546269:HMPREF0389 RS07265
gene id: 546269:HMPREF0389_RS07265
uniprot id: D6GQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS06750
gene id: 546269:HMPREF0389_RS06750
uniprot id: D6GQB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS06080
gene id: 546269:HMPREF0389_RS06080
uniprot id: E8RKD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

546269:HMPREF0389 RS06430
gene id: 546269:HMPREF0389_RS06430
uniprot id: D6GQ50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

546269:HMPREF0389 RS03275
gene id: 546269:HMPREF0389_RS03275
uniprot id: D6GU59
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

546269:HMPREF0389 RS03980
gene id: 546269:HMPREF0389_RS03980
uniprot id: D6GTU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS07360
gene id: 546269:HMPREF0389_RS07360
uniprot id: D6GQN9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

546269:HMPREF0389 RS06380
gene id: 546269:HMPREF0389_RS06380
uniprot id: D6GQ41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

546269:HMPREF0389 RS01300
gene id: 546269:HMPREF0389_RS01300
uniprot id: D6GS16
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

546269:HMPREF0389 RS01745
gene id: 546269:HMPREF0389_RS01745
uniprot id: D6GRS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS00690
gene id: 546269:HMPREF0389_RS00690
uniprot id: D6GSD6
names: Similarity
messages: Belongs to the GARS family.

546269:HMPREF0389 RS02870
gene id: 546269:HMPREF0389_RS02870
uniprot id: D6GR58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

546269:HMPREF0389 RS02225
gene id: 546269:HMPREF0389_RS02225
uniprot id: D6GRI4
names: Similarity
messages: Belongs to the type IA topoisomerase family.

546269:HMPREF0389 RS05180
gene id: 546269:HMPREF0389_RS05180
uniprot id: D6GSL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS02125
gene id: 546269:HMPREF0389_RS02125
uniprot id: D6GRK4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: Belongs to the CRISPR-associated protein Cas9 family. Subtype II-A subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Binds crRNA and tracrRNA.

546269:HMPREF0389 RS05515
gene id: 546269:HMPREF0389_RS05515
uniprot id: D6GPL5
names: Similarity
messages: Belongs to the peptidase C40 family.

546269:HMPREF0389 RS03835
gene id: 546269:HMPREF0389_RS03835
uniprot id: D6GTW8
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

546269:HMPREF0389 RS00210
gene id: 546269:HMPREF0389_RS00210
uniprot id: D6GSR8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

546269:HMPREF0389 RS01210
gene id: 546269:HMPREF0389_RS01210
uniprot id: D6GS34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS02530
gene id: 546269:HMPREF0389_RS02530
uniprot id: D6GRC5
names: Similarity
messages: Belongs to the DprA/Smf family.

546269:HMPREF0389 RS00525
gene id: 546269:HMPREF0389_RS00525
uniprot id: D6GSG9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

546269:HMPREF0389 RS02325
gene id: 546269:HMPREF0389_RS02325
uniprot id: D6GRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS02800
gene id: 546269:HMPREF0389_RS02800
uniprot id: D6GR72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS02925
gene id: 546269:HMPREF0389_RS02925
uniprot id: D6GR47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

546269:HMPREF0389 RS08615
gene id: 546269:HMPREF0389_RS08615
uniprot id: D6GSW6
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS02630
gene id: 546269:HMPREF0389_RS02630
uniprot id: D6GRA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

546269:HMPREF0389 RS02000
gene id: 546269:HMPREF0389_RS02000
uniprot id: D6GRN0
names: Similarity
messages: Belongs to the MT-A70-like family.

546269:HMPREF0389 RS02555
gene id: 546269:HMPREF0389_RS02555
uniprot id: D6GRC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS01540
gene id: 546269:HMPREF0389_RS01540
uniprot id: D6GRW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

546269:HMPREF0389 RS06285
gene id: 546269:HMPREF0389_RS06285
uniprot id: D6GQ21
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

546269:HMPREF0389 RS06435
gene id: 546269:HMPREF0389_RS06435
uniprot id: D6GQ51
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

546269:HMPREF0389 RS06215
gene id: 546269:HMPREF0389_RS06215
uniprot id: D6GQ05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

546269:HMPREF0389 RS06685
gene id: 546269:HMPREF0389_RS06685
uniprot id: D6GQA1
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06395
gene id: 546269:HMPREF0389_RS06395
uniprot id: D6GQ44
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

546269:HMPREF0389 RS00855
gene id: 546269:HMPREF0389_RS00855
uniprot id: D6GSA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

546269:HMPREF0389 RS04260
gene id: 546269:HMPREF0389_RS04260
uniprot id: D6GTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

546269:HMPREF0389 RS05040
gene id: 546269:HMPREF0389_RS05040
uniprot id: D6GU70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

546269:HMPREF0389 RS04270
gene id: 546269:HMPREF0389_RS04270
uniprot id: D6GTP3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

546269:HMPREF0389 RS00910
gene id: 546269:HMPREF0389_RS00910
uniprot id: D6GS92
names: Similarity
messages: Belongs to the peptidase M18 family.

546269:HMPREF0389 RS02940
gene id: 546269:HMPREF0389_RS02940
uniprot id: D6GR44
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS03355
gene id: 546269:HMPREF0389_RS03355
uniprot id: D6GU43
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

546269:HMPREF0389 RS01175
gene id: 546269:HMPREF0389_RS01175
uniprot id: D6GS41
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

546269:HMPREF0389 RS02815
gene id: 546269:HMPREF0389_RS02815
uniprot id: D6GR69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS00765
gene id: 546269:HMPREF0389_RS00765
uniprot id: D6GSC2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

546269:HMPREF0389 RS04245
gene id: 546269:HMPREF0389_RS04245
uniprot id: D6GTP8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

546269:HMPREF0389 RS06355
gene id: 546269:HMPREF0389_RS06355
uniprot id: E8RK56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

546269:HMPREF0389 RS05200
gene id: 546269:HMPREF0389_RS05200
uniprot id: D6GSL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

546269:HMPREF0389 RS06400
gene id: 546269:HMPREF0389_RS06400
uniprot id: D6GQ45
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

546269:HMPREF0389 RS06480
gene id: 546269:HMPREF0389_RS06480
uniprot id: D6GQ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

546269:HMPREF0389 RS04220
gene id: 546269:HMPREF0389_RS04220
uniprot id: D6GTQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

546269:HMPREF0389 RS08605
gene id: 546269:HMPREF0389_RS08605
uniprot id: D6GSW8
names: Similarity
messages: Belongs to the ParB family.

546269:HMPREF0389 RS07345
gene id: 546269:HMPREF0389_RS07345
uniprot id: D6GQN6
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS02015
gene id: 546269:HMPREF0389_RS02015
uniprot id: D6GRM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

546269:HMPREF0389 RS02185
gene id: 546269:HMPREF0389_RS02185
uniprot id: D6GRJ2
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

546269:HMPREF0389 RS04250
gene id: 546269:HMPREF0389_RS04250
uniprot id: D6GTP7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

546269:HMPREF0389 RS07830
gene id: 546269:HMPREF0389_RS07830
uniprot id: D6GQX9
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

546269:HMPREF0389 RS04490
gene id: 546269:HMPREF0389_RS04490
uniprot id: D6GTK0
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06045
gene id: 546269:HMPREF0389_RS06045
uniprot id: D6GPX4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

546269:HMPREF0389 RS06590
gene id: 546269:HMPREF0389_RS06590
uniprot id: E8RK60
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

546269:HMPREF0389 RS02625
gene id: 546269:HMPREF0389_RS02625
uniprot id: D6GRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

546269:HMPREF0389 RS03830
gene id: 546269:HMPREF0389_RS03830
uniprot id: D6GTX0
names: Similarity
messages: Belongs to the UPF0167 family.

546269:HMPREF0389 RS00635
gene id: 546269:HMPREF0389_RS00635
uniprot id: D6GSE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

546269:HMPREF0389 RS01705
gene id: 546269:HMPREF0389_RS01705
uniprot id: D6GRT5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

546269:HMPREF0389 RS03105
gene id: 546269:HMPREF0389_RS03105
uniprot id: D6GR10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

546269:HMPREF0389 RS00755
gene id: 546269:HMPREF0389_RS00755
uniprot id: D6GSC4
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

546269:HMPREF0389 RS06500
gene id: 546269:HMPREF0389_RS06500
uniprot id: D6GQ64
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

546269:HMPREF0389 RS00770
gene id: 546269:HMPREF0389_RS00770
uniprot id: D6GSC1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

546269:HMPREF0389 RS00260
gene id: 546269:HMPREF0389_RS00260
uniprot id: D6GSQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

546269:HMPREF0389 RS06055
gene id: 546269:HMPREF0389_RS06055
uniprot id: D6GPX6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

546269:HMPREF0389 RS08420
gene id: 546269:HMPREF0389_RS08420
uniprot id: D6GT06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

546269:HMPREF0389 RS02150
gene id: 546269:HMPREF0389_RS02150
uniprot id: D6GRJ9
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS07930
gene id: 546269:HMPREF0389_RS07930
uniprot id: E8RK79
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01905
gene id: 546269:HMPREF0389_RS01905
uniprot id: D6GRP9
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06465
gene id: 546269:HMPREF0389_RS06465
uniprot id: D6GQ57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

546269:HMPREF0389 RS05155
gene id: 546269:HMPREF0389_RS05155
uniprot id: D6GSK9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

546269:HMPREF0389 RS06410
gene id: 546269:HMPREF0389_RS06410
uniprot id: D6GQ47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

546269:HMPREF0389 RS06925
gene id: 546269:HMPREF0389_RS06925
uniprot id: D6GQE8
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS01365
gene id: 546269:HMPREF0389_RS01365
uniprot id: D6GS03
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

