572478:VDIS RS10210
gene id: 572478:VDIS_RS10210
uniprot id: E1QPF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS02890
gene id: 572478:VDIS_RS02890
uniprot id: E1QUY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

572478:VDIS RS09770
gene id: 572478:VDIS_RS09770
uniprot id: E1QNZ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

572478:VDIS RS03155
gene id: 572478:VDIS_RS03155
uniprot id: E1QVB4
names: Similarity
messages: Belongs to the SUI1 family.

572478:VDIS RS02095
gene id: 572478:VDIS_RS02095
uniprot id: E1QU32
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

572478:VDIS RS04880
gene id: 572478:VDIS_RS04880
uniprot id: E1QQ08
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

572478:VDIS RS11655
gene id: 572478:VDIS_RS11655
uniprot id: E1QR48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

572478:VDIS RS00375
gene id: 572478:VDIS_RS00375
uniprot id: E1QS96
names: Similarity
messages: Belongs to the AOR/FOR family.

572478:VDIS RS01680
gene id: 572478:VDIS_RS01680
uniprot id: E1QTN4
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

572478:VDIS RS03260
gene id: 572478:VDIS_RS03260
uniprot id: E1QVD3
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS02825
gene id: 572478:VDIS_RS02825
uniprot id: E1QUX4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

572478:VDIS RS07170
gene id: 572478:VDIS_RS07170
uniprot id: E1QSX6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

572478:VDIS RS07490
gene id: 572478:VDIS_RS07490
uniprot id: E1QTB4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

572478:VDIS RS11990
gene id: 572478:VDIS_RS11990
uniprot id: E1QRI7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

572478:VDIS RS03145
gene id: 572478:VDIS_RS03145
uniprot id: E1QVB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

572478:VDIS RS01650
gene id: 572478:VDIS_RS01650
uniprot id: E1QTM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS06540
gene id: 572478:VDIS_RS06540
uniprot id: E1QS02
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572478:VDIS RS00950
gene id: 572478:VDIS_RS00950
uniprot id: E1QST9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS09880
gene id: 572478:VDIS_RS09880
uniprot id: E1QP14
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

572478:VDIS RS01375
gene id: 572478:VDIS_RS01375
uniprot id: E1QT95
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS11180
gene id: 572478:VDIS_RS11180
uniprot id: E1QQM9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

572478:VDIS RS10050
gene id: 572478:VDIS_RS10050
uniprot id: E1QPC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

572478:VDIS RS08830
gene id: 572478:VDIS_RS08830
uniprot id: E1QUP5
names: Similarity
messages: Belongs to the acylphosphatase family.

572478:VDIS RS04510
gene id: 572478:VDIS_RS04510
uniprot id: E1QPK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

572478:VDIS RS00980
gene id: 572478:VDIS_RS00980
uniprot id: E1QSU6
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

572478:VDIS RS09360
gene id: 572478:VDIS_RS09360
uniprot id: E1QNI4
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS07940
gene id: 572478:VDIS_RS07940
uniprot id: E1QTS7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS04190
gene id: 572478:VDIS_RS04190
uniprot id: E1QP68
names: Similarity
messages: Belongs to the SDO1/SBDS family.

572478:VDIS RS03235
gene id: 572478:VDIS_RS03235
uniprot id: E1QVC8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

572478:VDIS RS03705
gene id: 572478:VDIS_RS03705
uniprot id: E1QNP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

572478:VDIS RS11745
gene id: 572478:VDIS_RS11745
uniprot id: E1QR66
names: Similarity
messages: Belongs to the PGI/PMI family.

572478:VDIS RS02365
gene id: 572478:VDIS_RS02365
uniprot id: E1QUF9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

572478:VDIS RS11440
gene id: 572478:VDIS_RS11440
uniprot id: E1QQT2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

572478:VDIS RS06025
gene id: 572478:VDIS_RS06025
uniprot id: E1QRB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

572478:VDIS RS07990
gene id: 572478:VDIS_RS07990
uniprot id: E1QTT5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS11315
gene id: 572478:VDIS_RS11315
uniprot id: E1QQQ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS10135
gene id: 572478:VDIS_RS10135
uniprot id: E1QPE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

572478:VDIS RS04500
gene id: 572478:VDIS_RS04500
uniprot id: E1QPK6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS03010
gene id: 572478:VDIS_RS03010
uniprot id: E1QV86
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS12160
gene id: 572478:VDIS_RS12160
uniprot id: E1QRM1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS10925
gene id: 572478:VDIS_RS10925
uniprot id: E1QQA1
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS05885
gene id: 572478:VDIS_RS05885
uniprot id: E1QR14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS08795
gene id: 572478:VDIS_RS08795
uniprot id: E1QUN8
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

572478:VDIS RS00765
gene id: 572478:VDIS_RS00765
uniprot id: E1QSP8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

572478:VDIS RS08520
gene id: 572478:VDIS_RS08520
uniprot id: E1QUA8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

572478:VDIS RS10790
gene id: 572478:VDIS_RS10790
uniprot id: E1QQ73
names: Similarity
messages: Belongs to the AOR/FOR family.

572478:VDIS RS05675
gene id: 572478:VDIS_RS05675
uniprot id: E1QQX0
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

572478:VDIS RS05060
gene id: 572478:VDIS_RS05060
uniprot id: E1QQ42
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572478:VDIS RS04755
gene id: 572478:VDIS_RS04755
uniprot id: E1QPQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

572478:VDIS RS03350
gene id: 572478:VDIS_RS03350
uniprot id: E1QNA8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

572478:VDIS RS00430
gene id: 572478:VDIS_RS00430
uniprot id: E1QSA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

572478:VDIS RS03265
gene id: 572478:VDIS_RS03265
uniprot id: E1QVD4
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS11155
gene id: 572478:VDIS_RS11155
uniprot id: E1QQM4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

572478:VDIS RS02040
gene id: 572478:VDIS_RS02040
uniprot id: E1QU21
names: Similarity
messages: Belongs to the Nth/MutY family.

572478:VDIS RS01275
gene id: 572478:VDIS_RS01275
uniprot id: E1QT78
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS06845
gene id: 572478:VDIS_RS06845
uniprot id: E1QSI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

572478:VDIS RS05485
gene id: 572478:VDIS_RS05485
uniprot id: E1QQK5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572478:VDIS RS02175
gene id: 572478:VDIS_RS02175
uniprot id: E1QUB9
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS06470
gene id: 572478:VDIS_RS06470
uniprot id: E1QRY8
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS08940
gene id: 572478:VDIS_RS08940
uniprot id: E1QUZ4
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

572478:VDIS RS07690
gene id: 572478:VDIS_RS07690
uniprot id: E1QTF4
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS06405
gene id: 572478:VDIS_RS06405
uniprot id: E1QRX6
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS12345
gene id: 572478:VDIS_RS12345
uniprot id: E1QS43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

572478:VDIS RS05085
gene id: 572478:VDIS_RS05085
uniprot id: E1QQ48
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

572478:VDIS RS01510
gene id: 572478:VDIS_RS01510
uniprot id: E1QTK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

572478:VDIS RS04450
gene id: 572478:VDIS_RS04450
uniprot id: E1QPJ5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

572478:VDIS RS10000
gene id: 572478:VDIS_RS10000
uniprot id: E1QP37
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572478:VDIS RS02790
gene id: 572478:VDIS_RS02790
uniprot id: E1QUW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

572478:VDIS RS03990
gene id: 572478:VDIS_RS03990
uniprot id: E1QNV3
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS07980
gene id: 572478:VDIS_RS07980
uniprot id: E1QTT3
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS04625
gene id: 572478:VDIS_RS04625
uniprot id: E1QPN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS03000
gene id: 572478:VDIS_RS03000
uniprot id: E1QV84
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

572478:VDIS RS06780
gene id: 572478:VDIS_RS06780
uniprot id: E1QSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS12200
gene id: 572478:VDIS_RS12200
uniprot id: E1QRN0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

572478:VDIS RS04685
gene id: 572478:VDIS_RS04685
uniprot id: E1QPP4
names: Function
messages: Probably involved in the biogenesis of the ribosome.

