523850:TON RS02800
gene id: 523850:TON_RS02800
uniprot id: B6YU85
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523850:TON RS06635
gene id: 523850:TON_RS06635
uniprot id: B6YXI9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523850:TON RS04090
gene id: 523850:TON_RS04090
uniprot id: B6YVW1
names: Similarity
messages: Belongs to the UPF0166 family.

523850:TON RS01365
gene id: 523850:TON_RS01365
uniprot id: B6YT57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

523850:TON RS07245
gene id: 523850:TON_RS07245
uniprot id: B6YXU9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

523850:TON RS01935
gene id: 523850:TON_RS01935
uniprot id: B6YTG7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523850:TON RS07240
gene id: 523850:TON_RS07240
uniprot id: B6YXU8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

523850:TON RS01275
gene id: 523850:TON_RS01275
uniprot id: B6YT38
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03320
gene id: 523850:TON_RS03320
uniprot id: B6YUU5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

523850:TON RS07605
gene id: 523850:TON_RS07605
uniprot id: B6YY19
names: Similarity
messages: Belongs to the UPF0215 family.

523850:TON RS05005
gene id: 523850:TON_RS05005
uniprot id: B6YWK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

523850:TON RS01115
gene id: 523850:TON_RS01115
uniprot id: B6YT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

523850:TON RS00305
gene id: 523850:TON_RS00305
uniprot id: B6YSK8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS07310
gene id: 523850:TON_RS07310
uniprot id: B6YXW2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS05660
gene id: 523850:TON_RS05660
uniprot id: B6YWY4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

523850:TON RS09100
gene id: 523850:TON_RS09100
uniprot id: B6YV49
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00450
gene id: 523850:TON_RS00450
uniprot id: B6YSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

523850:TON RS00440
gene id: 523850:TON_RS00440
uniprot id: B6YSN5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

523850:TON RS08340
gene id: 523850:TON_RS08340
uniprot id: B6YUD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

523850:TON RS08425
gene id: 523850:TON_RS08425
uniprot id: B6YUF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

523850:TON RS06260
gene id: 523850:TON_RS06260
uniprot id: B6YXB1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523850:TON RS08320
gene id: 523850:TON_RS08320
uniprot id: B6YUD5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

523850:TON RS03945
gene id: 523850:TON_RS03945
uniprot id: B6YVT2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

523850:TON RS08290
gene id: 523850:TON_RS08290
uniprot id: B6YUC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

523850:TON RS08700
gene id: 523850:TON_RS08700
uniprot id: B6YUW6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

523850:TON RS00210
gene id: 523850:TON_RS00210
uniprot id: B6YSI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523850:TON RS02775
gene id: 523850:TON_RS02775
uniprot id: B6YU81
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

523850:TON RS06300
gene id: 523850:TON_RS06300
uniprot id: B6YXB9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

523850:TON RS08690
gene id: 523850:TON_RS08690
uniprot id: B6YUW4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS01880
gene id: 523850:TON_RS01880
uniprot id: B6YTF7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523850:TON RS05720
gene id: 523850:TON_RS05720
uniprot id: B6YWZ9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

523850:TON RS10050
gene id: 523850:TON_RS10050
uniprot id: B6YW92
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

523850:TON RS02355
gene id: 523850:TON_RS02355
uniprot id: B6YTZ6
names: Function
messages: Probably involved in the biogenesis of the ribosome.

523850:TON RS08330
gene id: 523850:TON_RS08330
uniprot id: B6YUD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

523850:TON RS08360
gene id: 523850:TON_RS08360
uniprot id: B6YUE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

523850:TON RS08565
gene id: 523850:TON_RS08565
uniprot id: B6YUI3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523850:TON RS06125
gene id: 523850:TON_RS06125
uniprot id: B6YX84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523850:TON RS06645
gene id: 523850:TON_RS06645
uniprot id: B6YXJ1
names: Similarity
messages: Belongs to the UPF0173 family.

523850:TON RS05495
gene id: 523850:TON_RS05495
uniprot id: B6YWU9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

523850:TON RS05245
gene id: 523850:TON_RS05245
uniprot id: B6YWQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS06800
gene id: 523850:TON_RS06800
uniprot id: B6YXM2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09925
gene id: 523850:TON_RS09925
uniprot id: B6YW70
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

523850:TON RS09025
gene id: 523850:TON_RS09025
uniprot id: B6YV34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

523850:TON RS08065
gene id: 523850:TON_RS08065
uniprot id: B6YTX8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS01305
gene id: 523850:TON_RS01305
uniprot id: B6YT44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Cytoplasm

523850:TON RS00985
gene id: 523850:TON_RS00985
uniprot id: B6YSY5
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

523850:TON RS07675
gene id: 523850:TON_RS07675
uniprot id: B6YTQ4
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

523850:TON RS03960
gene id: 523850:TON_RS03960
uniprot id: B6YVT5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

523850:TON RS03610
gene id: 523850:TON_RS03610
uniprot id: B6YVB1
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

523850:TON RS06575
gene id: 523850:TON_RS06575
uniprot id: B6YXH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

523850:TON RS00410
gene id: 523850:TON_RS00410
uniprot id: B6YSM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523850:TON RS08390
gene id: 523850:TON_RS08390
uniprot id: B6YUE9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523850:TON RS03900
gene id: 523850:TON_RS03900
uniprot id: B6YVG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

523850:TON RS03325
gene id: 523850:TON_RS03325
uniprot id: B6YUU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

523850:TON RS03185
gene id: 523850:TON_RS03185
uniprot id: B6YUR8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

523850:TON RS03845
gene id: 523850:TON_RS03845
uniprot id: B6YVF6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

523850:TON RS01285
gene id: 523850:TON_RS01285
uniprot id: B6YT40
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02090
gene id: 523850:TON_RS02090
uniprot id: B6YTJ7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

523850:TON RS05195
gene id: 523850:TON_RS05195
uniprot id: B6YWP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

523850:TON RS03925
gene id: 523850:TON_RS03925
uniprot id: B6YVS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523850:TON RS04570
gene id: 523850:TON_RS04570
uniprot id: B6YWB8
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single-strand deoxyribonuclease (ssDNase) which digests linear and circular ssDNA; has 5'-3' and 3'-5' exonuclease activity as well as a less efficient endonuclease activity. Has a minimal size requirement; 100 nucleotide ssDNA (nt) is more efficiently digested than 50 or 25 nt ssDNA, while 14 nt ssDNA is not cleaved at all. It has no activity on dsDNA or ssRNA.
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Ni(2+) and Mn(2+), but not Mg(2+), Ca(2+), Zn(2+), Co(2+), or Cu(2+), is required for ssDNase activity.
messages: Probably part of the Csm effector complex, that includes Cas10, Csm2, Csm3, Csm4, Csm5 and mature crRNA (By similarity). Will form a homodimer in solution, interacts with Csm4, which is a tighter, better association than the homodimeric Cas10 and uses the same interface for interaction (PubMed:25773141).
messages: The N-terminal HD domain has ssDNase activity (PubMed:25773141). The C-terminal GGDEF domain has the cOA synthesis activity (By similarity).
messages: When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
messages: ssDNase activity is inhibited by EDTA.
messages: ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases.

523850:TON RS03345
gene id: 523850:TON_RS03345
uniprot id: B6YUV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

523850:TON RS08680
gene id: 523850:TON_RS08680
uniprot id: B6YUW3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

523850:TON RS06580
gene id: 523850:TON_RS06580
uniprot id: B6YXH7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

523850:TON RS07810
gene id: 523850:TON_RS07810
uniprot id: B6YTS7
names: Similarity
messages: Belongs to the UPF0147 family.

523850:TON RS01265
gene id: 523850:TON_RS01265
uniprot id: B6YT36
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

523850:TON RS01375
gene id: 523850:TON_RS01375
uniprot id: B6YT59
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

523850:TON RS03890
gene id: 523850:TON_RS03890
uniprot id: B6YVG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

523850:TON RS00950
gene id: 523850:TON_RS00950
uniprot id: B6YSX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523850:TON RS00760
gene id: 523850:TON_RS00760
uniprot id: B6YSU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

523850:TON RS01725
gene id: 523850:TON_RS01725
uniprot id: B6YTC9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

523850:TON RS04850
gene id: 523850:TON_RS04850
uniprot id: B6YWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

523850:TON RS02215
gene id: 523850:TON_RS02215
uniprot id: B6YTM3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

523850:TON RS00455
gene id: 523850:TON_RS00455
uniprot id: B6YSN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

523850:TON RS05675
gene id: 523850:TON_RS05675
uniprot id: B6YWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523850:TON RS09705
gene id: 523850:TON_RS09705
uniprot id: B6YVS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

523850:TON RS09090
gene id: 523850:TON_RS09090
uniprot id: B6YV47
names: Similarity
messages: Belongs to the peptidase M20A family.

523850:TON RS10005
gene id: 523850:TON_RS10005
uniprot id: B6YW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

523850:TON RS06230
gene id: 523850:TON_RS06230
uniprot id: B6YXA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

523850:TON RS00880
gene id: 523850:TON_RS00880
uniprot id: B6YSW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

523850:TON RS00170
gene id: 523850:TON_RS00170
uniprot id: B6YSF0
names: Similarity
messages: Belongs to the ZPR1 family.

