523844:MSTHT RS07540
gene id: 523844:MSTHT_RS07540
uniprot id: A0A0E3N986
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523844:MSTHT RS07900
gene id: 523844:MSTHT_RS07900
uniprot id: A0A0E3NCD0
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS05890
gene id: 523844:MSTHT_RS05890
uniprot id: A0A0E3NEA4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

523844:MSTHT RS11195
gene id: 523844:MSTHT_RS11195
uniprot id: A0A0E3H9C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

523844:MSTHT RS01135
gene id: 523844:MSTHT_RS01135
uniprot id: A0A0E3KNT0
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06005
gene id: 523844:MSTHT_RS06005
uniprot id: A0A0E3N8V8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

523844:MSTHT RS03970
gene id: 523844:MSTHT_RS03970
uniprot id: A0A0E3NAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

523844:MSTHT RS10705
gene id: 523844:MSTHT_RS10705
uniprot id: A0A0E3KQ38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS00790
gene id: 523844:MSTHT_RS00790
uniprot id: A0A0E3KNS0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

523844:MSTHT RS11245
gene id: 523844:MSTHT_RS11245
uniprot id: A0A0E3H9C8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523844:MSTHT RS00405
gene id: 523844:MSTHT_RS00405
uniprot id: A0A0E3KNR0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

523844:MSTHT RS10125
gene id: 523844:MSTHT_RS10125
uniprot id: A0A0E3KZ55
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523844:MSTHT RS02790
gene id: 523844:MSTHT_RS02790
uniprot id: A0A0E3N7Q8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

523844:MSTHT RS00150
gene id: 523844:MSTHT_RS00150
uniprot id: A0A0E3KXV2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS03150
gene id: 523844:MSTHT_RS03150
uniprot id: A0A0E3KP09
names: Similarity
messages: Belongs to the peptidase C56 family.

523844:MSTHT RS11040
gene id: 523844:MSTHT_RS11040
uniprot id: A0A0E3H9C0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS05705
gene id: 523844:MSTHT_RS05705
uniprot id: A0A0E3NBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS00990
gene id: 523844:MSTHT_RS00990
uniprot id: A0A0E3H888
names: Similarity
messages: Belongs to the UPF0758 family.

523844:MSTHT RS07000
gene id: 523844:MSTHT_RS07000
uniprot id: A0A0E3H8W9
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

523844:MSTHT RS11240
gene id: 523844:MSTHT_RS11240
uniprot id: A0A0E3KZ91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS11420
gene id: 523844:MSTHT_RS11420
uniprot id: A0A0E3NCT8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS03280
gene id: 523844:MSTHT_RS03280
uniprot id: A0A0E3KP14
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

523844:MSTHT RS10320
gene id: 523844:MSTHT_RS10320
uniprot id: A0A0E3NFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

523844:MSTHT RS04100
gene id: 523844:MSTHT_RS04100
uniprot id: A0A0E3H8K8
names: Similarity
messages: Belongs to the TlyA family.

523844:MSTHT RS01725
gene id: 523844:MSTHT_RS01725
uniprot id: A0A0E3ND35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523844:MSTHT RS05570
gene id: 523844:MSTHT_RS05570
uniprot id: A0A0E3NCX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

523844:MSTHT RS00530
gene id: 523844:MSTHT_RS00530
uniprot id: A0A0E3NAK2
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

523844:MSTHT RS10150
gene id: 523844:MSTHT_RS10150
uniprot id: A0A0E3NFD3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

523844:MSTHT RS00090
gene id: 523844:MSTHT_RS00090
uniprot id: A0A0E3KNQ0
names: Similarity
messages: Belongs to the MtrH family.

523844:MSTHT RS01930
gene id: 523844:MSTHT_RS01930
uniprot id: A0A0E3N7H9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS07355
gene id: 523844:MSTHT_RS07355
uniprot id: A0A0E3KPP8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

523844:MSTHT RS01170
gene id: 523844:MSTHT_RS01170
uniprot id: A0A0E3N9Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

523844:MSTHT RS07340
gene id: 523844:MSTHT_RS07340
uniprot id: A0A0E3NDA6
names: Similarity
messages: Belongs to the thioesterase PaaI family.

523844:MSTHT RS04925
gene id: 523844:MSTHT_RS04925
uniprot id: A0A0E3KPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

523844:MSTHT RS05310
gene id: 523844:MSTHT_RS05310
uniprot id: A0A0E3KYM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

523844:MSTHT RS10045
gene id: 523844:MSTHT_RS10045
uniprot id: A0A0E3KQ12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS01255
gene id: 523844:MSTHT_RS01255
uniprot id: A0A0E3NCZ0
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

523844:MSTHT RS08395
gene id: 523844:MSTHT_RS08395
uniprot id: A0A0E3NEY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

523844:MSTHT RS11485
gene id: 523844:MSTHT_RS11485
uniprot id: A0A0E3H9D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

523844:MSTHT RS03395
gene id: 523844:MSTHT_RS03395
uniprot id: A0A0E3NDK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

523844:MSTHT RS10335
gene id: 523844:MSTHT_RS10335
uniprot id: A0A0E3NE08
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

523844:MSTHT RS09380
gene id: 523844:MSTHT_RS09380
uniprot id: A0A0E3N9P6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS10470
gene id: 523844:MSTHT_RS10470
uniprot id: A0A0E3ND05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523844:MSTHT RS08780
gene id: 523844:MSTHT_RS08780
uniprot id: A0A0E3H938
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

523844:MSTHT RS06505
gene id: 523844:MSTHT_RS06505
uniprot id: A0A0E3KPL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

523844:MSTHT RS05680
gene id: 523844:MSTHT_RS05680
uniprot id: A0A0E3KYQ2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523844:MSTHT RS11405
gene id: 523844:MSTHT_RS11405
uniprot id: A0A0E3NEA3
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

523844:MSTHT RS11100
gene id: 523844:MSTHT_RS11100
uniprot id: A0A0E3NA78
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

523844:MSTHT RS09360
gene id: 523844:MSTHT_RS09360
uniprot id: A0A0E3NC91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523844:MSTHT RS13200
gene id: 523844:MSTHT_RS13200
uniprot id: A0A0E3H9K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

523844:MSTHT RS12510
gene id: 523844:MSTHT_RS12510
uniprot id: A0A0E3KQB8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS01430
gene id: 523844:MSTHT_RS01430
uniprot id: A0A0E3NBV4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523844:MSTHT RS08755
gene id: 523844:MSTHT_RS08755
uniprot id: A0A0E3H937
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

523844:MSTHT RS10535
gene id: 523844:MSTHT_RS10535
uniprot id: A0A0E3H9A2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

523844:MSTHT RS05620
gene id: 523844:MSTHT_RS05620
uniprot id: A0A0E3H8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523844:MSTHT RS11555
gene id: 523844:MSTHT_RS11555
uniprot id: A0A0E3NAB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

523844:MSTHT RS01210
gene id: 523844:MSTHT_RS01210
uniprot id: A0A0E3NBU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

523844:MSTHT RS06310
gene id: 523844:MSTHT_RS06310
uniprot id: A0A0E3H8U3
names: Similarity
messages: Belongs to the NAD synthetase family.

523844:MSTHT RS12830
gene id: 523844:MSTHT_RS12830
uniprot id: A0A0E3H9I7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS05760
gene id: 523844:MSTHT_RS05760
uniprot id: A0A0E3NBU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

523844:MSTHT RS08655
gene id: 523844:MSTHT_RS08655
uniprot id: A0A0E3H933
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523844:MSTHT RS03275
gene id: 523844:MSTHT_RS03275
uniprot id: A0A0E3H8H7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

523844:MSTHT RS02615
gene id: 523844:MSTHT_RS02615
uniprot id: A0A0E3N7P5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS12690
gene id: 523844:MSTHT_RS12690
uniprot id: A0A0E3NFZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

523844:MSTHT RS05290
gene id: 523844:MSTHT_RS05290
uniprot id: A0A0E3KPE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523844:MSTHT RS04715
gene id: 523844:MSTHT_RS04715
uniprot id: A0A0E3KP99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523844:MSTHT RS10110
gene id: 523844:MSTHT_RS10110
uniprot id: A0A0E3H986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

523844:MSTHT RS01240
gene id: 523844:MSTHT_RS01240
uniprot id: A0A0E3N7D6
names: Function
messages: Part of a potassium transport system.

