547558:MMAH RS04360
gene id: 547558:MMAH_RS04360
uniprot id: D5EB34
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

547558:MMAH RS03490
gene id: 547558:MMAH_RS03490
uniprot id: D5EAL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS09455
gene id: 547558:MMAH_RS09455
uniprot id: D5E8A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

547558:MMAH RS07265
gene id: 547558:MMAH_RS07265
uniprot id: D5E723
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

547558:MMAH RS06165
gene id: 547558:MMAH_RS06165
uniprot id: D5EC37
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

547558:MMAH RS09560
gene id: 547558:MMAH_RS09560
uniprot id: D5E8C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07225
gene id: 547558:MMAH_RS07225
uniprot id: D5E715
names: Similarity
messages: Belongs to the Ahb/Nir family.

547558:MMAH RS08645
gene id: 547558:MMAH_RS08645
uniprot id: D5E7U2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS00520
gene id: 547558:MMAH_RS00520
uniprot id: D5E8Y3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

547558:MMAH RS05615
gene id: 547558:MMAH_RS05615
uniprot id: D5EBT0
names: Similarity
messages: Belongs to the DMRL synthase family.

547558:MMAH RS04305
gene id: 547558:MMAH_RS04305
uniprot id: D5EB23
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

547558:MMAH RS05910
gene id: 547558:MMAH_RS05910
uniprot id: D5EBY6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

547558:MMAH RS03040
gene id: 547558:MMAH_RS03040
uniprot id: D5EAC8
names: Similarity
messages: Belongs to the GARS family.

547558:MMAH RS06415
gene id: 547558:MMAH_RS06415
uniprot id: D5E6K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS00720
gene id: 547558:MMAH_RS00720
uniprot id: D5E929
names: Similarity
messages: Belongs to the TPP enzyme family.

547558:MMAH RS07860
gene id: 547558:MMAH_RS07860
uniprot id: D5E7D6
names: Function
messages: Part of a potassium transport system.

547558:MMAH RS06745
gene id: 547558:MMAH_RS06745
uniprot id: D5E6R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS03250
gene id: 547558:MMAH_RS03250
uniprot id: D5EAH0
names: Similarity
messages: Belongs to the HerA family.

547558:MMAH RS04705
gene id: 547558:MMAH_RS04705
uniprot id: D5EBA3
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

547558:MMAH RS09745
gene id: 547558:MMAH_RS09745
uniprot id: D5E8F4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

547558:MMAH RS03265
gene id: 547558:MMAH_RS03265
uniprot id: D5EAH3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

547558:MMAH RS06905
gene id: 547558:MMAH_RS06905
uniprot id: D5E6U8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

547558:MMAH RS07825
gene id: 547558:MMAH_RS07825
uniprot id: D5E7C9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS05520
gene id: 547558:MMAH_RS05520
uniprot id: D5EBQ8
names: Similarity
messages: Belongs to the UPF0282 family.

547558:MMAH RS04285
gene id: 547558:MMAH_RS04285
uniprot id: D5EB19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

547558:MMAH RS09785
gene id: 547558:MMAH_RS09785
uniprot id: D5E8G2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07670
gene id: 547558:MMAH_RS07670
uniprot id: D5E7A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

547558:MMAH RS06595
gene id: 547558:MMAH_RS06595
uniprot id: D5E6N7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

547558:MMAH RS07765
gene id: 547558:MMAH_RS07765
uniprot id: D5E7B7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03085
gene id: 547558:MMAH_RS03085
uniprot id: D5EAD7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

547558:MMAH RS08610
gene id: 547558:MMAH_RS08610
uniprot id: D5E7T5
names: Similarity
messages: Belongs to the UPF0166 family.

547558:MMAH RS08435
gene id: 547558:MMAH_RS08435
uniprot id: D5E7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

547558:MMAH RS02565
gene id: 547558:MMAH_RS02565
uniprot id: D5EA41
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06295
gene id: 547558:MMAH_RS06295
uniprot id: D5EC64
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

547558:MMAH RS00640
gene id: 547558:MMAH_RS00640
uniprot id: D5E914
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

547558:MMAH RS05495
gene id: 547558:MMAH_RS05495
uniprot id: D5EBQ3
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

547558:MMAH RS02060
gene id: 547558:MMAH_RS02060
uniprot id: D5E9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

547558:MMAH RS08440
gene id: 547558:MMAH_RS08440
uniprot id: D5E7Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

547558:MMAH RS01320
gene id: 547558:MMAH_RS01320
uniprot id: D5E9F0
names: Similarity
messages: Belongs to the DtxR/MntR family.

547558:MMAH RS06795
gene id: 547558:MMAH_RS06795
uniprot id: D5E6S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS00945
gene id: 547558:MMAH_RS00945
uniprot id: D5E974
names: Similarity
messages: Belongs to the AAA ATPase family.

547558:MMAH RS02860
gene id: 547558:MMAH_RS02860
uniprot id: D5EA92
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

547558:MMAH RS03930
gene id: 547558:MMAH_RS03930
uniprot id: D5EAU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

547558:MMAH RS08035
gene id: 547558:MMAH_RS08035
uniprot id: D5E7H1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

547558:MMAH RS01855
gene id: 547558:MMAH_RS01855
uniprot id: D5E9Q8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06780
gene id: 547558:MMAH_RS06780
uniprot id: D5E6S3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

547558:MMAH RS06770
gene id: 547558:MMAH_RS06770
uniprot id: D5E6S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS06260
gene id: 547558:MMAH_RS06260
uniprot id: D5EC56
names: Similarity
messages: Belongs to the UPF0280 family.

547558:MMAH RS01495
gene id: 547558:MMAH_RS01495
uniprot id: D5E9I5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

547558:MMAH RS08805
gene id: 547558:MMAH_RS08805
uniprot id: D5E7X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

547558:MMAH RS03060
gene id: 547558:MMAH_RS03060
uniprot id: D5EAD2
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

547558:MMAH RS00930
gene id: 547558:MMAH_RS00930
uniprot id: D5E971
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

547558:MMAH RS02655
gene id: 547558:MMAH_RS02655
uniprot id: D5EA58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

547558:MMAH RS06495
gene id: 547558:MMAH_RS06495
uniprot id: D5E6M0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS10140
gene id: 547558:MMAH_RS10140
uniprot id: D5E8M8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

547558:MMAH RS10130
gene id: 547558:MMAH_RS10130
uniprot id: D5E8M7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS08585
gene id: 547558:MMAH_RS08585
uniprot id: D5E7T1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS00175
gene id: 547558:MMAH_RS00175
uniprot id: D5E8R4
names: Similarity
messages: Belongs to the peptidase M24B family.

547558:MMAH RS01770
gene id: 547558:MMAH_RS01770
uniprot id: D5E9P0
names: Similarity
messages: Belongs to the oxoprolinase family.

547558:MMAH RS04700
gene id: 547558:MMAH_RS04700
uniprot id: D5EBA2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

547558:MMAH RS10115
gene id: 547558:MMAH_RS10115
uniprot id: D5E8M4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

547558:MMAH RS09580
gene id: 547558:MMAH_RS09580
uniprot id: D5E8C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

547558:MMAH RS02355
gene id: 547558:MMAH_RS02355
uniprot id: D5EA03
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

547558:MMAH RS07680
gene id: 547558:MMAH_RS07680
uniprot id: D5E7A3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS09660
gene id: 547558:MMAH_RS09660
uniprot id: D5E8E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

547558:MMAH RS03745
gene id: 547558:MMAH_RS03745
uniprot id: D5EAR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS08830
gene id: 547558:MMAH_RS08830
uniprot id: D5E7X8
names: Similarity
messages: Belongs to the UPF0107 family.

547558:MMAH RS04045
gene id: 547558:MMAH_RS04045
uniprot id: D5EAX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS06225
gene id: 547558:MMAH_RS06225
uniprot id: D5EC50
names: Similarity
messages: Belongs to the peptidase C56 family.

547558:MMAH RS04960
gene id: 547558:MMAH_RS04960
uniprot id: D5EBF5
names: Similarity
messages: Belongs to the UPF0210 family.

547558:MMAH RS01720
gene id: 547558:MMAH_RS01720
uniprot id: D5E9N0
names: Similarity
messages: Belongs to the UPF0200 family.

547558:MMAH RS10085
gene id: 547558:MMAH_RS10085
uniprot id: D5E8L8
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS07705
gene id: 547558:MMAH_RS07705
uniprot id: D5E7A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS02665
gene id: 547558:MMAH_RS02665
uniprot id: D5EA60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

547558:MMAH RS10095
gene id: 547558:MMAH_RS10095
uniprot id: D5E8M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

547558:MMAH RS02770
gene id: 547558:MMAH_RS02770
uniprot id: D5EA74
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

547558:MMAH RS07185
gene id: 547558:MMAH_RS07185
uniprot id: D5E707
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

547558:MMAH RS06340
gene id: 547558:MMAH_RS06340
uniprot id: D5E6I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

547558:MMAH RS01825
gene id: 547558:MMAH_RS01825
uniprot id: D5E9Q1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

547558:MMAH RS08025
gene id: 547558:MMAH_RS08025
uniprot id: D5E7G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

547558:MMAH RS01835
gene id: 547558:MMAH_RS01835
uniprot id: D5E9Q3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06345
gene id: 547558:MMAH_RS06345
uniprot id: D5E6I8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

547558:MMAH RS01530
gene id: 547558:MMAH_RS01530
uniprot id: D5E9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

547558:MMAH RS01915
gene id: 547558:MMAH_RS01915
uniprot id: D5E9R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

547558:MMAH RS06330
gene id: 547558:MMAH_RS06330
uniprot id: D5E6I5
names: Similarity
messages: Belongs to the FwdC/FmdC family.

