572546:ARCPR RS02560
gene id: 572546:ARCPR_RS02560
uniprot id: D2RH01
names: Similarity
messages: Belongs to the SDO1/SBDS family.

572546:ARCPR RS04060
gene id: 572546:ARCPR_RS04060
uniprot id: D2RHV3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572546:ARCPR RS04870
gene id: 572546:ARCPR_RS04870
uniprot id: D2RIB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS05515
gene id: 572546:ARCPR_RS05515
uniprot id: D2RDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

572546:ARCPR RS06285
gene id: 572546:ARCPR_RS06285
uniprot id: D2RDW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

572546:ARCPR RS06715
gene id: 572546:ARCPR_RS06715
uniprot id: D2RE43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

572546:ARCPR RS06755
gene id: 572546:ARCPR_RS06755
uniprot id: D2RE51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS08535
gene id: 572546:ARCPR_RS08535
uniprot id: D2RF60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

572546:ARCPR RS04305
gene id: 572546:ARCPR_RS04305
uniprot id: D2RI05
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572546:ARCPR RS06750
gene id: 572546:ARCPR_RS06750
uniprot id: D2RE50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

572546:ARCPR RS00345
gene id: 572546:ARCPR_RS00345
uniprot id: D2RFS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572546:ARCPR RS03205
gene id: 572546:ARCPR_RS03205
uniprot id: D2RHD3
names: Similarity
messages: Belongs to the TlyA family.

572546:ARCPR RS03710
gene id: 572546:ARCPR_RS03710
uniprot id: D2RHN4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06745
gene id: 572546:ARCPR_RS06745
uniprot id: D2RE49
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

572546:ARCPR RS08290
gene id: 572546:ARCPR_RS08290
uniprot id: D2RF10
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS03010
gene id: 572546:ARCPR_RS03010
uniprot id: D2RH91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

572546:ARCPR RS05975
gene id: 572546:ARCPR_RS05975
uniprot id: D2RDQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

572546:ARCPR RS06085
gene id: 572546:ARCPR_RS06085
uniprot id: D2RDS3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

572546:ARCPR RS02885
gene id: 572546:ARCPR_RS02885
uniprot id: D2RH67
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

572546:ARCPR RS07295
gene id: 572546:ARCPR_RS07295
uniprot id: D2REF8
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS03035
gene id: 572546:ARCPR_RS03035
uniprot id: D2RH96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

572546:ARCPR RS02495
gene id: 572546:ARCPR_RS02495
uniprot id: D2RGY8
names: Similarity
messages: Belongs to the UPF0045 family.

572546:ARCPR RS03790
gene id: 572546:ARCPR_RS03790
uniprot id: D2RHQ0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

572546:ARCPR RS06585
gene id: 572546:ARCPR_RS06585
uniprot id: D2RE16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

572546:ARCPR RS06145
gene id: 572546:ARCPR_RS06145
uniprot id: D2RDT6
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

572546:ARCPR RS08185
gene id: 572546:ARCPR_RS08185
uniprot id: D2REY9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS02505
gene id: 572546:ARCPR_RS02505
uniprot id: D2RGZ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS02975
gene id: 572546:ARCPR_RS02975
uniprot id: D2RH84
names: Subunit
messages: Homotetramer.

572546:ARCPR RS01100
gene id: 572546:ARCPR_RS01100
uniprot id: D2RG67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

572546:ARCPR RS06880
gene id: 572546:ARCPR_RS06880
uniprot id: D2RE77
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

572546:ARCPR RS00945
gene id: 572546:ARCPR_RS00945
uniprot id: D2RG36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

572546:ARCPR RS08145
gene id: 572546:ARCPR_RS08145
uniprot id: D2REY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

572546:ARCPR RS03950
gene id: 572546:ARCPR_RS03950
uniprot id: D2RHT2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572546:ARCPR RS08270
gene id: 572546:ARCPR_RS08270
uniprot id: D2RF06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

572546:ARCPR RS05485
gene id: 572546:ARCPR_RS05485
uniprot id: D2RDF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

572546:ARCPR RS07115
gene id: 572546:ARCPR_RS07115
uniprot id: D2REC4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

572546:ARCPR RS00430
gene id: 572546:ARCPR_RS00430
uniprot id: D2RFU0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

572546:ARCPR RS06700
gene id: 572546:ARCPR_RS06700
uniprot id: D2RE39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

572546:ARCPR RS03400
gene id: 572546:ARCPR_RS03400
uniprot id: D2RHH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

572546:ARCPR RS01335
gene id: 572546:ARCPR_RS01335
uniprot id: D2RGB3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

572546:ARCPR RS02065
gene id: 572546:ARCPR_RS02065
uniprot id: D2RGQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

572546:ARCPR RS01060
gene id: 572546:ARCPR_RS01060
uniprot id: D2RG58
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS04010
gene id: 572546:ARCPR_RS04010
uniprot id: D2RHU3
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

572546:ARCPR RS08305
gene id: 572546:ARCPR_RS08305
uniprot id: D2RF13
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

572546:ARCPR RS02955
gene id: 572546:ARCPR_RS02955
uniprot id: D2RH80
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

572546:ARCPR RS06190
gene id: 572546:ARCPR_RS06190
uniprot id: D2RDU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

572546:ARCPR RS05025
gene id: 572546:ARCPR_RS05025
uniprot id: D2RD72
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

572546:ARCPR RS00235
gene id: 572546:ARCPR_RS00235
uniprot id: D2RFP9
names: Similarity
messages: Belongs to the DtxR/MntR family.

572546:ARCPR RS05335
gene id: 572546:ARCPR_RS05335
uniprot id: D2RDC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572546:ARCPR RS06685
gene id: 572546:ARCPR_RS06685
uniprot id: D2RE36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

572546:ARCPR RS07695
gene id: 572546:ARCPR_RS07695
uniprot id: D2REP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

572546:ARCPR RS06515
gene id: 572546:ARCPR_RS06515
uniprot id: D2RE05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

572546:ARCPR RS06825
gene id: 572546:ARCPR_RS06825
uniprot id: D2RE65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS06270
gene id: 572546:ARCPR_RS06270
uniprot id: D2RDV8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

572546:ARCPR RS07865
gene id: 572546:ARCPR_RS07865
uniprot id: D2RES5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

572546:ARCPR RS00315
gene id: 572546:ARCPR_RS00315
uniprot id: D2RFR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

572546:ARCPR RS05625
gene id: 572546:ARCPR_RS05625
uniprot id: D2RDI5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572546:ARCPR RS07320
gene id: 572546:ARCPR_RS07320
uniprot id: D2REG3
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS08195
gene id: 572546:ARCPR_RS08195
uniprot id: D2REZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

572546:ARCPR RS01740
gene id: 572546:ARCPR_RS01740
uniprot id: D2RGJ2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01730
gene id: 572546:ARCPR_RS01730
uniprot id: D2RGJ1
names: Similarity
messages: Belongs to the thymidylate kinase family.

572546:ARCPR RS00475
gene id: 572546:ARCPR_RS00475
uniprot id: D2RFU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

572546:ARCPR RS04345
gene id: 572546:ARCPR_RS04345
uniprot id: D2RI14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

572546:ARCPR RS01460
gene id: 572546:ARCPR_RS01460
uniprot id: D2RGD7
names: Similarity
messages: Belongs to the UPF0235 family.

572546:ARCPR RS07795
gene id: 572546:ARCPR_RS07795
uniprot id: D2RER2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572546:ARCPR RS05555
gene id: 572546:ARCPR_RS05555
uniprot id: D2RDH2
names: Similarity
messages: Belongs to the UPF0179 family.

572546:ARCPR RS09110
gene id: 572546:ARCPR_RS09110
uniprot id: D2RFH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

572546:ARCPR RS01595
gene id: 572546:ARCPR_RS01595
uniprot id: D2RGG5
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

572546:ARCPR RS03230
gene id: 572546:ARCPR_RS03230
uniprot id: D2RHD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

572546:ARCPR RS08645
gene id: 572546:ARCPR_RS08645
uniprot id: D2RF83
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

572546:ARCPR RS02405
gene id: 572546:ARCPR_RS02405
uniprot id: D2RGX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

572546:ARCPR RS00015
gene id: 572546:ARCPR_RS00015
uniprot id: D2RFK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

572546:ARCPR RS02575
gene id: 572546:ARCPR_RS02575
uniprot id: D2RH04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

572546:ARCPR RS06195
gene id: 572546:ARCPR_RS06195
uniprot id: D2RDU3
names: Similarity
messages: Belongs to the archaeal-type GPI family.

