555778:HNEAP RS00210
gene id: 555778:HNEAP_RS00210
uniprot id: D0KVY2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

555778:HNEAP RS10685
gene id: 555778:HNEAP_RS10685
uniprot id: D0KW57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

555778:HNEAP RS00750
gene id: 555778:HNEAP_RS00750
uniprot id: D0KWM3
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS10755
gene id: 555778:HNEAP_RS10755
uniprot id: D0KW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

555778:HNEAP RS03370
gene id: 555778:HNEAP_RS03370
uniprot id: D0KYJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05530
gene id: 555778:HNEAP_RS05530
uniprot id: D0KZR4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS00705
gene id: 555778:HNEAP_RS00705
uniprot id: D0KWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS05500
gene id: 555778:HNEAP_RS05500
uniprot id: D0KZQ7
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

555778:HNEAP RS08350
gene id: 555778:HNEAP_RS08350
uniprot id: D0L1C7
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

555778:HNEAP RS04615
gene id: 555778:HNEAP_RS04615
uniprot id: D0KZ83
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

555778:HNEAP RS00355
gene id: 555778:HNEAP_RS00355
uniprot id: D0KW12
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

555778:HNEAP RS02740
gene id: 555778:HNEAP_RS02740
uniprot id: D0KY73
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

555778:HNEAP RS03815
gene id: 555778:HNEAP_RS03815
uniprot id: D0KYT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

555778:HNEAP RS01095
gene id: 555778:HNEAP_RS01095
uniprot id: D0KX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

555778:HNEAP RS03215
gene id: 555778:HNEAP_RS03215
uniprot id: D0KYG5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS09405
gene id: 555778:HNEAP_RS09405
uniprot id: D0L1Z1
names: Similarity
messages: Belongs to the CFA/CMAS family.

555778:HNEAP RS02200
gene id: 555778:HNEAP_RS02200
uniprot id: D0KXX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

555778:HNEAP RS05135
gene id: 555778:HNEAP_RS05135
uniprot id: D0KZI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).

555778:HNEAP RS01855
gene id: 555778:HNEAP_RS01855
uniprot id: D0KXQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPS (TC 1.B.20) family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS11675
gene id: 555778:HNEAP_RS11675
uniprot id: D0KX33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

555778:HNEAP RS04020
gene id: 555778:HNEAP_RS04020
uniprot id: D0KYW9
names: Similarity
messages: Belongs to the creatininase superfamily.

555778:HNEAP RS12240
gene id: 555778:HNEAP_RS12240
uniprot id: D0KZS0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

555778:HNEAP RS06380
gene id: 555778:HNEAP_RS06380
uniprot id: D0L084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

555778:HNEAP RS04320
gene id: 555778:HNEAP_RS04320
uniprot id: D0KZ24
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS08235
gene id: 555778:HNEAP_RS08235
uniprot id: D0L1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

555778:HNEAP RS09330
gene id: 555778:HNEAP_RS09330
uniprot id: D0L1X6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

555778:HNEAP RS06095
gene id: 555778:HNEAP_RS06095
uniprot id: D0L024
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MerP family.
messages: Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.
messages: Monomer.
messages: Periplasm

555778:HNEAP RS06655
gene id: 555778:HNEAP_RS06655
uniprot id: D0L0D8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

555778:HNEAP RS05075
gene id: 555778:HNEAP_RS05075
uniprot id: D0KZH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

555778:HNEAP RS07775
gene id: 555778:HNEAP_RS07775
uniprot id: D0L109
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

555778:HNEAP RS00655
gene id: 555778:HNEAP_RS00655
uniprot id: D0KWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

555778:HNEAP RS02870
gene id: 555778:HNEAP_RS02870
uniprot id: D0KY97
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 104 family.
messages: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.

555778:HNEAP RS09875
gene id: 555778:HNEAP_RS09875
uniprot id: D0KVH6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS10065
gene id: 555778:HNEAP_RS10065
uniprot id: D0KVL4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

555778:HNEAP RS11020
gene id: 555778:HNEAP_RS11020
uniprot id: D0KWC3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.
messages: Belongs to the rubredoxin family.

555778:HNEAP RS07370
gene id: 555778:HNEAP_RS07370
uniprot id: D0L0T0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

555778:HNEAP RS04190
gene id: 555778:HNEAP_RS04190
uniprot id: D0KYZ9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

555778:HNEAP RS06830
gene id: 555778:HNEAP_RS06830
uniprot id: D0L0H4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

555778:HNEAP RS10980
gene id: 555778:HNEAP_RS10980
uniprot id: D0KWB5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

555778:HNEAP RS01560
gene id: 555778:HNEAP_RS01560
uniprot id: D0KXG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

555778:HNEAP RS06860
gene id: 555778:HNEAP_RS06860
uniprot id: D0L0I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

555778:HNEAP RS04560
gene id: 555778:HNEAP_RS04560
uniprot id: D0KZ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

555778:HNEAP RS04520
gene id: 555778:HNEAP_RS04520
uniprot id: D0KZ64
names: Similarity
messages: Belongs to the peptidase M24B family.

555778:HNEAP RS02555
gene id: 555778:HNEAP_RS02555
uniprot id: D0KY41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

555778:HNEAP RS02155
gene id: 555778:HNEAP_RS02155
uniprot id: D0KXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

555778:HNEAP RS11690
gene id: 555778:HNEAP_RS11690
uniprot id: D0KX36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

555778:HNEAP RS01760
gene id: 555778:HNEAP_RS01760
uniprot id: D0KXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

555778:HNEAP RS08405
gene id: 555778:HNEAP_RS08405
uniprot id: D0L1D8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05025
gene id: 555778:HNEAP_RS05025
uniprot id: D0KZG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

555778:HNEAP RS09695
gene id: 555778:HNEAP_RS09695
uniprot id: D0L248
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell inner membrane
messages: Cytoplasm

555778:HNEAP RS05785
gene id: 555778:HNEAP_RS05785
uniprot id: D0KZW2
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

555778:HNEAP RS06015
gene id: 555778:HNEAP_RS06015
uniprot id: D0L008
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

555778:HNEAP RS09365
gene id: 555778:HNEAP_RS09365
uniprot id: D0L1Y3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

555778:HNEAP RS12920
gene id: 555778:HNEAP_RS12920
uniprot id: D0KXC6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS07335
gene id: 555778:HNEAP_RS07335
uniprot id: D0L0S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

555778:HNEAP RS09670
gene id: 555778:HNEAP_RS09670
uniprot id: D0L243
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

555778:HNEAP RS07275
gene id: 555778:HNEAP_RS07275
uniprot id: D0L0R1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01850
gene id: 555778:HNEAP_RS01850
uniprot id: D0KXQ8
names: Subcellular Location Annotation
messages: Cytoplasm

555778:HNEAP RS10200
gene id: 555778:HNEAP_RS10200
uniprot id: D0KVN9
names: Similarity
messages: Belongs to the TrpC family.

555778:HNEAP RS09660
gene id: 555778:HNEAP_RS09660
uniprot id: D0L241
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

555778:HNEAP RS03430
gene id: 555778:HNEAP_RS03430
uniprot id: D0KYK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

555778:HNEAP RS08995
gene id: 555778:HNEAP_RS08995
uniprot id: D0L1Q8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

555778:HNEAP RS00035
gene id: 555778:HNEAP_RS00035
uniprot id: D0KVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

555778:HNEAP RS06870
gene id: 555778:HNEAP_RS06870
uniprot id: D0L0I2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

555778:HNEAP RS05360
gene id: 555778:HNEAP_RS05360
uniprot id: D0KZM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

555778:HNEAP RS06955
gene id: 555778:HNEAP_RS06955
uniprot id: D0L0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

555778:HNEAP RS01565
gene id: 555778:HNEAP_RS01565
uniprot id: D0KXG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

555778:HNEAP RS02570
gene id: 555778:HNEAP_RS02570
uniprot id: D0KY44
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

555778:HNEAP RS00155
gene id: 555778:HNEAP_RS00155
uniprot id: D0KVX0
names: Similarity
messages: Belongs to the BolA/IbaG family.

555778:HNEAP RS08310
gene id: 555778:HNEAP_RS08310
uniprot id: D0L1B9
names: Similarity
messages: Belongs to the TrbG/VirB9 family.

555778:HNEAP RS04800
gene id: 555778:HNEAP_RS04800
uniprot id: D0KZC1
names: Similarity
messages: Belongs to the FcoT family.

555778:HNEAP RS01485
gene id: 555778:HNEAP_RS01485
uniprot id: D0KXF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS10140
gene id: 555778:HNEAP_RS10140
uniprot id: D0KVM7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS00595
gene id: 555778:HNEAP_RS00595
uniprot id: D0KWJ2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

555778:HNEAP RS10165
gene id: 555778:HNEAP_RS10165
uniprot id: D0KVN2
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS09495
gene id: 555778:HNEAP_RS09495
uniprot id: D0L208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS00285
gene id: 555778:HNEAP_RS00285
uniprot id: D0KVZ7
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

555778:HNEAP RS07240
gene id: 555778:HNEAP_RS07240
uniprot id: D0L0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

555778:HNEAP RS11300
gene id: 555778:HNEAP_RS11300
uniprot id: D0KWW0
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

555778:HNEAP RS08920
gene id: 555778:HNEAP_RS08920
uniprot id: D0L1P3
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09295
gene id: 555778:HNEAP_RS09295
uniprot id: D0L1W9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

555778:HNEAP RS10855
gene id: 555778:HNEAP_RS10855
uniprot id: D0KW90
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01040
gene id: 555778:HNEAP_RS01040
uniprot id: D0KWS9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS08865
gene id: 555778:HNEAP_RS08865
uniprot id: D0L1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS07025
gene id: 555778:HNEAP_RS07025
uniprot id: D0L0L3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

555778:HNEAP RS06680
gene id: 555778:HNEAP_RS06680
uniprot id: D0L0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

555778:HNEAP RS08695
gene id: 555778:HNEAP_RS08695
uniprot id: D0L1J8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

555778:HNEAP RS08615
gene id: 555778:HNEAP_RS08615
uniprot id: D0L1I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

555778:HNEAP RS09380
gene id: 555778:HNEAP_RS09380
uniprot id: D0L1Y6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS02195
gene id: 555778:HNEAP_RS02195
uniprot id: D0KXX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

555778:HNEAP RS04940
gene id: 555778:HNEAP_RS04940
uniprot id: D0KZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

555778:HNEAP RS07160
gene id: 555778:HNEAP_RS07160
uniprot id: D0L0N9
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02760
gene id: 555778:HNEAP_RS02760
uniprot id: D0KY77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

555778:HNEAP RS05475
gene id: 555778:HNEAP_RS05475
uniprot id: D0KZQ2
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

555778:HNEAP RS01730
gene id: 555778:HNEAP_RS01730
uniprot id: D0KXN8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

555778:HNEAP RS10400
gene id: 555778:HNEAP_RS10400
uniprot id: D0KVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

555778:HNEAP RS07465
gene id: 555778:HNEAP_RS07465
uniprot id: D0L0U8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

555778:HNEAP RS02025
gene id: 555778:HNEAP_RS02025
uniprot id: D0KXU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

555778:HNEAP RS12085
gene id: 555778:HNEAP_RS12085
uniprot id: D0KWL3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Cleaved by prepilin peptidase.
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane
messages: Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.

555778:HNEAP RS05680
gene id: 555778:HNEAP_RS05680
uniprot id: D0KZU4
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

555778:HNEAP RS02210
gene id: 555778:HNEAP_RS02210
uniprot id: D0KXX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

555778:HNEAP RS05165
gene id: 555778:HNEAP_RS05165
uniprot id: D0KZJ0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS06480
gene id: 555778:HNEAP_RS06480
uniprot id: D0L0A4
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS03185
gene id: 555778:HNEAP_RS03185
uniprot id: D0KYF9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

555778:HNEAP RS07875
gene id: 555778:HNEAP_RS07875
uniprot id: D0L129
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

555778:HNEAP RS03095
gene id: 555778:HNEAP_RS03095
uniprot id: D0KYE3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

555778:HNEAP RS01680
gene id: 555778:HNEAP_RS01680
uniprot id: D0KXI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

555778:HNEAP RS03850
gene id: 555778:HNEAP_RS03850
uniprot id: D0KYT8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

555778:HNEAP RS01310
gene id: 555778:HNEAP_RS01310
uniprot id: D0KXB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

555778:HNEAP RS05445
gene id: 555778:HNEAP_RS05445
uniprot id: D0KZP6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

555778:HNEAP RS03540
gene id: 555778:HNEAP_RS03540
uniprot id: D0KYM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

555778:HNEAP RS05715
gene id: 555778:HNEAP_RS05715
uniprot id: D0KZV1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

555778:HNEAP RS07970
gene id: 555778:HNEAP_RS07970
uniprot id: D0L148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

555778:HNEAP RS02160
gene id: 555778:HNEAP_RS02160
uniprot id: D0KXW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

555778:HNEAP RS10765
gene id: 555778:HNEAP_RS10765
uniprot id: D0KW72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

555778:HNEAP RS06450
gene id: 555778:HNEAP_RS06450
uniprot id: D0L098
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

555778:HNEAP RS02275
gene id: 555778:HNEAP_RS02275
uniprot id: D0KXZ2
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

555778:HNEAP RS07295
gene id: 555778:HNEAP_RS07295
uniprot id: D0L0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS08365
gene id: 555778:HNEAP_RS08365
uniprot id: D0L1D0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

555778:HNEAP RS00290
gene id: 555778:HNEAP_RS00290
uniprot id: D0KVZ8
names: Similarity
messages: Belongs to the UPF0178 family.

555778:HNEAP RS03160
gene id: 555778:HNEAP_RS03160
uniprot id: D0KYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

555778:HNEAP RS10560
gene id: 555778:HNEAP_RS10560
uniprot id: D0KW36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

555778:HNEAP RS07430
gene id: 555778:HNEAP_RS07430
uniprot id: D0L0U1
names: Similarity
messages: Belongs to the cytochrome P450 family.

555778:HNEAP RS11605
gene id: 555778:HNEAP_RS11605
uniprot id: D0KX19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

555778:HNEAP RS07090
gene id: 555778:HNEAP_RS07090
uniprot id: D0L0M5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS04445
gene id: 555778:HNEAP_RS04445
uniprot id: D0KZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

555778:HNEAP RS07825
gene id: 555778:HNEAP_RS07825
uniprot id: D0L119
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10145
gene id: 555778:HNEAP_RS10145
uniprot id: D0KVM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

555778:HNEAP RS05295
gene id: 555778:HNEAP_RS05295
uniprot id: D0KZL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

555778:HNEAP RS07350
gene id: 555778:HNEAP_RS07350
uniprot id: D0L0S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

555778:HNEAP RS10405
gene id: 555778:HNEAP_RS10405
uniprot id: D0KVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

555778:HNEAP RS04185
gene id: 555778:HNEAP_RS04185
uniprot id: D0KYZ8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

555778:HNEAP RS11670
gene id: 555778:HNEAP_RS11670
uniprot id: D0KX32
names: Similarity
messages: Belongs to the GARS family.

555778:HNEAP RS07650
gene id: 555778:HNEAP_RS07650
uniprot id: D0L0Y5
names: Similarity
messages: Belongs to the CFA/CMAS family.

555778:HNEAP RS07085
gene id: 555778:HNEAP_RS07085
uniprot id: D0L0M4
names: Similarity
messages: Belongs to the MipA/OmpV family.

555778:HNEAP RS06695
gene id: 555778:HNEAP_RS06695
uniprot id: D0L0E6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

555778:HNEAP RS10740
gene id: 555778:HNEAP_RS10740
uniprot id: D0KW67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

555778:HNEAP RS00945
gene id: 555778:HNEAP_RS00945
uniprot id: D0KWR0
names: Function
names: Similarity
messages: Belongs to the acetyltransferase family. EctA subfamily.
messages: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.