547558:MMAH RS07820
gene id: 547558:MMAH_RS07820
uniprot id: D5E7C8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

547558:MMAH RS07500
gene id: 547558:MMAH_RS07500
uniprot id: D5E767
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

547558:MMAH RS03245
gene id: 547558:MMAH_RS03245
uniprot id: D5EAG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

547558:MMAH RS09060
gene id: 547558:MMAH_RS09060
uniprot id: D5E822
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06610
gene id: 547558:MMAH_RS06610
uniprot id: D5E6P0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

547558:MMAH RS06090
gene id: 547558:MMAH_RS06090
uniprot id: D5EC23
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

547558:MMAH RS00985
gene id: 547558:MMAH_RS00985
uniprot id: D5E981
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

547558:MMAH RS09505
gene id: 547558:MMAH_RS09505
uniprot id: D5E8B1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS05810
gene id: 547558:MMAH_RS05810
uniprot id: D5EBW6
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

547558:MMAH RS09610
gene id: 547558:MMAH_RS09610
uniprot id: D5E8D2
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03080
gene id: 547558:MMAH_RS03080
uniprot id: D5EAD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

547558:MMAH RS09825
gene id: 547558:MMAH_RS09825
uniprot id: D5E8H0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

547558:MMAH RS08170
gene id: 547558:MMAH_RS08170
uniprot id: D5E7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

547558:MMAH RS00990
gene id: 547558:MMAH_RS00990
uniprot id: D5E982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

547558:MMAH RS06385
gene id: 547558:MMAH_RS06385
uniprot id: D5E6J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

547558:MMAH RS05925
gene id: 547558:MMAH_RS05925
uniprot id: D5EBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

547558:MMAH RS08695
gene id: 547558:MMAH_RS08695
uniprot id: D5E7V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

547558:MMAH RS02165
gene id: 547558:MMAH_RS02165
uniprot id: D5E9W6
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

547558:MMAH RS07055
gene id: 547558:MMAH_RS07055
uniprot id: D5E6X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

547558:MMAH RS02600
gene id: 547558:MMAH_RS02600
uniprot id: D5EA48
names: Similarity
messages: Belongs to the AdoMet synthase family.

547558:MMAH RS00225
gene id: 547558:MMAH_RS00225
uniprot id: D5E8S5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS09890
gene id: 547558:MMAH_RS09890
uniprot id: D5E8I3
names: Similarity
messages: Belongs to the HisA/HisF family.

547558:MMAH RS02570
gene id: 547558:MMAH_RS02570
uniprot id: D5EA42
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

547558:MMAH RS06375
gene id: 547558:MMAH_RS06375
uniprot id: D5E6J5
names: Similarity
messages: Belongs to the class-I fumarase family.

547558:MMAH RS06620
gene id: 547558:MMAH_RS06620
uniprot id: D5E6P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

547558:MMAH RS06740
gene id: 547558:MMAH_RS06740
uniprot id: D5E6R5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

547558:MMAH RS09050
gene id: 547558:MMAH_RS09050
uniprot id: D5E820
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS01035
gene id: 547558:MMAH_RS01035
uniprot id: D5E992
names: Similarity
messages: Belongs to the glutamate synthase family.

547558:MMAH RS09555
gene id: 547558:MMAH_RS09555
uniprot id: D5E8C1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS09035
gene id: 547558:MMAH_RS09035
uniprot id: D5E817
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

547558:MMAH RS08175
gene id: 547558:MMAH_RS08175
uniprot id: D5E7J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

547558:MMAH RS08600
gene id: 547558:MMAH_RS08600
uniprot id: D5E7T3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

547558:MMAH RS00250
gene id: 547558:MMAH_RS00250
uniprot id: D5E8T0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

547558:MMAH RS04300
gene id: 547558:MMAH_RS04300
uniprot id: D5EB22
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

547558:MMAH RS07645
gene id: 547558:MMAH_RS07645
uniprot id: D5E796
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

547558:MMAH RS06870
gene id: 547558:MMAH_RS06870
uniprot id: D5E6U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

547558:MMAH RS07930
gene id: 547558:MMAH_RS07930
uniprot id: D5E7F0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS01970
gene id: 547558:MMAH_RS01970
uniprot id: D5E9T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

547558:MMAH RS08285
gene id: 547558:MMAH_RS08285
uniprot id: D5E7M0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

547558:MMAH RS06800
gene id: 547558:MMAH_RS06800
uniprot id: D5E6S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

547558:MMAH RS02555
gene id: 547558:MMAH_RS02555
uniprot id: D5EA39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

547558:MMAH RS01505
gene id: 547558:MMAH_RS01505
uniprot id: D5E9I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

547558:MMAH RS05185
gene id: 547558:MMAH_RS05185
uniprot id: D5EBJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

547558:MMAH RS09605
gene id: 547558:MMAH_RS09605
uniprot id: D5E8D1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

547558:MMAH RS09625
gene id: 547558:MMAH_RS09625
uniprot id: D5E8D5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

547558:MMAH RS07695
gene id: 547558:MMAH_RS07695
uniprot id: D5E7A5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

547558:MMAH RS09300
gene id: 547558:MMAH_RS09300
uniprot id: D5E869
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

547558:MMAH RS07435
gene id: 547558:MMAH_RS07435
uniprot id: D5E754
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

547558:MMAH RS05805
gene id: 547558:MMAH_RS05805
uniprot id: D5EBW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS04010
gene id: 547558:MMAH_RS04010
uniprot id: D5EAW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

547558:MMAH RS08005
gene id: 547558:MMAH_RS08005
uniprot id: D5E7G5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

547558:MMAH RS01800
gene id: 547558:MMAH_RS01800
uniprot id: D5E9P6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

547558:MMAH RS08290
gene id: 547558:MMAH_RS08290
uniprot id: D5E7M1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS04965
gene id: 547558:MMAH_RS04965
uniprot id: D5EBF6
names: Similarity
messages: Belongs to the UPF0237 family.

547558:MMAH RS07890
gene id: 547558:MMAH_RS07890
uniprot id: D5E7E2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

547558:MMAH RS05680
gene id: 547558:MMAH_RS05680
uniprot id: D5EBU2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS08540
gene id: 547558:MMAH_RS08540
uniprot id: D5E7S0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS07315
gene id: 547558:MMAH_RS07315
uniprot id: D5E733
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS00140
gene id: 547558:MMAH_RS00140
uniprot id: D5E8Q7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS04930
gene id: 547558:MMAH_RS04930
uniprot id: D5EBE9
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS08865
gene id: 547558:MMAH_RS08865
uniprot id: D5E7Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS07465
gene id: 547558:MMAH_RS07465
uniprot id: D5E760
names: Subcellular Location Annotation
messages: Cell membrane

547558:MMAH RS04145
gene id: 547558:MMAH_RS04145
uniprot id: D5EAZ3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS08790
gene id: 547558:MMAH_RS08790
uniprot id: D5E7X0
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

547558:MMAH RS07070
gene id: 547558:MMAH_RS07070
uniprot id: D5E6Y1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

547558:MMAH RS05840
gene id: 547558:MMAH_RS05840
uniprot id: D5EBX2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

547558:MMAH RS03555
gene id: 547558:MMAH_RS03555
uniprot id: D5EAM8
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

547558:MMAH RS00030
gene id: 547558:MMAH_RS00030
uniprot id: D5E8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

547558:MMAH RS06130
gene id: 547558:MMAH_RS06130
uniprot id: D5EC31
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

547558:MMAH RS01785
gene id: 547558:MMAH_RS01785
uniprot id: D5E9P3
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

547558:MMAH RS06110
gene id: 547558:MMAH_RS06110
uniprot id: D5EC27
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

547558:MMAH RS05890
gene id: 547558:MMAH_RS05890
uniprot id: D5EBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

547558:MMAH RS04905
gene id: 547558:MMAH_RS04905
uniprot id: D5EBE4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS02685
gene id: 547558:MMAH_RS02685
uniprot id: D5EA64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

547558:MMAH RS01945
gene id: 547558:MMAH_RS01945
uniprot id: D5E9S5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

547558:MMAH RS06735
gene id: 547558:MMAH_RS06735
uniprot id: D5E6R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

547558:MMAH RS01460
gene id: 547558:MMAH_RS01460
uniprot id: D5E9H9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS03100
gene id: 547558:MMAH_RS03100
uniprot id: D5EAE0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

547558:MMAH RS07975
gene id: 547558:MMAH_RS07975
uniprot id: D5E7F9
names: Similarity
messages: Belongs to the complex I subunit 3 family.

547558:MMAH RS02980
gene id: 547558:MMAH_RS02980
uniprot id: D5EAB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

547558:MMAH RS03530
gene id: 547558:MMAH_RS03530
uniprot id: D5EAM2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06655
gene id: 547558:MMAH_RS06655
uniprot id: D5E6P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

547558:MMAH RS04000
gene id: 547558:MMAH_RS04000
uniprot id: D5EAW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

547558:MMAH RS06960
gene id: 547558:MMAH_RS06960
uniprot id: D5E6V9
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

547558:MMAH RS06025
gene id: 547558:MMAH_RS06025
uniprot id: D5EC10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

547558:MMAH RS07400
gene id: 547558:MMAH_RS07400
uniprot id: D5E747
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

547558:MMAH RS04030
gene id: 547558:MMAH_RS04030
uniprot id: D5EAW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

547558:MMAH RS01155
gene id: 547558:MMAH_RS01155
uniprot id: D5E9B6
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

547558:MMAH RS07190
gene id: 547558:MMAH_RS07190
uniprot id: D5E708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

547558:MMAH RS09815
gene id: 547558:MMAH_RS09815
uniprot id: D5E8G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS04760
gene id: 547558:MMAH_RS04760
uniprot id: D5EBB4
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02975
gene id: 547558:MMAH_RS02975
uniprot id: D5EAB6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

547558:MMAH RS04925
gene id: 547558:MMAH_RS04925
uniprot id: D5EBE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

547558:MMAH RS04165
gene id: 547558:MMAH_RS04165
uniprot id: D5EAZ7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06755
gene id: 547558:MMAH_RS06755
uniprot id: D5E6R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS01135
gene id: 547558:MMAH_RS01135
uniprot id: D5E9B2
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

547558:MMAH RS08280
gene id: 547558:MMAH_RS08280
uniprot id: D5E7L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

547558:MMAH RS03230
gene id: 547558:MMAH_RS03230
uniprot id: D5EAG6
names: Similarity
messages: Belongs to the TlyA family.