546269:HMPREF0389 RS06570
gene id: 546269:HMPREF0389_RS06570
uniprot id: D6GQ79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

546269:HMPREF0389 RS02025
gene id: 546269:HMPREF0389_RS02025
uniprot id: D6GRM5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

546269:HMPREF0389 RS04430
gene id: 546269:HMPREF0389_RS04430
uniprot id: D6GTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

546269:HMPREF0389 RS01510
gene id: 546269:HMPREF0389_RS01510
uniprot id: D6GRX5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

546269:HMPREF0389 RS05050
gene id: 546269:HMPREF0389_RS05050
uniprot id: D6GU68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

546269:HMPREF0389 RS00035
gene id: 546269:HMPREF0389_RS00035
uniprot id: D6GSV3
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS00725
gene id: 546269:HMPREF0389_RS00725
uniprot id: E8RK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

546269:HMPREF0389 RS01435
gene id: 546269:HMPREF0389_RS01435
uniprot id: D6GRZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

546269:HMPREF0389 RS01605
gene id: 546269:HMPREF0389_RS01605
uniprot id: D6GRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

546269:HMPREF0389 RS01635
gene id: 546269:HMPREF0389_RS01635
uniprot id: D6GRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

546269:HMPREF0389 RS05140
gene id: 546269:HMPREF0389_RS05140
uniprot id: D6GSK6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

546269:HMPREF0389 RS06715
gene id: 546269:HMPREF0389_RS06715
uniprot id: D6GQA7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

546269:HMPREF0389 RS03915
gene id: 546269:HMPREF0389_RS03915
uniprot id: D6GTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

546269:HMPREF0389 RS00495
gene id: 546269:HMPREF0389_RS00495
uniprot id: D6GSH5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

546269:HMPREF0389 RS08230
gene id: 546269:HMPREF0389_RS08230
uniprot id: D6GT41
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS02115
gene id: 546269:HMPREF0389_RS02115
uniprot id: D6GRK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

546269:HMPREF0389 RS05890
gene id: 546269:HMPREF0389_RS05890
uniprot id: D6GPT9
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

546269:HMPREF0389 RS08120
gene id: 546269:HMPREF0389_RS08120
uniprot id: D6GT63
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

546269:HMPREF0389 RS06490
gene id: 546269:HMPREF0389_RS06490
uniprot id: D6GQ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

546269:HMPREF0389 RS06415
gene id: 546269:HMPREF0389_RS06415
uniprot id: E8RK57
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

546269:HMPREF0389 RS07900
gene id: 546269:HMPREF0389_RS07900
uniprot id: D6GQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

546269:HMPREF0389 RS03260
gene id: 546269:HMPREF0389_RS03260
uniprot id: D6GU62
names: Similarity
messages: Belongs to the CinA family.

546269:HMPREF0389 RS01665
gene id: 546269:HMPREF0389_RS01665
uniprot id: D6GRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

546269:HMPREF0389 RS07285
gene id: 546269:HMPREF0389_RS07285
uniprot id: D6GQM4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS07145
gene id: 546269:HMPREF0389_RS07145
uniprot id: D6GQJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

546269:HMPREF0389 RS05350
gene id: 546269:HMPREF0389_RS05350
uniprot id: D6GPI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

546269:HMPREF0389 RS04110
gene id: 546269:HMPREF0389_RS04110
uniprot id: D6GTR8
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

546269:HMPREF0389 RS05135
gene id: 546269:HMPREF0389_RS05135
uniprot id: D6GSK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

546269:HMPREF0389 RS01660
gene id: 546269:HMPREF0389_RS01660
uniprot id: D6GRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

546269:HMPREF0389 RS06830
gene id: 546269:HMPREF0389_RS06830
uniprot id: D6GQD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

546269:HMPREF0389 RS07325
gene id: 546269:HMPREF0389_RS07325
uniprot id: D6GQN2
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

546269:HMPREF0389 RS01580
gene id: 546269:HMPREF0389_RS01580
uniprot id: D6GRW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

546269:HMPREF0389 RS02750
gene id: 546269:HMPREF0389_RS02750
uniprot id: D6GR83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

546269:HMPREF0389 RS04630
gene id: 546269:HMPREF0389_RS04630
uniprot id: D6GTH2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

546269:HMPREF0389 RS07330
gene id: 546269:HMPREF0389_RS07330
uniprot id: D6GQN3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

546269:HMPREF0389 RS08430
gene id: 546269:HMPREF0389_RS08430
uniprot id: D6GT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS03350
gene id: 546269:HMPREF0389_RS03350
uniprot id: D6GU44
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

546269:HMPREF0389 RS00880
gene id: 546269:HMPREF0389_RS00880
uniprot id: D6GS98
names: Similarity
messages: Belongs to the ArsC family.

546269:HMPREF0389 RS05505
gene id: 546269:HMPREF0389_RS05505
uniprot id: D6GPL3
names: Function
messages: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.

546269:HMPREF0389 RS06785
gene id: 546269:HMPREF0389_RS06785
uniprot id: D6GQC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS03785
gene id: 546269:HMPREF0389_RS03785
uniprot id: D6GTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

546269:HMPREF0389 RS00150
gene id: 546269:HMPREF0389_RS00150
uniprot id: D6GST0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

546269:HMPREF0389 RS07260
gene id: 546269:HMPREF0389_RS07260
uniprot id: D6GQL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS08440
gene id: 546269:HMPREF0389_RS08440
uniprot id: D6GT01
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

546269:HMPREF0389 RS06585
gene id: 546269:HMPREF0389_RS06585
uniprot id: E8RK59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

546269:HMPREF0389 RS06260
gene id: 546269:HMPREF0389_RS06260
uniprot id: D6GQ15
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

546269:HMPREF0389 RS01380
gene id: 546269:HMPREF0389_RS01380
uniprot id: D6GS00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

546269:HMPREF0389 RS05195
gene id: 546269:HMPREF0389_RS05195
uniprot id: D6GSL7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

546269:HMPREF0389 RS02720
gene id: 546269:HMPREF0389_RS02720
uniprot id: D6GR87
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

546269:HMPREF0389 RS00815
gene id: 546269:HMPREF0389_RS00815
uniprot id: D6GSB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS00385
gene id: 546269:HMPREF0389_RS00385
uniprot id: D6GSJ7
names: Similarity
messages: Belongs to the transpeptidase family.

546269:HMPREF0389 RS02980
gene id: 546269:HMPREF0389_RS02980
uniprot id: D6GR36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

546269:HMPREF0389 RS00670
gene id: 546269:HMPREF0389_RS00670
uniprot id: D6GSE0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS04515
gene id: 546269:HMPREF0389_RS04515
uniprot id: D6GTJ5
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

546269:HMPREF0389 RS02510
gene id: 546269:HMPREF0389_RS02510
uniprot id: D6GRC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

546269:HMPREF0389 RS08085
gene id: 546269:HMPREF0389_RS08085
uniprot id: D6GT70
names: Similarity
messages: Belongs to the peptidase U62 family.

546269:HMPREF0389 RS04810
gene id: 546269:HMPREF0389_RS04810
uniprot id: D6GTD4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

546269:HMPREF0389 RS07470
gene id: 546269:HMPREF0389_RS07470
uniprot id: D6GQR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

546269:HMPREF0389 RS01650
gene id: 546269:HMPREF0389_RS01650
uniprot id: D6GRU7
names: Similarity
messages: Belongs to the transpeptidase family.

546269:HMPREF0389 RS06280
gene id: 546269:HMPREF0389_RS06280
uniprot id: D6GQ19
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS05865
gene id: 546269:HMPREF0389_RS05865
uniprot id: D6GPT4
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

546269:HMPREF0389 RS00065
gene id: 546269:HMPREF0389_RS00065
uniprot id: D6GSU7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

546269:HMPREF0389 RS05405
gene id: 546269:HMPREF0389_RS05405
uniprot id: D6GPJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

546269:HMPREF0389 RS01130
gene id: 546269:HMPREF0389_RS01130
uniprot id: D6GS50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

546269:HMPREF0389 RS05170
gene id: 546269:HMPREF0389_RS05170
uniprot id: D6GSL2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

546269:HMPREF0389 RS01225
gene id: 546269:HMPREF0389_RS01225
uniprot id: D6GS31
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

546269:HMPREF0389 RS03505
gene id: 546269:HMPREF0389_RS03505
uniprot id: D6GU36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

546269:HMPREF0389 RS07675
gene id: 546269:HMPREF0389_RS07675
uniprot id: D6GQV0
names: Similarity
messages: Belongs to the ArsC family.

546269:HMPREF0389 RS00695
gene id: 546269:HMPREF0389_RS00695
uniprot id: D6GSD5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

546269:HMPREF0389 RS05290
gene id: 546269:HMPREF0389_RS05290
uniprot id: D6GSN6
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

546269:HMPREF0389 RS06655
gene id: 546269:HMPREF0389_RS06655
uniprot id: D6GQ95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

546269:HMPREF0389 RS01360
gene id: 546269:HMPREF0389_RS01360
uniprot id: D6GS04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

546269:HMPREF0389 RS01775
gene id: 546269:HMPREF0389_RS01775
uniprot id: D6GRS0
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS04185
gene id: 546269:HMPREF0389_RS04185
uniprot id: D6GTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

546269:HMPREF0389 RS07335
gene id: 546269:HMPREF0389_RS07335
uniprot id: D6GQN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

546269:HMPREF0389 RS02675
gene id: 546269:HMPREF0389_RS02675
uniprot id: D6GR96
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

546269:HMPREF0389 RS04265
gene id: 546269:HMPREF0389_RS04265
uniprot id: D6GTP4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

546269:HMPREF0389 RS01190
gene id: 546269:HMPREF0389_RS01190
uniprot id: D6GS38
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

546269:HMPREF0389 RS03250
gene id: 546269:HMPREF0389_RS03250
uniprot id: D6GU64
names: Similarity
messages: Belongs to the Dps family.

