573063:METIN RS01140
gene id: 573063:METIN_RS01140
uniprot id: D5VQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

573063:METIN RS03795
gene id: 573063:METIN_RS03795
uniprot id: D5VS74
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

573063:METIN RS01670
gene id: 573063:METIN_RS01670
uniprot id: D5VR01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

573063:METIN RS01005
gene id: 573063:METIN_RS01005
uniprot id: D5VQM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

573063:METIN RS03840
gene id: 573063:METIN_RS03840
uniprot id: D5VS81
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

573063:METIN RS03235
gene id: 573063:METIN_RS03235
uniprot id: D5VRW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573063:METIN RS00240
gene id: 573063:METIN_RS00240
uniprot id: D5VUB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

573063:METIN RS02935
gene id: 573063:METIN_RS02935
uniprot id: D5VRQ7
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

573063:METIN RS07290
gene id: 573063:METIN_RS07290
uniprot id: D5VU37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

573063:METIN RS04590
gene id: 573063:METIN_RS04590
uniprot id: D5VSM9
names: Similarity
messages: Belongs to the peptidase S49 family.

573063:METIN RS03380
gene id: 573063:METIN_RS03380
uniprot id: D5VRZ7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS07320
gene id: 573063:METIN_RS07320
uniprot id: D5VU42
names: Similarity
messages: Belongs to the UPF0305 family.

573063:METIN RS03945
gene id: 573063:METIN_RS03945
uniprot id: D5VSA1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

573063:METIN RS01960
gene id: 573063:METIN_RS01960
uniprot id: D5VR58
names: Similarity
messages: Belongs to the TrpC family.

573063:METIN RS04255
gene id: 573063:METIN_RS04255
uniprot id: D5VSG4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

573063:METIN RS03075
gene id: 573063:METIN_RS03075
uniprot id: D5VRT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS00185
gene id: 573063:METIN_RS00185
uniprot id: D5VU99
names: Similarity
messages: Belongs to the P(II) protein family.

573063:METIN RS07085
gene id: 573063:METIN_RS07085
uniprot id: D5VTZ8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

573063:METIN RS01055
gene id: 573063:METIN_RS01055
uniprot id: D5VQN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

573063:METIN RS02295
gene id: 573063:METIN_RS02295
uniprot id: D5VRC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

573063:METIN RS03595
gene id: 573063:METIN_RS03595
uniprot id: D5VS36
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

573063:METIN RS04540
gene id: 573063:METIN_RS04540
uniprot id: D5VSM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

573063:METIN RS03165
gene id: 573063:METIN_RS03165
uniprot id: D5VRV2
names: Similarity
messages: Belongs to the HupF/HypC family.

573063:METIN RS02810
gene id: 573063:METIN_RS02810
uniprot id: D5VRN3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

573063:METIN RS04355
gene id: 573063:METIN_RS04355
uniprot id: D5VSI4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

573063:METIN RS02725
gene id: 573063:METIN_RS02725
uniprot id: D5VRL4
names: Similarity
messages: Belongs to the UPF0201 family.

573063:METIN RS03545
gene id: 573063:METIN_RS03545
uniprot id: D5VS27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

573063:METIN RS02470
gene id: 573063:METIN_RS02470
uniprot id: D5VRG3
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

573063:METIN RS02130
gene id: 573063:METIN_RS02130
uniprot id: D5VR93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

573063:METIN RS05055
gene id: 573063:METIN_RS05055
uniprot id: D5VSW9
names: Similarity
names: Subunit
messages: Belongs to the L-cysteine desulfidase family.
messages: Homotrimer.

573063:METIN RS04180
gene id: 573063:METIN_RS04180
uniprot id: D5VSE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

573063:METIN RS05070
gene id: 573063:METIN_RS05070
uniprot id: D5VSX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

573063:METIN RS02570
gene id: 573063:METIN_RS02570
uniprot id: D5VRI4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

573063:METIN RS03430
gene id: 573063:METIN_RS03430
uniprot id: D5VS07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573063:METIN RS01705
gene id: 573063:METIN_RS01705
uniprot id: D5VR08
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02645
gene id: 573063:METIN_RS02645
uniprot id: D5VRJ9
names: Similarity
messages: Belongs to the ZPR1 family.

573063:METIN RS00265
gene id: 573063:METIN_RS00265
uniprot id: D5VUB5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

573063:METIN RS07275
gene id: 573063:METIN_RS07275
uniprot id: D5VU34
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

573063:METIN RS06580
gene id: 573063:METIN_RS06580
uniprot id: D5VTQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

573063:METIN RS03975
gene id: 573063:METIN_RS03975
uniprot id: D5VSA7
names: Similarity
messages: Belongs to the CutA family.

573063:METIN RS00890
gene id: 573063:METIN_RS00890
uniprot id: D5VQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

573063:METIN RS06120
gene id: 573063:METIN_RS06120
uniprot id: D5VTH4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

573063:METIN RS04910
gene id: 573063:METIN_RS04910
uniprot id: D5VSU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

573063:METIN RS03600
gene id: 573063:METIN_RS03600
uniprot id: D5VS37
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

573063:METIN RS05450
gene id: 573063:METIN_RS05450
uniprot id: D5VT44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573063:METIN RS06350
gene id: 573063:METIN_RS06350
uniprot id: D5VTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

573063:METIN RS02735
gene id: 573063:METIN_RS02735
uniprot id: D5VRL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

573063:METIN RS05790
gene id: 573063:METIN_RS05790
uniprot id: D5VTB0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

573063:METIN RS01680
gene id: 573063:METIN_RS01680
uniprot id: D5VR03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS00600
gene id: 573063:METIN_RS00600
uniprot id: D5VQE2
names: Similarity
messages: Belongs to the UPF0288 family.

573063:METIN RS07240
gene id: 573063:METIN_RS07240
uniprot id: D5VU27
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

573063:METIN RS00125
gene id: 573063:METIN_RS00125
uniprot id: D5VU86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573063:METIN RS04410
gene id: 573063:METIN_RS04410
uniprot id: D5VSJ5
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

573063:METIN RS04810
gene id: 573063:METIN_RS04810
uniprot id: D5VSS0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS03470
gene id: 573063:METIN_RS03470
uniprot id: D5VS14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

573063:METIN RS03690
gene id: 573063:METIN_RS03690
uniprot id: D5VS54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

573063:METIN RS02505
gene id: 573063:METIN_RS02505
uniprot id: D5VRH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS03775
gene id: 573063:METIN_RS03775
uniprot id: D5VS71
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

573063:METIN RS02590
gene id: 573063:METIN_RS02590
uniprot id: D5VRI8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

573063:METIN RS01840
gene id: 573063:METIN_RS01840
uniprot id: D5VR34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS03450
gene id: 573063:METIN_RS03450
uniprot id: D5VS10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

573063:METIN RS04065
gene id: 573063:METIN_RS04065
uniprot id: D5VSC5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

573063:METIN RS03980
gene id: 573063:METIN_RS03980
uniprot id: D5VSA8
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS04740
gene id: 573063:METIN_RS04740
uniprot id: D5VSQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

573063:METIN RS03110
gene id: 573063:METIN_RS03110
uniprot id: D5VRU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS06090
gene id: 573063:METIN_RS06090
uniprot id: D5VTG8
names: Similarity
messages: Belongs to the glutaredoxin family.

573063:METIN RS01910
gene id: 573063:METIN_RS01910
uniprot id: D5VR47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

573063:METIN RS02785
gene id: 573063:METIN_RS02785
uniprot id: D5VRM6
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

573063:METIN RS02010
gene id: 573063:METIN_RS02010
uniprot id: D5VR68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

573063:METIN RS04760
gene id: 573063:METIN_RS04760
uniprot id: D5VSR0
names: Similarity
messages: Belongs to the P(II) protein family.