572478:VDIS RS06320
gene id: 572478:VDIS_RS06320
uniprot id: E1QRV9
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

572478:VDIS RS08510
gene id: 572478:VDIS_RS08510
uniprot id: E1QUA6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

572478:VDIS RS00130
gene id: 572478:VDIS_RS00130
uniprot id: E1QRR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

572478:VDIS RS02545
gene id: 572478:VDIS_RS02545
uniprot id: E1QUR8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS04680
gene id: 572478:VDIS_RS04680
uniprot id: E1QPP3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS12030
gene id: 572478:VDIS_RS12030
uniprot id: E1QRJ5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS10955
gene id: 572478:VDIS_RS10955
uniprot id: E1QQA8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

572478:VDIS RS02905
gene id: 572478:VDIS_RS02905
uniprot id: E1QV66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

572478:VDIS RS05365
gene id: 572478:VDIS_RS05365
uniprot id: E1QQI1
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS07665
gene id: 572478:VDIS_RS07665
uniprot id: E1QTE9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

572478:VDIS RS09305
gene id: 572478:VDIS_RS09305
uniprot id: E1QNH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

572478:VDIS RS11405
gene id: 572478:VDIS_RS11405
uniprot id: E1QQS5
names: Similarity
messages: Belongs to the HypE family.

572478:VDIS RS03600
gene id: 572478:VDIS_RS03600
uniprot id: E1QNF5
names: Similarity
messages: Belongs to the MEMO1 family.

572478:VDIS RS01280
gene id: 572478:VDIS_RS01280
uniprot id: E1QT79
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

572478:VDIS RS02035
gene id: 572478:VDIS_RS02035
uniprot id: E1QU20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

572478:VDIS RS01595
gene id: 572478:VDIS_RS01595
uniprot id: E1QTL7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

572478:VDIS RS01580
gene id: 572478:VDIS_RS01580
uniprot id: E1QTL4
names: Similarity
messages: Belongs to the RuvB family.

572478:VDIS RS12510
gene id: 572478:VDIS_RS12510
uniprot id: E1QS74
names: Similarity
messages: Belongs to the DMRL synthase family.

572478:VDIS RS09950
gene id: 572478:VDIS_RS09950
uniprot id: E1QP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

572478:VDIS RS02900
gene id: 572478:VDIS_RS02900
uniprot id: E1QV65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

572478:VDIS RS02885
gene id: 572478:VDIS_RS02885
uniprot id: E1QUY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

572478:VDIS RS03020
gene id: 572478:VDIS_RS03020
uniprot id: E1QV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS00085
gene id: 572478:VDIS_RS00085
uniprot id: E1QRQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

572478:VDIS RS09105
gene id: 572478:VDIS_RS09105
uniprot id: E1QV29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

572478:VDIS RS09855
gene id: 572478:VDIS_RS09855
uniprot id: E1QP09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS00410
gene id: 572478:VDIS_RS00410
uniprot id: E1QSA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS04930
gene id: 572478:VDIS_RS04930
uniprot id: E1QQ16
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01985
gene id: 572478:VDIS_RS01985
uniprot id: E1QU10
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS07230
gene id: 572478:VDIS_RS07230
uniprot id: E1QUA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

572478:VDIS RS06355
gene id: 572478:VDIS_RS06355
uniprot id: E1QRW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

572478:VDIS RS06120
gene id: 572478:VDIS_RS06120
uniprot id: E1QRD6
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

572478:VDIS RS05865
gene id: 572478:VDIS_RS05865
uniprot id: E1QR10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

572478:VDIS RS02600
gene id: 572478:VDIS_RS02600
uniprot id: E1QUS9
names: Similarity
messages: Belongs to the peptidase M20A family.

572478:VDIS RS05965
gene id: 572478:VDIS_RS05965
uniprot id: E1QRA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

572478:VDIS RS12305
gene id: 572478:VDIS_RS12305
uniprot id: E1QS35
names: Similarity
messages: Belongs to the UPF0282 family.

572478:VDIS RS10155
gene id: 572478:VDIS_RS10155
uniprot id: E1QPE5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

572478:VDIS RS02585
gene id: 572478:VDIS_RS02585
uniprot id: E1QUS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

572478:VDIS RS00965
gene id: 572478:VDIS_RS00965
uniprot id: E1QSU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

572478:VDIS RS10630
gene id: 572478:VDIS_RS10630
uniprot id: E1QPW8
names: Similarity
messages: Belongs to the BtpA family.

572478:VDIS RS05505
gene id: 572478:VDIS_RS05505
uniprot id: E1QQK9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

572478:VDIS RS01785
gene id: 572478:VDIS_RS01785
uniprot id: E1QTX2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

572478:VDIS RS03410
gene id: 572478:VDIS_RS03410
uniprot id: E1QNB7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

572478:VDIS RS01035
gene id: 572478:VDIS_RS01035
uniprot id: E1QT32
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

572478:VDIS RS07325
gene id: 572478:VDIS_RS07325
uniprot id: E1QT08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

572478:VDIS RS10425
gene id: 572478:VDIS_RS10425
uniprot id: E1QPS5
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

572478:VDIS RS04075
gene id: 572478:VDIS_RS04075
uniprot id: E1QP45
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

572478:VDIS RS07740
gene id: 572478:VDIS_RS07740
uniprot id: E1QTG4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

572478:VDIS RS01360
gene id: 572478:VDIS_RS01360
uniprot id: E1QT92
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

572478:VDIS RS11260
gene id: 572478:VDIS_RS11260
uniprot id: E1QQP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS12080
gene id: 572478:VDIS_RS12080
uniprot id: E1QRK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

572478:VDIS RS02940
gene id: 572478:VDIS_RS02940
uniprot id: E1QV73
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS05895
gene id: 572478:VDIS_RS05895
uniprot id: E1QR89
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

572478:VDIS RS08715
gene id: 572478:VDIS_RS08715
uniprot id: E1QUM2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

572478:VDIS RS11485
gene id: 572478:VDIS_RS11485
uniprot id: E1QQU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

572478:VDIS RS00095
gene id: 572478:VDIS_RS00095
uniprot id: E1QRR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

572478:VDIS RS04495
gene id: 572478:VDIS_RS04495
uniprot id: E1QPK5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

572478:VDIS RS00975
gene id: 572478:VDIS_RS00975
uniprot id: E1QSU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

572478:VDIS RS04415
gene id: 572478:VDIS_RS04415
uniprot id: E1QPB3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

572478:VDIS RS12460
gene id: 572478:VDIS_RS12460
uniprot id: E1QS63
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

572478:VDIS RS08370
gene id: 572478:VDIS_RS08370
uniprot id: E1QU79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

572478:VDIS RS10460
gene id: 572478:VDIS_RS10460
uniprot id: E1QPT2
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS03320
gene id: 572478:VDIS_RS03320
uniprot id: E1QNA2
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

572478:VDIS RS00120
gene id: 572478:VDIS_RS00120
uniprot id: E1QRR5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

572478:VDIS RS12455
gene id: 572478:VDIS_RS12455
uniprot id: E1QS62
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

572478:VDIS RS11025
gene id: 572478:VDIS_RS11025
uniprot id: E1QQC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS10230
gene id: 572478:VDIS_RS10230
uniprot id: E1QPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS04205
gene id: 572478:VDIS_RS04205
uniprot id: E1QP71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

572478:VDIS RS03330
gene id: 572478:VDIS_RS03330
uniprot id: E1QNA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

572478:VDIS RS01730
gene id: 572478:VDIS_RS01730
uniprot id: E1QTP3
names: Subcellular Location Annotation
messages: Cell membrane

572478:VDIS RS01770
gene id: 572478:VDIS_RS01770
uniprot id: E1QTW9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

572478:VDIS RS03730
gene id: 572478:VDIS_RS03730
uniprot id: E1QNQ4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

572478:VDIS RS07375
gene id: 572478:VDIS_RS07375
uniprot id: E1QT18
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

572478:VDIS RS03460
gene id: 572478:VDIS_RS03460
uniprot id: E1QNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

572478:VDIS RS11690
gene id: 572478:VDIS_RS11690
uniprot id: E1QR54
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS03540
gene id: 572478:VDIS_RS03540
uniprot id: E1QNE3
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

572478:VDIS RS01740
gene id: 572478:VDIS_RS01740
uniprot id: E1QTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

572478:VDIS RS09135
gene id: 572478:VDIS_RS09135
uniprot id: E1QV36
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

572478:VDIS RS03605
gene id: 572478:VDIS_RS03605
uniprot id: E1QNF6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

572478:VDIS RS07360
gene id: 572478:VDIS_RS07360
uniprot id: E1QT15
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS07090
gene id: 572478:VDIS_RS07090
uniprot id: E1QSW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS09900
gene id: 572478:VDIS_RS09900
uniprot id: E1QP18
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

572478:VDIS RS03555
gene id: 572478:VDIS_RS03555
uniprot id: E1QNE6
names: Similarity
messages: Belongs to the glutamine synthetase family.