523844:MSTHT RS06640
gene id: 523844:MSTHT_RS06640
uniprot id: A0A0E3KYT5
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS11110
gene id: 523844:MSTHT_RS11110
uniprot id: A0A0E3H9C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

523844:MSTHT RS04615
gene id: 523844:MSTHT_RS04615
uniprot id: A0A0E3N8H4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

523844:MSTHT RS07920
gene id: 523844:MSTHT_RS07920
uniprot id: A0A0E3NEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

523844:MSTHT RS05910
gene id: 523844:MSTHT_RS05910
uniprot id: A0A0E3NB83
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

523844:MSTHT RS05640
gene id: 523844:MSTHT_RS05640
uniprot id: A0A0E3KYQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

523844:MSTHT RS06040
gene id: 523844:MSTHT_RS06040
uniprot id: A0A0E3NBW7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS08605
gene id: 523844:MSTHT_RS08605
uniprot id: A0A0E3H931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

523844:MSTHT RS12210
gene id: 523844:MSTHT_RS12210
uniprot id: A0A0E3NCZ9
names: Similarity
messages: Belongs to the DEAD box helicase family.

523844:MSTHT RS01220
gene id: 523844:MSTHT_RS01220
uniprot id: A0A0E3N9Z2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

523844:MSTHT RS03715
gene id: 523844:MSTHT_RS03715
uniprot id: A0A0E3KP32
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS13485
gene id: 523844:MSTHT_RS13485
uniprot id: A0A0E3NAX3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

523844:MSTHT RS10695
gene id: 523844:MSTHT_RS10695
uniprot id: A0A0E3H9A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS03985
gene id: 523844:MSTHT_RS03985
uniprot id: A0A0E3N813
names: Similarity
messages: Belongs to the ATPase gamma chain family.

523844:MSTHT RS05780
gene id: 523844:MSTHT_RS05780
uniprot id: A0A0E3NE94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

523844:MSTHT RS02170
gene id: 523844:MSTHT_RS02170
uniprot id: A0A0E3NA86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523844:MSTHT RS01230
gene id: 523844:MSTHT_RS01230
uniprot id: A0A0E3KNT3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

523844:MSTHT RS04810
gene id: 523844:MSTHT_RS04810
uniprot id: A0A0E3KYJ3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

523844:MSTHT RS05135
gene id: 523844:MSTHT_RS05135
uniprot id: A0A0E3KYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

523844:MSTHT RS00620
gene id: 523844:MSTHT_RS00620
uniprot id: A0A0E3NCU2
names: Similarity
messages: Belongs to the GARS family.

523844:MSTHT RS02475
gene id: 523844:MSTHT_RS02475
uniprot id: A0A0E3NAB2
names: Similarity
messages: Belongs to the AHA1 family.

523844:MSTHT RS07600
gene id: 523844:MSTHT_RS07600
uniprot id: A0A0E3NEQ7
names: Similarity
messages: Belongs to the UPF0292 family.

523844:MSTHT RS04820
gene id: 523844:MSTHT_RS04820
uniprot id: A0A0E3KPB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS03135
gene id: 523844:MSTHT_RS03135
uniprot id: P40881
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-class carbonic anhydrase family.
messages: Binds 1 Zn(2+) per subunit, at the subunit interface.
messages: Homotrimer.
messages: Reversible hydration of carbon dioxide. Important for growth on acetate (PubMed:8041719). As a probably extracellular enzyme, it may support a H(+)/CH(3)COO(-) symport mechanism and/or conversion of CO(2) to HCO(3)(-), removing excess CO(2) produced by growth on acetate (Probable).
messages: Secreted

523844:MSTHT RS11220
gene id: 523844:MSTHT_RS11220
uniprot id: A0A0E3H9C7
names: Similarity
messages: Belongs to the MEMO1 family.

523844:MSTHT RS01560
gene id: 523844:MSTHT_RS01560
uniprot id: A0A0E3H8B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

523844:MSTHT RS09885
gene id: 523844:MSTHT_RS09885
uniprot id: A0A0E3KZ45
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

523844:MSTHT RS09700
gene id: 523844:MSTHT_RS09700
uniprot id: A0A0E3H971
names: Similarity
messages: Belongs to the DtxR/MntR family.

523844:MSTHT RS05325
gene id: 523844:MSTHT_RS05325
uniprot id: A0A0E3NCU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

523844:MSTHT RS06335
gene id: 523844:MSTHT_RS06335
uniprot id: A0A0E3H8U4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523844:MSTHT RS06070
gene id: 523844:MSTHT_RS06070
uniprot id: A0A0E3ND12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS07915
gene id: 523844:MSTHT_RS07915
uniprot id: A0A0E3KYX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

523844:MSTHT RS05565
gene id: 523844:MSTHT_RS05565
uniprot id: A0A0E3H8R5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

523844:MSTHT RS05340
gene id: 523844:MSTHT_RS05340
uniprot id: A0A0E3KYM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523844:MSTHT RS10900
gene id: 523844:MSTHT_RS10900
uniprot id: A0A0E3KZ80
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

523844:MSTHT RS00690
gene id: 523844:MSTHT_RS00690
uniprot id: A0A0E3KXW9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

523844:MSTHT RS08275
gene id: 523844:MSTHT_RS08275
uniprot id: A0A0E3KPU0
names: Similarity
messages: Belongs to the HdrB family.

523844:MSTHT RS07385
gene id: 523844:MSTHT_RS07385
uniprot id: A0A0E3KPQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

523844:MSTHT RS02955
gene id: 523844:MSTHT_RS02955
uniprot id: A0A0E3KY78
names: Similarity
messages: Belongs to the class-I fumarase family.

523844:MSTHT RS12060
gene id: 523844:MSTHT_RS12060
uniprot id: A0A0E3NAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

523844:MSTHT RS03205
gene id: 523844:MSTHT_RS03205
uniprot id: A0A0E3NB54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523844:MSTHT RS08770
gene id: 523844:MSTHT_RS08770
uniprot id: A0A0E3NF08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

523844:MSTHT RS12070
gene id: 523844:MSTHT_RS12070
uniprot id: A0A0E3NFT8
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523844:MSTHT RS12560
gene id: 523844:MSTHT_RS12560
uniprot id: A0A0E3ND28
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

523844:MSTHT RS08660
gene id: 523844:MSTHT_RS08660
uniprot id: A0A0E3N9I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

523844:MSTHT RS11330
gene id: 523844:MSTHT_RS11330
uniprot id: A0A0E3H9D1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS13085
gene id: 523844:MSTHT_RS13085
uniprot id: A0A0E3KQE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS10725
gene id: 523844:MSTHT_RS10725
uniprot id: A0A0E3KZ74
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

523844:MSTHT RS05230
gene id: 523844:MSTHT_RS05230
uniprot id: A0A0E3KYL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

523844:MSTHT RS09710
gene id: 523844:MSTHT_RS09710
uniprot id: A0A0E3NDT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS03560
gene id: 523844:MSTHT_RS03560
uniprot id: A0A0E3N7X7
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

523844:MSTHT RS03330
gene id: 523844:MSTHT_RS03330
uniprot id: A0A0E3KYA1
names: Similarity
messages: Belongs to the PspA/IM30 family.

523844:MSTHT RS11095
gene id: 523844:MSTHT_RS11095
uniprot id: A0A0E3ND58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

523844:MSTHT RS11235
gene id: 523844:MSTHT_RS11235
uniprot id: A0A0E3NE88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS07790
gene id: 523844:MSTHT_RS07790
uniprot id: A0A0E3KYX5
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

523844:MSTHT RS01525
gene id: 523844:MSTHT_RS01525
uniprot id: A0A0E3H8A9
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

523844:MSTHT RS07935
gene id: 523844:MSTHT_RS07935
uniprot id: A0A0E3H905
names: Subcellular Location Annotation
messages: Cell membrane

523844:MSTHT RS03295
gene id: 523844:MSTHT_RS03295
uniprot id: A0A0E3KY99
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS12440
gene id: 523844:MSTHT_RS12440
uniprot id: A0A0E3ND19
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

523844:MSTHT RS05300
gene id: 523844:MSTHT_RS05300
uniprot id: A0A0E3N8Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523844:MSTHT RS11895
gene id: 523844:MSTHT_RS11895
uniprot id: A0A0E3NFS5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrE family.
messages: Binds 2 heme b (iron(II)-protoporphyrin IX) groups per subunit.
messages: Cell membrane
messages: Methanophenazine seems to mediate electron transfer from F(420)H(2) dehydrogenase to the dihydromethanophenazine:CoB--CoM heterodisulfide reductase.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane (PubMed:9654152, PubMed:9665708, PubMed:11034998). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB (PubMed:11034998).
messages: The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE.