572546:ARCPR RS05570
gene id: 572546:ARCPR_RS05570
uniprot id: D2RDH5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

572546:ARCPR RS08685
gene id: 572546:ARCPR_RS08685
uniprot id: D2RF91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS07390
gene id: 572546:ARCPR_RS07390
uniprot id: D2REH7
names: Similarity
messages: Belongs to the MoaB/Mog family.

572546:ARCPR RS07970
gene id: 572546:ARCPR_RS07970
uniprot id: D2REU5
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.

572546:ARCPR RS01775
gene id: 572546:ARCPR_RS01775
uniprot id: D2RGJ9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS05005
gene id: 572546:ARCPR_RS05005
uniprot id: D2RD68
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS00065
gene id: 572546:ARCPR_RS00065
uniprot id: D2RFL7
names: Similarity
messages: Belongs to the Ahb/Nir family.

572546:ARCPR RS04790
gene id: 572546:ARCPR_RS04790
uniprot id: D2RI96
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS09420
gene id: 572546:ARCPR_RS09420
uniprot id: D2RF11
names: Similarity
messages: Belongs to the glutaredoxin family.

572546:ARCPR RS06800
gene id: 572546:ARCPR_RS06800
uniprot id: D2RE60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS06485
gene id: 572546:ARCPR_RS06485
uniprot id: D2RDZ9
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

572546:ARCPR RS01675
gene id: 572546:ARCPR_RS01675
uniprot id: D2RGI1
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Belongs to the UPF0201 family.

572546:ARCPR RS01360
gene id: 572546:ARCPR_RS01360
uniprot id: D2RGB8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

572546:ARCPR RS00100
gene id: 572546:ARCPR_RS00100
uniprot id: D2RFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

572546:ARCPR RS06535
gene id: 572546:ARCPR_RS06535
uniprot id: D2RE09
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

572546:ARCPR RS00865
gene id: 572546:ARCPR_RS00865
uniprot id: D2RG20
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01820
gene id: 572546:ARCPR_RS01820
uniprot id: D2RGK8
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

572546:ARCPR RS00145
gene id: 572546:ARCPR_RS00145
uniprot id: D2RFN2
names: Similarity
messages: Belongs to the intimin/invasin family.

572546:ARCPR RS04405
gene id: 572546:ARCPR_RS04405
uniprot id: D2RI24
names: Similarity
messages: Belongs to the UPF0282 family.

572546:ARCPR RS03255
gene id: 572546:ARCPR_RS03255
uniprot id: D2RHE3
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

572546:ARCPR RS07980
gene id: 572546:ARCPR_RS07980
uniprot id: D2REU7
names: Similarity
messages: Belongs to the UbiD family.

572546:ARCPR RS05910
gene id: 572546:ARCPR_RS05910
uniprot id: D2RDN8
names: Similarity
messages: Belongs to the UPF0175 family.

572546:ARCPR RS01915
gene id: 572546:ARCPR_RS01915
uniprot id: D2RGM5
names: Similarity
messages: Belongs to the glutamate synthase family.

572546:ARCPR RS03235
gene id: 572546:ARCPR_RS03235
uniprot id: D2RHD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572546:ARCPR RS03025
gene id: 572546:ARCPR_RS03025
uniprot id: D2RH94
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

572546:ARCPR RS00660
gene id: 572546:ARCPR_RS00660
uniprot id: D2RFY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS07705
gene id: 572546:ARCPR_RS07705
uniprot id: D2REP3
names: Similarity
messages: Belongs to the UPF0147 family.

572546:ARCPR RS00400
gene id: 572546:ARCPR_RS00400
uniprot id: D2RFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

572546:ARCPR RS08280
gene id: 572546:ARCPR_RS08280
uniprot id: D2RF08
names: Function
messages: Probably involved in the biogenesis of the ribosome.

572546:ARCPR RS03430
gene id: 572546:ARCPR_RS03430
uniprot id: D2RHH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS07810
gene id: 572546:ARCPR_RS07810
uniprot id: D2RER4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

572546:ARCPR RS07035
gene id: 572546:ARCPR_RS07035
uniprot id: D2REA8
names: Similarity
messages: Belongs to the AAA ATPase family.

572546:ARCPR RS01175
gene id: 572546:ARCPR_RS01175
uniprot id: D2RG82
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

572546:ARCPR RS01695
gene id: 572546:ARCPR_RS01695
uniprot id: D2RGI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

572546:ARCPR RS02105
gene id: 572546:ARCPR_RS02105
uniprot id: D2RGR1
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS05240
gene id: 572546:ARCPR_RS05240
uniprot id: D2RDB0
names: Similarity
messages: Belongs to the MEMO1 family.

572546:ARCPR RS07085
gene id: 572546:ARCPR_RS07085
uniprot id: D2REB8
names: Similarity
messages: Belongs to the ZPR1 family.

572546:ARCPR RS07825
gene id: 572546:ARCPR_RS07825
uniprot id: D2RER7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

572546:ARCPR RS03030
gene id: 572546:ARCPR_RS03030
uniprot id: D2RH95
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS06300
gene id: 572546:ARCPR_RS06300
uniprot id: D2RDW4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

572546:ARCPR RS04625
gene id: 572546:ARCPR_RS04625
uniprot id: D2RI64
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572546:ARCPR RS05385
gene id: 572546:ARCPR_RS05385
uniprot id: D2RDD9
names: Similarity
messages: Belongs to the BtpA family.

572546:ARCPR RS03180
gene id: 572546:ARCPR_RS03180
uniprot id: D2RHC7
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

572546:ARCPR RS01540
gene id: 572546:ARCPR_RS01540
uniprot id: D2RGF3
names: Similarity
messages: Belongs to the UPF0284 family.

572546:ARCPR RS01905
gene id: 572546:ARCPR_RS01905
uniprot id: D2RGM3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

572546:ARCPR RS06380
gene id: 572546:ARCPR_RS06380
uniprot id: D2RDY0
names: Similarity
messages: Belongs to the UPF0111 family.

572546:ARCPR RS09040
gene id: 572546:ARCPR_RS09040
uniprot id: D2RFG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06600
gene id: 572546:ARCPR_RS06600
uniprot id: D2RE19
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS08230
gene id: 572546:ARCPR_RS08230
uniprot id: D2REZ8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

572546:ARCPR RS03860
gene id: 572546:ARCPR_RS03860
uniprot id: D2RHR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

572546:ARCPR RS00290
gene id: 572546:ARCPR_RS00290
uniprot id: D2RFR0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

572546:ARCPR RS01030
gene id: 572546:ARCPR_RS01030
uniprot id: D2RG52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

572546:ARCPR RS02735
gene id: 572546:ARCPR_RS02735
uniprot id: D2RH37
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

572546:ARCPR RS05610
gene id: 572546:ARCPR_RS05610
uniprot id: D2RDI2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

572546:ARCPR RS00790
gene id: 572546:ARCPR_RS00790
uniprot id: D2RG05
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS01395
gene id: 572546:ARCPR_RS01395
uniprot id: D2RGC4
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00220
gene id: 572546:ARCPR_RS00220
uniprot id: D2RFP7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

572546:ARCPR RS04350
gene id: 572546:ARCPR_RS04350
uniprot id: D2RI15
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS08435
gene id: 572546:ARCPR_RS08435
uniprot id: D2RF41
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

572546:ARCPR RS00195
gene id: 572546:ARCPR_RS00195
uniprot id: D2RFP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

572546:ARCPR RS02165
gene id: 572546:ARCPR_RS02165
uniprot id: D2RGS4
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

572546:ARCPR RS03450
gene id: 572546:ARCPR_RS03450
uniprot id: D2RHI0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572546:ARCPR RS03480
gene id: 572546:ARCPR_RS03480
uniprot id: D2RHI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

572546:ARCPR RS06255
gene id: 572546:ARCPR_RS06255
uniprot id: D2RDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

572546:ARCPR RS04890
gene id: 572546:ARCPR_RS04890
uniprot id: D2RIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

572546:ARCPR RS06340
gene id: 572546:ARCPR_RS06340
uniprot id: D2RDX2
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

572546:ARCPR RS06775
gene id: 572546:ARCPR_RS06775
uniprot id: D2RE55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS07840
gene id: 572546:ARCPR_RS07840
uniprot id: D2RES0
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00295
gene id: 572546:ARCPR_RS00295
uniprot id: D2RFR1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

572546:ARCPR RS02000
gene id: 572546:ARCPR_RS02000
uniprot id: D2RGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

572546:ARCPR RS06400
gene id: 572546:ARCPR_RS06400
uniprot id: D2RDY4
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

572546:ARCPR RS05890
gene id: 572546:ARCPR_RS05890
uniprot id: D2RDN4
names: Similarity
messages: Belongs to the UPF0175 family.