573063:METIN RS03665
gene id: 573063:METIN_RS03665
uniprot id: D5VS49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573063:METIN RS01540
gene id: 573063:METIN_RS01540
uniprot id: D5VQX5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

573063:METIN RS06535
gene id: 573063:METIN_RS06535
uniprot id: D5VTP7
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS03330
gene id: 573063:METIN_RS03330
uniprot id: D5VRY6
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573063:METIN RS03710
gene id: 573063:METIN_RS03710
uniprot id: D5VS58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS07425
gene id: 573063:METIN_RS07425
uniprot id: D5VU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS00755
gene id: 573063:METIN_RS00755
uniprot id: D5VQH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

573063:METIN RS04285
gene id: 573063:METIN_RS04285
uniprot id: D5VSH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

573063:METIN RS00510
gene id: 573063:METIN_RS00510
uniprot id: D5VQC4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS01780
gene id: 573063:METIN_RS01780
uniprot id: D5VR23
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

573063:METIN RS00520
gene id: 573063:METIN_RS00520
uniprot id: D5VQC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS07200
gene id: 573063:METIN_RS07200
uniprot id: D5VU19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

573063:METIN RS01555
gene id: 573063:METIN_RS01555
uniprot id: D5VQX8
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS05300
gene id: 573063:METIN_RS05300
uniprot id: D5VT16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

573063:METIN RS01730
gene id: 573063:METIN_RS01730
uniprot id: D5VR13
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

573063:METIN RS05425
gene id: 573063:METIN_RS05425
uniprot id: D5VT41
names: Similarity
messages: Belongs to the phosphohexose mutase family.

573063:METIN RS00780
gene id: 573063:METIN_RS00780
uniprot id: D5VQH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

573063:METIN RS06840
gene id: 573063:METIN_RS06840
uniprot id: D5VTV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

573063:METIN RS03465
gene id: 573063:METIN_RS03465
uniprot id: D5VS13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS07280
gene id: 573063:METIN_RS07280
uniprot id: D5VU35
names: Similarity
messages: Belongs to the UPF0282 family.

573063:METIN RS05925
gene id: 573063:METIN_RS05925
uniprot id: D5VTD5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

573063:METIN RS05490
gene id: 573063:METIN_RS05490
uniprot id: D5VT52
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS06105
gene id: 573063:METIN_RS06105
uniprot id: D5VTH1
names: Similarity
messages: Belongs to the UPF0166 family.

573063:METIN RS06745
gene id: 573063:METIN_RS06745
uniprot id: D5VTT8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

573063:METIN RS00075
gene id: 573063:METIN_RS00075
uniprot id: D5VU76
names: Similarity
messages: Belongs to the phosphohexose mutase family.

573063:METIN RS06905
gene id: 573063:METIN_RS06905
uniprot id: D5VTX0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

573063:METIN RS01435
gene id: 573063:METIN_RS01435
uniprot id: D5VQV6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS06815
gene id: 573063:METIN_RS06815
uniprot id: D5VTV2
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

573063:METIN RS05495
gene id: 573063:METIN_RS05495
uniprot id: D5VT53
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS00480
gene id: 573063:METIN_RS00480
uniprot id: D5VQB8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

573063:METIN RS03060
gene id: 573063:METIN_RS03060
uniprot id: D5VRT1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS06210
gene id: 573063:METIN_RS06210
uniprot id: D5VTJ2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

573063:METIN RS06025
gene id: 573063:METIN_RS06025
uniprot id: D5VTF5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

573063:METIN RS04770
gene id: 573063:METIN_RS04770
uniprot id: D5VSR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS02975
gene id: 573063:METIN_RS02975
uniprot id: D5VRR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

573063:METIN RS05335
gene id: 573063:METIN_RS05335
uniprot id: D5VT23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

573063:METIN RS04775
gene id: 573063:METIN_RS04775
uniprot id: D5VSR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

573063:METIN RS00350
gene id: 573063:METIN_RS00350
uniprot id: D5VUD2
names: Similarity
messages: Belongs to the HisA/HisF family.

573063:METIN RS03070
gene id: 573063:METIN_RS03070
uniprot id: D5VRT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

573063:METIN RS02820
gene id: 573063:METIN_RS02820
uniprot id: D5VRN5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

573063:METIN RS03440
gene id: 573063:METIN_RS03440
uniprot id: D5VS08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573063:METIN RS04615
gene id: 573063:METIN_RS04615
uniprot id: D5VSN4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

573063:METIN RS02890
gene id: 573063:METIN_RS02890
uniprot id: D5VRP9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

573063:METIN RS02875
gene id: 573063:METIN_RS02875
uniprot id: D5VRP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS01355
gene id: 573063:METIN_RS01355
uniprot id: D5VQU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS02055
gene id: 573063:METIN_RS02055
uniprot id: D5VR78
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

573063:METIN RS00425
gene id: 573063:METIN_RS00425
uniprot id: D5VQA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS02325
gene id: 573063:METIN_RS02325
uniprot id: D5VRD3
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02220
gene id: 573063:METIN_RS02220
uniprot id: D5VRB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

573063:METIN RS04440
gene id: 573063:METIN_RS04440
uniprot id: D5VSK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

573063:METIN RS06985
gene id: 573063:METIN_RS06985
uniprot id: D5VTY5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

573063:METIN RS03240
gene id: 573063:METIN_RS03240
uniprot id: D5VRW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

573063:METIN RS03920
gene id: 573063:METIN_RS03920
uniprot id: D5VS97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

573063:METIN RS03475
gene id: 573063:METIN_RS03475
uniprot id: D5VS15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

573063:METIN RS03320
gene id: 573063:METIN_RS03320
uniprot id: D5VRY3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

573063:METIN RS06830
gene id: 573063:METIN_RS06830
uniprot id: D5VTV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

573063:METIN RS04735
gene id: 573063:METIN_RS04735
uniprot id: D5VSQ5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

573063:METIN RS06220
gene id: 573063:METIN_RS06220
uniprot id: D5VTJ4
names: Similarity
messages: Belongs to the hemerythrin family.

573063:METIN RS03460
gene id: 573063:METIN_RS03460
uniprot id: D5VS12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

573063:METIN RS01610
gene id: 573063:METIN_RS01610
uniprot id: D5VQY9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

573063:METIN RS03350
gene id: 573063:METIN_RS03350
uniprot id: D5VRZ1
names: Similarity
messages: Belongs to the aspartokinase family.

573063:METIN RS06170
gene id: 573063:METIN_RS06170
uniprot id: D5VTI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS02870
gene id: 573063:METIN_RS02870
uniprot id: D5VRP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

573063:METIN RS06305
gene id: 573063:METIN_RS06305
uniprot id: D5VTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

573063:METIN RS02240
gene id: 573063:METIN_RS02240
uniprot id: D5VRB6
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573063:METIN RS03390
gene id: 573063:METIN_RS03390
uniprot id: D5VRZ9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

573063:METIN RS02245
gene id: 573063:METIN_RS02245
uniprot id: D5VRB7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

573063:METIN RS07180
gene id: 573063:METIN_RS07180
uniprot id: D5VU15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

573063:METIN RS04925
gene id: 573063:METIN_RS04925
uniprot id: D5VSU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573063:METIN RS00535
gene id: 573063:METIN_RS00535
uniprot id: D5VQC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

573063:METIN RS06315
gene id: 573063:METIN_RS06315
uniprot id: D5VTL4
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

573063:METIN RS06990
gene id: 573063:METIN_RS06990
uniprot id: D5VTY6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

573063:METIN RS00680
gene id: 573063:METIN_RS00680
uniprot id: D5VQF8
names: Similarity
messages: Belongs to the P(II) protein family.

573063:METIN RS06480
gene id: 573063:METIN_RS06480
uniprot id: D5VTN6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

573063:METIN RS02780
gene id: 573063:METIN_RS02780
uniprot id: D5VRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

573063:METIN RS02880
gene id: 573063:METIN_RS02880
uniprot id: D5VRP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

573063:METIN RS04710
gene id: 573063:METIN_RS04710
uniprot id: D5VSQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

573063:METIN RS03405
gene id: 573063:METIN_RS03405
uniprot id: D5VS02
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

573063:METIN RS04895
gene id: 573063:METIN_RS04895
uniprot id: D5VST8
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS05580
gene id: 573063:METIN_RS05580
uniprot id: D5VT69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

573063:METIN RS05285
gene id: 573063:METIN_RS05285
uniprot id: D5VT13
names: Similarity
messages: Belongs to the UPF0179 family.

573063:METIN RS04185
gene id: 573063:METIN_RS04185
uniprot id: D5VSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS03695
gene id: 573063:METIN_RS03695
uniprot id: D5VS55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

573063:METIN RS05140
gene id: 573063:METIN_RS05140
uniprot id: D5VSY5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

573063:METIN RS00140
gene id: 573063:METIN_RS00140
uniprot id: D5VU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

573063:METIN RS05810
gene id: 573063:METIN_RS05810
uniprot id: D5VTB4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

573063:METIN RS01575
gene id: 573063:METIN_RS01575
uniprot id: D5VQY2
names: Similarity
messages: Belongs to the UPF0273 family.