555778:HNEAP RS13055
gene id: 555778:HNEAP_RS13055
uniprot id: D0L0X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

555778:HNEAP RS05095
gene id: 555778:HNEAP_RS05095
uniprot id: D0KZH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS07005
gene id: 555778:HNEAP_RS07005
uniprot id: D0L0K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

555778:HNEAP RS11225
gene id: 555778:HNEAP_RS11225
uniprot id: D0KWU6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

555778:HNEAP RS09135
gene id: 555778:HNEAP_RS09135
uniprot id: D0L1T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

555778:HNEAP RS03515
gene id: 555778:HNEAP_RS03515
uniprot id: D0KYM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

555778:HNEAP RS02800
gene id: 555778:HNEAP_RS02800
uniprot id: D0KY85
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

555778:HNEAP RS11685
gene id: 555778:HNEAP_RS11685
uniprot id: D0KX35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

555778:HNEAP RS03715
gene id: 555778:HNEAP_RS03715
uniprot id: D0KYR0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

555778:HNEAP RS11365
gene id: 555778:HNEAP_RS11365
uniprot id: D0KWX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

555778:HNEAP RS06900
gene id: 555778:HNEAP_RS06900
uniprot id: D0L0I8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

555778:HNEAP RS11240
gene id: 555778:HNEAP_RS11240
uniprot id: D0KWU9
names: Similarity
messages: Belongs to the ice-binding protein family.

555778:HNEAP RS09015
gene id: 555778:HNEAP_RS09015
uniprot id: D0L1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

555778:HNEAP RS06865
gene id: 555778:HNEAP_RS06865
uniprot id: D0L0I1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

555778:HNEAP RS09265
gene id: 555778:HNEAP_RS09265
uniprot id: D0L1W3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS07280
gene id: 555778:HNEAP_RS07280
uniprot id: D0L0R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

555778:HNEAP RS12395
gene id: 555778:HNEAP_RS12395
uniprot id: D0KWV0
names: Similarity
messages: Belongs to the transposase 8 family.

555778:HNEAP RS07195
gene id: 555778:HNEAP_RS07195
uniprot id: D0L0P7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

555778:HNEAP RS10725
gene id: 555778:HNEAP_RS10725
uniprot id: D0KW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

555778:HNEAP RS00225
gene id: 555778:HNEAP_RS00225
uniprot id: D0KVY5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

555778:HNEAP RS08610
gene id: 555778:HNEAP_RS08610
uniprot id: D0L1H8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02225
gene id: 555778:HNEAP_RS02225
uniprot id: D0KXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS10775
gene id: 555778:HNEAP_RS10775
uniprot id: D0KW74
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

555778:HNEAP RS04875
gene id: 555778:HNEAP_RS04875
uniprot id: D0KZD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

555778:HNEAP RS02905
gene id: 555778:HNEAP_RS02905
uniprot id: D0KYA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

555778:HNEAP RS07230
gene id: 555778:HNEAP_RS07230
uniprot id: D0L0Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

555778:HNEAP RS00545
gene id: 555778:HNEAP_RS00545
uniprot id: D0KWI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS03990
gene id: 555778:HNEAP_RS03990
uniprot id: D0KYW3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS01890
gene id: 555778:HNEAP_RS01890
uniprot id: D0KXR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS10950
gene id: 555778:HNEAP_RS10950
uniprot id: D0KWA9
names: Similarity
messages: Belongs to the YfgM family.

555778:HNEAP RS03455
gene id: 555778:HNEAP_RS03455
uniprot id: D0KYL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

555778:HNEAP RS04630
gene id: 555778:HNEAP_RS04630
uniprot id: P45688
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
messages: Carboxysome
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212, PubMed:30305640). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131).
messages: Homohexamer with a small central pore (PubMed:19690376). Interacts with the N-terminus (residues 1-136) of RuBisCO (CbbL) (PubMed:30305640).
messages: One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome (Probable). The shell probably limits the diffusion of CO(2) into and out of the carboxysome (Probable). There are estimated to be 2970 CsoS1A/CsoS1C proteins per carboxysome (the proteins differ by only 1 residue) (Ref.4).
messages: Required for growth in ambient air.
messages: The tight homohexamer forms a pore with an opening of about 2 Angstroms in diameter which is positively charged.
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS09895
gene id: 555778:HNEAP_RS09895
uniprot id: D0KVI0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

555778:HNEAP RS01460
gene id: 555778:HNEAP_RS01460
uniprot id: D0KXE8
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

555778:HNEAP RS08085
gene id: 555778:HNEAP_RS08085
uniprot id: D0L172
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

555778:HNEAP RS07220
gene id: 555778:HNEAP_RS07220
uniprot id: D0L0Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

555778:HNEAP RS01755
gene id: 555778:HNEAP_RS01755
uniprot id: D0KXP3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS04155
gene id: 555778:HNEAP_RS04155
uniprot id: D0KYZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

555778:HNEAP RS11935
gene id: 555778:HNEAP_RS11935
uniprot id: D0KXL6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10835
gene id: 555778:HNEAP_RS10835
uniprot id: D0KW86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

555778:HNEAP RS10970
gene id: 555778:HNEAP_RS10970
uniprot id: D0KWB3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS10370
gene id: 555778:HNEAP_RS10370
uniprot id: D0KVS2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

555778:HNEAP RS09060
gene id: 555778:HNEAP_RS09060
uniprot id: D0L1S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

555778:HNEAP RS05210
gene id: 555778:HNEAP_RS05210
uniprot id: D0KZJ9
names: Similarity
messages: Belongs to the MotB family.

555778:HNEAP RS03610
gene id: 555778:HNEAP_RS03610
uniprot id: D0KYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

555778:HNEAP RS00985
gene id: 555778:HNEAP_RS00985
uniprot id: D0KWR8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

555778:HNEAP RS03010
gene id: 555778:HNEAP_RS03010
uniprot id: D0KYC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

555778:HNEAP RS02470
gene id: 555778:HNEAP_RS02470
uniprot id: D0KY24
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10430
gene id: 555778:HNEAP_RS10430
uniprot id: D0KVT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

555778:HNEAP RS09030
gene id: 555778:HNEAP_RS09030
uniprot id: D0L1R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell inner membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

555778:HNEAP RS08175
gene id: 555778:HNEAP_RS08175
uniprot id: D0L191
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

555778:HNEAP RS04810
gene id: 555778:HNEAP_RS04810
uniprot id: D0KZC3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

555778:HNEAP RS11060
gene id: 555778:HNEAP_RS11060
uniprot id: D0KWD1
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

555778:HNEAP RS05490
gene id: 555778:HNEAP_RS05490
uniprot id: D0KZQ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS07375
gene id: 555778:HNEAP_RS07375
uniprot id: D0L0T1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

555778:HNEAP RS06945
gene id: 555778:HNEAP_RS06945
uniprot id: D0L0J7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

555778:HNEAP RS06940
gene id: 555778:HNEAP_RS06940
uniprot id: D0L0J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

555778:HNEAP RS02215
gene id: 555778:HNEAP_RS02215
uniprot id: D0KXX9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01630
gene id: 555778:HNEAP_RS01630
uniprot id: D0KXH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

555778:HNEAP RS02665
gene id: 555778:HNEAP_RS02665
uniprot id: D0KY64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

555778:HNEAP RS03270
gene id: 555778:HNEAP_RS03270
uniprot id: D0KYH6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06620
gene id: 555778:HNEAP_RS06620
uniprot id: D0L0D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

555778:HNEAP RS00020
gene id: 555778:HNEAP_RS00020
uniprot id: D0KVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

555778:HNEAP RS06615
gene id: 555778:HNEAP_RS06615
uniprot id: D0L0D0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

555778:HNEAP RS06210
gene id: 555778:HNEAP_RS06210
uniprot id: D0L049
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

555778:HNEAP RS02240
gene id: 555778:HNEAP_RS02240
uniprot id: D0KXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

555778:HNEAP RS02855
gene id: 555778:HNEAP_RS02855
uniprot id: D0KY94
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

555778:HNEAP RS01550
gene id: 555778:HNEAP_RS01550
uniprot id: D0KXG1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

555778:HNEAP RS03985
gene id: 555778:HNEAP_RS03985
uniprot id: D0KYW2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

555778:HNEAP RS10375
gene id: 555778:HNEAP_RS10375
uniprot id: D0KVS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

555778:HNEAP RS06350
gene id: 555778:HNEAP_RS06350
uniprot id: D0L078
names: Similarity
messages: Belongs to the UPF0250 family.

555778:HNEAP RS08705
gene id: 555778:HNEAP_RS08705
uniprot id: D0L1K0
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS00975
gene id: 555778:HNEAP_RS00975
uniprot id: D0KWR6
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

555778:HNEAP RS00260
gene id: 555778:HNEAP_RS00260
uniprot id: D0KVZ2
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

555778:HNEAP RS11845
gene id: 555778:HNEAP_RS11845
uniprot id: D0KXJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

555778:HNEAP RS10895
gene id: 555778:HNEAP_RS10895
uniprot id: D0KW98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

555778:HNEAP RS01490
gene id: 555778:HNEAP_RS01490
uniprot id: D0KXF4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

555778:HNEAP RS04365
gene id: 555778:HNEAP_RS04365
uniprot id: D0KZ33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

555778:HNEAP RS09090
gene id: 555778:HNEAP_RS09090
uniprot id: D0L1S6
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

555778:HNEAP RS02885
gene id: 555778:HNEAP_RS02885
uniprot id: D0KYA0
names: Similarity
messages: Belongs to the UPF0235 family.

555778:HNEAP RS10885
gene id: 555778:HNEAP_RS10885
uniprot id: D0KW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS10125
gene id: 555778:HNEAP_RS10125
uniprot id: D0KVM4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

555778:HNEAP RS00045
gene id: 555778:HNEAP_RS00045
uniprot id: D0KVU6
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

555778:HNEAP RS05900
gene id: 555778:HNEAP_RS05900
uniprot id: D0KZY4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

555778:HNEAP RS08370
gene id: 555778:HNEAP_RS08370
uniprot id: D0L1D1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

555778:HNEAP RS02440
gene id: 555778:HNEAP_RS02440
uniprot id: D0KY18
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS01650
gene id: 555778:HNEAP_RS01650
uniprot id: D0KXI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

555778:HNEAP RS09790
gene id: 555778:HNEAP_RS09790
uniprot id: D0KVF9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

555778:HNEAP RS05925
gene id: 555778:HNEAP_RS05925
uniprot id: D0KZZ0
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS10910
gene id: 555778:HNEAP_RS10910
uniprot id: D0KWA1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

555778:HNEAP RS01775
gene id: 555778:HNEAP_RS01775
uniprot id: D0KXP8
names: Similarity
messages: Belongs to the aspartokinase family.

555778:HNEAP RS01020
gene id: 555778:HNEAP_RS01020
uniprot id: D0KWS5
names: Similarity
messages: Belongs to the glutamine synthetase family.

555778:HNEAP RS00775
gene id: 555778:HNEAP_RS00775
uniprot id: D0KWM8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

555778:HNEAP RS08850
gene id: 555778:HNEAP_RS08850
uniprot id: D0L1M8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

555778:HNEAP RS11745
gene id: 555778:HNEAP_RS11745
uniprot id: D0KX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS05655
gene id: 555778:HNEAP_RS05655
uniprot id: D0KZT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS11815
gene id: 555778:HNEAP_RS11815
uniprot id: D0KX59
names: Similarity
messages: Belongs to the glutamine synthetase family.

555778:HNEAP RS06220
gene id: 555778:HNEAP_RS06220
uniprot id: D0L051
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS08915
gene id: 555778:HNEAP_RS08915
uniprot id: D0L1P2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS07545
gene id: 555778:HNEAP_RS07545
uniprot id: D0L0W3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

555778:HNEAP RS11830
gene id: 555778:HNEAP_RS11830
uniprot id: D0KX62
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

555778:HNEAP RS06600
gene id: 555778:HNEAP_RS06600
uniprot id: D0L0C7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

555778:HNEAP RS05720
gene id: 555778:HNEAP_RS05720
uniprot id: D0KZV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

555778:HNEAP RS02115
gene id: 555778:HNEAP_RS02115
uniprot id: D0KXV9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

555778:HNEAP RS04315
gene id: 555778:HNEAP_RS04315
uniprot id: D0KZ23
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS05245
gene id: 555778:HNEAP_RS05245
uniprot id: D0KZK6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

555778:HNEAP RS00140
gene id: 555778:HNEAP_RS00140
uniprot id: D0KVW7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

555778:HNEAP RS04780
gene id: 555778:HNEAP_RS04780
uniprot id: D0KZB9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

555778:HNEAP RS04535
gene id: 555778:HNEAP_RS04535
uniprot id: D0KZ67
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

555778:HNEAP RS08880
gene id: 555778:HNEAP_RS08880
uniprot id: D0L1N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS08380
gene id: 555778:HNEAP_RS08380
uniprot id: D0L1D3
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

555778:HNEAP RS11945
gene id: 555778:HNEAP_RS11945
uniprot id: D0KXL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

555778:HNEAP RS11770
gene id: 555778:HNEAP_RS11770
uniprot id: D0KX50
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

555778:HNEAP RS04545
gene id: 555778:HNEAP_RS04545
uniprot id: D0KZ69
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

555778:HNEAP RS08900
gene id: 555778:HNEAP_RS08900
uniprot id: D0L1N9
names: Similarity
messages: Belongs to the FrhG family.

555778:HNEAP RS00030
gene id: 555778:HNEAP_RS00030
uniprot id: D0KVU3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

555778:HNEAP RS09200
gene id: 555778:HNEAP_RS09200
uniprot id: D0L1V0
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.

555778:HNEAP RS03920
gene id: 555778:HNEAP_RS03920
uniprot id: D0KYV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

555778:HNEAP RS10090
gene id: 555778:HNEAP_RS10090
uniprot id: D0KVL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

555778:HNEAP RS02490
gene id: 555778:HNEAP_RS02490
uniprot id: D0KY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

555778:HNEAP RS03545
gene id: 555778:HNEAP_RS03545
uniprot id: D0KYM9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

555778:HNEAP RS09950
gene id: 555778:HNEAP_RS09950
uniprot id: D0KVJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

555778:HNEAP RS04655
gene id: 555778:HNEAP_RS04655
uniprot id: P45686
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ccbL-ccbS deletion does not grow in air, grows well with 5% CO(2), a high-CO(2) requiring phenotype (hcr) and forms empty but otherwise normal appearing carboxysomes. Required for growth in ambient air (PubMed:31406332).
messages: Belongs to the RuBisCO small chain family.
messages: Carboxysome
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212, PubMed:30305640). Alpha-carboxysomes are assembled in the complete absence of this enzyme in this bacteria, suggesting carboxysome-based microcompartments can be designed for applications such as custom chemical reactors or delivery vehicles (PubMed:18974784, PubMed:30305640).
messages: Heterohexadecamer of 8 large and 8 small subunits (PubMed:32123388). Interacts with CsoS2 (PubMed:30305640). Forms a CsoS2-CsoS1-RuBisCO complex (Probable). Holo-RuBisCO interacts with the N-terminal repeats of CsoS2; binding is sensitive to ionic strength. A fusion of a single N-terminal repeat to the C-terminus of the large subunit of RuBisCO (cbbL) shows the repeat can lie between a CbbL dimer, making minor contacts to CbbS; thus each RuBisCO holoenzyme could bind 8 repeats (PubMed:32123388).
messages: Produced when grown in air or in air supplemented with 5% CO(2). Part of the ccbL-ccbS operon.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (Ref.3, PubMed:18258595, PubMed:18974784). There are estimated to be 270 RuBisCO heterohexadecamers per carboxysome (Ref.6).
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

555778:HNEAP RS02975
gene id: 555778:HNEAP_RS02975
uniprot id: D0KYB8
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

555778:HNEAP RS04950
gene id: 555778:HNEAP_RS04950
uniprot id: D0KZF0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS01920
gene id: 555778:HNEAP_RS01920
uniprot id: D0KXR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

555778:HNEAP RS01745
gene id: 555778:HNEAP_RS01745
uniprot id: D0KXP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

555778:HNEAP RS08305
gene id: 555778:HNEAP_RS08305
uniprot id: D0L1B8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS06845
gene id: 555778:HNEAP_RS06845
uniprot id: D0L0H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS08670
gene id: 555778:HNEAP_RS08670
uniprot id: D0L1J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

555778:HNEAP RS10415
gene id: 555778:HNEAP_RS10415
uniprot id: D0KVT2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

555778:HNEAP RS03130
gene id: 555778:HNEAP_RS03130
uniprot id: D0KYE8
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

555778:HNEAP RS02670
gene id: 555778:HNEAP_RS02670
uniprot id: D0KY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

555778:HNEAP RS06675
gene id: 555778:HNEAP_RS06675
uniprot id: D0L0E2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

555778:HNEAP RS05645
gene id: 555778:HNEAP_RS05645
uniprot id: D0KZT7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

555778:HNEAP RS11495
gene id: 555778:HNEAP_RS11495
uniprot id: D0KWZ7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS03650
gene id: 555778:HNEAP_RS03650
uniprot id: D0KYP7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

555778:HNEAP RS02220
gene id: 555778:HNEAP_RS02220
uniprot id: D0KXY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

555778:HNEAP RS07065
gene id: 555778:HNEAP_RS07065
uniprot id: D0L0M0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

555778:HNEAP RS09715
gene id: 555778:HNEAP_RS09715
uniprot id: D0L252
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS03225
gene id: 555778:HNEAP_RS03225
uniprot id: D0KYG7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS03870
gene id: 555778:HNEAP_RS03870
uniprot id: D0KYU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

555778:HNEAP RS00780
gene id: 555778:HNEAP_RS00780
uniprot id: D0KWM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

555778:HNEAP RS02235
gene id: 555778:HNEAP_RS02235
uniprot id: D0KXY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that is essential for cell division.