523844:MSTHT RS11595
gene id: 523844:MSTHT_RS11595
uniprot id: A0A0E3KQ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

523844:MSTHT RS08390
gene id: 523844:MSTHT_RS08390
uniprot id: A0A0E3H923
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523844:MSTHT RS12550
gene id: 523844:MSTHT_RS12550
uniprot id: A0A0E3KQC0
names: Subcellular Location Annotation
messages: Cytoplasm

523844:MSTHT RS02465
gene id: 523844:MSTHT_RS02465
uniprot id: A0A0E3NC31
names: Similarity
messages: Belongs to the peptidase S8 family.

523844:MSTHT RS12435
gene id: 523844:MSTHT_RS12435
uniprot id: A0A0E3KZD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

523844:MSTHT RS07785
gene id: 523844:MSTHT_RS07785
uniprot id: A0A0E3H8Z9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

523844:MSTHT RS09625
gene id: 523844:MSTHT_RS09625
uniprot id: A0A0E3H968
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523844:MSTHT RS07145
gene id: 523844:MSTHT_RS07145
uniprot id: A0A0E3NC72
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523844:MSTHT RS10030
gene id: 523844:MSTHT_RS10030
uniprot id: A0A0E3KZ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

523844:MSTHT RS01900
gene id: 523844:MSTHT_RS01900
uniprot id: A0A0E3NBY2
names: Similarity
messages: Belongs to the AOR/FOR family.

523844:MSTHT RS06045
gene id: 523844:MSTHT_RS06045
uniprot id: A0A0E3KYR4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

523844:MSTHT RS07125
gene id: 523844:MSTHT_RS07125
uniprot id: A0A0E3ND89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523844:MSTHT RS02025
gene id: 523844:MSTHT_RS02025
uniprot id: A0A0E3NAU1
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

523844:MSTHT RS08160
gene id: 523844:MSTHT_RS08160
uniprot id: A0A0E3N9E5
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS07290
gene id: 523844:MSTHT_RS07290
uniprot id: A0A0E3NDA1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06010
gene id: 523844:MSTHT_RS06010
uniprot id: A0A0E3NEB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

523844:MSTHT RS07585
gene id: 523844:MSTHT_RS07585
uniprot id: A0A0E3NCA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS08715
gene id: 523844:MSTHT_RS08715
uniprot id: A0A0E3KZ07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

523844:MSTHT RS07860
gene id: 523844:MSTHT_RS07860
uniprot id: A0A0E3H902
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

523844:MSTHT RS09375
gene id: 523844:MSTHT_RS09375
uniprot id: A0A0E3H960
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

523844:MSTHT RS06095
gene id: 523844:MSTHT_RS06095
uniprot id: A0A0E3NBX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

523844:MSTHT RS07025
gene id: 523844:MSTHT_RS07025
uniprot id: A0A0E3H8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523844:MSTHT RS01730
gene id: 523844:MSTHT_RS01730
uniprot id: A0A0E3H8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523844:MSTHT RS00770
gene id: 523844:MSTHT_RS00770
uniprot id: A0A0E3NBS2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS12635
gene id: 523844:MSTHT_RS12635
uniprot id: A0A0E3KZD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

523844:MSTHT RS03995
gene id: 523844:MSTHT_RS03995
uniprot id: A0A0E3KYE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

523844:MSTHT RS02845
gene id: 523844:MSTHT_RS02845
uniprot id: A0A0E3NDE5
names: Subcellular Location Annotation
messages: Cell membrane

523844:MSTHT RS08735
gene id: 523844:MSTHT_RS08735
uniprot id: A0A0E3NDK9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523844:MSTHT RS10905
gene id: 523844:MSTHT_RS10905
uniprot id: A0A0E3NCP8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

523844:MSTHT RS08115
gene id: 523844:MSTHT_RS08115
uniprot id: A0A0E3NEW2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

523844:MSTHT RS10505
gene id: 523844:MSTHT_RS10505
uniprot id: A0A0E3KQ31
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

523844:MSTHT RS06085
gene id: 523844:MSTHT_RS06085
uniprot id: A0A0E3NB99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

523844:MSTHT RS06415
gene id: 523844:MSTHT_RS06415
uniprot id: A0A0E3KPK9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS08720
gene id: 523844:MSTHT_RS08720
uniprot id: A0A0E3NF05
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

523844:MSTHT RS05480
gene id: 523844:MSTHT_RS05480
uniprot id: A0A0E3NCV8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

523844:MSTHT RS09760
gene id: 523844:MSTHT_RS09760
uniprot id: A0A0E3KPZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523844:MSTHT RS07970
gene id: 523844:MSTHT_RS07970
uniprot id: A0A0E3NDE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

523844:MSTHT RS06055
gene id: 523844:MSTHT_RS06055
uniprot id: A0A0E3N8W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS08155
gene id: 523844:MSTHT_RS08155
uniprot id: A0A0E3KYY8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS05685
gene id: 523844:MSTHT_RS05685
uniprot id: A0A0E3NCY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

523844:MSTHT RS11020
gene id: 523844:MSTHT_RS11020
uniprot id: A0A0E3H9B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

523844:MSTHT RS11180
gene id: 523844:MSTHT_RS11180
uniprot id: A0A0E3NE83
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

523844:MSTHT RS09295
gene id: 523844:MSTHT_RS09295
uniprot id: A0A0E3KPY0
names: Similarity
messages: Belongs to the FwdC/FmdC family.

523844:MSTHT RS10775
gene id: 523844:MSTHT_RS10775
uniprot id: A0A0E3NE44
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

523844:MSTHT RS00495
gene id: 523844:MSTHT_RS00495
uniprot id: A0A0E3NCT4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.

523844:MSTHT RS12355
gene id: 523844:MSTHT_RS12355
uniprot id: A0A0E3KQA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

523844:MSTHT RS12640
gene id: 523844:MSTHT_RS12640
uniprot id: A0A0E3NFY9
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

523844:MSTHT RS01710
gene id: 523844:MSTHT_RS01710
uniprot id: A0A0E3NAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

523844:MSTHT RS13050
gene id: 523844:MSTHT_RS13050
uniprot id: A0A0E3KQE4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

523844:MSTHT RS01640
gene id: 523844:MSTHT_RS01640
uniprot id: A0A0E3KNU6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

523844:MSTHT RS04635
gene id: 523844:MSTHT_RS04635
uniprot id: A0A0E3KP90
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

523844:MSTHT RS03165
gene id: 523844:MSTHT_RS03165
uniprot id: A0A0E3KY91
names: Similarity
messages: Belongs to the UPF0280 family.

523844:MSTHT RS10995
gene id: 523844:MSTHT_RS10995
uniprot id: A0A0E3ND49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

523844:MSTHT RS10200
gene id: 523844:MSTHT_RS10200
uniprot id: A0A0E3KZ57
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS09405
gene id: 523844:MSTHT_RS09405
uniprot id: A0A0E3NDR6
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

523844:MSTHT RS07660
gene id: 523844:MSTHT_RS07660
uniprot id: A0A0E3KPR1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06140
gene id: 523844:MSTHT_RS06140
uniprot id: A0A0E3KYR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS09670
gene id: 523844:MSTHT_RS09670
uniprot id: A0A0E3NCB9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

523844:MSTHT RS12610
gene id: 523844:MSTHT_RS12610
uniprot id: A0A0E3ND37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523844:MSTHT RS11050
gene id: 523844:MSTHT_RS11050
uniprot id: A0A0E3KZ84
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS04495
gene id: 523844:MSTHT_RS04495
uniprot id: A0A0E3H8M4
names: Subcellular Location Annotation
messages: Cytoplasm

523844:MSTHT RS04515
gene id: 523844:MSTHT_RS04515
uniprot id: A0A0E3N8G1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523844:MSTHT RS05015
gene id: 523844:MSTHT_RS05015
uniprot id: A0A0E3NBQ1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

523844:MSTHT RS11075
gene id: 523844:MSTHT_RS11075
uniprot id: A0A0E3KZ85
names: Similarity
messages: Belongs to the Ahb/Nir family.

523844:MSTHT RS09955
gene id: 523844:MSTHT_RS09955
uniprot id: A0A0E3KZ48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

523844:MSTHT RS08380
gene id: 523844:MSTHT_RS08380
uniprot id: A0A0E3N9G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

523844:MSTHT RS06615
gene id: 523844:MSTHT_RS06615
uniprot id: A0A0E3NEH0
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

523844:MSTHT RS03965
gene id: 523844:MSTHT_RS03965
uniprot id: A0A0E3H8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

523844:MSTHT RS06060
gene id: 523844:MSTHT_RS06060
uniprot id: A0A0E3KPJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

523844:MSTHT RS04450
gene id: 523844:MSTHT_RS04450
uniprot id: A0A0E3KP69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

523844:MSTHT RS10115
gene id: 523844:MSTHT_RS10115
uniprot id: A0A0E3NDY7
names: Similarity
messages: Belongs to the aspartokinase family.

