Location Annotation
messages: Nucleus

5874:TA11460
gene id: 5874:TA11460
uniprot id: Q4UDI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

5874:TA08065
gene id: 5874:TA08065
uniprot id: Q4U9U6
names: Similarity
messages: Belongs to the peptidase S9A family.

5874:TA19735
gene id: 5874:TA19735
uniprot id: Q4UFZ3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

5874:TA09105
gene id: 5874:TA09105
uniprot id: Q4U9A6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA09025
gene id: 5874:TA09025
uniprot id: Q4U9C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

5874:TA19155
gene id: 5874:TA19155
uniprot id: Q4UGA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

5874:TA02910
gene id: 5874:TA02910
uniprot id: Q4UHJ2
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

5874:TA04180
gene id: 5874:TA04180
uniprot id: Q4UC70
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

5874:TA08170
gene id: 5874:TA08170
uniprot id: Q4U9S6
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

5874:TA16780
gene id: 5874:TA16780
uniprot id: Q4UIJ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

5874:TA17010
gene id: 5874:TA17010
uniprot id: Q4UIP0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA15420
gene id: 5874:TA15420
uniprot id: Q4UFH5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

5874:TA08845
gene id: 5874:TA08845
uniprot id: Q4U9F3
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

5874:TA10820
gene id: 5874:TA10820
uniprot id: Q4U960
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

5874:TA18945
gene id: 5874:TA18945
uniprot id: Q4UG71
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Directly inhibited by buparvaquone and juglone anti-parasite drugs. Inhibited at lesser degree by the non-quinone inhibitor dipentamethylene thiuram monosulphide (DTM).
messages: Host cytoplasm
messages: Host nucleus
messages: Interacts with host FBXW7; leading to FBXW7 autoubiquitination and subsequent degradation.
messages: PIN1 harbors a single amino acid variation in a strain resistant to buparvaquone (AC P0DMT5).
messages: Peptidyl-prolyl cis/trans isomerase (PPIase) that acts as a key virulence factor by promoting host leukocyte transformation. Binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins. Promotes host leukocyte transformation by binding to phosphorylated host FBXW7, disrupting dimerization and promoting FBXW7 autoubiquitination and subsequent degradation. Degradation of host FBXW7, leads to stabilization of JUN, which promotes cell transformation.
messages: Secreted

5874:TA18845
gene id: 5874:TA18845
uniprot id: Q4UBB9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA10005
gene id: 5874:TA10005
uniprot id: Q4U8R2
names: Similarity
messages: Belongs to the VPS26 family.

5874:TA05630
gene id: 5874:TA05630
uniprot id: Q4UHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA12370
gene id: 5874:TA12370
uniprot id: Q4UDZ4
names: Subcellular Location Annotation
messages: Membrane

5874:TA11660
gene id: 5874:TA11660
uniprot id: Q4UDL6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

5874:TA15065
gene id: 5874:TA15065
uniprot id: Q4UFV1
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

5874:TA08750
gene id: 5874:TA08750
uniprot id: Q4U9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

5874:TA17420
gene id: 5874:TA17420
uniprot id: Q4UAV0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

5874:TA17190
gene id: 5874:TA17190
uniprot id: Q4UAQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

5874:TA20345
gene id: 5874:TA20345
uniprot id: Q4UH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Nucleus

5874:TA20410
gene id: 5874:TA20410
uniprot id: Q4UH75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

5874:TA15665
gene id: 5874:TA15665
uniprot id: Q4UFL9
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

5874:TA08990
gene id: 5874:TA08990
uniprot id: Q4U9C7
names: Similarity
messages: Belongs to the MEMO1 family.

5874:TA04060
gene id: 5874:TA04060
uniprot id: Q4UC91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

5874:TA16710
gene id: 5874:TA16710
uniprot id: Q4UII0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

5874:TA20075
gene id: 5874:TA20075
uniprot id: Q4UG60
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

5874:TA14320
gene id: 5874:TA14320
uniprot id: Q4UEZ8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

5874:TA18815
gene id: 5874:TA18815
uniprot id: Q4UBC5
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA07350
gene id: 5874:TA07350
uniprot id: Q4UA75
names: Similarity
messages: Belongs to the RecA family.