547558:MMAH RS01510
gene id: 547558:MMAH_RS01510
uniprot id: D5E9I8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

547558:MMAH RS08045
gene id: 547558:MMAH_RS08045
uniprot id: D5E7H3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

547558:MMAH RS09840
gene id: 547558:MMAH_RS09840
uniprot id: D5E8H3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

547558:MMAH RS06180
gene id: 547558:MMAH_RS06180
uniprot id: D5EC41
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07290
gene id: 547558:MMAH_RS07290
uniprot id: D5E728
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

547558:MMAH RS00025
gene id: 547558:MMAH_RS00025
uniprot id: D5E8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

547558:MMAH RS09015
gene id: 547558:MMAH_RS09015
uniprot id: D5E813
names: Similarity
messages: Belongs to the archaeal-type GPI family.

547558:MMAH RS08785
gene id: 547558:MMAH_RS08785
uniprot id: D5E7W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS02810
gene id: 547558:MMAH_RS02810
uniprot id: D5EA82
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

547558:MMAH RS06910
gene id: 547558:MMAH_RS06910
uniprot id: D5E6U9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

547558:MMAH RS06490
gene id: 547558:MMAH_RS06490
uniprot id: D5E6L8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

547558:MMAH RS09485
gene id: 547558:MMAH_RS09485
uniprot id: D5E8A7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS07870
gene id: 547558:MMAH_RS07870
uniprot id: D5E7D8
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

547558:MMAH RS06065
gene id: 547558:MMAH_RS06065
uniprot id: D5EC18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

547558:MMAH RS10120
gene id: 547558:MMAH_RS10120
uniprot id: D5E8M5
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS09765
gene id: 547558:MMAH_RS09765
uniprot id: D5E8F8
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

547558:MMAH RS09425
gene id: 547558:MMAH_RS09425
uniprot id: D5E894
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS02585
gene id: 547558:MMAH_RS02585
uniprot id: D5EA45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

547558:MMAH RS06360
gene id: 547558:MMAH_RS06360
uniprot id: D5E6J1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

547558:MMAH RS04225
gene id: 547558:MMAH_RS04225
uniprot id: D5EB09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

547558:MMAH RS05335
gene id: 547558:MMAH_RS05335
uniprot id: D5EBM3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS01990
gene id: 547558:MMAH_RS01990
uniprot id: D5E9T4
names: Similarity
messages: Belongs to the MtrH family.

547558:MMAH RS08300
gene id: 547558:MMAH_RS08300
uniprot id: D5E7M3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS09445
gene id: 547558:MMAH_RS09445
uniprot id: D5E898
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS04025
gene id: 547558:MMAH_RS04025
uniprot id: D5EAW6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

547558:MMAH RS02525
gene id: 547558:MMAH_RS02525
uniprot id: D5EA33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

547558:MMAH RS02475
gene id: 547558:MMAH_RS02475
uniprot id: D5EA25
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS03730
gene id: 547558:MMAH_RS03730
uniprot id: D5EAR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS04845
gene id: 547558:MMAH_RS04845
uniprot id: D5EBD1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03685
gene id: 547558:MMAH_RS03685
uniprot id: D5EAQ3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS01780
gene id: 547558:MMAH_RS01780
uniprot id: D5E9P2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

547558:MMAH RS01325
gene id: 547558:MMAH_RS01325
uniprot id: D5E9F1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02830
gene id: 547558:MMAH_RS02830
uniprot id: D5EA86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

547558:MMAH RS07745
gene id: 547558:MMAH_RS07745
uniprot id: D5E7B5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

547558:MMAH RS00925
gene id: 547558:MMAH_RS00925
uniprot id: D5E970
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

547558:MMAH RS02425
gene id: 547558:MMAH_RS02425
uniprot id: D5EA15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

547558:MMAH RS10145
gene id: 547558:MMAH_RS10145
uniprot id: D5E8M9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS03090
gene id: 547558:MMAH_RS03090
uniprot id: D5EAD8
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

547558:MMAH RS01120
gene id: 547558:MMAH_RS01120
uniprot id: D5E9A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

547558:MMAH RS08870
gene id: 547558:MMAH_RS08870
uniprot id: D5E7Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS08670
gene id: 547558:MMAH_RS08670
uniprot id: D5E7U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS01225
gene id: 547558:MMAH_RS01225
uniprot id: D5E9C9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

547558:MMAH RS09975
gene id: 547558:MMAH_RS09975
uniprot id: D5E8J9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

547558:MMAH RS04750
gene id: 547558:MMAH_RS04750
uniprot id: D5EBB2
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS05985
gene id: 547558:MMAH_RS05985
uniprot id: D5EC02
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

547558:MMAH RS03110
gene id: 547558:MMAH_RS03110
uniprot id: D5EAE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

547558:MMAH RS09495
gene id: 547558:MMAH_RS09495
uniprot id: D5E8A9
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS05830
gene id: 547558:MMAH_RS05830
uniprot id: D5EBX0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

547558:MMAH RS02660
gene id: 547558:MMAH_RS02660
uniprot id: D5EA59
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

547558:MMAH RS07030
gene id: 547558:MMAH_RS07030
uniprot id: D5E6X3
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

547558:MMAH RS04035
gene id: 547558:MMAH_RS04035
uniprot id: D5EAW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

547558:MMAH RS01920
gene id: 547558:MMAH_RS01920
uniprot id: D5E9S0
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

547558:MMAH RS06310
gene id: 547558:MMAH_RS06310
uniprot id: D5E6I1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06220
gene id: 547558:MMAH_RS06220
uniprot id: D5EC48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

547558:MMAH RS06775
gene id: 547558:MMAH_RS06775
uniprot id: D5E6S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

547558:MMAH RS01005
gene id: 547558:MMAH_RS01005
uniprot id: D5E985
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02340
gene id: 547558:MMAH_RS02340
uniprot id: D5EA00
names: Similarity
messages: Belongs to the peptidase C56 family.

547558:MMAH RS07175
gene id: 547558:MMAH_RS07175
uniprot id: D5E705
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

547558:MMAH RS02835
gene id: 547558:MMAH_RS02835
uniprot id: D5EA87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

547558:MMAH RS03950
gene id: 547558:MMAH_RS03950
uniprot id: D5EAV2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07650
gene id: 547558:MMAH_RS07650
uniprot id: D5E797
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

547558:MMAH RS05390
gene id: 547558:MMAH_RS05390
uniprot id: D5EBN2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

547558:MMAH RS08570
gene id: 547558:MMAH_RS08570
uniprot id: D5E7S8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS01185
gene id: 547558:MMAH_RS01185
uniprot id: D5E9C2
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

547558:MMAH RS09025
gene id: 547558:MMAH_RS09025
uniprot id: D5E815
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

547558:MMAH RS03550
gene id: 547558:MMAH_RS03550
uniprot id: D5EAM7
names: Function
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

547558:MMAH RS01190
gene id: 547558:MMAH_RS01190
uniprot id: D5E9C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

547558:MMAH RS04290
gene id: 547558:MMAH_RS04290
uniprot id: D5EB20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

547558:MMAH RS06720
gene id: 547558:MMAH_RS06720
uniprot id: D5E6R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

547558:MMAH RS08160
gene id: 547558:MMAH_RS08160
uniprot id: D5E7J4
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

547558:MMAH RS08545
gene id: 547558:MMAH_RS08545
uniprot id: D5E7S1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS05470
gene id: 547558:MMAH_RS05470
uniprot id: D5EBP8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

547558:MMAH RS04840
gene id: 547558:MMAH_RS04840
uniprot id: D5EBD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS03740
gene id: 547558:MMAH_RS03740
uniprot id: D5EAR3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02215
gene id: 547558:MMAH_RS02215
uniprot id: D5E9X7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02510
gene id: 547558:MMAH_RS02510
uniprot id: D5EA30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

547558:MMAH RS07150
gene id: 547558:MMAH_RS07150
uniprot id: D5E6Z9
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

547558:MMAH RS01050
gene id: 547558:MMAH_RS01050
uniprot id: D5E995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS01810
gene id: 547558:MMAH_RS01810
uniprot id: D5E9P8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

547558:MMAH RS01860
gene id: 547558:MMAH_RS01860
uniprot id: D5E9Q9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

547558:MMAH RS04810
gene id: 547558:MMAH_RS04810
uniprot id: D5EBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

547558:MMAH RS05950
gene id: 547558:MMAH_RS05950
uniprot id: D5EBZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS00585
gene id: 547558:MMAH_RS00585
uniprot id: D5E903
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

547558:MMAH RS09595
gene id: 547558:MMAH_RS09595
uniprot id: D5E8C9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

547558:MMAH RS01085
gene id: 547558:MMAH_RS01085
uniprot id: D5E9A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

547558:MMAH RS09210
gene id: 547558:MMAH_RS09210
uniprot id: D5E851
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

547558:MMAH RS02535
gene id: 547558:MMAH_RS02535
uniprot id: D5EA35
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

547558:MMAH RS06730
gene id: 547558:MMAH_RS06730
uniprot id: D5E6R3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS02190
gene id: 547558:MMAH_RS02190
uniprot id: D5E9X1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

547558:MMAH RS09620
gene id: 547558:MMAH_RS09620
uniprot id: D5E8D4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

547558:MMAH RS01280
gene id: 547558:MMAH_RS01280
uniprot id: D5E9E1
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

547558:MMAH RS04260
gene id: 547558:MMAH_RS04260
uniprot id: D5EB16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

547558:MMAH RS07285
gene id: 547558:MMAH_RS07285
uniprot id: D5E727
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

547558:MMAH RS06055
gene id: 547558:MMAH_RS06055
uniprot id: D5EC16
names: Similarity
messages: Belongs to the PDCD5 family.