523844:MSTHT RS01540
gene id: 523844:MSTHT_RS01540
uniprot id: A0A0E3NA21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

523844:MSTHT RS10680
gene id: 523844:MSTHT_RS10680
uniprot id: A0A0E3NCM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS06760
gene id: 523844:MSTHT_RS06760
uniprot id: A0A0E3H8W0
names: Similarity
messages: Belongs to the archaeal-type GPI family.

523844:MSTHT RS01715
gene id: 523844:MSTHT_RS01715
uniprot id: A0A0E3N7G9
names: Similarity
messages: Belongs to the SDO1/SBDS family.

523844:MSTHT RS11900
gene id: 523844:MSTHT_RS11900
uniprot id: A0A0E3NEE1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HdrD family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Methanophenazine seems to mediate electron transfer from F(420)H(2) dehydrogenase to the dihydromethanophenazine:CoB--CoM heterodisulfide reductase.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B) (PubMed:9654152, PubMed:9665708, PubMed:11034998). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB (PubMed:11034998).
messages: The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE.

523844:MSTHT RS10355
gene id: 523844:MSTHT_RS10355
uniprot id: A0A0E3NCZ8
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS04470
gene id: 523844:MSTHT_RS04470
uniprot id: A0A0E3H8M3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523844:MSTHT RS13015
gene id: 523844:MSTHT_RS13015
uniprot id: A0A0E3NEN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

523844:MSTHT RS02050
gene id: 523844:MSTHT_RS02050
uniprot id: A0A0E3KNW0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

523844:MSTHT RS12320
gene id: 523844:MSTHT_RS12320
uniprot id: A0A0E3H9G7
names: Similarity
messages: Belongs to the UPF0284 family.

523844:MSTHT RS08185
gene id: 523844:MSTHT_RS08185
uniprot id: A0A0E3KYY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS00890
gene id: 523844:MSTHT_RS00890
uniprot id: A0A0E3KNS3
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

523844:MSTHT RS08690
gene id: 523844:MSTHT_RS08690
uniprot id: A0A0E3NC27
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

523844:MSTHT RS04130
gene id: 523844:MSTHT_RS04130
uniprot id: A0A0E3NAR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

523844:MSTHT RS05335
gene id: 523844:MSTHT_RS05335
uniprot id: A0A0E3NB36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

523844:MSTHT RS00635
gene id: 523844:MSTHT_RS00635
uniprot id: A0A0E3KNR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

523844:MSTHT RS11710
gene id: 523844:MSTHT_RS11710
uniprot id: A0A0E3KZA6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS13315
gene id: 523844:MSTHT_RS13315
uniprot id: A0A0E3NG52
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523844:MSTHT RS11785
gene id: 523844:MSTHT_RS11785
uniprot id: A0A0E3KQ77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

523844:MSTHT RS00615
gene id: 523844:MSTHT_RS00615
uniprot id: A0A0E3H875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

523844:MSTHT RS11770
gene id: 523844:MSTHT_RS11770
uniprot id: A0A0E3KZA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

523844:MSTHT RS03455
gene id: 523844:MSTHT_RS03455
uniprot id: A0A0E3KP20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

523844:MSTHT RS03410
gene id: 523844:MSTHT_RS03410
uniprot id: A0A0E3H8I2
names: Subcellular Location Annotation
messages: Cell membrane

523844:MSTHT RS02090
gene id: 523844:MSTHT_RS02090
uniprot id: A0A0E3N7J6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS00295
gene id: 523844:MSTHT_RS00295
uniprot id: A0A0E3KNQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS07050
gene id: 523844:MSTHT_RS07050
uniprot id: A0A0E3KPN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

523844:MSTHT RS00875
gene id: 523844:MSTHT_RS00875
uniprot id: A0A0E3H884
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06690
gene id: 523844:MSTHT_RS06690
uniprot id: A0A0E3NBE0
names: Similarity
messages: Belongs to the AHA1 family.

523844:MSTHT RS06445
gene id: 523844:MSTHT_RS06445
uniprot id: A0A0E3KPL1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

523844:MSTHT RS11495
gene id: 523844:MSTHT_RS11495
uniprot id: A0A0E3NAA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

523844:MSTHT RS09365
gene id: 523844:MSTHT_RS09365
uniprot id: A0A0E3KPY3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523844:MSTHT RS08125
gene id: 523844:MSTHT_RS08125
uniprot id: A0A0E3H913
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523844:MSTHT RS08685
gene id: 523844:MSTHT_RS08685
uniprot id: A0A0E3KZ06
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

523844:MSTHT RS01055
gene id: 523844:MSTHT_RS01055
uniprot id: A0A0E3N9X8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

523844:MSTHT RS12245
gene id: 523844:MSTHT_RS12245
uniprot id: A0A0E3NFV4
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06635
gene id: 523844:MSTHT_RS06635
uniprot id: A0A0E3NBD7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS10715
gene id: 523844:MSTHT_RS10715
uniprot id: A0A0E3NE39
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

523844:MSTHT RS01005
gene id: 523844:MSTHT_RS01005
uniprot id: A0A0E3NAN2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523844:MSTHT RS11045
gene id: 523844:MSTHT_RS11045
uniprot id: A0A0E3ND54
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS05925
gene id: 523844:MSTHT_RS05925
uniprot id: A0A0E3N8V5
names: Similarity
messages: Belongs to the peptidase S8 family.

523844:MSTHT RS11345
gene id: 523844:MSTHT_RS11345
uniprot id: A0A0E3KZ94
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523844:MSTHT RS06075
gene id: 523844:MSTHT_RS06075
uniprot id: A0A0E3H8T4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS05255
gene id: 523844:MSTHT_RS05255
uniprot id: A0A0E3NE41
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

523844:MSTHT RS02810
gene id: 523844:MSTHT_RS02810
uniprot id: A0A0E3KY70
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06050
gene id: 523844:MSTHT_RS06050
uniprot id: A0A0E3H8T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

523844:MSTHT RS11490
gene id: 523844:MSTHT_RS11490
uniprot id: A0A0E3KQ66
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

523844:MSTHT RS02715
gene id: 523844:MSTHT_RS02715
uniprot id: A0A0E3KY62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

523844:MSTHT RS01145
gene id: 523844:MSTHT_RS01145
uniprot id: A0A0E3NCY2
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS04160
gene id: 523844:MSTHT_RS04160
uniprot id: A0A0E3NDT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

523844:MSTHT RS11470
gene id: 523844:MSTHT_RS11470
uniprot id: A0A0E3NCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

523844:MSTHT RS09510
gene id: 523844:MSTHT_RS09510
uniprot id: A0A0E3H964
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

523844:MSTHT RS04000
gene id: 523844:MSTHT_RS04000
uniprot id: A0A0E3NDR8
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

523844:MSTHT RS05920
gene id: 523844:MSTHT_RS05920
uniprot id: A0A0E3NBW2
names: Similarity
messages: Belongs to the HypE family.

523844:MSTHT RS00630
gene id: 523844:MSTHT_RS00630
uniprot id: A0A0E3NBR6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS10570
gene id: 523844:MSTHT_RS10570
uniprot id: A0A0E3H9A3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

523844:MSTHT RS10400
gene id: 523844:MSTHT_RS10400
uniprot id: A0A0E3NCK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

523844:MSTHT RS08615
gene id: 523844:MSTHT_RS08615
uniprot id: A0A0E3NEZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523844:MSTHT RS04070
gene id: 523844:MSTHT_RS04070
uniprot id: A0A0E3H8K7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS04075
gene id: 523844:MSTHT_RS04075
uniprot id: A0A0E3KP46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

523844:MSTHT RS00860
gene id: 523844:MSTHT_RS00860
uniprot id: A0A0E3KNS2
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS07505
gene id: 523844:MSTHT_RS07505
uniprot id: A0A0E3KYW5
names: Similarity
messages: Belongs to the TrpF family.