573063:METIN RS01760
gene id: 573063:METIN_RS01760
uniprot id: D5VR19
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS00640
gene id: 573063:METIN_RS00640
uniprot id: D5VQE9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

573063:METIN RS05405
gene id: 573063:METIN_RS05405
uniprot id: D5VT37
names: Similarity
messages: Belongs to the UPF0210 family.

573063:METIN RS05870
gene id: 573063:METIN_RS05870
uniprot id: D5VTC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS04000
gene id: 573063:METIN_RS04000
uniprot id: D5VSB2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

573063:METIN RS04155
gene id: 573063:METIN_RS04155
uniprot id: D5VSE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

573063:METIN RS05235
gene id: 573063:METIN_RS05235
uniprot id: D5VT04
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

573063:METIN RS01980
gene id: 573063:METIN_RS01980
uniprot id: D5VR62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

573063:METIN RS01585
gene id: 573063:METIN_RS01585
uniprot id: D5VQY4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

573063:METIN RS00920
gene id: 573063:METIN_RS00920
uniprot id: D5VQK5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

573063:METIN RS01720
gene id: 573063:METIN_RS01720
uniprot id: D5VR11
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS04680
gene id: 573063:METIN_RS04680
uniprot id: D5VSP5
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

573063:METIN RS04780
gene id: 573063:METIN_RS04780
uniprot id: D5VSR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

573063:METIN RS07195
gene id: 573063:METIN_RS07195
uniprot id: D5VU18
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

573063:METIN RS07020
gene id: 573063:METIN_RS07020
uniprot id: D5VTZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

573063:METIN RS00030
gene id: 573063:METIN_RS00030
uniprot id: D5VU67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

573063:METIN RS05035
gene id: 573063:METIN_RS05035
uniprot id: D5VSW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

573063:METIN RS03085
gene id: 573063:METIN_RS03085
uniprot id: D5VRT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

573063:METIN RS00390
gene id: 573063:METIN_RS00390
uniprot id: D5VUE0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

573063:METIN RS00015
gene id: 573063:METIN_RS00015
uniprot id: D5VU64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

573063:METIN RS00205
gene id: 573063:METIN_RS00205
uniprot id: D5VUA3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

573063:METIN RS05560
gene id: 573063:METIN_RS05560
uniprot id: D5VT65
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

573063:METIN RS02595
gene id: 573063:METIN_RS02595
uniprot id: D5VRI9
names: Similarity
messages: Belongs to the alkaline phosphatase family.

573063:METIN RS04220
gene id: 573063:METIN_RS04220
uniprot id: D5VSF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

573063:METIN RS02860
gene id: 573063:METIN_RS02860
uniprot id: D5VRP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

573063:METIN RS06175
gene id: 573063:METIN_RS06175
uniprot id: D5VTI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS01880
gene id: 573063:METIN_RS01880
uniprot id: D5VR41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

573063:METIN RS01470
gene id: 573063:METIN_RS01470
uniprot id: D5VQW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS05085
gene id: 573063:METIN_RS05085
uniprot id: D5VSX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

573063:METIN RS00220
gene id: 573063:METIN_RS00220
uniprot id: D5VUA6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

573063:METIN RS01895
gene id: 573063:METIN_RS01895
uniprot id: D5VR44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

573063:METIN RS03410
gene id: 573063:METIN_RS03410
uniprot id: D5VS03
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS04875
gene id: 573063:METIN_RS04875
uniprot id: D5VST4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

573063:METIN RS01425
gene id: 573063:METIN_RS01425
uniprot id: D5VQV4
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

573063:METIN RS06010
gene id: 573063:METIN_RS06010
uniprot id: D5VTF2
names: Function
messages: Part of a potassium transport system.

573063:METIN RS05395
gene id: 573063:METIN_RS05395
uniprot id: D5VT35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

573063:METIN RS01015
gene id: 573063:METIN_RS01015
uniprot id: D5VQM4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

573063:METIN RS05400
gene id: 573063:METIN_RS05400
uniprot id: D5VT36
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

573063:METIN RS01255
gene id: 573063:METIN_RS01255
uniprot id: D5VQS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

573063:METIN RS02805
gene id: 573063:METIN_RS02805
uniprot id: D5VRN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

573063:METIN RS03800
gene id: 573063:METIN_RS03800
uniprot id: D5VS75
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS04345
gene id: 573063:METIN_RS04345
uniprot id: D5VSI2
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

573063:METIN RS03355
gene id: 573063:METIN_RS03355
uniprot id: D5VRZ2
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

573063:METIN RS03905
gene id: 573063:METIN_RS03905
uniprot id: D5VS94
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

573063:METIN RS07190
gene id: 573063:METIN_RS07190
uniprot id: D5VU17
names: Similarity
messages: Belongs to the PstS family.

573063:METIN RS02565
gene id: 573063:METIN_RS02565
uniprot id: D5VRI3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

573063:METIN RS06045
gene id: 573063:METIN_RS06045
uniprot id: D5VTF9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS03055
gene id: 573063:METIN_RS03055
uniprot id: D5VRT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS05660
gene id: 573063:METIN_RS05660
uniprot id: D5VT85
names: Similarity
messages: Belongs to the FwdC/FmdC family.

573063:METIN RS06445
gene id: 573063:METIN_RS06445
uniprot id: D5VTM9
names: Similarity
messages: Belongs to the UPF0248 family.

573063:METIN RS05295
gene id: 573063:METIN_RS05295
uniprot id: D5VT15
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

573063:METIN RS03230
gene id: 573063:METIN_RS03230
uniprot id: D5VRW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

573063:METIN RS02185
gene id: 573063:METIN_RS02185
uniprot id: D5VRA6
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02510
gene id: 573063:METIN_RS02510
uniprot id: D5VRH1
names: Similarity
messages: Belongs to the SDO1/SBDS family.

573063:METIN RS04595
gene id: 573063:METIN_RS04595
uniprot id: D5VSN0
names: Similarity
messages: Belongs to the peptidase C56 family.

573063:METIN RS03090
gene id: 573063:METIN_RS03090
uniprot id: D5VRT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS02235
gene id: 573063:METIN_RS02235
uniprot id: D5VRB5
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573063:METIN RS01545
gene id: 573063:METIN_RS01545
uniprot id: D5VQX6
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02350
gene id: 573063:METIN_RS02350
uniprot id: D5VRD8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573063:METIN RS04750
gene id: 573063:METIN_RS04750
uniprot id: D5VSQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

573063:METIN RS05680
gene id: 573063:METIN_RS05680
uniprot id: D5VT89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

573063:METIN RS03830
gene id: 573063:METIN_RS03830
uniprot id: D5VS80
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

573063:METIN RS01310
gene id: 573063:METIN_RS01310
uniprot id: D5VQT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

573063:METIN RS05455
gene id: 573063:METIN_RS05455
uniprot id: D5VT45
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02865
gene id: 573063:METIN_RS02865
uniprot id: D5VRP4
names: Similarity
messages: Belongs to the UPF0212 family.