547558:MMAH RS07725
gene id: 547558:MMAH_RS07725
uniprot id: D5E7B1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

547558:MMAH RS08405
gene id: 547558:MMAH_RS08405
uniprot id: D5E7P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

547558:MMAH RS06765
gene id: 547558:MMAH_RS06765
uniprot id: D5E6S0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

547558:MMAH RS09645
gene id: 547558:MMAH_RS09645
uniprot id: D5E8D9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS05995
gene id: 547558:MMAH_RS05995
uniprot id: D5EC04
names: Subcellular Location Annotation
messages: Cytoplasm

547558:MMAH RS06845
gene id: 547558:MMAH_RS06845
uniprot id: D5E6T6
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS00885
gene id: 547558:MMAH_RS00885
uniprot id: D5E962
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

547558:MMAH RS04640
gene id: 547558:MMAH_RS04640
uniprot id: D5EB91
names: Similarity
messages: Belongs to the pyruvate kinase family.

547558:MMAH RS06080
gene id: 547558:MMAH_RS06080
uniprot id: D5EC21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

547558:MMAH RS05590
gene id: 547558:MMAH_RS05590
uniprot id: D5EBS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

547558:MMAH RS00385
gene id: 547558:MMAH_RS00385
uniprot id: D5E8V6
names: Similarity
messages: Belongs to the peptidase C1 family.

547558:MMAH RS00915
gene id: 547558:MMAH_RS00915
uniprot id: D5E968
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

547558:MMAH RS08450
gene id: 547558:MMAH_RS08450
uniprot id: D5E7Q2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

547558:MMAH RS04245
gene id: 547558:MMAH_RS04245
uniprot id: D5EB13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

547558:MMAH RS04340
gene id: 547558:MMAH_RS04340
uniprot id: D5EB31
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

547558:MMAH RS06035
gene id: 547558:MMAH_RS06035
uniprot id: D5EC12
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

547558:MMAH RS05970
gene id: 547558:MMAH_RS05970
uniprot id: D5EBZ9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

547558:MMAH RS06115
gene id: 547558:MMAH_RS06115
uniprot id: D5EC28
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

547558:MMAH RS08625
gene id: 547558:MMAH_RS08625
uniprot id: D5E7T8
names: Similarity
messages: Belongs to the MoaB/Mog family.

547558:MMAH RS06690
gene id: 547558:MMAH_RS06690
uniprot id: D5E6Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS01100
gene id: 547558:MMAH_RS01100
uniprot id: D5E9A5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

547558:MMAH RS09170
gene id: 547558:MMAH_RS09170
uniprot id: D5E844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS01880
gene id: 547558:MMAH_RS01880
uniprot id: D5E9R3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

547558:MMAH RS02945
gene id: 547558:MMAH_RS02945
uniprot id: D5EAB0
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

547558:MMAH RS03410
gene id: 547558:MMAH_RS03410
uniprot id: D5EAJ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

547558:MMAH RS09380
gene id: 547558:MMAH_RS09380
uniprot id: D5E885
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS05610
gene id: 547558:MMAH_RS05610
uniprot id: D5EBS9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

547558:MMAH RS07450
gene id: 547558:MMAH_RS07450
uniprot id: D5E757
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS05150
gene id: 547558:MMAH_RS05150
uniprot id: D5EBJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

547558:MMAH RS08495
gene id: 547558:MMAH_RS08495
uniprot id: D5E7R1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS09980
gene id: 547558:MMAH_RS09980
uniprot id: D5E8K0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06125
gene id: 547558:MMAH_RS06125
uniprot id: D5EC30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

547558:MMAH RS07575
gene id: 547558:MMAH_RS07575
uniprot id: D5E782
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

547558:MMAH RS01950
gene id: 547558:MMAH_RS01950
uniprot id: D5E9S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

547558:MMAH RS07165
gene id: 547558:MMAH_RS07165
uniprot id: D5E703
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

547558:MMAH RS08010
gene id: 547558:MMAH_RS08010
uniprot id: D5E7G6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

547558:MMAH RS04500
gene id: 547558:MMAH_RS04500
uniprot id: D5EB64
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

547558:MMAH RS02855
gene id: 547558:MMAH_RS02855
uniprot id: D5EA91
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

547558:MMAH RS01540
gene id: 547558:MMAH_RS01540
uniprot id: D5E9J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

547558:MMAH RS02245
gene id: 547558:MMAH_RS02245
uniprot id: D5E9Y2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

547558:MMAH RS04020
gene id: 547558:MMAH_RS04020
uniprot id: D5EAW5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

547558:MMAH RS04085
gene id: 547558:MMAH_RS04085
uniprot id: D5EAY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS01975
gene id: 547558:MMAH_RS01975
uniprot id: D5E9T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

547558:MMAH RS00905
gene id: 547558:MMAH_RS00905
uniprot id: D5E966
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

547558:MMAH RS00115
gene id: 547558:MMAH_RS00115
uniprot id: D5E8Q2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

547558:MMAH RS01635
gene id: 547558:MMAH_RS01635
uniprot id: D5E9L3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

547558:MMAH RS05105
gene id: 547558:MMAH_RS05105
uniprot id: D5EBI2
names: Similarity
messages: Belongs to the peptidase S8 family.

547558:MMAH RS06725
gene id: 547558:MMAH_RS06725
uniprot id: D5E6R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS02895
gene id: 547558:MMAH_RS02895
uniprot id: D5EAA0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

547558:MMAH RS08215
gene id: 547558:MMAH_RS08215
uniprot id: D5E7K5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

547558:MMAH RS04220
gene id: 547558:MMAH_RS04220
uniprot id: D5EB08
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06365
gene id: 547558:MMAH_RS06365
uniprot id: D5E6J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

547558:MMAH RS03820
gene id: 547558:MMAH_RS03820
uniprot id: D5EAS6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

547558:MMAH RS03465
gene id: 547558:MMAH_RS03465
uniprot id: D5EAK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

547558:MMAH RS08030
gene id: 547558:MMAH_RS08030
uniprot id: D5E7H0
names: Similarity
messages: Belongs to the CutA family.

547558:MMAH RS05685
gene id: 547558:MMAH_RS05685
uniprot id: D5EBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

547558:MMAH RS08885
gene id: 547558:MMAH_RS08885
uniprot id: D5E7Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS08345
gene id: 547558:MMAH_RS08345
uniprot id: D5E7N2
names: Function
messages: Part of a potassium transport system.

547558:MMAH RS00215
gene id: 547558:MMAH_RS00215
uniprot id: D5E8S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS00680
gene id: 547558:MMAH_RS00680
uniprot id: D5E921
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

547558:MMAH RS09270
gene id: 547558:MMAH_RS09270
uniprot id: D5E863
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS03960
gene id: 547558:MMAH_RS03960
uniprot id: D5EAV4
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

547558:MMAH RS00770
gene id: 547558:MMAH_RS00770
uniprot id: D5E939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS08270
gene id: 547558:MMAH_RS08270
uniprot id: D5E7L7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

547558:MMAH RS01260
gene id: 547558:MMAH_RS01260
uniprot id: D5E9D6
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS09820
gene id: 547558:MMAH_RS09820
uniprot id: D5E8G9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

547558:MMAH RS02670
gene id: 547558:MMAH_RS02670
uniprot id: D5EA61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

547558:MMAH RS10105
gene id: 547558:MMAH_RS10105
uniprot id: D5E8M2
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

547558:MMAH RS07525
gene id: 547558:MMAH_RS07525
uniprot id: D5E772
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

547558:MMAH RS05865
gene id: 547558:MMAH_RS05865
uniprot id: D5EBX7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07245
gene id: 547558:MMAH_RS07245
uniprot id: D5E719
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

547558:MMAH RS00265
gene id: 547558:MMAH_RS00265
uniprot id: D5E8T3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

547558:MMAH RS03075
gene id: 547558:MMAH_RS03075
uniprot id: D5EAD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

547558:MMAH RS00995
gene id: 547558:MMAH_RS00995
uniprot id: D5E983
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

547558:MMAH RS02445
gene id: 547558:MMAH_RS02445
uniprot id: D5EA19
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

547558:MMAH RS07445
gene id: 547558:MMAH_RS07445
uniprot id: D5E756
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS01900
gene id: 547558:MMAH_RS01900
uniprot id: D5E9R6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

547558:MMAH RS03850
gene id: 547558:MMAH_RS03850
uniprot id: D5EAT3
names: Subcellular Location Annotation
messages: Cell membrane

547558:MMAH RS02440
gene id: 547558:MMAH_RS02440
uniprot id: D5EA18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

547558:MMAH RS06020
gene id: 547558:MMAH_RS06020
uniprot id: D5EC09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

547558:MMAH RS09880
gene id: 547558:MMAH_RS09880
uniprot id: D5E8I1
names: Similarity
messages: Belongs to the thymidylate kinase family.