523844:MSTHT RS09385
gene id: 523844:MSTHT_RS09385
uniprot id: A0A0E3KZ29
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS02270
gene id: 523844:MSTHT_RS02270
uniprot id: A0A0E3NC15
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

523844:MSTHT RS06025
gene id: 523844:MSTHT_RS06025
uniprot id: A0A0E3H8T2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

523844:MSTHT RS10690
gene id: 523844:MSTHT_RS10690
uniprot id: A0A0E3KZ73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS02095
gene id: 523844:MSTHT_RS02095
uniprot id: A0A0E3ND69
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS02030
gene id: 523844:MSTHT_RS02030
uniprot id: A0A0E3N7I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

523844:MSTHT RS05795
gene id: 523844:MSTHT_RS05795
uniprot id: A0A0E3NCZ2
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

523844:MSTHT RS08775
gene id: 523844:MSTHT_RS08775
uniprot id: A0A0E3KZ09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

523844:MSTHT RS04045
gene id: 523844:MSTHT_RS04045
uniprot id: A0A0E3KP44
names: Similarity
messages: Belongs to the UPF0210 family.

523844:MSTHT RS13445
gene id: 523844:MSTHT_RS13445
uniprot id: A0A0E3H9L1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523844:MSTHT RS11440
gene id: 523844:MSTHT_RS11440
uniprot id: A0A0E3NAA3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

523844:MSTHT RS06115
gene id: 523844:MSTHT_RS06115
uniprot id: A0A0E3NEC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS07130
gene id: 523844:MSTHT_RS07130
uniprot id: A0A0E3H8X4
names: Similarity
messages: Belongs to the peptidase S8 family.

523844:MSTHT RS09030
gene id: 523844:MSTHT_RS09030
uniprot id: A0A0E3NCL0
names: Similarity
messages: Belongs to the HisA/HisF family.

523844:MSTHT RS12040
gene id: 523844:MSTHT_RS12040
uniprot id: A0A0E3NCY4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523844:MSTHT RS01855
gene id: 523844:MSTHT_RS01855
uniprot id: A0A0E3H8C2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

523844:MSTHT RS10070
gene id: 523844:MSTHT_RS10070
uniprot id: A0A0E3NCH2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

523844:MSTHT RS02645
gene id: 523844:MSTHT_RS02645
uniprot id: A0A0E3KY58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523844:MSTHT RS07415
gene id: 523844:MSTHT_RS07415
uniprot id: A0A0E3KPQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

523844:MSTHT RS10185
gene id: 523844:MSTHT_RS10185
uniprot id: A0A0E3NCY1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS09040
gene id: 523844:MSTHT_RS09040
uniprot id: A0A0E3KZ18
names: Similarity
messages: Belongs to the thymidylate kinase family.

523844:MSTHT RS08270
gene id: 523844:MSTHT_RS08270
uniprot id: A0A0E3NCE9
names: Similarity
messages: Belongs to the HdrC family.

523844:MSTHT RS07075
gene id: 523844:MSTHT_RS07075
uniprot id: A0A0E3NBG2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS09055
gene id: 523844:MSTHT_RS09055
uniprot id: A0A0E3KPX1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

523844:MSTHT RS02410
gene id: 523844:MSTHT_RS02410
uniprot id: A0A0E3H8E4
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10780
gene id: 523844:MSTHT_RS10780
uniprot id: A0A0E3NCN7
names: Similarity
messages: Belongs to the citrate synthase family.

523844:MSTHT RS07080
gene id: 523844:MSTHT_RS07080
uniprot id: A0A0E3H8X2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS08580
gene id: 523844:MSTHT_RS08580
uniprot id: A0A0E3H930
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523844:MSTHT RS12080
gene id: 523844:MSTHT_RS12080
uniprot id: A0A0E3H9F9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

523844:MSTHT RS11070
gene id: 523844:MSTHT_RS11070
uniprot id: A0A0E3NE72
names: Similarity
messages: Belongs to the Ahb/Nir family.

523844:MSTHT RS11105
gene id: 523844:MSTHT_RS11105
uniprot id: A0A0E3KZ86
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS06170
gene id: 523844:MSTHT_RS06170
uniprot id: A0A0E3KYR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

523844:MSTHT RS07965
gene id: 523844:MSTHT_RS07965
uniprot id: A0A0E3KYY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523844:MSTHT RS13415
gene id: 523844:MSTHT_RS13415
uniprot id: A0A0E3KQH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

523844:MSTHT RS06995
gene id: 523844:MSTHT_RS06995
uniprot id: A0A0E3NEK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

523844:MSTHT RS11125
gene id: 523844:MSTHT_RS11125
uniprot id: A0A0E3NE76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

523844:MSTHT RS07015
gene id: 523844:MSTHT_RS07015
uniprot id: A0A0E3KPN7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

523844:MSTHT RS02065
gene id: 523844:MSTHT_RS02065
uniprot id: A0A0E3NA77
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS05020
gene id: 523844:MSTHT_RS05020
uniprot id: A0A0E3KPD4
names: Similarity
messages: Belongs to the UPF0228 family.

523844:MSTHT RS05000
gene id: 523844:MSTHT_RS05000
uniprot id: A0A0E3NB16
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

523844:MSTHT RS11305
gene id: 523844:MSTHT_RS11305
uniprot id: A0A0E3H9D0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523844:MSTHT RS12240
gene id: 523844:MSTHT_RS12240
uniprot id: A0A0E3KQA2
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS08120
gene id: 523844:MSTHT_RS08120
uniprot id: A0A0E3KYY7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

523844:MSTHT RS01720
gene id: 523844:MSTHT_RS01720
uniprot id: A0A0E3KY18
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523844:MSTHT RS07155
gene id: 523844:MSTHT_RS07155
uniprot id: A0A0E3N944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

523844:MSTHT RS07640
gene id: 523844:MSTHT_RS07640
uniprot id: A0A0E3N997
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

523844:MSTHT RS05690
gene id: 523844:MSTHT_RS05690
uniprot id: A0A0E3KPH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

523844:MSTHT RS08455
gene id: 523844:MSTHT_RS08455
uniprot id: A0A0E3NDI2
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS09895
gene id: 523844:MSTHT_RS09895
uniprot id: A0A0E3NCF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

523844:MSTHT RS00420
gene id: 523844:MSTHT_RS00420
uniprot id: A0A0E3H869
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS01550
gene id: 523844:MSTHT_RS01550
uniprot id: A0A0E3KNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

523844:MSTHT RS07945
gene id: 523844:MSTHT_RS07945
uniprot id: A0A0E3KPS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

523844:MSTHT RS08065
gene id: 523844:MSTHT_RS08065
uniprot id: A0A0E3NEV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

523844:MSTHT RS03255
gene id: 523844:MSTHT_RS03255
uniprot id: A0A0E3NAI1
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

523844:MSTHT RS12380
gene id: 523844:MSTHT_RS12380
uniprot id: A0A0E3NEH5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523844:MSTHT RS01075
gene id: 523844:MSTHT_RS01075
uniprot id: A0A0E3N7C2
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS07680
gene id: 523844:MSTHT_RS07680
uniprot id: A0A0E3H8Z5
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS02960
gene id: 523844:MSTHT_RS02960
uniprot id: A0A0E3N7S4
names: Similarity
messages: Belongs to the class-I fumarase family.

523844:MSTHT RS05520
gene id: 523844:MSTHT_RS05520
uniprot id: A0A0E3H8R3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523844:MSTHT RS02990
gene id: 523844:MSTHT_RS02990
uniprot id: A0A0E3NAG3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

523844:MSTHT RS00250
gene id: 523844:MSTHT_RS00250
uniprot id: A0A0E3NBP7
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS01950
gene id: 523844:MSTHT_RS01950
uniprot id: A0A0E3NBY7
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523844:MSTHT RS01290
gene id: 523844:MSTHT_RS01290
uniprot id: A0A0E3KNT5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

523844:MSTHT RS12505
gene id: 523844:MSTHT_RS12505
uniprot id: A0A0E3NDE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

523844:MSTHT RS06405
gene id: 523844:MSTHT_RS06405
uniprot id: A0A0E3NBC0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS03310
gene id: 523844:MSTHT_RS03310
uniprot id: A0A0E3KP15
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

523844:MSTHT RS09945
gene id: 523844:MSTHT_RS09945
uniprot id: A0A0E3H980
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523844:MSTHT RS09425
gene id: 523844:MSTHT_RS09425
uniprot id: A0A0E3KZ31
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10945
gene id: 523844:MSTHT_RS10945
uniprot id: A0A0E3KZ81
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS10140
gene id: 523844:MSTHT_RS10140
uniprot id: A0A0E3KQ18
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

523844:MSTHT RS02210
gene id: 523844:MSTHT_RS02210
uniprot id: A0A0E3NC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523844:MSTHT RS08515
gene id: 523844:MSTHT_RS08515
uniprot id: A0A0E3KZ00
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523844:MSTHT RS12700
gene id: 523844:MSTHT_RS12700
uniprot id: A0A0E3NEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

523844:MSTHT RS04355
gene id: 523844:MSTHT_RS04355
uniprot id: A0A0E3KP63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523844:MSTHT RS00980
gene id: 523844:MSTHT_RS00980
uniprot id: A0A0E3NCX0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523844:MSTHT RS01040
gene id: 523844:MSTHT_RS01040
uniprot id: A0A0E3H890
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS08060
gene id: 523844:MSTHT_RS08060
uniprot id: A0A0E3KYY5
names: Similarity
messages: Belongs to the AOR/FOR family.