572546:ARCPR RS08670
gene id: 572546:ARCPR_RS08670
uniprot id: D2RF88
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

572546:ARCPR RS07305
gene id: 572546:ARCPR_RS07305
uniprot id: D2REG0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

572546:ARCPR RS04070
gene id: 572546:ARCPR_RS04070
uniprot id: D2RHV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

572546:ARCPR RS04955
gene id: 572546:ARCPR_RS04955
uniprot id: D2RD59
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

572546:ARCPR RS02965
gene id: 572546:ARCPR_RS02965
uniprot id: D2RH82
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

572546:ARCPR RS07350
gene id: 572546:ARCPR_RS07350
uniprot id: D2REH0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

572546:ARCPR RS06780
gene id: 572546:ARCPR_RS06780
uniprot id: D2RE56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

572546:ARCPR RS03820
gene id: 572546:ARCPR_RS03820
uniprot id: D2RHQ6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

572546:ARCPR RS00855
gene id: 572546:ARCPR_RS00855
uniprot id: D2RG18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

572546:ARCPR RS05275
gene id: 572546:ARCPR_RS05275
uniprot id: D2RDB7
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

572546:ARCPR RS03690
gene id: 572546:ARCPR_RS03690
uniprot id: D2RHN0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572546:ARCPR RS01700
gene id: 572546:ARCPR_RS01700
uniprot id: D2RGI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

572546:ARCPR RS01565
gene id: 572546:ARCPR_RS01565
uniprot id: D2RGF8
names: Caution
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS03140
gene id: 572546:ARCPR_RS03140
uniprot id: D2RHB9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

572546:ARCPR RS09075
gene id: 572546:ARCPR_RS09075
uniprot id: D2RFG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS02490
gene id: 572546:ARCPR_RS02490
uniprot id: D2RGY7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

572546:ARCPR RS01445
gene id: 572546:ARCPR_RS01445
uniprot id: D2RGD4
names: Similarity
messages: Belongs to the UPF0280 family.

572546:ARCPR RS03560
gene id: 572546:ARCPR_RS03560
uniprot id: D2RHK2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

572546:ARCPR RS00150
gene id: 572546:ARCPR_RS00150
uniprot id: D2RFN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

572546:ARCPR RS05580
gene id: 572546:ARCPR_RS05580
uniprot id: D2RDH7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

572546:ARCPR RS09115
gene id: 572546:ARCPR_RS09115
uniprot id: D2RFH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

572546:ARCPR RS04995
gene id: 572546:ARCPR_RS04995
uniprot id: D2RD66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01145
gene id: 572546:ARCPR_RS01145
uniprot id: D2RG76
names: Similarity
messages: Belongs to the band 7/mec-2 family.

572546:ARCPR RS02220
gene id: 572546:ARCPR_RS02220
uniprot id: D2RGT5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

572546:ARCPR RS05140
gene id: 572546:ARCPR_RS05140
uniprot id: D2RD91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

572546:ARCPR RS03620
gene id: 572546:ARCPR_RS03620
uniprot id: D2RHL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS07855
gene id: 572546:ARCPR_RS07855
uniprot id: D2RES3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00265
gene id: 572546:ARCPR_RS00265
uniprot id: D2RFQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

572546:ARCPR RS06530
gene id: 572546:ARCPR_RS06530
uniprot id: D2RE08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572546:ARCPR RS02570
gene id: 572546:ARCPR_RS02570
uniprot id: D2RH03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

572546:ARCPR RS03390
gene id: 572546:ARCPR_RS03390
uniprot id: D2RHG8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00480
gene id: 572546:ARCPR_RS00480
uniprot id: D2RFU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS01015
gene id: 572546:ARCPR_RS01015
uniprot id: D2RG49
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS02180
gene id: 572546:ARCPR_RS02180
uniprot id: D2RGS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

572546:ARCPR RS06140
gene id: 572546:ARCPR_RS06140
uniprot id: D2RDT5
names: Similarity
messages: Belongs to the HypE family.

572546:ARCPR RS06375
gene id: 572546:ARCPR_RS06375
uniprot id: D2RDX9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

572546:ARCPR RS03655
gene id: 572546:ARCPR_RS03655
uniprot id: D2RHM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS07030
gene id: 572546:ARCPR_RS07030
uniprot id: D2REA7
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.

572546:ARCPR RS06135
gene id: 572546:ARCPR_RS06135
uniprot id: D2RDT4
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

572546:ARCPR RS10055
gene id: 572546:ARCPR_RS10055
uniprot id: D2RFX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS00940
gene id: 572546:ARCPR_RS00940
uniprot id: D2RG35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

572546:ARCPR RS04845
gene id: 572546:ARCPR_RS04845
uniprot id: D2RIA9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

572546:ARCPR RS03810
gene id: 572546:ARCPR_RS03810
uniprot id: D2RHQ4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

572546:ARCPR RS03840
gene id: 572546:ARCPR_RS03840
uniprot id: D2RHR0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS09025
gene id: 572546:ARCPR_RS09025
uniprot id: D2RFF8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

572546:ARCPR RS06690
gene id: 572546:ARCPR_RS06690
uniprot id: D2RE37
names: Similarity
messages: Belongs to the AOR/FOR family.

572546:ARCPR RS00645
gene id: 572546:ARCPR_RS00645
uniprot id: D2RFX8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

572546:ARCPR RS05395
gene id: 572546:ARCPR_RS05395
uniprot id: D2RDE1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS02670
gene id: 572546:ARCPR_RS02670
uniprot id: D2RH23
names: Similarity
messages: Belongs to the class-I fumarase family.

572546:ARCPR RS03915
gene id: 572546:ARCPR_RS03915
uniprot id: D2RHS5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

572546:ARCPR RS01685
gene id: 572546:ARCPR_RS01685
uniprot id: D2RGI2
names: Subunit
messages: Homodimer.

572546:ARCPR RS00175
gene id: 572546:ARCPR_RS00175
uniprot id: D2RFN8
names: Similarity
messages: Belongs to the UPF0173 family.

572546:ARCPR RS01165
gene id: 572546:ARCPR_RS01165
uniprot id: D2RG80
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

572546:ARCPR RS07805
gene id: 572546:ARCPR_RS07805
uniprot id: D2RER3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

572546:ARCPR RS00715
gene id: 572546:ARCPR_RS00715
uniprot id: D2RFZ1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

572546:ARCPR RS06075
gene id: 572546:ARCPR_RS06075
uniprot id: D2RDS1
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS01810
gene id: 572546:ARCPR_RS01810
uniprot id: D2RGK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

572546:ARCPR RS04640
gene id: 572546:ARCPR_RS04640
uniprot id: D2RI67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

572546:ARCPR RS01720
gene id: 572546:ARCPR_RS01720
uniprot id: D2RGI9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01135
gene id: 572546:ARCPR_RS01135
uniprot id: D2RG74
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

572546:ARCPR RS02215
gene id: 572546:ARCPR_RS02215
uniprot id: D2RGT4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

572546:ARCPR RS06350
gene id: 572546:ARCPR_RS06350
uniprot id: D2RDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

572546:ARCPR RS02770
gene id: 572546:ARCPR_RS02770
uniprot id: D2RH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS04875
gene id: 572546:ARCPR_RS04875
uniprot id: D2RIB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS05190
gene id: 572546:ARCPR_RS05190
uniprot id: D2RDA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

572546:ARCPR RS02860
gene id: 572546:ARCPR_RS02860
uniprot id: D2RH62
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

572546:ARCPR RS06660
gene id: 572546:ARCPR_RS06660
uniprot id: D2RE31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS06205
gene id: 572546:ARCPR_RS06205
uniprot id: D2RDU5
names: Similarity
messages: Belongs to the UPF0111 family.

