529884:RHOLA RS06700
gene id: 529884:RHOLA_RS06700
uniprot id: A0A060JPT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

529884:RHOLA RS05985
gene id: 529884:RHOLA_RS05985
uniprot id: A0A060JHG9
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

529884:RHOLA RS00015
gene id: 529884:RHOLA_RS00015
uniprot id: A0A060JAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

529884:RHOLA RS03370
gene id: 529884:RHOLA_RS03370
uniprot id: A0A060JC79
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

529884:RHOLA RS05860
gene id: 529884:RHOLA_RS05860
uniprot id: A0A060JHE5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

529884:RHOLA RS03955
gene id: 529884:RHOLA_RS03955
uniprot id: A0A060JN03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

529884:RHOLA RS01540
gene id: 529884:RHOLA_RS01540
uniprot id: A0A060JBB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03045
gene id: 529884:RHOLA_RS03045
uniprot id: A0A060JME1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

529884:RHOLA RS04285
gene id: 529884:RHOLA_RS04285
uniprot id: A0A060JM82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

529884:RHOLA RS05815
gene id: 529884:RHOLA_RS05815
uniprot id: A0A060JP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS02290
gene id: 529884:RHOLA_RS02290
uniprot id: A0A060JEU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

529884:RHOLA RS03965
gene id: 529884:RHOLA_RS03965
uniprot id: A0A060JCM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

529884:RHOLA RS06045
gene id: 529884:RHOLA_RS06045
uniprot id: A0A060JP97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

529884:RHOLA RS01620
gene id: 529884:RHOLA_RS01620
uniprot id: A0A060JKQ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

529884:RHOLA RS01335
gene id: 529884:RHOLA_RS01335
uniprot id: A0A060JB61
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03665
gene id: 529884:RHOLA_RS03665
uniprot id: A0A060JG56
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

529884:RHOLA RS01545
gene id: 529884:RHOLA_RS01545
uniprot id: A0A060JF24
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06605
gene id: 529884:RHOLA_RS06605
uniprot id: A0A060JHE1
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06195
gene id: 529884:RHOLA_RS06195
uniprot id: A0A060JPD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

529884:RHOLA RS01460
gene id: 529884:RHOLA_RS01460
uniprot id: A0A060JB93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS04210
gene id: 529884:RHOLA_RS04210
uniprot id: A0A060JM74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

529884:RHOLA RS00620
gene id: 529884:RHOLA_RS00620
uniprot id: A0A060JKZ5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

529884:RHOLA RS07455
gene id: 529884:RHOLA_RS07455
uniprot id: A0A060JDC8
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

529884:RHOLA RS02100
gene id: 529884:RHOLA_RS02100
uniprot id: A0A060JFC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

529884:RHOLA RS00840
gene id: 529884:RHOLA_RS00840
uniprot id: A0A060JAU1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS00365
gene id: 529884:RHOLA_RS00365
uniprot id: A0A060JJV5
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

529884:RHOLA RS06050
gene id: 529884:RHOLA_RS06050
uniprot id: A0A060JH00
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

529884:RHOLA RS02470
gene id: 529884:RHOLA_RS02470
uniprot id: A0A060JBR1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

529884:RHOLA RS00395
gene id: 529884:RHOLA_RS00395
uniprot id: A0A060JKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS03595
gene id: 529884:RHOLA_RS03595
uniprot id: A0A060JLR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

529884:RHOLA RS05955
gene id: 529884:RHOLA_RS05955
uniprot id: A0A060JDP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

529884:RHOLA RS03730
gene id: 529884:RHOLA_RS03730
uniprot id: A0A060JFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

529884:RHOLA RS06110
gene id: 529884:RHOLA_RS06110
uniprot id: A0A060JHJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

529884:RHOLA RS04060
gene id: 529884:RHOLA_RS04060
uniprot id: A0A060JM31
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS02230
gene id: 529884:RHOLA_RS02230
uniprot id: A0A060JKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

529884:RHOLA RS06115
gene id: 529884:RHOLA_RS06115
uniprot id: A0A060JN55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

529884:RHOLA RS01190
gene id: 529884:RHOLA_RS01190
uniprot id: A0A060JLD0
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06245
gene id: 529884:RHOLA_RS06245
uniprot id: A0A060JN81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

529884:RHOLA RS06160
gene id: 529884:RHOLA_RS06160
uniprot id: A0A060JHK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

529884:RHOLA RS02795
gene id: 529884:RHOLA_RS02795
uniprot id: A0A060JFM8
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

529884:RHOLA RS00975
gene id: 529884:RHOLA_RS00975
uniprot id: A0A060JE33
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

529884:RHOLA RS03130
gene id: 529884:RHOLA_RS03130
uniprot id: A0A060JC37
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

529884:RHOLA RS03740
gene id: 529884:RHOLA_RS03740
uniprot id: A0A060JG75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

529884:RHOLA RS05520
gene id: 529884:RHOLA_RS05520
uniprot id: A0A060JGP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

529884:RHOLA RS05295
gene id: 529884:RHOLA_RS05295
uniprot id: A0A060JDA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

529884:RHOLA RS05825
gene id: 529884:RHOLA_RS05825
uniprot id: A0A060JDL7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05900
gene id: 529884:RHOLA_RS05900
uniprot id: A0A060JGW7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

529884:RHOLA RS06630
gene id: 529884:RHOLA_RS06630
uniprot id: A0A060JHE8
names: Similarity
messages: Belongs to the FBPase class 2 family.

529884:RHOLA RS05390
gene id: 529884:RHOLA_RS05390
uniprot id: A0A060JMR6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05920
gene id: 529884:RHOLA_RS05920
uniprot id: A0A060JP68
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

529884:RHOLA RS01145
gene id: 529884:RHOLA_RS01145
uniprot id: A0A060JB18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

529884:RHOLA RS00430
gene id: 529884:RHOLA_RS00430
uniprot id: A0A060JAK6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

529884:RHOLA RS04685
gene id: 529884:RHOLA_RS04685
uniprot id: A0A060JGT9
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS05050
gene id: 529884:RHOLA_RS05050
uniprot id: A0A060JGG2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS04530
gene id: 529884:RHOLA_RS04530
uniprot id: A0A060JGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

529884:RHOLA RS00135
gene id: 529884:RHOLA_RS00135
uniprot id: A0A060JJQ8
names: Similarity
messages: Belongs to the arginase family.

529884:RHOLA RS01675
gene id: 529884:RHOLA_RS01675
uniprot id: A0A060JLR3
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06830
gene id: 529884:RHOLA_RS06830
uniprot id: A0A060JHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS05550
gene id: 529884:RHOLA_RS05550
uniprot id: A0A060JDG0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

529884:RHOLA RS03650
gene id: 529884:RHOLA_RS03650
uniprot id: A0A060JMT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

529884:RHOLA RS03105
gene id: 529884:RHOLA_RS03105
uniprot id: A0A060JC32
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

529884:RHOLA RS06130
gene id: 529884:RHOLA_RS06130
uniprot id: A0A060JDT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

529884:RHOLA RS06085
gene id: 529884:RHOLA_RS06085
uniprot id: A0A060JHI7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

529884:RHOLA RS01240
gene id: 529884:RHOLA_RS01240
uniprot id: A0A060JLE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

529884:RHOLA RS00295
gene id: 529884:RHOLA_RS00295
uniprot id: A0A060JDP7
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06550
gene id: 529884:RHOLA_RS06550
uniprot id: A0A060JE37
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Belongs to the acyl-CoA oxidase family.

529884:RHOLA RS06460
gene id: 529884:RHOLA_RS06460
uniprot id: A0A060JND6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

529884:RHOLA RS06215
gene id: 529884:RHOLA_RS06215
uniprot id: A0A060JN76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

529884:RHOLA RS03930
gene id: 529884:RHOLA_RS03930
uniprot id: A0A060JMZ9
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

529884:RHOLA RS04075
gene id: 529884:RHOLA_RS04075
uniprot id: A0A060JCP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

529884:RHOLA RS04765
gene id: 529884:RHOLA_RS04765
uniprot id: A0A060JMF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

529884:RHOLA RS02550
gene id: 529884:RHOLA_RS02550
uniprot id: A0A060JEZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

529884:RHOLA RS00740
gene id: 529884:RHOLA_RS00740
uniprot id: A0A060JL22
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

529884:RHOLA RS06100
gene id: 529884:RHOLA_RS06100
uniprot id: A0A060JH15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

529884:RHOLA RS04880
gene id: 529884:RHOLA_RS04880
uniprot id: A0A060JGD0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

529884:RHOLA RS00210
gene id: 529884:RHOLA_RS00210
uniprot id: A0A060JJS3
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03240
gene id: 529884:RHOLA_RS03240
uniprot id: A0A060JC56
names: Similarity
messages: Belongs to the CdaR family.