555778:HNEAP RS10005
gene id: 555778:HNEAP_RS10005
uniprot id: D0KVK2
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

555778:HNEAP RS04375
gene id: 555778:HNEAP_RS04375
uniprot id: D0KZ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS10995
gene id: 555778:HNEAP_RS10995
uniprot id: D0KWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

555778:HNEAP RS05205
gene id: 555778:HNEAP_RS05205
uniprot id: D0KZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

555778:HNEAP RS05175
gene id: 555778:HNEAP_RS05175
uniprot id: D0KZJ2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

555778:HNEAP RS01000
gene id: 555778:HNEAP_RS01000
uniprot id: D0KWS1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS06365
gene id: 555778:HNEAP_RS06365
uniprot id: D0L081
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

555778:HNEAP RS04480
gene id: 555778:HNEAP_RS04480
uniprot id: D0KZ56
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

555778:HNEAP RS05450
gene id: 555778:HNEAP_RS05450
uniprot id: D0KZP7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

555778:HNEAP RS07550
gene id: 555778:HNEAP_RS07550
uniprot id: D0L0W4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

555778:HNEAP RS07925
gene id: 555778:HNEAP_RS07925
uniprot id: D0L139
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

555778:HNEAP RS11950
gene id: 555778:HNEAP_RS11950
uniprot id: D0KXL9
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS04665
gene id: 555778:HNEAP_RS04665
uniprot id: D0KZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

555778:HNEAP RS09730
gene id: 555778:HNEAP_RS09730
uniprot id: D0L255
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS06240
gene id: 555778:HNEAP_RS06240
uniprot id: D0L055
names: Similarity
messages: Belongs to the phosphorylase b kinase regulatory chain family.

555778:HNEAP RS10945
gene id: 555778:HNEAP_RS10945
uniprot id: D0KWA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS11920
gene id: 555778:HNEAP_RS11920
uniprot id: D0KXL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

555778:HNEAP RS12060
gene id: 555778:HNEAP_RS12060
uniprot id: D0KWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

555778:HNEAP RS03765
gene id: 555778:HNEAP_RS03765
uniprot id: D0KYS0
names: Subcellular Location Annotation
messages: Cytoplasm

555778:HNEAP RS09605
gene id: 555778:HNEAP_RS09605
uniprot id: D0L230
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

555778:HNEAP RS04075
gene id: 555778:HNEAP_RS04075
uniprot id: D0KYX8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS00995
gene id: 555778:HNEAP_RS00995
uniprot id: D0KWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

555778:HNEAP RS06595
gene id: 555778:HNEAP_RS06595
uniprot id: D0L0C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

555778:HNEAP RS03800
gene id: 555778:HNEAP_RS03800
uniprot id: D0KYS8
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

555778:HNEAP RS05675
gene id: 555778:HNEAP_RS05675
uniprot id: D0KZU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

555778:HNEAP RS04645
gene id: 555778:HNEAP_RS04645
uniprot id: O85042
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-class carbonic anhydrase family. CsoSCA subfamily.
messages: Carbonic anhydrase activity is inhibited by ethoxyzolamide, dithiothreitol, cyanide, and divalent metal chelators dipicolinic acid and nitrilotriacetic acid.
messages: Carboxysome
messages: Cells do not grow in normal air but do grow on 5% CO(2), called a high-CO(2) requiring phenotype, hcr. Loss of CA activity, requires 3.5 X more inorganic carbon for half-maximal CO(2) fixation. Carboxysomes are approximately normal except that ratio of CsoS2A:CsoS2B shifts from 1:1 to 2:1. Required for growth in ambient air (PubMed:31406332).
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131).
messages: Homodimer, may form filaments.
messages: Reversible hydration of carbon dioxide (PubMed:14729686, PubMed:17012396, PubMed:18258595). Essential for chemolithotrophic carbon dioxide fixation, supplies CO(2) to RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) in the carboxysome (Probable) (PubMed:18258595). There are estimated to be 40 CsoSCA dimers per carboxysome (Ref.5).
messages: The N-terminal domain is physically isolated from the rest of the protein and may serve to anchor the protein to the carboxysome shell or to RuBisCO; in PDB:2FGY the N-terminal domain binds Zn(2+) which is thought to be non-physiological. The central domain bears the catalytic Zn(2+), while the C-terminal domain is structurally similar to the central catalytic domain but cannot bind Zn(2+).
messages: The fourth ligand is a water molecule. Binds 1 Zn(2+) per monomer, in PDB:2FGY a second Zn(2+) is seen, but one of its ligands is an accidentally introduced mutation.
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS02265
gene id: 555778:HNEAP_RS02265
uniprot id: D0KXY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

555778:HNEAP RS05825
gene id: 555778:HNEAP_RS05825
uniprot id: D0KZX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

555778:HNEAP RS05310
gene id: 555778:HNEAP_RS05310
uniprot id: D0KZL9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

555778:HNEAP RS04515
gene id: 555778:HNEAP_RS04515
uniprot id: D0KZ63
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

555778:HNEAP RS03745
gene id: 555778:HNEAP_RS03745
uniprot id: D0KYR6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

555778:HNEAP RS09725
gene id: 555778:HNEAP_RS09725
uniprot id: D0L254
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS12270
gene id: 555778:HNEAP_RS12270
uniprot id: D0L0Z8
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

555778:HNEAP RS06930
gene id: 555778:HNEAP_RS06930
uniprot id: D0L0J4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

555778:HNEAP RS09300
gene id: 555778:HNEAP_RS09300
uniprot id: D0L1X0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06100
gene id: 555778:HNEAP_RS06100
uniprot id: D0L025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS07460
gene id: 555778:HNEAP_RS07460
uniprot id: D0L0U7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

555778:HNEAP RS05810
gene id: 555778:HNEAP_RS05810
uniprot id: D0KZW7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05765
gene id: 555778:HNEAP_RS05765
uniprot id: D0KZV8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02865
gene id: 555778:HNEAP_RS02865
uniprot id: D0KY96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS11120
gene id: 555778:HNEAP_RS11120
uniprot id: D0KWE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

555778:HNEAP RS07405
gene id: 555778:HNEAP_RS07405
uniprot id: D0L0T7
names: Similarity
messages: Belongs to the peptidase M16 family.

555778:HNEAP RS11900
gene id: 555778:HNEAP_RS11900
uniprot id: D0KXK9
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

555778:HNEAP RS03165
gene id: 555778:HNEAP_RS03165
uniprot id: D0KYF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

555778:HNEAP RS01260
gene id: 555778:HNEAP_RS01260
uniprot id: D0KXA9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

555778:HNEAP RS09905
gene id: 555778:HNEAP_RS09905
uniprot id: D0KVI2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10905
gene id: 555778:HNEAP_RS10905
uniprot id: D0KWA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS07215
gene id: 555778:HNEAP_RS07215
uniprot id: D0L0Q0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

555778:HNEAP RS11750
gene id: 555778:HNEAP_RS11750
uniprot id: D0KX46
names: Similarity
messages: Belongs to the P(II) protein family.

555778:HNEAP RS02935
gene id: 555778:HNEAP_RS02935
uniprot id: D0KYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Periplasm

555778:HNEAP RS07915
gene id: 555778:HNEAP_RS07915
uniprot id: D0L137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS08630
gene id: 555778:HNEAP_RS08630
uniprot id: D0L1I3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

555778:HNEAP RS03520
gene id: 555778:HNEAP_RS03520
uniprot id: D0KYM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

555778:HNEAP RS07815
gene id: 555778:HNEAP_RS07815
uniprot id: D0L117
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01025
gene id: 555778:HNEAP_RS01025
uniprot id: D0KWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

555778:HNEAP RS02020
gene id: 555778:HNEAP_RS02020
uniprot id: D0KXU0
names: Similarity
messages: Belongs to the pyruvate kinase family.

555778:HNEAP RS11610
gene id: 555778:HNEAP_RS11610
uniprot id: D0KX20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

555778:HNEAP RS10920
gene id: 555778:HNEAP_RS10920
uniprot id: D0KWA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

555778:HNEAP RS05910
gene id: 555778:HNEAP_RS05910
uniprot id: D0KZY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS02150
gene id: 555778:HNEAP_RS02150
uniprot id: D0KXW6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

555778:HNEAP RS09855
gene id: 555778:HNEAP_RS09855
uniprot id: D0KVH2
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

555778:HNEAP RS00590
gene id: 555778:HNEAP_RS00590
uniprot id: D0KWJ1
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

555778:HNEAP RS07655
gene id: 555778:HNEAP_RS07655
uniprot id: D0L0Y6
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

555778:HNEAP RS05690
gene id: 555778:HNEAP_RS05690
uniprot id: D0KZU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

555778:HNEAP RS04945
gene id: 555778:HNEAP_RS04945
uniprot id: D0KZE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

555778:HNEAP RS09560
gene id: 555778:HNEAP_RS09560
uniprot id: D0L221
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

555778:HNEAP RS01390
gene id: 555778:HNEAP_RS01390
uniprot id: D0KXD5
names: Similarity
messages: Belongs to the RelE toxin family.

555778:HNEAP RS08505
gene id: 555778:HNEAP_RS08505
uniprot id: D0L1F8
names: Similarity
messages: Belongs to the UPF0045 family.

555778:HNEAP RS08355
gene id: 555778:HNEAP_RS08355
uniprot id: D0L1C8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS03525
gene id: 555778:HNEAP_RS03525
uniprot id: D0KYM5
names: Subcellular Location Annotation
messages: Nucleus

555778:HNEAP RS09845
gene id: 555778:HNEAP_RS09845
uniprot id: D0KVH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

555778:HNEAP RS09410
gene id: 555778:HNEAP_RS09410
uniprot id: D0L1Z2
names: Similarity
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.

555778:HNEAP RS02030
gene id: 555778:HNEAP_RS02030
uniprot id: D0KXU2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

555778:HNEAP RS00530
gene id: 555778:HNEAP_RS00530
uniprot id: D0KWH9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

555778:HNEAP RS01275
gene id: 555778:HNEAP_RS01275
uniprot id: D0KXB2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05410
gene id: 555778:HNEAP_RS05410
uniprot id: D0KZN9
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

555778:HNEAP RS11665
gene id: 555778:HNEAP_RS11665
uniprot id: D0KX31
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06165
gene id: 555778:HNEAP_RS06165
uniprot id: D0L039
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

555778:HNEAP RS01740
gene id: 555778:HNEAP_RS01740
uniprot id: D0KXP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

555778:HNEAP RS05090
gene id: 555778:HNEAP_RS05090
uniprot id: D0KZH5
names: Similarity
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.

555778:HNEAP RS11735
gene id: 555778:HNEAP_RS11735
uniprot id: D0KX42
names: Similarity
messages: Belongs to the peptidase S41A family.

555778:HNEAP RS08060
gene id: 555778:HNEAP_RS08060
uniprot id: D0L167
names: Similarity
messages: Belongs to the type IA topoisomerase family.

555778:HNEAP RS03645
gene id: 555778:HNEAP_RS03645
uniprot id: D0KYP6
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

555778:HNEAP RS08815
gene id: 555778:HNEAP_RS08815
uniprot id: D0L1M1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

555778:HNEAP RS09965
gene id: 555778:HNEAP_RS09965
uniprot id: D0KVJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

555778:HNEAP RS09995
gene id: 555778:HNEAP_RS09995
uniprot id: D0KVK0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

555778:HNEAP RS11895
gene id: 555778:HNEAP_RS11895
uniprot id: D0KXK8
names: Similarity
messages: Belongs to the RutC family.

555778:HNEAP RS06385
gene id: 555778:HNEAP_RS06385
uniprot id: D0L085
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

555778:HNEAP RS05510
gene id: 555778:HNEAP_RS05510
uniprot id: D0KZQ9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS10880
gene id: 555778:HNEAP_RS10880
uniprot id: D0KW95
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

555778:HNEAP RS08300
gene id: 555778:HNEAP_RS08300
uniprot id: D0L1B7
names: Similarity
messages: Belongs to the darcynin family.

555778:HNEAP RS12355
gene id: 555778:HNEAP_RS12355
uniprot id: D0KVG5
names: Similarity
messages: Belongs to the SCO1/2 family.

555778:HNEAP RS05670
gene id: 555778:HNEAP_RS05670
uniprot id: D0KZU2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02035
gene id: 555778:HNEAP_RS02035
uniprot id: D0KXU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

555778:HNEAP RS05040
gene id: 555778:HNEAP_RS05040
uniprot id: D0KZG4
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09960
gene id: 555778:HNEAP_RS09960
uniprot id: D0KVJ3
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

555778:HNEAP RS09850
gene id: 555778:HNEAP_RS09850
uniprot id: D0KVH1
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09140
gene id: 555778:HNEAP_RS09140
uniprot id: D0L1T7
names: Similarity
messages: Belongs to the YggT family.

555778:HNEAP RS01210
gene id: 555778:HNEAP_RS01210
uniprot id: D0KX99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

555778:HNEAP RS07715
gene id: 555778:HNEAP_RS07715
uniprot id: D0L0Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

555778:HNEAP RS04930
gene id: 555778:HNEAP_RS04930
uniprot id: D0KZE6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

555778:HNEAP RS01105
gene id: 555778:HNEAP_RS01105
uniprot id: D0KX75
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

555778:HNEAP RS07820
gene id: 555778:HNEAP_RS07820
uniprot id: D0L118
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

555778:HNEAP RS08400
gene id: 555778:HNEAP_RS08400
uniprot id: D0L1D7
names: Similarity
messages: Belongs to the MotB family.

555778:HNEAP RS03640
gene id: 555778:HNEAP_RS03640
uniprot id: D0KYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

555778:HNEAP RS09935
gene id: 555778:HNEAP_RS09935
uniprot id: D0KVI8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

555778:HNEAP RS04920
gene id: 555778:HNEAP_RS04920
uniprot id: D0KZE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

555778:HNEAP RS05330
gene id: 555778:HNEAP_RS05330
uniprot id: D0KZM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

555778:HNEAP RS01895
gene id: 555778:HNEAP_RS01895
uniprot id: D0KXR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS07830
gene id: 555778:HNEAP_RS07830
uniprot id: D0L120
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

555778:HNEAP RS08605
gene id: 555778:HNEAP_RS08605
uniprot id: D0L1H7
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

555778:HNEAP RS00570
gene id: 555778:HNEAP_RS00570
uniprot id: D0KWI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

555778:HNEAP RS08730
gene id: 555778:HNEAP_RS08730
uniprot id: D0L1K5
names: Similarity
messages: Belongs to the thioredoxin family.