523850:TON RS03735
gene id: 523850:TON_RS03735
uniprot id: B6YVD4
names: Similarity
messages: Belongs to the IMPACT family.

523850:TON RS08880
gene id: 523850:TON_RS08880
uniprot id: B6YV04
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

523850:TON RS05215
gene id: 523850:TON_RS05215
uniprot id: B6YWP7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00470
gene id: 523850:TON_RS00470
uniprot id: B6YSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

523850:TON RS09930
gene id: 523850:TON_RS09930
uniprot id: B6YW71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

523850:TON RS07755
gene id: 523850:TON_RS07755
uniprot id: B6YTR7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

523850:TON RS07640
gene id: 523850:TON_RS07640
uniprot id: B6YTP7
names: Similarity
messages: Belongs to the AOR/FOR family.

523850:TON RS00575
gene id: 523850:TON_RS00575
uniprot id: B6YSQ9
names: Similarity
messages: Belongs to the enolase family.

523850:TON RS00975
gene id: 523850:TON_RS00975
uniprot id: B6YSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523850:TON RS02300
gene id: 523850:TON_RS02300
uniprot id: B6YTP0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523850:TON RS02705
gene id: 523850:TON_RS02705
uniprot id: B6YU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

523850:TON RS00700
gene id: 523850:TON_RS00700
uniprot id: B6YST1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS01900
gene id: 523850:TON_RS01900
uniprot id: B6YTG0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. The enzyme is active with cobalt, nickel, manganese and divalent iron ions.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

523850:TON RS07460
gene id: 523850:TON_RS07460
uniprot id: B6YXZ0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523850:TON RS01430
gene id: 523850:TON_RS01430
uniprot id: B6YT70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS00770
gene id: 523850:TON_RS00770
uniprot id: B6YSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523850:TON RS07715
gene id: 523850:TON_RS07715
uniprot id: B6YTR0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

523850:TON RS04520
gene id: 523850:TON_RS04520
uniprot id: B6YWA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

523850:TON RS02075
gene id: 523850:TON_RS02075
uniprot id: B6YTJ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523850:TON RS00405
gene id: 523850:TON_RS00405
uniprot id: B6YSM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

523850:TON RS04610
gene id: 523850:TON_RS04610
uniprot id: B6YWC6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08515
gene id: 523850:TON_RS08515
uniprot id: B6YUH4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02885
gene id: 523850:TON_RS02885
uniprot id: B6YUK8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS06715
gene id: 523850:TON_RS06715
uniprot id: B6YXK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS05900
gene id: 523850:TON_RS05900
uniprot id: B6YX39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

523850:TON RS04885
gene id: 523850:TON_RS04885
uniprot id: B6YWI3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

523850:TON RS06465
gene id: 523850:TON_RS06465
uniprot id: B6YXF3
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

523850:TON RS09160
gene id: 523850:TON_RS09160
uniprot id: B6YV61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523850:TON RS09460
gene id: 523850:TON_RS09460
uniprot id: B6YVM3
names: Similarity
messages: Belongs to the thymidylate kinase family.

523850:TON RS07265
gene id: 523850:TON_RS07265
uniprot id: B6YXV3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523850:TON RS00710
gene id: 523850:TON_RS00710
uniprot id: B6YST3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

523850:TON RS03525
gene id: 523850:TON_RS03525
uniprot id: B6YV94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

523850:TON RS04020
gene id: 523850:TON_RS04020
uniprot id: B6YVU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

523850:TON RS06245
gene id: 523850:TON_RS06245
uniprot id: B6YXA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

523850:TON RS06735
gene id: 523850:TON_RS06735
uniprot id: B6YXK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS00340
gene id: 523850:TON_RS00340
uniprot id: B6YSL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

523850:TON RS00360
gene id: 523850:TON_RS00360
uniprot id: B6YSL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

523850:TON RS00690
gene id: 523850:TON_RS00690
uniprot id: B6YSS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

523850:TON RS07585
gene id: 523850:TON_RS07585
uniprot id: B6YY15
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523850:TON RS02345
gene id: 523850:TON_RS02345
uniprot id: B6YTZ3
names: Similarity
messages: Belongs to the UPF0440 family.

523850:TON RS05650
gene id: 523850:TON_RS05650
uniprot id: B6YWY2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

523850:TON RS01315
gene id: 523850:TON_RS01315
uniprot id: B6YT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

523850:TON RS02380
gene id: 523850:TON_RS02380
uniprot id: B6YU01
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS01845
gene id: 523850:TON_RS01845
uniprot id: B6YTF0
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

523850:TON RS06890
gene id: 523850:TON_RS06890
uniprot id: B6YXN8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523850:TON RS01290
gene id: 523850:TON_RS01290
uniprot id: B6YT41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523850:TON RS07595
gene id: 523850:TON_RS07595
uniprot id: B6YY17
names: Similarity
messages: Belongs to the acylphosphatase family.

523850:TON RS01730
gene id: 523850:TON_RS01730
uniprot id: B6YTD0
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

523850:TON RS06335
gene id: 523850:TON_RS06335
uniprot id: B6YXC7
names: Subcellular Location Annotation
messages: Cytoplasm

523850:TON RS00525
gene id: 523850:TON_RS00525
uniprot id: B6YSQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

523850:TON RS02925
gene id: 523850:TON_RS02925
uniprot id: B6YUL6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS07040
gene id: 523850:TON_RS07040
uniprot id: B6YXR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

523850:TON RS00345
gene id: 523850:TON_RS00345
uniprot id: B6YSL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

523850:TON RS07385
gene id: 523850:TON_RS07385
uniprot id: B6YXX6
names: Similarity
messages: Belongs to the BtpA family.

523850:TON RS00920
gene id: 523850:TON_RS00920
uniprot id: B6YSX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

523850:TON RS00530
gene id: 523850:TON_RS00530
uniprot id: B6YSQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523850:TON RS08610
gene id: 523850:TON_RS08610
uniprot id: B6YUJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

523850:TON RS04745
gene id: 523850:TON_RS04745
uniprot id: B6YWF4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

523850:TON RS05255
gene id: 523850:TON_RS05255
uniprot id: B6YWQ4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08195
gene id: 523850:TON_RS08195
uniprot id: B6YUB0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS05235
gene id: 523850:TON_RS05235
uniprot id: B6YWQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS01645
gene id: 523850:TON_RS01645
uniprot id: B6YTB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

523850:TON RS00460
gene id: 523850:TON_RS00460
uniprot id: B6YSN9
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS06900
gene id: 523850:TON_RS06900
uniprot id: B6YXP0
names: Similarity
messages: Belongs to the UPF0282 family.

523850:TON RS08285
gene id: 523850:TON_RS08285
uniprot id: B6YUC8
names: Similarity
messages: Belongs to the MoaD family.

523850:TON RS09865
gene id: 523850:TON_RS09865
uniprot id: B6YW58
names: Similarity
messages: Belongs to the UPF0145 family.

523850:TON RS07575
gene id: 523850:TON_RS07575
uniprot id: B6YY13
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

523850:TON RS07430
gene id: 523850:TON_RS07430
uniprot id: B6YXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

523850:TON RS00695
gene id: 523850:TON_RS00695
uniprot id: B6YST0
names: Similarity
messages: Belongs to the MEMO1 family.

523850:TON RS01175
gene id: 523850:TON_RS01175
uniprot id: B6YT20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

523850:TON RS08925
gene id: 523850:TON_RS08925
uniprot id: B6YV13
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523850:TON RS07550
gene id: 523850:TON_RS07550
uniprot id: B6YY08
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS06355
gene id: 523850:TON_RS06355
uniprot id: B6YXD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS04620
gene id: 523850:TON_RS04620
uniprot id: B6YWC8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

523850:TON RS03020
gene id: 523850:TON_RS03020
uniprot id: B6YUN5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS05050
gene id: 523850:TON_RS05050
uniprot id: B6YWL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

523850:TON RS03050
gene id: 523850:TON_RS03050
uniprot id: B6YUP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

523850:TON RS00860
gene id: 523850:TON_RS00860
uniprot id: B6YSW2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523850:TON RS05625
gene id: 523850:TON_RS05625
uniprot id: B6YWX7
names: Similarity
messages: Belongs to the PDCD5 family.

523850:TON RS06405
gene id: 523850:TON_RS06405
uniprot id: B6YXD9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS10000
gene id: 523850:TON_RS10000
uniprot id: B6YW82
names: Similarity
messages: Belongs to the DtxR/MntR family.

523850:TON RS09870
gene id: 523850:TON_RS09870
uniprot id: B6YW59
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

523850:TON RS04445
gene id: 523850:TON_RS04445
uniprot id: B6YW33
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

523850:TON RS08470
gene id: 523850:TON_RS08470
uniprot id: B6YUG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523850:TON RS06080
gene id: 523850:TON_RS06080
uniprot id: B6YX76
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

523850:TON RS01405
gene id: 523850:TON_RS01405
uniprot id: B6YT65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS04000
gene id: 523850:TON_RS04000
uniprot id: B6YVU3
names: Similarity
messages: Belongs to the UPF0045 family.