523844:MSTHT RS04840
gene id: 523844:MSTHT_RS04840
uniprot id: A0A0E3KYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS10065
gene id: 523844:MSTHT_RS10065
uniprot id: A0A0E3KZ51
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

523844:MSTHT RS06110
gene id: 523844:MSTHT_RS06110
uniprot id: A0A0E3KYR6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

523844:MSTHT RS06345
gene id: 523844:MSTHT_RS06345
uniprot id: A0A0E3ND36
names: Subcellular Location Annotation
messages: Cell membrane

523844:MSTHT RS09830
gene id: 523844:MSTHT_RS09830
uniprot id: A0A0E3KQ01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS05435
gene id: 523844:MSTHT_RS05435
uniprot id: A0A0E3NB44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

523844:MSTHT RS13365
gene id: 523844:MSTHT_RS13365
uniprot id: A0A0E3NDL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

523844:MSTHT RS12400
gene id: 523844:MSTHT_RS12400
uniprot id: A0A0E3NDE3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

523844:MSTHT RS10540
gene id: 523844:MSTHT_RS10540
uniprot id: A0A0E3KQ32
names: Similarity
messages: Belongs to the peptidase M24B family.

523844:MSTHT RS09775
gene id: 523844:MSTHT_RS09775
uniprot id: A0A0E3H974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523844:MSTHT RS07925
gene id: 523844:MSTHT_RS07925
uniprot id: A0A0E3KPS1
names: Similarity
messages: Belongs to the PurH family.

523844:MSTHT RS08520
gene id: 523844:MSTHT_RS08520
uniprot id: A0A0E3H928
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS01020
gene id: 523844:MSTHT_RS01020
uniprot id: A0A0E3KXY2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523844:MSTHT RS09835
gene id: 523844:MSTHT_RS09835
uniprot id: A0A0E3H976
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523844:MSTHT RS07555
gene id: 523844:MSTHT_RS07555
uniprot id: A0A0E3H8Z0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523844:MSTHT RS04680
gene id: 523844:MSTHT_RS04680
uniprot id: A0A0E3N8I1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

523844:MSTHT RS01215
gene id: 523844:MSTHT_RS01215
uniprot id: A0A0E3KXZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

523844:MSTHT RS07535
gene id: 523844:MSTHT_RS07535
uniprot id: A0A0E3KYW6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

523844:MSTHT RS06135
gene id: 523844:MSTHT_RS06135
uniprot id: A0A0E3NBA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

523844:MSTHT RS10645
gene id: 523844:MSTHT_RS10645
uniprot id: A0A0E3NA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

523844:MSTHT RS12820
gene id: 523844:MSTHT_RS12820
uniprot id: A0A0E3KZE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

523844:MSTHT RS10165
gene id: 523844:MSTHT_RS10165
uniprot id: A0A0E3NDZ4
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

523844:MSTHT RS08130
gene id: 523844:MSTHT_RS08130
uniprot id: A0A0E3NDF7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS06165
gene id: 523844:MSTHT_RS06165
uniprot id: A0A0E3NED1
names: Similarity
messages: Belongs to the archaeal-type GPI family.

523844:MSTHT RS09980
gene id: 523844:MSTHT_RS09980
uniprot id: A0A0E3N9X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523844:MSTHT RS10330
gene id: 523844:MSTHT_RS10330
uniprot id: A0A0E3KZ61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523844:MSTHT RS10485
gene id: 523844:MSTHT_RS10485
uniprot id: A0A0E3H9A0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS06015
gene id: 523844:MSTHT_RS06015
uniprot id: A0A0E3KYR3
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS09750
gene id: 523844:MSTHT_RS09750
uniprot id: A0A0E3H973
names: Function
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

523844:MSTHT RS06065
gene id: 523844:MSTHT_RS06065
uniprot id: A0A0E3NEB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

523844:MSTHT RS01415
gene id: 523844:MSTHT_RS01415
uniprot id: A0A0E3KY02
names: Similarity
messages: Belongs to the UPF0111 family.

523844:MSTHT RS04490
gene id: 523844:MSTHT_RS04490
uniprot id: A0A0E3NAV7
names: Similarity
messages: Belongs to the glutaredoxin family.

523844:MSTHT RS01625
gene id: 523844:MSTHT_RS01625
uniprot id: A0A0E3N7G1
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudC subfamily.

523844:MSTHT RS11250
gene id: 523844:MSTHT_RS11250
uniprot id: A0A0E3NCS5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

523844:MSTHT RS04015
gene id: 523844:MSTHT_RS04015
uniprot id: A0A0E3KP43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

523844:MSTHT RS07275
gene id: 523844:MSTHT_RS07275
uniprot id: A0A0E3KYV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

523844:MSTHT RS10060
gene id: 523844:MSTHT_RS10060
uniprot id: A0A0E3H984
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

523844:MSTHT RS05840
gene id: 523844:MSTHT_RS05840
uniprot id: A0A0E3KYQ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

523844:MSTHT RS07590
gene id: 523844:MSTHT_RS07590
uniprot id: A0A0E3N992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

523844:MSTHT RS10515
gene id: 523844:MSTHT_RS10515
uniprot id: A0A0E3NCL2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS06030
gene id: 523844:MSTHT_RS06030
uniprot id: A0A0E3KPI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

523844:MSTHT RS03790
gene id: 523844:MSTHT_RS03790
uniprot id: A0A0E3KYD0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS13535
gene id: 523844:MSTHT_RS13535
uniprot id: A0A0E3H9L4
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

523844:MSTHT RS01865
gene id: 523844:MSTHT_RS01865
uniprot id: A0A0E3NAS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

523844:MSTHT RS08445
gene id: 523844:MSTHT_RS08445
uniprot id: A0A0E3NEY8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS03615
gene id: 523844:MSTHT_RS03615
uniprot id: A0A0E3KYC1
names: Similarity
messages: Belongs to the UPF0237 family.

523844:MSTHT RS08645
gene id: 523844:MSTHT_RS08645
uniprot id: A0A0E3NCI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523844:MSTHT RS09545
gene id: 523844:MSTHT_RS09545
uniprot id: A0A0E3H965
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

523844:MSTHT RS03710
gene id: 523844:MSTHT_RS03710
uniprot id: A0A0E3NBC9
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS08935
gene id: 523844:MSTHT_RS08935
uniprot id: A0A0E3N9L4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

523844:MSTHT RS07070
gene id: 523844:MSTHT_RS07070
uniprot id: A0A0E3KYV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523844:MSTHT RS05865
gene id: 523844:MSTHT_RS05865
uniprot id: A0A0E3NBW0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

523844:MSTHT RS06145
gene id: 523844:MSTHT_RS06145
uniprot id: A0A0E3NBX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

523844:MSTHT RS06540
gene id: 523844:MSTHT_RS06540
uniprot id: A0A0E3KYT2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523844:MSTHT RS08575
gene id: 523844:MSTHT_RS08575
uniprot id: A0A0E3NDJ4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523844:MSTHT RS12500
gene id: 523844:MSTHT_RS12500
uniprot id: A0A0E3KZD2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

523844:MSTHT RS10120
gene id: 523844:MSTHT_RS10120
uniprot id: A0A0E3NCH8
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523844:MSTHT RS06435
gene id: 523844:MSTHT_RS06435
uniprot id: A0A0E3H8U8
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

523844:MSTHT RS12845
gene id: 523844:MSTHT_RS12845
uniprot id: A0A0E3NG14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

523844:MSTHT RS05205
gene id: 523844:MSTHT_RS05205
uniprot id: A0A0E3NCT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

523844:MSTHT RS04630
gene id: 523844:MSTHT_RS04630
uniprot id: A0A0E3NDZ0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

523844:MSTHT RS12495
gene id: 523844:MSTHT_RS12495
uniprot id: A0A0E3H9H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

523844:MSTHT RS01445
gene id: 523844:MSTHT_RS01445
uniprot id: A0A0E3NAQ5
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS05900
gene id: 523844:MSTHT_RS05900
uniprot id: A0A0E3KYQ9
names: Similarity
messages: Belongs to the HupF/HypC family.