555778:HNEAP RS10675
gene id: 555778:HNEAP_RS10675
uniprot id: D0KW55
names: Similarity
messages: Belongs to the citrate synthase family.

555778:HNEAP RS00770
gene id: 555778:HNEAP_RS00770
uniprot id: D0KWM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

555778:HNEAP RS11505
gene id: 555778:HNEAP_RS11505
uniprot id: D0KWZ9
names: Similarity
messages: Belongs to the GSP E family.

555778:HNEAP RS05710
gene id: 555778:HNEAP_RS05710
uniprot id: D0KZV0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

555778:HNEAP RS02250
gene id: 555778:HNEAP_RS02250
uniprot id: D0KXY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

555778:HNEAP RS00540
gene id: 555778:HNEAP_RS00540
uniprot id: D0KWI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

555778:HNEAP RS06610
gene id: 555778:HNEAP_RS06610
uniprot id: D0L0C9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

555778:HNEAP RS07075
gene id: 555778:HNEAP_RS07075
uniprot id: D0L0M2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

555778:HNEAP RS11235
gene id: 555778:HNEAP_RS11235
uniprot id: D0KWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS03030
gene id: 555778:HNEAP_RS03030
uniprot id: D0KYC8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

555778:HNEAP RS04390
gene id: 555778:HNEAP_RS04390
uniprot id: D0KZ39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

555778:HNEAP RS10700
gene id: 555778:HNEAP_RS10700
uniprot id: D0KW60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

555778:HNEAP RS08620
gene id: 555778:HNEAP_RS08620
uniprot id: D0L1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

555778:HNEAP RS07310
gene id: 555778:HNEAP_RS07310
uniprot id: D0L0R8
names: Similarity
messages: Belongs to the YciI family.

555778:HNEAP RS09075
gene id: 555778:HNEAP_RS09075
uniprot id: D0L1S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

555778:HNEAP RS09565
gene id: 555778:HNEAP_RS09565
uniprot id: D0L222
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

555778:HNEAP RS08985
gene id: 555778:HNEAP_RS08985
uniprot id: D0L1Q6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

555778:HNEAP RS05695
gene id: 555778:HNEAP_RS05695
uniprot id: D0KZU7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

555778:HNEAP RS09750
gene id: 555778:HNEAP_RS09750
uniprot id: D0L259
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

555778:HNEAP RS07680
gene id: 555778:HNEAP_RS07680
uniprot id: D0L0Z0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

555778:HNEAP RS06835
gene id: 555778:HNEAP_RS06835
uniprot id: D0L0H5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

555778:HNEAP RS04640
gene id: 555778:HNEAP_RS04640
uniprot id: O85043
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double csoS4a-csoS4B disruption does not grow in ambient air, has a wild-type growth rate in 5% CO(2), called a high-CO(2) requiring phenotype, hcr. It does not grow to the same cell density as wild-type. 1/3 fewer carboxysomes are seen per cell, about 13% of which are elongated. The carboxysome shell is more permeable than usual to inorganic carbon. Required for growth in ambient air (PubMed:31406332).
messages: Belongs to the CcmL/EutN family. CsoS4 subfamily.
messages: Carboxysome
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131).
messages: Homopentamer.
messages: Probably forms vertices in the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered. Has been modeled to induce curvature upon insertion into an otherwise flat hexagonal layer of major carboxysome subunits (Probable). A minor shell protein, only 12 pentamers of CsoS4A/CsoS4B are calculated to be present in each carboxysome. The 2 CsoS4 proteins contribute to the impermeability of the carboxysome to CO(2) (PubMed:19844578).
messages: The tight homopentamer forms a pore with an opening of about 3.5 Angstroms in diameter which is positively charged (PubMed:18292340). A short loop (residues 30-33) protrudes above the center of the concave face to different degrees (Probable).
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS03355
gene id: 555778:HNEAP_RS03355
uniprot id: D0KYJ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

555778:HNEAP RS03915
gene id: 555778:HNEAP_RS03915
uniprot id: D0KYV0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

555778:HNEAP RS10850
gene id: 555778:HNEAP_RS10850
uniprot id: D0KW89
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

555778:HNEAP RS10805
gene id: 555778:HNEAP_RS10805
uniprot id: D0KW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

555778:HNEAP RS04965
gene id: 555778:HNEAP_RS04965
uniprot id: D0KZF3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS07745
gene id: 555778:HNEAP_RS07745
uniprot id: D0L103
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

555778:HNEAP RS11580
gene id: 555778:HNEAP_RS11580
uniprot id: D0KX14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

555778:HNEAP RS04550
gene id: 555778:HNEAP_RS04550
uniprot id: D0KZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS00295
gene id: 555778:HNEAP_RS00295
uniprot id: D0KVZ9
names: Similarity
messages: Belongs to the skp family.

555778:HNEAP RS04150
gene id: 555778:HNEAP_RS04150
uniprot id: D0KYZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

555778:HNEAP RS11645
gene id: 555778:HNEAP_RS11645
uniprot id: D0KX27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

555778:HNEAP RS01620
gene id: 555778:HNEAP_RS01620
uniprot id: D0KXH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

555778:HNEAP RS06105
gene id: 555778:HNEAP_RS06105
uniprot id: D0L026
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

555778:HNEAP RS01590
gene id: 555778:HNEAP_RS01590
uniprot id: D0KXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

555778:HNEAP RS00555
gene id: 555778:HNEAP_RS00555
uniprot id: D0KWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

555778:HNEAP RS09940
gene id: 555778:HNEAP_RS09940
uniprot id: D0KVI9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

555778:HNEAP RS09630
gene id: 555778:HNEAP_RS09630
uniprot id: D0L235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

555778:HNEAP RS00360
gene id: 555778:HNEAP_RS00360
uniprot id: D0KW13
names: Similarity
messages: Belongs to the YoeB family.

555778:HNEAP RS09975
gene id: 555778:HNEAP_RS09975
uniprot id: D0KVJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

555778:HNEAP RS11960
gene id: 555778:HNEAP_RS11960
uniprot id: D0KXM1
names: Similarity
messages: Belongs to the SCO1/2 family.

555778:HNEAP RS09570
gene id: 555778:HNEAP_RS09570
uniprot id: D0L223
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

555778:HNEAP RS07570
gene id: 555778:HNEAP_RS07570
uniprot id: D0L0W8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

555778:HNEAP RS05505
gene id: 555778:HNEAP_RS05505
uniprot id: Q9ZHZ4
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type II subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Form II RuBisCO is expressed in the presence of form I, when grown in air with or without 5% CO(2), although it is not the major activity. When the form I gene is disrupted the RuBisCO form II activity increases, but is not found in carboxysomes (at protein level).
messages: Homodimer.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits.

555778:HNEAP RS07380
gene id: 555778:HNEAP_RS07380
uniprot id: D0L0T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

555778:HNEAP RS03895
gene id: 555778:HNEAP_RS03895
uniprot id: D0KYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

555778:HNEAP RS04510
gene id: 555778:HNEAP_RS04510
uniprot id: D0KZ62
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

555778:HNEAP RS11940
gene id: 555778:HNEAP_RS11940
uniprot id: D0KXL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
messages: Monomer.

555778:HNEAP RS06185
gene id: 555778:HNEAP_RS06185
uniprot id: D0L043
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

555778:HNEAP RS02565
gene id: 555778:HNEAP_RS02565
uniprot id: D0KY43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

555778:HNEAP RS01545
gene id: 555778:HNEAP_RS01545
uniprot id: D0KXG0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

555778:HNEAP RS08510
gene id: 555778:HNEAP_RS08510
uniprot id: D0L1F9
names: Similarity
messages: Belongs to the peptidase S8 family.

555778:HNEAP RS07520
gene id: 555778:HNEAP_RS07520
uniprot id: D0L0V8
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

555778:HNEAP RS05640
gene id: 555778:HNEAP_RS05640
uniprot id: D0KZT6
names: PTM
messages: Binds 1 heme group per subunit.

555778:HNEAP RS10940
gene id: 555778:HNEAP_RS10940
uniprot id: D0KWA7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

555778:HNEAP RS00870
gene id: 555778:HNEAP_RS00870
uniprot id: D0KWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

555778:HNEAP RS07565
gene id: 555778:HNEAP_RS07565
uniprot id: D0L0W7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

555778:HNEAP RS09225
gene id: 555778:HNEAP_RS09225
uniprot id: D0L1V5
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

555778:HNEAP RS07390
gene id: 555778:HNEAP_RS07390
uniprot id: D0L0T4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

555778:HNEAP RS05440
gene id: 555778:HNEAP_RS05440
uniprot id: D0KZP5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS02500
gene id: 555778:HNEAP_RS02500
uniprot id: D0KY30
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

555778:HNEAP RS07560
gene id: 555778:HNEAP_RS07560
uniprot id: D0L0W6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS03440
gene id: 555778:HNEAP_RS03440
uniprot id: D0KYK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

555778:HNEAP RS05725
gene id: 555778:HNEAP_RS05725
uniprot id: D0KZV3
names: Cofactor
messages: Binds 1 heme c group covalently per subunit.

555778:HNEAP RS01670
gene id: 555778:HNEAP_RS01670
uniprot id: D0KXI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

555778:HNEAP RS07845
gene id: 555778:HNEAP_RS07845
uniprot id: D0L123
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

555778:HNEAP RS07740
gene id: 555778:HNEAP_RS07740
uniprot id: D0L102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

555778:HNEAP RS06235
gene id: 555778:HNEAP_RS06235
uniprot id: D0L054
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

555778:HNEAP RS11885
gene id: 555778:HNEAP_RS11885
uniprot id: D0KXK6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS09745
gene id: 555778:HNEAP_RS09745
uniprot id: D0L258
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

555778:HNEAP RS05775
gene id: 555778:HNEAP_RS05775
uniprot id: D0KZW0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

555778:HNEAP RS00550
gene id: 555778:HNEAP_RS00550
uniprot id: D0KWI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

555778:HNEAP RS02255
gene id: 555778:HNEAP_RS02255
uniprot id: D0KXY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

555778:HNEAP RS08550
gene id: 555778:HNEAP_RS08550
uniprot id: D0L1G6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS07990
gene id: 555778:HNEAP_RS07990
uniprot id: D0L152
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS08415
gene id: 555778:HNEAP_RS08415
uniprot id: D0L1E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

555778:HNEAP RS09900
gene id: 555778:HNEAP_RS09900
uniprot id: D0KVI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

555778:HNEAP RS01170
gene id: 555778:HNEAP_RS01170
uniprot id: D0KX89
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

555778:HNEAP RS03345
gene id: 555778:HNEAP_RS03345
uniprot id: D0KYJ1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS11660
gene id: 555778:HNEAP_RS11660
uniprot id: D0KX30
names: Similarity
messages: Belongs to the thioredoxin family.

555778:HNEAP RS02055
gene id: 555778:HNEAP_RS02055
uniprot id: D0KXU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS07510
gene id: 555778:HNEAP_RS07510
uniprot id: D0L0V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

555778:HNEAP RS02340
gene id: 555778:HNEAP_RS02340
uniprot id: D0KY03
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

555778:HNEAP RS11095
gene id: 555778:HNEAP_RS11095
uniprot id: D0KWD8
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

555778:HNEAP RS09260
gene id: 555778:HNEAP_RS09260
uniprot id: D0L1W2
names: Similarity
messages: Belongs to the histone deacetylase family.

555778:HNEAP RS00685
gene id: 555778:HNEAP_RS00685
uniprot id: D0KWL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

555778:HNEAP RS07475
gene id: 555778:HNEAP_RS07475
uniprot id: D0L0V0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

555778:HNEAP RS02320
gene id: 555778:HNEAP_RS02320
uniprot id: D0KXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

555778:HNEAP RS06665
gene id: 555778:HNEAP_RS06665
uniprot id: D0L0E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

555778:HNEAP RS02595
gene id: 555778:HNEAP_RS02595
uniprot id: D0KY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

555778:HNEAP RS11990
gene id: 555778:HNEAP_RS11990
uniprot id: D0KXM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

555778:HNEAP RS06840
gene id: 555778:HNEAP_RS06840
uniprot id: D0L0H6
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

555778:HNEAP RS02635
gene id: 555778:HNEAP_RS02635
uniprot id: D0KY58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS06035
gene id: 555778:HNEAP_RS06035
uniprot id: D0L012
names: Similarity
messages: Belongs to the SufE family.

555778:HNEAP RS07965
gene id: 555778:HNEAP_RS07965
uniprot id: D0L147
names: Function
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
messages: Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.

555778:HNEAP RS04210
gene id: 555778:HNEAP_RS04210
uniprot id: D0KZ02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

555778:HNEAP RS10015
gene id: 555778:HNEAP_RS10015
uniprot id: D0KVK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

555778:HNEAP RS10505
gene id: 555778:HNEAP_RS10505
uniprot id: D0KW25
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

555778:HNEAP RS01690
gene id: 555778:HNEAP_RS01690
uniprot id: D0KXI9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

555778:HNEAP RS03730
gene id: 555778:HNEAP_RS03730
uniprot id: D0KYR3
names: Similarity
messages: Belongs to the WrbA family.

555778:HNEAP RS08895
gene id: 555778:HNEAP_RS08895
uniprot id: D0L1N8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05030
gene id: 555778:HNEAP_RS05030
uniprot id: D0KZG2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09785
gene id: 555778:HNEAP_RS09785
uniprot id: D0KVF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

555778:HNEAP RS11205
gene id: 555778:HNEAP_RS11205
uniprot id: D0KWU2
names: Similarity
messages: Belongs to the ArsC family.

555778:HNEAP RS09115
gene id: 555778:HNEAP_RS09115
uniprot id: D0L1T2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

555778:HNEAP RS07910
gene id: 555778:HNEAP_RS07910
uniprot id: D0L136
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

555778:HNEAP RS10010
gene id: 555778:HNEAP_RS10010
uniprot id: D0KVK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

555778:HNEAP RS10355
gene id: 555778:HNEAP_RS10355
uniprot id: D0KVR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

555778:HNEAP RS07735
gene id: 555778:HNEAP_RS07735
uniprot id: D0L101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

555778:HNEAP RS06355
gene id: 555778:HNEAP_RS06355
uniprot id: D0L079
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS10890
gene id: 555778:HNEAP_RS10890
uniprot id: D0KW97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

555778:HNEAP RS11075
gene id: 555778:HNEAP_RS11075
uniprot id: D0KWD4
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS01575
gene id: 555778:HNEAP_RS01575
uniprot id: D0KXG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

555778:HNEAP RS12285
gene id: 555778:HNEAP_RS12285
uniprot id: D0L168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26C family.
messages: Periplasm

555778:HNEAP RS05895
gene id: 555778:HNEAP_RS05895
uniprot id: D0KZY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

555778:HNEAP RS04620
gene id: 555778:HNEAP_RS04620
uniprot id: P45690
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
messages: Carboxysome
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212, PubMed:30305640). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131).
messages: Homohexamer with a small central pore (By similarity). Interacts with the N-terminus (residues 1-136) of RuBisCO (CbbL) (PubMed:30305640).
messages: One of shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered. Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome (By similarity). The shell probably limits the diffusion of CO(2) into and out of the carboxysome (Probable). There are estimated to be 540 CsoS1B proteins per carboxysome (Ref.4).
messages: Required for growth in ambient air.
messages: The tight homohexamer forms a small pore which is positively charged.
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS06705
gene id: 555778:HNEAP_RS06705
uniprot id: D0L0E8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

555778:HNEAP RS07920
gene id: 555778:HNEAP_RS07920
uniprot id: D0L138
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

555778:HNEAP RS04565
gene id: 555778:HNEAP_RS04565
uniprot id: D0KZ73
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EutL/PduB family.
messages: Carboxysome
messages: Contains 2 BMC domains, trimerizes in a staggered manner to give a hexamer; each subunit in one trimer interacts with 2 subunits in the facing trimer. Each stacked hexamer can form a pore of about 14 Angstroms in diameter. Dimerization of the trimers forms a channel-like compartment, accessible via an open pore. This channel may be large enough to accomodate transport of substrates into and out of the carboxysome.
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131).
messages: Homotrimer. Forms a dimer of stacked trimers, the same faces interact. Probably forms a CsoS1-CsoS1D-CsoS2 complex.
messages: Not required for growth in ambient air.
messages: Part of the carboxysome shell, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, cbbL-cbbS) is sequestered. It may control transport of RuBisCO reactants in and out of the carboxysome (By similarity). In an E.coli expression system not absolutely necessary, its presence leads to fewer defective carboxysomes, suggesting this subunit may play a role in assembly (PubMed:22184212).
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS11860
gene id: 555778:HNEAP_RS11860
uniprot id: D0KXK1
names: Similarity
messages: Belongs to the glutamine synthetase family.