547558:MMAH RS01045
gene id: 547558:MMAH_RS01045
uniprot id: D5E994
names: Similarity
messages: Belongs to the P(II) protein family.

547558:MMAH RS03985
gene id: 547558:MMAH_RS03985
uniprot id: D5EAV8
names: Similarity
messages: Belongs to the ZPR1 family.

547558:MMAH RS01105
gene id: 547558:MMAH_RS01105
uniprot id: D5E9A6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

547558:MMAH RS05835
gene id: 547558:MMAH_RS05835
uniprot id: D5EBX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

547558:MMAH RS00705
gene id: 547558:MMAH_RS00705
uniprot id: D5E926
names: Similarity
messages: Belongs to the PurH family.

547558:MMAH RS09995
gene id: 547558:MMAH_RS09995
uniprot id: D5E8K2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06040
gene id: 547558:MMAH_RS06040
uniprot id: D5EC13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

547558:MMAH RS04080
gene id: 547558:MMAH_RS04080
uniprot id: D5EAX9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

547558:MMAH RS06005
gene id: 547558:MMAH_RS06005
uniprot id: D5EC06
names: Similarity
messages: Belongs to the TrpC family.

547558:MMAH RS03440
gene id: 547558:MMAH_RS03440
uniprot id: D5EAK3
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

547558:MMAH RS05960
gene id: 547558:MMAH_RS05960
uniprot id: D5EBZ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

547558:MMAH RS09705
gene id: 547558:MMAH_RS09705
uniprot id: D5E8E6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS02780
gene id: 547558:MMAH_RS02780
uniprot id: D5EA76
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

547558:MMAH RS02845
gene id: 547558:MMAH_RS02845
uniprot id: D5EA89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

547558:MMAH RS03160
gene id: 547558:MMAH_RS03160
uniprot id: D5EAF2
names: Similarity
messages: Belongs to the MCM family.

547558:MMAH RS00850
gene id: 547558:MMAH_RS00850
uniprot id: D5E954
names: Similarity
messages: Belongs to the peptidase S49 family.

547558:MMAH RS05775
gene id: 547558:MMAH_RS05775
uniprot id: D5EBU2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS01160
gene id: 547558:MMAH_RS01160
uniprot id: D5E9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

547558:MMAH RS08485
gene id: 547558:MMAH_RS08485
uniprot id: D5E7Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

547558:MMAH RS07710
gene id: 547558:MMAH_RS07710
uniprot id: D5E7A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

547558:MMAH RS00005
gene id: 547558:MMAH_RS00005
uniprot id: D5E8N0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

547558:MMAH RS01390
gene id: 547558:MMAH_RS01390
uniprot id: D5E9G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

547558:MMAH RS05850
gene id: 547558:MMAH_RS05850
uniprot id: D5EBX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

547558:MMAH RS03475
gene id: 547558:MMAH_RS03475
uniprot id: D5EAL1
names: Similarity
messages: Belongs to the UPF0147 family.

547558:MMAH RS03590
gene id: 547558:MMAH_RS03590
uniprot id: D5EAN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

547558:MMAH RS05715
gene id: 547558:MMAH_RS05715
uniprot id: D5EBU9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

547558:MMAH RS08225
gene id: 547558:MMAH_RS08225
uniprot id: D5E7K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

547558:MMAH RS00670
gene id: 547558:MMAH_RS00670
uniprot id: D5E919
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

547558:MMAH RS01435
gene id: 547558:MMAH_RS01435
uniprot id: D5E9H3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS03240
gene id: 547558:MMAH_RS03240
uniprot id: D5EAG8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

547558:MMAH RS09955
gene id: 547558:MMAH_RS09955
uniprot id: D5E8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

547558:MMAH RS08955
gene id: 547558:MMAH_RS08955
uniprot id: D5E803
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

547558:MMAH RS00255
gene id: 547558:MMAH_RS00255
uniprot id: D5E8T1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS05695
gene id: 547558:MMAH_RS05695
uniprot id: D5EBU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

547558:MMAH RS07345
gene id: 547558:MMAH_RS07345
uniprot id: D5E738
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

547558:MMAH RS08505
gene id: 547558:MMAH_RS08505
uniprot id: D5E7R3
names: Similarity
messages: Belongs to the eIF-2-alpha family.

547558:MMAH RS09335
gene id: 547558:MMAH_RS09335
uniprot id: D5E876
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

547558:MMAH RS06700
gene id: 547558:MMAH_RS06700
uniprot id: D5E6Q7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

547558:MMAH RS07550
gene id: 547558:MMAH_RS07550
uniprot id: D5E777
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

547558:MMAH RS10110
gene id: 547558:MMAH_RS10110
uniprot id: D5E8M3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

547558:MMAH RS09165
gene id: 547558:MMAH_RS09165
uniprot id: D5E843
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS07675
gene id: 547558:MMAH_RS07675
uniprot id: D5E7A2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

547558:MMAH RS03725
gene id: 547558:MMAH_RS03725
uniprot id: D5EAR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS03355
gene id: 547558:MMAH_RS03355
uniprot id: D5EAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

547558:MMAH RS10090
gene id: 547558:MMAH_RS10090
uniprot id: D5E8L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

547558:MMAH RS02455
gene id: 547558:MMAH_RS02455
uniprot id: D5EA21
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS07255
gene id: 547558:MMAH_RS07255
uniprot id: D5E721
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

547558:MMAH RS06670
gene id: 547558:MMAH_RS06670
uniprot id: D5E6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

547558:MMAH RS05260
gene id: 547558:MMAH_RS05260
uniprot id: D5EBK9
names: Similarity
messages: Belongs to the HsdR family.

547558:MMAH RS07160
gene id: 547558:MMAH_RS07160
uniprot id: D5E702
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

547558:MMAH RS01665
gene id: 547558:MMAH_RS01665
uniprot id: D5E9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

547558:MMAH RS09195
gene id: 547558:MMAH_RS09195
uniprot id: D5E848
names: Similarity
messages: Belongs to the thioesterase PaaI family.

547558:MMAH RS06955
gene id: 547558:MMAH_RS06955
uniprot id: D5E6V8
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS08415
gene id: 547558:MMAH_RS08415
uniprot id: D5E7P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

547558:MMAH RS08915
gene id: 547558:MMAH_RS08915
uniprot id: D5E7Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

547558:MMAH RS00895
gene id: 547558:MMAH_RS00895
uniprot id: D5E964
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

547558:MMAH RS01795
gene id: 547558:MMAH_RS01795
uniprot id: D5E9P5
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

547558:MMAH RS09265
gene id: 547558:MMAH_RS09265
uniprot id: D5E862
names: Similarity
messages: Belongs to the UPF0288 family.

547558:MMAH RS00245
gene id: 547558:MMAH_RS00245
uniprot id: D5E8S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

547558:MMAH RS07520
gene id: 547558:MMAH_RS07520
uniprot id: D5E771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

547558:MMAH RS09020
gene id: 547558:MMAH_RS09020
uniprot id: D5E814
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

547558:MMAH RS09440
gene id: 547558:MMAH_RS09440
uniprot id: D5E897
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

547558:MMAH RS03415
gene id: 547558:MMAH_RS03415
uniprot id: D5EAJ8
names: Subcellular Location Annotation
messages: Cell membrane

547558:MMAH RS01195
gene id: 547558:MMAH_RS01195
uniprot id: D5E9C4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

547558:MMAH RS01735
gene id: 547558:MMAH_RS01735
uniprot id: D5E9N3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

547558:MMAH RS04315
gene id: 547558:MMAH_RS04315
uniprot id: D5EB26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

547558:MMAH RS05935
gene id: 547558:MMAH_RS05935
uniprot id: D5EBZ2
names: Similarity
messages: Belongs to the SfsA family.

547558:MMAH RS05620
gene id: 547558:MMAH_RS05620
uniprot id: D5EBT1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

547558:MMAH RS06685
gene id: 547558:MMAH_RS06685
uniprot id: D5E6Q4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

547558:MMAH RS00130
gene id: 547558:MMAH_RS00130
uniprot id: D5E8Q5
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

547558:MMAH RS03375
gene id: 547558:MMAH_RS03375
uniprot id: D5EAJ4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

547558:MMAH RS03545
gene id: 547558:MMAH_RS03545
uniprot id: D5EAM6
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

547558:MMAH RS06235
gene id: 547558:MMAH_RS06235
uniprot id: D5EC51
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

547558:MMAH RS01450
gene id: 547558:MMAH_RS01450
uniprot id: D5E9H6
names: Similarity
messages: Belongs to the AAA ATPase family.

547558:MMAH RS03220
gene id: 547558:MMAH_RS03220
uniprot id: D5EAG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

547558:MMAH RS05630
gene id: 547558:MMAH_RS05630
uniprot id: D5EBT3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS07970
gene id: 547558:MMAH_RS07970
uniprot id: D5E7F8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

547558:MMAH RS03495
gene id: 547558:MMAH_RS03495
uniprot id: D5EAL5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS09185
gene id: 547558:MMAH_RS09185
uniprot id: D5E847
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

547558:MMAH RS09910
gene id: 547558:MMAH_RS09910
uniprot id: D5E8I7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

547558:MMAH RS04135
gene id: 547558:MMAH_RS04135
uniprot id: D5EAZ1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03570
gene id: 547558:MMAH_RS03570
uniprot id: D5EAN1
names: Similarity
messages: Belongs to the threonine synthase family.