529884:RHOLA RS05090
gene id: 529884:RHOLA_RS05090
uniprot id: A0A060JH01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

529884:RHOLA RS03920
gene id: 529884:RHOLA_RS03920
uniprot id: A0A060JGB9
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

529884:RHOLA RS03705
gene id: 529884:RHOLA_RS03705
uniprot id: A0A060JFN9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06690
gene id: 529884:RHOLA_RS06690
uniprot id: A0A060JI38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

529884:RHOLA RS02110
gene id: 529884:RHOLA_RS02110
uniprot id: A0A060JLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

529884:RHOLA RS00185
gene id: 529884:RHOLA_RS00185
uniprot id: A0A060JJR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

529884:RHOLA RS00710
gene id: 529884:RHOLA_RS00710
uniprot id: A0A060JK28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS03295
gene id: 529884:RHOLA_RS03295
uniprot id: A0A060JC64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

529884:RHOLA RS00415
gene id: 529884:RHOLA_RS00415
uniprot id: A0A060JJW5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

529884:RHOLA RS04910
gene id: 529884:RHOLA_RS04910
uniprot id: A0A060JGX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

529884:RHOLA RS01940
gene id: 529884:RHOLA_RS01940
uniprot id: A0A060JF96
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

529884:RHOLA RS04510
gene id: 529884:RHOLA_RS04510
uniprot id: A0A060JMB4
names: Similarity
messages: Belongs to the FPG family.

529884:RHOLA RS03990
gene id: 529884:RHOLA_RS03990
uniprot id: A0A060JFV5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

529884:RHOLA RS06990
gene id: 529884:RHOLA_RS06990
uniprot id: A0A060JI82
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

529884:RHOLA RS05660
gene id: 529884:RHOLA_RS05660
uniprot id: A0A060JMW9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

529884:RHOLA RS03335
gene id: 529884:RHOLA_RS03335
uniprot id: A0A060JMK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

529884:RHOLA RS00790
gene id: 529884:RHOLA_RS00790
uniprot id: A0A060JAT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

529884:RHOLA RS03355
gene id: 529884:RHOLA_RS03355
uniprot id: A0A060JLL1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

529884:RHOLA RS02300
gene id: 529884:RHOLA_RS02300
uniprot id: A0A060JFF5
names: Similarity
messages: Belongs to the peptidase M16 family.

529884:RHOLA RS02590
gene id: 529884:RHOLA_RS02590
uniprot id: A0A060JL62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

529884:RHOLA RS06715
gene id: 529884:RHOLA_RS06715
uniprot id: A0A060JI42
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00855
gene id: 529884:RHOLA_RS00855
uniprot id: A0A060JL45
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

529884:RHOLA RS03770
gene id: 529884:RHOLA_RS03770
uniprot id: A0A060JLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

529884:RHOLA RS04470
gene id: 529884:RHOLA_RS04470
uniprot id: A0A060JG71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00240
gene id: 529884:RHOLA_RS00240
uniprot id: A0A060JKR7
names: Similarity
messages: Belongs to the peptidase M13 family.

529884:RHOLA RS06675
gene id: 529884:RHOLA_RS06675
uniprot id: A0A060JPR5
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS04905
gene id: 529884:RHOLA_RS04905
uniprot id: A0A060JD35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

529884:RHOLA RS03685
gene id: 529884:RHOLA_RS03685
uniprot id: A0A060JCF5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS03875
gene id: 529884:RHOLA_RS03875
uniprot id: A0A060JLY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

529884:RHOLA RS05865
gene id: 529884:RHOLA_RS05865
uniprot id: A0A060JN07
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

529884:RHOLA RS05840
gene id: 529884:RHOLA_RS05840
uniprot id: A0A060JGV9
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

529884:RHOLA RS04025
gene id: 529884:RHOLA_RS04025
uniprot id: A0A060JGE8
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

529884:RHOLA RS03775
gene id: 529884:RHOLA_RS03775
uniprot id: A0A060JMW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

529884:RHOLA RS00920
gene id: 529884:RHOLA_RS00920
uniprot id: A0A060JEJ7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

529884:RHOLA RS03015
gene id: 529884:RHOLA_RS03015
uniprot id: A0A060JLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

529884:RHOLA RS03945
gene id: 529884:RHOLA_RS03945
uniprot id: A0A060JGC6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

529884:RHOLA RS06125
gene id: 529884:RHOLA_RS06125
uniprot id: A0A060JH22
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

529884:RHOLA RS06060
gene id: 529884:RHOLA_RS06060
uniprot id: A0A060JHI3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

529884:RHOLA RS00010
gene id: 529884:RHOLA_RS00010
uniprot id: A0A060JDJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

529884:RHOLA RS02475
gene id: 529884:RHOLA_RS02475
uniprot id: A0A060JFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

529884:RHOLA RS02895
gene id: 529884:RHOLA_RS02895
uniprot id: A0A060JF60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

529884:RHOLA RS03350
gene id: 529884:RHOLA_RS03350
uniprot id: A0A060JFY7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

529884:RHOLA RS03840
gene id: 529884:RHOLA_RS03840
uniprot id: A0A060JCJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

529884:RHOLA RS02040
gene id: 529884:RHOLA_RS02040
uniprot id: A0A060JEQ6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

529884:RHOLA RS01700
gene id: 529884:RHOLA_RS01700
uniprot id: A0A060JLR6
names: Similarity
messages: Belongs to the peptidase S13 family.

529884:RHOLA RS03485
gene id: 529884:RHOLA_RS03485
uniprot id: A0A060JMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03670
gene id: 529884:RHOLA_RS03670
uniprot id: A0A060JLT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

529884:RHOLA RS02195
gene id: 529884:RHOLA_RS02195
uniprot id: A0A060JBL6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02335
gene id: 529884:RHOLA_RS02335
uniprot id: A0A060JM19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

529884:RHOLA RS00300
gene id: 529884:RHOLA_RS00300
uniprot id: A0A060JAH8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

529884:RHOLA RS06055
gene id: 529884:RHOLA_RS06055
uniprot id: A0A060JDR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

529884:RHOLA RS04545
gene id: 529884:RHOLA_RS04545
uniprot id: A0A060JG80
names: Similarity
messages: Belongs to the citrate synthase family.

529884:RHOLA RS01745
gene id: 529884:RHOLA_RS01745
uniprot id: A0A060JKS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

529884:RHOLA RS01175
gene id: 529884:RHOLA_RS01175
uniprot id: A0A060JB23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

529884:RHOLA RS02955
gene id: 529884:RHOLA_RS02955
uniprot id: A0A060JFQ7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

529884:RHOLA RS02765
gene id: 529884:RHOLA_RS02765
uniprot id: A0A060JBW4
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

529884:RHOLA RS02200
gene id: 529884:RHOLA_RS02200
uniprot id: A0A060JFD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

529884:RHOLA RS03690
gene id: 529884:RHOLA_RS03690
uniprot id: A0A060JG62
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

529884:RHOLA RS02415
gene id: 529884:RHOLA_RS02415
uniprot id: A0A060JEW8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

529884:RHOLA RS06730
gene id: 529884:RHOLA_RS06730
uniprot id: A0A060JHJ1
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus membrane

529884:RHOLA RS03655
gene id: 529884:RHOLA_RS03655
uniprot id: A0A060JFM6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

529884:RHOLA RS01875
gene id: 529884:RHOLA_RS01875
uniprot id: A0A060JLU4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

529884:RHOLA RS04895
gene id: 529884:RHOLA_RS04895
uniprot id: A0A060JMH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

529884:RHOLA RS02380
gene id: 529884:RHOLA_RS02380
uniprot id: A0A060JL23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS06400
gene id: 529884:RHOLA_RS06400
uniprot id: A0A060JH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS00700
gene id: 529884:RHOLA_RS00700
uniprot id: A0A060JAR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

529884:RHOLA RS06300
gene id: 529884:RHOLA_RS06300
uniprot id: A0A060JH70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

529884:RHOLA RS06015
gene id: 529884:RHOLA_RS06015
uniprot id: A0A060JN35
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

529884:RHOLA RS04485
gene id: 529884:RHOLA_RS04485
uniprot id: A0A060JMB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

529884:RHOLA RS05300
gene id: 529884:RHOLA_RS05300
uniprot id: A0A060JH39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

529884:RHOLA RS07310
gene id: 529884:RHOLA_RS07310
uniprot id: A0A060JEC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

529884:RHOLA RS02390
gene id: 529884:RHOLA_RS02390
uniprot id: A0A060JEW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05995
gene id: 529884:RHOLA_RS05995
uniprot id: A0A060JP84
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS02910
gene id: 529884:RHOLA_RS02910
uniprot id: A0A060JLC6
names: Similarity
messages: Belongs to the NDK family.