5874:TA12640
gene id: 5874:TA12640
uniprot id: Q4UE44
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

5874:TA13810
gene id: 5874:TA13810
uniprot id: Q4UEQ6
names: Subcellular Location Annotation
messages: Membrane

5874:TA15255
gene id: 5874:TA15255
uniprot id: Q4UFE5
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

5874:TA17925
gene id: 5874:TA17925
uniprot id: Q4UB62
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

5874:TA03230
gene id: 5874:TA03230
uniprot id: Q4UCP6
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

5874:TA19205
gene id: 5874:TA19205
uniprot id: Q4UGB6
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA04840
gene id: 5874:TA04840
uniprot id: Q4UBU1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

5874:TA12870
gene id: 5874:TA12870
uniprot id: Q4UE86
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

5874:TA08265
gene id: 5874:TA08265
uniprot id: Q4U9Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA09725
gene id: 5874:TA09725
uniprot id: Q4UJ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA20715
gene id: 5874:TA20715
uniprot id: Q4UH14
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

5874:TA10915
gene id: 5874:TA10915
uniprot id: Q4U977
names: Similarity
messages: Belongs to the pyruvate kinase family.

5874:TA09075
gene id: 5874:TA09075
uniprot id: Q4U9B2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

5874:TA16630
gene id: 5874:TA16630
uniprot id: Q4UIH8
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03015
gene id: 5874:TA03015
uniprot id: Q4UHH2
names: Similarity
messages: Belongs to the DIM1 family.

5874:TA04275
gene id: 5874:TA04275
uniprot id: Q4UC52
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

5874:TA07200
gene id: 5874:TA07200
uniprot id: Q4UAA2
names: Subcellular Location Annotation
messages: Membrane

5874:TA14500
gene id: 5874:TA14500
uniprot id: Q4UF31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

5874:TA12070
gene id: 5874:TA12070
uniprot id: Q4UDU1
names: Similarity
messages: Belongs to the NKAP family.

5874:TA07410
gene id: 5874:TA07410
uniprot id: Q4UA64
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

5874:TA07800
gene id: 5874:TA07800
uniprot id: Q4U9Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

5874:TA04600
gene id: 5874:TA04600
uniprot id: Q4UBZ4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

5874:TA11870
gene id: 5874:TA11870
uniprot id: Q4UDQ5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA19380
gene id: 5874:TA19380
uniprot id: Q4UGE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

5874:TA21305
gene id: 5874:TA21305
uniprot id: Q4UGP6
names: Subcellular Location Annotation
messages: Cytoplasm

5874:TA04430
gene id: 5874:TA04430
uniprot id: Q4UC26
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA08625
gene id: 5874:TA08625
uniprot id: Q4U9J3
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

5874:TA11865
gene id: 5874:TA11865
uniprot id: Q4UDQ4
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.

5874:TA12435
gene id: 5874:TA12435
uniprot id: Q4UE06
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

5874:TA10990
gene id: 5874:TA10990
uniprot id: Q4U990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

5874:TA03495
gene id: 5874:TA03495
uniprot id: Q4UCJ8
names: Similarity
messages: Belongs to the formin-like family. Class-II subfamily.

5874:TA19535
gene id: 5874:TA19535
uniprot id: Q4UGH4
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

5874:TA09735
gene id: 5874:TA09735
uniprot id: Q4UJ57
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA06515
gene id: 5874:TA06515
uniprot id: Q4UID3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

5874:TA13550
gene id: 5874:TA13550
uniprot id: Q4UEL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

5874:TA16240
gene id: 5874:TA16240
uniprot id: Q4UIH0
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

5874:TA04070
gene id: 5874:TA04070
uniprot id: Q4UC89
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

5874:TA09495
gene id: 5874:TA09495
uniprot id: Q4UBX4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA18095
gene id: 5874:TA18095
uniprot id: Q4UB32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Nucleus
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

5874:TA20105
gene id: 5874:TA20105
uniprot id: Q4UHD5
names: Similarity
messages: Belongs to the COG4 family.

5874:TA06910
gene id: 5874:TA06910
uniprot id: Q4UHV3
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

5874:TA16100
gene id: 5874:TA16100
uniprot id: Q4UIG2
names: Similarity
messages: Belongs to the type-1 OGG1 family.

5874:TA06410
gene id: 5874:TA06410
uniprot id: Q4UIB4
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

5874:TA08615
gene id: 5874:TA08615
uniprot id: Q4U9J5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

5874:TA07495
gene id: 5874:TA07495
uniprot id: Q4UA48
names: Similarity
messages: Belongs to the RRN3 family.