546269:HMPREF0389 RS07250
gene id: 546269:HMPREF0389_RS07250
uniprot id: D6GQL7
names: Similarity
messages: Belongs to the UPF0597 family.

546269:HMPREF0389 RS06420
gene id: 546269:HMPREF0389_RS06420
uniprot id: D6GQ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

546269:HMPREF0389 RS07875
gene id: 546269:HMPREF0389_RS07875
uniprot id: D6GQY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS02620
gene id: 546269:HMPREF0389_RS02620
uniprot id: D6GRA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

546269:HMPREF0389 RS03565
gene id: 546269:HMPREF0389_RS03565
uniprot id: D6GU24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

546269:HMPREF0389 RS05745
gene id: 546269:HMPREF0389_RS05745
uniprot id: D6GPQ8
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

546269:HMPREF0389 RS02690
gene id: 546269:HMPREF0389_RS02690
uniprot id: D6GR93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

546269:HMPREF0389 RS08100
gene id: 546269:HMPREF0389_RS08100
uniprot id: D6GT67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

546269:HMPREF0389 RS05800
gene id: 546269:HMPREF0389_RS05800
uniprot id: D6GPS1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Belongs to the RNase PH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

546269:HMPREF0389 RS07130
gene id: 546269:HMPREF0389_RS07130
uniprot id: D6GQJ0
names: Similarity
messages: Belongs to the UPF0473 family.

546269:HMPREF0389 RS00585
gene id: 546269:HMPREF0389_RS00585
uniprot id: D6GSF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

546269:HMPREF0389 RS02685
gene id: 546269:HMPREF0389_RS02685
uniprot id: D6GR94
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

546269:HMPREF0389 RS06105
gene id: 546269:HMPREF0389_RS06105
uniprot id: D6GPY4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

546269:HMPREF0389 RS05585
gene id: 546269:HMPREF0389_RS05585
uniprot id: D6GPM8
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS00885
gene id: 546269:HMPREF0389_RS00885
uniprot id: D6GS97
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

546269:HMPREF0389 RS06985
gene id: 546269:HMPREF0389_RS06985
uniprot id: D6GQG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

546269:HMPREF0389 RS06630
gene id: 546269:HMPREF0389_RS06630
uniprot id: D6GQ90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

546269:HMPREF0389 RS04180
gene id: 546269:HMPREF0389_RS04180
uniprot id: D6GTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

546269:HMPREF0389 RS06710
gene id: 546269:HMPREF0389_RS06710
uniprot id: D6GQA6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

546269:HMPREF0389 RS08455
gene id: 546269:HMPREF0389_RS08455
uniprot id: D6GSZ8
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS03000
gene id: 546269:HMPREF0389_RS03000
uniprot id: D6GR32
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS06450
gene id: 546269:HMPREF0389_RS06450
uniprot id: D6GQ54
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

546269:HMPREF0389 RS01470
gene id: 546269:HMPREF0389_RS01470
uniprot id: D6GRY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

546269:HMPREF0389 RS06640
gene id: 546269:HMPREF0389_RS06640
uniprot id: D6GQ92
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

546269:HMPREF0389 RS08105
gene id: 546269:HMPREF0389_RS08105
uniprot id: D6GT66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

546269:HMPREF0389 RS03075
gene id: 546269:HMPREF0389_RS03075
uniprot id: D6GR17
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01035
gene id: 546269:HMPREF0389_RS01035
uniprot id: D6GS70
names: Similarity
messages: Belongs to the GSP E family.

546269:HMPREF0389 RS01645
gene id: 546269:HMPREF0389_RS01645
uniprot id: D6GRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

546269:HMPREF0389 RS03725
gene id: 546269:HMPREF0389_RS03725
uniprot id: D6GTZ3
names: Similarity
messages: Belongs to the FBPase class 2 family.

546269:HMPREF0389 RS05675
gene id: 546269:HMPREF0389_RS05675
uniprot id: D6GPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

546269:HMPREF0389 RS04015
gene id: 546269:HMPREF0389_RS04015
uniprot id: D6GTT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS04645
gene id: 546269:HMPREF0389_RS04645
uniprot id: D6GTG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

546269:HMPREF0389 RS03595
gene id: 546269:HMPREF0389_RS03595
uniprot id: D6GU18
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

546269:HMPREF0389 RS05070
gene id: 546269:HMPREF0389_RS05070
uniprot id: E8RKB1
names: Similarity
messages: Belongs to the Dps family.

546269:HMPREF0389 RS01230
gene id: 546269:HMPREF0389_RS01230
uniprot id: D6GS30
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS01730
gene id: 546269:HMPREF0389_RS01730
uniprot id: D6GRT0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

546269:HMPREF0389 RS00665
gene id: 546269:HMPREF0389_RS00665
uniprot id: D6GSE1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

546269:HMPREF0389 RS03645
gene id: 546269:HMPREF0389_RS03645
uniprot id: D6GU08
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS08540
gene id: 546269:HMPREF0389_RS08540
uniprot id: D6GSY1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

546269:HMPREF0389 RS04290
gene id: 546269:HMPREF0389_RS04290
uniprot id: E8RKA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

546269:HMPREF0389 RS05575
gene id: 546269:HMPREF0389_RS05575
uniprot id: D6GPM6
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06700
gene id: 546269:HMPREF0389_RS06700
uniprot id: D6GQA4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

546269:HMPREF0389 RS05145
gene id: 546269:HMPREF0389_RS05145
uniprot id: D6GSK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

546269:HMPREF0389 RS07795
gene id: 546269:HMPREF0389_RS07795
uniprot id: D6GQX3
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS00790
gene id: 546269:HMPREF0389_RS00790
uniprot id: D6GSB6
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

546269:HMPREF0389 RS06800
gene id: 546269:HMPREF0389_RS06800
uniprot id: D6GQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

546269:HMPREF0389 RS08115
gene id: 546269:HMPREF0389_RS08115
uniprot id: D6GT64
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

546269:HMPREF0389 RS04725
gene id: 546269:HMPREF0389_RS04725
uniprot id: D6GTF2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

546269:HMPREF0389 RS03530
gene id: 546269:HMPREF0389_RS03530
uniprot id: D6GU31
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

546269:HMPREF0389 RS08110
gene id: 546269:HMPREF0389_RS08110
uniprot id: D6GT65
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

546269:HMPREF0389 RS06405
gene id: 546269:HMPREF0389_RS06405
uniprot id: D6GQ46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

546269:HMPREF0389 RS05365
gene id: 546269:HMPREF0389_RS05365
uniprot id: D6GPI8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

546269:HMPREF0389 RS02640
gene id: 546269:HMPREF0389_RS02640
uniprot id: D6GRA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

546269:HMPREF0389 RS03280
gene id: 546269:HMPREF0389_RS03280
uniprot id: D6GU58
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

546269:HMPREF0389 RS02520
gene id: 546269:HMPREF0389_RS02520
uniprot id: D6GRC7
names: Similarity
messages: Belongs to the UPF0102 family.

546269:HMPREF0389 RS06370
gene id: 546269:HMPREF0389_RS06370
uniprot id: D6GQ39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

546269:HMPREF0389 RS01545
gene id: 546269:HMPREF0389_RS01545
uniprot id: D6GRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

546269:HMPREF0389 RS05760
gene id: 546269:HMPREF0389_RS05760
uniprot id: D6GPR2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

546269:HMPREF0389 RS00020
gene id: 546269:HMPREF0389_RS00020
uniprot id: D6GSV6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

546269:HMPREF0389 RS06250
gene id: 546269:HMPREF0389_RS06250
uniprot id: D6GQ13
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

546269:HMPREF0389 RS05095
gene id: 546269:HMPREF0389_RS05095
uniprot id: D6GU59
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

546269:HMPREF0389 RS00785
gene id: 546269:HMPREF0389_RS00785
uniprot id: D6GSB7
names: Similarity
messages: Belongs to the glutamine synthetase family.

546269:HMPREF0389 RS06445
gene id: 546269:HMPREF0389_RS06445
uniprot id: D6GQ53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

546269:HMPREF0389 RS03730
gene id: 546269:HMPREF0389_RS03730
uniprot id: D6GTZ2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

546269:HMPREF0389 RS05785
gene id: 546269:HMPREF0389_RS05785
uniprot id: D6GPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS07770
gene id: 546269:HMPREF0389_RS07770
uniprot id: D6GQX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

546269:HMPREF0389 RS00060
gene id: 546269:HMPREF0389_RS00060
uniprot id: D6GSU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

546269:HMPREF0389 RS05280
gene id: 546269:HMPREF0389_RS05280
uniprot id: D6GSN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

546269:HMPREF0389 RS00425
gene id: 546269:HMPREF0389_RS00425
uniprot id: D6GSI9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

546269:HMPREF0389 RS01585
gene id: 546269:HMPREF0389_RS01585
uniprot id: D6GRW0
names: Similarity
messages: Belongs to the GSP E family.

546269:HMPREF0389 RS07010
gene id: 546269:HMPREF0389_RS07010
uniprot id: D6GQG5
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

546269:HMPREF0389 RS07935
gene id: 546269:HMPREF0389_RS07935
uniprot id: D6GTA2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

546269:HMPREF0389 RS04470
gene id: 546269:HMPREF0389_RS04470
uniprot id: D6GTK4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

546269:HMPREF0389 RS03360
gene id: 546269:HMPREF0389_RS03360
uniprot id: E8RK94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

546269:HMPREF0389 RS07140
gene id: 546269:HMPREF0389_RS07140
uniprot id: D6GQJ2
names: Similarity
messages: Belongs to the UPF0297 family.