529884:RHOLA RS01255
gene id: 529884:RHOLA_RS01255
uniprot id: A0A060JB43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

529884:RHOLA RS04640
gene id: 529884:RHOLA_RS04640
uniprot id: A0A060JMD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

529884:RHOLA RS04710
gene id: 529884:RHOLA_RS04710
uniprot id: A0A060JGU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

529884:RHOLA RS07105
gene id: 529884:RHOLA_RS07105
uniprot id: A0A060JME2
names: Similarity
messages: Belongs to the peptidase S8 family.

529884:RHOLA RS05950
gene id: 529884:RHOLA_RS05950
uniprot id: A0A060JGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

529884:RHOLA RS00760
gene id: 529884:RHOLA_RS00760
uniprot id: A0A060JK39
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

529884:RHOLA RS02025
gene id: 529884:RHOLA_RS02025
uniprot id: A0A060JFA9
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

529884:RHOLA RS02605
gene id: 529884:RHOLA_RS02605
uniprot id: A0A060JBT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

529884:RHOLA RS06105
gene id: 529884:RHOLA_RS06105
uniprot id: A0A060JDS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

529884:RHOLA RS04555
gene id: 529884:RHOLA_RS04555
uniprot id: A0A060JGS0
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

529884:RHOLA RS02915
gene id: 529884:RHOLA_RS02915
uniprot id: A0A060JMB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

529884:RHOLA RS03640
gene id: 529884:RHOLA_RS03640
uniprot id: A0A060JG49
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00350
gene id: 529884:RHOLA_RS00350
uniprot id: A0A060JAJ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

529884:RHOLA RS04295
gene id: 529884:RHOLA_RS04295
uniprot id: A0A060JG47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

529884:RHOLA RS01955
gene id: 529884:RHOLA_RS01955
uniprot id: A0A060JEP5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

529884:RHOLA RS03540
gene id: 529884:RHOLA_RS03540
uniprot id: A0A060JG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

529884:RHOLA RS01725
gene id: 529884:RHOLA_RS01725
uniprot id: A0A060JLS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

529884:RHOLA RS04370
gene id: 529884:RHOLA_RS04370
uniprot id: A0A060JG57
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

529884:RHOLA RS01005
gene id: 529884:RHOLA_RS01005
uniprot id: A0A060JAY8
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03645
gene id: 529884:RHOLA_RS03645
uniprot id: A0A060JLS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

529884:RHOLA RS01160
gene id: 529884:RHOLA_RS01160
uniprot id: A0A060JKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

529884:RHOLA RS03570
gene id: 529884:RHOLA_RS03570
uniprot id: A0A060JLQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

529884:RHOLA RS02495
gene id: 529884:RHOLA_RS02495
uniprot id: A0A060JBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

529884:RHOLA RS06065
gene id: 529884:RHOLA_RS06065
uniprot id: A0A060JN46
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS07015
gene id: 529884:RHOLA_RS07015
uniprot id: A0A060JDZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

529884:RHOLA RS06500
gene id: 529884:RHOLA_RS06500
uniprot id: A0A060JE27
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS04465
gene id: 529884:RHOLA_RS04465
uniprot id: A0A060JNE3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

529884:RHOLA RS02250
gene id: 529884:RHOLA_RS02250
uniprot id: A0A060JFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

529884:RHOLA RS01430
gene id: 529884:RHOLA_RS01430
uniprot id: A0A060JEC6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

529884:RHOLA RS00785
gene id: 529884:RHOLA_RS00785
uniprot id: A0A060JDZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

529884:RHOLA RS05650
gene id: 529884:RHOLA_RS05650
uniprot id: A0A060JDI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

529884:RHOLA RS02385
gene id: 529884:RHOLA_RS02385
uniprot id: A0A060JM27
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS03215
gene id: 529884:RHOLA_RS03215
uniprot id: A0A060JC52
names: Similarity
messages: Belongs to the thymidine kinase family.

529884:RHOLA RS03830
gene id: 529884:RHOLA_RS03830
uniprot id: A0A060JMX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

529884:RHOLA RS04505
gene id: 529884:RHOLA_RS04505
uniprot id: A0A060JGR4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

529884:RHOLA RS03125
gene id: 529884:RHOLA_RS03125
uniprot id: A0A060JFB1
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

529884:RHOLA RS04270
gene id: 529884:RHOLA_RS04270
uniprot id: A0A060JG43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

529884:RHOLA RS06135
gene id: 529884:RHOLA_RS06135
uniprot id: A0A060JHK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

529884:RHOLA RS01170
gene id: 529884:RHOLA_RS01170
uniprot id: A0A060JE66
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

529884:RHOLA RS04930
gene id: 529884:RHOLA_RS04930
uniprot id: A0A060JGX5
names: Similarity
messages: Belongs to the peptidase A24 family.

529884:RHOLA RS02450
gene id: 529884:RHOLA_RS02450
uniprot id: A0A060JFI0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

529884:RHOLA RS05670
gene id: 529884:RHOLA_RS05670
uniprot id: A0A060JGS3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

529884:RHOLA RS03170
gene id: 529884:RHOLA_RS03170
uniprot id: A0A060JLH7
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06900
gene id: 529884:RHOLA_RS06900
uniprot id: A0A060JHL8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS07065
gene id: 529884:RHOLA_RS07065
uniprot id: A0A060JCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

529884:RHOLA RS02010
gene id: 529884:RHOLA_RS02010
uniprot id: A0A060JEQ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

529884:RHOLA RS00080
gene id: 529884:RHOLA_RS00080
uniprot id: A0A060JE51
names: Similarity
messages: Belongs to the ABC transporter superfamily.

529884:RHOLA RS00860
gene id: 529884:RHOLA_RS00860
uniprot id: A0A060JE12
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

529884:RHOLA RS03680
gene id: 529884:RHOLA_RS03680
uniprot id: A0A060JFN2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

529884:RHOLA RS05545
gene id: 529884:RHOLA_RS05545
uniprot id: A0A060JGP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

529884:RHOLA RS00725
gene id: 529884:RHOLA_RS00725
uniprot id: A0A060JAR7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

529884:RHOLA RS06905
gene id: 529884:RHOLA_RS06905
uniprot id: A0A060JEB2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

529884:RHOLA RS06965
gene id: 529884:RHOLA_RS06965
uniprot id: A0A060JNP7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

529884:RHOLA RS01900
gene id: 529884:RHOLA_RS01900
uniprot id: A0A060JLU8
names: Similarity
messages: Belongs to the peptidase M24B family.

529884:RHOLA RS05915
gene id: 529884:RHOLA_RS05915
uniprot id: A0A060JN15
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

529884:RHOLA RS00265
gene id: 529884:RHOLA_RS00265
uniprot id: A0A060JKS2
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS02190
gene id: 529884:RHOLA_RS02190
uniprot id: A0A060JET2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

529884:RHOLA RS03320
gene id: 529884:RHOLA_RS03320
uniprot id: A0A060JC69
names: Similarity
messages: Belongs to the glutamine synthetase family.

529884:RHOLA RS01645
gene id: 529884:RHOLA_RS01645
uniprot id: A0A060JKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

529884:RHOLA RS01360
gene id: 529884:RHOLA_RS01360
uniprot id: A0A060JB68
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02370
gene id: 529884:RHOLA_RS02370
uniprot id: A0A060JBP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

529884:RHOLA RS03340
gene id: 529884:RHOLA_RS03340
uniprot id: A0A060JFF3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

529884:RHOLA RS00835
gene id: 529884:RHOLA_RS00835
uniprot id: A0A060JE08
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

529884:RHOLA RS05385
gene id: 529884:RHOLA_RS05385
uniprot id: A0A060JH52
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

529884:RHOLA RS06950
gene id: 529884:RHOLA_RS06950
uniprot id: A0A060JHM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

529884:RHOLA RS02050
gene id: 529884:RHOLA_RS02050
uniprot id: A0A060JFB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

529884:RHOLA RS02560
gene id: 529884:RHOLA_RS02560
uniprot id: A0A060JFJ4
names: Similarity
messages: Belongs to the UPF0102 family.

529884:RHOLA RS05445
gene id: 529884:RHOLA_RS05445
uniprot id: A0A060JGM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

529884:RHOLA RS06420
gene id: 529884:RHOLA_RS06420
uniprot id: A0A060JH97
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

529884:RHOLA RS05370
gene id: 529884:RHOLA_RS05370
uniprot id: A0A060JNU1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

529884:RHOLA RS05870
gene id: 529884:RHOLA_RS05870
uniprot id: A0A060JP55
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

529884:RHOLA RS02575
gene id: 529884:RHOLA_RS02575
uniprot id: A0A060JEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

529884:RHOLA RS05750
gene id: 529884:RHOLA_RS05750
uniprot id: A0A060JDK3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

529884:RHOLA RS03050
gene id: 529884:RHOLA_RS03050
uniprot id: A0A060JF94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

529884:RHOLA RS03470
gene id: 529884:RHOLA_RS03470
uniprot id: A0A060JCA5
names: Similarity
messages: Belongs to the SufE family.