572546:ARCPR RS00830
gene id: 572546:ARCPR_RS00830
uniprot id: D2RG13
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS06495
gene id: 572546:ARCPR_RS06495
uniprot id: D2RE01
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

572546:ARCPR RS05030
gene id: 572546:ARCPR_RS05030
uniprot id: D2RD73
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

572546:ARCPR RS04605
gene id: 572546:ARCPR_RS04605
uniprot id: D2RI61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572546:ARCPR RS05640
gene id: 572546:ARCPR_RS05640
uniprot id: D2RDI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

572546:ARCPR RS07265
gene id: 572546:ARCPR_RS07265
uniprot id: D2REF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

572546:ARCPR RS05320
gene id: 572546:ARCPR_RS05320
uniprot id: D2RDC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

572546:ARCPR RS02440
gene id: 572546:ARCPR_RS02440
uniprot id: D2RGX7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01965
gene id: 572546:ARCPR_RS01965
uniprot id: D2RGN5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

572546:ARCPR RS03700
gene id: 572546:ARCPR_RS03700
uniprot id: D2RHN2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

572546:ARCPR RS00740
gene id: 572546:ARCPR_RS00740
uniprot id: D2RFZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

572546:ARCPR RS05105
gene id: 572546:ARCPR_RS05105
uniprot id: D2RD85
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

572546:ARCPR RS08590
gene id: 572546:ARCPR_RS08590
uniprot id: D2RF71
names: Subcellular Location Annotation
messages: Cell membrane

572546:ARCPR RS07105
gene id: 572546:ARCPR_RS07105
uniprot id: D2REC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

572546:ARCPR RS04985
gene id: 572546:ARCPR_RS04985
uniprot id: D2RD64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

572546:ARCPR RS02970
gene id: 572546:ARCPR_RS02970
uniprot id: D2RH83
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572546:ARCPR RS01755
gene id: 572546:ARCPR_RS01755
uniprot id: D2RGJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572546:ARCPR RS05545
gene id: 572546:ARCPR_RS05545
uniprot id: D2RDH0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

572546:ARCPR RS02350
gene id: 572546:ARCPR_RS02350
uniprot id: D2RGV8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

572546:ARCPR RS00285
gene id: 572546:ARCPR_RS00285
uniprot id: D2RFQ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01315
gene id: 572546:ARCPR_RS01315
uniprot id: D2RGB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00730
gene id: 572546:ARCPR_RS00730
uniprot id: D2RFZ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01180
gene id: 572546:ARCPR_RS01180
uniprot id: D2RG83
names: Similarity
messages: Belongs to the PDCD5 family.

572546:ARCPR RS00900
gene id: 572546:ARCPR_RS00900
uniprot id: D2RG27
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

572546:ARCPR RS01605
gene id: 572546:ARCPR_RS01605
uniprot id: D2RGG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

572546:ARCPR RS00215
gene id: 572546:ARCPR_RS00215
uniprot id: D2RFP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

572546:ARCPR RS07760
gene id: 572546:ARCPR_RS07760
uniprot id: P84623
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrB family.
messages: Cytoplasm
messages: Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.
messages: The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

572546:ARCPR RS04585
gene id: 572546:ARCPR_RS04585
uniprot id: D2RI57
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

572546:ARCPR RS00470
gene id: 572546:ARCPR_RS00470
uniprot id: D2RFU4
names: Similarity
messages: Belongs to the PstS family.

572546:ARCPR RS02660
gene id: 572546:ARCPR_RS02660
uniprot id: D2RH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS05205
gene id: 572546:ARCPR_RS05205
uniprot id: D2RDA4
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS03305
gene id: 572546:ARCPR_RS03305
uniprot id: D2RHF3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class II subfamily.
messages: Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

572546:ARCPR RS09050
gene id: 572546:ARCPR_RS09050
uniprot id: D2RFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572546:ARCPR RS07380
gene id: 572546:ARCPR_RS07380
uniprot id: D2REH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

572546:ARCPR RS03440
gene id: 572546:ARCPR_RS03440
uniprot id: D2RHH8
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS07725
gene id: 572546:ARCPR_RS07725
uniprot id: D2REP8
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

572546:ARCPR RS05125
gene id: 572546:ARCPR_RS05125
uniprot id: D2RD88
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

572546:ARCPR RS05605
gene id: 572546:ARCPR_RS05605
uniprot id: D2RDI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

572546:ARCPR RS04650
gene id: 572546:ARCPR_RS04650
uniprot id: D2RI69
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

572546:ARCPR RS06200
gene id: 572546:ARCPR_RS06200
uniprot id: D2RDU4
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS07850
gene id: 572546:ARCPR_RS07850
uniprot id: D2RES2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

572546:ARCPR RS02800
gene id: 572546:ARCPR_RS02800
uniprot id: D2RH49
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

572546:ARCPR RS02045
gene id: 572546:ARCPR_RS02045
uniprot id: D2RGP9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

572546:ARCPR RS00535
gene id: 572546:ARCPR_RS00535
uniprot id: D2RFV7
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572546:ARCPR RS07385
gene id: 572546:ARCPR_RS07385
uniprot id: D2REH6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

572546:ARCPR RS01070
gene id: 572546:ARCPR_RS01070
uniprot id: D2RG60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

572546:ARCPR RS05110
gene id: 572546:ARCPR_RS05110
uniprot id: D2RD86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

572546:ARCPR RS03260
gene id: 572546:ARCPR_RS03260
uniprot id: D2RHE4
names: Similarity
messages: Belongs to the HerA family.

572546:ARCPR RS08210
gene id: 572546:ARCPR_RS08210
uniprot id: D2REZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

572546:ARCPR RS08675
gene id: 572546:ARCPR_RS08675
uniprot id: D2RF89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

572546:ARCPR RS07990
gene id: 572546:ARCPR_RS07990
uniprot id: D2REU9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

572546:ARCPR RS06115
gene id: 572546:ARCPR_RS06115
uniprot id: D2RDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

572546:ARCPR RS03595
gene id: 572546:ARCPR_RS03595
uniprot id: D2RHK9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS04880
gene id: 572546:ARCPR_RS04880
uniprot id: D2RIB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS01850
gene id: 572546:ARCPR_RS01850
uniprot id: D2RGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

572546:ARCPR RS08630
gene id: 572546:ARCPR_RS08630
uniprot id: P84628
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Has menaquinol-oxidizing activity. The HmeC and HmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane.

572546:ARCPR RS06630
gene id: 572546:ARCPR_RS06630
uniprot id: D2RE25
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS06580
gene id: 572546:ARCPR_RS06580
uniprot id: D2RE15
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

572546:ARCPR RS05145
gene id: 572546:ARCPR_RS05145
uniprot id: D2RD92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

572546:ARCPR RS02525
gene id: 572546:ARCPR_RS02525
uniprot id: D2RGZ4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

572546:ARCPR RS00795
gene id: 572546:ARCPR_RS00795
uniprot id: D2RG06
names: Similarity
messages: Belongs to the FTR family.

572546:ARCPR RS05285
gene id: 572546:ARCPR_RS05285
uniprot id: D2RDB9
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

572546:ARCPR RS03625
gene id: 572546:ARCPR_RS03625
uniprot id: D2RHL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

572546:ARCPR RS06040
gene id: 572546:ARCPR_RS06040
uniprot id: D2RDR4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

572546:ARCPR RS06805
gene id: 572546:ARCPR_RS06805
uniprot id: D2RE61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

572546:ARCPR RS06225
gene id: 572546:ARCPR_RS06225
uniprot id: D2RDU9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06740
gene id: 572546:ARCPR_RS06740
uniprot id: D2RE48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS05115
gene id: 572546:ARCPR_RS05115
uniprot id: D2RD87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

572546:ARCPR RS00650
gene id: 572546:ARCPR_RS00650
uniprot id: D2RFX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

572546:ARCPR RS07150
gene id: 572546:ARCPR_RS07150
uniprot id: D2RED1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

572546:ARCPR RS03850
gene id: 572546:ARCPR_RS03850
uniprot id: D2RHR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

572546:ARCPR RS01555
gene id: 572546:ARCPR_RS01555
uniprot id: D2RGF6
names: Similarity
messages: Belongs to the HupF/HypC family.

572546:ARCPR RS04965
gene id: 572546:ARCPR_RS04965
uniprot id: D2RD61
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

572546:ARCPR RS07935
gene id: 572546:ARCPR_RS07935
uniprot id: D2RET8
names: Similarity
messages: Belongs to the MTD family.

572546:ARCPR RS06230
gene id: 572546:ARCPR_RS06230
uniprot id: D2RDV0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

572546:ARCPR RS02535
gene id: 572546:ARCPR_RS02535
uniprot id: D2RGZ6
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

572546:ARCPR RS08610
gene id: 572546:ARCPR_RS08610
uniprot id: D2RF76
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

572546:ARCPR RS05520
gene id: 572546:ARCPR_RS05520
uniprot id: D2RDG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

572546:ARCPR RS04850
gene id: 572546:ARCPR_RS04850
uniprot id: D2RIB0
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

572546:ARCPR RS00160
gene id: 572546:ARCPR_RS00160
uniprot id: D2RFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

572546:ARCPR RS07730
gene id: 572546:ARCPR_RS07730
uniprot id: D2REP9
names: Similarity
messages: Belongs to the phosphoribulokinase family.