546269:HMPREF0389 RS05980
gene id: 546269:HMPREF0389_RS05980
uniprot id: D6GPW0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

546269:HMPREF0389 RS02795
gene id: 546269:HMPREF0389_RS02795
uniprot id: D6GR73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS05310
gene id: 546269:HMPREF0389_RS05310
uniprot id: D6GPH8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

546269:HMPREF0389 RS06775
gene id: 546269:HMPREF0389_RS06775
uniprot id: D6GQB9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

546269:HMPREF0389 RS03220
gene id: 546269:HMPREF0389_RS03220
uniprot id: D6GU70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

546269:HMPREF0389 RS01480
gene id: 546269:HMPREF0389_RS01480
uniprot id: D6GRY1
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

546269:HMPREF0389 RS06470
gene id: 546269:HMPREF0389_RS06470
uniprot id: D6GQ58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

546269:HMPREF0389 RS06815
gene id: 546269:HMPREF0389_RS06815
uniprot id: D6GQC7
names: Similarity
messages: Belongs to the asparaginase 1 family.

546269:HMPREF0389 RS00545
gene id: 546269:HMPREF0389_RS00545
uniprot id: D6GSG5
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

546269:HMPREF0389 RS03985
gene id: 546269:HMPREF0389_RS03985
uniprot id: D6GTU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS00120
gene id: 546269:HMPREF0389_RS00120
uniprot id: D6GST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

546269:HMPREF0389 RS07005
gene id: 546269:HMPREF0389_RS07005
uniprot id: D6GQG4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

546269:HMPREF0389 RS06000
gene id: 546269:HMPREF0389_RS06000
uniprot id: D6GPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS01330
gene id: 546269:HMPREF0389_RS01330
uniprot id: D6GS10
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

546269:HMPREF0389 RS06525
gene id: 546269:HMPREF0389_RS06525
uniprot id: D6GQ69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

546269:HMPREF0389 RS04275
gene id: 546269:HMPREF0389_RS04275
uniprot id: D6GTP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gmhB family.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS02840
gene id: 546269:HMPREF0389_RS02840
uniprot id: D6GR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

546269:HMPREF0389 RS04200
gene id: 546269:HMPREF0389_RS04200
uniprot id: D6GTQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

546269:HMPREF0389 RS08450
gene id: 546269:HMPREF0389_RS08450
uniprot id: D6GSZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

546269:HMPREF0389 RS02705
gene id: 546269:HMPREF0389_RS02705
uniprot id: D6GR90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

546269:HMPREF0389 RS02120
gene id: 546269:HMPREF0389_RS02120
uniprot id: D6GRK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

546269:HMPREF0389 RS01900
gene id: 546269:HMPREF0389_RS01900
uniprot id: D6GRQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS02320
gene id: 546269:HMPREF0389_RS02320
uniprot id: D6GRG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

546269:HMPREF0389 RS03720
gene id: 546269:HMPREF0389_RS03720
uniprot id: D6GTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

546269:HMPREF0389 RS02050
gene id: 546269:HMPREF0389_RS02050
uniprot id: D6GRM1
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS04650
gene id: 546269:HMPREF0389_RS04650
uniprot id: D6GTG7
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

546269:HMPREF0389 RS04205
gene id: 546269:HMPREF0389_RS04205
uniprot id: D6GTQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

546269:HMPREF0389 RS07270
gene id: 546269:HMPREF0389_RS07270
uniprot id: D6GQM1
names: Similarity
messages: Belongs to the peptidase C69 family.

546269:HMPREF0389 RS05590
gene id: 546269:HMPREF0389_RS05590
uniprot id: D6GPM9
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06245
gene id: 546269:HMPREF0389_RS06245
uniprot id: D6GQ12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

546269:HMPREF0389 RS07535
gene id: 546269:HMPREF0389_RS07535
uniprot id: D6GQS4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

546269:HMPREF0389 RS07220
gene id: 546269:HMPREF0389_RS07220
uniprot id: D6GQK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

546269:HMPREF0389 RS06990
gene id: 546269:HMPREF0389_RS06990
uniprot id: D6GQG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

546269:HMPREF0389 RS07625
gene id: 546269:HMPREF0389_RS07625
uniprot id: D6GQU1
names: Similarity
messages: Belongs to the YggT family.

546269:HMPREF0389 RS04940
gene id: 546269:HMPREF0389_RS04940
uniprot id: D6GTA6
names: Similarity
messages: Belongs to the peptidase C40 family.

546269:HMPREF0389 RS04310
gene id: 546269:HMPREF0389_RS04310
uniprot id: D6GTN6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

546269:HMPREF0389 RS06360
gene id: 546269:HMPREF0389_RS06360
uniprot id: D6GQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

546269:HMPREF0389 RS02810
gene id: 546269:HMPREF0389_RS02810
uniprot id: D6GR70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

546269:HMPREF0389 RS01700
gene id: 546269:HMPREF0389_RS01700
uniprot id: D6GRT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

546269:HMPREF0389 RS00960
gene id: 546269:HMPREF0389_RS00960
uniprot id: D6GS83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

546269:HMPREF0389 RS06140
gene id: 546269:HMPREF0389_RS06140
uniprot id: E8RK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

546269:HMPREF0389 RS02645
gene id: 546269:HMPREF0389_RS02645
uniprot id: D6GRA2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS02765
gene id: 546269:HMPREF0389_RS02765
uniprot id: D6GR79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

546269:HMPREF0389 RS00810
gene id: 546269:HMPREF0389_RS00810
uniprot id: D6GSB2
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

546269:HMPREF0389 RS00735
gene id: 546269:HMPREF0389_RS00735
uniprot id: D6GSC8
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

546269:HMPREF0389 RS04895
gene id: 546269:HMPREF0389_RS04895
uniprot id: D6GTB6
names: Similarity
messages: Belongs to the DDAH family.

546269:HMPREF0389 RS02605
gene id: 546269:HMPREF0389_RS02605
uniprot id: D6GRB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS08245
gene id: 546269:HMPREF0389_RS08245
uniprot id: D6GT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

546269:HMPREF0389 RS07120
gene id: 546269:HMPREF0389_RS07120
uniprot id: D6GQI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

546269:HMPREF0389 RS08525
gene id: 546269:HMPREF0389_RS08525
uniprot id: D6GSY4
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01630
gene id: 546269:HMPREF0389_RS01630
uniprot id: D6GRV1
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS05720
gene id: 546269:HMPREF0389_RS05720
uniprot id: D6GPQ3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

546269:HMPREF0389 RS06650
gene id: 546269:HMPREF0389_RS06650
uniprot id: D6GQ94
names: Similarity
messages: Belongs to the asp23 family.

546269:HMPREF0389 RS02565
gene id: 546269:HMPREF0389_RS02565
uniprot id: D6GRB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

546269:HMPREF0389 RS02715
gene id: 546269:HMPREF0389_RS02715
uniprot id: D6GR88
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

546269:HMPREF0389 RS05275
gene id: 546269:HMPREF0389_RS05275
uniprot id: D6GSN3
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

546269:HMPREF0389 RS01765
gene id: 546269:HMPREF0389_RS01765
uniprot id: D6GRS3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

546269:HMPREF0389 RS08165
gene id: 546269:HMPREF0389_RS08165
uniprot id: D6GT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

546269:HMPREF0389 RS05970
gene id: 546269:HMPREF0389_RS05970
uniprot id: D6GPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

546269:HMPREF0389 RS06385
gene id: 546269:HMPREF0389_RS06385
uniprot id: D6GQ42
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

546269:HMPREF0389 RS08485
gene id: 546269:HMPREF0389_RS08485
uniprot id: D6GSZ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS01335
gene id: 546269:HMPREF0389_RS01335
uniprot id: D6GS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

546269:HMPREF0389 RS00550
gene id: 546269:HMPREF0389_RS00550
uniprot id: D6GSG4
names: Similarity
messages: Belongs to the peptidase S41A family.

546269:HMPREF0389 RS02730
gene id: 546269:HMPREF0389_RS02730
uniprot id: D6GR85
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

546269:HMPREF0389 RS07305
gene id: 546269:HMPREF0389_RS07305
uniprot id: D6GQM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

546269:HMPREF0389 RS07790
gene id: 546269:HMPREF0389_RS07790
uniprot id: D6GQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS06040
gene id: 546269:HMPREF0389_RS06040
uniprot id: D6GPX3
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

546269:HMPREF0389 RS03495
gene id: 546269:HMPREF0389_RS03495
uniprot id: D6GU38
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

546269:HMPREF0389 RS06960
gene id: 546269:HMPREF0389_RS06960
uniprot id: D6GQF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

546269:HMPREF0389 RS02540
gene id: 546269:HMPREF0389_RS02540
uniprot id: D6GRC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

546269:HMPREF0389 RS02650
gene id: 546269:HMPREF0389_RS02650
uniprot id: D6GRA1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

546269:HMPREF0389 RS02965
gene id: 546269:HMPREF0389_RS02965
uniprot id: D6GR39
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

546269:HMPREF0389 RS00130
gene id: 546269:HMPREF0389_RS00130
uniprot id: D6GST4
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

546269:HMPREF0389 RS05900
gene id: 546269:HMPREF0389_RS05900
uniprot id: D6GPU1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

546269:HMPREF0389 RS00980
gene id: 546269:HMPREF0389_RS00980
uniprot id: E8RK71
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

546269:HMPREF0389 RS03065
gene id: 546269:HMPREF0389_RS03065
uniprot id: D6GR19
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06580
gene id: 546269:HMPREF0389_RS06580
uniprot id: D6GQ81
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

546269:HMPREF0389 RS07090
gene id: 546269:HMPREF0389_RS07090
uniprot id: D6GQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

546269:HMPREF0389 RS00070
gene id: 546269:HMPREF0389_RS00070
uniprot id: D6GSU6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

546269:HMPREF0389 RS03705
gene id: 546269:HMPREF0389_RS03705
uniprot id: D6GTZ7
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

546269:HMPREF0389 RS01490
gene id: 546269:HMPREF0389_RS01490
uniprot id: D6GRX9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

546269:HMPREF0389 RS04340
gene id: 546269:HMPREF0389_RS04340
uniprot id: D6GTN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS04455
gene id: 546269:HMPREF0389_RS04455
uniprot id: D6GTK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

546269:HMPREF0389 RS02535
gene id: 546269:HMPREF0389_RS02535
uniprot id: D6GRC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

546269:HMPREF0389 RS02860
gene id: 546269:HMPREF0389_RS02860
uniprot id: D6GR60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

546269:HMPREF0389 RS03290
gene id: 546269:HMPREF0389_RS03290
uniprot id: D6GU56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

546269:HMPREF0389 RS08310
gene id: 546269:HMPREF0389_RS08310
uniprot id: D6GT26
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

546269:HMPREF0389 RS04005
gene id: 546269:HMPREF0389_RS04005
uniprot id: D6GTT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS02935
gene id: 546269:HMPREF0389_RS02935
uniprot id: D6GR45
names: Similarity
messages: Belongs to the peptidase M18 family.