572478:VDIS RS12050
gene id: 572478:VDIS_RS12050
uniprot id: E1QRJ9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

572478:VDIS RS08040
gene id: 572478:VDIS_RS08040
uniprot id: E1QTU5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS08460
gene id: 572478:VDIS_RS08460
uniprot id: E1QU96
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

572478:VDIS RS11645
gene id: 572478:VDIS_RS11645
uniprot id: E1QR46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

572478:VDIS RS04380
gene id: 572478:VDIS_RS04380
uniprot id: E1QPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

572478:VDIS RS04785
gene id: 572478:VDIS_RS04785
uniprot id: E1QPR5
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

572478:VDIS RS04175
gene id: 572478:VDIS_RS04175
uniprot id: E1QP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

572478:VDIS RS05820
gene id: 572478:VDIS_RS05820
uniprot id: E1QQZ9
names: Similarity
messages: Belongs to the UPF0215 family.

572478:VDIS RS10775
gene id: 572478:VDIS_RS10775
uniprot id: E1QQ70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

572478:VDIS RS10160
gene id: 572478:VDIS_RS10160
uniprot id: E1QPE6
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

572478:VDIS RS04590
gene id: 572478:VDIS_RS04590
uniprot id: E1QPM5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS06145
gene id: 572478:VDIS_RS06145
uniprot id: E1QRE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

572478:VDIS RS04700
gene id: 572478:VDIS_RS04700
uniprot id: E1QPP7
names: Similarity
messages: Belongs to the UPF0440 family.

572478:VDIS RS09000
gene id: 572478:VDIS_RS09000
uniprot id: E1QV06
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

572478:VDIS RS03365
gene id: 572478:VDIS_RS03365
uniprot id: E1QNB1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS08400
gene id: 572478:VDIS_RS08400
uniprot id: E1QU85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS09625
gene id: 572478:VDIS_RS09625
uniprot id: E1QNN8
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

572478:VDIS RS12225
gene id: 572478:VDIS_RS12225
uniprot id: E1QRN5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS04125
gene id: 572478:VDIS_RS04125
uniprot id: E1QP55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

572478:VDIS RS04610
gene id: 572478:VDIS_RS04610
uniprot id: E1QPM9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

572478:VDIS RS03505
gene id: 572478:VDIS_RS03505
uniprot id: E1QND6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS12275
gene id: 572478:VDIS_RS12275
uniprot id: E1QS28
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS00115
gene id: 572478:VDIS_RS00115
uniprot id: E1QRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

572478:VDIS RS11480
gene id: 572478:VDIS_RS11480
uniprot id: E1QQU0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

572478:VDIS RS00190
gene id: 572478:VDIS_RS00190
uniprot id: E1QRS9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: Belongs to the methylmalonyl-CoA epimerase family.

572478:VDIS RS12100
gene id: 572478:VDIS_RS12100
uniprot id: E1QRK9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

572478:VDIS RS12010
gene id: 572478:VDIS_RS12010
uniprot id: E1QRJ1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS01700
gene id: 572478:VDIS_RS01700
uniprot id: E1QTN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

572478:VDIS RS10800
gene id: 572478:VDIS_RS10800
uniprot id: E1QQ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

572478:VDIS RS08345
gene id: 572478:VDIS_RS08345
uniprot id: E1QU73
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

572478:VDIS RS11495
gene id: 572478:VDIS_RS11495
uniprot id: E1QQU3
names: Similarity
messages: Belongs to the Nth/MutY family.

572478:VDIS RS09130
gene id: 572478:VDIS_RS09130
uniprot id: E1QV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

572478:VDIS RS05020
gene id: 572478:VDIS_RS05020
uniprot id: E1QQ34
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

572478:VDIS RS11940
gene id: 572478:VDIS_RS11940
uniprot id: E1QRI0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

572478:VDIS RS06475
gene id: 572478:VDIS_RS06475
uniprot id: E1QRY9
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS09780
gene id: 572478:VDIS_RS09780
uniprot id: E1QNZ4
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS02920
gene id: 572478:VDIS_RS02920
uniprot id: E1QV69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

572478:VDIS RS01625
gene id: 572478:VDIS_RS01625
uniprot id: E1QTM3
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS10165
gene id: 572478:VDIS_RS10165
uniprot id: E1QPE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

572478:VDIS RS06795
gene id: 572478:VDIS_RS06795
uniprot id: E1QSH6
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS03960
gene id: 572478:VDIS_RS03960
uniprot id: E1QNU7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

572478:VDIS RS00265
gene id: 572478:VDIS_RS00265
uniprot id: E1QRU4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

572478:VDIS RS12285
gene id: 572478:VDIS_RS12285
uniprot id: E1QS30
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS02435
gene id: 572478:VDIS_RS02435
uniprot id: E1QUH2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS05910
gene id: 572478:VDIS_RS05910
uniprot id: E1QR92
names: Similarity
messages: Belongs to the CutA family.

572478:VDIS RS11885
gene id: 572478:VDIS_RS11885
uniprot id: E1QRG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

572478:VDIS RS00060
gene id: 572478:VDIS_RS00060
uniprot id: E1QRQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

572478:VDIS RS07825
gene id: 572478:VDIS_RS07825
uniprot id: E1QTQ3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS03875
gene id: 572478:VDIS_RS03875
uniprot id: E1QNT1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

572478:VDIS RS11300
gene id: 572478:VDIS_RS11300
uniprot id: E1QQQ4
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS12205
gene id: 572478:VDIS_RS12205
uniprot id: E1QRN1
names: Similarity
messages: Belongs to the arginase family.

572478:VDIS RS11030
gene id: 572478:VDIS_RS11030
uniprot id: E1QQC3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

572478:VDIS RS04615
gene id: 572478:VDIS_RS04615
uniprot id: E1QPN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

572478:VDIS RS11820
gene id: 572478:VDIS_RS11820
uniprot id: E1QR82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

572478:VDIS RS09335
gene id: 572478:VDIS_RS09335
uniprot id: E1QNI0
names: Similarity
messages: Belongs to the peptidase C56 family.

572478:VDIS RS01590
gene id: 572478:VDIS_RS01590
uniprot id: E1QTL6
names: Similarity
messages: Belongs to the UPF0111 family.

572478:VDIS RS00090
gene id: 572478:VDIS_RS00090
uniprot id: E1QRQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

572478:VDIS RS08665
gene id: 572478:VDIS_RS08665
uniprot id: E1QUL2
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

572478:VDIS RS11395
gene id: 572478:VDIS_RS11395
uniprot id: E1QQS3
names: Similarity
messages: Belongs to the HupF/HypC family.