555778:HNEAP RS11565
gene id: 555778:HNEAP_RS11565
uniprot id: D0KX11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

555778:HNEAP RS01910
gene id: 555778:HNEAP_RS01910
uniprot id: D0KXR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

555778:HNEAP RS08830
gene id: 555778:HNEAP_RS08830
uniprot id: D0L1M4
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

555778:HNEAP RS00195
gene id: 555778:HNEAP_RS00195
uniprot id: D0KVX8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

555778:HNEAP RS08765
gene id: 555778:HNEAP_RS08765
uniprot id: D0L1L1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

555778:HNEAP RS09470
gene id: 555778:HNEAP_RS09470
uniprot id: D0L204
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

555778:HNEAP RS01195
gene id: 555778:HNEAP_RS01195
uniprot id: D0KX95
names: Similarity
messages: Belongs to the YoeB family.

555778:HNEAP RS09145
gene id: 555778:HNEAP_RS09145
uniprot id: D0L1T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

555778:HNEAP RS01215
gene id: 555778:HNEAP_RS01215
uniprot id: D0KXA0
names: Similarity
messages: Belongs to the OprB family.

555778:HNEAP RS05685
gene id: 555778:HNEAP_RS05685
uniprot id: D0KZU5
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

555778:HNEAP RS01290
gene id: 555778:HNEAP_RS01290
uniprot id: D0KXB5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

555778:HNEAP RS01005
gene id: 555778:HNEAP_RS01005
uniprot id: D0KWS2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

555778:HNEAP RS02080
gene id: 555778:HNEAP_RS02080
uniprot id: D0KXV2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02445
gene id: 555778:HNEAP_RS02445
uniprot id: D0KY19
names: Similarity
messages: Belongs to the ABC transporter superfamily.

555778:HNEAP RS02085
gene id: 555778:HNEAP_RS02085
uniprot id: D0KXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS06990
gene id: 555778:HNEAP_RS06990
uniprot id: D0L0K6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

555778:HNEAP RS01705
gene id: 555778:HNEAP_RS01705
uniprot id: D0KXJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

555778:HNEAP RS01570
gene id: 555778:HNEAP_RS01570
uniprot id: D0KXG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

555778:HNEAP RS08940
gene id: 555778:HNEAP_RS08940
uniprot id: D0L1P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

555778:HNEAP RS03605
gene id: 555778:HNEAP_RS03605
uniprot id: D0KYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

555778:HNEAP RS01750
gene id: 555778:HNEAP_RS01750
uniprot id: D0KXP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

555778:HNEAP RS08250
gene id: 555778:HNEAP_RS08250
uniprot id: D0L1A6
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

555778:HNEAP RS07305
gene id: 555778:HNEAP_RS07305
uniprot id: D0L0R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

555778:HNEAP RS03140
gene id: 555778:HNEAP_RS03140
uniprot id: D0KYF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

555778:HNEAP RS08770
gene id: 555778:HNEAP_RS08770
uniprot id: D0L1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

555778:HNEAP RS00220
gene id: 555778:HNEAP_RS00220
uniprot id: D0KVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

555778:HNEAP RS07665
gene id: 555778:HNEAP_RS07665
uniprot id: D0L0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

555778:HNEAP RS05375
gene id: 555778:HNEAP_RS05375
uniprot id: D0KZN2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

555778:HNEAP RS09455
gene id: 555778:HNEAP_RS09455
uniprot id: D0L201
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

555778:HNEAP RS06640
gene id: 555778:HNEAP_RS06640
uniprot id: D0L0D5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

555778:HNEAP RS12170
gene id: 555778:HNEAP_RS12170
uniprot id: D0KYE4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

555778:HNEAP RS02680
gene id: 555778:HNEAP_RS02680
uniprot id: D0KY67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

555778:HNEAP RS01270
gene id: 555778:HNEAP_RS01270
uniprot id: D0KXB1
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09830
gene id: 555778:HNEAP_RS09830
uniprot id: D0KVG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

555778:HNEAP RS11855
gene id: 555778:HNEAP_RS11855
uniprot id: D0KXK0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS06560
gene id: 555778:HNEAP_RS06560
uniprot id: D0L0B9
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS00885
gene id: 555778:HNEAP_RS00885
uniprot id: D0KWP8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05600
gene id: 555778:HNEAP_RS05600
uniprot id: D0KZS8
names: Similarity
messages: Belongs to the CmpA/NrtA family.

555778:HNEAP RS03865
gene id: 555778:HNEAP_RS03865
uniprot id: D0KYU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS03135
gene id: 555778:HNEAP_RS03135
uniprot id: D0KYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

555778:HNEAP RS08545
gene id: 555778:HNEAP_RS08545
uniprot id: D0L1G5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06390
gene id: 555778:HNEAP_RS06390
uniprot id: D0L086
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

555778:HNEAP RS06920
gene id: 555778:HNEAP_RS06920
uniprot id: D0L0J2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

555778:HNEAP RS01640
gene id: 555778:HNEAP_RS01640
uniprot id: D0KXH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

555778:HNEAP RS06970
gene id: 555778:HNEAP_RS06970
uniprot id: D0L0K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

555778:HNEAP RS04060
gene id: 555778:HNEAP_RS04060
uniprot id: D0KYX6
names: Similarity
messages: Belongs to the P(II) protein family.

555778:HNEAP RS05435
gene id: 555778:HNEAP_RS05435
uniprot id: D0KZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

555778:HNEAP RS00515
gene id: 555778:HNEAP_RS00515
uniprot id: D0KWH7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

555778:HNEAP RS02790
gene id: 555778:HNEAP_RS02790
uniprot id: D0KY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

555778:HNEAP RS02230
gene id: 555778:HNEAP_RS02230
uniprot id: D0KXY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

555778:HNEAP RS01305
gene id: 555778:HNEAP_RS01305
uniprot id: D0KXB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

555778:HNEAP RS02395
gene id: 555778:HNEAP_RS02395
uniprot id: D0KY11
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

555778:HNEAP RS00785
gene id: 555778:HNEAP_RS00785
uniprot id: D0KWN0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS07355
gene id: 555778:HNEAP_RS07355
uniprot id: D0L0S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

555778:HNEAP RS06445
gene id: 555778:HNEAP_RS06445
uniprot id: D0L097
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

555778:HNEAP RS03005
gene id: 555778:HNEAP_RS03005
uniprot id: D0KYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS09710
gene id: 555778:HNEAP_RS09710
uniprot id: D0L251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

555778:HNEAP RS00040
gene id: 555778:HNEAP_RS00040
uniprot id: D0KVU5
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS00715
gene id: 555778:HNEAP_RS00715
uniprot id: D0KWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

555778:HNEAP RS10815
gene id: 555778:HNEAP_RS10815
uniprot id: D0KW82
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS10180
gene id: 555778:HNEAP_RS10180
uniprot id: D0KVN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

555778:HNEAP RS01135
gene id: 555778:HNEAP_RS01135
uniprot id: D0KX81
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

555778:HNEAP RS00535
gene id: 555778:HNEAP_RS00535
uniprot id: D0KWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

555778:HNEAP RS02600
gene id: 555778:HNEAP_RS02600
uniprot id: D0KY49
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

555778:HNEAP RS09240
gene id: 555778:HNEAP_RS09240
uniprot id: D0L1V8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS11905
gene id: 555778:HNEAP_RS11905
uniprot id: D0KXL0
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

555778:HNEAP RS09970
gene id: 555778:HNEAP_RS09970
uniprot id: D0KVJ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

555778:HNEAP RS11575
gene id: 555778:HNEAP_RS11575
uniprot id: D0KX13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

555778:HNEAP RS08565
gene id: 555778:HNEAP_RS08565
uniprot id: D0L1G9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

555778:HNEAP RS10690
gene id: 555778:HNEAP_RS10690
uniprot id: D0KW58
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS04485
gene id: 555778:HNEAP_RS04485
uniprot id: D0KZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

555778:HNEAP RS12300
gene id: 555778:HNEAP_RS12300
uniprot id: D0L1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrbI/VirB10 family.
messages: Membrane

555778:HNEAP RS00175
gene id: 555778:HNEAP_RS00175
uniprot id: D0KVX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

555778:HNEAP RS01605
gene id: 555778:HNEAP_RS01605
uniprot id: D0KXH2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

555778:HNEAP RS10175
gene id: 555778:HNEAP_RS10175
uniprot id: D0KVN4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

555778:HNEAP RS02015
gene id: 555778:HNEAP_RS02015
uniprot id: D0KXT9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

555778:HNEAP RS01285
gene id: 555778:HNEAP_RS01285
uniprot id: D0KXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

555778:HNEAP RS03580
gene id: 555778:HNEAP_RS03580
uniprot id: D0KYN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

555778:HNEAP RS10340
gene id: 555778:HNEAP_RS10340
uniprot id: D0KVR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

555778:HNEAP RS03050
gene id: 555778:HNEAP_RS03050
uniprot id: D0KYD2
names: Subcellular Location Annotation
messages: Mitochondrion

555778:HNEAP RS10210
gene id: 555778:HNEAP_RS10210
uniprot id: D0KVP1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

555778:HNEAP RS06435
gene id: 555778:HNEAP_RS06435
uniprot id: D0L095
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS01595
gene id: 555778:HNEAP_RS01595
uniprot id: D0KXH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

555778:HNEAP RS08720
gene id: 555778:HNEAP_RS08720
uniprot id: D0L1K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

555778:HNEAP RS02205
gene id: 555778:HNEAP_RS02205
uniprot id: D0KXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

555778:HNEAP RS09445
gene id: 555778:HNEAP_RS09445
uniprot id: D0L1Z9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06400
gene id: 555778:HNEAP_RS06400
uniprot id: D0L088
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

555778:HNEAP RS02510
gene id: 555778:HNEAP_RS02510
uniprot id: D0KY32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

555778:HNEAP RS01045
gene id: 555778:HNEAP_RS01045
uniprot id: D0KX63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

555778:HNEAP RS09740
gene id: 555778:HNEAP_RS09740
uniprot id: D0L257
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS09665
gene id: 555778:HNEAP_RS09665
uniprot id: D0KY11
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

555778:HNEAP RS03090
gene id: 555778:HNEAP_RS03090
uniprot id: D0KYE2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

555778:HNEAP RS08990
gene id: 555778:HNEAP_RS08990
uniprot id: D0L1Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

555778:HNEAP RS00330
gene id: 555778:HNEAP_RS00330
uniprot id: D0KW06
names: Subunit
messages: Monomer.

555778:HNEAP RS11330
gene id: 555778:HNEAP_RS11330
uniprot id: D0KWW6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

555778:HNEAP RS07505
gene id: 555778:HNEAP_RS07505
uniprot id: D0L0V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

555778:HNEAP RS00935
gene id: 555778:HNEAP_RS00935
uniprot id: D0KWQ8
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

555778:HNEAP RS07885
gene id: 555778:HNEAP_RS07885
uniprot id: D0L131
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05130
gene id: 555778:HNEAP_RS05130
uniprot id: D0KZI3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS05470
gene id: 555778:HNEAP_RS05470
uniprot id: D0KZQ1
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

555778:HNEAP RS11695
gene id: 555778:HNEAP_RS11695
uniprot id: D0KX37
names: Similarity
messages: Belongs to the thioredoxin family.

555778:HNEAP RS10395
gene id: 555778:HNEAP_RS10395
uniprot id: D0KVS8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

555778:HNEAP RS02925
gene id: 555778:HNEAP_RS02925
uniprot id: D0KYA8
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

555778:HNEAP RS01610
gene id: 555778:HNEAP_RS01610
uniprot id: D0KXH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

555778:HNEAP RS05830
gene id: 555778:HNEAP_RS05830
uniprot id: D0KZX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

555778:HNEAP RS05875
gene id: 555778:HNEAP_RS05875
uniprot id: D0KZY0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

555778:HNEAP RS01935
gene id: 555778:HNEAP_RS01935
uniprot id: D0KXS3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

555778:HNEAP RS11840
gene id: 555778:HNEAP_RS11840
uniprot id: D0KXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

555778:HNEAP RS02650
gene id: 555778:HNEAP_RS02650
uniprot id: D0KY61
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

555778:HNEAP RS01505
gene id: 555778:HNEAP_RS01505
uniprot id: D0KXF7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS08420
gene id: 555778:HNEAP_RS08420
uniprot id: D0L1E1
names: Similarity
messages: Belongs to the LOG family.

555778:HNEAP RS06950
gene id: 555778:HNEAP_RS06950
uniprot id: D0L0J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

555778:HNEAP RS03320
gene id: 555778:HNEAP_RS03320
uniprot id: D0KYI6
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

555778:HNEAP RS01970
gene id: 555778:HNEAP_RS01970
uniprot id: D0KXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

555778:HNEAP RS09390
gene id: 555778:HNEAP_RS09390
uniprot id: D0L1Y8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

555778:HNEAP RS11285
gene id: 555778:HNEAP_RS11285
uniprot id: D0KWV6
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

555778:HNEAP RS06645
gene id: 555778:HNEAP_RS06645
uniprot id: D0L0D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

555778:HNEAP RS00955
gene id: 555778:HNEAP_RS00955
uniprot id: D0KWR2
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

555778:HNEAP RS07855
gene id: 555778:HNEAP_RS07855
uniprot id: D0L125
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

555778:HNEAP RS12310
gene id: 555778:HNEAP_RS12310
uniprot id: D0L1C3
names: Similarity
messages: Belongs to the ParB family.

555778:HNEAP RS03330
gene id: 555778:HNEAP_RS03330
uniprot id: D0KYI8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS08885
gene id: 555778:HNEAP_RS08885
uniprot id: D0L1N6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS01255
gene id: 555778:HNEAP_RS01255
uniprot id: D0KXA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

555778:HNEAP RS08600
gene id: 555778:HNEAP_RS08600
uniprot id: D0L1H6
names: Similarity
messages: Belongs to the UPF0434 family.

555778:HNEAP RS06155
gene id: 555778:HNEAP_RS06155
uniprot id: D0L037
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

555778:HNEAP RS10060
gene id: 555778:HNEAP_RS10060
uniprot id: D0KVL3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

555778:HNEAP RS10320
gene id: 555778:HNEAP_RS10320
uniprot id: D0KVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

555778:HNEAP RS03510
gene id: 555778:HNEAP_RS03510
uniprot id: D0KYM2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05855
gene id: 555778:HNEAP_RS05855
uniprot id: D0KZX6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS11585
gene id: 555778:HNEAP_RS11585
uniprot id: D0KX15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

555778:HNEAP RS05080
gene id: 555778:HNEAP_RS05080
uniprot id: D0KZH3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

555778:HNEAP RS02450
gene id: 555778:HNEAP_RS02450
uniprot id: D0KY20
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

555778:HNEAP RS03720
gene id: 555778:HNEAP_RS03720
uniprot id: D0KYR1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

555778:HNEAP RS01725
gene id: 555778:HNEAP_RS01725
uniprot id: D0KXN7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

555778:HNEAP RS01695
gene id: 555778:HNEAP_RS01695
uniprot id: D0KXJ0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

555778:HNEAP RS11655
gene id: 555778:HNEAP_RS11655
uniprot id: D0KX29
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

555778:HNEAP RS01930
gene id: 555778:HNEAP_RS01930
uniprot id: D0KXS1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

555778:HNEAP RS06440
gene id: 555778:HNEAP_RS06440
uniprot id: D0L096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

555778:HNEAP RS03755
gene id: 555778:HNEAP_RS03755
uniprot id: D0KYR8
names: Similarity
messages: Belongs to the asparagine synthetase family.