546269:HMPREF0389 RS00155
gene id: 546269:HMPREF0389_RS00155
uniprot id: D6GSS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

546269:HMPREF0389 RS01600
gene id: 546269:HMPREF0389_RS01600
uniprot id: D6GRV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

546269:HMPREF0389 RS06135
gene id: 546269:HMPREF0389_RS06135
uniprot id: D6GPZ0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

546269:HMPREF0389 RS06995
gene id: 546269:HMPREF0389_RS06995
uniprot id: D6GQG2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

546269:HMPREF0389 RS07615
gene id: 546269:HMPREF0389_RS07615
uniprot id: D6GQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS03885
gene id: 546269:HMPREF0389_RS03885
uniprot id: D6GTV8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

546269:HMPREF0389 RS01790
gene id: 546269:HMPREF0389_RS01790
uniprot id: D6GRR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

546269:HMPREF0389 RS06595
gene id: 546269:HMPREF0389_RS06595
uniprot id: D6GQ83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

546269:HMPREF0389 RS08400
gene id: 546269:HMPREF0389_RS08400
uniprot id: D6GT10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

546269:HMPREF0389 RS07240
gene id: 546269:HMPREF0389_RS07240
uniprot id: E8RK69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

546269:HMPREF0389 RS06365
gene id: 546269:HMPREF0389_RS06365
uniprot id: D6GQ38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

546269:HMPREF0389 RS01235
gene id: 546269:HMPREF0389_RS01235
uniprot id: D6GS29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

546269:HMPREF0389 RS03100
gene id: 546269:HMPREF0389_RS03100
uniprot id: D6GR11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

546269:HMPREF0389 RS01450
gene id: 546269:HMPREF0389_RS01450
uniprot id: D6GRY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS04655
gene id: 546269:HMPREF0389_RS04655
uniprot id: D6GTG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

546269:HMPREF0389 RS06560
gene id: 546269:HMPREF0389_RS06560
uniprot id: D6GQ77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

546269:HMPREF0389 RS03795
gene id: 546269:HMPREF0389_RS03795
uniprot id: D6GTX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

546269:HMPREF0389 RS00350
gene id: 546269:HMPREF0389_RS00350
uniprot id: D6GSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

546269:HMPREF0389 RS03050
gene id: 546269:HMPREF0389_RS03050
uniprot id: D6GR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

546269:HMPREF0389 RS07290
gene id: 546269:HMPREF0389_RS07290
uniprot id: D6GQM5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

546269:HMPREF0389 RS06505
gene id: 546269:HMPREF0389_RS06505
uniprot id: D6GQ65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

546269:HMPREF0389 RS03230
gene id: 546269:HMPREF0389_RS03230
uniprot id: D6GU68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

546269:HMPREF0389 RS06130
gene id: 546269:HMPREF0389_RS06130
uniprot id: D6GPY9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

546269:HMPREF0389 RS06095
gene id: 546269:HMPREF0389_RS06095
uniprot id: D6GPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

546269:HMPREF0389 RS00630
gene id: 546269:HMPREF0389_RS00630
uniprot id: D6GSE8
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

546269:HMPREF0389 RS01295
gene id: 546269:HMPREF0389_RS01295
uniprot id: D6GS17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

546269:HMPREF0389 RS04195
gene id: 546269:HMPREF0389_RS04195
uniprot id: D6GTQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

546269:HMPREF0389 RS05930
gene id: 546269:HMPREF0389_RS05930
uniprot id: D6GPU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

546269:HMPREF0389 RS03780
gene id: 546269:HMPREF0389_RS03780
uniprot id: D6GTY0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

546269:HMPREF0389 RS04685
gene id: 546269:HMPREF0389_RS04685
uniprot id: D6GTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

546269:HMPREF0389 RS06535
gene id: 546269:HMPREF0389_RS06535
uniprot id: D6GQ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

546269:HMPREF0389 RS01145
gene id: 546269:HMPREF0389_RS01145
uniprot id: D6GS47
names: Similarity
messages: Belongs to the peptidase C40 family.

546269:HMPREF0389 RS04910
gene id: 546269:HMPREF0389_RS04910
uniprot id: D6GTB3
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS03925
gene id: 546269:HMPREF0389_RS03925
uniprot id: D6GTV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

546269:HMPREF0389 RS05110
gene id: 546269:HMPREF0389_RS05110
uniprot id: E8RKB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

546269:HMPREF0389 RS06510
gene id: 546269:HMPREF0389_RS06510
uniprot id: D6GQ66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

546269:HMPREF0389 RS05820
gene id: 546269:HMPREF0389_RS05820
uniprot id: D6GPS5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS00395
gene id: 546269:HMPREF0389_RS00395
uniprot id: D6GSJ5
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

546269:HMPREF0389 RS06035
gene id: 546269:HMPREF0389_RS06035
uniprot id: D6GPX2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

546269:HMPREF0389 RS00560
gene id: 546269:HMPREF0389_RS00560
uniprot id: D6GSG2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

546269:HMPREF0389 RS04105
gene id: 546269:HMPREF0389_RS04105
uniprot id: D6GTR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

546269:HMPREF0389 RS03790
gene id: 546269:HMPREF0389_RS03790
uniprot id: D6GTX8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

546269:HMPREF0389 RS02850
gene id: 546269:HMPREF0389_RS02850
uniprot id: D6GR62
names: Similarity
messages: Belongs to the ycf81 family.

546269:HMPREF0389 RS03115
gene id: 546269:HMPREF0389_RS03115
uniprot id: D6GR09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

546269:HMPREF0389 RS07310
gene id: 546269:HMPREF0389_RS07310
uniprot id: D6GQM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

546269:HMPREF0389 RS07300
gene id: 546269:HMPREF0389_RS07300
uniprot id: D6GQM7
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

546269:HMPREF0389 RS05975
gene id: 546269:HMPREF0389_RS05975
uniprot id: E8RKC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

546269:HMPREF0389 RS06340
gene id: 546269:HMPREF0389_RS06340
uniprot id: D6GQ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS01355
gene id: 546269:HMPREF0389_RS01355
uniprot id: D6GS05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

546269:HMPREF0389 RS08145
gene id: 546269:HMPREF0389_RS08145
uniprot id: D6GT58
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

546269:HMPREF0389 RS00480
gene id: 546269:HMPREF0389_RS00480
uniprot id: D6GSH8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS08240
gene id: 546269:HMPREF0389_RS08240
uniprot id: D6GT39
names: Similarity
messages: Belongs to the UPF0423 family.

546269:HMPREF0389 RS06375
gene id: 546269:HMPREF0389_RS06375
uniprot id: D6GQ40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

546269:HMPREF0389 RS08660
gene id: 546269:HMPREF0389_RS08660
uniprot id: D6GSJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

546269:HMPREF0389 RS07545
gene id: 546269:HMPREF0389_RS07545
uniprot id: D6GQS6
names: Similarity
messages: Belongs to the HsdR family.

546269:HMPREF0389 RS06790
gene id: 546269:HMPREF0389_RS06790
uniprot id: D6GQC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS06565
gene id: 546269:HMPREF0389_RS06565
uniprot id: D6GQ78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

546269:HMPREF0389 RS06455
gene id: 546269:HMPREF0389_RS06455
uniprot id: D6GQ55
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

546269:HMPREF0389 RS00590
gene id: 546269:HMPREF0389_RS00590
uniprot id: D6GSF6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS06935
gene id: 546269:HMPREF0389_RS06935
uniprot id: D6GQF0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

546269:HMPREF0389 RS06540
gene id: 546269:HMPREF0389_RS06540
uniprot id: D6GQ72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

546269:HMPREF0389 RS02695
gene id: 546269:HMPREF0389_RS02695
uniprot id: D6GR92
names: Similarity
messages: Belongs to the DEAD box helicase family.

546269:HMPREF0389 RS00320
gene id: 546269:HMPREF0389_RS00320
uniprot id: D6GSP7
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS02305
gene id: 546269:HMPREF0389_RS02305
uniprot id: D6GRG8
names: Similarity
messages: Belongs to the MobA/MobL family.

546269:HMPREF0389 RS02560
gene id: 546269:HMPREF0389_RS02560
uniprot id: D6GRB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

546269:HMPREF0389 RS03880
gene id: 546269:HMPREF0389_RS03880
uniprot id: D6GTV9
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS08470
gene id: 546269:HMPREF0389_RS08470
uniprot id: D6GSZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS06520
gene id: 546269:HMPREF0389_RS06520
uniprot id: D6GQ68
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

546269:HMPREF0389 RS01495
gene id: 546269:HMPREF0389_RS01495
uniprot id: D6GRX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

546269:HMPREF0389 RS00400
gene id: 546269:HMPREF0389_RS00400
uniprot id: D6GSJ4
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

546269:HMPREF0389 RS01170
gene id: 546269:HMPREF0389_RS01170
uniprot id: D6GS42
names: Similarity
messages: Belongs to the UPF0237 family.