572478:VDIS RS02540
gene id: 572478:VDIS_RS02540
uniprot id: E1QUR7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

572478:VDIS RS01500
gene id: 572478:VDIS_RS01500
uniprot id: E1QTJ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

572478:VDIS RS01450
gene id: 572478:VDIS_RS01450
uniprot id: E1QTI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

572478:VDIS RS02910
gene id: 572478:VDIS_RS02910
uniprot id: E1QV67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

572478:VDIS RS05430
gene id: 572478:VDIS_RS05430
uniprot id: E1QQJ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

572478:VDIS RS05585
gene id: 572478:VDIS_RS05585
uniprot id: E1QQV0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

572478:VDIS RS07675
gene id: 572478:VDIS_RS07675
uniprot id: E1QTF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

572478:VDIS RS09195
gene id: 572478:VDIS_RS09195
uniprot id: E1QV48
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

572478:VDIS RS10470
gene id: 572478:VDIS_RS10470
uniprot id: E1QPT4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

572478:VDIS RS03380
gene id: 572478:VDIS_RS03380
uniprot id: E1QNB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

572478:VDIS RS02850
gene id: 572478:VDIS_RS02850
uniprot id: E1QUX9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

572478:VDIS RS02645
gene id: 572478:VDIS_RS02645
uniprot id: E1QUT8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

572478:VDIS RS04070
gene id: 572478:VDIS_RS04070
uniprot id: E1QP44
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

572478:VDIS RS00160
gene id: 572478:VDIS_RS00160
uniprot id: E1QRS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572478:VDIS RS00110
gene id: 572478:VDIS_RS00110
uniprot id: E1QRR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

572478:VDIS RS10670
gene id: 572478:VDIS_RS10670
uniprot id: E1QPX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

572478:VDIS RS04375
gene id: 572478:VDIS_RS04375
uniprot id: E1QPA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

572478:VDIS RS03795
gene id: 572478:VDIS_RS03795
uniprot id: E1QNR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

572478:VDIS RS12400
gene id: 572478:VDIS_RS12400
uniprot id: E1QS52
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

572478:VDIS RS11465
gene id: 572478:VDIS_RS11465
uniprot id: E1QQT7
names: Similarity
messages: Belongs to the class-I fumarase family.

572478:VDIS RS09200
gene id: 572478:VDIS_RS09200
uniprot id: E1QV49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

572478:VDIS RS05935
gene id: 572478:VDIS_RS05935
uniprot id: E1QR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

572478:VDIS RS12475
gene id: 572478:VDIS_RS12475
uniprot id: E1QS66
names: Similarity
messages: Belongs to the NadC/ModD family.

572478:VDIS RS02930
gene id: 572478:VDIS_RS02930
uniprot id: E1QV71
names: Similarity
messages: Belongs to the HisA/HisF family.

572478:VDIS RS12135
gene id: 572478:VDIS_RS12135
uniprot id: E1QRL6
names: Similarity
messages: Belongs to the type IA topoisomerase family.

572478:VDIS RS07510
gene id: 572478:VDIS_RS07510
uniprot id: E1QTB8
names: Similarity
messages: Belongs to the peptidase M1 family.

572478:VDIS RS01200
gene id: 572478:VDIS_RS01200
uniprot id: E1QT64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS09150
gene id: 572478:VDIS_RS09150
uniprot id: E1QV39
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

572478:VDIS RS00240
gene id: 572478:VDIS_RS00240
uniprot id: E1QRT9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

572478:VDIS RS04395
gene id: 572478:VDIS_RS04395
uniprot id: E1QPA9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

572478:VDIS RS05170
gene id: 572478:VDIS_RS05170
uniprot id: E1QQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

572478:VDIS RS08070
gene id: 572478:VDIS_RS08070
uniprot id: E1QTV1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

572478:VDIS RS07015
gene id: 572478:VDIS_RS07015
uniprot id: E1QSM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572478:VDIS RS06720
gene id: 572478:VDIS_RS06720
uniprot id: E1QSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

572478:VDIS RS00420
gene id: 572478:VDIS_RS00420
uniprot id: E1QSA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

572478:VDIS RS01540
gene id: 572478:VDIS_RS01540
uniprot id: E1QTK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

572478:VDIS RS12045
gene id: 572478:VDIS_RS12045
uniprot id: E1QRJ8
names: Similarity
messages: Belongs to the SfsA family.

572478:VDIS RS02030
gene id: 572478:VDIS_RS02030
uniprot id: E1QU19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

572478:VDIS RS08755
gene id: 572478:VDIS_RS08755
uniprot id: E1QUN1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

572478:VDIS RS03845
gene id: 572478:VDIS_RS03845
uniprot id: E1QNS6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

572478:VDIS RS11245
gene id: 572478:VDIS_RS11245
uniprot id: E1QQP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

572478:VDIS RS09615
gene id: 572478:VDIS_RS09615
uniprot id: E1QNN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

572478:VDIS RS10015
gene id: 572478:VDIS_RS10015
uniprot id: E1QPB8
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS09515
gene id: 572478:VDIS_RS09515
uniprot id: E1QNL7
names: Similarity
messages: Belongs to the arginase family.

572478:VDIS RS07480
gene id: 572478:VDIS_RS07480
uniprot id: E1QTB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS07900
gene id: 572478:VDIS_RS07900
uniprot id: E1QTR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS12165
gene id: 572478:VDIS_RS12165
uniprot id: E1QRM2
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS00005
gene id: 572478:VDIS_RS00005
uniprot id: E1QRP2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

572478:VDIS RS01455
gene id: 572478:VDIS_RS01455
uniprot id: E1QTJ0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS09955
gene id: 572478:VDIS_RS09955
uniprot id: E1QP28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

572478:VDIS RS09015
gene id: 572478:VDIS_RS09015
uniprot id: E1QV09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

572478:VDIS RS04530
gene id: 572478:VDIS_RS04530
uniprot id: E1QPL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

572478:VDIS RS09465
gene id: 572478:VDIS_RS09465
uniprot id: E1QNK7
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

572478:VDIS RS00075
gene id: 572478:VDIS_RS00075
uniprot id: E1QRQ6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

572478:VDIS RS12310
gene id: 572478:VDIS_RS12310
uniprot id: E1QS36
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

572478:VDIS RS07185
gene id: 572478:VDIS_RS07185
uniprot id: E1QSX9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

572478:VDIS RS02635
gene id: 572478:VDIS_RS02635
uniprot id: E1QUT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

572478:VDIS RS05450
gene id: 572478:VDIS_RS05450
uniprot id: E1QQJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

572478:VDIS RS11015
gene id: 572478:VDIS_RS11015
uniprot id: E1QQC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

572478:VDIS RS09145
gene id: 572478:VDIS_RS09145
uniprot id: E1QV38
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

572478:VDIS RS03945
gene id: 572478:VDIS_RS03945
uniprot id: E1QNU4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

572478:VDIS RS03790
gene id: 572478:VDIS_RS03790
uniprot id: E1QNR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

572478:VDIS RS12090
gene id: 572478:VDIS_RS12090
uniprot id: E1QRK7
names: Similarity
messages: Belongs to the UMP kinase family.

572478:VDIS RS09050
gene id: 572478:VDIS_RS09050
uniprot id: E1QV17
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

572478:VDIS RS03800
gene id: 572478:VDIS_RS03800
uniprot id: E1QNR6
names: Similarity
messages: Belongs to the ZPR1 family.