5874:TA13400
gene id: 5874:TA13400
uniprot id: Q4UEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

5874:TA03485
gene id: 5874:TA03485
uniprot id: Q4UCK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

5874:TA04505
gene id: 5874:TA04505
uniprot id: Q4UC12
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

5874:TA15715
gene id: 5874:TA15715
uniprot id: Q4UDG2
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA02705
gene id: 5874:TA02705
uniprot id: Q4UD44
names: Similarity
messages: Belongs to the archease family.

5874:TA15385
gene id: 5874:TA15385
uniprot id: Q4UDF6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

5874:TA07065
gene id: 5874:TA07065
uniprot id: Q4UAL9
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

5874:TA09750
gene id: 5874:TA09750
uniprot id: Q4UJ60
names: Similarity
messages: Belongs to the cyclin family.

5874:TA12765
gene id: 5874:TA12765
uniprot id: Q4UE66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

5874:TA13315
gene id: 5874:TA13315
uniprot id: Q4UEG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

5874:TA12845
gene id: 5874:TA12845
uniprot id: Q4UE81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

5874:TA17035
gene id: 5874:TA17035
uniprot id: Q4UIP5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA19470
gene id: 5874:TA19470
uniprot id: Q4UGG2
names: Similarity
messages: Belongs to the PPP phosphatase family.

5874:TA06335
gene id: 5874:TA06335
uniprot id: Q4UIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

5874:TA09345
gene id: 5874:TA09345
uniprot id: Q4UAD8
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

5874:TA05735
gene id: 5874:TA05735
uniprot id: Q4UHZ1
names: Similarity
messages: Belongs to the peptidase A1 family.

5874:TA10260
gene id: 5874:TA10260
uniprot id: Q4U8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: nuclear pore complex

5874:TA19595
gene id: 5874:TA19595
uniprot id: Q4UGI4
names: Similarity
messages: Belongs to the DDB1 family.

5874:TA10305
gene id: 5874:TA10305
uniprot id: Q4U8E5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

5874:TA14150
gene id: 5874:TA14150
uniprot id: Q4UEW9
names: Similarity
messages: Belongs to the FAM136 family.

5874:TA19285
gene id: 5874:TA19285
uniprot id: Q4UGD0
names: Subcellular Location Annotation
messages: chloroplast

5874:TA16825
gene id: 5874:TA16825
uniprot id: Q4UIK3
names: Similarity
messages: Belongs to the actin family.

5874:TA08645
gene id: 5874:TA08645
uniprot id: Q4U9I9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

5874:TA17990
gene id: 5874:TA17990
uniprot id: Q4UB51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat CIA1 family.
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA13805
gene id: 5874:TA13805
uniprot id: Q4UEQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

5874:TA15510
gene id: 5874:TA15510
uniprot id: Q4UFJ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.
messages: Cytoplasm

5874:TA11125
gene id: 5874:TA11125
uniprot id: Q4U8H5
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

5874:TA02490
gene id: 5874:TA02490
uniprot id: Q4UD01
names: Subcellular Location Annotation
messages: nucleolus

5874:TA06425
gene id: 5874:TA06425
uniprot id: Q4UIB6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

5874:TA10105
gene id: 5874:TA10105
uniprot id: Q4U8S9
names: Similarity
messages: Belongs to the RMD1/sif2 family.

5874:TA17430
gene id: 5874:TA17430
uniprot id: Q4UAV2
names: Similarity
messages: Belongs to the MOG1 family.

5874:TA09900
gene id: 5874:TA09900
uniprot id: Q4U8P3
names: Similarity
messages: Belongs to the MIP18 family.

5874:TA17895
gene id: 5874:TA17895
uniprot id: Q4UB68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

5874:TA14970
gene id: 5874:TA14970
uniprot id: Q4UFV8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

5874:TA07735
gene id: 5874:TA07735
uniprot id: Q4UA04
names: Similarity
messages: Belongs to the CDC73 family.

5874:TA20655
gene id: 5874:TA20655
uniprot id: Q4UH26
names: Similarity
messages: Belongs to the PITHD1 family.

5874:TA14355
gene id: 5874:TA14355
uniprot id: Q4UF05
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

5874:TA07415
gene id: 5874:TA07415
uniprot id: Q4UA63
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

5874:TA18420
gene id: 5874:TA18420
uniprot id: Q4UAX1
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA15745
gene id: 5874:TA15745
uniprot id: Q4UFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA03395
gene id: 5874:TA03395
uniprot id: Q4UCL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

5874:TA05225
gene id: 5874:TA05225
uniprot id: Q4UBM3
names: Similarity
messages: Belongs to the GET4 family.