572546:ARCPR RS03185
gene id: 572546:ARCPR_RS03185
uniprot id: D2RHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

572546:ARCPR RS08560
gene id: 572546:ARCPR_RS08560
uniprot id: D2RF65
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

572546:ARCPR RS02485
gene id: 572546:ARCPR_RS02485
uniprot id: D2RGY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

572546:ARCPR RS02050
gene id: 572546:ARCPR_RS02050
uniprot id: D2RGQ0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

572546:ARCPR RS00340
gene id: 572546:ARCPR_RS00340
uniprot id: D2RFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572546:ARCPR RS07885
gene id: 572546:ARCPR_RS07885
uniprot id: D2RES9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS00465
gene id: 572546:ARCPR_RS00465
uniprot id: D2RFU3
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

572546:ARCPR RS02645
gene id: 572546:ARCPR_RS02645
uniprot id: D2RH18
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

572546:ARCPR RS08625
gene id: 572546:ARCPR_RS08625
uniprot id: D2RF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

572546:ARCPR RS02985
gene id: 572546:ARCPR_RS02985
uniprot id: D2RH86
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

572546:ARCPR RS09220
gene id: 572546:ARCPR_RS09220
uniprot id: D2RFJ8
names: Similarity
messages: Belongs to the malic enzymes family.

572546:ARCPR RS00110
gene id: 572546:ARCPR_RS00110
uniprot id: D2RFM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

572546:ARCPR RS01055
gene id: 572546:ARCPR_RS01055
uniprot id: D2RG57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

572546:ARCPR RS06710
gene id: 572546:ARCPR_RS06710
uniprot id: D2RE42
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS05865
gene id: 572546:ARCPR_RS05865
uniprot id: D2RDN0
names: Similarity
messages: Belongs to the UPF0175 family.

572546:ARCPR RS08240
gene id: 572546:ARCPR_RS08240
uniprot id: D2RF00
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572546:ARCPR RS05880
gene id: 572546:ARCPR_RS05880
uniprot id: D2RDN2
names: Similarity
messages: Belongs to the UPF0175 family.

572546:ARCPR RS09640
gene id: 572546:ARCPR_RS09640
uniprot id: D2RE62
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

572546:ARCPR RS06475
gene id: 572546:ARCPR_RS06475
uniprot id: D2RDZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

572546:ARCPR RS06185
gene id: 572546:ARCPR_RS06185
uniprot id: D2RDU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

572546:ARCPR RS03805
gene id: 572546:ARCPR_RS03805
uniprot id: D2RHQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

572546:ARCPR RS01960
gene id: 572546:ARCPR_RS01960
uniprot id: D2RGN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

572546:ARCPR RS07130
gene id: 572546:ARCPR_RS07130
uniprot id: D2REC7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01045
gene id: 572546:ARCPR_RS01045
uniprot id: D2RG55
names: Similarity
messages: Belongs to the TrpF family.

572546:ARCPR RS05540
gene id: 572546:ARCPR_RS05540
uniprot id: D2RDG9
names: Similarity
messages: Belongs to the GARS family.

572546:ARCPR RS07995
gene id: 572546:ARCPR_RS07995
uniprot id: D2REV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

572546:ARCPR RS01485
gene id: 572546:ARCPR_RS01485
uniprot id: D2RGE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572546:ARCPR RS04635
gene id: 572546:ARCPR_RS04635
uniprot id: D2RI66
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

572546:ARCPR RS06100
gene id: 572546:ARCPR_RS06100
uniprot id: D2RDS6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

572546:ARCPR RS06480
gene id: 572546:ARCPR_RS06480
uniprot id: D2RDZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

572546:ARCPR RS07095
gene id: 572546:ARCPR_RS07095
uniprot id: D2REC0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00165
gene id: 572546:ARCPR_RS00165
uniprot id: D2RFN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

572546:ARCPR RS03970
gene id: 572546:ARCPR_RS03970
uniprot id: D2RHT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

572546:ARCPR RS00800
gene id: 572546:ARCPR_RS00800
uniprot id: D2RG07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

572546:ARCPR RS07745
gene id: 572546:ARCPR_RS07745
uniprot id: P84625
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cytoplasm
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr).

572546:ARCPR RS02465
gene id: 572546:ARCPR_RS02465
uniprot id: D2RGY2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS04925
gene id: 572546:ARCPR_RS04925
uniprot id: D2RIC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

572546:ARCPR RS06210
gene id: 572546:ARCPR_RS06210
uniprot id: D2RDU6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

572546:ARCPR RS08635
gene id: 572546:ARCPR_RS08635
uniprot id: P84622
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Has menaquinol-oxidizing activity. The HmeC and HmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane.
messages: Membrane

572546:ARCPR RS02500
gene id: 572546:ARCPR_RS02500
uniprot id: D2RGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

572546:ARCPR RS07200
gene id: 572546:ARCPR_RS07200
uniprot id: D2REE0
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

572546:ARCPR RS05265
gene id: 572546:ARCPR_RS05265
uniprot id: D2RDB5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

572546:ARCPR RS05900
gene id: 572546:ARCPR_RS05900
uniprot id: D2RDN6
names: Similarity
messages: Belongs to the UPF0175 family.

572546:ARCPR RS06705
gene id: 572546:ARCPR_RS06705
uniprot id: D2RE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

572546:ARCPR RS09155
gene id: 572546:ARCPR_RS09155
uniprot id: D2RFI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

572546:ARCPR RS01365
gene id: 572546:ARCPR_RS01365
uniprot id: D2RGB9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

572546:ARCPR RS02935
gene id: 572546:ARCPR_RS02935
uniprot id: D2RH76
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

572546:ARCPR RS00375
gene id: 572546:ARCPR_RS00375
uniprot id: D2RFS8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

572546:ARCPR RS03245
gene id: 572546:ARCPR_RS03245
uniprot id: D2RHE1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

572546:ARCPR RS03300
gene id: 572546:ARCPR_RS03300
uniprot id: D2RHF2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

572546:ARCPR RS02550
gene id: 572546:ARCPR_RS02550
uniprot id: D2RGZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

572546:ARCPR RS00775
gene id: 572546:ARCPR_RS00775
uniprot id: D2RG02
names: Similarity
messages: Belongs to the DtxR/MntR family.

572546:ARCPR RS00030
gene id: 572546:ARCPR_RS00030
uniprot id: D2RFK9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

572546:ARCPR RS06975
gene id: 572546:ARCPR_RS06975
uniprot id: D2RE96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

572546:ARCPR RS01160
gene id: 572546:ARCPR_RS01160
uniprot id: D2RG79
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

572546:ARCPR RS02895
gene id: 572546:ARCPR_RS02895
uniprot id: D2RH68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

572546:ARCPR RS05055
gene id: 572546:ARCPR_RS05055
uniprot id: D2RD78
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

572546:ARCPR RS02130
gene id: 572546:ARCPR_RS02130
uniprot id: D2RGR7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

572546:ARCPR RS01550
gene id: 572546:ARCPR_RS01550
uniprot id: D2RGF5
names: Similarity
messages: Belongs to the HypD family.

572546:ARCPR RS07140
gene id: 572546:ARCPR_RS07140
uniprot id: D2REC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

572546:ARCPR RS04825
gene id: 572546:ARCPR_RS04825
uniprot id: D2RIA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

572546:ARCPR RS08660
gene id: 572546:ARCPR_RS08660
uniprot id: D2RF86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

572546:ARCPR RS03295
gene id: 572546:ARCPR_RS03295
uniprot id: D2RHF1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

572546:ARCPR RS00255
gene id: 572546:ARCPR_RS00255
uniprot id: D2RFQ3
names: Similarity
messages: Belongs to the UPF0047 family.

572546:ARCPR RS07685
gene id: 572546:ARCPR_RS07685
uniprot id: D2REN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

572546:ARCPR RS03995
gene id: 572546:ARCPR_RS03995
uniprot id: D2RHU0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

572546:ARCPR RS09085
gene id: 572546:ARCPR_RS09085
uniprot id: D2RFH0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

572546:ARCPR RS08220
gene id: 572546:ARCPR_RS08220
uniprot id: D2REZ6
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572546:ARCPR RS01835
gene id: 572546:ARCPR_RS01835
uniprot id: D2RGL1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

572546:ARCPR RS03485
gene id: 572546:ARCPR_RS03485
uniprot id: D2RHI7
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

572546:ARCPR RS01585
gene id: 572546:ARCPR_RS01585
uniprot id: D2RGG3
names: Similarity
messages: Belongs to the UPF0216 family.

572546:ARCPR RS05035
gene id: 572546:ARCPR_RS05035
uniprot id: D2RD74
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06395
gene id: 572546:ARCPR_RS06395
uniprot id: D2RDY3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06665
gene id: 572546:ARCPR_RS06665
uniprot id: D2RE32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

572546:ARCPR RS00205
gene id: 572546:ARCPR_RS00205
uniprot id: D2RFP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

572546:ARCPR RS02630
gene id: 572546:ARCPR_RS02630
uniprot id: D2RH15
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS03535
gene id: 572546:ARCPR_RS03535
uniprot id: D2RHJ7
names: Similarity
messages: Belongs to the aspartokinase family.