573063:METIN RS07300
gene id: 573063:METIN_RS07300
uniprot id: D5VU38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

573063:METIN RS03615
gene id: 573063:METIN_RS03615
uniprot id: D5VS40
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

573063:METIN RS00635
gene id: 573063:METIN_RS00635
uniprot id: D5VQE8
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

573063:METIN RS06765
gene id: 573063:METIN_RS06765
uniprot id: D5VTU2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

573063:METIN RS02155
gene id: 573063:METIN_RS02155
uniprot id: D5VR99
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

573063:METIN RS05180
gene id: 573063:METIN_RS05180
uniprot id: D5VSZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

573063:METIN RS04160
gene id: 573063:METIN_RS04160
uniprot id: D5VSE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

573063:METIN RS04465
gene id: 573063:METIN_RS04465
uniprot id: D5VSK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

573063:METIN RS04990
gene id: 573063:METIN_RS04990
uniprot id: D5VSV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

573063:METIN RS00395
gene id: 573063:METIN_RS00395
uniprot id: D5VUE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

573063:METIN RS05795
gene id: 573063:METIN_RS05795
uniprot id: D5VTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

573063:METIN RS06680
gene id: 573063:METIN_RS06680
uniprot id: D5VTS5
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02075
gene id: 573063:METIN_RS02075
uniprot id: D5VR82
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

573063:METIN RS03270
gene id: 573063:METIN_RS03270
uniprot id: D5VRX3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

573063:METIN RS01135
gene id: 573063:METIN_RS01135
uniprot id: D5VQP8
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS03420
gene id: 573063:METIN_RS03420
uniprot id: D5VS05
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS01445
gene id: 573063:METIN_RS01445
uniprot id: D5VQV8
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

573063:METIN RS03175
gene id: 573063:METIN_RS03175
uniprot id: D5VRV4
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS01525
gene id: 573063:METIN_RS01525
uniprot id: D5VQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573063:METIN RS02775
gene id: 573063:METIN_RS02775
uniprot id: D5VRM4
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

573063:METIN RS04625
gene id: 573063:METIN_RS04625
uniprot id: D5VSN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

573063:METIN RS01650
gene id: 573063:METIN_RS01650
uniprot id: D5VQZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS01595
gene id: 573063:METIN_RS01595
uniprot id: D5VQY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS02730
gene id: 573063:METIN_RS02730
uniprot id: D5VRL5
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS03190
gene id: 573063:METIN_RS03190
uniprot id: D5VRV7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS00935
gene id: 573063:METIN_RS00935
uniprot id: D5VQK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

573063:METIN RS03745
gene id: 573063:METIN_RS03745
uniprot id: D5VS65
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

573063:METIN RS02360
gene id: 573063:METIN_RS02360
uniprot id: D5VRE1
names: Similarity
messages: Belongs to the UPF0235 family.

573063:METIN RS04490
gene id: 573063:METIN_RS04490
uniprot id: D5VSL3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

573063:METIN RS01565
gene id: 573063:METIN_RS01565
uniprot id: D5VQY0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

573063:METIN RS02440
gene id: 573063:METIN_RS02440
uniprot id: D5VRF7
names: Subunit
messages: Homotetramer.

573063:METIN RS01210
gene id: 573063:METIN_RS01210
uniprot id: D5VQR1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

573063:METIN RS01420
gene id: 573063:METIN_RS01420
uniprot id: D5VQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

573063:METIN RS02915
gene id: 573063:METIN_RS02915
uniprot id: D5VRQ3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

573063:METIN RS06185
gene id: 573063:METIN_RS06185
uniprot id: D5VTI8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS03150
gene id: 573063:METIN_RS03150
uniprot id: D5VRU9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

573063:METIN RS05545
gene id: 573063:METIN_RS05545
uniprot id: D5VT62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

573063:METIN RS00475
gene id: 573063:METIN_RS00475
uniprot id: D5VQB7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

573063:METIN RS00615
gene id: 573063:METIN_RS00615
uniprot id: D5VQE5
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

573063:METIN RS01020
gene id: 573063:METIN_RS01020
uniprot id: D5VQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

573063:METIN RS02515
gene id: 573063:METIN_RS02515
uniprot id: D5VRH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

573063:METIN RS02460
gene id: 573063:METIN_RS02460
uniprot id: D5VRG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573063:METIN RS03125
gene id: 573063:METIN_RS03125
uniprot id: D5VRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573063:METIN RS05365
gene id: 573063:METIN_RS05365
uniprot id: D5VT29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

573063:METIN RS04635
gene id: 573063:METIN_RS04635
uniprot id: D5VSN7
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

573063:METIN RS00545
gene id: 573063:METIN_RS00545
uniprot id: D5VQD1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

573063:METIN RS01350
gene id: 573063:METIN_RS01350
uniprot id: D5VQT9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

573063:METIN RS02070
gene id: 573063:METIN_RS02070
uniprot id: D5VR81
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS00710
gene id: 573063:METIN_RS00710
uniprot id: D5VQG4
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS05225
gene id: 573063:METIN_RS05225
uniprot id: D5VT02
names: Similarity
messages: Belongs to the MoaB/Mog family.

573063:METIN RS05415
gene id: 573063:METIN_RS05415
uniprot id: D5VT39
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS06110
gene id: 573063:METIN_RS06110
uniprot id: D5VTH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

573063:METIN RS02095
gene id: 573063:METIN_RS02095
uniprot id: D5VR86
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

573063:METIN RS01600
gene id: 573063:METIN_RS01600
uniprot id: D5VQY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS02410
gene id: 573063:METIN_RS02410
uniprot id: D5VRF1
names: Similarity
messages: Belongs to the AAA ATPase family.

573063:METIN RS04865
gene id: 573063:METIN_RS04865
uniprot id: D5VST2
names: Similarity
messages: Belongs to the NodU/CmcH family.

573063:METIN RS00620
gene id: 573063:METIN_RS00620
uniprot id: D5VQE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

573063:METIN RS04520
gene id: 573063:METIN_RS04520
uniprot id: D5VSL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

573063:METIN RS05000
gene id: 573063:METIN_RS05000
uniprot id: D5VSV8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

573063:METIN RS02970
gene id: 573063:METIN_RS02970
uniprot id: D5VRR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

573063:METIN RS04245
gene id: 573063:METIN_RS04245
uniprot id: D5VSG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

573063:METIN RS03765
gene id: 573063:METIN_RS03765
uniprot id: D5VS69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

573063:METIN RS04195
gene id: 573063:METIN_RS04195
uniprot id: D5VSF2
names: Similarity
messages: Belongs to the UPF0310 family.

573063:METIN RS07025
gene id: 573063:METIN_RS07025
uniprot id: D5VTZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

573063:METIN RS04945
gene id: 573063:METIN_RS04945
uniprot id: D5VSU9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

573063:METIN RS01370
gene id: 573063:METIN_RS01370
uniprot id: D5VQU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS05625
gene id: 573063:METIN_RS05625
uniprot id: D5VT78
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

573063:METIN RS01485
gene id: 573063:METIN_RS01485
uniprot id: D5VQW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

573063:METIN RS00730
gene id: 573063:METIN_RS00730
uniprot id: D5VQG8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS02395
gene id: 573063:METIN_RS02395
uniprot id: D5VRE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS02345
gene id: 573063:METIN_RS02345
uniprot id: D5VRD7
names: Similarity
messages: Belongs to the DMRL synthase family.

573063:METIN RS06450
gene id: 573063:METIN_RS06450
uniprot id: D5VTN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

573063:METIN RS06810
gene id: 573063:METIN_RS06810
uniprot id: D5VTV1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

573063:METIN RS01450
gene id: 573063:METIN_RS01450
uniprot id: D5VQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

573063:METIN RS03080
gene id: 573063:METIN_RS03080
uniprot id: D5VRT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

573063:METIN RS02255
gene id: 573063:METIN_RS02255
uniprot id: D5VRB9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:25151136, PubMed:30733442). The proposed mechanism is the following: (i) recruits S-adenosyl-L-methionine and cleaves it to generate a 5'-deoxyadenosine radical (5'-dA) in the radical S-adenosyl-L-methionine (rSAM) region, (ii) hydrolyzes acetyl-CoA in the N-acetyltransferase domain and (iii) an acetyl radical is formed by the products of the two domains and (iv) is transferred onto the C5 position of uridine(34) in the bound tRNA molecule (PubMed:25151136). Does not show protein lysine acetyltransferase activity (PubMed:30733442).

573063:METIN RS05615
gene id: 573063:METIN_RS05615
uniprot id: D5VT76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

573063:METIN RS01695
gene id: 573063:METIN_RS01695
uniprot id: D5VR06
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

573063:METIN RS03585
gene id: 573063:METIN_RS03585
uniprot id: D5VS34
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

573063:METIN RS04960
gene id: 573063:METIN_RS04960
uniprot id: D5VSV3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573063:METIN RS05305
gene id: 573063:METIN_RS05305
uniprot id: D5VT17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

573063:METIN RS02015
gene id: 573063:METIN_RS02015
uniprot id: D5VR69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

573063:METIN RS00195
gene id: 573063:METIN_RS00195
uniprot id: D5VUA1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-108 inactivates the nitrogenase reductase and regulates nitrogenase activity.