5874:TA06085
gene id: 5874:TA06085
uniprot id: Q4UHP3
names: Similarity
messages: Belongs to the WD repeat EIF2A family.

5874:TA07075
gene id: 5874:TA07075
uniprot id: Q4UAC7
names: Similarity
messages: Belongs to the RecA family.

5874:TA12465
gene id: 5874:TA12465
uniprot id: Q4UE12
names: Similarity
messages: Belongs to the GroES chaperonin family.

5874:TA02980
gene id: 5874:TA02980
uniprot id: Q4UHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apicomplexan parasites AMA1 family.
messages: Membrane

5874:TA10700
gene id: 5874:TA10700
uniprot id: Q4U938
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

5874:TA18225
gene id: 5874:TA18225
uniprot id: Q4UB08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

5874:TA13290
gene id: 5874:TA13290
uniprot id: Q4UEG2
names: Subcellular Location Annotation
messages: Membrane

5874:TA09060
gene id: 5874:TA09060
uniprot id: Q4U9B5
names: Similarity
messages: Belongs to the DEAD box helicase family.

5874:TA04595
gene id: 5874:TA04595
uniprot id: Q4UBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

5874:TA19965
gene id: 5874:TA19965
uniprot id: Q4UG38
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

5874:TA13120
gene id: 5874:TA13120
uniprot id: Q4UED2
names: Similarity
messages: Belongs to the DENR family.

5874:TA14525
gene id: 5874:TA14525
uniprot id: Q4UF34
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

5874:TA03190
gene id: 5874:TA03190
uniprot id: Q4UCZ4
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

5874:TA08565
gene id: 5874:TA08565
uniprot id: Q4U9K4
names: Similarity
messages: Belongs to the lipin family.

5874:TA18830
gene id: 5874:TA18830
uniprot id: Q4UBC2
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

5874:TA09740
gene id: 5874:TA09740
uniprot id: Q4UJ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

5874:TA08650
gene id: 5874:TA08650
uniprot id: Q4U9I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Probable GTP-binding protein that may be involved in cell development.

5874:TA17465
gene id: 5874:TA17465
uniprot id: Q4UAV9
names: Similarity
messages: Belongs to the peptidase C13 family.

5874:TA16570
gene id: 5874:TA16570
uniprot id: Q4UIH6
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.

5874:TA12095
gene id: 5874:TA12095
uniprot id: Q4UDU6
names: Similarity
messages: Belongs to the SCO1/2 family.

5874:TA18605
gene id: 5874:TA18605
uniprot id: Q4UBG7
names: Similarity
messages: Belongs to the TMEM121 family.

5874:TA18362
gene id: 5874:TA18362
uniprot id: Q4UAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

5874:TA17250
gene id: 5874:TA17250
uniprot id: Q4UAP7
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

5874:TA11045
gene id: 5874:TA11045
uniprot id: Q4U9A0
names: Similarity
messages: Belongs to the cyclin family.

5874:TA18400
gene id: 5874:TA18400
uniprot id: Q4UAX5
names: Subcellular Location Annotation
messages: Nucleus

5874:TA16485
gene id: 5874:TA16485
uniprot id: Q4UIX2
names: Subcellular Location Annotation
messages: Nucleus

5874:TA20940
gene id: 5874:TA20940
uniprot id: Q4UGW7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

5874:TA16295
gene id: 5874:TA16295
uniprot id: Q4UIT8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

5874:TA15700
gene id: 5874:TA15700
uniprot id: Q4UFM6
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA10920
gene id: 5874:TA10920
uniprot id: Q4U978
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

5874:TA13070
gene id: 5874:TA13070
uniprot id: Q4UEC2
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

5874:TA10540
gene id: 5874:TA10540
uniprot id: Q4U908
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

5874:TA13855
gene id: 5874:TA13855
uniprot id: Q4UER5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

5874:TA14425
gene id: 5874:TA14425
uniprot id: Q4UF17
names: Subcellular Location Annotation
messages: nucleolus

5874:TA11570
gene id: 5874:TA11570
uniprot id: Q4UDK1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

5874:TA12340
gene id: 5874:TA12340
uniprot id: Q4UDY9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

5874:TA20055
gene id: 5874:TA20055
uniprot id: Q4UG56
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.