523850:TON RS04010
gene id: 523850:TON_RS04010
uniprot id: B6YVU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

523850:TON RS03875
gene id: 523850:TON_RS03875
uniprot id: B6YVG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523850:TON RS02450
gene id: 523850:TON_RS02450
uniprot id: B6YU16
names: Similarity
messages: Belongs to the glutaredoxin family.

523850:TON RS01055
gene id: 523850:TON_RS01055
uniprot id: B6YT00
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

523850:TON RS07475
gene id: 523850:TON_RS07475
uniprot id: B6YXZ3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

523850:TON RS03005
gene id: 523850:TON_RS03005
uniprot id: B6YUN2
names: Similarity
messages: Belongs to the UPF0127 family.

523850:TON RS07660
gene id: 523850:TON_RS07660
uniprot id: B6YTQ1
names: Similarity
messages: Belongs to the carbamate kinase family.

523850:TON RS08975
gene id: 523850:TON_RS08975
uniprot id: B6YV24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

523850:TON RS05165
gene id: 523850:TON_RS05165
uniprot id: B6YWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

523850:TON RS09180
gene id: 523850:TON_RS09180
uniprot id: B6YV65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

523850:TON RS03545
gene id: 523850:TON_RS03545
uniprot id: B6YV98
names: Similarity
messages: Belongs to the UPF0284 family.

523850:TON RS01760
gene id: 523850:TON_RS01760
uniprot id: B6YTD6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

523850:TON RS08995
gene id: 523850:TON_RS08995
uniprot id: B6YV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS05330
gene id: 523850:TON_RS05330
uniprot id: B6YWR7
names: Similarity
messages: Belongs to the DEAD box helicase family.

523850:TON RS01795
gene id: 523850:TON_RS01795
uniprot id: B6YTE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

523850:TON RS02560
gene id: 523850:TON_RS02560
uniprot id: B6YU38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS08140
gene id: 523850:TON_RS08140
uniprot id: B6YU99
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00010
gene id: 523850:TON_RS00010
uniprot id: B6YSF3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523850:TON RS03000
gene id: 523850:TON_RS03000
uniprot id: B6YUN1
names: Cofactor
messages: Binds 1 zinc ion per subunit.

523850:TON RS02790
gene id: 523850:TON_RS02790
uniprot id: B6YU83
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02360
gene id: 523850:TON_RS02360
uniprot id: B6YTZ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS07365
gene id: 523850:TON_RS07365
uniprot id: B6YXX2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

523850:TON RS10010
gene id: 523850:TON_RS10010
uniprot id: B6YW84
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09740
gene id: 523850:TON_RS09740
uniprot id: B6YW35
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

523850:TON RS01615
gene id: 523850:TON_RS01615
uniprot id: B6YTA9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

523850:TON RS01005
gene id: 523850:TON_RS01005
uniprot id: B6YSY9
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

523850:TON RS01665
gene id: 523850:TON_RS01665
uniprot id: B6YTB7
names: Similarity
messages: Belongs to the glutaredoxin family.

523850:TON RS05770
gene id: 523850:TON_RS05770
uniprot id: B6YX10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

523850:TON RS00355
gene id: 523850:TON_RS00355
uniprot id: B6YSL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

523850:TON RS03295
gene id: 523850:TON_RS03295
uniprot id: B6YUU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

523850:TON RS03450
gene id: 523850:TON_RS03450
uniprot id: B6YV80
names: Similarity
messages: Belongs to the peptidase U62 family.

523850:TON RS02365
gene id: 523850:TON_RS02365
uniprot id: B6YTZ8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

523850:TON RS09050
gene id: 523850:TON_RS09050
uniprot id: B6YV39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

523850:TON RS02630
gene id: 523850:TON_RS02630
uniprot id: B6YU52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

523850:TON RS06320
gene id: 523850:TON_RS06320
uniprot id: B6YXC4
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

523850:TON RS00825
gene id: 523850:TON_RS00825
uniprot id: B6YSV5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523850:TON RS03725
gene id: 523850:TON_RS03725
uniprot id: B6YVD2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS01260
gene id: 523850:TON_RS01260
uniprot id: B6YT35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523850:TON RS07480
gene id: 523850:TON_RS07480
uniprot id: B6YXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

523850:TON RS05595
gene id: 523850:TON_RS05595
uniprot id: B6YWX1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523850:TON RS03830
gene id: 523850:TON_RS03830
uniprot id: B6YVF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

523850:TON RS00225
gene id: 523850:TON_RS00225
uniprot id: B6YSJ2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523850:TON RS09245
gene id: 523850:TON_RS09245
uniprot id: B6YVI2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

523850:TON RS06440
gene id: 523850:TON_RS06440
uniprot id: B6YXE5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

523850:TON RS02730
gene id: 523850:TON_RS02730
uniprot id: B6YU72
names: Similarity
messages: Belongs to the RutC family.

523850:TON RS03630
gene id: 523850:TON_RS03630
uniprot id: B6YVB5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523850:TON RS09950
gene id: 523850:TON_RS09950
uniprot id: B6YW75
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

523850:TON RS01485
gene id: 523850:TON_RS01485
uniprot id: B6YT81
names: Similarity
messages: Belongs to the HupF/HypC family.

523850:TON RS04360
gene id: 523850:TON_RS04360
uniprot id: B6YW15
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

523850:TON RS05685
gene id: 523850:TON_RS05685
uniprot id: B6YWY9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523850:TON RS04630
gene id: 523850:TON_RS04630
uniprot id: B6YWD0
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04265
gene id: 523850:TON_RS04265
uniprot id: B6YVZ6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00945
gene id: 523850:TON_RS00945
uniprot id: B6YSX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

523850:TON RS00475
gene id: 523850:TON_RS00475
uniprot id: B6YSP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

523850:TON RS01145
gene id: 523850:TON_RS01145
uniprot id: B6YT14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS00390
gene id: 523850:TON_RS00390
uniprot id: B6YSM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

523850:TON RS02945
gene id: 523850:TON_RS02945
uniprot id: B6YUM0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523850:TON RS01835
gene id: 523850:TON_RS01835
uniprot id: B6YTE8
names: Similarity
messages: Belongs to the UPF0212 family.

523850:TON RS00060
gene id: 523850:TON_RS00060
uniprot id: B6YSG3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

523850:TON RS07865
gene id: 523850:TON_RS07865
uniprot id: B6YTT6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

523850:TON RS04205
gene id: 523850:TON_RS04205
uniprot id: B6YVY4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

523850:TON RS03985
gene id: 523850:TON_RS03985
uniprot id: B6YVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523850:TON RS07395
gene id: 523850:TON_RS07395
uniprot id: B6YXX8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523850:TON RS06085
gene id: 523850:TON_RS06085
uniprot id: B6YX77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

523850:TON RS09920
gene id: 523850:TON_RS09920
uniprot id: B6YW69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523850:TON RS06255
gene id: 523850:TON_RS06255
uniprot id: B6YXB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523850:TON RS09730
gene id: 523850:TON_RS09730
uniprot id: B6YVS5
names: Similarity
messages: Belongs to the peptidase S8 family.

523850:TON RS00665
gene id: 523850:TON_RS00665
uniprot id: B6YSS6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

523850:TON RS01925
gene id: 523850:TON_RS01925
uniprot id: B6YTG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

523850:TON RS06240
gene id: 523850:TON_RS06240
uniprot id: B6YXA7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

523850:TON RS08895
gene id: 523850:TON_RS08895
uniprot id: B6YV07
names: Function
messages: Part of a potassium transport system.

523850:TON RS01380
gene id: 523850:TON_RS01380
uniprot id: B6YT60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

523850:TON RS04585
gene id: 523850:TON_RS04585
uniprot id: B6YWC1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Csm4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Probably part of the Csm effector complex, that includes Cas10, Csm2, Csm3, Csm4, Csm5 and mature crRNA (By similarity). Interacts with Cas10 (csm1) (PubMed:25773141).
messages: The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self.

523850:TON RS09575
gene id: 523850:TON_RS09575
uniprot id: B6YVP3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

523850:TON RS06020
gene id: 523850:TON_RS06020
uniprot id: B6YX64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523850:TON RS04565
gene id: 523850:TON_RS04565
uniprot id: B6YWB7
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

523850:TON RS09150
gene id: 523850:TON_RS09150
uniprot id: B6YV59
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

523850:TON RS04945
gene id: 523850:TON_RS04945
uniprot id: B6YWJ4
names: Similarity
messages: Belongs to the peptidase S9C family.

523850:TON RS09750
gene id: 523850:TON_RS09750
uniprot id: B6YW37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

523850:TON RS07955
gene id: 523850:TON_RS07955
uniprot id: B6YTV6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

523850:TON RS08085
gene id: 523850:TON_RS08085
uniprot id: B6YTY2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS03385
gene id: 523850:TON_RS03385
uniprot id: B6YUV8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03695
gene id: 523850:TON_RS03695
uniprot id: B6YVC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

523850:TON RS02040
gene id: 523850:TON_RS02040
uniprot id: B6YTI8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02060
gene id: 523850:TON_RS02060
uniprot id: B6YTJ2
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

523850:TON RS05025
gene id: 523850:TON_RS05025
uniprot id: B6YWL0
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03180
gene id: 523850:TON_RS03180
uniprot id: B6YUR7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

523850:TON RS00435
gene id: 523850:TON_RS00435
uniprot id: B6YSN4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

523850:TON RS08060
gene id: 523850:TON_RS08060
uniprot id: B6YTX7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00600
gene id: 523850:TON_RS00600
uniprot id: B6YSR3
names: Similarity
messages: Belongs to the FUN14 family.