529884:RHOLA RS06385
gene id: 529884:RHOLA_RS06385
uniprot id: A0A060JHS3
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

529884:RHOLA RS03860
gene id: 529884:RHOLA_RS03860
uniprot id: A0A060JFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

529884:RHOLA RS02325
gene id: 529884:RHOLA_RS02325
uniprot id: A0A060JFF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

529884:RHOLA RS00815
gene id: 529884:RHOLA_RS00815
uniprot id: A0A060JAT6
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

529884:RHOLA RS01560
gene id: 529884:RHOLA_RS01560
uniprot id: A0A060JEG5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

529884:RHOLA RS05835
gene id: 529884:RHOLA_RS05835
uniprot id: A0A060JN02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06090
gene id: 529884:RHOLA_RS06090
uniprot id: A0A060JN50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

529884:RHOLA RS01500
gene id: 529884:RHOLA_RS01500
uniprot id: A0A060JLK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05980
gene id: 529884:RHOLA_RS05980
uniprot id: A0A060JDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

529884:RHOLA RS06000
gene id: 529884:RHOLA_RS06000
uniprot id: A0A060JGY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

529884:RHOLA RS06890
gene id: 529884:RHOLA_RS06890
uniprot id: A0A060JNN3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

529884:RHOLA RS04900
gene id: 529884:RHOLA_RS04900
uniprot id: A0A060JGD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

529884:RHOLA RS02260
gene id: 529884:RHOLA_RS02260
uniprot id: A0A060JM07
names: Similarity
messages: Belongs to the PstS family.

529884:RHOLA RS06040
gene id: 529884:RHOLA_RS06040
uniprot id: A0A060JN40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

529884:RHOLA RS02420
gene id: 529884:RHOLA_RS02420
uniprot id: A0A060JBQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

529884:RHOLA RS02665
gene id: 529884:RHOLA_RS02665
uniprot id: A0A060JL77
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

529884:RHOLA RS03165
gene id: 529884:RHOLA_RS03165
uniprot id: A0A060JFU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

529884:RHOLA RS02850
gene id: 529884:RHOLA_RS02850
uniprot id: A0A060JLB5
names: Similarity
messages: Belongs to the FPG family.

529884:RHOLA RS03635
gene id: 529884:RHOLA_RS03635
uniprot id: A0A060JCE2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS04140
gene id: 529884:RHOLA_RS04140
uniprot id: A0A060JN63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS04245
gene id: 529884:RHOLA_RS04245
uniprot id: A0A060JG40
names: Similarity
messages: Belongs to the YggT family.

529884:RHOLA RS03040
gene id: 529884:RHOLA_RS03040
uniprot id: A0A060JLF3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

529884:RHOLA RS04865
gene id: 529884:RHOLA_RS04865
uniprot id: A0A060JGW5
names: Similarity
messages: Belongs to the AHA1 family.

529884:RHOLA RS00905
gene id: 529884:RHOLA_RS00905
uniprot id: A0A060JL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS03230
gene id: 529884:RHOLA_RS03230
uniprot id: A0A060JMI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

529884:RHOLA RS02005
gene id: 529884:RHOLA_RS02005
uniprot id: A0A060JLW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

529884:RHOLA RS06335
gene id: 529884:RHOLA_RS06335
uniprot id: A0A060JHQ9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

529884:RHOLA RS03000
gene id: 529884:RHOLA_RS03000
uniprot id: A0A060JF83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS04520
gene id: 529884:RHOLA_RS04520
uniprot id: A0A060JG77
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

529884:RHOLA RS02295
gene id: 529884:RHOLA_RS02295
uniprot id: A0A060JBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

529884:RHOLA RS05350
gene id: 529884:RHOLA_RS05350
uniprot id: A0A060JGK7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

529884:RHOLA RS04420
gene id: 529884:RHOLA_RS04420
uniprot id: A0A060JG65
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

529884:RHOLA RS02865
gene id: 529884:RHOLA_RS02865
uniprot id: A0A060JMA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

529884:RHOLA RS00780
gene id: 529884:RHOLA_RS00780
uniprot id: A0A060JL27
names: Similarity
messages: Belongs to the peptidase C40 family.

529884:RHOLA RS04605
gene id: 529884:RHOLA_RS04605
uniprot id: A0A060JCZ6
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03325
gene id: 529884:RHOLA_RS03325
uniprot id: A0A060JFY1
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03660
gene id: 529884:RHOLA_RS03660
uniprot id: A0A060JCE9
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

529884:RHOLA RS03795
gene id: 529884:RHOLA_RS03795
uniprot id: A0A060JLW6
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

529884:RHOLA RS07030
gene id: 529884:RHOLA_RS07030
uniprot id: A0A060JAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

529884:RHOLA RS04255
gene id: 529884:RHOLA_RS04255
uniprot id: A0A060JGM8
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

529884:RHOLA RS01365
gene id: 529884:RHOLA_RS01365
uniprot id: A0A060JEV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

529884:RHOLA RS04550
gene id: 529884:RHOLA_RS04550
uniprot id: A0A060JCZ1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

529884:RHOLA RS02115
gene id: 529884:RHOLA_RS02115
uniprot id: A0A060JES0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

529884:RHOLA RS04350
gene id: 529884:RHOLA_RS04350
uniprot id: A0A060JCW6
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

529884:RHOLA RS03895
gene id: 529884:RHOLA_RS03895
uniprot id: A0A060JGB0
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05755
gene id: 529884:RHOLA_RS05755
uniprot id: A0A060JHC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS01915
gene id: 529884:RHOLA_RS01915
uniprot id: A0A060JF93
names: Similarity
messages: Belongs to the DEAD box helicase family.

529884:RHOLA RS04175
gene id: 529884:RHOLA_RS04175
uniprot id: A0A060JCU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

529884:RHOLA RS04315
gene id: 529884:RHOLA_RS04315
uniprot id: A0A060JNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

529884:RHOLA RS06850
gene id: 529884:RHOLA_RS06850
uniprot id: A0A060JPV5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

529884:RHOLA RS02570
gene id: 529884:RHOLA_RS02570
uniprot id: A0A060JM56
names: Similarity
messages: Belongs to the DprA/Smf family.

529884:RHOLA RS02160
gene id: 529884:RHOLA_RS02160
uniprot id: A0A060JLZ0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

529884:RHOLA RS00100
gene id: 529884:RHOLA_RS00100
uniprot id: A0A060JAE2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

529884:RHOLA RS06915
gene id: 529884:RHOLA_RS06915
uniprot id: A0A060JNN8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

529884:RHOLA RS02940
gene id: 529884:RHOLA_RS02940
uniprot id: A0A060JMC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05185
gene id: 529884:RHOLA_RS05185
uniprot id: A0A060JNQ8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

529884:RHOLA RS06250
gene id: 529884:RHOLA_RS06250
uniprot id: A0A060JPE1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

529884:RHOLA RS06545
gene id: 529884:RHOLA_RS06545
uniprot id: A0A060JHC8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

529884:RHOLA RS06720
gene id: 529884:RHOLA_RS06720
uniprot id: A0A060JNK8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

529884:RHOLA RS04870
gene id: 529884:RHOLA_RS04870
uniprot id: A0A060JMG9
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

529884:RHOLA RS00170
gene id: 529884:RHOLA_RS00170
uniprot id: A0A060JDM4
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06190
gene id: 529884:RHOLA_RS06190
uniprot id: A0A060JN72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

529884:RHOLA RS01025
gene id: 529884:RHOLA_RS01025
uniprot id: A0A060JE44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

529884:RHOLA RS02995
gene id: 529884:RHOLA_RS02995
uniprot id: A0A060JMD3
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

529884:RHOLA RS05340
gene id: 529884:RHOLA_RS05340
uniprot id: A0A060JMQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS02880
gene id: 529884:RHOLA_RS02880
uniprot id: A0A060JFP3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

529884:RHOLA RS05600
gene id: 529884:RHOLA_RS05600
uniprot id: A0A060JDH1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

529884:RHOLA RS02810
gene id: 529884:RHOLA_RS02810
uniprot id: A0A060JF41
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

529884:RHOLA RS00390
gene id: 529884:RHOLA_RS00390
uniprot id: A0A060JJW0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

529884:RHOLA RS00675
gene id: 529884:RHOLA_RS00675
uniprot id: A0A060JAQ7
names: Similarity
messages: Belongs to the GARS family.

529884:RHOLA RS04120
gene id: 529884:RHOLA_RS04120
uniprot id: A0A060JFY9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

529884:RHOLA RS00495
gene id: 529884:RHOLA_RS00495
uniprot id: A0A060JKW5
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS01800
gene id: 529884:RHOLA_RS01800
uniprot id: A0A060JLT2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06945
gene id: 529884:RHOLA_RS06945
uniprot id: A0A060JPW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

529884:RHOLA RS04080
gene id: 529884:RHOLA_RS04080
uniprot id: A0A060JGG3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

529884:RHOLA RS03885
gene id: 529884:RHOLA_RS03885
uniprot id: A0A060JFT3
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

529884:RHOLA RS04675
gene id: 529884:RHOLA_RS04675
uniprot id: A0A060JD04
names: Similarity
messages: Belongs to the GSP E family.