5874:TA18690
gene id: 5874:TA18690
uniprot id: Q4UBF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 31 family.
messages: Nucleus

5874:TA11430
gene id: 5874:TA11430
uniprot id: Q4UDH5
names: Similarity
messages: Belongs to the PIGX family.

5874:TA18620
gene id: 5874:TA18620
uniprot id: Q4UBG4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

5874:TA07380
gene id: 5874:TA07380
uniprot id: Q4UA69
names: Similarity
messages: Belongs to the peptidase M67A family.

5874:TA14450
gene id: 5874:TA14450
uniprot id: Q4UF22
names: Similarity
messages: Belongs to the citrate synthase family.

5874:TA08425
gene id: 5874:TA08425
uniprot id: Q4U9M9
names: Subcellular Location Annotation
messages: Cell membrane

5874:TA04200
gene id: 5874:TA04200
uniprot id: Q4UC66
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

5874:TA12110
gene id: 5874:TA12110
uniprot id: Q4UDU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

5874:TA11355
gene id: 5874:TA11355
uniprot id: Q4U8M1
names: Similarity
messages: Belongs to the MGR2 family.

5874:TA14990
gene id: 5874:TA14990
uniprot id: Q4UFW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

5874:TA11270
gene id: 5874:TA11270
uniprot id: Q4U8K4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

5874:TA10120
gene id: 5874:TA10120
uniprot id: Q4U8T2
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

5874:TA03820
gene id: 5874:TA03820
uniprot id: Q4UCX8
names: Similarity
messages: Belongs to the CWC16 family.

5874:TA10535
gene id: 5874:TA10535
uniprot id: Q4U907
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA19785
gene id: 5874:TA19785
uniprot id: Q4UG03
names: Similarity
messages: Belongs to the EXO5 family.

5874:TA09955
gene id: 5874:TA09955
uniprot id: Q4U8Q3
names: Similarity
messages: Belongs to the TRM112 family.

5874:TA08045
gene id: 5874:TA08045
uniprot id: Q4U9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

5874:TA07635
gene id: 5874:TA07635
uniprot id: Q4UA23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

5874:TA08075
gene id: 5874:TA08075
uniprot id: Q4U9U4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA07840
gene id: 5874:TA07840
uniprot id: Q4U9Y6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

5874:TA09515
gene id: 5874:TA09515
uniprot id: Q4UJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

5874:TA03415
gene id: 5874:TA03415
uniprot id: Q4UCL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

5874:TA20595
gene id: 5874:TA20595
uniprot id: Q4UH38
names: Subcellular Location Annotation
messages: Nucleus

5874:TA08060
gene id: 5874:TA08060
uniprot id: Q4UAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

5874:TA19700
gene id: 5874:TA19700
uniprot id: Q4UGK3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

5874:TA13910
gene id: 5874:TA13910
uniprot id: Q4UES5
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

5874:TA06255
gene id: 5874:TA06255
uniprot id: Q4UHP7
names: Similarity
messages: Belongs to the AAA ATPase family.

5874:TA09935
gene id: 5874:TA09935
uniprot id: Q4U8P9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA07535
gene id: 5874:TA07535
uniprot id: Q4UA41
names: Function
names: Subcellular Location Annotation
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane

5874:TA04845
gene id: 5874:TA04845
uniprot id: Q4UBU0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

5874:TA05450
gene id: 5874:TA05450
uniprot id: Q4UCR4
names: Similarity
messages: Belongs to the NARF family.

5874:TA04005
gene id: 5874:TA04005
uniprot id: Q4UCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

5874:TA15515
gene id: 5874:TA15515
uniprot id: Q4UFJ2
names: Similarity
messages: Belongs to the PPP phosphatase family.

5874:TA11695
gene id: 5874:TA11695
uniprot id: Q4UDM3
names: Similarity
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

5874:TA12810
gene id: 5874:TA12810
uniprot id: Q4UE74
names: Similarity
messages: Belongs to the PPC synthetase family.

5874:TA10955
gene id: 5874:TA10955
uniprot id: Q4U985
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA10985
gene id: 5874:TA10985
uniprot id: Q4U989
names: Similarity
messages: Belongs to the cullin family.