572478:VDIS RS10860
gene id: 572478:VDIS_RS10860
uniprot id: E1QQ87
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

572478:VDIS RS09710
gene id: 572478:VDIS_RS09710
uniprot id: E1QNY0
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

572478:VDIS RS07095
gene id: 572478:VDIS_RS07095
uniprot id: E1QSW1
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS05890
gene id: 572478:VDIS_RS05890
uniprot id: E1QR15
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

572478:VDIS RS10900
gene id: 572478:VDIS_RS10900
uniprot id: E1QQ96
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS02525
gene id: 572478:VDIS_RS02525
uniprot id: E1QUR4
names: Subcellular Location Annotation
messages: Nucleus

572478:VDIS RS03115
gene id: 572478:VDIS_RS03115
uniprot id: E1QVA7
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS00490
gene id: 572478:VDIS_RS00490
uniprot id: E1QSB8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

572478:VDIS RS11705
gene id: 572478:VDIS_RS11705
uniprot id: E1QR57
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

572478:VDIS RS12270
gene id: 572478:VDIS_RS12270
uniprot id: E1QS27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

572478:VDIS RS03580
gene id: 572478:VDIS_RS03580
uniprot id: E1QNF1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

572478:VDIS RS09410
gene id: 572478:VDIS_RS09410
uniprot id: E1QNJ5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

572478:VDIS RS05960
gene id: 572478:VDIS_RS05960
uniprot id: E1QRA2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

572478:VDIS RS07790
gene id: 572478:VDIS_RS07790
uniprot id: E1QTH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

572478:VDIS RS09415
gene id: 572478:VDIS_RS09415
uniprot id: E1QNJ6
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

572478:VDIS RS10400
gene id: 572478:VDIS_RS10400
uniprot id: E1QPS0
names: Similarity
messages: Belongs to the Ahb/Nir family.

572478:VDIS RS09725
gene id: 572478:VDIS_RS09725
uniprot id: E1QNY3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

572478:VDIS RS07120
gene id: 572478:VDIS_RS07120
uniprot id: E1QSW6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

572478:VDIS RS01390
gene id: 572478:VDIS_RS01390
uniprot id: E1QTH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

572478:VDIS RS06455
gene id: 572478:VDIS_RS06455
uniprot id: E1QRY5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

572478:VDIS RS04575
gene id: 572478:VDIS_RS04575
uniprot id: E1QPM2
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS11205
gene id: 572478:VDIS_RS11205
uniprot id: E1QQN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

572478:VDIS RS11665
gene id: 572478:VDIS_RS11665
uniprot id: E1QR50
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS03685
gene id: 572478:VDIS_RS03685
uniprot id: E1QNP5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

572478:VDIS RS08605
gene id: 572478:VDIS_RS08605
uniprot id: E1QUK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

572478:VDIS RS09715
gene id: 572478:VDIS_RS09715
uniprot id: E1QNY1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS11825
gene id: 572478:VDIS_RS11825
uniprot id: E1QR83
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS09785
gene id: 572478:VDIS_RS09785
uniprot id: E1QNZ5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

572478:VDIS RS00425
gene id: 572478:VDIS_RS00425
uniprot id: E1QSA6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

572478:VDIS RS12335
gene id: 572478:VDIS_RS12335
uniprot id: E1QS41
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

572478:VDIS RS12105
gene id: 572478:VDIS_RS12105
uniprot id: E1QRL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

572478:VDIS RS05315
gene id: 572478:VDIS_RS05315
uniprot id: E1QQH1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

572478:VDIS RS04410
gene id: 572478:VDIS_RS04410
uniprot id: E1QPB2
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

572478:VDIS RS02430
gene id: 572478:VDIS_RS02430
uniprot id: E1QUH1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS04000
gene id: 572478:VDIS_RS04000
uniprot id: E1QNV5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

572478:VDIS RS07495
gene id: 572478:VDIS_RS07495
uniprot id: E1QTB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS04645
gene id: 572478:VDIS_RS04645
uniprot id: E1QPN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS00020
gene id: 572478:VDIS_RS00020
uniprot id: E1QRP5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

572478:VDIS RS11890
gene id: 572478:VDIS_RS11890
uniprot id: E1QRH0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

572478:VDIS RS01810
gene id: 572478:VDIS_RS01810
uniprot id: E1QTX7
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

572478:VDIS RS01095
gene id: 572478:VDIS_RS01095
uniprot id: E1QT44
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

572478:VDIS RS08525
gene id: 572478:VDIS_RS08525
uniprot id: E1QUA9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

572478:VDIS RS12395
gene id: 572478:VDIS_RS12395
uniprot id: E1QS51
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

572478:VDIS RS07285
gene id: 572478:VDIS_RS07285
uniprot id: E1QSZ8
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

572478:VDIS RS02530
gene id: 572478:VDIS_RS02530
uniprot id: E1QUR5
names: Similarity
messages: Belongs to the MCM family.

572478:VDIS RS01925
gene id: 572478:VDIS_RS01925
uniprot id: E1QTZ8
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

572478:VDIS RS06115
gene id: 572478:VDIS_RS06115
uniprot id: E1QRD5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

572478:VDIS RS10960
gene id: 572478:VDIS_RS10960
uniprot id: E1QQA9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

572478:VDIS RS01515
gene id: 572478:VDIS_RS01515
uniprot id: E1QTK2
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

572478:VDIS RS11010
gene id: 572478:VDIS_RS11010
uniprot id: E1QQB8
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS10145
gene id: 572478:VDIS_RS10145
uniprot id: E1QPE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS08985
gene id: 572478:VDIS_RS08985
uniprot id: E1QV03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

572478:VDIS RS09190
gene id: 572478:VDIS_RS09190
uniprot id: E1QV47
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

572478:VDIS RS01495
gene id: 572478:VDIS_RS01495
uniprot id: E1QTJ8
names: Similarity
messages: Belongs to the UPF0200 family.

572478:VDIS RS11850
gene id: 572478:VDIS_RS11850
uniprot id: E1QR88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS03720
gene id: 572478:VDIS_RS03720
uniprot id: E1QNQ2
names: Similarity
messages: Belongs to the TFIIB family.

572478:VDIS RS10105
gene id: 572478:VDIS_RS10105
uniprot id: E1QPD6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

572478:VDIS RS09910
gene id: 572478:VDIS_RS09910
uniprot id: E1QP20
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS10975
gene id: 572478:VDIS_RS10975
uniprot id: E1QQB2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

572478:VDIS RS02625
gene id: 572478:VDIS_RS02625
uniprot id: E1QUT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

572478:VDIS RS07200
gene id: 572478:VDIS_RS07200
uniprot id: E1QSY2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

572478:VDIS RS00100
gene id: 572478:VDIS_RS00100
uniprot id: E1QRR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

572478:VDIS RS09825
gene id: 572478:VDIS_RS09825
uniprot id: E1QP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS04445
gene id: 572478:VDIS_RS04445
uniprot id: E1QPJ4
names: Similarity
messages: Belongs to the UPF0201 family.

572478:VDIS RS03625
gene id: 572478:VDIS_RS03625
uniprot id: E1QNG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS01995
gene id: 572478:VDIS_RS01995
uniprot id: E1QU12
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

572478:VDIS RS08895
gene id: 572478:VDIS_RS08895
uniprot id: E1QUQ7
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

572478:VDIS RS05410
gene id: 572478:VDIS_RS05410
uniprot id: E1QQJ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

572478:VDIS RS01440
gene id: 572478:VDIS_RS01440
uniprot id: E1QTI7
names: Similarity
messages: Belongs to the peptidase M20A family.

572478:VDIS RS08365
gene id: 572478:VDIS_RS08365
uniprot id: E1QU78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

572478:VDIS RS00250
gene id: 572478:VDIS_RS00250
uniprot id: E1QRU1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

572478:VDIS RS11880
gene id: 572478:VDIS_RS11880
uniprot id: E1QRG8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

572478:VDIS RS02950
gene id: 572478:VDIS_RS02950
uniprot id: E1QV75
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

572478:VDIS RS10880
gene id: 572478:VDIS_RS10880
uniprot id: E1QQ92
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

572478:VDIS RS12145
gene id: 572478:VDIS_RS12145
uniprot id: E1QRL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

572478:VDIS RS01110
gene id: 572478:VDIS_RS01110
uniprot id: E1QT47
names: Similarity
messages: Belongs to the TrpF family.