529884:RHOLA RS02465
gene id: 529884:RHOLA_RS02465
uniprot id: A0A060JEX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

529884:RHOLA RS02845
gene id: 529884:RHOLA_RS02845
uniprot id: A0A060JFN8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

529884:RHOLA RS06800
gene id: 529884:RHOLA_RS06800
uniprot id: A0A060JPU7
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS05605
gene id: 529884:RHOLA_RS05605
uniprot id: A0A060JH93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05905
gene id: 529884:RHOLA_RS05905
uniprot id: A0A060JDN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03265
gene id: 529884:RHOLA_RS03265
uniprot id: A0A060JFD6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

529884:RHOLA RS00110
gene id: 529884:RHOLA_RS00110
uniprot id: A0A060JJQ5
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS02235
gene id: 529884:RHOLA_RS02235
uniprot id: A0A060JM02
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

529884:RHOLA RS05990
gene id: 529884:RHOLA_RS05990
uniprot id: A0A060JN30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

529884:RHOLA RS04100
gene id: 529884:RHOLA_RS04100
uniprot id: A0A060JCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

529884:RHOLA RS04885
gene id: 529884:RHOLA_RS04885
uniprot id: A0A060JD32
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

529884:RHOLA RS00315
gene id: 529884:RHOLA_RS00315
uniprot id: A0A060JKT1
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS04415
gene id: 529884:RHOLA_RS04415
uniprot id: A0A060JND4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

529884:RHOLA RS06145
gene id: 529884:RHOLA_RS06145
uniprot id: A0A060JPC0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

529884:RHOLA RS04290
gene id: 529884:RHOLA_RS04290
uniprot id: A0A060JNB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03870
gene id: 529884:RHOLA_RS03870
uniprot id: A0A060JGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

529884:RHOLA RS00580
gene id: 529884:RHOLA_RS00580
uniprot id: A0A060JAN8
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

529884:RHOLA RS05830
gene id: 529884:RHOLA_RS05830
uniprot id: A0A060JHD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

529884:RHOLA RS01495
gene id: 529884:RHOLA_RS01495
uniprot id: A0A060JKL0
names: Similarity
messages: Belongs to the CsoR family.

529884:RHOLA RS03695
gene id: 529884:RHOLA_RS03695
uniprot id: A0A060JLT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

529884:RHOLA RS05015
gene id: 529884:RHOLA_RS05015
uniprot id: A0A060JMJ7
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

529884:RHOLA RS04180
gene id: 529884:RHOLA_RS04180
uniprot id: A0A060JGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

529884:RHOLA RS05380
gene id: 529884:RHOLA_RS05380
uniprot id: A0A060JDC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

529884:RHOLA RS06080
gene id: 529884:RHOLA_RS06080
uniprot id: A0A060JDS1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

529884:RHOLA RS02490
gene id: 529884:RHOLA_RS02490
uniprot id: A0A060JEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

529884:RHOLA RS02210
gene id: 529884:RHOLA_RS02210
uniprot id: A0A060JLZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS00150
gene id: 529884:RHOLA_RS00150
uniprot id: A0A060JAF2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06395
gene id: 529884:RHOLA_RS06395
uniprot id: A0A060JPH1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

529884:RHOLA RS05760
gene id: 529884:RHOLA_RS05760
uniprot id: A0A060JMY9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

529884:RHOLA RS06510
gene id: 529884:RHOLA_RS06510
uniprot id: A0A060JNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS03815
gene id: 529884:RHOLA_RS03815
uniprot id: A0A060JCI7
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

529884:RHOLA RS02890
gene id: 529884:RHOLA_RS02890
uniprot id: A0A060JMB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

529884:RHOLA RS06820
gene id: 529884:RHOLA_RS06820
uniprot id: A0A060JNM3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

529884:RHOLA RS05740
gene id: 529884:RHOLA_RS05740
uniprot id: A0A060JP26
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

529884:RHOLA RS00980
gene id: 529884:RHOLA_RS00980
uniprot id: A0A060JAY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS03835
gene id: 529884:RHOLA_RS03835
uniprot id: A0A060JFS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

529884:RHOLA RS05440
gene id: 529884:RHOLA_RS05440
uniprot id: A0A060JNV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

529884:RHOLA RS00800
gene id: 529884:RHOLA_RS00800
uniprot id: A0A060JK44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

529884:RHOLA RS07150
gene id: 529884:RHOLA_RS07150
uniprot id: A0A060JPG6
names: Similarity
messages: Belongs to the peptidase S8 family.

529884:RHOLA RS04990
gene id: 529884:RHOLA_RS04990
uniprot id: A0A060JMJ2
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

529884:RHOLA RS05075
gene id: 529884:RHOLA_RS05075
uniprot id: A0A060JNN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

529884:RHOLA RS02830
gene id: 529884:RHOLA_RS02830
uniprot id: A0A060JM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

529884:RHOLA RS03575
gene id: 529884:RHOLA_RS03575
uniprot id: A0A060JMR4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

529884:RHOLA RS02095
gene id: 529884:RHOLA_RS02095
uniprot id: A0A060JBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

529884:RHOLA RS03900
gene id: 529884:RHOLA_RS03900
uniprot id: A0A060JLZ1
names: Similarity
messages: Belongs to the GPI family.

529884:RHOLA RS02430
gene id: 529884:RHOLA_RS02430
uniprot id: A0A060JL30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

529884:RHOLA RS03085
gene id: 529884:RHOLA_RS03085
uniprot id: A0A060JFT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

529884:RHOLA RS04945
gene id: 529884:RHOLA_RS04945
uniprot id: A0A060JGE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00850
gene id: 529884:RHOLA_RS00850
uniprot id: A0A060JK53
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

529884:RHOLA RS01055
gene id: 529884:RHOLA_RS01055
uniprot id: A0A060JAZ9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

529884:RHOLA RS02740
gene id: 529884:RHOLA_RS02740
uniprot id: A0A060JBW1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

529884:RHOLA RS02215
gene id: 529884:RHOLA_RS02215
uniprot id: A0A060JET6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

529884:RHOLA RS06205
gene id: 529884:RHOLA_RS06205
uniprot id: A0A060JDV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

529884:RHOLA RS06860
gene id: 529884:RHOLA_RS06860
uniprot id: A0A060JEA5
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

529884:RHOLA RS06640
gene id: 529884:RHOLA_RS06640
uniprot id: A0A060JI02
names: Similarity
messages: Belongs to the hyi family.

529884:RHOLA RS01070
gene id: 529884:RHOLA_RS01070
uniprot id: A0A060JLA6
names: Similarity
messages: Belongs to the UPF0234 family.

529884:RHOLA RS06020
gene id: 529884:RHOLA_RS06020
uniprot id: A0A060JP89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

529884:RHOLA RS04145
gene id: 529884:RHOLA_RS04145
uniprot id: A0A060JG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS04330
gene id: 529884:RHOLA_RS04330
uniprot id: A0A060JGN8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

529884:RHOLA RS02720
gene id: 529884:RHOLA_RS02720
uniprot id: A0A060JL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

529884:RHOLA RS05880
gene id: 529884:RHOLA_RS05880
uniprot id: A0A060JDM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

529884:RHOLA RS05375
gene id: 529884:RHOLA_RS05375
uniprot id: A0A060JGL1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05665
gene id: 529884:RHOLA_RS05665
uniprot id: A0A060JP09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

529884:RHOLA RS03610
gene id: 529884:RHOLA_RS03610
uniprot id: A0A060JCD6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

529884:RHOLA RS00475
gene id: 529884:RHOLA_RS00475
uniprot id: A0A060JDT2
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

529884:RHOLA RS03555
gene id: 529884:RHOLA_RS03555
uniprot id: A0A060JFJ7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

529884:RHOLA RS04495
gene id: 529884:RHOLA_RS04495
uniprot id: A0A060JG74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

529884:RHOLA RS05085
gene id: 529884:RHOLA_RS05085
uniprot id: A0A060JD68
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS02120
gene id: 529884:RHOLA_RS02120
uniprot id: A0A060JBK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

529884:RHOLA RS02060
gene id: 529884:RHOLA_RS02060
uniprot id: A0A060JLX4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

529884:RHOLA RS02000
gene id: 529884:RHOLA_RS02000
uniprot id: A0A060JKV9
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

529884:RHOLA RS05890
gene id: 529884:RHOLA_RS05890
uniprot id: A0A060JN11
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

529884:RHOLA RS02925
gene id: 529884:RHOLA_RS02925
uniprot id: A0A060JBZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

529884:RHOLA RS03405
gene id: 529884:RHOLA_RS03405
uniprot id: A0A060JLL8
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

529884:RHOLA RS02700
gene id: 529884:RHOLA_RS02700
uniprot id: A0A060JF22
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