555778:HNEAP RS01985
gene id: 555778:HNEAP_RS01985
uniprot id: D0KXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

555778:HNEAP RS08790
gene id: 555778:HNEAP_RS08790
uniprot id: D0L1L6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

555778:HNEAP RS00710
gene id: 555778:HNEAP_RS00710
uniprot id: D0KWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS01785
gene id: 555778:HNEAP_RS01785
uniprot id: D0KXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

555778:HNEAP RS03250
gene id: 555778:HNEAP_RS03250
uniprot id: D0KYH2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05970
gene id: 555778:HNEAP_RS05970
uniprot id: D0KZZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell inner membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01715
gene id: 555778:HNEAP_RS01715
uniprot id: D0KXJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

555778:HNEAP RS05385
gene id: 555778:HNEAP_RS05385
uniprot id: D0KZN4
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

555778:HNEAP RS00125
gene id: 555778:HNEAP_RS00125
uniprot id: D0KVW4
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

555778:HNEAP RS11850
gene id: 555778:HNEAP_RS11850
uniprot id: D0KXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

555778:HNEAP RS06725
gene id: 555778:HNEAP_RS06725
uniprot id: D0L0F3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

555778:HNEAP RS04625
gene id: 555778:HNEAP_RS04625
uniprot id: P45689
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
messages: Carboxysome
messages: Does not grow in ambient air, has a wild-type growth rate in 5% CO(2), called a high-CO(2) requiring phenotype, hcr. Fewer carboxysomes are present, RuBisCO is found to be soluble rather than in the carboxysome. Required for growth in ambient air (PubMed:31406332).
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212, PubMed:30305640). Artificial Cb assembly in E.coli requires csoS2-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D (but not the gene for carbonic anhydrase, csoS3). Targeting proteins to the organelle requires at least one of the CsoS2 C-repeats; 3 repeats gives the best localization. A nanoreactor of the Cb shell proteins has been engineered which generates H(2) using a ferredoxin-hydrogenase fusion (AC P07839-Q9FYU1) and a flavodoxin/ferredoxin--NADP reductase (AC A0A0K3QZA5) targeted separately to the Cb; the hydrogenase has first to be matured and activated by HydGXEF (AC Q8EAH9, Q8EAH8, Q8EAH7 and Q8EAH6 respectively). Encapsulation increases H(2) production about 20% during anaerobic growth, and over 4-fold more during aerobic growth (PubMed:33116131). When this gene is expressed in S.elongatus PCC 7942 it colocalizes with its beta-carboxysomes, suggesting there a range of modular possibilites for the carboxysome constituent proteins. These experiments open the door to generating carboxysomes in plant cells to increase their photosynthesis and productivity, as well as tailoring bacterial microcompartments to specific metabolic needs and molecule delivery.
messages: Homohexamer with a small central pore; the concave side is mostly positive electrostatic potential, whereas the convex side is mostly negative electrostatic potential (PubMed:17518518). Forms a CsoS2-CsoS1-RuBisCO complex (Probable). Interacts with the N-terminus (residues 1-136) of RuBisCO (CbbL) (PubMed:30305640).
messages: The major shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, ccbL-ccbS) is sequestered (PubMed:7934888, PubMed:16535117). Assembles into hexamers which make sheets that form the facets of the polyhedral carboxysome (PubMed:17518518). The shell probably limits the diffusion of CO(2) into and out of the carboxysome (Probable). Molecular modeling shows the central pore of this protein is selectively permeable to anions such as HCO(3) rather than CO(2) or O(2) (Probable). There are estimated to be 2970 CsoS1A/CsoS1C proteins per carboxysome (the proteins differ by only 1 residue) (Ref.5).
messages: The tight homohexamer forms a pore with an opening of about 4 Angstroms in diameter which is positively charged.
messages: Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein. CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb. The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices. CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.

555778:HNEAP RS10510
gene id: 555778:HNEAP_RS10510
uniprot id: D0KW26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

555778:HNEAP RS09680
gene id: 555778:HNEAP_RS09680
uniprot id: D0L245
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS04865
gene id: 555778:HNEAP_RS04865
uniprot id: D0KZD5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

555778:HNEAP RS07590
gene id: 555778:HNEAP_RS07590
uniprot id: D0L0X2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS06265
gene id: 555778:HNEAP_RS06265
uniprot id: D0L061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

555778:HNEAP RS03310
gene id: 555778:HNEAP_RS03310
uniprot id: D0KYI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

555778:HNEAP RS05195
gene id: 555778:HNEAP_RS05195
uniprot id: D0KZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

555778:HNEAP RS01030
gene id: 555778:HNEAP_RS01030
uniprot id: D0KWS7
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB2, possibly a heterodimer.
messages: Part of an energy-coupled inorganic carbon pump; its substrate may be carbon dioxide. Expression of both dabA2 and dabB2 (DAB2) restores growth in ambient air to E.coli deleted of its carbonic anhydrase genes (called CAfree, deletion of 'can' and 'cynT'); neither dabA2 or dabB2 alone is sufficient. Rescue is pH-independent, suggesting it transports CO(2) and not carbonate ions. Together the genes allow greater than normal uptake of inorganic carbon by E.coli (PubMed:31406332). Uptake of carbon dioxide rather than bicarbonate has been suggested based on kinetic calculations (Probable).
messages: Required for growth in ambient air.
messages: Uptake of inorganic carbon by cells in the presence of thiosulphate is fully inhibited by the uncouplers carbonyl cyanide m-chlorophenyl hydrazone (CCCP), carbonyl cyanide p-trifluoromethoxyphenyl hydrazone (FCCP), S13 or SF6847. Not inhibited by the ATPase inhibitor N,N-dicyclohexylcarbodiimide (DCCD) (Ref.2). Inorganic carbon uptake is inhibited by the ionophore CCCP, suggesting uptake is coupled to a cation gradient (PubMed:31406332).

555778:HNEAP RS04395
gene id: 555778:HNEAP_RS04395
uniprot id: D0KZ40
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

555778:HNEAP RS05200
gene id: 555778:HNEAP_RS05200
uniprot id: D0KZJ7
names: Similarity
messages: Belongs to the peptidase M1 family.

555778:HNEAP RS11200
gene id: 555778:HNEAP_RS11200
uniprot id: D0KWU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

555778:HNEAP RS06625
gene id: 555778:HNEAP_RS06625
uniprot id: D0L0D2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS06670
gene id: 555778:HNEAP_RS06670
uniprot id: D0L0E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

555778:HNEAP RS02515
gene id: 555778:HNEAP_RS02515
uniprot id: D0KY33
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

555778:HNEAP RS02640
gene id: 555778:HNEAP_RS02640
uniprot id: D0KY59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

555778:HNEAP RS07975
gene id: 555778:HNEAP_RS07975
uniprot id: D0L149
names: Function
names: Similarity
messages: Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
messages: Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.

555778:HNEAP RS01600
gene id: 555778:HNEAP_RS01600
uniprot id: D0KXH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

555778:HNEAP RS01925
gene id: 555778:HNEAP_RS01925
uniprot id: D0KXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

555778:HNEAP RS06505
gene id: 555778:HNEAP_RS06505
uniprot id: D0L0B0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

555778:HNEAP RS11780
gene id: 555778:HNEAP_RS11780
uniprot id: D0KX52
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

555778:HNEAP RS04165
gene id: 555778:HNEAP_RS04165
uniprot id: D0KYZ4
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

555778:HNEAP RS02090
gene id: 555778:HNEAP_RS02090
uniprot id: D0KXV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

555778:HNEAP RS09930
gene id: 555778:HNEAP_RS09930
uniprot id: D0KVI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

555778:HNEAP RS11615
gene id: 555778:HNEAP_RS11615
uniprot id: D0KX21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

555778:HNEAP RS06345
gene id: 555778:HNEAP_RS06345
uniprot id: D0L077
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

555778:HNEAP RS04575
gene id: 555778:HNEAP_RS04575
uniprot id: D0KZ75
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

555778:HNEAP RS06750
gene id: 555778:HNEAP_RS06750
uniprot id: D0L0F8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

555778:HNEAP RS09280
gene id: 555778:HNEAP_RS09280
uniprot id: D0L1W6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

555778:HNEAP RS06065
gene id: 555778:HNEAP_RS06065
uniprot id: D0L019
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

555778:HNEAP RS10875
gene id: 555778:HNEAP_RS10875
uniprot id: D0KW94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

555778:HNEAP RS08755
gene id: 555778:HNEAP_RS08755
uniprot id: D0L1K9
names: Similarity
messages: Belongs to the peptidase S49 family.

555778:HNEAP RS06890
gene id: 555778:HNEAP_RS06890
uniprot id: D0L0I6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

555778:HNEAP RS09620
gene id: 555778:HNEAP_RS09620
uniprot id: D0L233
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10390
gene id: 555778:HNEAP_RS10390
uniprot id: D0KVS7
names: Similarity
messages: Belongs to the Smg family.

555778:HNEAP RS04110
gene id: 555778:HNEAP_RS04110
uniprot id: D0KYY5
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

555778:HNEAP RS03900
gene id: 555778:HNEAP_RS03900
uniprot id: D0KYU7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

555778:HNEAP RS06925
gene id: 555778:HNEAP_RS06925
uniprot id: D0L0J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

555778:HNEAP RS02010
gene id: 555778:HNEAP_RS02010
uniprot id: D0KXT8
names: Similarity
messages: Belongs to the GppA/Ppx family.

555778:HNEAP RS00345
gene id: 555778:HNEAP_RS00345
uniprot id: D0KW10
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

555778:HNEAP RS03600
gene id: 555778:HNEAP_RS03600
uniprot id: D0KYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

555778:HNEAP RS10050
gene id: 555778:HNEAP_RS10050
uniprot id: D0KVL1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10955
gene id: 555778:HNEAP_RS10955
uniprot id: D0KWB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

555778:HNEAP RS09155
gene id: 555778:HNEAP_RS09155
uniprot id: D0L1U0
names: Similarity
messages: Belongs to the GSP E family.

555778:HNEAP RS02695
gene id: 555778:HNEAP_RS02695
uniprot id: D0KY70
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

555778:HNEAP RS04470
gene id: 555778:HNEAP_RS04470
uniprot id: D0KZ54
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS06935
gene id: 555778:HNEAP_RS06935
uniprot id: D0L0J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

555778:HNEAP RS07600
gene id: 555778:HNEAP_RS07600
uniprot id: D0L0X4
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

555778:HNEAP RS07525
gene id: 555778:HNEAP_RS07525
uniprot id: D0L0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

555778:HNEAP RS10075
gene id: 555778:HNEAP_RS10075
uniprot id: D0KVL6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

555778:HNEAP RS05155
gene id: 555778:HNEAP_RS05155
uniprot id: D0KZI8
names: Similarity
messages: Belongs to the pirin family.

555778:HNEAP RS11680
gene id: 555778:HNEAP_RS11680
uniprot id: D0KX34
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

555778:HNEAP RS08560
gene id: 555778:HNEAP_RS08560
uniprot id: D0L1G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

555778:HNEAP RS01035
gene id: 555778:HNEAP_RS01035
uniprot id: D0KWS8
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell inner membrane
messages: Forms a complex with DabA2, possibly a heterodimer.
messages: Part of an energy-coupled inorganic carbon pump; its substrate may be carbon dioxide. Expression of both dabA2 and dabB2 (DAB2) restores growth in ambient air to E.coli deleted of its carbonic anhydrase genes (called CAfree, deletion of 'can' and 'cynT'); neither dabA2 or dabB2 alone is sufficient. Rescue is pH-independent, suggesting it transports CO(2) and not carbonate ions. Together the genes allow greater than normal uptake of inorganic carbon by E.coli (PubMed:31406332). Uptake of carbon dioxide rather than bicarbonate has been suggested based on kinetic calculations (Probable).
messages: Required for growth in ambient air.
messages: Uptake of inorganic carbon by cells in the presence of thiosulphate is fully inhibited by the uncouplers carbonyl cyanide m-chlorophenyl hydrazone (CCCP), carbonyl cyanide p-trifluoromethoxyphenyl hydrazone (FCCP), S13 or SF6847. Not inhibited by the ATPase inhibitor N,N-dicyclohexylcarbodiimide (DCCD) (Ref.2). Inorganic carbon uptake is inhibited by the ionophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP), suggesting uptake is coupled to a cation gradient (PubMed:31406332).

555778:HNEAP RS05625
gene id: 555778:HNEAP_RS05625
uniprot id: D0KZT3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

555778:HNEAP RS04585
gene id: 555778:HNEAP_RS04585
uniprot id: D0KZ77
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB1.
messages: Part of an energy-coupled inorganic carbon pump.
messages: Required for growth in ambient air.

555778:HNEAP RS06085
gene id: 555778:HNEAP_RS06085
uniprot id: D0L022
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

555778:HNEAP RS07255
gene id: 555778:HNEAP_RS07255
uniprot id: D0L0Q7
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS06555
gene id: 555778:HNEAP_RS06555
uniprot id: D0L0B8
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

555778:HNEAP RS07455
gene id: 555778:HNEAP_RS07455
uniprot id: D0L0U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

555778:HNEAP RS11590
gene id: 555778:HNEAP_RS11590
uniprot id: D0KX16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

555778:HNEAP RS04595
gene id: 555778:HNEAP_RS04595
uniprot id: D0KZ79
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell inner membrane
messages: Forms a complex with DabA1.
messages: Part of an energy-coupled inorganic carbon pump.
messages: Required for growth in ambient air.

555778:HNEAP RS02060
gene id: 555778:HNEAP_RS02060
uniprot id: D0KXU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

555778:HNEAP RS01675
gene id: 555778:HNEAP_RS01675
uniprot id: D0KXI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

555778:HNEAP RS11630
gene id: 555778:HNEAP_RS11630
uniprot id: D0KX24
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

555778:HNEAP RS03530
gene id: 555778:HNEAP_RS03530
uniprot id: D0KYM6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

555778:HNEAP RS10860
gene id: 555778:HNEAP_RS10860
uniprot id: D0KW91
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS10670
gene id: 555778:HNEAP_RS10670
uniprot id: D0KW54
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

555778:HNEAP RS03145
gene id: 555778:HNEAP_RS03145
uniprot id: D0KYF1
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

555778:HNEAP RS03880
gene id: 555778:HNEAP_RS03880
uniprot id: D0KYU4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

555778:HNEAP RS10080
gene id: 555778:HNEAP_RS10080
uniprot id: D0KVL7
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

555778:HNEAP RS11930
gene id: 555778:HNEAP_RS11930
uniprot id: D0KXL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

555778:HNEAP RS04980
gene id: 555778:HNEAP_RS04980
uniprot id: D0KZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

555778:HNEAP RS03535
gene id: 555778:HNEAP_RS03535
uniprot id: D0KYM7
names: Function
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

555778:HNEAP RS09350
gene id: 555778:HNEAP_RS09350
uniprot id: D0L1Y0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

555778:HNEAP RS05565
gene id: 555778:HNEAP_RS05565
uniprot id: D0KZS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

555778:HNEAP RS08795
gene id: 555778:HNEAP_RS08795
uniprot id: D0L1L7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

555778:HNEAP RS04255
gene id: 555778:HNEAP_RS04255
uniprot id: D0KZ11
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS00820
gene id: 555778:HNEAP_RS00820
uniprot id: D0KWN5
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS08535
gene id: 555778:HNEAP_RS08535
uniprot id: D0L1G3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.

555778:HNEAP RS09755
gene id: 555778:HNEAP_RS09755
uniprot id: D0L260
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS05255
gene id: 555778:HNEAP_RS05255
uniprot id: D0KZK8
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

555778:HNEAP RS08825
gene id: 555778:HNEAP_RS08825
uniprot id: D0L1M3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

555778:HNEAP RS02455
gene id: 555778:HNEAP_RS02455
uniprot id: D0KY21
names: Similarity
messages: Belongs to the phosphohexose mutase family.