573063:METIN RS02610
gene id: 573063:METIN_RS02610
uniprot id: D5VRJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

573063:METIN RS03115
gene id: 573063:METIN_RS03115
uniprot id: D5VRU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

573063:METIN RS05830
gene id: 573063:METIN_RS05830
uniprot id: D5VTB6
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

573063:METIN RS02855
gene id: 573063:METIN_RS02855
uniprot id: D5VRP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

573063:METIN RS04650
gene id: 573063:METIN_RS04650
uniprot id: D5VSP0
names: Similarity
messages: Belongs to the MEMO1 family.

573063:METIN RS02630
gene id: 573063:METIN_RS02630
uniprot id: D5VRJ6
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

573063:METIN RS04880
gene id: 573063:METIN_RS04880
uniprot id: D5VSB5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

573063:METIN RS03285
gene id: 573063:METIN_RS03285
uniprot id: D5VRX6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

573063:METIN RS07030
gene id: 573063:METIN_RS07030
uniprot id: D5VTZ3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

573063:METIN RS04075
gene id: 573063:METIN_RS04075
uniprot id: D5VSC7
names: Similarity
messages: Belongs to the HerA family.

573063:METIN RS01375
gene id: 573063:METIN_RS01375
uniprot id: D5VQU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS01725
gene id: 573063:METIN_RS01725
uniprot id: D5VR12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573063:METIN RS00540
gene id: 573063:METIN_RS00540
uniprot id: D5VQD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

573063:METIN RS00295
gene id: 573063:METIN_RS00295
uniprot id: D5VUC1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

573063:METIN RS02940
gene id: 573063:METIN_RS02940
uniprot id: D5VRQ8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

573063:METIN RS03575
gene id: 573063:METIN_RS03575
uniprot id: D5VS32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573063:METIN RS04050
gene id: 573063:METIN_RS04050
uniprot id: D5VSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

573063:METIN RS00585
gene id: 573063:METIN_RS00585
uniprot id: D5VQD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

573063:METIN RS02305
gene id: 573063:METIN_RS02305
uniprot id: D5VRC9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

573063:METIN RS06320
gene id: 573063:METIN_RS06320
uniprot id: D5VTL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

573063:METIN RS03660
gene id: 573063:METIN_RS03660
uniprot id: D5VS48
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

573063:METIN RS02115
gene id: 573063:METIN_RS02115
uniprot id: D5VR90
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

573063:METIN RS06100
gene id: 573063:METIN_RS06100
uniprot id: D5VTH0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

573063:METIN RS01380
gene id: 573063:METIN_RS01380
uniprot id: D5VQU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS03785
gene id: 573063:METIN_RS03785
uniprot id: D5VS73
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS00830
gene id: 573063:METIN_RS00830
uniprot id: D5VQI8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS04005
gene id: 573063:METIN_RS04005
uniprot id: D5VSB3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

573063:METIN RS00595
gene id: 573063:METIN_RS00595
uniprot id: D5VQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

573063:METIN RS03880
gene id: 573063:METIN_RS03880
uniprot id: D5VS89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573063:METIN RS02760
gene id: 573063:METIN_RS02760
uniprot id: D5VRM1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Binds 3 [4Fe-4S] clusters per monomer. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. The two others probably act as substrate.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms (PubMed:27268267). NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster (PubMed:27268267, PubMed:26969410).
messages: Monomer.

573063:METIN RS04885
gene id: 573063:METIN_RS04885
uniprot id: D5VST6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

573063:METIN RS07305
gene id: 573063:METIN_RS07305
uniprot id: D5VU39
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS05240
gene id: 573063:METIN_RS05240
uniprot id: D5VT05
names: Similarity
messages: Belongs to the MCM family.

573063:METIN RS02740
gene id: 573063:METIN_RS02740
uniprot id: D5VRL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

573063:METIN RS04930
gene id: 573063:METIN_RS04930
uniprot id: D5VSU6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

573063:METIN RS03335
gene id: 573063:METIN_RS03335
uniprot id: D5VRY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

573063:METIN RS05465
gene id: 573063:METIN_RS05465
uniprot id: D5VT47
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

573063:METIN RS01050
gene id: 573063:METIN_RS01050
uniprot id: D5VQN1
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

573063:METIN RS06475
gene id: 573063:METIN_RS06475
uniprot id: D5VTN5
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS06920
gene id: 573063:METIN_RS06920
uniprot id: D5VTX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573063:METIN RS00470
gene id: 573063:METIN_RS00470
uniprot id: D5VQB6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS03200
gene id: 573063:METIN_RS03200
uniprot id: D5VRV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573063:METIN RS02400
gene id: 573063:METIN_RS02400
uniprot id: D5VRE9
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

573063:METIN RS00685
gene id: 573063:METIN_RS00685
uniprot id: D5VQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

573063:METIN RS06975
gene id: 573063:METIN_RS06975
uniprot id: D5VTY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

573063:METIN RS03670
gene id: 573063:METIN_RS03670
uniprot id: D5VS50
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

573063:METIN RS03455
gene id: 573063:METIN_RS03455
uniprot id: D5VS11
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

573063:METIN RS01870
gene id: 573063:METIN_RS01870
uniprot id: D5VR39
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573063:METIN RS02335
gene id: 573063:METIN_RS02335
uniprot id: D5VRD5
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS04575
gene id: 573063:METIN_RS04575
uniprot id: D5VSM6
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

573063:METIN RS04270
gene id: 573063:METIN_RS04270
uniprot id: D5VSG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

573063:METIN RS00400
gene id: 573063:METIN_RS00400
uniprot id: D5VQA1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS04525
gene id: 573063:METIN_RS04525
uniprot id: D5VSM0
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

573063:METIN RS05485
gene id: 573063:METIN_RS05485
uniprot id: D5VT51
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

573063:METIN RS05360
gene id: 573063:METIN_RS05360
uniprot id: D5VT28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

573063:METIN RS00700
gene id: 573063:METIN_RS00700
uniprot id: D5VQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

573063:METIN RS05770
gene id: 573063:METIN_RS05770
uniprot id: D5VTA6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

573063:METIN RS01820
gene id: 573063:METIN_RS01820
uniprot id: D5VR30
names: Similarity
messages: Belongs to the UPF0146 family.

573063:METIN RS05385
gene id: 573063:METIN_RS05385
uniprot id: D5VT33
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

573063:METIN RS06215
gene id: 573063:METIN_RS06215
uniprot id: D5VTJ3
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

573063:METIN RS03415
gene id: 573063:METIN_RS03415
uniprot id: D5VS04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

573063:METIN RS04545
gene id: 573063:METIN_RS04545
uniprot id: D5VSM4
names: Similarity
messages: Belongs to the HMBS family.

573063:METIN RS03120
gene id: 573063:METIN_RS03120
uniprot id: D5VRU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS00290
gene id: 573063:METIN_RS00290
uniprot id: D5VUC0
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS06420
gene id: 573063:METIN_RS06420
uniprot id: D5VTM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

573063:METIN RS01520
gene id: 573063:METIN_RS01520
uniprot id: D5VQX1
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS07210
gene id: 573063:METIN_RS07210
uniprot id: D5VU21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573063:METIN RS05885
gene id: 573063:METIN_RS05885
uniprot id: D5VTC7
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS02960
gene id: 573063:METIN_RS02960
uniprot id: D5VRR2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

573063:METIN RS03640
gene id: 573063:METIN_RS03640
uniprot id: D5VS45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

573063:METIN RS06410
gene id: 573063:METIN_RS06410
uniprot id: D5VTM2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS04480
gene id: 573063:METIN_RS04480
uniprot id: D5VSL0
names: Similarity
messages: Belongs to the AAA ATPase family.

573063:METIN RS02490
gene id: 573063:METIN_RS02490
uniprot id: D5VRG7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

573063:METIN RS03370
gene id: 573063:METIN_RS03370
uniprot id: D5VRZ5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

573063:METIN RS04325
gene id: 573063:METIN_RS04325
uniprot id: D5VSH8
names: Similarity
messages: Belongs to the glutamate synthase family.

573063:METIN RS00405
gene id: 573063:METIN_RS00405
uniprot id: D5VQA2
names: Similarity
messages: Belongs to the UPF0173 family.

573063:METIN RS02105
gene id: 573063:METIN_RS02105
uniprot id: D5VR88
names: Subunit
messages: Homotetramer.

573063:METIN RS04295
gene id: 573063:METIN_RS04295
uniprot id: D5VSH2
names: Similarity
messages: Belongs to the thymidylate kinase family.