547558:MMAH RS03660
gene id: 547558:MMAH_RS03660
uniprot id: D5EAP8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

547558:MMAH RS04180
gene id: 547558:MMAH_RS04180
uniprot id: D5EB00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS04055
gene id: 547558:MMAH_RS04055
uniprot id: D5EAX3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

547558:MMAH RS10080
gene id: 547558:MMAH_RS10080
uniprot id: D5E8L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

547558:MMAH RS04295
gene id: 547558:MMAH_RS04295
uniprot id: D5EB21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS08890
gene id: 547558:MMAH_RS08890
uniprot id: D5E7Z0
names: Similarity
messages: Belongs to the MtrH family.

547558:MMAH RS04915
gene id: 547558:MMAH_RS04915
uniprot id: D5EBE6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS06695
gene id: 547558:MMAH_RS06695
uniprot id: D5E6Q6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS08125
gene id: 547558:MMAH_RS08125
uniprot id: D5E7I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

547558:MMAH RS07015
gene id: 547558:MMAH_RS07015
uniprot id: D5E6X0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS08265
gene id: 547558:MMAH_RS08265
uniprot id: D5E7L6
names: Similarity
messages: Belongs to the FBPase class 2 family.

547558:MMAH RS05255
gene id: 547558:MMAH_RS05255
uniprot id: D5EBK8
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

547558:MMAH RS04770
gene id: 547558:MMAH_RS04770
uniprot id: D5EBB6
names: Subcellular Location Annotation
messages: Cell membrane

547558:MMAH RS00120
gene id: 547558:MMAH_RS00120
uniprot id: D5E8Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

547558:MMAH RS09985
gene id: 547558:MMAH_RS09985
uniprot id: D5E8K1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

547558:MMAH RS07845
gene id: 547558:MMAH_RS07845
uniprot id: D5E7D3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07045
gene id: 547558:MMAH_RS07045
uniprot id: D5E6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

547558:MMAH RS02095
gene id: 547558:MMAH_RS02095
uniprot id: D5E9V2
names: Subcellular Location Annotation
messages: Cytoplasm

547558:MMAH RS06030
gene id: 547558:MMAH_RS06030
uniprot id: D5EC11
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

547558:MMAH RS07925
gene id: 547558:MMAH_RS07925
uniprot id: D5E7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

547558:MMAH RS09830
gene id: 547558:MMAH_RS09830
uniprot id: D5E8H1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

547558:MMAH RS02625
gene id: 547558:MMAH_RS02625
uniprot id: D5EA53
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

547558:MMAH RS03045
gene id: 547558:MMAH_RS03045
uniprot id: D5EAC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07005
gene id: 547558:MMAH_RS07005
uniprot id: D5E6W8
names: Similarity
messages: Belongs to the UPF0179 family.

547558:MMAH RS04430
gene id: 547558:MMAH_RS04430
uniprot id: D5EB48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS01600
gene id: 547558:MMAH_RS01600
uniprot id: D5E9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

547558:MMAH RS07720
gene id: 547558:MMAH_RS07720
uniprot id: D5E7B0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS07355
gene id: 547558:MMAH_RS07355
uniprot id: D5E740
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS09430
gene id: 547558:MMAH_RS09430
uniprot id: D5E895
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

547558:MMAH RS03750
gene id: 547558:MMAH_RS03750
uniprot id: D5EAR5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS00440
gene id: 547558:MMAH_RS00440
uniprot id: D5E8W6
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

547558:MMAH RS04170
gene id: 547558:MMAH_RS04170
uniprot id: D5EAZ8
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS09215
gene id: 547558:MMAH_RS09215
uniprot id: D5E852
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

547558:MMAH RS05855
gene id: 547558:MMAH_RS05855
uniprot id: D5EBX5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

547558:MMAH RS03115
gene id: 547558:MMAH_RS03115
uniprot id: D5EAE3
names: Similarity
messages: Belongs to the AAA ATPase family.

547558:MMAH RS08095
gene id: 547558:MMAH_RS08095
uniprot id: D5E7I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS03990
gene id: 547558:MMAH_RS03990
uniprot id: D5EAV9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS03435
gene id: 547558:MMAH_RS03435
uniprot id: D5EAK2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

547558:MMAH RS05165
gene id: 547558:MMAH_RS05165
uniprot id: D5EBJ4
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

547558:MMAH RS08120
gene id: 547558:MMAH_RS08120
uniprot id: D5E7I8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS04790
gene id: 547558:MMAH_RS04790
uniprot id: D5EBC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

547558:MMAH RS06095
gene id: 547558:MMAH_RS06095
uniprot id: D5EC24
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

547558:MMAH RS00800
gene id: 547558:MMAH_RS00800
uniprot id: D5E944
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS06265
gene id: 547558:MMAH_RS06265
uniprot id: D5EC58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

547558:MMAH RS02765
gene id: 547558:MMAH_RS02765
uniprot id: D5EA73
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

547558:MMAH RS05795
gene id: 547558:MMAH_RS05795
uniprot id: D5EBW3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

547558:MMAH RS08470
gene id: 547558:MMAH_RS08470
uniprot id: D5E7Q6
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

547558:MMAH RS06210
gene id: 547558:MMAH_RS06210
uniprot id: D5EC46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS08875
gene id: 547558:MMAH_RS08875
uniprot id: D5E7Y7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS07735
gene id: 547558:MMAH_RS07735
uniprot id: D5E7B3
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06135
gene id: 547558:MMAH_RS06135
uniprot id: D5EC32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

547558:MMAH RS06715
gene id: 547558:MMAH_RS06715
uniprot id: D5E6R0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

547558:MMAH RS09355
gene id: 547558:MMAH_RS09355
uniprot id: D5E880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

547558:MMAH RS05535
gene id: 547558:MMAH_RS05535
uniprot id: D5EBR3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

547558:MMAH RS02450
gene id: 547558:MMAH_RS02450
uniprot id: D5EA20
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

547558:MMAH RS02995
gene id: 547558:MMAH_RS02995
uniprot id: D5EAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

547558:MMAH RS07880
gene id: 547558:MMAH_RS07880
uniprot id: D5E7E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

547558:MMAH RS04350
gene id: 547558:MMAH_RS04350
uniprot id: D5EB33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

547558:MMAH RS07440
gene id: 547558:MMAH_RS07440
uniprot id: D5E755
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

547558:MMAH RS02690
gene id: 547558:MMAH_RS02690
uniprot id: D5EA65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS04820
gene id: 547558:MMAH_RS04820
uniprot id: D5EBC6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

547558:MMAH RS04075
gene id: 547558:MMAH_RS04075
uniprot id: D5EAX8
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

547558:MMAH RS05295
gene id: 547558:MMAH_RS05295
uniprot id: D5EBL6
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS05180
gene id: 547558:MMAH_RS05180
uniprot id: D5EBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

547558:MMAH RS01130
gene id: 547558:MMAH_RS01130
uniprot id: D5E9B1
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

547558:MMAH RS06010
gene id: 547558:MMAH_RS06010
uniprot id: D5EC07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

547558:MMAH RS01650
gene id: 547558:MMAH_RS01650
uniprot id: D5E9L6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

547558:MMAH RS06215
gene id: 547558:MMAH_RS06215
uniprot id: D5EC47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

547558:MMAH RS00860
gene id: 547558:MMAH_RS00860
uniprot id: D5E956
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

547558:MMAH RS07585
gene id: 547558:MMAH_RS07585
uniprot id: D5E784
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS10125
gene id: 547558:MMAH_RS10125
uniprot id: D5E8M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS02645
gene id: 547558:MMAH_RS02645
uniprot id: D5EA56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS10005
gene id: 547558:MMAH_RS10005
uniprot id: D5E8K4
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03995
gene id: 547558:MMAH_RS03995
uniprot id: D5EAW0
names: Similarity
messages: Belongs to the UPF0284 family.

547558:MMAH RS02370
gene id: 547558:MMAH_RS02370
uniprot id: D5EA06
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

547558:MMAH RS05650
gene id: 547558:MMAH_RS05650
uniprot id: D5EBT7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

547558:MMAH RS06585
gene id: 547558:MMAH_RS06585
uniprot id: D5E6N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS02595
gene id: 547558:MMAH_RS02595
uniprot id: D5EA47
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

547558:MMAH RS07230
gene id: 547558:MMAH_RS07230
uniprot id: D5E716
names: Similarity
messages: Belongs to the Ahb/Nir family.

547558:MMAH RS07895
gene id: 547558:MMAH_RS07895
uniprot id: D5E7E3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS07210
gene id: 547558:MMAH_RS07210
uniprot id: D5E712
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

547558:MMAH RS00020
gene id: 547558:MMAH_RS00020
uniprot id: D5E8N3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

547558:MMAH RS04240
gene id: 547558:MMAH_RS04240
uniprot id: D5EB12
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

547558:MMAH RS01115
gene id: 547558:MMAH_RS01115
uniprot id: D5E9A8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

547558:MMAH RS10180
gene id: 547558:MMAH_RS10180
uniprot id: D5E8Z3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

547558:MMAH RS09920
gene id: 547558:MMAH_RS09920
uniprot id: D5E8I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

547558:MMAH RS00270
gene id: 547558:MMAH_RS00270
uniprot id: D5E8T4
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS01300
gene id: 547558:MMAH_RS01300
uniprot id: D5E9E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

547558:MMAH RS02790
gene id: 547558:MMAH_RS02790
uniprot id: D5EA78
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

547558:MMAH RS08050
gene id: 547558:MMAH_RS08050
uniprot id: D5E7H4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

547558:MMAH RS00405
gene id: 547558:MMAH_RS00405
uniprot id: D5E8V9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS08425
gene id: 547558:MMAH_RS08425
uniprot id: D5E7P7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

547558:MMAH RS04455
gene id: 547558:MMAH_RS04455
uniprot id: D5EB54
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS04190
gene id: 547558:MMAH_RS04190
uniprot id: D5EB02
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

547558:MMAH RS09710
gene id: 547558:MMAH_RS09710
uniprot id: D5E8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

547558:MMAH RS04015
gene id: 547558:MMAH_RS04015
uniprot id: D5EAW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

547558:MMAH RS10160
gene id: 547558:MMAH_RS10160
uniprot id: D5E8Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

547558:MMAH RS01910
gene id: 547558:MMAH_RS01910
uniprot id: D5E9R8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

547558:MMAH RS02905
gene id: 547558:MMAH_RS02905
uniprot id: D5EAA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

547558:MMAH RS01025
gene id: 547558:MMAH_RS01025
uniprot id: D5E990
names: Similarity
messages: Belongs to the UPF0235 family.