572546:ARCPR RS00425
gene id: 572546:ARCPR_RS00425
uniprot id: D2RFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS07670
gene id: 572546:ARCPR_RS07670
uniprot id: D2REN6
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS02385
gene id: 572546:ARCPR_RS02385
uniprot id: D2RGW6
names: Similarity
messages: Belongs to the DMRL synthase family.

572546:ARCPR RS03515
gene id: 572546:ARCPR_RS03515
uniprot id: D2RHJ3
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00735
gene id: 572546:ARCPR_RS00735
uniprot id: D2RFZ5
names: Function
messages: Part of a potassium transport system.

572546:ARCPR RS02650
gene id: 572546:ARCPR_RS02650
uniprot id: D2RH19
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572546:ARCPR RS03005
gene id: 572546:ARCPR_RS03005
uniprot id: D2RH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

572546:ARCPR RS00675
gene id: 572546:ARCPR_RS00675
uniprot id: D2RFY3
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

572546:ARCPR RS04795
gene id: 572546:ARCPR_RS04795
uniprot id: D2RI97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

572546:ARCPR RS01415
gene id: 572546:ARCPR_RS01415
uniprot id: D2RGC8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

572546:ARCPR RS06830
gene id: 572546:ARCPR_RS06830
uniprot id: D2RE66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

572546:ARCPR RS06655
gene id: 572546:ARCPR_RS06655
uniprot id: D2RE30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

572546:ARCPR RS05835
gene id: 572546:ARCPR_RS05835
uniprot id: D2RDM5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

572546:ARCPR RS01330
gene id: 572546:ARCPR_RS01330
uniprot id: D2RGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

572546:ARCPR RS03755
gene id: 572546:ARCPR_RS03755
uniprot id: D2RHP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

572546:ARCPR RS01790
gene id: 572546:ARCPR_RS01790
uniprot id: D2RGK2
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

572546:ARCPR RS01410
gene id: 572546:ARCPR_RS01410
uniprot id: D2RGC7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS04905
gene id: 572546:ARCPR_RS04905
uniprot id: D2RIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

572546:ARCPR RS09245
gene id: 572546:ARCPR_RS09245
uniprot id: D2RFK3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

572546:ARCPR RS02175
gene id: 572546:ARCPR_RS02175
uniprot id: D2RGS6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06345
gene id: 572546:ARCPR_RS06345
uniprot id: D2RDX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

572546:ARCPR RS07080
gene id: 572546:ARCPR_RS07080
uniprot id: D2REB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

572546:ARCPR RS08200
gene id: 572546:ARCPR_RS08200
uniprot id: D2REZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

572546:ARCPR RS01940
gene id: 572546:ARCPR_RS01940
uniprot id: D2RGN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

572546:ARCPR RS05600
gene id: 572546:ARCPR_RS05600
uniprot id: D2RDI0
names: Similarity
messages: Belongs to the UPF0292 family.

572546:ARCPR RS04370
gene id: 572546:ARCPR_RS04370
uniprot id: D2RI19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

572546:ARCPR RS06445
gene id: 572546:ARCPR_RS06445
uniprot id: D2RDZ1
names: Similarity
messages: Belongs to the glutaredoxin family.

572546:ARCPR RS08615
gene id: 572546:ARCPR_RS08615
uniprot id: D2RF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

572546:ARCPR RS06895
gene id: 572546:ARCPR_RS06895
uniprot id: D2RE80
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

572546:ARCPR RS04615
gene id: 572546:ARCPR_RS04615
uniprot id: D2RI63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

572546:ARCPR RS05295
gene id: 572546:ARCPR_RS05295
uniprot id: D2RDC1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

572546:ARCPR RS05045
gene id: 572546:ARCPR_RS05045
uniprot id: D2RD76
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

572546:ARCPR RS04805
gene id: 572546:ARCPR_RS04805
uniprot id: D2RI99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

572546:ARCPR RS04055
gene id: 572546:ARCPR_RS04055
uniprot id: D2RHV2
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

572546:ARCPR RS02270
gene id: 572546:ARCPR_RS02270
uniprot id: D2RGU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

572546:ARCPR RS03735
gene id: 572546:ARCPR_RS03735
uniprot id: D2RHN9
names: Similarity
messages: Belongs to the AAA ATPase family.

572546:ARCPR RS06730
gene id: 572546:ARCPR_RS06730
uniprot id: D2RE46
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

572546:ARCPR RS04755
gene id: 572546:ARCPR_RS04755
uniprot id: D2RI89
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

572546:ARCPR RS07300
gene id: 572546:ARCPR_RS07300
uniprot id: D2REF9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

572546:ARCPR RS07165
gene id: 572546:ARCPR_RS07165
uniprot id: D2RED4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

572546:ARCPR RS05410
gene id: 572546:ARCPR_RS05410
uniprot id: D2RDE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

572546:ARCPR RS05305
gene id: 572546:ARCPR_RS05305
uniprot id: D2RDC3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

572546:ARCPR RS07785
gene id: 572546:ARCPR_RS07785
uniprot id: D2RER0
names: Similarity
messages: Belongs to the peptidase M20A family.

572546:ARCPR RS04935
gene id: 572546:ARCPR_RS04935
uniprot id: D2RIC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

572546:ARCPR RS06415
gene id: 572546:ARCPR_RS06415
uniprot id: D2RDY6
names: Similarity
messages: Belongs to the RuvB family.

572546:ARCPR RS02015
gene id: 572546:ARCPR_RS02015
uniprot id: D2RGP3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

572546:ARCPR RS08225
gene id: 572546:ARCPR_RS08225
uniprot id: D2REZ7
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572546:ARCPR RS07820
gene id: 572546:ARCPR_RS07820
uniprot id: D2RER6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

572546:ARCPR RS07755
gene id: 572546:ARCPR_RS07755
uniprot id: P84624
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MvhD/VhuD family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cytoplasm
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr).

572546:ARCPR RS02990
gene id: 572546:ARCPR_RS02990
uniprot id: D2RH87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

572546:ARCPR RS06245
gene id: 572546:ARCPR_RS06245
uniprot id: D2RDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

572546:ARCPR RS02635
gene id: 572546:ARCPR_RS02635
uniprot id: D2RH16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS01240
gene id: 572546:ARCPR_RS01240
uniprot id: D2RG94
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

572546:ARCPR RS03265
gene id: 572546:ARCPR_RS03265
uniprot id: D2RHE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

572546:ARCPR RS04610
gene id: 572546:ARCPR_RS04610
uniprot id: D2RI62
names: Function
names: Subunit
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.

572546:ARCPR RS00420
gene id: 572546:ARCPR_RS00420
uniprot id: D2RFT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS04035
gene id: 572546:ARCPR_RS04035
uniprot id: D2RHU8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

572546:ARCPR RS02430
gene id: 572546:ARCPR_RS02430
uniprot id: D2RGX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

572546:ARCPR RS00275
gene id: 572546:ARCPR_RS00275
uniprot id: D2RFQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

572546:ARCPR RS05020
gene id: 572546:ARCPR_RS05020
uniprot id: D2RD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

572546:ARCPR RS03290
gene id: 572546:ARCPR_RS03290
uniprot id: D2RHF0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS05365
gene id: 572546:ARCPR_RS05365
uniprot id: D2RDD5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

572546:ARCPR RS00380
gene id: 572546:ARCPR_RS00380
uniprot id: D2RFS9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

572546:ARCPR RS06770
gene id: 572546:ARCPR_RS06770
uniprot id: D2RE54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

572546:ARCPR RS00435
gene id: 572546:ARCPR_RS00435
uniprot id: D2RFU1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

572546:ARCPR RS01325
gene id: 572546:ARCPR_RS01325
uniprot id: D2RGB1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

572546:ARCPR RS07770
gene id: 572546:ARCPR_RS07770
uniprot id: P84626
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: Cytoplasm
messages: Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.
messages: The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

572546:ARCPR RS01185
gene id: 572546:ARCPR_RS01185
uniprot id: D2RG84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS04335
gene id: 572546:ARCPR_RS04335
uniprot id: D2RI11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

572546:ARCPR RS05635
gene id: 572546:ARCPR_RS05635
uniprot id: D2RDI7
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

572546:ARCPR RS03830
gene id: 572546:ARCPR_RS03830
uniprot id: D2RHQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

572546:ARCPR RS04330
gene id: 572546:ARCPR_RS04330
uniprot id: D2RI10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

572546:ARCPR RS00925
gene id: 572546:ARCPR_RS00925
uniprot id: D2RG32
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

572546:ARCPR RS03825
gene id: 572546:ARCPR_RS03825
uniprot id: D2RHQ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

572546:ARCPR RS01125
gene id: 572546:ARCPR_RS01125
uniprot id: D2RG72
names: Similarity
messages: Belongs to the UPF0248 family.