555778:HNEAP RS06270
gene id: 555778:HNEAP_RS06270
uniprot id: D0L062
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

555778:HNEAP RS01200
gene id: 555778:HNEAP_RS01200
uniprot id: D0KX96
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

555778:HNEAP RS03875
gene id: 555778:HNEAP_RS03875
uniprot id: D0KYU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

555778:HNEAP RS08500
gene id: 555778:HNEAP_RS08500
uniprot id: D0L1F7
names: Similarity
messages: Belongs to the UPF0225 family.

555778:HNEAP RS06375
gene id: 555778:HNEAP_RS06375
uniprot id: D0L083
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

555778:HNEAP RS08070
gene id: 555778:HNEAP_RS08070
uniprot id: D0L169
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS08395
gene id: 555778:HNEAP_RS08395
uniprot id: D0L1D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

555778:HNEAP RS01420
gene id: 555778:HNEAP_RS01420
uniprot id: D0KXE0
names: Similarity
messages: Belongs to the UPF0276 family.

555778:HNEAP RS04745
gene id: 555778:HNEAP_RS04745
uniprot id: D0KZA8
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

555778:HNEAP RS06130
gene id: 555778:HNEAP_RS06130
uniprot id: D0L032
names: Similarity
messages: Belongs to the Dps family.

555778:HNEAP RS01685
gene id: 555778:HNEAP_RS01685
uniprot id: D0KXI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

555778:HNEAP RS08125
gene id: 555778:HNEAP_RS08125
uniprot id: D0L181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TraY family.
messages: Cytoplasm

555778:HNEAP RS10840
gene id: 555778:HNEAP_RS10840
uniprot id: D0KW87
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

555778:HNEAP RS09505
gene id: 555778:HNEAP_RS09505
uniprot id: D0L210
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

555778:HNEAP RS06330
gene id: 555778:HNEAP_RS06330
uniprot id: D0L074
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05805
gene id: 555778:HNEAP_RS05805
uniprot id: D0KZW6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS09585
gene id: 555778:HNEAP_RS09585
uniprot id: D0L226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

555778:HNEAP RS01405
gene id: 555778:HNEAP_RS01405
uniprot id: D0KXD8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

555778:HNEAP RS12015
gene id: 555778:HNEAP_RS12015
uniprot id: D0KXN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

555778:HNEAP RS05890
gene id: 555778:HNEAP_RS05890
uniprot id: D0KZY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

555778:HNEAP RS00930
gene id: 555778:HNEAP_RS00930
uniprot id: D0KWQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

555778:HNEAP RS07635
gene id: 555778:HNEAP_RS07635
uniprot id: D0L0Y2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS04215
gene id: 555778:HNEAP_RS04215
uniprot id: D0KZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

555778:HNEAP RS02910
gene id: 555778:HNEAP_RS02910
uniprot id: D0KYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

555778:HNEAP RS09690
gene id: 555778:HNEAP_RS09690
uniprot id: D0L247
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05660
gene id: 555778:HNEAP_RS05660
uniprot id: D0KZU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS00740
gene id: 555778:HNEAP_RS00740
uniprot id: D0KWM1
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS01555
gene id: 555778:HNEAP_RS01555
uniprot id: D0KXG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

555778:HNEAP RS10205
gene id: 555778:HNEAP_RS10205
uniprot id: D0KVP0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS02530
gene id: 555778:HNEAP_RS02530
uniprot id: D0KY36
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02540
gene id: 555778:HNEAP_RS02540
uniprot id: D0KY38
names: Similarity
messages: Belongs to the BolA/IbaG family.

555778:HNEAP RS01995
gene id: 555778:HNEAP_RS01995
uniprot id: D0KXT5
names: Similarity
messages: Belongs to the peptidase S13 family.

555778:HNEAP RS05950
gene id: 555778:HNEAP_RS05950
uniprot id: D0KZZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

555778:HNEAP RS00255
gene id: 555778:HNEAP_RS00255
uniprot id: D0KVZ1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

555778:HNEAP RS08520
gene id: 555778:HNEAP_RS08520
uniprot id: D0L1G1
names: Similarity
messages: Belongs to the DinB family.

555778:HNEAP RS03820
gene id: 555778:HNEAP_RS03820
uniprot id: D0KYT2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

555778:HNEAP RS02660
gene id: 555778:HNEAP_RS02660
uniprot id: D0KY63
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

555778:HNEAP RS02655
gene id: 555778:HNEAP_RS02655
uniprot id: D0KY62
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

555778:HNEAP RS07235
gene id: 555778:HNEAP_RS07235
uniprot id: D0L0Q4
names: Similarity
messages: Belongs to the skp family.

555778:HNEAP RS08930
gene id: 555778:HNEAP_RS08930
uniprot id: D0L1P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS09810
gene id: 555778:HNEAP_RS09810
uniprot id: D0KVG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

555778:HNEAP RS06430
gene id: 555778:HNEAP_RS06430
uniprot id: D0L094
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

555778:HNEAP RS08965
gene id: 555778:HNEAP_RS08965
uniprot id: D0L1Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

555778:HNEAP RS08810
gene id: 555778:HNEAP_RS08810
uniprot id: D0L1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

555778:HNEAP RS09150
gene id: 555778:HNEAP_RS09150
uniprot id: D0L1T9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

555778:HNEAP RS06280
gene id: 555778:HNEAP_RS06280
uniprot id: D0L064
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

555778:HNEAP RS01780
gene id: 555778:HNEAP_RS01780
uniprot id: D0KXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

555778:HNEAP RS03795
gene id: 555778:HNEAP_RS03795
uniprot id: D0KYS7
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

555778:HNEAP RS13035
gene id: 555778:HNEAP_RS13035
uniprot id: D0KX79
names: Similarity
messages: Belongs to the N-Me-Phe pilin family.

555778:HNEAP RS03630
gene id: 555778:HNEAP_RS03630
uniprot id: D0KYP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

555778:HNEAP RS11000
gene id: 555778:HNEAP_RS11000
uniprot id: D0KWB9
names: Similarity
messages: Belongs to the CmpA/NrtA family.

555778:HNEAP RS08800
gene id: 555778:HNEAP_RS08800
uniprot id: D0L1L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

555778:HNEAP RS06995
gene id: 555778:HNEAP_RS06995
uniprot id: D0L0K7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

555778:HNEAP RS08110
gene id: 555778:HNEAP_RS08110
uniprot id: D0L177
names: Similarity
messages: Belongs to the GSP E family.

555778:HNEAP RS00135
gene id: 555778:HNEAP_RS00135
uniprot id: D0KVW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

555778:HNEAP RS03055
gene id: 555778:HNEAP_RS03055
uniprot id: D0KYD4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

555778:HNEAP RS04870
gene id: 555778:HNEAP_RS04870
uniprot id: D0KZD6
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

555778:HNEAP RS09195
gene id: 555778:HNEAP_RS09195
uniprot id: D0L1U9
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

555778:HNEAP RS02990
gene id: 555778:HNEAP_RS02990
uniprot id: D0KYC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

555778:HNEAP RS05190
gene id: 555778:HNEAP_RS05190
uniprot id: D0KZJ5
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

555778:HNEAP RS00500
gene id: 555778:HNEAP_RS00500
uniprot id: D0KWH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

555778:HNEAP RS05535
gene id: 555778:HNEAP_RS05535
uniprot id: D0KZR5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS10495
gene id: 555778:HNEAP_RS10495
uniprot id: D0KW23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

555778:HNEAP RS02685
gene id: 555778:HNEAP_RS02685
uniprot id: D0KY68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

555778:HNEAP RS05035
gene id: 555778:HNEAP_RS05035
uniprot id: D0KZG3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Belongs to the heat shock protein 70 family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS12790
gene id: 555778:HNEAP_RS12790
uniprot id: D0L0E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

555778:HNEAP RS10745
gene id: 555778:HNEAP_RS10745
uniprot id: D0KW68
names: Similarity
messages: Belongs to the UPF0758 family.

555778:HNEAP RS07795
gene id: 555778:HNEAP_RS07795
uniprot id: D0L113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS08425
gene id: 555778:HNEAP_RS08425
uniprot id: D0L1E2
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

555778:HNEAP RS06030
gene id: 555778:HNEAP_RS06030
uniprot id: D0L011
names: Similarity
messages: Belongs to the HesB/IscA family.

555778:HNEAP RS07270
gene id: 555778:HNEAP_RS07270
uniprot id: D0L0R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

555778:HNEAP RS00865
gene id: 555778:HNEAP_RS00865
uniprot id: D0KWP4
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

555778:HNEAP RS10025
gene id: 555778:HNEAP_RS10025
uniprot id: D0KVK6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

555778:HNEAP RS01120
gene id: 555778:HNEAP_RS01120
uniprot id: D0KX78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

555778:HNEAP RS06060
gene id: 555778:HNEAP_RS06060
uniprot id: D0L018
names: Similarity
messages: Belongs to the transposase 7 family.

555778:HNEAP RS09765
gene id: 555778:HNEAP_RS09765
uniprot id: D0L262
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS02835
gene id: 555778:HNEAP_RS02835
uniprot id: D0KY92
names: Similarity
messages: Belongs to the phosphoribulokinase family.

555778:HNEAP RS06415
gene id: 555778:HNEAP_RS06415
uniprot id: D0L091
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

555778:HNEAP RS00365
gene id: 555778:HNEAP_RS00365
uniprot id: D0KW14
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

555778:HNEAP RS09770
gene id: 555778:HNEAP_RS09770
uniprot id: D0KVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS12010
gene id: 555778:HNEAP_RS12010
uniprot id: D0KXN1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01530
gene id: 555778:HNEAP_RS01530
uniprot id: D0KXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

555778:HNEAP RS07780
gene id: 555778:HNEAP_RS07780
uniprot id: D0L110
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

555778:HNEAP RS10135
gene id: 555778:HNEAP_RS10135
uniprot id: D0KVM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

555778:HNEAP RS03360
gene id: 555778:HNEAP_RS03360
uniprot id: D0KYJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

555778:HNEAP RS00110
gene id: 555778:HNEAP_RS00110
uniprot id: D0KVW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS03045
gene id: 555778:HNEAP_RS03045
uniprot id: D0KYD1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

555778:HNEAP RS06740
gene id: 555778:HNEAP_RS06740
uniprot id: D0L0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

555778:HNEAP RS01720
gene id: 555778:HNEAP_RS01720
uniprot id: D0KXN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

555778:HNEAP RS01765
gene id: 555778:HNEAP_RS01765
uniprot id: D0KXP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

555778:HNEAP RS10185
gene id: 555778:HNEAP_RS10185
uniprot id: D0KVN6
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

555778:HNEAP RS04130
gene id: 555778:HNEAP_RS04130
uniprot id: D0KYY9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS02070
gene id: 555778:HNEAP_RS02070
uniprot id: D0KXV0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

555778:HNEAP RS07515
gene id: 555778:HNEAP_RS07515
uniprot id: D0L0V7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS09235
gene id: 555778:HNEAP_RS09235
uniprot id: D0L1V7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

555778:HNEAP RS00120
gene id: 555778:HNEAP_RS00120
uniprot id: D0KVW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

555778:HNEAP RS07835
gene id: 555778:HNEAP_RS07835
uniprot id: D0L121
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

555778:HNEAP RS10240
gene id: 555778:HNEAP_RS10240
uniprot id: D0KVP6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

555778:HNEAP RS00680
gene id: 555778:HNEAP_RS00680
uniprot id: D0KWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

555778:HNEAP RS04030
gene id: 555778:HNEAP_RS04030
uniprot id: D0KYX1
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

555778:HNEAP RS04440
gene id: 555778:HNEAP_RS04440
uniprot id: D0KZ48
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

555778:HNEAP RS01655
gene id: 555778:HNEAP_RS01655
uniprot id: D0KXI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

555778:HNEAP RS10020
gene id: 555778:HNEAP_RS10020
uniprot id: D0KVK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

555778:HNEAP RS06710
gene id: 555778:HNEAP_RS06710
uniprot id: D0L0E9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS09530
gene id: 555778:HNEAP_RS09530
uniprot id: D0L215
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

555778:HNEAP RS04125
gene id: 555778:HNEAP_RS04125
uniprot id: D0KYY8
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

555778:HNEAP RS04555
gene id: 555778:HNEAP_RS04555
uniprot id: D0KZ71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS02920
gene id: 555778:HNEAP_RS02920
uniprot id: D0KYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS10115
gene id: 555778:HNEAP_RS10115
uniprot id: D0KVM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

555778:HNEAP RS05585
gene id: 555778:HNEAP_RS05585
uniprot id: D0KZS5
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

555778:HNEAP RS11295
gene id: 555778:HNEAP_RS11295
uniprot id: D0KWV9
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

555778:HNEAP RS05885
gene id: 555778:HNEAP_RS05885
uniprot id: D0KZY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

555778:HNEAP RS01645
gene id: 555778:HNEAP_RS01645
uniprot id: D0KXI0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

555778:HNEAP RS04400
gene id: 555778:HNEAP_RS04400
uniprot id: D0KZ41
names: Similarity
messages: Belongs to the BMP lipoprotein family.

555778:HNEAP RS08775
gene id: 555778:HNEAP_RS08775
uniprot id: D0L1L3
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

555778:HNEAP RS09515
gene id: 555778:HNEAP_RS09515
uniprot id: D0L212
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

555778:HNEAP RS11500
gene id: 555778:HNEAP_RS11500
uniprot id: D0KWZ8
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS01940
gene id: 555778:HNEAP_RS01940
uniprot id: D0KXS4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

555778:HNEAP RS03060
gene id: 555778:HNEAP_RS03060
uniprot id: D0KYD5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

555778:HNEAP RS09290
gene id: 555778:HNEAP_RS09290
uniprot id: D0L1W8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

555778:HNEAP RS08875
gene id: 555778:HNEAP_RS08875
uniprot id: D0L1N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS08240
gene id: 555778:HNEAP_RS08240
uniprot id: D0L1A3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS05105
gene id: 555778:HNEAP_RS05105
uniprot id: D0KZH8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

555778:HNEAP RS09760
gene id: 555778:HNEAP_RS09760
uniprot id: D0L261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS10760
gene id: 555778:HNEAP_RS10760
uniprot id: D0KW71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

555778:HNEAP RS06305
gene id: 555778:HNEAP_RS06305
uniprot id: D0L069
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

555778:HNEAP RS11880
gene id: 555778:HNEAP_RS11880
uniprot id: D0KXK5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

555778:HNEAP RS02125
gene id: 555778:HNEAP_RS02125
uniprot id: D0KXW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

555778:HNEAP RS05515
gene id: 555778:HNEAP_RS05515
uniprot id: D0KZR0
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS12030
gene id: 555778:HNEAP_RS12030
uniprot id: D0KXN5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

555778:HNEAP RS01050
gene id: 555778:HNEAP_RS01050
uniprot id: D0KX64
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

555778:HNEAP RS00575
gene id: 555778:HNEAP_RS00575
uniprot id: D0KWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

555778:HNEAP RS10620
gene id: 555778:HNEAP_RS10620
uniprot id: D0KW49
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS04170
gene id: 555778:HNEAP_RS04170
uniprot id: D0KYZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

555778:HNEAP RS00435
gene id: 555778:HNEAP_RS00435
uniprot id: D0KWG2
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS03350
gene id: 555778:HNEAP_RS03350
uniprot id: D0KYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

555778:HNEAP RS05350
gene id: 555778:HNEAP_RS05350
uniprot id: D0KZM7
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

555778:HNEAP RS09125
gene id: 555778:HNEAP_RS09125
uniprot id: D0L1T4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

555778:HNEAP RS01710
gene id: 555778:HNEAP_RS01710
uniprot id: D0KXJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