547558:MMAH RS05825
gene id: 547558:MMAH_RS05825
uniprot id: D5EBW9
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS03280
gene id: 547558:MMAH_RS03280
uniprot id: D5EAH6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

547558:MMAH RS03830
gene id: 547558:MMAH_RS03830
uniprot id: D5EAS8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

547558:MMAH RS02490
gene id: 547558:MMAH_RS02490
uniprot id: D5EA26
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS01175
gene id: 547558:MMAH_RS01175
uniprot id: D5E9C0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS09135
gene id: 547558:MMAH_RS09135
uniprot id: D5E838
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

547558:MMAH RS08650
gene id: 547558:MMAH_RS08650
uniprot id: D5E7U3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

547558:MMAH RS08275
gene id: 547558:MMAH_RS08275
uniprot id: D5E7L8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

547558:MMAH RS08085
gene id: 547558:MMAH_RS08085
uniprot id: D5E7I1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

547558:MMAH RS00015
gene id: 547558:MMAH_RS00015
uniprot id: D5E8N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

547558:MMAH RS07690
gene id: 547558:MMAH_RS07690
uniprot id: D5E7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS08910
gene id: 547558:MMAH_RS08910
uniprot id: D5E7Z4
names: Similarity
messages: Belongs to the HdrC family.

547558:MMAH RS02960
gene id: 547558:MMAH_RS02960
uniprot id: D5EAB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

547558:MMAH RS05395
gene id: 547558:MMAH_RS05395
uniprot id: D5EBN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

547558:MMAH RS06840
gene id: 547558:MMAH_RS06840
uniprot id: D5E6T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

547558:MMAH RS06015
gene id: 547558:MMAH_RS06015
uniprot id: D5EC08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

547558:MMAH RS06945
gene id: 547558:MMAH_RS06945
uniprot id: D5E6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

547558:MMAH RS02360
gene id: 547558:MMAH_RS02360
uniprot id: D5EA04
names: Similarity
messages: Belongs to the malic enzymes family.

547558:MMAH RS00610
gene id: 547558:MMAH_RS00610
uniprot id: D5E908
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

547558:MMAH RS06750
gene id: 547558:MMAH_RS06750
uniprot id: D5E6R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

547558:MMAH RS06285
gene id: 547558:MMAH_RS06285
uniprot id: D5EC62
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

547558:MMAH RS08015
gene id: 547558:MMAH_RS08015
uniprot id: D5E7G7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

547558:MMAH RS07295
gene id: 547558:MMAH_RS07295
uniprot id: D5E729
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

547558:MMAH RS01000
gene id: 547558:MMAH_RS01000
uniprot id: D5E984
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

547558:MMAH RS08690
gene id: 547558:MMAH_RS08690
uniprot id: D5E7V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS01560
gene id: 547558:MMAH_RS01560
uniprot id: D5E9J8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

547558:MMAH RS03540
gene id: 547558:MMAH_RS03540
uniprot id: D5EAM5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

547558:MMAH RS03020
gene id: 547558:MMAH_RS03020
uniprot id: D5EAC5
names: Similarity
messages: Belongs to the UPF0047 family.

547558:MMAH RS08480
gene id: 547558:MMAH_RS08480
uniprot id: D5E7Q8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

547558:MMAH RS08020
gene id: 547558:MMAH_RS08020
uniprot id: D5E7G8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

547558:MMAH RS05020
gene id: 547558:MMAH_RS05020
uniprot id: D5EBG5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

547558:MMAH RS06680
gene id: 547558:MMAH_RS06680
uniprot id: D5E6Q3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

547558:MMAH RS03615
gene id: 547558:MMAH_RS03615
uniprot id: D5EAN9
names: Similarity
messages: Belongs to the UPF0285 family.

547558:MMAH RS01240
gene id: 547558:MMAH_RS01240
uniprot id: D5E9D2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

547558:MMAH RS08165
gene id: 547558:MMAH_RS08165
uniprot id: D5E7J5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

547558:MMAH RS08325
gene id: 547558:MMAH_RS08325
uniprot id: D5E7M8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

547558:MMAH RS00845
gene id: 547558:MMAH_RS00845
uniprot id: D5E953
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

547558:MMAH RS03635
gene id: 547558:MMAH_RS03635
uniprot id: D5EAP3
names: Similarity
messages: Belongs to the UPF0758 family.

547558:MMAH RS08855
gene id: 547558:MMAH_RS08855
uniprot id: D5E7Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS00820
gene id: 547558:MMAH_RS00820
uniprot id: D5E948
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

547558:MMAH RS07510
gene id: 547558:MMAH_RS07510
uniprot id: D5E769
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

547558:MMAH RS05195
gene id: 547558:MMAH_RS05195
uniprot id: D5EBK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

547558:MMAH RS03845
gene id: 547558:MMAH_RS03845
uniprot id: D5EAT2
names: Similarity
messages: Belongs to the IMPACT family.

547558:MMAH RS04205
gene id: 547558:MMAH_RS04205
uniprot id: D5EB05
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

547558:MMAH RS01905
gene id: 547558:MMAH_RS01905
uniprot id: D5E9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

547558:MMAH RS03215
gene id: 547558:MMAH_RS03215
uniprot id: D5EAG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

547558:MMAH RS06060
gene id: 547558:MMAH_RS06060
uniprot id: D5EC17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

547558:MMAH RS02025
gene id: 547558:MMAH_RS02025
uniprot id: D5E9U1
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

547558:MMAH RS01940
gene id: 547558:MMAH_RS01940
uniprot id: D5E9S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

547558:MMAH RS01935
gene id: 547558:MMAH_RS01935
uniprot id: D5E9S3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

547558:MMAH RS00105
gene id: 547558:MMAH_RS00105
uniprot id: D5E8Q0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS02990
gene id: 547558:MMAH_RS02990
uniprot id: D5EAB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS07855
gene id: 547558:MMAH_RS07855
uniprot id: D5E7D5
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06705
gene id: 547558:MMAH_RS06705
uniprot id: D5E6Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

547558:MMAH RS04440
gene id: 547558:MMAH_RS04440
uniprot id: D5EB50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

547558:MMAH RS09470
gene id: 547558:MMAH_RS09470
uniprot id: D5E8A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

547558:MMAH RS05465
gene id: 547558:MMAH_RS05465
uniprot id: D5EBP7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

547558:MMAH RS05640
gene id: 547558:MMAH_RS05640
uniprot id: D5EBT5
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06380
gene id: 547558:MMAH_RS06380
uniprot id: D5E6J6
names: Similarity
messages: Belongs to the class-I fumarase family.

547558:MMAH RS02910
gene id: 547558:MMAH_RS02910
uniprot id: D5EAA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

547558:MMAH RS08630
gene id: 547558:MMAH_RS08630
uniprot id: D5E7T9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

547558:MMAH RS01065
gene id: 547558:MMAH_RS01065
uniprot id: D5E998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

547558:MMAH RS02435
gene id: 547558:MMAH_RS02435
uniprot id: D5EA17
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

547558:MMAH RS02515
gene id: 547558:MMAH_RS02515
uniprot id: D5EA31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

547558:MMAH RS05285
gene id: 547558:MMAH_RS05285
uniprot id: D5EBL4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

547558:MMAH RS00650
gene id: 547558:MMAH_RS00650
uniprot id: D5E915
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS05605
gene id: 547558:MMAH_RS05605
uniprot id: D5EBS8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

547558:MMAH RS05930
gene id: 547558:MMAH_RS05930
uniprot id: D5EBZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS00170
gene id: 547558:MMAH_RS00170
uniprot id: D5E8R3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

547558:MMAH RS08055
gene id: 547558:MMAH_RS08055
uniprot id: D5E7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

547558:MMAH RS08860
gene id: 547558:MMAH_RS08860
uniprot id: D5E7Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS08375
gene id: 547558:MMAH_RS08375
uniprot id: D5E7N7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

547558:MMAH RS05515
gene id: 547558:MMAH_RS05515
uniprot id: D5EBQ7
names: Similarity
messages: Belongs to the DEAD box helicase family.

547558:MMAH RS02635
gene id: 547558:MMAH_RS02635
uniprot id: D5EA54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS03165
gene id: 547558:MMAH_RS03165
uniprot id: D5EAF3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

547558:MMAH RS01605
gene id: 547558:MMAH_RS01605
uniprot id: D5E9K7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS06930
gene id: 547558:MMAH_RS06930
uniprot id: D5E6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

547558:MMAH RS07240
gene id: 547558:MMAH_RS07240
uniprot id: D5E718
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

547558:MMAH RS07095
gene id: 547558:MMAH_RS07095
uniprot id: D5E6Y7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

547558:MMAH RS00260
gene id: 547558:MMAH_RS00260
uniprot id: D5E8T2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

547558:MMAH RS01630
gene id: 547558:MMAH_RS01630
uniprot id: D5E9L2
names: Similarity
messages: Belongs to the UPF0251 family.