573063:METIN RS00855
gene id: 573063:METIN_RS00855
uniprot id: D5VQJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

573063:METIN RS03360
gene id: 573063:METIN_RS03360
uniprot id: D5VRZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

573063:METIN RS01360
gene id: 573063:METIN_RS01360
uniprot id: D5VQU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS00115
gene id: 573063:METIN_RS00115
uniprot id: D5VU84
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS00190
gene id: 573063:METIN_RS00190
uniprot id: D5VUA0
names: Similarity
messages: Belongs to the P(II) protein family.

573063:METIN RS06015
gene id: 573063:METIN_RS06015
uniprot id: D5VTF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

573063:METIN RS01805
gene id: 573063:METIN_RS01805
uniprot id: D5VR28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

573063:METIN RS04095
gene id: 573063:METIN_RS04095
uniprot id: D5VSD1
names: Similarity
messages: Belongs to the UPF0047 family.

573063:METIN RS00760
gene id: 573063:METIN_RS00760
uniprot id: D5VQH4
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS00180
gene id: 573063:METIN_RS00180
uniprot id: D5VU98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

573063:METIN RS02265
gene id: 573063:METIN_RS02265
uniprot id: D5VRC1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

573063:METIN RS02795
gene id: 573063:METIN_RS02795
uniprot id: D5VRM9
names: Similarity
messages: Belongs to the UPF0200 family.

573063:METIN RS07285
gene id: 573063:METIN_RS07285
uniprot id: D5VU36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS07010
gene id: 573063:METIN_RS07010
uniprot id: D5VTY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

573063:METIN RS07315
gene id: 573063:METIN_RS07315
uniprot id: D5VU41
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS03375
gene id: 573063:METIN_RS03375
uniprot id: D5VRZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

573063:METIN RS01290
gene id: 573063:METIN_RS01290
uniprot id: D5VQS7
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

573063:METIN RS04765
gene id: 573063:METIN_RS04765
uniprot id: D5VSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

573063:METIN RS04830
gene id: 573063:METIN_RS04830
uniprot id: D5VSS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS05315
gene id: 573063:METIN_RS05315
uniprot id: D5VT19
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS02995
gene id: 573063:METIN_RS02995
uniprot id: D5VRR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

573063:METIN RS03890
gene id: 573063:METIN_RS03890
uniprot id: D5VS91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

573063:METIN RS03875
gene id: 573063:METIN_RS03875
uniprot id: D5VS88
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

573063:METIN RS04310
gene id: 573063:METIN_RS04310
uniprot id: D5VSH5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

573063:METIN RS04070
gene id: 573063:METIN_RS04070
uniprot id: D5VSC6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

573063:METIN RS05410
gene id: 573063:METIN_RS05410
uniprot id: D5VT38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

573063:METIN RS03035
gene id: 573063:METIN_RS03035
uniprot id: D5VRS7
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02550
gene id: 573063:METIN_RS02550
uniprot id: D5VRI0
names: Similarity
messages: Belongs to the FrhG family.

573063:METIN RS05685
gene id: 573063:METIN_RS05685
uniprot id: D5VT90
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS03255
gene id: 573063:METIN_RS03255
uniprot id: D5VRX0
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

573063:METIN RS02420
gene id: 573063:METIN_RS02420
uniprot id: D5VRF3
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS03515
gene id: 573063:METIN_RS03515
uniprot id: D5VS21
names: Similarity
messages: Belongs to the UPF0285 family.

573063:METIN RS02690
gene id: 573063:METIN_RS02690
uniprot id: D5VRK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573063:METIN RS07365
gene id: 573063:METIN_RS07365
uniprot id: D5VU51
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

573063:METIN RS00360
gene id: 573063:METIN_RS00360
uniprot id: D5VUD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573063:METIN RS04200
gene id: 573063:METIN_RS04200
uniprot id: D5VSF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

573063:METIN RS04080
gene id: 573063:METIN_RS04080
uniprot id: D5VSC8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

573063:METIN RS02005
gene id: 573063:METIN_RS02005
uniprot id: D5VR67
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS05900
gene id: 573063:METIN_RS05900
uniprot id: D5VTD0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

573063:METIN RS01515
gene id: 573063:METIN_RS01515
uniprot id: D5VQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

573063:METIN RS04630
gene id: 573063:METIN_RS04630
uniprot id: D5VSN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

573063:METIN RS03315
gene id: 573063:METIN_RS03315
uniprot id: D5VRY2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

573063:METIN RS03760
gene id: 573063:METIN_RS03760
uniprot id: D5VS68
names: Similarity
messages: Belongs to the LarC family.

573063:METIN RS07625
gene id: 573063:METIN_RS07625
uniprot id: D5VQJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

573063:METIN RS02385
gene id: 573063:METIN_RS02385
uniprot id: D5VRE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

573063:METIN RS06755
gene id: 573063:METIN_RS06755
uniprot id: D5VTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

573063:METIN RS02340
gene id: 573063:METIN_RS02340
uniprot id: D5VRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

573063:METIN RS06835
gene id: 573063:METIN_RS06835
uniprot id: D5VTV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

573063:METIN RS04825
gene id: 573063:METIN_RS04825
uniprot id: D5VSS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

573063:METIN RS00035
gene id: 573063:METIN_RS00035
uniprot id: D5VU68
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

573063:METIN RS05340
gene id: 573063:METIN_RS05340
uniprot id: D5VT24
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

573063:METIN RS05970
gene id: 573063:METIN_RS05970
uniprot id: D5VTE4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

573063:METIN RS04390
gene id: 573063:METIN_RS04390
uniprot id: D5VSJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

573063:METIN RS01400
gene id: 573063:METIN_RS01400
uniprot id: D5VQU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

573063:METIN RS05785
gene id: 573063:METIN_RS05785
uniprot id: D5VTA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

573063:METIN RS04090
gene id: 573063:METIN_RS04090
uniprot id: D5VSD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

573063:METIN RS00370
gene id: 573063:METIN_RS00370
uniprot id: D5VUD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

573063:METIN RS04695
gene id: 573063:METIN_RS04695
uniprot id: D5VSP8
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

573063:METIN RS03895
gene id: 573063:METIN_RS03895
uniprot id: D5VS92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

573063:METIN RS04340
gene id: 573063:METIN_RS04340
uniprot id: D5VSI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

573063:METIN RS02790
gene id: 573063:METIN_RS02790
uniprot id: D5VRM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

573063:METIN RS00420
gene id: 573063:METIN_RS00420
uniprot id: D5VQA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

573063:METIN RS04015
gene id: 573063:METIN_RS04015
uniprot id: D5VSB5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

573063:METIN RS07005
gene id: 573063:METIN_RS07005
uniprot id: D5VTY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS00280
gene id: 573063:METIN_RS00280
uniprot id: D5VUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

573063:METIN RS07160
gene id: 573063:METIN_RS07160
uniprot id: D5VU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573063:METIN RS07015
gene id: 573063:METIN_RS07015
uniprot id: D5VTZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

573063:METIN RS04120
gene id: 573063:METIN_RS04120
uniprot id: D5VSD6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

573063:METIN RS03215
gene id: 573063:METIN_RS03215
uniprot id: D5VRW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

573063:METIN RS02175
gene id: 573063:METIN_RS02175
uniprot id: D5VRA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

573063:METIN RS06330
gene id: 573063:METIN_RS06330
uniprot id: D5VTL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

573063:METIN RS00080
gene id: 573063:METIN_RS00080
uniprot id: D5VU77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

573063:METIN RS06935
gene id: 573063:METIN_RS06935
uniprot id: D5VTX6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

573063:METIN RS02885
gene id: 573063:METIN_RS02885
uniprot id: D5VRP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

573063:METIN RS03105
gene id: 573063:METIN_RS03105
uniprot id: D5VRU0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

573063:METIN RS06285
gene id: 573063:METIN_RS06285
uniprot id: D5VTK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

573063:METIN RS02090
gene id: 573063:METIN_RS02090
uniprot id: D5VR85
names: Similarity
messages: Belongs to the DtxR/MntR family.

573063:METIN RS02110
gene id: 573063:METIN_RS02110
uniprot id: D5VR89
names: Similarity
messages: Belongs to the UPF0147 family.

573063:METIN RS05325
gene id: 573063:METIN_RS05325
uniprot id: D5VT21
names: Similarity
messages: Belongs to the UPF0254 family.