523850:TON RS01985
gene id: 523850:TON_RS01985
uniprot id: B6YTH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS09030
gene id: 523850:TON_RS09030
uniprot id: B6YV35
names: Similarity
messages: Belongs to the UPF0216 family.

523850:TON RS01155
gene id: 523850:TON_RS01155
uniprot id: B6YT16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS08300
gene id: 523850:TON_RS08300
uniprot id: B6YUD1
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS06790
gene id: 523850:TON_RS06790
uniprot id: B6YXM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

523850:TON RS08675
gene id: 523850:TON_RS08675
uniprot id: B6YUW2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523850:TON RS04440
gene id: 523850:TON_RS04440
uniprot id: B6YW32
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

523850:TON RS08715
gene id: 523850:TON_RS08715
uniprot id: B6YUW9
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

523850:TON RS03010
gene id: 523850:TON_RS03010
uniprot id: B6YUN3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS05800
gene id: 523850:TON_RS05800
uniprot id: B6YX16
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS04505
gene id: 523850:TON_RS04505
uniprot id: B6YWA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

523850:TON RS01875
gene id: 523850:TON_RS01875
uniprot id: B6YTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

523850:TON RS02995
gene id: 523850:TON_RS02995
uniprot id: B6YUN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

523850:TON RS03955
gene id: 523850:TON_RS03955
uniprot id: B6YVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523850:TON RS02310
gene id: 523850:TON_RS02310
uniprot id: B6YTP2
names: Similarity
messages: Belongs to the AOR/FOR family.

523850:TON RS06810
gene id: 523850:TON_RS06810
uniprot id: B6YXM4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS06915
gene id: 523850:TON_RS06915
uniprot id: B6YXP3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523850:TON RS01250
gene id: 523850:TON_RS01250
uniprot id: B6YT33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523850:TON RS03110
gene id: 523850:TON_RS03110
uniprot id: B6YUQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

523850:TON RS07835
gene id: 523850:TON_RS07835
uniprot id: B6YTT0
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

523850:TON RS04975
gene id: 523850:TON_RS04975
uniprot id: B6YWK0
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03795
gene id: 523850:TON_RS03795
uniprot id: B6YVE6
names: Similarity
messages: Belongs to the HypE family.

523850:TON RS09115
gene id: 523850:TON_RS09115
uniprot id: B6YV52
names: Similarity
messages: Belongs to the UPF0146 family.

523850:TON RS07925
gene id: 523850:TON_RS07925
uniprot id: B6YTV0
names: Similarity
messages: Belongs to the UPF0111 family.

523850:TON RS04750
gene id: 523850:TON_RS04750
uniprot id: B6YWF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

523850:TON RS00465
gene id: 523850:TON_RS00465
uniprot id: B6YSP0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

523850:TON RS01295
gene id: 523850:TON_RS01295
uniprot id: B6YT42
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523850:TON RS07545
gene id: 523850:TON_RS07545
uniprot id: B6YY07
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS02740
gene id: 523850:TON_RS02740
uniprot id: B6YU74
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

523850:TON RS05380
gene id: 523850:TON_RS05380
uniprot id: B6YWS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

523850:TON RS02220
gene id: 523850:TON_RS02220
uniprot id: B6YTM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

523850:TON RS04965
gene id: 523850:TON_RS04965
uniprot id: B6YWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

523850:TON RS07995
gene id: 523850:TON_RS07995
uniprot id: B6YTW4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07780
gene id: 523850:TON_RS07780
uniprot id: B6YTS2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS05175
gene id: 523850:TON_RS05175
uniprot id: B6YWP0
names: Similarity
messages: Belongs to the SfsA family.

523850:TON RS07730
gene id: 523850:TON_RS07730
uniprot id: B6YTR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS01390
gene id: 523850:TON_RS01390
uniprot id: B6YT62
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523850:TON RS01020
gene id: 523850:TON_RS01020
uniprot id: B6YSZ3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523850:TON RS03080
gene id: 523850:TON_RS03080
uniprot id: B6YUP7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08745
gene id: 523850:TON_RS08745
uniprot id: B6YUX5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523850:TON RS02505
gene id: 523850:TON_RS02505
uniprot id: B6YU27
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS09260
gene id: 523850:TON_RS09260
uniprot id: B6YVI5
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS01855
gene id: 523850:TON_RS01855
uniprot id: B6YTF2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

523850:TON RS02620
gene id: 523850:TON_RS02620
uniprot id: B6YU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523850:TON RS04525
gene id: 523850:TON_RS04525
uniprot id: B6YWA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

523850:TON RS08295
gene id: 523850:TON_RS08295
uniprot id: B6YUD0
names: Similarity
messages: Belongs to the GbsR family.

523850:TON RS00315
gene id: 523850:TON_RS00315
uniprot id: B6YSL0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

523850:TON RS08920
gene id: 523850:TON_RS08920
uniprot id: B6YV12
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523850:TON RS02695
gene id: 523850:TON_RS02695
uniprot id: B6YU65
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

523850:TON RS06500
gene id: 523850:TON_RS06500
uniprot id: B6YXG0
names: Similarity
messages: Belongs to the peptidase C56 family.

523850:TON RS09410
gene id: 523850:TON_RS09410
uniprot id: B6YVL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

523850:TON RS01500
gene id: 523850:TON_RS01500
uniprot id: B6YT85
names: Similarity
messages: Belongs to the HypE family.

523850:TON RS01700
gene id: 523850:TON_RS01700
uniprot id: B6YTC4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

523850:TON RS06455
gene id: 523850:TON_RS06455
uniprot id: B6YXF1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

523850:TON RS10040
gene id: 523850:TON_RS10040
uniprot id: B6YW90
names: Similarity
messages: Belongs to the UPF0045 family.

523850:TON RS09620
gene id: 523850:TON_RS09620
uniprot id: B6YVQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

523850:TON RS05435
gene id: 523850:TON_RS05435
uniprot id: B6YWT7
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

523850:TON RS06315
gene id: 523850:TON_RS06315
uniprot id: B6YXC3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

523850:TON RS00550
gene id: 523850:TON_RS00550
uniprot id: B6YSQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

523850:TON RS09560
gene id: 523850:TON_RS09560
uniprot id: B6YVP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523850:TON RS03365
gene id: 523850:TON_RS03365
uniprot id: B6YUV4
names: Similarity
messages: Belongs to the HypE family.

523850:TON RS09655
gene id: 523850:TON_RS09655
uniprot id: B6YVR0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523850:TON RS07300
gene id: 523850:TON_RS07300
uniprot id: B6YXW0
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09785
gene id: 523850:TON_RS09785
uniprot id: B6YW43
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04940
gene id: 523850:TON_RS04940
uniprot id: B6YWJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

523850:TON RS05965
gene id: 523850:TON_RS05965
uniprot id: B6YX53
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09755
gene id: 523850:TON_RS09755
uniprot id: B6YW38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

523850:TON RS01300
gene id: 523850:TON_RS01300
uniprot id: B6YT43
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

523850:TON RS00400
gene id: 523850:TON_RS00400
uniprot id: B6YSM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

523850:TON RS06330
gene id: 523850:TON_RS06330
uniprot id: B6YXC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

523850:TON RS03600
gene id: 523850:TON_RS03600
uniprot id: B6YVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

523850:TON RS01420
gene id: 523850:TON_RS01420
uniprot id: B6YT68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS06340
gene id: 523850:TON_RS06340
uniprot id: B6YXC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

523850:TON RS02180
gene id: 523850:TON_RS02180
uniprot id: B6YTL6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00645
gene id: 523850:TON_RS00645
uniprot id: B6YSS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523850:TON RS05550
gene id: 523850:TON_RS05550
uniprot id: B6YWW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

523850:TON RS01610
gene id: 523850:TON_RS01610
uniprot id: B6YTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523850:TON RS03305
gene id: 523850:TON_RS03305
uniprot id: B6YUU2
names: Similarity
messages: Belongs to the UPF0235 family.

523850:TON RS01085
gene id: 523850:TON_RS01085
uniprot id: B6YT06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS04675
gene id: 523850:TON_RS04675
uniprot id: B6YWD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523850:TON RS06060
gene id: 523850:TON_RS06060
uniprot id: B6YX72
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

523850:TON RS02275
gene id: 523850:TON_RS02275
uniprot id: B6YTN5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

523850:TON RS01010
gene id: 523850:TON_RS01010
uniprot id: B6YSZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS06935
gene id: 523850:TON_RS06935
uniprot id: B6YXP7
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

523850:TON RS00480
gene id: 523850:TON_RS00480
uniprot id: B6YSP3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523850:TON RS06860
gene id: 523850:TON_RS06860
uniprot id: B6YXN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

523850:TON RS09200
gene id: 523850:TON_RS09200
uniprot id: B6YVH3
names: Similarity
messages: Belongs to the AOR/FOR family.