5874:TA15335
gene id: 5874:TA15335
uniprot id: Q4UFF9
names: Subcellular Location Annotation
messages: Nucleus

5874:TA12500
gene id: 5874:TA12500
uniprot id: Q4UE19
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

5874:TA13325
gene id: 5874:TA13325
uniprot id: Q4UEG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

5874:TA11070
gene id: 5874:TA11070
uniprot id: Q4U8G4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

5874:TA08325
gene id: 5874:TA08325
uniprot id: Q4U9P7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

5874:TA12460
gene id: 5874:TA12460
uniprot id: Q4UE11
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA07650
gene id: 5874:TA07650
uniprot id: Q4UA19
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

5874:TA11225
gene id: 5874:TA11225
uniprot id: Q4U8J5
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

5874:TA05430
gene id: 5874:TA05430
uniprot id: Q4UCR8
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

5874:TA13750
gene id: 5874:TA13750
uniprot id: Q4UEP5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

5874:TA10625
gene id: 5874:TA10625
uniprot id: Q4U924
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

5874:TA21080
gene id: 5874:TA21080
uniprot id: Q4UGU0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

5874:TA14655
gene id: 5874:TA14655
uniprot id: Q4UF59
names: Similarity
messages: Belongs to the polyprenol kinase family.

5874:TA15270
gene id: 5874:TA15270
uniprot id: Q4UFE8
names: Similarity
messages: Belongs to the PITHD1 family.

5874:TA06995
gene id: 5874:TA06995
uniprot id: Q4UHX0
names: Subcellular Location Annotation
messages: Nucleus

5874:TA08420
gene id: 5874:TA08420
uniprot id: Q4U9N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

5874:TA11255
gene id: 5874:TA11255
uniprot id: Q4U8K1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL21 family.

5874:TA16320
gene id: 5874:TA16320
uniprot id: Q4UIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

5874:TA04750
gene id: 5874:TA04750
uniprot id: Q4UBV8
names: Similarity
messages: Belongs to the SUA5 family.

5874:TA04195
gene id: 5874:TA04195
uniprot id: Q4UC67
names: Subcellular Location Annotation
messages: Membrane

5874:TA10370
gene id: 5874:TA10370
uniprot id: Q4U8X7
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

5874:TA07865
gene id: 5874:TA07865
uniprot id: Q4U9Y1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

5874:TA07935
gene id: 5874:TA07935
uniprot id: Q4U9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

5874:TA03815
gene id: 5874:TA03815
uniprot id: Q4UCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

5874:TA12350
gene id: 5874:TA12350
uniprot id: Q4UDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

5874:TA10250
gene id: 5874:TA10250
uniprot id: Q4U8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

5874:TA03605
gene id: 5874:TA03605
uniprot id: Q4UCH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

5874:TA05670
gene id: 5874:TA05670
uniprot id: Q4UHX9
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

5874:TA12910
gene id: 5874:TA12910
uniprot id: Q4UDB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Nucleus

5874:TA06435
gene id: 5874:TA06435
uniprot id: Q4UIB8
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

5874:TA09950
gene id: 5874:TA09950
uniprot id: Q4U8Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

5874:TA02905
gene id: 5874:TA02905
uniprot id: Q4UHJ3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

5874:TA05445
gene id: 5874:TA05445
uniprot id: Q4UCR5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

5874:TA06230
gene id: 5874:TA06230
uniprot id: Q4UI82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

5874:TA20385
gene id: 5874:TA20385
uniprot id: Q4UH80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

5874:TA18785
gene id: 5874:TA18785
uniprot id: Q4UBD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

5874:TA07365
gene id: 5874:TA07365
uniprot id: Q4UA72
names: Subcellular Location Annotation
messages: Nucleus

5874:TA03745
gene id: 5874:TA03745
uniprot id: Q4UCF2
names: Similarity
messages: Belongs to the peptidase C1 family.

5874:TA21240
gene id: 5874:TA21240
uniprot id: Q4UGQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

5874:TA05720
gene id: 5874:TA05720
uniprot id: Q4UHY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

5874:TA02545
gene id: 5874:TA02545
uniprot id: Q4UD12
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

5874:TA15120
gene id: 5874:TA15120
uniprot id: Q4UFB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

5874:TA17090
gene id: 5874:TA17090
uniprot id: Q4UIQ6
names: Subcellular Location Annotation
messages: Nucleus

5874:TA15850
gene id: 5874:TA15850
uniprot id: Q4UFQ3
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

5874:TA06730
gene id: 5874:TA06730
uniprot id: Q26671
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.
messages: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.
messages: Serine/threonine-protein kinase (By similarity). Involved in the control of the cell cycle. Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).