546269:HMPREF0389 RS07865
gene id: 546269:HMPREF0389_RS07865
uniprot id: D6GQY5
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

546269:HMPREF0389 RS06460
gene id: 546269:HMPREF0389_RS06460
uniprot id: D6GQ56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

546269:HMPREF0389 RS08125
gene id: 546269:HMPREF0389_RS08125
uniprot id: D6GT62
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

546269:HMPREF0389 RS04460
gene id: 546269:HMPREF0389_RS04460
uniprot id: D6GTK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

546269:HMPREF0389 RS03655
gene id: 546269:HMPREF0389_RS03655
uniprot id: D6GU06
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

546269:HMPREF0389 RS07115
gene id: 546269:HMPREF0389_RS07115
uniprot id: D6GQI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS04390
gene id: 546269:HMPREF0389_RS04390
uniprot id: D6GTM0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS06160
gene id: 546269:HMPREF0389_RS06160
uniprot id: E8RKD2
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

546269:HMPREF0389 RS01485
gene id: 546269:HMPREF0389_RS01485
uniprot id: D6GRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

546269:HMPREF0389 RS04610
gene id: 546269:HMPREF0389_RS04610
uniprot id: D6GTH5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

546269:HMPREF0389 RS05160
gene id: 546269:HMPREF0389_RS05160
uniprot id: D6GSL0
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS01015
gene id: 546269:HMPREF0389_RS01015
uniprot id: D6GS74
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

546269:HMPREF0389 RS07415
gene id: 546269:HMPREF0389_RS07415
uniprot id: D6GQQ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

546269:HMPREF0389 RS01595
gene id: 546269:HMPREF0389_RS01595
uniprot id: D6GRV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

546269:HMPREF0389 RS01965
gene id: 546269:HMPREF0389_RS01965
uniprot id: D6GRN7
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

546269:HMPREF0389 RS06575
gene id: 546269:HMPREF0389_RS06575
uniprot id: D6GQ80
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

546269:HMPREF0389 RS03315
gene id: 546269:HMPREF0389_RS03315
uniprot id: D6GU51
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS01910
gene id: 546269:HMPREF0389_RS01910
uniprot id: D6GRP8
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS03995
gene id: 546269:HMPREF0389_RS03995
uniprot id: E8RKA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS00805
gene id: 546269:HMPREF0389_RS00805
uniprot id: D6GSB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS05085
gene id: 546269:HMPREF0389_RS05085
uniprot id: D6GU61
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS04375
gene id: 546269:HMPREF0389_RS04375
uniprot id: D6GTM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

546269:HMPREF0389 RS07590
gene id: 546269:HMPREF0389_RS07590
uniprot id: D6GQT5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

546269:HMPREF0389 RS00485
gene id: 546269:HMPREF0389_RS00485
uniprot id: D6GSH7
names: Similarity
messages: Belongs to the carbamate kinase family.

546269:HMPREF0389 RS04380
gene id: 546269:HMPREF0389_RS04380
uniprot id: D6GTM2
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01625
gene id: 546269:HMPREF0389_RS01625
uniprot id: D6GRV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS00710
gene id: 546269:HMPREF0389_RS00710
uniprot id: D6GSD1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

546269:HMPREF0389 RS01525
gene id: 546269:HMPREF0389_RS01525
uniprot id: D6GRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

546269:HMPREF0389 RS04395
gene id: 546269:HMPREF0389_RS04395
uniprot id: D6GTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

546269:HMPREF0389 RS02380
gene id: 546269:HMPREF0389_RS02380
uniprot id: D6GRF3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

546269:HMPREF0389 RS02910
gene id: 546269:HMPREF0389_RS02910
uniprot id: D6GR50
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

546269:HMPREF0389 RS03680
gene id: 546269:HMPREF0389_RS03680
uniprot id: D6GU01
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01725
gene id: 546269:HMPREF0389_RS01725
uniprot id: D6GRT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

546269:HMPREF0389 RS01760
gene id: 546269:HMPREF0389_RS01760
uniprot id: D6GRS4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

546269:HMPREF0389 RS07955
gene id: 546269:HMPREF0389_RS07955
uniprot id: D6GT98
names: Subcellular Location Annotation
messages: cell wall

546269:HMPREF0389 RS01205
gene id: 546269:HMPREF0389_RS01205
uniprot id: D6GS35
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

546269:HMPREF0389 RS08060
gene id: 546269:HMPREF0389_RS08060
uniprot id: D6GT75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

546269:HMPREF0389 RS07025
gene id: 546269:HMPREF0389_RS07025
uniprot id: D6GQG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

546269:HMPREF0389 RS08130
gene id: 546269:HMPREF0389_RS08130
uniprot id: D6GT61
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

546269:HMPREF0389 RS00015
gene id: 546269:HMPREF0389_RS00015
uniprot id: D6GSV7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

546269:HMPREF0389 RS01615
gene id: 546269:HMPREF0389_RS01615
uniprot id: D6GRV4
names: Similarity
messages: Belongs to the UPF0749 family.

546269:HMPREF0389 RS00620
gene id: 546269:HMPREF0389_RS00620
uniprot id: D6GSF0
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

546269:HMPREF0389 RS06620
gene id: 546269:HMPREF0389_RS06620
uniprot id: D6GQ88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS02365
gene id: 546269:HMPREF0389_RS02365
uniprot id: D6GRF6
names: Similarity
messages: Belongs to the MobA/MobL family.

546269:HMPREF0389 RS01000
gene id: 546269:HMPREF0389_RS01000
uniprot id: D6GS77
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

546269:HMPREF0389 RS00825
gene id: 546269:HMPREF0389_RS00825
uniprot id: D6GSA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS06120
gene id: 546269:HMPREF0389_RS06120
uniprot id: D6GPY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

546269:HMPREF0389 RS02545
gene id: 546269:HMPREF0389_RS02545
uniprot id: D6GRC2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

546269:HMPREF0389 RS03575
gene id: 546269:HMPREF0389_RS03575
uniprot id: D6GU22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS03870
gene id: 546269:HMPREF0389_RS03870
uniprot id: D6GTW1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

546269:HMPREF0389 RS01405
gene id: 546269:HMPREF0389_RS01405
uniprot id: D6GRZ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS06980
gene id: 546269:HMPREF0389_RS06980
uniprot id: D6GQF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

546269:HMPREF0389 RS08595
gene id: 546269:HMPREF0389_RS08595
uniprot id: D6GSX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

546269:HMPREF0389 RS06545
gene id: 546269:HMPREF0389_RS06545
uniprot id: D6GQ73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

546269:HMPREF0389 RS05055
gene id: 546269:HMPREF0389_RS05055
uniprot id: D6GU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

546269:HMPREF0389 RS07710
gene id: 546269:HMPREF0389_RS07710
uniprot id: D6GQV6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS06950
gene id: 546269:HMPREF0389_RS06950
uniprot id: D6GQF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

546269:HMPREF0389 RS03905
gene id: 546269:HMPREF0389_RS03905
uniprot id: D6GTV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

546269:HMPREF0389 RS05990
gene id: 546269:HMPREF0389_RS05990
uniprot id: D6GPW2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

546269:HMPREF0389 RS00005
gene id: 546269:HMPREF0389_RS00005
uniprot id: D6GSV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

546269:HMPREF0389 RS02900
gene id: 546269:HMPREF0389_RS02900
uniprot id: D6GR52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS02250
gene id: 546269:HMPREF0389_RS02250
uniprot id: D6GRH9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

546269:HMPREF0389 RS04410
gene id: 546269:HMPREF0389_RS04410
uniprot id: D6GTL6
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01800
gene id: 546269:HMPREF0389_RS01800
uniprot id: D6GRR5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS08305
gene id: 546269:HMPREF0389_RS08305
uniprot id: D6GT27
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

546269:HMPREF0389 RS00515
gene id: 546269:HMPREF0389_RS00515
uniprot id: D6GSH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

546269:HMPREF0389 RS06905
gene id: 546269:HMPREF0389_RS06905
uniprot id: D6GQE4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS06805
gene id: 546269:HMPREF0389_RS06805
uniprot id: D6GQC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

546269:HMPREF0389 RS01370
gene id: 546269:HMPREF0389_RS01370
uniprot id: D6GS02
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

546269:HMPREF0389 RS04495
gene id: 546269:HMPREF0389_RS04495
uniprot id: D6GTJ9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

546269:HMPREF0389 RS06255
gene id: 546269:HMPREF0389_RS06255
uniprot id: D6GQ14
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

546269:HMPREF0389 RS06495
gene id: 546269:HMPREF0389_RS06495
uniprot id: D6GQ63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

546269:HMPREF0389 RS07595
gene id: 546269:HMPREF0389_RS07595
uniprot id: D6GQT6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

546269:HMPREF0389 RS08155
gene id: 546269:HMPREF0389_RS08155
uniprot id: D6GT56
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS03310
gene id: 546269:HMPREF0389_RS03310
uniprot id: D6GU52
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

546269:HMPREF0389 RS04820
gene id: 546269:HMPREF0389_RS04820
uniprot id: D6GTD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

546269:HMPREF0389 RS06060
gene id: 546269:HMPREF0389_RS06060
uniprot id: D6GPX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

546269:HMPREF0389 RS00355
gene id: 546269:HMPREF0389_RS00355
uniprot id: D6GSP0
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS05945
gene id: 546269:HMPREF0389_RS05945
uniprot id: D6GPV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

546269:HMPREF0389 RS05260
gene id: 546269:HMPREF0389_RS05260
uniprot id: D6GSN0
names: Similarity
messages: Belongs to the RutC family.