573063:METIN RS01160
gene id: 573063:METIN_RS01160
uniprot id: D5VQQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

573063:METIN RS05460
gene id: 573063:METIN_RS05460
uniprot id: D5VT46
names: Similarity
messages: Belongs to the HMD family.

573063:METIN RS06730
gene id: 573063:METIN_RS06730
uniprot id: D5VTT5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

573063:METIN RS02045
gene id: 573063:METIN_RS02045
uniprot id: D5VR76
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

573063:METIN RS03385
gene id: 573063:METIN_RS03385
uniprot id: D5VRZ8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

573063:METIN RS04915
gene id: 573063:METIN_RS04915
uniprot id: D5VSU3
names: Similarity
messages: Belongs to the peptidase U62 family.

573063:METIN RS04505
gene id: 573063:METIN_RS04505
uniprot id: D5VSL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

573063:METIN RS03280
gene id: 573063:METIN_RS03280
uniprot id: D5VRX5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

573063:METIN RS06150
gene id: 573063:METIN_RS06150
uniprot id: D5VTI0
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

573063:METIN RS06075
gene id: 573063:METIN_RS06075
uniprot id: D5VTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

573063:METIN RS04795
gene id: 573063:METIN_RS04795
uniprot id: D5VSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573063:METIN RS00550
gene id: 573063:METIN_RS00550
uniprot id: D5VQD2
names: Similarity
messages: Belongs to the TPP enzyme family.

573063:METIN RS05865
gene id: 573063:METIN_RS05865
uniprot id: D5VTC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS07255
gene id: 573063:METIN_RS07255
uniprot id: D5VU30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

573063:METIN RS05670
gene id: 573063:METIN_RS05670
uniprot id: D5VT87
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

573063:METIN RS04730
gene id: 573063:METIN_RS04730
uniprot id: D5VSQ4
names: Similarity
messages: Belongs to the class-I fumarase family.

573063:METIN RS06855
gene id: 573063:METIN_RS06855
uniprot id: D5VTW0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

573063:METIN RS04725
gene id: 573063:METIN_RS04725
uniprot id: D5VSQ3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

573063:METIN RS01390
gene id: 573063:METIN_RS01390
uniprot id: D5VQU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS02300
gene id: 573063:METIN_RS02300
uniprot id: D5VRC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

573063:METIN RS02955
gene id: 573063:METIN_RS02955
uniprot id: D5VRR1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

573063:METIN RS00880
gene id: 573063:METIN_RS00880
uniprot id: D5VQJ7
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS05775
gene id: 573063:METIN_RS05775
uniprot id: D5VTA7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

573063:METIN RS04025
gene id: 573063:METIN_RS04025
uniprot id: D5VSB7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

573063:METIN RS03750
gene id: 573063:METIN_RS03750
uniprot id: D5VS66
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

573063:METIN RS00835
gene id: 573063:METIN_RS00835
uniprot id: D5VQI9
names: Similarity
messages: Belongs to the UPF0215 family.

573063:METIN RS06805
gene id: 573063:METIN_RS06805
uniprot id: D5VTV0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

573063:METIN RS00735
gene id: 573063:METIN_RS00735
uniprot id: D5VQG9
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

573063:METIN RS05255
gene id: 573063:METIN_RS05255
uniprot id: D5VT08
names: Similarity
messages: Belongs to the UPF0280 family.

573063:METIN RS00245
gene id: 573063:METIN_RS00245
uniprot id: D5VUB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

573063:METIN RS04685
gene id: 573063:METIN_RS04685
uniprot id: D5VSP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573063:METIN RS04605
gene id: 573063:METIN_RS04605
uniprot id: D5VSN2
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

573063:METIN RS02270
gene id: 573063:METIN_RS02270
uniprot id: D5VRC2
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

573063:METIN RS01395
gene id: 573063:METIN_RS01395
uniprot id: D5VQU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

573063:METIN RS05355
gene id: 573063:METIN_RS05355
uniprot id: D5VT27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

573063:METIN RS00065
gene id: 573063:METIN_RS00065
uniprot id: D5VU74
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS06910
gene id: 573063:METIN_RS06910
uniprot id: D5VTX1
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS04785
gene id: 573063:METIN_RS04785
uniprot id: D5VSR5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

573063:METIN RS03130
gene id: 573063:METIN_RS03130
uniprot id: D5VRU5
names: Similarity
messages: Belongs to the SUI1 family.

573063:METIN RS01080
gene id: 573063:METIN_RS01080
uniprot id: D5VQN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573063:METIN RS00260
gene id: 573063:METIN_RS00260
uniprot id: D5VUB4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

573063:METIN RS02150
gene id: 573063:METIN_RS02150
uniprot id: D5VR98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

573063:METIN RS00255
gene id: 573063:METIN_RS00255
uniprot id: D5VUB3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

573063:METIN RS01755
gene id: 573063:METIN_RS01755
uniprot id: D5VR18
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS03630
gene id: 573063:METIN_RS03630
uniprot id: D5VS43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

573063:METIN RS06440
gene id: 573063:METIN_RS06440
uniprot id: D5VTM8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS00330
gene id: 573063:METIN_RS00330
uniprot id: D5VUC8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS05610
gene id: 573063:METIN_RS05610
uniprot id: D5VT75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

573063:METIN RS00985
gene id: 573063:METIN_RS00985
uniprot id: D5VQL8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

573063:METIN RS02145
gene id: 573063:METIN_RS02145
uniprot id: D5VR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

573063:METIN RS00120
gene id: 573063:METIN_RS00120
uniprot id: D5VU85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573063:METIN RS02000
gene id: 573063:METIN_RS02000
uniprot id: D5VR66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

573063:METIN RS00750
gene id: 573063:METIN_RS00750
uniprot id: D5VQH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

573063:METIN RS01620
gene id: 573063:METIN_RS01620
uniprot id: D5VQZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

573063:METIN RS03135
gene id: 573063:METIN_RS03135
uniprot id: D5VRU6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

573063:METIN RS01000
gene id: 573063:METIN_RS01000
uniprot id: D5VQM1
names: Similarity
messages: Belongs to the UPF0107 family.

573063:METIN RS03065
gene id: 573063:METIN_RS03065
uniprot id: D5VRT2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

573063:METIN RS05025
gene id: 573063:METIN_RS05025
uniprot id: D5VSW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

573063:METIN RS01075
gene id: 573063:METIN_RS01075
uniprot id: D5VQN6
names: Similarity
messages: Belongs to the ComB family.

573063:METIN RS04205
gene id: 573063:METIN_RS04205
uniprot id: D5VSF4
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

573063:METIN RS01405
gene id: 573063:METIN_RS01405
uniprot id: D5VQV0
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

573063:METIN RS03040
gene id: 573063:METIN_RS03040
uniprot id: D5VRS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

573063:METIN RS05995
gene id: 573063:METIN_RS05995
uniprot id: D5VTE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

573063:METIN RS01775
gene id: 573063:METIN_RS01775
uniprot id: D5VR22
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

573063:METIN RS04755
gene id: 573063:METIN_RS04755
uniprot id: D5VSQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

573063:METIN RS00310
gene id: 573063:METIN_RS00310
uniprot id: D5VUC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

573063:METIN RS05005
gene id: 573063:METIN_RS05005
uniprot id: D5VSV9
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

573063:METIN RS06785
gene id: 573063:METIN_RS06785
uniprot id: D5VTU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

573063:METIN RS02225
gene id: 573063:METIN_RS02225
uniprot id: D5VRB3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573063:METIN RS01970
gene id: 573063:METIN_RS01970
uniprot id: D5VR60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

573063:METIN RS03510
gene id: 573063:METIN_RS03510
uniprot id: D5VS20
names: Similarity
messages: Belongs to the MtxX family.