523850:TON RS00270
gene id: 523850:TON_RS00270
uniprot id: B6YSK1
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

523850:TON RS09135
gene id: 523850:TON_RS09135
uniprot id: B6YV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS08785
gene id: 523850:TON_RS08785
uniprot id: B6YUY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523850:TON RS06200
gene id: 523850:TON_RS06200
uniprot id: B6YX99
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04240
gene id: 523850:TON_RS04240
uniprot id: B6YVZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

523850:TON RS00580
gene id: 523850:TON_RS00580
uniprot id: B6YSR0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

523850:TON RS04115
gene id: 523850:TON_RS04115
uniprot id: B6YVW6
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

523850:TON RS04500
gene id: 523850:TON_RS04500
uniprot id: B6YWA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

523850:TON RS06375
gene id: 523850:TON_RS06375
uniprot id: B6YXD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

523850:TON RS05060
gene id: 523850:TON_RS05060
uniprot id: B6YWL7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08250
gene id: 523850:TON_RS08250
uniprot id: B6YUC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

523850:TON RS06170
gene id: 523850:TON_RS06170
uniprot id: B6YX93
names: Similarity
messages: Belongs to the UPF0047 family.

523850:TON RS03400
gene id: 523850:TON_RS03400
uniprot id: B6YV69
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

523850:TON RS00385
gene id: 523850:TON_RS00385
uniprot id: B6YSM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

523850:TON RS07210
gene id: 523850:TON_RS07210
uniprot id: B6YXU2
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

523850:TON RS03440
gene id: 523850:TON_RS03440
uniprot id: B6YV78
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

523850:TON RS02580
gene id: 523850:TON_RS02580
uniprot id: B6YU42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS08035
gene id: 523850:TON_RS08035
uniprot id: B6YTX2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02910
gene id: 523850:TON_RS02910
uniprot id: B6YUL3
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

523850:TON RS06930
gene id: 523850:TON_RS06930
uniprot id: B6YXP6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

523850:TON RS01255
gene id: 523850:TON_RS01255
uniprot id: B6YT34
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

523850:TON RS04535
gene id: 523850:TON_RS04535
uniprot id: B6YWB1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

523850:TON RS09895
gene id: 523850:TON_RS09895
uniprot id: B6YW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523850:TON RS01800
gene id: 523850:TON_RS01800
uniprot id: B6YTE4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

523850:TON RS09660
gene id: 523850:TON_RS09660
uniprot id: B6YVR1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523850:TON RS03930
gene id: 523850:TON_RS03930
uniprot id: B6YVS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523850:TON RS03655
gene id: 523850:TON_RS03655
uniprot id: B6YVC0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523850:TON RS09525
gene id: 523850:TON_RS09525
uniprot id: B6YVN3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

523850:TON RS04800
gene id: 523850:TON_RS04800
uniprot id: B6YWG5
names: Similarity
messages: Belongs to the UPF0248 family.

523850:TON RS04340
gene id: 523850:TON_RS04340
uniprot id: B6YW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

523850:TON RS00420
gene id: 523850:TON_RS00420
uniprot id: B6YSN1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

523850:TON RS09645
gene id: 523850:TON_RS09645
uniprot id: B6YVQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

523850:TON RS01975
gene id: 523850:TON_RS01975
uniprot id: B6YTH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

523850:TON RS06960
gene id: 523850:TON_RS06960
uniprot id: B6YXQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

523850:TON RS02535
gene id: 523850:TON_RS02535
uniprot id: B6YU33
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

523850:TON RS00990
gene id: 523850:TON_RS00990
uniprot id: B6YSY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

523850:TON RS01630
gene id: 523850:TON_RS01630
uniprot id: B6YTB2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

523850:TON RS02915
gene id: 523850:TON_RS02915
uniprot id: B6YUL4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523850:TON RS04215
gene id: 523850:TON_RS04215
uniprot id: B6YVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS02540
gene id: 523850:TON_RS02540
uniprot id: B6YU34
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04175
gene id: 523850:TON_RS04175
uniprot id: B6YVX8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS05335
gene id: 523850:TON_RS05335
uniprot id: B6YWR8
names: Similarity
messages: Belongs to the UPF0252 family.

523850:TON RS00995
gene id: 523850:TON_RS00995
uniprot id: B6YSY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

523850:TON RS05680
gene id: 523850:TON_RS05680
uniprot id: B6YWY8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523850:TON RS01905
gene id: 523850:TON_RS01905
uniprot id: B6YTG1
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09230
gene id: 523850:TON_RS09230
uniprot id: B6YVH9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

523850:TON RS02400
gene id: 523850:TON_RS02400
uniprot id: B6YU05
names: Similarity
messages: Belongs to the RuvB family.

523850:TON RS02185
gene id: 523850:TON_RS02185
uniprot id: B6YTL7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

523850:TON RS07745
gene id: 523850:TON_RS07745
uniprot id: B6YTR5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

523850:TON RS06780
gene id: 523850:TON_RS06780
uniprot id: B6YXL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523850:TON RS03135
gene id: 523850:TON_RS03135
uniprot id: B6YUQ8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

523850:TON RS01805
gene id: 523850:TON_RS01805
uniprot id: B6YTE5
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

523850:TON RS06265
gene id: 523850:TON_RS06265
uniprot id: B6YXB2
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523850:TON RS07560
gene id: 523850:TON_RS07560
uniprot id: B6YY10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

523850:TON RS00365
gene id: 523850:TON_RS00365
uniprot id: B6YSM0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

523850:TON RS03660
gene id: 523850:TON_RS03660
uniprot id: B6YVC1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

523850:TON RS02225
gene id: 523850:TON_RS02225
uniprot id: B6YTM5
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00535
gene id: 523850:TON_RS00535
uniprot id: B6YSQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

523850:TON RS00425
gene id: 523850:TON_RS00425
uniprot id: B6YSN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523850:TON RS08870
gene id: 523850:TON_RS08870
uniprot id: B6YV02
names: Similarity
messages: Belongs to the UPF0273 family.

523850:TON RS04260
gene id: 523850:TON_RS04260
uniprot id: B6YVZ5
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02035
gene id: 523850:TON_RS02035
uniprot id: B6YTI7
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS02125
gene id: 523850:TON_RS02125
uniprot id: B6YTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

523850:TON RS09405
gene id: 523850:TON_RS09405
uniprot id: B6YVL3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

523850:TON RS08730
gene id: 523850:TON_RS08730
uniprot id: B6YUX2
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

523850:TON RS00150
gene id: 523850:TON_RS00150
uniprot id: B6YSI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

523850:TON RS06740
gene id: 523850:TON_RS06740
uniprot id: B6YXL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS00800
gene id: 523850:TON_RS00800
uniprot id: B6YSV0
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

523850:TON RS01170
gene id: 523850:TON_RS01170
uniprot id: B6YT19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

523850:TON RS07535
gene id: 523850:TON_RS07535
uniprot id: B6YY05
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS09760
gene id: 523850:TON_RS09760
uniprot id: B6YW39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

523850:TON RS10015
gene id: 523850:TON_RS10015
uniprot id: B6YW85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS02950
gene id: 523850:TON_RS02950
uniprot id: B6YUM1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523850:TON RS00545
gene id: 523850:TON_RS00545
uniprot id: B6YSQ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

523850:TON RS05655
gene id: 523850:TON_RS05655
uniprot id: B6YWY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

523850:TON RS03980
gene id: 523850:TON_RS03980
uniprot id: B6YVT9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS01460
gene id: 523850:TON_RS01460
uniprot id: B6YT76
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03495
gene id: 523850:TON_RS03495
uniprot id: B6YV88
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS01745
gene id: 523850:TON_RS01745
uniprot id: B6YTD3
names: Similarity
messages: Belongs to the arginase family.

523850:TON RS02600
gene id: 523850:TON_RS02600
uniprot id: B6YU46
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523850:TON RS08950
gene id: 523850:TON_RS08950
uniprot id: B6YV18
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523850:TON RS04840
gene id: 523850:TON_RS04840
uniprot id: B6YWH3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

523850:TON RS03640
gene id: 523850:TON_RS03640
uniprot id: B6YVB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

523850:TON RS08555
gene id: 523850:TON_RS08555
uniprot id: B6YUI1
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03675
gene id: 523850:TON_RS03675
uniprot id: B6YVC4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

523850:TON RS08070
gene id: 523850:TON_RS08070
uniprot id: B6YTX9
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07785
gene id: 523850:TON_RS07785
uniprot id: B6YTS3
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00720
gene id: 523850:TON_RS00720
uniprot id: B6YST5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523850:TON RS03685
gene id: 523850:TON_RS03685
uniprot id: B6YVC6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

523850:TON RS08405
gene id: 523850:TON_RS08405
uniprot id: B6YUF2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

523850:TON RS02030
gene id: 523850:TON_RS02030
uniprot id: B6YTI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

523850:TON RS00935
gene id: 523850:TON_RS00935
uniprot id: B6YSX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

523850:TON RS09480
gene id: 523850:TON_RS09480
uniprot id: B6YVM7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

523850:TON RS08095
gene id: 523850:TON_RS08095
uniprot id: B6YTY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS02890
gene id: 523850:TON_RS02890
uniprot id: B6YUK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

523850:TON RS08465
gene id: 523850:TON_RS08465
uniprot id: B6YUG4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS02575
gene id: 523850:TON_RS02575
uniprot id: B6YU41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS03855
gene id: 523850:TON_RS03855
uniprot id: B6YVF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

523850:TON RS08055
gene id: 523850:TON_RS08055
uniprot id: B6YTX6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS01585
gene id: 523850:TON_RS01585
uniprot id: B6YTA3
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

523850:TON RS07635
gene id: 523850:TON_RS07635
uniprot id: B6YTP6
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) (By similarity). Can also dephosphorylate, with lower activity, other related substrates including fructose-1-phosphate, fructose-6-phosphate, glucose-1-phosphate, glucose-6-phosphate, glycerol-2-phosphate, phosphoenolpyruvate, 5'-AMP, 6'-ADP and 7'-ATP (PubMed:21221938).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: FBPase activity is inhibited by Ca(2+), ATP, ADP and phosphoenolpyruvate.
messages: Homooctamer; dimer of tetramers.