546269:HMPREF0389 RS08340
gene id: 546269:HMPREF0389_RS08340
uniprot id: D6GT20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

546269:HMPREF0389 RS01500
gene id: 546269:HMPREF0389_RS01500
uniprot id: D6GRX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

546269:HMPREF0389 RS08600
gene id: 546269:HMPREF0389_RS08600
uniprot id: D6GSW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

546269:HMPREF0389 RS01785
gene id: 546269:HMPREF0389_RS01785
uniprot id: D6GRR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

546269:HMPREF0389 RS00415
gene id: 546269:HMPREF0389_RS00415
uniprot id: D6GSJ1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

546269:HMPREF0389 RS02495
gene id: 546269:HMPREF0389_RS02495
uniprot id: D6GRD3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS08670
gene id: 546269:HMPREF0389_RS08670
uniprot id: D6GS96
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

546269:HMPREF0389 RS02660
gene id: 546269:HMPREF0389_RS02660
uniprot id: D6GR99
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

546269:HMPREF0389 RS08140
gene id: 546269:HMPREF0389_RS08140
uniprot id: D6GT59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

546269:HMPREF0389 RS01305
gene id: 546269:HMPREF0389_RS01305
uniprot id: D6GS15
names: Similarity
messages: Belongs to the UPF0735 family.

546269:HMPREF0389 RS00160
gene id: 546269:HMPREF0389_RS00160
uniprot id: D6GSS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

546269:HMPREF0389 RS05830
gene id: 546269:HMPREF0389_RS05830
uniprot id: D6GPS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

546269:HMPREF0389 RS01135
gene id: 546269:HMPREF0389_RS01135
uniprot id: D6GS49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

546269:HMPREF0389 RS01005
gene id: 546269:HMPREF0389_RS01005
uniprot id: D6GS76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

546269:HMPREF0389 RS02455
gene id: 546269:HMPREF0389_RS02455
uniprot id: D6GRE0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

546269:HMPREF0389 RS01430
gene id: 546269:HMPREF0389_RS01430
uniprot id: D6GRZ1
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

546269:HMPREF0389 RS08580
gene id: 546269:HMPREF0389_RS08580
uniprot id: D6GSX3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS00895
gene id: 546269:HMPREF0389_RS00895
uniprot id: D6GS95
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

546269:HMPREF0389 RS02330
gene id: 546269:HMPREF0389_RS02330
uniprot id: D6GRG3
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS00085
gene id: 546269:HMPREF0389_RS00085
uniprot id: D6GSU3
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

546269:HMPREF0389 RS00625
gene id: 546269:HMPREF0389_RS00625
uniprot id: D6GSE9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

546269:HMPREF0389 RS03095
gene id: 546269:HMPREF0389_RS03095
uniprot id: D6GR12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

546269:HMPREF0389 RS00605
gene id: 546269:HMPREF0389_RS00605
uniprot id: D6GSF3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

546269:HMPREF0389 RS06515
gene id: 546269:HMPREF0389_RS06515
uniprot id: D6GQ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

546269:HMPREF0389 RS01280
gene id: 546269:HMPREF0389_RS01280
uniprot id: D6GS20
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

546269:HMPREF0389 RS02165
gene id: 546269:HMPREF0389_RS02165
uniprot id: D6GRJ6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS03265
gene id: 546269:HMPREF0389_RS03265
uniprot id: D6GU61
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS08815
gene id: 546269:HMPREF0389_RS08815
uniprot id: E8RK80
names: Subcellular Location Annotation
messages: cell wall

546269:HMPREF0389 RS08795
gene id: 546269:HMPREF0389_RS08795
uniprot id: D6GQL2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

546269:HMPREF0389 RS06030
gene id: 546269:HMPREF0389_RS06030
uniprot id: D6GPX1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

546269:HMPREF0389 RS02780
gene id: 546269:HMPREF0389_RS02780
uniprot id: D6GR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS08445
gene id: 546269:HMPREF0389_RS08445
uniprot id: D6GT00
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS00920
gene id: 546269:HMPREF0389_RS00920
uniprot id: D6GS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

546269:HMPREF0389 RS01610
gene id: 546269:HMPREF0389_RS01610
uniprot id: D6GRV5
names: Similarity
messages: Belongs to the UPF0749 family.

546269:HMPREF0389 RS00405
gene id: 546269:HMPREF0389_RS00405
uniprot id: D6GSJ3
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS01795
gene id: 546269:HMPREF0389_RS01795
uniprot id: D6GRR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

546269:HMPREF0389 RS00800
gene id: 546269:HMPREF0389_RS00800
uniprot id: D6GSB4
names: Similarity
messages: Belongs to the RecJ family.

546269:HMPREF0389 RS05215
gene id: 546269:HMPREF0389_RS05215
uniprot id: D6GSM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

546269:HMPREF0389 RS08410
gene id: 546269:HMPREF0389_RS08410
uniprot id: D6GT08
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS05150
gene id: 546269:HMPREF0389_RS05150
uniprot id: D6GSK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS05185
gene id: 546269:HMPREF0389_RS05185
uniprot id: D6GSL5
names: Similarity
messages: Belongs to the peptidase S66 family.

546269:HMPREF0389 RS06600
gene id: 546269:HMPREF0389_RS06600
uniprot id: D6GQ84
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

546269:HMPREF0389 RS08645
gene id: 546269:HMPREF0389_RS08645
uniprot id: D6GSW1
names: Similarity
messages: Belongs to the peptidase S58 family.

546269:HMPREF0389 RS05895
gene id: 546269:HMPREF0389_RS05895
uniprot id: D6GPU0
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

546269:HMPREF0389 RS01520
gene id: 546269:HMPREF0389_RS01520
uniprot id: D6GRX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

546269:HMPREF0389 RS05635
gene id: 546269:HMPREF0389_RS05635
uniprot id: D6GPN8
names: Similarity
messages: Belongs to the peptidase C40 family.

546269:HMPREF0389 RS06475
gene id: 546269:HMPREF0389_RS06475
uniprot id: D6GQ59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

546269:HMPREF0389 RS00580
gene id: 546269:HMPREF0389_RS00580
uniprot id: D6GSF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

546269:HMPREF0389 RS02990
gene id: 546269:HMPREF0389_RS02990
uniprot id: D6GR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

546269:HMPREF0389 RS04190
gene id: 546269:HMPREF0389_RS04190
uniprot id: D6GTQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

546269:HMPREF0389 RS05330
gene id: 546269:HMPREF0389_RS05330
uniprot id: D6GPI2
names: Subcellular Location Annotation
messages: Cytoplasm

546269:HMPREF0389 RS08390
gene id: 546269:HMPREF0389_RS08390
uniprot id: D6GT12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

546269:HMPREF0389 RS04875
gene id: 546269:HMPREF0389_RS04875
uniprot id: D6GTC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

546269:HMPREF0389 RS03090
gene id: 546269:HMPREF0389_RS03090
uniprot id: E8RK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

546269:HMPREF0389 RS06115
gene id: 546269:HMPREF0389_RS06115
uniprot id: D6GPY6
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

546269:HMPREF0389 RS05255
gene id: 546269:HMPREF0389_RS05255
uniprot id: D6GSM9
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

546269:HMPREF0389 RS07275
gene id: 546269:HMPREF0389_RS07275
uniprot id: D6GQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

546269:HMPREF0389 RS05780
gene id: 546269:HMPREF0389_RS05780
uniprot id: D6GPR7
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

546269:HMPREF0389 RS07845
gene id: 546269:HMPREF0389_RS07845
uniprot id: D6GQY1
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

546269:HMPREF0389 RS01985
gene id: 546269:HMPREF0389_RS01985
uniprot id: D6GRN3
names: Similarity
messages: Belongs to the peptidase C40 family.

546269:HMPREF0389 RS02875
gene id: 546269:HMPREF0389_RS02875
uniprot id: D6GR57
names: Similarity
messages: Belongs to the YicC/YloC family.

546269:HMPREF0389 RS02950
gene id: 546269:HMPREF0389_RS02950
uniprot id: D6GR42
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

546269:HMPREF0389 RS02970
gene id: 546269:HMPREF0389_RS02970
uniprot id: D6GR38
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

546269:HMPREF0389 RS02740
gene id: 546269:HMPREF0389_RS02740
uniprot id: E8RK89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

546269:HMPREF0389 RS07050
gene id: 546269:HMPREF0389_RS07050
uniprot id: D6GQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

546269:HMPREF0389 RS04670
gene id: 546269:HMPREF0389_RS04670
uniprot id: D6GTG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

546269:HMPREF0389 RS02485
gene id: 546269:HMPREF0389_RS02485
uniprot id: D6GRD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

546269:HMPREF0389 RS05620
gene id: 546269:HMPREF0389_RS05620
uniprot id: D6GPN5
names: Similarity
messages: Belongs to the type IA topoisomerase family.

546269:HMPREF0389 RS01110
gene id: 546269:HMPREF0389_RS01110
uniprot id: D6GS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

546269:HMPREF0389 RS06440
gene id: 546269:HMPREF0389_RS06440
uniprot id: D6GQ52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

546269:HMPREF0389 RS06315
gene id: 546269:HMPREF0389_RS06315
uniprot id: D6GQ27
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS06240
gene id: 546269:HMPREF0389_RS06240
uniprot id: D6GQ11
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS04730
gene id: 546269:HMPREF0389_RS04730
uniprot id: D6GTF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

546269:HMPREF0389 RS02825
gene id: 546269:HMPREF0389_RS02825
uniprot id: D6GR67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

546269:HMPREF0389 RS05205
gene id: 546269:HMPREF0389_RS05205
uniprot id: D6GSL9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

546269:HMPREF0389 RS01640
gene id: 546269:HMPREF0389_RS01640
uniprot id: D6GRU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS04890
gene id: 546269:HMPREF0389_RS04890
uniprot id: D6GTB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS06865
gene id: 546269:HMPREF0389_RS06865
uniprot id: D6GQD7
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

546269:HMPREF0389 RS01410
gene id: 546269:HMPREF0389_RS01410
uniprot id: D6GRZ4
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS03235
gene id: 546269:HMPREF0389_RS03235
uniprot id: D6GU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

546269:HMPREF0389 RS07895
gene id: 546269:HMPREF0389_RS07895
uniprot id: D6GQZ1
names: Similarity
messages: Belongs to the UPF0473 family.