529884:RHOLA RS06035
gene id: 529884:RHOLA_RS06035
uniprot id: A0A060JHH7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

529884:RHOLA RS05690
gene id: 529884:RHOLA_RS05690
uniprot id: A0A060JP16
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

529884:RHOLA RS04225
gene id: 529884:RHOLA_RS04225
uniprot id: A0A060JCV1
names: Subcellular Location Annotation
messages: Cytoplasm

529884:RHOLA RS02655
gene id: 529884:RHOLA_RS02655
uniprot id: A0A060JBU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

529884:RHOLA RS06925
gene id: 529884:RHOLA_RS06925
uniprot id: A0A060JHM0
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03260
gene id: 529884:RHOLA_RS03260
uniprot id: A0A060JMI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

529884:RHOLA RS04010
gene id: 529884:RHOLA_RS04010
uniprot id: A0A060JN13
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

529884:RHOLA RS01825
gene id: 529884:RHOLA_RS01825
uniprot id: A0A060JLT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

529884:RHOLA RS02695
gene id: 529884:RHOLA_RS02695
uniprot id: A0A060JM75
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

529884:RHOLA RS03565
gene id: 529884:RHOLA_RS03565
uniprot id: A0A060JG28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

529884:RHOLA RS06095
gene id: 529884:RHOLA_RS06095
uniprot id: A0A060JPA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

529884:RHOLA RS06785
gene id: 529884:RHOLA_RS06785
uniprot id: A0A060JE95
names: Similarity
messages: Belongs to the cytochrome P450 family.

529884:RHOLA RS02330
gene id: 529884:RHOLA_RS02330
uniprot id: A0A060JL14
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06165
gene id: 529884:RHOLA_RS06165
uniprot id: A0A060JN67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

529884:RHOLA RS05010
gene id: 529884:RHOLA_RS05010
uniprot id: A0A060JGY6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

529884:RHOLA RS02690
gene id: 529884:RHOLA_RS02690
uniprot id: A0A060JL83
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

529884:RHOLA RS05790
gene id: 529884:RHOLA_RS05790
uniprot id: A0A060JP39
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS01665
gene id: 529884:RHOLA_RS01665
uniprot id: A0A060JF55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system.

529884:RHOLA RS04970
gene id: 529884:RHOLA_RS04970
uniprot id: A0A060JGE7
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

529884:RHOLA RS02545
gene id: 529884:RHOLA_RS02545
uniprot id: A0A060JM52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

529884:RHOLA RS03285
gene id: 529884:RHOLA_RS03285
uniprot id: A0A060JMJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

529884:RHOLA RS06815
gene id: 529884:RHOLA_RS06815
uniprot id: A0A060JI60
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

529884:RHOLA RS06120
gene id: 529884:RHOLA_RS06120
uniprot id: A0A060JPB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

529884:RHOLA RS03925
gene id: 529884:RHOLA_RS03925
uniprot id: A0A060JLZ8
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS04135
gene id: 529884:RHOLA_RS04135
uniprot id: A0A060JM64
names: Similarity
messages: Belongs to the Nudix hydrolase family.

529884:RHOLA RS02480
gene id: 529884:RHOLA_RS02480
uniprot id: A0A060JL40
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

529884:RHOLA RS06955
gene id: 529884:RHOLA_RS06955
uniprot id: A0A060JEB8
names: Similarity
messages: Belongs to the ParB family.

529884:RHOLA RS05535
gene id: 529884:RHOLA_RS05535
uniprot id: A0A060JMU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529884:RHOLA RS06795
gene id: 529884:RHOLA_RS06795
uniprot id: A0A060JNL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529884:RHOLA RS05170
gene id: 529884:RHOLA_RS05170
uniprot id: A0A060JD84
names: Subcellular Location Annotation
messages: Cytoplasm

529884:RHOLA RS03715
gene id: 529884:RHOLA_RS03715
uniprot id: A0A060JG70
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

529884:RHOLA RS02485
gene id: 529884:RHOLA_RS02485
uniprot id: A0A060JM44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

529884:RHOLA RS03100
gene id: 529884:RHOLA_RS03100
uniprot id: A0A060JFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS01850
gene id: 529884:RHOLA_RS01850
uniprot id: A0A060JLU1
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
messages: In the C-terminal section; belongs to the IspF family.
messages: In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS03115
gene id: 529884:RHOLA_RS03115
uniprot id: A0A060JLG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS02870
gene id: 529884:RHOLA_RS02870
uniprot id: A0A060JF53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

529884:RHOLA RS02835
gene id: 529884:RHOLA_RS02835
uniprot id: A0A060JF49
names: Similarity
messages: Belongs to the peptidase M1 family.

529884:RHOLA RS03385
gene id: 529884:RHOLA_RS03385
uniprot id: A0A060JMM1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

529884:RHOLA RS04760
gene id: 529884:RHOLA_RS04760
uniprot id: A0A060JGV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

529884:RHOLA RS02405
gene id: 529884:RHOLA_RS02405
uniprot id: A0A060JL26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

529884:RHOLA RS02965
gene id: 529884:RHOLA_RS02965
uniprot id: A0A060JMC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

529884:RHOLA RS03785
gene id: 529884:RHOLA_RS03785
uniprot id: A0A060JCI0
names: Similarity
messages: Belongs to the glutamate synthase family.

529884:RHOLA RS00095
gene id: 529884:RHOLA_RS00095
uniprot id: A0A060JDL1
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

529884:RHOLA RS03245
gene id: 529884:RHOLA_RS03245
uniprot id: A0A060JFW4
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

529884:RHOLA RS06030
gene id: 529884:RHOLA_RS06030
uniprot id: A0A060JDQ7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

529884:RHOLA RS04630
gene id: 529884:RHOLA_RS04630
uniprot id: A0A060JCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

529884:RHOLA RS06070
gene id: 529884:RHOLA_RS06070
uniprot id: A0A060JPA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

529884:RHOLA RS02535
gene id: 529884:RHOLA_RS02535
uniprot id: A0A060JFJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

529884:RHOLA RS01555
gene id: 529884:RHOLA_RS01555
uniprot id: A0A060JLM7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

529884:RHOLA RS05110
gene id: 529884:RHOLA_RS05110
uniprot id: A0A060JD74
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

529884:RHOLA RS05040
gene id: 529884:RHOLA_RS05040
uniprot id: A0A060JMK3
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS04950
gene id: 529884:RHOLA_RS04950
uniprot id: A0A060JD45
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS05065
gene id: 529884:RHOLA_RS05065
uniprot id: A0A060JGZ7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

529884:RHOLA RS02015
gene id: 529884:RHOLA_RS02015
uniprot id: A0A060JBJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS06200
gene id: 529884:RHOLA_RS06200
uniprot id: A0A060JH44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

529884:RHOLA RS02600
gene id: 529884:RHOLA_RS02600
uniprot id: A0A060JF03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

529884:RHOLA RS01135
gene id: 529884:RHOLA_RS01135
uniprot id: A0A060JLB8
names: Similarity
messages: Belongs to the UPF0336 family.

529884:RHOLA RS04840
gene id: 529884:RHOLA_RS04840
uniprot id: A0A060JGW1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

529884:RHOLA RS04780
gene id: 529884:RHOLA_RS04780
uniprot id: A0A060JD16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

529884:RHOLA RS06435
gene id: 529884:RHOLA_RS06435
uniprot id: A0A060JNC8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

529884:RHOLA RS04300
gene id: 529884:RHOLA_RS04300
uniprot id: A0A060JCW0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06975
gene id: 529884:RHOLA_RS06975
uniprot id: A0A060JHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

529884:RHOLA RS03910
gene id: 529884:RHOLA_RS03910
uniprot id: A0A060JFT7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

529884:RHOLA RS03310
gene id: 529884:RHOLA_RS03310
uniprot id: A0A060JMK0
names: Similarity
messages: Belongs to the glutamine synthetase family.

529884:RHOLA RS06930
gene id: 529884:RHOLA_RS06930
uniprot id: A0A060JEB5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

529884:RHOLA RS04980
gene id: 529884:RHOLA_RS04980
uniprot id: A0A060JGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

529884:RHOLA RS03220
gene id: 529884:RHOLA_RS03220
uniprot id: A0A060JFV8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

529884:RHOLA RS06425
gene id: 529884:RHOLA_RS06425
uniprot id: A0A060JDZ9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02935
gene id: 529884:RHOLA_RS02935
uniprot id: A0A060JLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS01565
gene id: 529884:RHOLA_RS01565
uniprot id: A0A060JBD2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS05570
gene id: 529884:RHOLA_RS05570
uniprot id: A0A060JGQ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

529884:RHOLA RS00305
gene id: 529884:RHOLA_RS00305
uniprot id: A0A060JE80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS05160
gene id: 529884:RHOLA_RS05160
uniprot id: A0A060JNQ3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

529884:RHOLA RS02425
gene id: 529884:RHOLA_RS02425
uniprot id: A0A060JFH5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

529884:RHOLA RS05275
gene id: 529884:RHOLA_RS05275
uniprot id: A0A060JH34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

529884:RHOLA RS01310
gene id: 529884:RHOLA_RS01310
uniprot id: A0A060JB55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

529884:RHOLA RS00235
gene id: 529884:RHOLA_RS00235
uniprot id: A0A060JJS8
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

529884:RHOLA RS04475
gene id: 529884:RHOLA_RS04475
uniprot id: A0A060JCY1
names: Similarity
messages: Belongs to the TlyA family.