523850:TON RS01650
gene id: 523850:TON_RS01650
uniprot id: B6YTB4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

523850:TON RS09955
gene id: 523850:TON_RS09955
uniprot id: B6YW76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523850:TON RS00820
gene id: 523850:TON_RS00820
uniprot id: B6YSV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

523850:TON RS06370
gene id: 523850:TON_RS06370
uniprot id: B6YXD4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523850:TON RS05260
gene id: 523850:TON_RS05260
uniprot id: B6YWQ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS02070
gene id: 523850:TON_RS02070
uniprot id: B6YTJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523850:TON RS04855
gene id: 523850:TON_RS04855
uniprot id: B6YWH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

523850:TON RS01945
gene id: 523850:TON_RS01945
uniprot id: B6YTG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

523850:TON RS05530
gene id: 523850:TON_RS05530
uniprot id: B6YWV7
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

523850:TON RS08325
gene id: 523850:TON_RS08325
uniprot id: B6YUD6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04545
gene id: 523850:TON_RS04545
uniprot id: B6YWB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

523850:TON RS04590
gene id: 523850:TON_RS04590
uniprot id: B6YWC2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

523850:TON RS02965
gene id: 523850:TON_RS02965
uniprot id: B6YUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523850:TON RS00350
gene id: 523850:TON_RS00350
uniprot id: B6YSL7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

523850:TON RS09140
gene id: 523850:TON_RS09140
uniprot id: B6YV57
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

523850:TON RS05020
gene id: 523850:TON_RS05020
uniprot id: B6YWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS00135
gene id: 523850:TON_RS00135
uniprot id: B6YSH9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523850:TON RS06570
gene id: 523850:TON_RS06570
uniprot id: B6YXH5
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

523850:TON RS07305
gene id: 523850:TON_RS07305
uniprot id: B6YXW1
names: Similarity
messages: Belongs to the UPF0047 family.

523850:TON RS03825
gene id: 523850:TON_RS03825
uniprot id: B6YVF2
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

523850:TON RS06555
gene id: 523850:TON_RS06555
uniprot id: B6YXH2
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

523850:TON RS02115
gene id: 523850:TON_RS02115
uniprot id: B6YTK3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

523850:TON RS09125
gene id: 523850:TON_RS09125
uniprot id: B6YV54
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

523850:TON RS09015
gene id: 523850:TON_RS09015
uniprot id: B6YV32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

523850:TON RS03650
gene id: 523850:TON_RS03650
uniprot id: B6YVB9
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

523850:TON RS03940
gene id: 523850:TON_RS03940
uniprot id: B6YVT1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523850:TON RS03140
gene id: 523850:TON_RS03140
uniprot id: B6YUQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

523850:TON RS08830
gene id: 523850:TON_RS08830
uniprot id: B6YUZ4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

523850:TON RS05415
gene id: 523850:TON_RS05415
uniprot id: B6YWT3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

523850:TON RS01410
gene id: 523850:TON_RS01410
uniprot id: B6YT66
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00715
gene id: 523850:TON_RS00715
uniprot id: B6YST4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS06545
gene id: 523850:TON_RS06545
uniprot id: B6YXG9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS04970
gene id: 523850:TON_RS04970
uniprot id: B6YWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523850:TON RS05515
gene id: 523850:TON_RS05515
uniprot id: B6YWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

523850:TON RS07805
gene id: 523850:TON_RS07805
uniprot id: B6YTS6
names: Subunit
messages: Homotetramer.

523850:TON RS00240
gene id: 523850:TON_RS00240
uniprot id: B6YSJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

523850:TON RS08835
gene id: 523850:TON_RS08835
uniprot id: B6YUZ5
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523850:TON RS04825
gene id: 523850:TON_RS04825
uniprot id: B6YWH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS00745
gene id: 523850:TON_RS00745
uniprot id: B6YST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523850:TON RS09630
gene id: 523850:TON_RS09630
uniprot id: B6YVQ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

523850:TON RS08435
gene id: 523850:TON_RS08435
uniprot id: B6YUF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

523850:TON RS06855
gene id: 523850:TON_RS06855
uniprot id: B6YXN1
names: Similarity
messages: Belongs to the AOR/FOR family.

523850:TON RS05610
gene id: 523850:TON_RS05610
uniprot id: B6YWX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

523850:TON RS06475
gene id: 523850:TON_RS06475
uniprot id: B6YXF5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

523850:TON RS06620
gene id: 523850:TON_RS06620
uniprot id: B6YXI6
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

523850:TON RS02940
gene id: 523850:TON_RS02940
uniprot id: B6YUL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS04835
gene id: 523850:TON_RS04835
uniprot id: B6YWH2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

523850:TON RS07440
gene id: 523850:TON_RS07440
uniprot id: B6YXY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

523850:TON RS00775
gene id: 523850:TON_RS00775
uniprot id: B6YSU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

523850:TON RS09110
gene id: 523850:TON_RS09110
uniprot id: B6YV51
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523850:TON RS09055
gene id: 523850:TON_RS09055
uniprot id: B6YV40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

523850:TON RS00955
gene id: 523850:TON_RS00955
uniprot id: B6YSY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523850:TON RS09725
gene id: 523850:TON_RS09725
uniprot id: B6YVS4
names: Similarity
messages: Belongs to the peptidase S8 family.

523850:TON RS07410
gene id: 523850:TON_RS07410
uniprot id: B6YXY1
names: Similarity
messages: Belongs to the peptidase U62 family.

523850:TON RS00075
gene id: 523850:TON_RS00075
uniprot id: B6YSG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS05250
gene id: 523850:TON_RS05250
uniprot id: B6YWQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS08990
gene id: 523850:TON_RS08990
uniprot id: B6YV27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523850:TON RS03485
gene id: 523850:TON_RS03485
uniprot id: B6YV86
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

523850:TON RS04740
gene id: 523850:TON_RS04740
uniprot id: B6YWF3
names: Similarity
messages: Belongs to the UPF0251 family.

523850:TON RS00415
gene id: 523850:TON_RS00415
uniprot id: B6YSN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

523850:TON RS05160
gene id: 523850:TON_RS05160
uniprot id: B6YWN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

523850:TON RS01545
gene id: 523850:TON_RS01545
uniprot id: B6YT95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523850:TON RS02625
gene id: 523850:TON_RS02625
uniprot id: B6YU51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

523850:TON RS01955
gene id: 523850:TON_RS01955
uniprot id: B6YTH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS05775
gene id: 523850:TON_RS05775
uniprot id: B6YX11
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS08815
gene id: 523850:TON_RS08815
uniprot id: B6YUZ1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

523850:TON RS01455
gene id: 523850:TON_RS01455
uniprot id: B6YT75
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00590
gene id: 523850:TON_RS00590
uniprot id: B6YSR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

523850:TON RS05915
gene id: 523850:TON_RS05915
uniprot id: B6YX42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

523850:TON RS08490
gene id: 523850:TON_RS08490
uniprot id: B6YUG9
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08040
gene id: 523850:TON_RS08040
uniprot id: B6YTX3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS10135
gene id: 523850:TON_RS10135
uniprot id: B6YTU6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00830
gene id: 523850:TON_RS00830
uniprot id: B6YSV6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00570
gene id: 523850:TON_RS00570
uniprot id: B6YSQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS04860
gene id: 523850:TON_RS04860
uniprot id: B6YWH8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

523850:TON RS07055
gene id: 523850:TON_RS07055
uniprot id: B6YXR5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523850:TON RS04035
gene id: 523850:TON_RS04035
uniprot id: B6YVV0
names: Similarity
messages: Belongs to the pyruvate kinase family.