546269:HMPREF0389 RS00985
gene id: 546269:HMPREF0389_RS00985
uniprot id: D6GS80
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

546269:HMPREF0389 RS03810
gene id: 546269:HMPREF0389_RS03810
uniprot id: D6GTX4
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS02920
gene id: 546269:HMPREF0389_RS02920
uniprot id: D6GR48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

546269:HMPREF0389 RS00745
gene id: 546269:HMPREF0389_RS00745
uniprot id: D6GSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

546269:HMPREF0389 RS07755
gene id: 546269:HMPREF0389_RS07755
uniprot id: D6GQW6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS00370
gene id: 546269:HMPREF0389_RS00370
uniprot id: D6GSK0
names: Similarity
messages: Belongs to the UPF0758 family.

546269:HMPREF0389 RS02855
gene id: 546269:HMPREF0389_RS02855
uniprot id: D6GR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

546269:HMPREF0389 RS06965
gene id: 546269:HMPREF0389_RS06965
uniprot id: D6GQF6
names: Similarity
messages: Belongs to the fabD family.

546269:HMPREF0389 RS00995
gene id: 546269:HMPREF0389_RS00995
uniprot id: D6GS78
names: Similarity
messages: Belongs to the LacAB/RpiB family.

546269:HMPREF0389 RS08555
gene id: 546269:HMPREF0389_RS08555
uniprot id: D6GSX8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS00675
gene id: 546269:HMPREF0389_RS00675
uniprot id: D6GSD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

546269:HMPREF0389 RS07850
gene id: 546269:HMPREF0389_RS07850
uniprot id: D6GQY2
names: Similarity
messages: Belongs to the peptidase S8 family.

546269:HMPREF0389 RS03010
gene id: 546269:HMPREF0389_RS03010
uniprot id: D6GR30
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

546269:HMPREF0389 RS02680
gene id: 546269:HMPREF0389_RS02680
uniprot id: D6GR95
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

546269:HMPREF0389 RS04315
gene id: 546269:HMPREF0389_RS04315
uniprot id: D6GTN5
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

546269:HMPREF0389 RS08135
gene id: 546269:HMPREF0389_RS08135
uniprot id: D6GT60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

546269:HMPREF0389 RS00935
gene id: 546269:HMPREF0389_RS00935
uniprot id: D6GS88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

546269:HMPREF0389 RS03610
gene id: 546269:HMPREF0389_RS03610
uniprot id: D6GU15
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

546269:HMPREF0389 RS06760
gene id: 546269:HMPREF0389_RS06760
uniprot id: D6GQB6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

546269:HMPREF0389 RS05235
gene id: 546269:HMPREF0389_RS05235
uniprot id: D6GSM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

546269:HMPREF0389 RS00270
gene id: 546269:HMPREF0389_RS00270
uniprot id: D6GSQ6
names: Similarity
messages: Belongs to the EamA transporter family.

546269:HMPREF0389 RS00645
gene id: 546269:HMPREF0389_RS00645
uniprot id: D6GSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

546269:HMPREF0389 RS00430
gene id: 546269:HMPREF0389_RS00430
uniprot id: D6GSI8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

546269:HMPREF0389 RS06345
gene id: 546269:HMPREF0389_RS06345
uniprot id: D6GQ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS07480
gene id: 546269:HMPREF0389_RS07480
uniprot id: D6GQR5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

546269:HMPREF0389 RS00775
gene id: 546269:HMPREF0389_RS00775
uniprot id: D6GSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

546269:HMPREF0389 RS01180
gene id: 546269:HMPREF0389_RS01180
uniprot id: D6GS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

546269:HMPREF0389 RS05835
gene id: 546269:HMPREF0389_RS05835
uniprot id: D6GPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

546269:HMPREF0389 RS04365
gene id: 546269:HMPREF0389_RS04365
uniprot id: D6GTM5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

546269:HMPREF0389 RS01715
gene id: 546269:HMPREF0389_RS01715
uniprot id: D6GRT3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

546269:HMPREF0389 RS00380
gene id: 546269:HMPREF0389_RS00380
uniprot id: D6GSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

546269:HMPREF0389 RS03590
gene id: 546269:HMPREF0389_RS03590
uniprot id: D6GU19
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

546269:HMPREF0389 RS00595
gene id: 546269:HMPREF0389_RS00595
uniprot id: D6GSF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

546269:HMPREF0389 RS02930
gene id: 546269:HMPREF0389_RS02930
uniprot id: D6GR46
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

546269:HMPREF0389 RS01320
gene id: 546269:HMPREF0389_RS01320
uniprot id: D6GS12
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

546269:HMPREF0389 RS06885
gene id: 546269:HMPREF0389_RS06885
uniprot id: D6GQE1
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

546269:HMPREF0389 RS02460
gene id: 546269:HMPREF0389_RS02460
uniprot id: D6GRD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

546269:HMPREF0389 RS08625
gene id: 546269:HMPREF0389_RS08625
uniprot id: D6GSW4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

546269:HMPREF0389 RS04505
gene id: 546269:HMPREF0389_RS04505
uniprot id: D6GTJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

546269:HMPREF0389 RS07020
gene id: 546269:HMPREF0389_RS07020
uniprot id: D6GQG7
names: Similarity
messages: Belongs to the IMPACT family.

546269:HMPREF0389 RS01125
gene id: 546269:HMPREF0389_RS01125
uniprot id: D6GS51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

546269:HMPREF0389 RS01245
gene id: 546269:HMPREF0389_RS01245
uniprot id: D6GS27
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

546269:HMPREF0389 RS04500
gene id: 546269:HMPREF0389_RS04500
uniprot id: D6GTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

546269:HMPREF0389 RS00945
gene id: 546269:HMPREF0389_RS00945
uniprot id: D6GS86
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

546269:HMPREF0389 RS00510
gene id: 546269:HMPREF0389_RS00510
uniprot id: D6GSH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

546269:HMPREF0389 RS07635
gene id: 546269:HMPREF0389_RS07635
uniprot id: D6GQU3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

546269:HMPREF0389 RS01810
gene id: 546269:HMPREF0389_RS01810
uniprot id: D6GRR3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

546269:HMPREF0389 RS04240
gene id: 546269:HMPREF0389_RS04240
uniprot id: D6GTP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

546269:HMPREF0389 RS04415
gene id: 546269:HMPREF0389_RS04415
uniprot id: D6GTL5
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS07565
gene id: 546269:HMPREF0389_RS07565
uniprot id: D6GQT0
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS06940
gene id: 546269:HMPREF0389_RS06940
uniprot id: D6GQF1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

546269:HMPREF0389 RS00965
gene id: 546269:HMPREF0389_RS00965
uniprot id: D6GS82
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

546269:HMPREF0389 RS05740
gene id: 546269:HMPREF0389_RS05740
uniprot id: D6GPQ7
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

546269:HMPREF0389 RS08250
gene id: 546269:HMPREF0389_RS08250
uniprot id: D6GT37
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS04745
gene id: 546269:HMPREF0389_RS04745
uniprot id: D6GTE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

546269:HMPREF0389 RS00845
gene id: 546269:HMPREF0389_RS00845
uniprot id: D6GSA6
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

546269:HMPREF0389 RS01455
gene id: 546269:HMPREF0389_RS01455
uniprot id: D6GRY6
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

546269:HMPREF0389 RS01690
gene id: 546269:HMPREF0389_RS01690
uniprot id: D6GRT8
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS05130
gene id: 546269:HMPREF0389_RS05130
uniprot id: D6GSK4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

546269:HMPREF0389 RS07060
gene id: 546269:HMPREF0389_RS07060
uniprot id: D6GQH5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

546269:HMPREF0389 RS04520
gene id: 546269:HMPREF0389_RS04520
uniprot id: D6GTJ4
names: Similarity
messages: Belongs to the UPF0145 family.

546269:HMPREF0389 RS00990
gene id: 546269:HMPREF0389_RS00990
uniprot id: D6GS79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

546269:HMPREF0389 RS02760
gene id: 546269:HMPREF0389_RS02760
uniprot id: D6GR80
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

546269:HMPREF0389 RS06660
gene id: 546269:HMPREF0389_RS06660
uniprot id: D6GQ96
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

546269:HMPREF0389 RS01960
gene id: 546269:HMPREF0389_RS01960
uniprot id: D6GRN9
names: Similarity
messages: Belongs to the UPF0758 family.

546269:HMPREF0389 RS07455
gene id: 546269:HMPREF0389_RS07455
uniprot id: D6GQR0
names: Subcellular Location Annotation
messages: Membrane

546269:HMPREF0389 RS05175
gene id: 546269:HMPREF0389_RS05175
uniprot id: D6GSL3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

546269:HMPREF0389 RS00500
gene id: 546269:HMPREF0389_RS00500
uniprot id: D6GSH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

546269:HMPREF0389 RS05925
gene id: 546269:HMPREF0389_RS05925
uniprot id: D6GPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

546269:HMPREF0389 RS02610
gene id: 546269:HMPREF0389_RS02610
uniprot id: D6GRA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

546269:HMPREF0389 RS06485
gene id: 546269:HMPREF0389_RS06485
uniprot id: D6GQ61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.