547558:MMAH RS01980
gene id: 547558:MMAH_RS01980
uniprot id: D5E9T2
names: Similarity
messages: Belongs to the MtxX family.

547558:MMAH RS08605
gene id: 547558:MMAH_RS08605
uniprot id: D5E7T4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

547558:MMAH RS04060
gene id: 547558:MMAH_RS04060
uniprot id: D5EAX5
names: Similarity
messages: Belongs to the LarC family.

547558:MMAH RS01750
gene id: 547558:MMAH_RS01750
uniprot id: D5E9N6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

547558:MMAH RS05120
gene id: 547558:MMAH_RS05120
uniprot id: D5EBI5
names: Similarity
messages: Belongs to the peptidase U62 family.

547558:MMAH RS09200
gene id: 547558:MMAH_RS09200
uniprot id: D5E849
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

547558:MMAH RS07300
gene id: 547558:MMAH_RS07300
uniprot id: D5E730
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

547558:MMAH RS07955
gene id: 547558:MMAH_RS07955
uniprot id: D5E7F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

547558:MMAH RS04715
gene id: 547558:MMAH_RS04715
uniprot id: D5EBA5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

547558:MMAH RS03965
gene id: 547558:MMAH_RS03965
uniprot id: D5EAV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

547558:MMAH RS07935
gene id: 547558:MMAH_RS07935
uniprot id: D5E7F1
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS09395
gene id: 547558:MMAH_RS09395
uniprot id: D5E888
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS01715
gene id: 547558:MMAH_RS01715
uniprot id: D5E9M9
names: Similarity
messages: Belongs to the UPF0201 family.

547558:MMAH RS09500
gene id: 547558:MMAH_RS09500
uniprot id: D5E8B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

547558:MMAH RS04720
gene id: 547558:MMAH_RS04720
uniprot id: D5EBA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

547558:MMAH RS04320
gene id: 547558:MMAH_RS04320
uniprot id: D5EB27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

547558:MMAH RS01125
gene id: 547558:MMAH_RS01125
uniprot id: D5E9B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

547558:MMAH RS07665
gene id: 547558:MMAH_RS07665
uniprot id: D5E7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

547558:MMAH RS10045
gene id: 547558:MMAH_RS10045
uniprot id: D5E8L0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

547558:MMAH RS00555
gene id: 547558:MMAH_RS00555
uniprot id: D5E8Z7
names: Similarity
messages: Belongs to the peptidase C1 family.

547558:MMAH RS03500
gene id: 547558:MMAH_RS03500
uniprot id: D5EAL6
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

547558:MMAH RS08905
gene id: 547558:MMAH_RS08905
uniprot id: D5E7Z3
names: Similarity
messages: Belongs to the HdrB family.

547558:MMAH RS02010
gene id: 547558:MMAH_RS02010
uniprot id: D5E9T8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

547558:MMAH RS06000
gene id: 547558:MMAH_RS06000
uniprot id: D5EC05
names: Similarity
messages: Belongs to the glutaredoxin family.

547558:MMAH RS04425
gene id: 547558:MMAH_RS04425
uniprot id: D5EB47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

547558:MMAH RS04050
gene id: 547558:MMAH_RS04050
uniprot id: D5EAX2
names: Function
messages: Probably involved in the biogenesis of the ribosome.

547558:MMAH RS08715
gene id: 547558:MMAH_RS08715
uniprot id: D5E7V5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

547558:MMAH RS03885
gene id: 547558:MMAH_RS03885
uniprot id: D5EAU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

547558:MMAH RS07035
gene id: 547558:MMAH_RS07035
uniprot id: D5E6X4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

547558:MMAH RS04800
gene id: 547558:MMAH_RS04800
uniprot id: D5EBC2
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

547558:MMAH RS01755
gene id: 547558:MMAH_RS01755
uniprot id: D5E9N7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

547558:MMAH RS03260
gene id: 547558:MMAH_RS03260
uniprot id: D5EAH2
names: Similarity
messages: Belongs to the UPF0212 family.

547558:MMAH RS10310
gene id: 547558:MMAH_RS10310
uniprot id: D5EAX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

547558:MMAH RS08925
gene id: 547558:MMAH_RS08925
uniprot id: D5E7Z7
names: Similarity
messages: Belongs to the glutamate synthase family.

547558:MMAH RS06075
gene id: 547558:MMAH_RS06075
uniprot id: D5EC20
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

547558:MMAH RS09295
gene id: 547558:MMAH_RS09295
uniprot id: D5E868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

547558:MMAH RS06785
gene id: 547558:MMAH_RS06785
uniprot id: D5E6S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

547558:MMAH RS02800
gene id: 547558:MMAH_RS02800
uniprot id: D5EA80
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

547558:MMAH RS02365
gene id: 547558:MMAH_RS02365
uniprot id: D5EA05
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

547558:MMAH RS05665
gene id: 547558:MMAH_RS05665
uniprot id: D5EBU0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS02000
gene id: 547558:MMAH_RS02000
uniprot id: D5E9T6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS06950
gene id: 547558:MMAH_RS06950
uniprot id: D5E6V7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

547558:MMAH RS08895
gene id: 547558:MMAH_RS08895
uniprot id: D5E7Z1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

547558:MMAH RS02820
gene id: 547558:MMAH_RS02820
uniprot id: D5EA84
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

547558:MMAH RS06085
gene id: 547558:MMAH_RS06085
uniprot id: D5EC22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

547558:MMAH RS03625
gene id: 547558:MMAH_RS03625
uniprot id: D5EAP1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

547558:MMAH RS07180
gene id: 547558:MMAH_RS07180
uniprot id: D5E706
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

547558:MMAH RS06520
gene id: 547558:MMAH_RS06520
uniprot id: D5E6M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

547558:MMAH RS06710
gene id: 547558:MMAH_RS06710
uniprot id: D5E6Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

547558:MMAH RS04130
gene id: 547558:MMAH_RS04130
uniprot id: D5EAZ0
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS06185
gene id: 547558:MMAH_RS06185
uniprot id: D5EC42
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

547558:MMAH RS00900
gene id: 547558:MMAH_RS00900
uniprot id: D5E965
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

547558:MMAH RS09895
gene id: 547558:MMAH_RS09895
uniprot id: D5E8I4
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

547558:MMAH RS08475
gene id: 547558:MMAH_RS08475
uniprot id: D5E7Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

547558:MMAH RS01955
gene id: 547558:MMAH_RS01955
uniprot id: D5E9S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

547558:MMAH RS06790
gene id: 547558:MMAH_RS06790
uniprot id: D5E6S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

547558:MMAH RS08825
gene id: 547558:MMAH_RS08825
uniprot id: D5E7X7
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS07640
gene id: 547558:MMAH_RS07640
uniprot id: D5E795
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

547558:MMAH RS06615
gene id: 547558:MMAH_RS06615
uniprot id: D5E6P1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

547558:MMAH RS08635
gene id: 547558:MMAH_RS08635
uniprot id: D5E7U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

547558:MMAH RS08040
gene id: 547558:MMAH_RS08040
uniprot id: D5E7H2
names: Function
messages: Part of a potassium transport system.

547558:MMAH RS02225
gene id: 547558:MMAH_RS02225
uniprot id: D5E9X8
names: Similarity
messages: Belongs to the AAA ATPase family.

547558:MMAH RS01290
gene id: 547558:MMAH_RS01290
uniprot id: D5E9E3
names: Similarity
messages: Belongs to the SUI1 family.

547558:MMAH RS02680
gene id: 547558:MMAH_RS02680
uniprot id: D5EA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

547558:MMAH RS03915
gene id: 547558:MMAH_RS03915
uniprot id: D5EAU6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

547558:MMAH RS00795
gene id: 547558:MMAH_RS00795
uniprot id: D5E943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

547558:MMAH RS01930
gene id: 547558:MMAH_RS01930
uniprot id: D5E9S2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

547558:MMAH RS08210
gene id: 547558:MMAH_RS08210
uniprot id: D5E7K4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

547558:MMAH RS07920
gene id: 547558:MMAH_RS07920
uniprot id: D5E7E8
names: Subcellular Location Annotation
messages: Membrane

547558:MMAH RS08140
gene id: 547558:MMAH_RS08140
uniprot id: D5E7J2
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

547558:MMAH RS08880
gene id: 547558:MMAH_RS08880
uniprot id: D5E7Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

547558:MMAH RS07260
gene id: 547558:MMAH_RS07260
uniprot id: D5E722
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

547558:MMAH RS05600
gene id: 547558:MMAH_RS05600
uniprot id: D5EBS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

547558:MMAH RS09915
gene id: 547558:MMAH_RS09915
uniprot id: D5E8I8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

547558:MMAH RS09835
gene id: 547558:MMAH_RS09835
uniprot id: D5E8H2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

547558:MMAH RS06355
gene id: 547558:MMAH_RS06355
uniprot id: D5E6J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

547558:MMAH RS08500
gene id: 547558:MMAH_RS08500
uniprot id: D5E7R2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

547558:MMAH RS07375
gene id: 547558:MMAH_RS07375
uniprot id: D5E742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

547558:MMAH RS03695
gene id: 547558:MMAH_RS03695
uniprot id: D5EAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

547558:MMAH RS05190
gene id: 547558:MMAH_RS05190
uniprot id: D5EBJ9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

547558:MMAH RS06205
gene id: 547558:MMAH_RS06205
uniprot id: D5EC45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.