523850:TON RS00335
gene id: 523850:TON_RS00335
uniprot id: B6YSL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

523850:TON RS09640
gene id: 523850:TON_RS09640
uniprot id: B6YVQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

523850:TON RS07325
gene id: 523850:TON_RS07325
uniprot id: B6YXW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

523850:TON RS04580
gene id: 523850:TON_RS04580
uniprot id: B6YWC0
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

523850:TON RS03340
gene id: 523850:TON_RS03340
uniprot id: B6YUU9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

523850:TON RS02135
gene id: 523850:TON_RS02135
uniprot id: B6YTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

523850:TON RS04085
gene id: 523850:TON_RS04085
uniprot id: B6YVW0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

523850:TON RS06150
gene id: 523850:TON_RS06150
uniprot id: B6YX89
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

523850:TON RS03085
gene id: 523850:TON_RS03085
uniprot id: B6YUP8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07615
gene id: 523850:TON_RS07615
uniprot id: B6YY21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

523850:TON RS02005
gene id: 523850:TON_RS02005
uniprot id: B6YTI1
names: Similarity
messages: Belongs to the peptidase S49 family.

523850:TON RS06250
gene id: 523850:TON_RS06250
uniprot id: B6YXA9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

523850:TON RS03035
gene id: 523850:TON_RS03035
uniprot id: B6YUN8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

523850:TON RS09120
gene id: 523850:TON_RS09120
uniprot id: B6YV53
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS00485
gene id: 523850:TON_RS00485
uniprot id: B6YSP4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

523850:TON RS01165
gene id: 523850:TON_RS01165
uniprot id: B6YT18
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

523850:TON RS01970
gene id: 523850:TON_RS01970
uniprot id: B6YTH4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

523850:TON RS03540
gene id: 523850:TON_RS03540
uniprot id: B6YV97
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

523850:TON RS07150
gene id: 523850:TON_RS07150
uniprot id: B6YXT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

523850:TON RS05525
gene id: 523850:TON_RS05525
uniprot id: B6YWV6
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

523850:TON RS05605
gene id: 523850:TON_RS05605
uniprot id: B6YWX3
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07895
gene id: 523850:TON_RS07895
uniprot id: B6YTU2
names: Similarity
messages: Belongs to the peptidase S9C family.

523850:TON RS04660
gene id: 523850:TON_RS04660
uniprot id: B6YWD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

523850:TON RS05585
gene id: 523850:TON_RS05585
uniprot id: B6YWW9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523850:TON RS09650
gene id: 523850:TON_RS09650
uniprot id: B6YVQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

523850:TON RS00445
gene id: 523850:TON_RS00445
uniprot id: B6YSN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523850:TON RS08695
gene id: 523850:TON_RS08695
uniprot id: B6YUW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523850:TON RS08115
gene id: 523850:TON_RS08115
uniprot id: B6YTY8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS05270
gene id: 523850:TON_RS05270
uniprot id: B6YWQ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523850:TON RS01200
gene id: 523850:TON_RS01200
uniprot id: B6YT25
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS06010
gene id: 523850:TON_RS06010
uniprot id: B6YX62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523850:TON RS03500
gene id: 523850:TON_RS03500
uniprot id: B6YV89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523850:TON RS00560
gene id: 523850:TON_RS00560
uniprot id: B6YSQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS08365
gene id: 523850:TON_RS08365
uniprot id: B6YUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

523850:TON RS06725
gene id: 523850:TON_RS06725
uniprot id: B6YXK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS08915
gene id: 523850:TON_RS08915
uniprot id: B6YV11
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523850:TON RS04770
gene id: 523850:TON_RS04770
uniprot id: B6YWF9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

523850:TON RS01180
gene id: 523850:TON_RS01180
uniprot id: B6YT21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

523850:TON RS00145
gene id: 523850:TON_RS00145
uniprot id: B6YSI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

523850:TON RS09735
gene id: 523850:TON_RS09735
uniprot id: B6YW34
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

523850:TON RS01110
gene id: 523850:TON_RS01110
uniprot id: B6YT11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

523850:TON RS08890
gene id: 523850:TON_RS08890
uniprot id: B6YV06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

523850:TON RS07520
gene id: 523850:TON_RS07520
uniprot id: B6YY02
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

523850:TON RS02265
gene id: 523850:TON_RS02265
uniprot id: B6YTN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

523850:TON RS08010
gene id: 523850:TON_RS08010
uniprot id: B6YTW7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS05925
gene id: 523850:TON_RS05925
uniprot id: B6YX44
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

523850:TON RS07220
gene id: 523850:TON_RS07220
uniprot id: B6YXU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

523850:TON RS02205
gene id: 523850:TON_RS02205
uniprot id: B6YTM1
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS01345
gene id: 523850:TON_RS01345
uniprot id: B6YT53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523850:TON RS08105
gene id: 523850:TON_RS08105
uniprot id: B6YTY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS03240
gene id: 523850:TON_RS03240
uniprot id: B6YUS8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523850:TON RS09580
gene id: 523850:TON_RS09580
uniprot id: B6YVP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

523850:TON RS09430
gene id: 523850:TON_RS09430
uniprot id: B6YVL8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08235
gene id: 523850:TON_RS08235
uniprot id: B6YUB8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

523850:TON RS04575
gene id: 523850:TON_RS04575
uniprot id: B6YWB9
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

523850:TON RS01150
gene id: 523850:TON_RS01150
uniprot id: B6YT15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523850:TON RS07100
gene id: 523850:TON_RS07100
uniprot id: B6YXS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS02525
gene id: 523850:TON_RS02525
uniprot id: B6YU31
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

523850:TON RS06400
gene id: 523850:TON_RS06400
uniprot id: B6YXD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

523850:TON RS01160
gene id: 523850:TON_RS01160
uniprot id: B6YT17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

523850:TON RS03360
gene id: 523850:TON_RS03360
uniprot id: B6YUV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

523850:TON RS03670
gene id: 523850:TON_RS03670
uniprot id: B6YVC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

523850:TON RS05450
gene id: 523850:TON_RS05450
uniprot id: B6YWU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523850:TON RS06140
gene id: 523850:TON_RS06140
uniprot id: B6YX87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

523850:TON RS00190
gene id: 523850:TON_RS00190
uniprot id: B6YSI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS09600
gene id: 523850:TON_RS09600
uniprot id: B6YVP8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

523850:TON RS04890
gene id: 523850:TON_RS04890
uniprot id: B6YWI4
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09890
gene id: 523850:TON_RS09890
uniprot id: B6YW63
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

523850:TON RS00930
gene id: 523850:TON_RS00930
uniprot id: B6YSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

523850:TON RS08760
gene id: 523850:TON_RS08760
uniprot id: B6YUX8
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

523850:TON RS02555
gene id: 523850:TON_RS02555
uniprot id: B6YU37
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08885
gene id: 523850:TON_RS08885
uniprot id: B6YV05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

523850:TON RS06760
gene id: 523850:TON_RS06760
uniprot id: B6YXL4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

523850:TON RS00805
gene id: 523850:TON_RS00805
uniprot id: B6YSV1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

523850:TON RS01670
gene id: 523850:TON_RS01670
uniprot id: B6YTB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

523850:TON RS02900
gene id: 523850:TON_RS02900
uniprot id: B6YUL1
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

523850:TON RS02165
gene id: 523850:TON_RS02165
uniprot id: B6YTL3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523850:TON RS05905
gene id: 523850:TON_RS05905
uniprot id: B6YX40
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

523850:TON RS06685
gene id: 523850:TON_RS06685
uniprot id: B6YXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

523850:TON RS08625
gene id: 523850:TON_RS08625
uniprot id: B6YUJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

523850:TON RS04865
gene id: 523850:TON_RS04865
uniprot id: B6YWH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

523850:TON RS02015
gene id: 523850:TON_RS02015
uniprot id: B6YTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523850:TON RS06950
gene id: 523850:TON_RS06950
uniprot id: B6YXP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

523850:TON RS05615
gene id: 523850:TON_RS05615
uniprot id: B6YWX5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523850:TON RS02350
gene id: 523850:TON_RS02350
uniprot id: B6YTZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523850:TON RS08075
gene id: 523850:TON_RS08075
uniprot id: B6YTY0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523850:TON RS05645
gene id: 523850:TON_RS05645
uniprot id: B6YWY1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

523850:TON RS03880
gene id: 523850:TON_RS03880
uniprot id: B6YVG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523850:TON RS03285
gene id: 523850:TON_RS03285
uniprot id: B6YUT8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

523850:TON RS02815
gene id: 523850:TON_RS02815
uniprot id: B6YU88
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523850:TON RS00380
gene id: 523850:TON_RS00380
uniprot id: B6YSM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

523850:TON RS06530
gene id: 523850:TON_RS06530
uniprot id: B6YXG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523850:TON RS00430
gene id: 523850:TON_RS00430
uniprot id: B6YSN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

523850:TON RS07170
gene id: 523850:TON_RS07170
uniprot id: B6YXT4
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

523850:TON RS00790
gene id: 523850:TON_RS00790
uniprot id: B6YSU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

523850:TON RS02680
gene id: 523850:TON_RS02680
uniprot id: B6YU62
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

523850:TON RS00520
gene id: 523850:TON_RS00520
uniprot id: B6YSQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

523850:TON RS01025
gene id: 523850:TON_RS01025
uniprot id: B6YSZ4
names: Similarity
messages: Belongs to the thymidylate kinase family.

523850:TON RS08050
gene id: 523850:TON_RS08050
uniprot id: B6YTX5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS01600
gene id: 523850:TON_RS01600
uniprot id: B6YTA6
names: Similarity
messages: Belongs to the peptidase S8 family.