572546:ARCPR RS02090
gene id: 572546:ARCPR_RS02090
uniprot id: D2RGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

572546:ARCPR RS05165
gene id: 572546:ARCPR_RS05165
uniprot id: D2RD96
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

572546:ARCPR RS03445
gene id: 572546:ARCPR_RS03445
uniprot id: D2RHH9
names: Similarity
messages: Belongs to the UPF0107 family.

572546:ARCPR RS01085
gene id: 572546:ARCPR_RS01085
uniprot id: D2RG63
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

572546:ARCPR RS06440
gene id: 572546:ARCPR_RS06440
uniprot id: D2RDZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

572546:ARCPR RS08665
gene id: 572546:ARCPR_RS08665
uniprot id: D2RF87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

572546:ARCPR RS05180
gene id: 572546:ARCPR_RS05180
uniprot id: D2RD99
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

572546:ARCPR RS01900
gene id: 572546:ARCPR_RS01900
uniprot id: D2RGM2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

572546:ARCPR RS00850
gene id: 572546:ARCPR_RS00850
uniprot id: D2RG17
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

572546:ARCPR RS01150
gene id: 572546:ARCPR_RS01150
uniprot id: D2RG77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

572546:ARCPR RS07325
gene id: 572546:ARCPR_RS07325
uniprot id: D2REG4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS03160
gene id: 572546:ARCPR_RS03160
uniprot id: D2RHC3
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

572546:ARCPR RS03630
gene id: 572546:ARCPR_RS03630
uniprot id: D2RHL6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

572546:ARCPR RS03105
gene id: 572546:ARCPR_RS03105
uniprot id: D2RHB2
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

572546:ARCPR RS03780
gene id: 572546:ARCPR_RS03780
uniprot id: D2RHP8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

572546:ARCPR RS01590
gene id: 572546:ARCPR_RS01590
uniprot id: D2RGG4
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

572546:ARCPR RS02720
gene id: 572546:ARCPR_RS02720
uniprot id: D2RH34
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

572546:ARCPR RS06315
gene id: 572546:ARCPR_RS06315
uniprot id: D2RDW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

572546:ARCPR RS00685
gene id: 572546:ARCPR_RS00685
uniprot id: D2RFY5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572546:ARCPR RS04000
gene id: 572546:ARCPR_RS04000
uniprot id: D2RHU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

572546:ARCPR RS01025
gene id: 572546:ARCPR_RS01025
uniprot id: D2RG51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

572546:ARCPR RS06735
gene id: 572546:ARCPR_RS06735
uniprot id: D2RE47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

572546:ARCPR RS00390
gene id: 572546:ARCPR_RS00390
uniprot id: D2RFT1
names: Similarity
messages: Belongs to the AOR/FOR family.

572546:ARCPR RS04960
gene id: 572546:ARCPR_RS04960
uniprot id: D2RD60
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

572546:ARCPR RS00360
gene id: 572546:ARCPR_RS00360
uniprot id: D2RFS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

572546:ARCPR RS02145
gene id: 572546:ARCPR_RS02145
uniprot id: D2RGS0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS04085
gene id: 572546:ARCPR_RS04085
uniprot id: D2RHV8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572546:ARCPR RS06795
gene id: 572546:ARCPR_RS06795
uniprot id: D2RE59
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

572546:ARCPR RS06790
gene id: 572546:ARCPR_RS06790
uniprot id: D2RE58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

572546:ARCPR RS06290
gene id: 572546:ARCPR_RS06290
uniprot id: D2RDW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

572546:ARCPR RS02115
gene id: 572546:ARCPR_RS02115
uniprot id: D2RGR3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS06785
gene id: 572546:ARCPR_RS06785
uniprot id: D2RE57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS08840
gene id: 572546:ARCPR_RS08840
uniprot id: D2RFC1
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

572546:ARCPR RS07790
gene id: 572546:ARCPR_RS07790
uniprot id: D2RER1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

572546:ARCPR RS01620
gene id: 572546:ARCPR_RS01620
uniprot id: D2RGH0
names: Similarity
messages: Belongs to the arsA ATPase family.

572546:ARCPR RS09645
gene id: 572546:ARCPR_RS09645
uniprot id: D2RE63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

572546:ARCPR RS01650
gene id: 572546:ARCPR_RS01650
uniprot id: D2RGH6
names: Similarity
messages: Belongs to the SUI1 family.

572546:ARCPR RS03015
gene id: 572546:ARCPR_RS03015
uniprot id: D2RH92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

572546:ARCPR RS05460
gene id: 572546:ARCPR_RS05460
uniprot id: D2RDF4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

572546:ARCPR RS02240
gene id: 572546:ARCPR_RS02240
uniprot id: D2RGT8
names: Similarity
messages: Belongs to the UPF0146 family.

572546:ARCPR RS00260
gene id: 572546:ARCPR_RS00260
uniprot id: D2RFQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

572546:ARCPR RS01630
gene id: 572546:ARCPR_RS01630
uniprot id: D2RGH2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

572546:ARCPR RS06035
gene id: 572546:ARCPR_RS06035
uniprot id: D2RDR3
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS04895
gene id: 572546:ARCPR_RS04895
uniprot id: D2RIB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

572546:ARCPR RS01930
gene id: 572546:ARCPR_RS01930
uniprot id: D2RGM8
names: Similarity
messages: Belongs to the UPF0047 family.

572546:ARCPR RS07955
gene id: 572546:ARCPR_RS07955
uniprot id: D2REU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS01385
gene id: 572546:ARCPR_RS01385
uniprot id: D2RGC3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

572546:ARCPR RS05070
gene id: 572546:ARCPR_RS05070
uniprot id: D2RD80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572546:ARCPR RS06720
gene id: 572546:ARCPR_RS06720
uniprot id: D2RE44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS00815
gene id: 572546:ARCPR_RS00815
uniprot id: D2RG10
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS03520
gene id: 572546:ARCPR_RS03520
uniprot id: D2RHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

572546:ARCPR RS05135
gene id: 572546:ARCPR_RS05135
uniprot id: D2RD90
names: Similarity
messages: Belongs to the peptidase U62 family.

572546:ARCPR RS01655
gene id: 572546:ARCPR_RS01655
uniprot id: D2RGH7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS02725
gene id: 572546:ARCPR_RS02725
uniprot id: D2RH35
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS08680
gene id: 572546:ARCPR_RS08680
uniprot id: D2RF90
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

572546:ARCPR RS07340
gene id: 572546:ARCPR_RS07340
uniprot id: D2REG8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

572546:ARCPR RS05225
gene id: 572546:ARCPR_RS05225
uniprot id: D2RDA8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

572546:ARCPR RS07050
gene id: 572546:ARCPR_RS07050
uniprot id: D2REB1
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

572546:ARCPR RS03965
gene id: 572546:ARCPR_RS03965
uniprot id: D2RHT4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

572546:ARCPR RS06635
gene id: 572546:ARCPR_RS06635
uniprot id: D2RE26
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS06510
gene id: 572546:ARCPR_RS06510
uniprot id: D2RE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

572546:ARCPR RS06525
gene id: 572546:ARCPR_RS06525
uniprot id: D2RE07
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

572546:ARCPR RS05480
gene id: 572546:ARCPR_RS05480
uniprot id: D2RDF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

572546:ARCPR RS05535
gene id: 572546:ARCPR_RS05535
uniprot id: D2RDG8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

572546:ARCPR RS02555
gene id: 572546:ARCPR_RS02555
uniprot id: D2RH00
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

572546:ARCPR RS06240
gene id: 572546:ARCPR_RS06240
uniprot id: D2RDV2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

572546:ARCPR RS03960
gene id: 572546:ARCPR_RS03960
uniprot id: D2RHT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

572546:ARCPR RS01510
gene id: 572546:ARCPR_RS01510
uniprot id: D2RGE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

572546:ARCPR RS03395
gene id: 572546:ARCPR_RS03395
uniprot id: D2RHG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

572546:ARCPR RS04945
gene id: 572546:ARCPR_RS04945
uniprot id: D2RD57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

572546:ARCPR RS05150
gene id: 572546:ARCPR_RS05150
uniprot id: D2RD93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS00750
gene id: 572546:ARCPR_RS00750
uniprot id: D2RFZ8
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS02665
gene id: 572546:ARCPR_RS02665
uniprot id: D2RH22
names: Similarity
messages: Belongs to the class-I fumarase family.