572478:VDIS RS03785
gene id: 572478:VDIS_RS03785
uniprot id: E1QNR3
names: Subcellular Location Annotation
messages: Nucleus

572478:VDIS RS02855
gene id: 572478:VDIS_RS02855
uniprot id: E1QUY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

572478:VDIS RS06850
gene id: 572478:VDIS_RS06850
uniprot id: E1QSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

572478:VDIS RS01060
gene id: 572478:VDIS_RS01060
uniprot id: E1QT37
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS12150
gene id: 572478:VDIS_RS12150
uniprot id: E1QRL9
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572478:VDIS RS11225
gene id: 572478:VDIS_RS11225
uniprot id: E1QQN9
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

572478:VDIS RS11795
gene id: 572478:VDIS_RS11795
uniprot id: E1QR77
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

572478:VDIS RS04045
gene id: 572478:VDIS_RS04045
uniprot id: E1QNW4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

572478:VDIS RS00135
gene id: 572478:VDIS_RS00135
uniprot id: E1QRR8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

572478:VDIS RS10225
gene id: 572478:VDIS_RS10225
uniprot id: E1QPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS06395
gene id: 572478:VDIS_RS06395
uniprot id: E1QRX4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

572478:VDIS RS04780
gene id: 572478:VDIS_RS04780
uniprot id: E1QPR4
names: Similarity
messages: Belongs to the HypE family.

572478:VDIS RS03425
gene id: 572478:VDIS_RS03425
uniprot id: E1QNC0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572478:VDIS RS11455
gene id: 572478:VDIS_RS11455
uniprot id: E1QQT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS09620
gene id: 572478:VDIS_RS09620
uniprot id: E1QNN7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

572478:VDIS RS04170
gene id: 572478:VDIS_RS04170
uniprot id: E1QP64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS09505
gene id: 572478:VDIS_RS09505
uniprot id: E1QNL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

572478:VDIS RS02575
gene id: 572478:VDIS_RS02575
uniprot id: E1QUS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

572478:VDIS RS09600
gene id: 572478:VDIS_RS09600
uniprot id: E1QNN3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

572478:VDIS RS04595
gene id: 572478:VDIS_RS04595
uniprot id: E1QPM6
names: Similarity
messages: Belongs to the malic enzymes family.

572478:VDIS RS12180
gene id: 572478:VDIS_RS12180
uniprot id: E1QRM6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS09990
gene id: 572478:VDIS_RS09990
uniprot id: E1QP35
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

572478:VDIS RS04695
gene id: 572478:VDIS_RS04695
uniprot id: E1QPP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

572478:VDIS RS03585
gene id: 572478:VDIS_RS03585
uniprot id: E1QNF2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS08995
gene id: 572478:VDIS_RS08995
uniprot id: E1QV05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

572478:VDIS RS01155
gene id: 572478:VDIS_RS01155
uniprot id: E1QT56
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

572478:VDIS RS07280
gene id: 572478:VDIS_RS07280
uniprot id: E1QSZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

572478:VDIS RS08035
gene id: 572478:VDIS_RS08035
uniprot id: E1QTU4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS09205
gene id: 572478:VDIS_RS09205
uniprot id: E1QV50
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS07530
gene id: 572478:VDIS_RS07530
uniprot id: E1QTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

572478:VDIS RS07600
gene id: 572478:VDIS_RS07600
uniprot id: E1QTD6
names: Similarity
messages: Belongs to the NodU/CmcH family.

572478:VDIS RS04690
gene id: 572478:VDIS_RS04690
uniprot id: E1QPP5
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

572478:VDIS RS06750
gene id: 572478:VDIS_RS06750
uniprot id: E1QSG8
names: Similarity
messages: Belongs to the peptidase U62 family.

572478:VDIS RS04120
gene id: 572478:VDIS_RS04120
uniprot id: E1QP54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

572478:VDIS RS10115
gene id: 572478:VDIS_RS10115
uniprot id: E1QPD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS01530
gene id: 572478:VDIS_RS01530
uniprot id: E1QTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS09495
gene id: 572478:VDIS_RS09495
uniprot id: E1QNL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS12435
gene id: 572478:VDIS_RS12435
uniprot id: E1QS58
names: Similarity
messages: Belongs to the AOR/FOR family.

572478:VDIS RS12220
gene id: 572478:VDIS_RS12220
uniprot id: E1QRN4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

572478:VDIS RS00170
gene id: 572478:VDIS_RS00170
uniprot id: E1QRS5
names: Similarity
messages: Belongs to the AOR/FOR family.

572478:VDIS RS00270
gene id: 572478:VDIS_RS00270
uniprot id: E1QS77
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS12250
gene id: 572478:VDIS_RS12250
uniprot id: E1QS23
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01395
gene id: 572478:VDIS_RS01395
uniprot id: E1QTH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

572478:VDIS RS08585
gene id: 572478:VDIS_RS08585
uniprot id: E1QUJ6
names: Similarity
messages: Belongs to the peptidase M24B family.

572478:VDIS RS00225
gene id: 572478:VDIS_RS00225
uniprot id: E1QRT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS06515
gene id: 572478:VDIS_RS06515
uniprot id: E1QRZ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

572478:VDIS RS12490
gene id: 572478:VDIS_RS12490
uniprot id: E1QS70
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

572478:VDIS RS01290
gene id: 572478:VDIS_RS01290
uniprot id: E1QT81
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS06570
gene id: 572478:VDIS_RS06570
uniprot id: E1QS08
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

572478:VDIS RS10090
gene id: 572478:VDIS_RS10090
uniprot id: E1QPD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS04900
gene id: 572478:VDIS_RS04900
uniprot id: E1QQ12
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01775
gene id: 572478:VDIS_RS01775
uniprot id: E1QTX0
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

572478:VDIS RS05090
gene id: 572478:VDIS_RS05090
uniprot id: E1QQ49
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

572478:VDIS RS05940
gene id: 572478:VDIS_RS05940
uniprot id: E1QR98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS01090
gene id: 572478:VDIS_RS01090
uniprot id: E1QT43
names: Similarity
messages: Belongs to the TrpC family.

572478:VDIS RS04540
gene id: 572478:VDIS_RS04540
uniprot id: E1QPL5
names: Similarity
messages: Belongs to the glutaredoxin family.

572478:VDIS RS07155
gene id: 572478:VDIS_RS07155
uniprot id: E1QSX3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS10490
gene id: 572478:VDIS_RS10490
uniprot id: E1QPT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

572478:VDIS RS07100
gene id: 572478:VDIS_RS07100
uniprot id: E1QSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

572478:VDIS RS09510
gene id: 572478:VDIS_RS09510
uniprot id: E1QNL6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

572478:VDIS RS02865
gene id: 572478:VDIS_RS02865
uniprot id: E1QUY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

572478:VDIS RS09070
gene id: 572478:VDIS_RS09070
uniprot id: E1QV21
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

572478:VDIS RS00415
gene id: 572478:VDIS_RS00415
uniprot id: E1QSA4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

572478:VDIS RS09405
gene id: 572478:VDIS_RS09405
uniprot id: E1QNJ4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572478:VDIS RS09540
gene id: 572478:VDIS_RS09540
uniprot id: E1QNM2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS01080
gene id: 572478:VDIS_RS01080
uniprot id: E1QT41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572478:VDIS RS11065
gene id: 572478:VDIS_RS11065
uniprot id: E1QQD2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

572478:VDIS RS04095
gene id: 572478:VDIS_RS04095
uniprot id: E1QP49
names: Similarity
messages: Belongs to the UPF0173 family.

572478:VDIS RS02655
gene id: 572478:VDIS_RS02655
uniprot id: E1QUU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

572478:VDIS RS07210
gene id: 572478:VDIS_RS07210
uniprot id: E1QSY4
names: Similarity
messages: Belongs to the thymidylate kinase family.