523850:TON RS09695
gene id: 523850:TON_RS09695
uniprot id: B6YVR8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS09420
gene id: 523850:TON_RS09420
uniprot id: B6YVL6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

523850:TON RS06795
gene id: 523850:TON_RS06795
uniprot id: B6YXM1
names: Similarity
messages: Belongs to the UPF0200 family.

523850:TON RS05080
gene id: 523850:TON_RS05080
uniprot id: B6YWM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

523850:TON RS05485
gene id: 523850:TON_RS05485
uniprot id: B6YWU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

523850:TON RS00895
gene id: 523850:TON_RS00895
uniprot id: B6YSW7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

523850:TON RS08940
gene id: 523850:TON_RS08940
uniprot id: B6YV16
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523850:TON RS02510
gene id: 523850:TON_RS02510
uniprot id: B6YU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

523850:TON RS04255
gene id: 523850:TON_RS04255
uniprot id: B6YVZ4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

523850:TON RS08980
gene id: 523850:TON_RS08980
uniprot id: B6YV25
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

523850:TON RS00220
gene id: 523850:TON_RS00220
uniprot id: B6YSJ1
names: Subcellular Location Annotation
messages: Nucleus

523850:TON RS00280
gene id: 523850:TON_RS00280
uniprot id: B6YSK3
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

523850:TON RS00090
gene id: 523850:TON_RS00090
uniprot id: B6YSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523850:TON RS08110
gene id: 523850:TON_RS08110
uniprot id: B6YTY7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS04130
gene id: 523850:TON_RS04130
uniprot id: B6YVW9
names: Similarity
messages: Belongs to the peptidase U62 family.

523850:TON RS06745
gene id: 523850:TON_RS06745
uniprot id: B6YXL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

523850:TON RS05570
gene id: 523850:TON_RS05570
uniprot id: B6YWW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

523850:TON RS08380
gene id: 523850:TON_RS08380
uniprot id: B6YUE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523850:TON RS01910
gene id: 523850:TON_RS01910
uniprot id: B6YTG2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523850:TON RS06000
gene id: 523850:TON_RS06000
uniprot id: B6YX60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523850:TON RS07275
gene id: 523850:TON_RS07275
uniprot id: B6YXV5
names: Similarity
messages: Belongs to the threonine synthase family.

523850:TON RS04380
gene id: 523850:TON_RS04380
uniprot id: B6YW19
names: Similarity
messages: Belongs to the TBP family.

523850:TON RS09940
gene id: 523850:TON_RS09940
uniprot id: B6YW73
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

523850:TON RS04230
gene id: 523850:TON_RS04230
uniprot id: B6YVY9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

523850:TON RS06630
gene id: 523850:TON_RS06630
uniprot id: B6YXI8
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523850:TON RS03060
gene id: 523850:TON_RS03060
uniprot id: B6YUP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523850:TON RS00705
gene id: 523850:TON_RS00705
uniprot id: B6YST2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

523850:TON RS04515
gene id: 523850:TON_RS04515
uniprot id: B6YWA7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

523850:TON RS02080
gene id: 523850:TON_RS02080
uniprot id: B6YTJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

523850:TON RS08910
gene id: 523850:TON_RS08910
uniprot id: B6YV10
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS03335
gene id: 523850:TON_RS03335
uniprot id: B6YUU8
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07505
gene id: 523850:TON_RS07505
uniprot id: B6YXZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

523850:TON RS09615
gene id: 523850:TON_RS09615
uniprot id: B6YVQ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

523850:TON RS05500
gene id: 523850:TON_RS05500
uniprot id: B6YWV0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

523850:TON RS02955
gene id: 523850:TON_RS02955
uniprot id: B6YUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523850:TON RS06005
gene id: 523850:TON_RS06005
uniprot id: B6YX61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523850:TON RS02930
gene id: 523850:TON_RS02930
uniprot id: B6YUL7
names: Similarity
messages: Belongs to the NodU/CmcH family.

523850:TON RS04530
gene id: 523850:TON_RS04530
uniprot id: B6YWB0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

523850:TON RS00395
gene id: 523850:TON_RS00395
uniprot id: B6YSM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

523850:TON RS08790
gene id: 523850:TON_RS08790
uniprot id: B6YUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523850:TON RS00330
gene id: 523850:TON_RS00330
uniprot id: B6YSL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

523850:TON RS02655
gene id: 523850:TON_RS02655
uniprot id: B6YU58
names: Similarity
messages: Belongs to the UPF0107 family.

523850:TON RS07990
gene id: 523850:TON_RS07990
uniprot id: B6YTW3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523850:TON RS04195
gene id: 523850:TON_RS04195
uniprot id: B6YVY2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

523850:TON RS03210
gene id: 523850:TON_RS03210
uniprot id: B6YUS2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523850:TON RS04210
gene id: 523850:TON_RS04210
uniprot id: B6YVY5
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02285
gene id: 523850:TON_RS02285
uniprot id: B6YTN7
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS06875
gene id: 523850:TON_RS06875
uniprot id: B6YXN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

523850:TON RS06805
gene id: 523850:TON_RS06805
uniprot id: B6YXM3
names: Similarity
messages: Belongs to the UPF0201 family.

523850:TON RS06680
gene id: 523850:TON_RS06680
uniprot id: B6YXJ8
names: Subcellular Location Annotation
messages: Cell membrane

523850:TON RS05630
gene id: 523850:TON_RS05630
uniprot id: B6YWX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

523850:TON RS07870
gene id: 523850:TON_RS07870
uniprot id: B6YTT7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

523850:TON RS06965
gene id: 523850:TON_RS06965
uniprot id: B6YXQ2
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

523850:TON RS02565
gene id: 523850:TON_RS02565
uniprot id: B6YU39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS03555
gene id: 523850:TON_RS03555
uniprot id: B6YVA0
names: Similarity
messages: Belongs to the MoaB/Mog family.

523850:TON RS08905
gene id: 523850:TON_RS08905
uniprot id: B6YV09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

523850:TON RS07255
gene id: 523850:TON_RS07255
uniprot id: B6YXV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523850:TON RS00140
gene id: 523850:TON_RS00140
uniprot id: B6YSI0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

523850:TON RS07235
gene id: 523850:TON_RS07235
uniprot id: B6YXU7
names: Similarity
messages: Belongs to the HerA family.

523850:TON RS00940
gene id: 523850:TON_RS00940
uniprot id: B6YSX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523850:TON RS00555
gene id: 523850:TON_RS00555
uniprot id: B6YSQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

523850:TON RS09715
gene id: 523850:TON_RS09715
uniprot id: B6YVS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

523850:TON RS07465
gene id: 523850:TON_RS07465
uniprot id: B6YXZ1
names: Similarity
messages: Belongs to the UPF0111 family.

523850:TON RS01750
gene id: 523850:TON_RS01750
uniprot id: B6YTD4
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

523850:TON RS05790
gene id: 523850:TON_RS05790
uniprot id: B6YX14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

523850:TON RS02230
gene id: 523850:TON_RS02230
uniprot id: B6YTM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

523850:TON RS07175
gene id: 523850:TON_RS07175
uniprot id: B6YXT5
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

523850:TON RS05410
gene id: 523850:TON_RS05410
uniprot id: B6YWT2
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08500
gene id: 523850:TON_RS08500
uniprot id: B6YUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523850:TON RS01330
gene id: 523850:TON_RS01330
uniprot id: B6YT50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

523850:TON RS03355
gene id: 523850:TON_RS03355
uniprot id: B6YUV2
names: Similarity
messages: Belongs to the peptidase M24B family.

523850:TON RS08080
gene id: 523850:TON_RS08080
uniprot id: B6YTY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523850:TON RS04100
gene id: 523850:TON_RS04100
uniprot id: B6YVW3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523850:TON RS03315
gene id: 523850:TON_RS03315
uniprot id: B6YUU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

523850:TON RS04375
gene id: 523850:TON_RS04375
uniprot id: B6YW18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

523850:TON RS07750
gene id: 523850:TON_RS07750
uniprot id: B6YTR6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS02105
gene id: 523850:TON_RS02105
uniprot id: B6YTK1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

523850:TON RS07600
gene id: 523850:TON_RS07600
uniprot id: B6YY18
names: Similarity
messages: Belongs to the CutA family.

523850:TON RS08400
gene id: 523850:TON_RS08400
uniprot id: B6YUF1
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS08385
gene id: 523850:TON_RS08385
uniprot id: B6YUE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523850:TON RS02650
gene id: 523850:TON_RS02650
uniprot id: B6YU57
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS07320
gene id: 523850:TON_RS07320
uniprot id: B6YXW4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

523850:TON RS05265
gene id: 523850:TON_RS05265
uniprot id: B6YWQ6
names: Subcellular Location Annotation
messages: Membrane

523850:TON RS01310
gene id: 523850:TON_RS01310
uniprot id: B6YT45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

523850:TON RS05920
gene id: 523850:TON_RS05920
uniprot id: B6YX43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

523850:TON RS05420
gene id: 523850:TON_RS05420
uniprot id: B6YWT4
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.