555778:HNEAP RS04260
gene id: 555778:HNEAP_RS04260
uniprot id: D0KZ12
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS02615
gene id: 555778:HNEAP_RS02615
uniprot id: D0KY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS08890
gene id: 555778:HNEAP_RS08890
uniprot id: D0L1N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS06260
gene id: 555778:HNEAP_RS06260
uniprot id: D0L060
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

555778:HNEAP RS05780
gene id: 555778:HNEAP_RS05780
uniprot id: D0KZW1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

555778:HNEAP RS08760
gene id: 555778:HNEAP_RS08760
uniprot id: D0L1L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

555778:HNEAP RS08150
gene id: 555778:HNEAP_RS08150
uniprot id: D0L186
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

555778:HNEAP RS05010
gene id: 555778:HNEAP_RS05010
uniprot id: D0KZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

555778:HNEAP RS02895
gene id: 555778:HNEAP_RS02895
uniprot id: D0KYA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

555778:HNEAP RS07765
gene id: 555778:HNEAP_RS07765
uniprot id: D0L107
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS10780
gene id: 555778:HNEAP_RS10780
uniprot id: D0KW75
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

555778:HNEAP RS00825
gene id: 555778:HNEAP_RS00825
uniprot id: D0KWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

555778:HNEAP RS03620
gene id: 555778:HNEAP_RS03620
uniprot id: D0KYP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

555778:HNEAP RS05795
gene id: 555778:HNEAP_RS05795
uniprot id: D0KZW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS02880
gene id: 555778:HNEAP_RS02880
uniprot id: D0KY99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

555778:HNEAP RS11765
gene id: 555778:HNEAP_RS11765
uniprot id: D0KX49
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

555778:HNEAP RS06285
gene id: 555778:HNEAP_RS06285
uniprot id: D0L065
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

555778:HNEAP RS08680
gene id: 555778:HNEAP_RS08680
uniprot id: D0L1J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

555778:HNEAP RS05870
gene id: 555778:HNEAP_RS05870
uniprot id: D0KZX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

555778:HNEAP RS11600
gene id: 555778:HNEAP_RS11600
uniprot id: D0KX18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

555778:HNEAP RS11925
gene id: 555778:HNEAP_RS11925
uniprot id: D0KXL4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

555778:HNEAP RS11980
gene id: 555778:HNEAP_RS11980
uniprot id: D0KXM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

555778:HNEAP RS10055
gene id: 555778:HNEAP_RS10055
uniprot id: D0KVL2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS01975
gene id: 555778:HNEAP_RS01975
uniprot id: D0KXT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

555778:HNEAP RS09540
gene id: 555778:HNEAP_RS09540
uniprot id: D0L217
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

555778:HNEAP RS09450
gene id: 555778:HNEAP_RS09450
uniprot id: D0L200
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

555778:HNEAP RS06225
gene id: 555778:HNEAP_RS06225
uniprot id: D0L052
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

555778:HNEAP RS01435
gene id: 555778:HNEAP_RS01435
uniprot id: D0KXE3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

555778:HNEAP RS02105
gene id: 555778:HNEAP_RS02105
uniprot id: D0KXV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

555778:HNEAP RS12150
gene id: 555778:HNEAP_RS12150
uniprot id: D0KY42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

555778:HNEAP RS07800
gene id: 555778:HNEAP_RS07800
uniprot id: D0L114
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

555778:HNEAP RS05370
gene id: 555778:HNEAP_RS05370
uniprot id: D0KZN1
names: Similarity
messages: Belongs to the UPF0260 family.

555778:HNEAP RS01950
gene id: 555778:HNEAP_RS01950
uniprot id: D0KXS6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

555778:HNEAP RS08745
gene id: 555778:HNEAP_RS08745
uniprot id: D0L1K7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

555778:HNEAP RS01665
gene id: 555778:HNEAP_RS01665
uniprot id: D0KXI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

555778:HNEAP RS08655
gene id: 555778:HNEAP_RS08655
uniprot id: D0L1I8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

555778:HNEAP RS11385
gene id: 555778:HNEAP_RS11385
uniprot id: D0KWX8
names: Similarity
messages: Belongs to the glutamate synthase family.

555778:HNEAP RS06780
gene id: 555778:HNEAP_RS06780
uniprot id: D0L0G4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

555778:HNEAP RS11115
gene id: 555778:HNEAP_RS11115
uniprot id: D0KWE2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

555778:HNEAP RS00675
gene id: 555778:HNEAP_RS00675
uniprot id: D0KWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS10665
gene id: 555778:HNEAP_RS10665
uniprot id: D0KW53
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS01580
gene id: 555778:HNEAP_RS01580
uniprot id: D0KXG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

555778:HNEAP RS05250
gene id: 555778:HNEAP_RS05250
uniprot id: D0KZK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

555778:HNEAP RS01190
gene id: 555778:HNEAP_RS01190
uniprot id: D0KX94
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

555778:HNEAP RS11110
gene id: 555778:HNEAP_RS11110
uniprot id: D0KWE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

555778:HNEAP RS01635
gene id: 555778:HNEAP_RS01635
uniprot id: D0KXH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

555778:HNEAP RS11230
gene id: 555778:HNEAP_RS11230
uniprot id: D0KWU7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

555778:HNEAP RS00165
gene id: 555778:HNEAP_RS00165
uniprot id: D0KVX2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

555778:HNEAP RS05705
gene id: 555778:HNEAP_RS05705
uniprot id: D0KZU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

555778:HNEAP RS05605
gene id: 555778:HNEAP_RS05605
uniprot id: D0KZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

555778:HNEAP RS11835
gene id: 555778:HNEAP_RS11835
uniprot id: D0KXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

555778:HNEAP RS05985
gene id: 555778:HNEAP_RS05985
uniprot id: D0L002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

555778:HNEAP RS03805
gene id: 555778:HNEAP_RS03805
uniprot id: D0KYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

555778:HNEAP RS03085
gene id: 555778:HNEAP_RS03085
uniprot id: D0KYE0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

555778:HNEAP RS02810
gene id: 555778:HNEAP_RS02810
uniprot id: D0KY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS02890
gene id: 555778:HNEAP_RS02890
uniprot id: D0KYA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

555778:HNEAP RS10575
gene id: 555778:HNEAP_RS10575
uniprot id: D0KW39
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS02310
gene id: 555778:HNEAP_RS02310
uniprot id: D0KXZ7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS05055
gene id: 555778:HNEAP_RS05055
uniprot id: D0KZG7
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

555778:HNEAP RS09160
gene id: 555778:HNEAP_RS09160
uniprot id: D0L1U1
names: Similarity
messages: Belongs to the GSP E family.

555778:HNEAP RS09490
gene id: 555778:HNEAP_RS09490
uniprot id: D0L207
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 1 heme group per subunit.
messages: Binds 2 heme groups per subunit.
messages: C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

555778:HNEAP RS06275
gene id: 555778:HNEAP_RS06275
uniprot id: D0L063
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

555778:HNEAP RS08845
gene id: 555778:HNEAP_RS08845
uniprot id: D0L1M7
names: Subcellular Location Annotation
messages: Membrane

555778:HNEAP RS11510
gene id: 555778:HNEAP_RS11510
uniprot id: D0KX00
names: Similarity
messages: Belongs to the bacterial secretin family.

555778:HNEAP RS01540
gene id: 555778:HNEAP_RS01540
uniprot id: D0KXF9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS08650
gene id: 555778:HNEAP_RS08650
uniprot id: D0L1I7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

555778:HNEAP RS08820
gene id: 555778:HNEAP_RS08820
uniprot id: D0L1M2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

555778:HNEAP RS04105
gene id: 555778:HNEAP_RS04105
uniprot id: D0KYY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

555778:HNEAP RS01700
gene id: 555778:HNEAP_RS01700
uniprot id: D0KXJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

555778:HNEAP RS07785
gene id: 555778:HNEAP_RS07785
uniprot id: D0L111
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

555778:HNEAP RS02260
gene id: 555778:HNEAP_RS02260
uniprot id: D0KXY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

555778:HNEAP RS05015
gene id: 555778:HNEAP_RS05015
uniprot id: D0KZF9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

555778:HNEAP RS09685
gene id: 555778:HNEAP_RS09685
uniprot id: D0L246
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

555778:HNEAP RS07640
gene id: 555778:HNEAP_RS07640
uniprot id: D0L0Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

555778:HNEAP RS07340
gene id: 555778:HNEAP_RS07340
uniprot id: D0L0S4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

555778:HNEAP RS04935
gene id: 555778:HNEAP_RS04935
uniprot id: D0KZE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

555778:HNEAP RS05465
gene id: 555778:HNEAP_RS05465
uniprot id: D0KZQ0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

555778:HNEAP RS05700
gene id: 555778:HNEAP_RS05700
uniprot id: D0KZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

555778:HNEAP RS10215
gene id: 555778:HNEAP_RS10215
uniprot id: D0KVP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

555778:HNEAP RS04275
gene id: 555778:HNEAP_RS04275
uniprot id: D0KZ15
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

555778:HNEAP RS07575
gene id: 555778:HNEAP_RS07575
uniprot id: D0L0W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

555778:HNEAP RS05630
gene id: 555778:HNEAP_RS05630
uniprot id: D0KZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.

555778:HNEAP RS07850
gene id: 555778:HNEAP_RS07850
uniprot id: D0L124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

555778:HNEAP RS09345
gene id: 555778:HNEAP_RS09345
uniprot id: D0L1X9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

555778:HNEAP RS06715
gene id: 555778:HNEAP_RS06715
uniprot id: D0L0F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

555778:HNEAP RS09575
gene id: 555778:HNEAP_RS09575
uniprot id: D0L224
names: Similarity
messages: Belongs to the fabD family.

555778:HNEAP RS03065
gene id: 555778:HNEAP_RS03065
uniprot id: D0KYD6
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

555778:HNEAP RS07205
gene id: 555778:HNEAP_RS07205
uniprot id: D0L0P9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

555778:HNEAP RS08935
gene id: 555778:HNEAP_RS08935
uniprot id: D0L1P6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

555778:HNEAP RS02625
gene id: 555778:HNEAP_RS02625
uniprot id: D0KY56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

555778:HNEAP RS01585
gene id: 555778:HNEAP_RS01585
uniprot id: D0KXG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

555778:HNEAP RS03245
gene id: 555778:HNEAP_RS03245
uniprot id: D0KYH1
names: Similarity
messages: Belongs to the PhoH family.

555778:HNEAP RS06490
gene id: 555778:HNEAP_RS06490
uniprot id: D0L0A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS05285
gene id: 555778:HNEAP_RS05285
uniprot id: D0KZL4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

555778:HNEAP RS06795
gene id: 555778:HNEAP_RS06795
uniprot id: D0L0G7
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

555778:HNEAP RS10070
gene id: 555778:HNEAP_RS10070
uniprot id: D0KVL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

555778:HNEAP RS06190
gene id: 555778:HNEAP_RS06190
uniprot id: D0L044
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

555778:HNEAP RS09720
gene id: 555778:HNEAP_RS09720
uniprot id: D0L253
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

555778:HNEAP RS10790
gene id: 555778:HNEAP_RS10790
uniprot id: D0KW77
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

555778:HNEAP RS09780
gene id: 555778:HNEAP_RS09780
uniprot id: D0KVF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

555778:HNEAP RS10030
gene id: 555778:HNEAP_RS10030
uniprot id: D0KVK7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

555778:HNEAP RS03890
gene id: 555778:HNEAP_RS03890
uniprot id: D0KYU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

555778:HNEAP RS11870
gene id: 555778:HNEAP_RS11870
uniprot id: D0KXK3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

555778:HNEAP RS03585
gene id: 555778:HNEAP_RS03585
uniprot id: D0KYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

555778:HNEAP RS10105
gene id: 555778:HNEAP_RS10105
uniprot id: D0KVM1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

555778:HNEAP RS04660
gene id: 555778:HNEAP_RS04660
uniprot id: O85040
names: Biotechnology
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-carboxysomes are able to assemble in the absence of RuBisCO, unlike beta-carboxysomes. The RuBisCO large subunit is required for enzyme integration into carboxysomes; replacing it with the carboxysomally targeted gene (Tcr_0838, AC Q31HD9) of H.crungenus places RuBisCO in the carboxysome, while the non-carboxysomal large subunit of H.crungenus (Tcr_0427, AC Q31IK0) is not incorporated in the carboxysome.
messages: Belongs to the RuBisCO large chain family. Type I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Carboxysome
messages: Does not grow in air, grows poorly in air supplemented with 5% CO(2), a high-CO(2) requiring phenotype (hcr), has apolar effect on expression of downstream cbbS. Expresses type II but not type I RuBisCO, does not form carboxysomes but instead smaller, empty cytoplasmic inclusions (PubMed:9696760). A double ccbL-ccbS deletion is hcr and forms empty but otherwise normal appearing carboxysomes (PubMed:18974784). Required for growth in ambient air (PubMed:31406332).
messages: Expression of 10 genes for alpha-carboxysome (Cb) proteins (cbbL-cbbS-csoS2-csoS3-csoS4A-csoS4B-csoS1C-csoS1A-csoS1B-csoS1D) in E.coli generates compartments that resemble Cb, contain RuBisCO and have its catalytic activity, showing it is possible to make artificial, functional Cb using these 10 genes. Cargo proteins can be targeted to these organelles (PubMed:22184212, PubMed:30305640). Alpha-carboxysomes are assembled in the complete absence of this enzyme in this bacteria, suggesting carboxysome-based microcompartments can be designed for applications such as custom chemical reactors or delivery vehicles (PubMed:18974784). When this gene is expressed in S.elongatus PCC 7942 it colocalizes with its beta-carboxysomes, suggesting there a range of modular possibilites for the carboxysome constituent proteins. These experiments open the door to generating carboxysomes in plant cells to increase their photosynthesis and productivity, as well as tailoring bacterial microcompartments to specific metabolic needs and molecule delivery (PubMed:29922315).
messages: Heterohexadecamer of 8 large chains and 8 small chains (By similarity) (Ref.14). Forms a CsoS2-CsoS1-RuBisCO complex (Probable). The N-terminus (residues 1-136) interacts with shell proteins CsoS1A, CsoS1B and CsoS1C (PubMed:30305640). Holo-RuBisCO interacts with the N-terminal repeats of CsoS2; binding is sensitive to ionic strength. A fusion of a single N-terminal repeat to the C-terminus of the large subunit of RuBisCO (cbbL) shows the repeat can lie between a CbbL dimer, making minor contacts to CbbS; thus each RuBisCO holoenzyme could bind 8 repeats (PubMed:32123388).
messages: Produced when grown in air or in air supplemented with 5% CO(2) (at protein level). Part of the cbbL-cbbS operon.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity) (Ref.3, PubMed:18258595, PubMed:18974784). There are estimated to be 270 RuBisCO heterohexadecamers per carboxysome (Ref.6).
messages: The N-terminus (minimally 1-122, fragment 1-136 does not bind any better) interacts with the shell proteins CsoS1A, CsoS1B and CsoS1C. A slightly longer fragment of the N-terminus (residues 1-136) is required for targeting to carboxysomes, and will direct foreign proteins to the carboxysome, with reduced efficiency compared to the whole protein.
messages: The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'.

555778:HNEAP RS09990
gene id: 555778:HNEAP_RS09990
uniprot id: D0KVJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

555778:HNEAP RS06825
gene id: 555778:HNEAP_RS06825
uniprot id: D0L0H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

555778:HNEAP RS08840
gene id: 555778:HNEAP_RS08840
uniprot id: D0L1M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

555778:HNEAP RS11595
gene id: 555778:HNEAP_RS11595
uniprot id: D0KX17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

555778:HNEAP RS08870
gene id: 555778:HNEAP_RS08870
uniprot id: D0L1N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

555778:HNEAP RS09985
gene id: 555778:HNEAP_RS09985
uniprot id: D0KVJ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

555778:HNEAP RS05005
gene id: 555778:HNEAP_RS05005
uniprot id: D0KZF7
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

555778:HNEAP RS03930
gene id: 555778:HNEAP_RS03930
uniprot id: D0KYV3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

555778:HNEAP RS01660
gene id: 555778:HNEAP_RS01660
uniprot id: D0KXI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.