523844:MSTHT RS03630
gene id: 523844:MSTHT_RS03630
uniprot id: A0A0E3NDN1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS03900
gene id: 523844:MSTHT_RS03900
uniprot id: A0A0E3KP39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523844:MSTHT RS01060
gene id: 523844:MSTHT_RS01060
uniprot id: A0A0E3KNS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS03155
gene id: 523844:MSTHT_RS03155
uniprot id: A0A0E3NB40
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523844:MSTHT RS10005
gene id: 523844:MSTHT_RS10005
uniprot id: A0A0E3NDX6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS00895
gene id: 523844:MSTHT_RS00895
uniprot id: A0A0E3NAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

523844:MSTHT RS04700
gene id: 523844:MSTHT_RS04700
uniprot id: A0A0E3NCQ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

523844:MSTHT RS11200
gene id: 523844:MSTHT_RS11200
uniprot id: A0A0E3NCS1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

523844:MSTHT RS09715
gene id: 523844:MSTHT_RS09715
uniprot id: A0A0E3KZ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523844:MSTHT RS12360
gene id: 523844:MSTHT_RS12360
uniprot id: A0A0E3NAK5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

523844:MSTHT RS04545
gene id: 523844:MSTHT_RS04545
uniprot id: A0A0E3H8M6
names: Similarity
messages: Belongs to the TPP enzyme family.

523844:MSTHT RS01875
gene id: 523844:MSTHT_RS01875
uniprot id: A0A0E3KY25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

523844:MSTHT RS00400
gene id: 523844:MSTHT_RS00400
uniprot id: A0A0E3NAJ4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS02060
gene id: 523844:MSTHT_RS02060
uniprot id: A0A0E3H8D0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

523844:MSTHT RS12100
gene id: 523844:MSTHT_RS12100
uniprot id: A0A0E3KQ94
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

523844:MSTHT RS07905
gene id: 523844:MSTHT_RS07905
uniprot id: A0A0E3N9C2
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10160
gene id: 523844:MSTHT_RS10160
uniprot id: A0A0E3H988
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

523844:MSTHT RS08405
gene id: 523844:MSTHT_RS08405
uniprot id: A0A0E3NDI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523844:MSTHT RS04120
gene id: 523844:MSTHT_RS04120
uniprot id: A0A0E3H8K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

523844:MSTHT RS11695
gene id: 523844:MSTHT_RS11695
uniprot id: A0A0E3NCV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

523844:MSTHT RS04720
gene id: 523844:MSTHT_RS04720
uniprot id: A0A0E3NAY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523844:MSTHT RS03195
gene id: 523844:MSTHT_RS03195
uniprot id: A0A0E3H8H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

523844:MSTHT RS06125
gene id: 523844:MSTHT_RS06125
uniprot id: A0A0E3H8T6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

523844:MSTHT RS13070
gene id: 523844:MSTHT_RS13070
uniprot id: A0A0E3KZF2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS00135
gene id: 523844:MSTHT_RS00135
uniprot id: A0A0E3NCQ4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS07060
gene id: 523844:MSTHT_RS07060
uniprot id: A0A0E3NEL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

523844:MSTHT RS01740
gene id: 523844:MSTHT_RS01740
uniprot id: A0A0E3NBX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

523844:MSTHT RS11875
gene id: 523844:MSTHT_RS11875
uniprot id: A0A0E3NAF1
names: Similarity
messages: Belongs to the MCM family.

523844:MSTHT RS04475
gene id: 523844:MSTHT_RS04475
uniprot id: A0A0E3NDX1
names: Similarity
messages: Belongs to the UPF0212 family.

523844:MSTHT RS10980
gene id: 523844:MSTHT_RS10980
uniprot id: A0A0E3NCQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS04350
gene id: 523844:MSTHT_RS04350
uniprot id: A0A0E3NBL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523844:MSTHT RS02415
gene id: 523844:MSTHT_RS02415
uniprot id: A0A0E3KY46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS04125
gene id: 523844:MSTHT_RS04125
uniprot id: A0A0E3KYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

523844:MSTHT RS11880
gene id: 523844:MSTHT_RS11880
uniprot id: A0A0E3H9F2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

523844:MSTHT RS03550
gene id: 523844:MSTHT_RS03550
uniprot id: A0A0E3H8I7
names: Caution
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS09530
gene id: 523844:MSTHT_RS09530
uniprot id: A0A0E3KPY7
names: Subcellular Location Annotation
messages: Cytoplasm

523844:MSTHT RS11260
gene id: 523844:MSTHT_RS11260
uniprot id: A0A0E3ND68
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523844:MSTHT RS05485
gene id: 523844:MSTHT_RS05485
uniprot id: A0A0E3NB50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

523844:MSTHT RS11430
gene id: 523844:MSTHT_RS11430
uniprot id: A0A0E3ND81
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS07545
gene id: 523844:MSTHT_RS07545
uniprot id: A0A0E3KPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523844:MSTHT RS06080
gene id: 523844:MSTHT_RS06080
uniprot id: A0A0E3KYR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

523844:MSTHT RS12180
gene id: 523844:MSTHT_RS12180
uniprot id: A0A0E3NAJ1
names: Cofactor
messages: Binds 1 zinc ion per subunit.

523844:MSTHT RS01810
gene id: 523844:MSTHT_RS01810
uniprot id: A0A0E3H8C0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

523844:MSTHT RS12900
gene id: 523844:MSTHT_RS12900
uniprot id: A0A0E3NG20
names: Cofactor
messages: Binds 1 zinc ion per subunit.

523844:MSTHT RS02380
gene id: 523844:MSTHT_RS02380
uniprot id: A0A0E3NC23
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

523844:MSTHT RS03145
gene id: 523844:MSTHT_RS03145
uniprot id: A0A0E3NAH1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

523844:MSTHT RS10155
gene id: 523844:MSTHT_RS10155
uniprot id: A0A0E3KZ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

523844:MSTHT RS05800
gene id: 523844:MSTHT_RS05800
uniprot id: A0A0E3NB74
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

523844:MSTHT RS11985
gene id: 523844:MSTHT_RS11985
uniprot id: A0A0E3H9F6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

523844:MSTHT RS03800
gene id: 523844:MSTHT_RS03800
uniprot id: A0A0E3H8J7
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10235
gene id: 523844:MSTHT_RS10235
uniprot id: A0A0E3NCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

523844:MSTHT RS06685
gene id: 523844:MSTHT_RS06685
uniprot id: A0A0E3KPM0
names: Similarity
messages: Belongs to the AHA1 family.

523844:MSTHT RS03980
gene id: 523844:MSTHT_RS03980
uniprot id: A0A0E3NBH5
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

523844:MSTHT RS04330
gene id: 523844:MSTHT_RS04330
uniprot id: A0A0E3KP61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523844:MSTHT RS15170
gene id: 523844:MSTHT_RS15170
uniprot id: A0A0E3NC05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS02345
gene id: 523844:MSTHT_RS02345
uniprot id: A0A0E3KNX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

523844:MSTHT RS01185
gene id: 523844:MSTHT_RS01185
uniprot id: A0A0E3KXZ0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

523844:MSTHT RS09370
gene id: 523844:MSTHT_RS09370
uniprot id: A0A0E3NCN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

523844:MSTHT RS08600
gene id: 523844:MSTHT_RS08600
uniprot id: A0A0E3KPV4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

523844:MSTHT RS11825
gene id: 523844:MSTHT_RS11825
uniprot id: A0A0E3H9F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523844:MSTHT RS09085
gene id: 523844:MSTHT_RS09085
uniprot id: A0A0E3NCL4
names: Subcellular Location Annotation
messages: Cell membrane

523844:MSTHT RS11800
gene id: 523844:MSTHT_RS11800
uniprot id: A0A0E3H9E9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

523844:MSTHT RS08205
gene id: 523844:MSTHT_RS08205
uniprot id: A0A0E3H916
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

523844:MSTHT RS06105
gene id: 523844:MSTHT_RS06105
uniprot id: A0A0E3N8W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523844:MSTHT RS12835
gene id: 523844:MSTHT_RS12835
uniprot id: A0A0E3KQD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

523844:MSTHT RS01795
gene id: 523844:MSTHT_RS01795
uniprot id: A0A0E3NBX5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS07960
gene id: 523844:MSTHT_RS07960
uniprot id: A0A0E3NEU9
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

523844:MSTHT RS08635
gene id: 523844:MSTHT_RS08635
uniprot id: A0A0E3KPV6
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

523844:MSTHT RS11690
gene id: 523844:MSTHT_RS11690
uniprot id: A0A0E3KQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

523844:MSTHT RS05145
gene id: 523844:MSTHT_RS05145
uniprot id: A0A0E3NE31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

523844:MSTHT RS12615
gene id: 523844:MSTHT_RS12615
uniprot id: A0A0E3KQC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523844:MSTHT RS08545
gene id: 523844:MSTHT_RS08545
uniprot id: A0A0E3NCH3
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS04235
gene id: 523844:MSTHT_RS04235
uniprot id: A0A0E3NCH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

523844:MSTHT RS09645
gene id: 523844:MSTHT_RS09645
uniprot id: A0A0E3NF71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

523844:MSTHT RS02740
gene id: 523844:MSTHT_RS02740
uniprot id: A0A0E3NDB5
names: Similarity
messages: Belongs to the TrpC family.