572546:ARCPR RS02900
gene id: 572546:ARCPR_RS02900
uniprot id: D2RH69
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

572546:ARCPR RS01065
gene id: 572546:ARCPR_RS01065
uniprot id: D2RG59
names: Similarity
messages: Belongs to the TrpC family.

572546:ARCPR RS03415
gene id: 572546:ARCPR_RS03415
uniprot id: D2RHH3
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS07765
gene id: 572546:ARCPR_RS07765
uniprot id: P84621
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrC family.
messages: Cytoplasm
messages: Has oxidoreductase activity. The Hdl and Mvh subunits may together mediate electron transfer from hydrogen to an unidentified electron acceptor on the cytoplasmic side of the membrane.
messages: The heterodisulfide reductase is composed of three subunits; HdlA, HdlB and HdlC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

572546:ARCPR RS08010
gene id: 572546:ARCPR_RS08010
uniprot id: D2REV2
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS06765
gene id: 572546:ARCPR_RS06765
uniprot id: D2RE53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

572546:ARCPR RS01075
gene id: 572546:ARCPR_RS01075
uniprot id: D2RG61
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS02075
gene id: 572546:ARCPR_RS02075
uniprot id: D2RGQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS06675
gene id: 572546:ARCPR_RS06675
uniprot id: D2RE34
names: Similarity
messages: Belongs to the CutA family.

572546:ARCPR RS09045
gene id: 572546:ARCPR_RS09045
uniprot id: D2RFG2
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS07750
gene id: 572546:ARCPR_RS07750
uniprot id: P84627
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Cytoplasm
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (Hdr).

572546:ARCPR RS03540
gene id: 572546:ARCPR_RS03540
uniprot id: D2RHJ8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

572546:ARCPR RS05700
gene id: 572546:ARCPR_RS05700
uniprot id: D2RDJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

572546:ARCPR RS05720
gene id: 572546:ARCPR_RS05720
uniprot id: D2RDK3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

572546:ARCPR RS07180
gene id: 572546:ARCPR_RS07180
uniprot id: D2RED6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

572546:ARCPR RS00785
gene id: 572546:ARCPR_RS00785
uniprot id: D2RG04
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

572546:ARCPR RS03935
gene id: 572546:ARCPR_RS03935
uniprot id: D2RHS9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS07270
gene id: 572546:ARCPR_RS07270
uniprot id: D2REF4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572546:ARCPR RS03650
gene id: 572546:ARCPR_RS03650
uniprot id: D2RHM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

572546:ARCPR RS05420
gene id: 572546:ARCPR_RS05420
uniprot id: D2RDE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

572546:ARCPR RS06470
gene id: 572546:ARCPR_RS06470
uniprot id: D2RDZ6
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS05155
gene id: 572546:ARCPR_RS05155
uniprot id: D2RD94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572546:ARCPR RS07940
gene id: 572546:ARCPR_RS07940
uniprot id: D2RET9
names: Similarity
messages: Belongs to the SHMT family.

572546:ARCPR RS08235
gene id: 572546:ARCPR_RS08235
uniprot id: D2REZ9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

572546:ARCPR RS04990
gene id: 572546:ARCPR_RS04990
uniprot id: D2RD65
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572546:ARCPR RS00500
gene id: 572546:ARCPR_RS00500
uniprot id: D2RFV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

572546:ARCPR RS01600
gene id: 572546:ARCPR_RS01600
uniprot id: D2RGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

572546:ARCPR RS02095
gene id: 572546:ARCPR_RS02095
uniprot id: D2RGQ9
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS00655
gene id: 572546:ARCPR_RS00655
uniprot id: D2RFY0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

572546:ARCPR RS06725
gene id: 572546:ARCPR_RS06725
uniprot id: D2RE45
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

572546:ARCPR RS05170
gene id: 572546:ARCPR_RS05170
uniprot id: D2RD97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

572546:ARCPR RS02480
gene id: 572546:ARCPR_RS02480
uniprot id: D2RGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

572546:ARCPR RS08215
gene id: 572546:ARCPR_RS08215
uniprot id: D2REZ5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572546:ARCPR RS00950
gene id: 572546:ARCPR_RS00950
uniprot id: D2RG37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

572546:ARCPR RS08655
gene id: 572546:ARCPR_RS08655
uniprot id: D2RF85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

572546:ARCPR RS03980
gene id: 572546:ARCPR_RS03980
uniprot id: D2RHT7
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

572546:ARCPR RS04320
gene id: 572546:ARCPR_RS04320
uniprot id: D2RI08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

572546:ARCPR RS06370
gene id: 572546:ARCPR_RS06370
uniprot id: D2RDX8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

572546:ARCPR RS09345
gene id: 572546:ARCPR_RS09345
uniprot id: D2RHY7
names: Similarity
messages: Belongs to the peptidase S8 family.

572546:ARCPR RS07965
gene id: 572546:ARCPR_RS07965
uniprot id: D2REU4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

572546:ARCPR RS00005
gene id: 572546:ARCPR_RS00005
uniprot id: D2RFK4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

572546:ARCPR RS05400
gene id: 572546:ARCPR_RS05400
uniprot id: D2RDE2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

572546:ARCPR RS09205
gene id: 572546:ARCPR_RS09205
uniprot id: D2RFJ5
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS09100
gene id: 572546:ARCPR_RS09100
uniprot id: D2RFH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

572546:ARCPR RS07135
gene id: 572546:ARCPR_RS07135
uniprot id: D2REC8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

572546:ARCPR RS04900
gene id: 572546:ARCPR_RS04900
uniprot id: D2RIB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS04680
gene id: 572546:ARCPR_RS04680
uniprot id: D2RI75
names: Similarity
messages: Belongs to the UPF0212 family.

572546:ARCPR RS02740
gene id: 572546:ARCPR_RS02740
uniprot id: D2RH38
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

572546:ARCPR RS08480
gene id: 572546:ARCPR_RS08480
uniprot id: D2RF51
names: Similarity
messages: Belongs to the MCM family.

572546:ARCPR RS06760
gene id: 572546:ARCPR_RS06760
uniprot id: D2RE52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

572546:ARCPR RS01280
gene id: 572546:ARCPR_RS01280
uniprot id: D2RGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

572546:ARCPR RS00960
gene id: 572546:ARCPR_RS00960
uniprot id: D2RG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS01935
gene id: 572546:ARCPR_RS01935
uniprot id: D2RGM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

572546:ARCPR RS02785
gene id: 572546:ARCPR_RS02785
uniprot id: D2RH46
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS01285
gene id: 572546:ARCPR_RS01285
uniprot id: D2RGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

572546:ARCPR RS05565
gene id: 572546:ARCPR_RS05565
uniprot id: D2RDH4
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS07190
gene id: 572546:ARCPR_RS07190
uniprot id: D2RED8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572546:ARCPR RS05525
gene id: 572546:ARCPR_RS05525
uniprot id: D2RDG6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

572546:ARCPR RS03680
gene id: 572546:ARCPR_RS03680
uniprot id: D2RHM8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

572546:ARCPR RS04885
gene id: 572546:ARCPR_RS04885
uniprot id: D2RIB6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

572546:ARCPR RS08090
gene id: 572546:ARCPR_RS08090
uniprot id: D2REX0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

572546:ARCPR RS01405
gene id: 572546:ARCPR_RS01405
uniprot id: D2RGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

572546:ARCPR RS08975
gene id: 572546:ARCPR_RS08975
uniprot id: D2RFE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

572546:ARCPR RS06940
gene id: 572546:ARCPR_RS06940
uniprot id: D2RE89
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS02325
gene id: 572546:ARCPR_RS02325
uniprot id: D2RGV3
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS01020
gene id: 572546:ARCPR_RS01020
uniprot id: D2RG50
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS03880
gene id: 572546:ARCPR_RS03880
uniprot id: D2RHR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

572546:ARCPR RS03020
gene id: 572546:ARCPR_RS03020
uniprot id: D2RH93
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

572546:ARCPR RS04050
gene id: 572546:ARCPR_RS04050
uniprot id: D2RHV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

572546:ARCPR RS09095
gene id: 572546:ARCPR_RS09095
uniprot id: D2RFH2
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

572546:ARCPR RS06575
gene id: 572546:ARCPR_RS06575
uniprot id: D2RE14
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

572546:ARCPR RS01235
gene id: 572546:ARCPR_RS01235
uniprot id: D2RG93
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

572546:ARCPR RS04950
gene id: 572546:ARCPR_RS04950
uniprot id: D2RD58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572546:ARCPR RS07910
gene id: 572546:ARCPR_RS07910
uniprot id: D2RET3
names: Subcellular Location Annotation
messages: Membrane

572546:ARCPR RS10025
gene id: 572546:ARCPR_RS10025
uniprot id: D2REH1
names: Similarity
messages: Belongs to the NAD synthetase family.