573063:METIN RS04955
gene id: 573063:METIN_RS04955
uniprot id: D5VSV2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

573063:METIN RS00970
gene id: 573063:METIN_RS00970
uniprot id: D5VQL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

573063:METIN RS00725
gene id: 573063:METIN_RS00725
uniprot id: D5VQG7
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS07645
gene id: 573063:METIN_RS07645
uniprot id: D5VS59
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

573063:METIN RS02925
gene id: 573063:METIN_RS02925
uniprot id: D5VRQ5
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

573063:METIN RS05020
gene id: 573063:METIN_RS05020
uniprot id: D5VSW2
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

573063:METIN RS02930
gene id: 573063:METIN_RS02930
uniprot id: D5VRQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS06335
gene id: 573063:METIN_RS06335
uniprot id: D5VTL8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

573063:METIN RS02800
gene id: 573063:METIN_RS02800
uniprot id: D5VRN1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS04360
gene id: 573063:METIN_RS04360
uniprot id: D5VSI5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

573063:METIN RS01385
gene id: 573063:METIN_RS01385
uniprot id: D5VQU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573063:METIN RS05420
gene id: 573063:METIN_RS05420
uniprot id: D5VT40
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

573063:METIN RS05220
gene id: 573063:METIN_RS05220
uniprot id: D5VT01
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

573063:METIN RS00515
gene id: 573063:METIN_RS00515
uniprot id: D5VQC5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

573063:METIN RS00355
gene id: 573063:METIN_RS00355
uniprot id: D5VUD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

573063:METIN RS00865
gene id: 573063:METIN_RS00865
uniprot id: D5VQJ4
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

573063:METIN RS02050
gene id: 573063:METIN_RS02050
uniprot id: D5VR77
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

573063:METIN RS00495
gene id: 573063:METIN_RS00495
uniprot id: D5VQC1
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS07695
gene id: 573063:METIN_RS07695
uniprot id: D5VU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

573063:METIN RS06825
gene id: 573063:METIN_RS06825
uniprot id: D5VTV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

573063:METIN RS00995
gene id: 573063:METIN_RS00995
uniprot id: D5VQM0
names: Similarity
messages: Belongs to the UPF0045 family.

573063:METIN RS02500
gene id: 573063:METIN_RS02500
uniprot id: D5VRG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573063:METIN RS06955
gene id: 573063:METIN_RS06955
uniprot id: D5VTX9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

573063:METIN RS04430
gene id: 573063:METIN_RS04430
uniprot id: D5VSJ9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

573063:METIN RS02475
gene id: 573063:METIN_RS02475
uniprot id: D5VRG4
names: Similarity
messages: Belongs to the HdrC family.

573063:METIN RS03020
gene id: 573063:METIN_RS03020
uniprot id: D5VRS4
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

573063:METIN RS01330
gene id: 573063:METIN_RS01330
uniprot id: D5VQT5
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

573063:METIN RS04320
gene id: 573063:METIN_RS04320
uniprot id: D5VSH7
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS02520
gene id: 573063:METIN_RS02520
uniprot id: D5VRH3
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

573063:METIN RS03140
gene id: 573063:METIN_RS03140
uniprot id: D5VRU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS06195
gene id: 573063:METIN_RS06195
uniprot id: D5VTJ0
names: Function
messages: Part of a potassium transport system.

573063:METIN RS07650
gene id: 573063:METIN_RS07650
uniprot id: D5VS60
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

573063:METIN RS05195
gene id: 573063:METIN_RS05195
uniprot id: D5VSZ6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

573063:METIN RS03265
gene id: 573063:METIN_RS03265
uniprot id: D5VRX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

573063:METIN RS02200
gene id: 573063:METIN_RS02200
uniprot id: D5VRA9
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS01460
gene id: 573063:METIN_RS01460
uniprot id: D5VQW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

573063:METIN RS01490
gene id: 573063:METIN_RS01490
uniprot id: D5VQW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

573063:METIN RS01835
gene id: 573063:METIN_RS01835
uniprot id: D5VR33
names: Similarity
messages: Belongs to the PDCD5 family.

573063:METIN RS00915
gene id: 573063:METIN_RS00915
uniprot id: D5VQK4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

573063:METIN RS03045
gene id: 573063:METIN_RS03045
uniprot id: D5VRS9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

573063:METIN RS02495
gene id: 573063:METIN_RS02495
uniprot id: D5VRG8
names: Function
messages: Probably involved in the biogenesis of the ribosome.

573063:METIN RS03095
gene id: 573063:METIN_RS03095
uniprot id: D5VRT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

573063:METIN RS05540
gene id: 573063:METIN_RS05540
uniprot id: D5VT61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

573063:METIN RS02530
gene id: 573063:METIN_RS02530
uniprot id: D5VRH5
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

573063:METIN RS03100
gene id: 573063:METIN_RS03100
uniprot id: D5VRT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

573063:METIN RS07360
gene id: 573063:METIN_RS07360
uniprot id: D5VU50
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS04510
gene id: 573063:METIN_RS04510
uniprot id: D5VSL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

573063:METIN RS05380
gene id: 573063:METIN_RS05380
uniprot id: D5VT32
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

573063:METIN RS03520
gene id: 573063:METIN_RS03520
uniprot id: D5VS22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS01665
gene id: 573063:METIN_RS01665
uniprot id: D5VR00
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

573063:METIN RS02685
gene id: 573063:METIN_RS02685
uniprot id: D5VRK6
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS01825
gene id: 573063:METIN_RS01825
uniprot id: D5VR31
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

573063:METIN RS04460
gene id: 573063:METIN_RS04460
uniprot id: D5VSK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

573063:METIN RS06280
gene id: 573063:METIN_RS06280
uniprot id: D5VTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

573063:METIN RS06665
gene id: 573063:METIN_RS06665
uniprot id: D5VTS2
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02965
gene id: 573063:METIN_RS02965
uniprot id: D5VRR3
names: Similarity
messages: Belongs to the archaeal ATPase family.

573063:METIN RS00235
gene id: 573063:METIN_RS00235
uniprot id: D5VUA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

573063:METIN RS05375
gene id: 573063:METIN_RS05375
uniprot id: D5VT31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

573063:METIN RS05135
gene id: 573063:METIN_RS05135
uniprot id: D5VSY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

573063:METIN RS07325
gene id: 573063:METIN_RS07325
uniprot id: D5VU44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

573063:METIN RS07155
gene id: 573063:METIN_RS07155
uniprot id: D5VU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573063:METIN RS03145
gene id: 573063:METIN_RS03145
uniprot id: D5VRU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

573063:METIN RS05190
gene id: 573063:METIN_RS05190
uniprot id: D5VSZ5
names: Similarity
messages: Belongs to the UPF0237 family.

573063:METIN RS01735
gene id: 573063:METIN_RS01735
uniprot id: D5VR14
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

573063:METIN RS05030
gene id: 573063:METIN_RS05030
uniprot id: D5VSW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

573063:METIN RS04020
gene id: 573063:METIN_RS04020
uniprot id: D5VSB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

573063:METIN RS06820
gene id: 573063:METIN_RS06820
uniprot id: D5VTV3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

573063:METIN RS04425
gene id: 573063:METIN_RS04425
uniprot id: D5VSJ8
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

573063:METIN RS03965
gene id: 573063:METIN_RS03965
uniprot id: D5VSA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

573063:METIN RS00950
gene id: 573063:METIN_RS00950
uniprot id: D5VQL1
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

573063:METIN RS00925
gene id: 573063:METIN_RS00925
uniprot id: D5VQK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573063:METIN RS05990
gene id: 573063:METIN_RS05990
uniprot id: D5VTE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

573063:METIN RS06425
gene id: 573063:METIN_RS06425
uniprot id: D5VTM5
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS02060
gene id: 573063:METIN_RS02060
uniprot id: D5VR79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

573063:METIN RS02290
gene id: 573063:METIN_RS02290
uniprot id: D5VRC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

573063:METIN RS04365
gene id: 573063:METIN_RS04365
uniprot id: D5VSI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

573063:METIN RS02250
gene id: 573063:METIN_RS02250
uniprot id: D5VRB8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

573063:METIN RS00010
gene id: 573063:METIN_RS00010
uniprot id: D5VU63
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

573063:METIN RS06875
gene id: 573063:METIN_RS06875
uniprot id: D5VTW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573063:METIN RS05750
gene id: 573063:METIN_RS05750
uniprot id: D5VTA3
names: Subcellular Location Annotation
messages: Membrane

573063:METIN RS06705
gene id: 573063:METIN_RS06705
uniprot id: D5VTT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

573063:METIN RS05175
gene id: 573063:METIN_RS05175
uniprot id: D5VSZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

573063:METIN RS03705
gene id: 573063:METIN_RS03705
uniprot id: D5VS57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

573063:METIN RS01660
gene id: 573063:METIN_RS01660
uniprot id: D5VQZ9
names: Similarity
messages: Belongs to the UPF0292 family.