572478:VDIS RS04635
gene id: 572478:VDIS_RS04635
uniprot id: E1QPN4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS00390
gene id: 572478:VDIS_RS00390
uniprot id: E1QS99
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

572478:VDIS RS10270
gene id: 572478:VDIS_RS10270
uniprot id: E1QPG5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572478:VDIS RS08625
gene id: 572478:VDIS_RS08625
uniprot id: E1QUK4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

572478:VDIS RS01915
gene id: 572478:VDIS_RS01915
uniprot id: E1QTZ6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS01180
gene id: 572478:VDIS_RS01180
uniprot id: E1QT61
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

572478:VDIS RS05435
gene id: 572478:VDIS_RS05435
uniprot id: E1QQJ5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS10855
gene id: 572478:VDIS_RS10855
uniprot id: E1QQ86
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572478:VDIS RS08155
gene id: 572478:VDIS_RS08155
uniprot id: E1QTW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

572478:VDIS RS04105
gene id: 572478:VDIS_RS04105
uniprot id: E1QP51
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

572478:VDIS RS04185
gene id: 572478:VDIS_RS04185
uniprot id: E1QP67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

572478:VDIS RS11350
gene id: 572478:VDIS_RS11350
uniprot id: E1QQR4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

572478:VDIS RS09020
gene id: 572478:VDIS_RS09020
uniprot id: E1QV10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

572478:VDIS RS05720
gene id: 572478:VDIS_RS05720
uniprot id: E1QQX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

572478:VDIS RS02805
gene id: 572478:VDIS_RS02805
uniprot id: E1QUX0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572478:VDIS RS02410
gene id: 572478:VDIS_RS02410
uniprot id: E1QUG8
names: Similarity
messages: Belongs to the AOR/FOR family.

572478:VDIS RS11965
gene id: 572478:VDIS_RS11965
uniprot id: E1QRI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572478:VDIS RS06285
gene id: 572478:VDIS_RS06285
uniprot id: E1QRV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

572478:VDIS RS07160
gene id: 572478:VDIS_RS07160
uniprot id: E1QSX4
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS02935
gene id: 572478:VDIS_RS02935
uniprot id: E1QV72
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

572478:VDIS RS02680
gene id: 572478:VDIS_RS02680
uniprot id: E1QUU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

572478:VDIS RS02870
gene id: 572478:VDIS_RS02870
uniprot id: E1QUY3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS01725
gene id: 572478:VDIS_RS01725
uniprot id: E1QTP2
names: Similarity
messages: Belongs to the glutamate synthase family.

572478:VDIS RS02670
gene id: 572478:VDIS_RS02670
uniprot id: E1QUU3
names: Similarity
messages: Belongs to the UPF0047 family.

572478:VDIS RS10355
gene id: 572478:VDIS_RS10355
uniprot id: E1QPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

572478:VDIS RS09650
gene id: 572478:VDIS_RS09650
uniprot id: E1QNW6
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

572478:VDIS RS06430
gene id: 572478:VDIS_RS06430
uniprot id: E1QRY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS10570
gene id: 572478:VDIS_RS10570
uniprot id: E1QPV6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

572478:VDIS RS10735
gene id: 572478:VDIS_RS10735
uniprot id: E1QPY9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

572478:VDIS RS08970
gene id: 572478:VDIS_RS08970
uniprot id: E1QV00
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

572478:VDIS RS00065
gene id: 572478:VDIS_RS00065
uniprot id: E1QRQ4
names: Similarity
messages: Belongs to the glutaredoxin family.

572478:VDIS RS03525
gene id: 572478:VDIS_RS03525
uniprot id: E1QNE0
names: Similarity
messages: Belongs to the pyruvate kinase family.

572478:VDIS RS09535
gene id: 572478:VDIS_RS09535
uniprot id: E1QNM1
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS06255
gene id: 572478:VDIS_RS06255
uniprot id: E1QRU6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

572478:VDIS RS11470
gene id: 572478:VDIS_RS11470
uniprot id: E1QQT8
names: Similarity
messages: Belongs to the class-I fumarase family.

572478:VDIS RS11505
gene id: 572478:VDIS_RS11505
uniprot id: E1QR17
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

572478:VDIS RS09720
gene id: 572478:VDIS_RS09720
uniprot id: E1QNY2
names: Similarity
messages: Belongs to the UPF0179 family.

572478:VDIS RS01910
gene id: 572478:VDIS_RS01910
uniprot id: E1QTZ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS10235
gene id: 572478:VDIS_RS10235
uniprot id: E1QPF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

572478:VDIS RS10110
gene id: 572478:VDIS_RS10110
uniprot id: E1QPD7
names: Similarity
messages: Belongs to the PDCD5 family.

572478:VDIS RS01385
gene id: 572478:VDIS_RS01385
uniprot id: E1QT97
names: Similarity
messages: Belongs to the thioesterase PaaI family.

572478:VDIS RS01270
gene id: 572478:VDIS_RS01270
uniprot id: E1QT77
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572478:VDIS RS08005
gene id: 572478:VDIS_RS08005
uniprot id: E1QTT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

572478:VDIS RS06100
gene id: 572478:VDIS_RS06100
uniprot id: E1QRD2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS03480
gene id: 572478:VDIS_RS03480
uniprot id: E1QND1
names: Similarity
messages: Belongs to the MoaB/Mog family.

572478:VDIS RS02420
gene id: 572478:VDIS_RS02420
uniprot id: E1QUH0
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

572478:VDIS RS03780
gene id: 572478:VDIS_RS03780
uniprot id: E1QNR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

572478:VDIS RS05970
gene id: 572478:VDIS_RS05970
uniprot id: E1QRA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

572478:VDIS RS08775
gene id: 572478:VDIS_RS08775
uniprot id: E1QUN5
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

572478:VDIS RS09300
gene id: 572478:VDIS_RS09300
uniprot id: E1QNH3
names: Similarity
messages: Belongs to the PrpD family.

572478:VDIS RS04110
gene id: 572478:VDIS_RS04110
uniprot id: E1QP52
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

572478:VDIS RS09775
gene id: 572478:VDIS_RS09775
uniprot id: E1QNZ3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS01780
gene id: 572478:VDIS_RS01780
uniprot id: E1QTX1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572478:VDIS RS00500
gene id: 572478:VDIS_RS00500
uniprot id: E1QSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

572478:VDIS RS02400
gene id: 572478:VDIS_RS02400
uniprot id: E1QUG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

572478:VDIS RS04520
gene id: 572478:VDIS_RS04520
uniprot id: E1QPL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

572478:VDIS RS04545
gene id: 572478:VDIS_RS04545
uniprot id: E1QPL6
names: Similarity
messages: Belongs to the HAM1 NTPase family.

572478:VDIS RS00400
gene id: 572478:VDIS_RS00400
uniprot id: E1QSA1
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

572478:VDIS RS08065
gene id: 572478:VDIS_RS08065
uniprot id: E1QTV0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

572478:VDIS RS06980
gene id: 572478:VDIS_RS06980
uniprot id: E1QSL3
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS05950
gene id: 572478:VDIS_RS05950
uniprot id: E1QRA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS05490
gene id: 572478:VDIS_RS05490
uniprot id: E1QQK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS09380
gene id: 572478:VDIS_RS09380
uniprot id: E1QNI8
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

572478:VDIS RS06920
gene id: 572478:VDIS_RS06920
uniprot id: E1QSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS06645
gene id: 572478:VDIS_RS06645
uniprot id: E1QSE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

572478:VDIS RS02550
gene id: 572478:VDIS_RS02550
uniprot id: E1QUR9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS11005
gene id: 572478:VDIS_RS11005
uniprot id: E1QQB7
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

572478:VDIS RS10150
gene id: 572478:VDIS_RS10150
uniprot id: E1QPE4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

572478:VDIS RS08720
gene id: 572478:VDIS_RS08720
uniprot id: E1QUM3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

572478:VDIS RS03710
gene id: 572478:VDIS_RS03710
uniprot id: E1QNQ0
names: Similarity
messages: Belongs to the carbamate kinase family.

572478:VDIS RS09800
gene id: 572478:VDIS_RS09800
uniprot id: E1QNZ8
names: Similarity
messages: Belongs to the UPF0045 family.

572478:VDIS RS02590
gene id: 572478:VDIS_RS02590
uniprot id: E1QUS7
names: Similarity
messages: Belongs to the UDPGP type 2 family.