529884:RHOLA RS02350
gene id: 529884:RHOLA_RS02350
uniprot id: A0A060JFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

529884:RHOLA RS04250
gene id: 529884:RHOLA_RS04250
uniprot id: A0A060JCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

529884:RHOLA RS00615
gene id: 529884:RHOLA_RS00615
uniprot id: A0A060JK06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

529884:RHOLA RS04965
gene id: 529884:RHOLA_RS04965
uniprot id: A0A060JNL7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

529884:RHOLA RS03850
gene id: 529884:RHOLA_RS03850
uniprot id: A0A060JLX9
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

529884:RHOLA RS00750
gene id: 529884:RHOLA_RS00750
uniprot id: A0A060JAS4
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03825
gene id: 529884:RHOLA_RS03825
uniprot id: A0A060JLX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

529884:RHOLA RS02225
gene id: 529884:RHOLA_RS02225
uniprot id: A0A060JFE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

529884:RHOLA RS01150
gene id: 529884:RHOLA_RS01150
uniprot id: A0A060JEQ8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

529884:RHOLA RS06010
gene id: 529884:RHOLA_RS06010
uniprot id: A0A060JHH4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

529884:RHOLA RS00140
gene id: 529884:RHOLA_RS00140
uniprot id: A0A060JKP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

529884:RHOLA RS05265
gene id: 529884:RHOLA_RS05265
uniprot id: A0A060JGJ4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

529884:RHOLA RS06885
gene id: 529884:RHOLA_RS06885
uniprot id: A0A060JI70
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

529884:RHOLA RS01785
gene id: 529884:RHOLA_RS01785
uniprot id: A0A060JEL5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

529884:RHOLA RS04730
gene id: 529884:RHOLA_RS04730
uniprot id: A0A060JD09
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS00865
gene id: 529884:RHOLA_RS00865
uniprot id: A0A060JAV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

529884:RHOLA RS05930
gene id: 529884:RHOLA_RS05930
uniprot id: A0A060JDN7
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS04450
gene id: 529884:RHOLA_RS04450
uniprot id: A0A060JCX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

529884:RHOLA RS01595
gene id: 529884:RHOLA_RS01595
uniprot id: A0A060JKQ0
names: Similarity
messages: Belongs to the GSP E family.

529884:RHOLA RS00950
gene id: 529884:RHOLA_RS00950
uniprot id: A0A060JL72
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

529884:RHOLA RS05305
gene id: 529884:RHOLA_RS05305
uniprot id: A0A060JMQ0
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS01040
gene id: 529884:RHOLA_RS01040
uniprot id: A0A060JK94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

529884:RHOLA RS04645
gene id: 529884:RHOLA_RS04645
uniprot id: A0A060JNH1
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS05210
gene id: 529884:RHOLA_RS05210
uniprot id: A0A060JNR3
names: Subcellular Location Annotation
messages: Cytoplasm

529884:RHOLA RS04150
gene id: 529884:RHOLA_RS04150
uniprot id: A0A060JCT2
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

529884:RHOLA RS04320
gene id: 529884:RHOLA_RS04320
uniprot id: A0A060JG50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

529884:RHOLA RS05705
gene id: 529884:RHOLA_RS05705
uniprot id: A0A060JHB2
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS02750
gene id: 529884:RHOLA_RS02750
uniprot id: A0A060JL93
names: Similarity
messages: Belongs to the glutathione peroxidase family.

529884:RHOLA RS03615
gene id: 529884:RHOLA_RS03615
uniprot id: A0A060JG42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

529884:RHOLA RS02275
gene id: 529884:RHOLA_RS02275
uniprot id: A0A060JFF2
names: Similarity
messages: Belongs to the ribF family.

529884:RHOLA RS05290
gene id: 529884:RHOLA_RS05290
uniprot id: A0A060JGJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00695
gene id: 529884:RHOLA_RS00695
uniprot id: A0A060JDY3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

529884:RHOLA RS01425
gene id: 529884:RHOLA_RS01425
uniprot id: A0A060JLI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS05095
gene id: 529884:RHOLA_RS05095
uniprot id: A0A060JML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

529884:RHOLA RS02585
gene id: 529884:RHOLA_RS02585
uniprot id: A0A060JFJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

529884:RHOLA RS02930
gene id: 529884:RHOLA_RS02930
uniprot id: A0A060JFQ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

529884:RHOLA RS06140
gene id: 529884:RHOLA_RS06140
uniprot id: A0A060JN62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

529884:RHOLA RS02680
gene id: 529884:RHOLA_RS02680
uniprot id: A0A060JBV1
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

529884:RHOLA RS03060
gene id: 529884:RHOLA_RS03060
uniprot id: A0A060JFS8
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

529884:RHOLA RS03535
gene id: 529884:RHOLA_RS03535
uniprot id: A0A060JCB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

529884:RHOLA RS04230
gene id: 529884:RHOLA_RS04230
uniprot id: A0A060JGM4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

529884:RHOLA RS05355
gene id: 529884:RHOLA_RS05355
uniprot id: A0A060JDB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS05810
gene id: 529884:RHOLA_RS05810
uniprot id: A0A060JMZ8
names: Similarity
messages: Belongs to the CmpA/NrtA family.

529884:RHOLA RS00145
gene id: 529884:RHOLA_RS00145
uniprot id: A0A060JDM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

529884:RHOLA RS06825
gene id: 529884:RHOLA_RS06825
uniprot id: A0A060JPV0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

529884:RHOLA RS05410
gene id: 529884:RHOLA_RS05410
uniprot id: A0A060JMS0
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS05575
gene id: 529884:RHOLA_RS05575
uniprot id: A0A060JDG6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

529884:RHOLA RS05645
gene id: 529884:RHOLA_RS05645
uniprot id: A0A060JGR7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

529884:RHOLA RS04275
gene id: 529884:RHOLA_RS04275
uniprot id: A0A060JCV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02455
gene id: 529884:RHOLA_RS02455
uniprot id: A0A060JL36
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

529884:RHOLA RS02045
gene id: 529884:RHOLA_RS02045
uniprot id: A0A060JBJ9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

529884:RHOLA RS03700
gene id: 529884:RHOLA_RS03700
uniprot id: A0A060JMU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

529884:RHOLA RS03725
gene id: 529884:RHOLA_RS03725
uniprot id: A0A060JMV2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

529884:RHOLA RS02055
gene id: 529884:RHOLA_RS02055
uniprot id: A0A060JKW9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06175
gene id: 529884:RHOLA_RS06175
uniprot id: A0A060JH37
names: Similarity
messages: Belongs to the pirin family.

529884:RHOLA RS02875
gene id: 529884:RHOLA_RS02875
uniprot id: A0A060JBY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

529884:RHOLA RS04705
gene id: 529884:RHOLA_RS04705
uniprot id: A0A060JD06
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

529884:RHOLA RS01820
gene id: 529884:RHOLA_RS01820
uniprot id: A0A060JKT6
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

529884:RHOLA RS02090
gene id: 529884:RHOLA_RS02090
uniprot id: A0A060JER5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

529884:RHOLA RS02180
gene id: 529884:RHOLA_RS02180
uniprot id: A0A060JKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS05700
gene id: 529884:RHOLA_RS05700
uniprot id: A0A060JDJ2
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS00795
gene id: 529884:RHOLA_RS00795
uniprot id: A0A060JEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

529884:RHOLA RS02945
gene id: 529884:RHOLA_RS02945
uniprot id: A0A060JF72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

529884:RHOLA RS02805
gene id: 529884:RHOLA_RS02805
uniprot id: A0A060JM94
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

529884:RHOLA RS00385
gene id: 529884:RHOLA_RS00385
uniprot id: A0A060JE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS03095
gene id: 529884:RHOLA_RS03095
uniprot id: A0A060JMF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS06755
gene id: 529884:RHOLA_RS06755
uniprot id: A0A060JHJ5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

529884:RHOLA RS02305
gene id: 529884:RHOLA_RS02305
uniprot id: A0A060JL10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

529884:RHOLA RS02105
gene id: 529884:RHOLA_RS02105
uniprot id: A0A060JKX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

529884:RHOLA RS04625
gene id: 529884:RHOLA_RS04625
uniprot id: A0A060JG90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

529884:RHOLA RS01625
gene id: 529884:RHOLA_RS01625
uniprot id: A0A060JLQ6
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

529884:RHOLA RS02540
gene id: 529884:RHOLA_RS02540
uniprot id: A0A060JL50
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

529884:RHOLA RS05770
gene id: 529884:RHOLA_RS05770
uniprot id: A0A060JGU5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02185
gene id: 529884:RHOLA_RS02185
uniprot id: A0A060JLZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

529884:RHOLA RS01855
gene id: 529884:RHOLA_RS01855
uniprot id: A0A060JEM9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS06025
gene id: 529884:RHOLA_RS06025
uniprot id: A0A060JGZ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS04720
gene id: 529884:RHOLA_RS04720
uniprot id: A0A060JNI3
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS06210
gene id: 529884:RHOLA_RS06210
uniprot id: A0A060JHM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

529884:RHOLA RS03630
gene id: 529884:RHOLA_RS03630
uniprot id: A0A060JFL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

529884:RHOLA RS04975
gene id: 529884:RHOLA_RS04975
uniprot id: A0A060JD47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03225
gene id: 529884:RHOLA_RS03225
uniprot id: A0A060JLI7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

529884:RHOLA RS03855
gene id: 529884:RHOLA_RS03855
uniprot id: A0A060JMY2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

529884:RHOLA RS02745
gene id: 529884:RHOLA_RS02745
uniprot id: A0A060JFM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

529884:RHOLA RS03545
gene id: 529884:RHOLA_RS03545
uniprot id: A0A060JLP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

529884:RHOLA RS00040
gene id: 529884:RHOLA_RS00040
uniprot id: A0A060JAD5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

529884:RHOLA RS05205
gene id: 529884:RHOLA_RS05205
uniprot id: A0A060JMN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

529884:RHOLA RS01340
gene id: 529884:RHOLA_RS01340
uniprot id: A0A060JEV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

529884:RHOLA RS03450
gene id: 529884:RHOLA_RS03450
uniprot id: A0A060JG08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

529884:RHOLA RS01045
gene id: 529884:RHOLA_RS01045
uniprot id: A0A060JL99
names: Similarity
messages: Belongs to the isochorismate synthase family.

529884:RHOLA RS06895
gene id: 529884:RHOLA_RS06895
uniprot id: A0A060JPW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

529884:RHOLA RS03120
gene id: 529884:RHOLA_RS03120
uniprot id: A0A060JMF8
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

529884:RHOLA RS05100
gene id: 529884:RHOLA_RS05100
uniprot id: A0A060JNP3
names: Similarity
messages: Belongs to the YciI family.

529884:RHOLA RS06155
gene id: 529884:RHOLA_RS06155
uniprot id: A0A060JDU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

529884:RHOLA RS02065
gene id: 529884:RHOLA_RS02065
uniprot id: A0A060JER1
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

529884:RHOLA RS03445
gene id: 529884:RHOLA_RS03445
uniprot id: A0A060JC97
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

529884:RHOLA RS02980
gene id: 529884:RHOLA_RS02980
uniprot id: A0A060JC01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

529884:RHOLA RS03065
gene id: 529884:RHOLA_RS03065
uniprot id: A0A060JLF7
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

529884:RHOLA RS05735
gene id: 529884:RHOLA_RS05735
uniprot id: A0A060JMY5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

529884:RHOLA RS02245
gene id: 529884:RHOLA_RS02245
uniprot id: A0A060JBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

529884:RHOLA RS05695
gene id: 529884:RHOLA_RS05695
uniprot id: A0A060JGS8
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

529884:RHOLA RS00585
gene id: 529884:RHOLA_RS00585
uniprot id: A0A060JED3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

529884:RHOLA RS04835
gene id: 529884:RHOLA_RS04835
uniprot id: A0A060JD23
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

529884:RHOLA RS01935
gene id: 529884:RHOLA_RS01935
uniprot id: A0A060JBI9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

529884:RHOLA RS05775
gene id: 529884:RHOLA_RS05775
uniprot id: A0A060JDK8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

529884:RHOLA RS01715
gene id: 529884:RHOLA_RS01715
uniprot id: A0A060JF64
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

529884:RHOLA RS02030
gene id: 529884:RHOLA_RS02030
uniprot id: A0A060JKW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS03905
gene id: 529884:RHOLA_RS03905
uniprot id: A0A060JMZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

529884:RHOLA RS01290
gene id: 529884:RHOLA_RS01290
uniprot id: A0A060JEU0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

529884:RHOLA RS04800
gene id: 529884:RHOLA_RS04800
uniprot id: A0A060JGB5
names: Similarity
messages: Belongs to the TPP enzyme family.

529884:RHOLA RS04565
gene id: 529884:RHOLA_RS04565
uniprot id: A0A060JNF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

529884:RHOLA RS01280
gene id: 529884:RHOLA_RS01280
uniprot id: A0A060JE94
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

529884:RHOLA RS02205
gene id: 529884:RHOLA_RS02205
uniprot id: A0A060JKZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

529884:RHOLA RS06150
gene id: 529884:RHOLA_RS06150
uniprot id: A0A060JH29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

529884:RHOLA RS01285
gene id: 529884:RHOLA_RS01285
uniprot id: A0A060JB49
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS03305
gene id: 529884:RHOLA_RS03305
uniprot id: A0A060JLK2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00655
gene id: 529884:RHOLA_RS00655
uniprot id: A0A060JAQ3
names: Similarity
messages: Belongs to the CsoR family.

529884:RHOLA RS01105
gene id: 529884:RHOLA_RS01105
uniprot id: A0A060JE58
names: Subcellular Location Annotation
messages: Membrane

529884:RHOLA RS03620
gene id: 529884:RHOLA_RS03620
uniprot id: A0A060JLR9
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

529884:RHOLA RS05425
gene id: 529884:RHOLA_RS05425
uniprot id: A0A060JDD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

529884:RHOLA RS07115
gene id: 529884:RHOLA_RS07115
uniprot id: A0A060JMM0
names: Similarity
messages: Belongs to the peptidase C40 family.

529884:RHOLA RS01880
gene id: 529884:RHOLA_RS01880
uniprot id: A0A060JEN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

529884:RHOLA RS05045
gene id: 529884:RHOLA_RS05045
uniprot id: A0A060JNN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

529884:RHOLA RS00915
gene id: 529884:RHOLA_RS00915
uniprot id: A0A060JAW3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

529884:RHOLA RS06805
gene id: 529884:RHOLA_RS06805
uniprot id: A0A060JHK3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

529884:RHOLA RS01015
gene id: 529884:RHOLA_RS01015
uniprot id: A0A060JK88
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS06810
gene id: 529884:RHOLA_RS06810
uniprot id: A0A060JE99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

529884:RHOLA RS02500
gene id: 529884:RHOLA_RS02500
uniprot id: A0A060JFI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

529884:RHOLA RS03550
gene id: 529884:RHOLA_RS03550
uniprot id: A0A060JMQ9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

529884:RHOLA RS02125
gene id: 529884:RHOLA_RS02125
uniprot id: A0A060JFC7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

529884:RHOLA RS02780
gene id: 529884:RHOLA_RS02780
uniprot id: A0A060JM88
names: Similarity
messages: Belongs to the group II decarboxylase family.

529884:RHOLA RS00280
gene id: 529884:RHOLA_RS00280
uniprot id: A0A060JE77
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

529884:RHOLA RS04515
gene id: 529884:RHOLA_RS04515
uniprot id: A0A060JNF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

529884:RHOLA RS04360
gene id: 529884:RHOLA_RS04360
uniprot id: A0A060JM93
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

529884:RHOLA RS01445
gene id: 529884:RHOLA_RS01445
uniprot id: A0A060JKJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS02595
gene id: 529884:RHOLA_RS02595
uniprot id: A0A060JM58
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS00325
gene id: 529884:RHOLA_RS00325
uniprot id: A0A060JAI4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

529884:RHOLA RS04920
gene id: 529884:RHOLA_RS04920
uniprot id: A0A060JNL0
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.

529884:RHOLA RS06765
gene id: 529884:RHOLA_RS06765
uniprot id: A0A060JI50
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

529884:RHOLA RS03110
gene id: 529884:RHOLA_RS03110
uniprot id: A0A060JFT6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

529884:RHOLA RS05685
gene id: 529884:RHOLA_RS05685
uniprot id: A0A060JMX5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

529884:RHOLA RS01590
gene id: 529884:RHOLA_RS01590
uniprot id: A0A060JF39
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

529884:RHOLA RS01235
gene id: 529884:RHOLA_RS01235
uniprot id: A0A060JKE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

529884:RHOLA RS04615
gene id: 529884:RHOLA_RS04615
uniprot id: A0A060JMD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

529884:RHOLA RS06555
gene id: 529884:RHOLA_RS06555
uniprot id: A0A060JHY1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

529884:RHOLA RS00035
gene id: 529884:RHOLA_RS00035
uniprot id: A0A060JDK2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.