572478:VDIS RS10395
gene id: 572478:VDIS_RS10395
uniprot id: E1QPJ1
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS11190
gene id: 572478:VDIS_RS11190
uniprot id: E1QQN2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS09960
gene id: 572478:VDIS_RS09960
uniprot id: E1QP29
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS01125
gene id: 572478:VDIS_RS01125
uniprot id: E1QT50
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

572478:VDIS RS12190
gene id: 572478:VDIS_RS12190
uniprot id: E1QRM8
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS10085
gene id: 572478:VDIS_RS10085
uniprot id: E1QPD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572478:VDIS RS09730
gene id: 572478:VDIS_RS09730
uniprot id: E1QNY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

572478:VDIS RS06775
gene id: 572478:VDIS_RS06775
uniprot id: E1QSH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS09090
gene id: 572478:VDIS_RS09090
uniprot id: E1QV26
names: Similarity
messages: Belongs to the citrate synthase family.

572478:VDIS RS04085
gene id: 572478:VDIS_RS04085
uniprot id: E1QP47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

572478:VDIS RS01805
gene id: 572478:VDIS_RS01805
uniprot id: E1QTX6
names: Subcellular Location Annotation
messages: Cytoplasm

572478:VDIS RS11330
gene id: 572478:VDIS_RS11330
uniprot id: E1QQR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

572478:VDIS RS09320
gene id: 572478:VDIS_RS09320
uniprot id: E1QNH7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

572478:VDIS RS02810
gene id: 572478:VDIS_RS02810
uniprot id: E1QUX1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS00530
gene id: 572478:VDIS_RS00530
uniprot id: E1QSC4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

572478:VDIS RS01160
gene id: 572478:VDIS_RS01160
uniprot id: E1QT57
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

572478:VDIS RS02610
gene id: 572478:VDIS_RS02610
uniprot id: E1QUT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

572478:VDIS RS01070
gene id: 572478:VDIS_RS01070
uniprot id: E1QT39
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS09985
gene id: 572478:VDIS_RS09985
uniprot id: E1QP34
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

572478:VDIS RS03455
gene id: 572478:VDIS_RS03455
uniprot id: E1QNC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS07245
gene id: 572478:VDIS_RS07245
uniprot id: E1QSZ0
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

572478:VDIS RS04440
gene id: 572478:VDIS_RS04440
uniprot id: E1QPJ3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

572478:VDIS RS09180
gene id: 572478:VDIS_RS09180
uniprot id: E1QV45
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS03375
gene id: 572478:VDIS_RS03375
uniprot id: E1QNB3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS05515
gene id: 572478:VDIS_RS05515
uniprot id: E1QQL1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

572478:VDIS RS09400
gene id: 572478:VDIS_RS09400
uniprot id: E1QNJ3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

572478:VDIS RS11160
gene id: 572478:VDIS_RS11160
uniprot id: E1QQM5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

572478:VDIS RS00315
gene id: 572478:VDIS_RS00315
uniprot id: E1QS85
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

572478:VDIS RS10320
gene id: 572478:VDIS_RS10320
uniprot id: E1QPH5
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01260
gene id: 572478:VDIS_RS01260
uniprot id: E1QT75
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

572478:VDIS RS07915
gene id: 572478:VDIS_RS07915
uniprot id: E1QTS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

572478:VDIS RS06050
gene id: 572478:VDIS_RS06050
uniprot id: E1QRC1
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS11215
gene id: 572478:VDIS_RS11215
uniprot id: E1QQN7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

572478:VDIS RS01245
gene id: 572478:VDIS_RS01245
uniprot id: E1QT72
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

572478:VDIS RS03610
gene id: 572478:VDIS_RS03610
uniprot id: E1QNF7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

572478:VDIS RS11335
gene id: 572478:VDIS_RS11335
uniprot id: E1QQR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS01965
gene id: 572478:VDIS_RS01965
uniprot id: E1QU06
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01005
gene id: 572478:VDIS_RS01005
uniprot id: E1QT26
names: Subunit
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

572478:VDIS RS02915
gene id: 572478:VDIS_RS02915
uniprot id: E1QV68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

572478:VDIS RS00040
gene id: 572478:VDIS_RS00040
uniprot id: E1QRP9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

572478:VDIS RS00505
gene id: 572478:VDIS_RS00505
uniprot id: E1QSC1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

572478:VDIS RS10035
gene id: 572478:VDIS_RS10035
uniprot id: E1QPC2
names: Similarity
messages: Belongs to the peptidase M20A family.

572478:VDIS RS06490
gene id: 572478:VDIS_RS06490
uniprot id: E1QRZ2
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS05905
gene id: 572478:VDIS_RS05905
uniprot id: E1QR91
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

572478:VDIS RS06960
gene id: 572478:VDIS_RS06960
uniprot id: E1QSK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

572478:VDIS RS10835
gene id: 572478:VDIS_RS10835
uniprot id: E1QQ82
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

572478:VDIS RS00305
gene id: 572478:VDIS_RS00305
uniprot id: E1QS83
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS04525
gene id: 572478:VDIS_RS04525
uniprot id: E1QPL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS07275
gene id: 572478:VDIS_RS07275
uniprot id: E1QSZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS06950
gene id: 572478:VDIS_RS06950
uniprot id: E1QSK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS12240
gene id: 572478:VDIS_RS12240
uniprot id: E1QRN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

572478:VDIS RS06215
gene id: 572478:VDIS_RS06215
uniprot id: E1QRF7
names: Similarity
messages: Belongs to the complex I subunit 3 family.

572478:VDIS RS01405
gene id: 572478:VDIS_RS01405
uniprot id: E1QTH8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

572478:VDIS RS11780
gene id: 572478:VDIS_RS11780
uniprot id: E1QR73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

572478:VDIS RS10130
gene id: 572478:VDIS_RS10130
uniprot id: E1QPE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

572478:VDIS RS11530
gene id: 572478:VDIS_RS11530
uniprot id: E1QR22
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS11660
gene id: 572478:VDIS_RS11660
uniprot id: E1QR49
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

572478:VDIS RS10030
gene id: 572478:VDIS_RS10030
uniprot id: E1QPC1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

572478:VDIS RS04790
gene id: 572478:VDIS_RS04790
uniprot id: E1QPR6
names: Similarity
messages: Belongs to the RutC family.

572478:VDIS RS00310
gene id: 572478:VDIS_RS00310
uniprot id: E1QS84
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS09735
gene id: 572478:VDIS_RS09735
uniprot id: E1QNY5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572478:VDIS RS04505
gene id: 572478:VDIS_RS04505
uniprot id: E1QPK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572478:VDIS RS08205
gene id: 572478:VDIS_RS08205
uniprot id: E1QU50
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

572478:VDIS RS03415
gene id: 572478:VDIS_RS03415
uniprot id: E1QNB8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS00495
gene id: 572478:VDIS_RS00495
uniprot id: E1QSB9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

572478:VDIS RS08185
gene id: 572478:VDIS_RS08185
uniprot id: E1QU46
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS00990
gene id: 572478:VDIS_RS00990
uniprot id: E1QSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

572478:VDIS RS11195
gene id: 572478:VDIS_RS11195
uniprot id: E1QQN3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS09485
gene id: 572478:VDIS_RS09485
uniprot id: E1QNL1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

572478:VDIS RS10710
gene id: 572478:VDIS_RS10710
uniprot id: E1QPY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

572478:VDIS RS01765
gene id: 572478:VDIS_RS01765
uniprot id: E1QTQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

572478:VDIS RS05920
gene id: 572478:VDIS_RS05920
uniprot id: E1QR94
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS06190
gene id: 572478:VDIS_RS06190
uniprot id: E1QRF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

572478:VDIS RS03420
gene id: 572478:VDIS_RS03420
uniprot id: E1QNB9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

572478:VDIS RS02845
gene id: 572478:VDIS_RS02845
uniprot id: E1QUX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572478:VDIS RS07670
gene id: 572478:VDIS_RS07670
uniprot id: E1QTF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572478:VDIS RS07870
gene id: 572478:VDIS_RS07870
uniprot id: E1QTR2
names: Subcellular Location Annotation
messages: Membrane

572478:VDIS RS01145
gene id: 572478:VDIS_RS01145
uniprot id: E1QT54
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.