523844:MSTHT RS08435
gene id: 523844:MSTHT_RS08435
uniprot id: A0A0E3N9G7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

523844:MSTHT RS11230
gene id: 523844:MSTHT_RS11230
uniprot id: A0A0E3NFL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

523844:MSTHT RS03945
gene id: 523844:MSTHT_RS03945
uniprot id: A0A0E3KP40
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

523844:MSTHT RS12990
gene id: 523844:MSTHT_RS12990
uniprot id: A0A0E3KQE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

523844:MSTHT RS11795
gene id: 523844:MSTHT_RS11795
uniprot id: A0A0E3NCW5
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

523844:MSTHT RS13495
gene id: 523844:MSTHT_RS13495
uniprot id: A0A0E3KZL2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523844:MSTHT RS05295
gene id: 523844:MSTHT_RS05295
uniprot id: A0A0E3NBR7
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

523844:MSTHT RS04405
gene id: 523844:MSTHT_RS04405
uniprot id: A0A0E3KYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

523844:MSTHT RS05710
gene id: 523844:MSTHT_RS05710
uniprot id: A0A0E3KYQ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS10495
gene id: 523844:MSTHT_RS10495
uniprot id: A0A0E3KZ67
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS08470
gene id: 523844:MSTHT_RS08470
uniprot id: A0A0E3NC00
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

523844:MSTHT RS10480
gene id: 523844:MSTHT_RS10480
uniprot id: A0A0E3NA24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS05140
gene id: 523844:MSTHT_RS05140
uniprot id: A0A0E3H8P8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

523844:MSTHT RS09400
gene id: 523844:MSTHT_RS09400
uniprot id: A0A0E3H961
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

523844:MSTHT RS05805
gene id: 523844:MSTHT_RS05805
uniprot id: A0A0E3H8S4
names: Similarity
messages: Belongs to the UPF0047 family.

523844:MSTHT RS07265
gene id: 523844:MSTHT_RS07265
uniprot id: A0A0E3N956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

523844:MSTHT RS10675
gene id: 523844:MSTHT_RS10675
uniprot id: A0A0E3KQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS12295
gene id: 523844:MSTHT_RS12295
uniprot id: A0A0E3KZC5
names: Similarity
messages: Belongs to the pyruvate kinase family.

523844:MSTHT RS09110
gene id: 523844:MSTHT_RS09110
uniprot id: A0A0E3KZ20
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523844:MSTHT RS09940
gene id: 523844:MSTHT_RS09940
uniprot id: A0A0E3NDX3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523844:MSTHT RS02795
gene id: 523844:MSTHT_RS02795
uniprot id: A0A0E3KNZ4
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS06330
gene id: 523844:MSTHT_RS06330
uniprot id: A0A0E3NEE5
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523844:MSTHT RS11225
gene id: 523844:MSTHT_RS11225
uniprot id: A0A0E3KQ56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS07400
gene id: 523844:MSTHT_RS07400
uniprot id: A0A0E3H8Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS04550
gene id: 523844:MSTHT_RS04550
uniprot id: A0A0E3NAW3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

523844:MSTHT RS03575
gene id: 523844:MSTHT_RS03575
uniprot id: A0A0E3H8I8
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10565
gene id: 523844:MSTHT_RS10565
uniprot id: A0A0E3KZ69
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

523844:MSTHT RS10685
gene id: 523844:MSTHT_RS10685
uniprot id: A0A0E3ND30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS11355
gene id: 523844:MSTHT_RS11355
uniprot id: A0A0E3NE97
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

523844:MSTHT RS06780
gene id: 523844:MSTHT_RS06780
uniprot id: A0A0E3KPM9
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

523844:MSTHT RS06770
gene id: 523844:MSTHT_RS06770
uniprot id: A0A0E3KYU0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

523844:MSTHT RS07780
gene id: 523844:MSTHT_RS07780
uniprot id: A0A0E3NBP1
names: Similarity
messages: Belongs to the AAA ATPase family.

523844:MSTHT RS02590
gene id: 523844:MSTHT_RS02590
uniprot id: A0A0E3H8F1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS13190
gene id: 523844:MSTHT_RS13190
uniprot id: A0A0E3KZG1
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

523844:MSTHT RS09325
gene id: 523844:MSTHT_RS09325
uniprot id: A0A0E3N9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS09535
gene id: 523844:MSTHT_RS09535
uniprot id: A0A0E3NF64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

523844:MSTHT RS08665
gene id: 523844:MSTHT_RS08665
uniprot id: A0A0E3KPV7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS08290
gene id: 523844:MSTHT_RS08290
uniprot id: A0A0E3H919
names: Similarity
messages: Belongs to the UPF0251 family.

523844:MSTHT RS00755
gene id: 523844:MSTHT_RS00755
uniprot id: A0A0E3NCV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

523844:MSTHT RS08725
gene id: 523844:MSTHT_RS08725
uniprot id: A0A0E3KPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

523844:MSTHT RS05610
gene id: 523844:MSTHT_RS05610
uniprot id: A0A0E3KYP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

523844:MSTHT RS12200
gene id: 523844:MSTHT_RS12200
uniprot id: A0A0E3NEG5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523844:MSTHT RS02315
gene id: 523844:MSTHT_RS02315
uniprot id: A0A0E3H8E0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS13010
gene id: 523844:MSTHT_RS13010
uniprot id: A0A0E3KZF0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

523844:MSTHT RS07605
gene id: 523844:MSTHT_RS07605
uniprot id: A0A0E3H8Z2
names: Similarity
messages: Belongs to the UPF0235 family.

523844:MSTHT RS05615
gene id: 523844:MSTHT_RS05615
uniprot id: A0A0E3NE79
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS07380
gene id: 523844:MSTHT_RS07380
uniprot id: A0A0E3N969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523844:MSTHT RS06590
gene id: 523844:MSTHT_RS06590
uniprot id: A0A0E3KPL6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

523844:MSTHT RS08340
gene id: 523844:MSTHT_RS08340
uniprot id: A0A0E3H921
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

523844:MSTHT RS05510
gene id: 523844:MSTHT_RS05510
uniprot id: A0A0E3NE68
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523844:MSTHT RS03400
gene id: 523844:MSTHT_RS03400
uniprot id: A0A0E3KYA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

523844:MSTHT RS12850
gene id: 523844:MSTHT_RS12850
uniprot id: A0A0E3KZE4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

523844:MSTHT RS08375
gene id: 523844:MSTHT_RS08375
uniprot id: A0A0E3NCF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

523844:MSTHT RS10015
gene id: 523844:MSTHT_RS10015
uniprot id: A0A0E3KQ11
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

523844:MSTHT RS05825
gene id: 523844:MSTHT_RS05825
uniprot id: A0A0E3N8U9
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS01665
gene id: 523844:MSTHT_RS01665
uniprot id: A0A0E3KY16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS13455
gene id: 523844:MSTHT_RS13455
uniprot id: A0A0E3NDA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

523844:MSTHT RS13110
gene id: 523844:MSTHT_RS13110
uniprot id: A0A0E3NG34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS04610
gene id: 523844:MSTHT_RS04610
uniprot id: A0A0E3NBN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

523844:MSTHT RS12195
gene id: 523844:MSTHT_RS12195
uniprot id: A0A0E3H9G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

523844:MSTHT RS05755
gene id: 523844:MSTHT_RS05755
uniprot id: A0A0E3KPH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS03640
gene id: 523844:MSTHT_RS03640
uniprot id: A0A0E3NCC8
names: Similarity
messages: Belongs to the glutamine synthetase family.

523844:MSTHT RS05345
gene id: 523844:MSTHT_RS05345
uniprot id: A0A0E3NBS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS08220
gene id: 523844:MSTHT_RS08220
uniprot id: A0A0E3KYZ0
names: Similarity
messages: Belongs to the glutamate synthase family.

523844:MSTHT RS04705
gene id: 523844:MSTHT_RS04705
uniprot id: A0A0E3H8N2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

523844:MSTHT RS04460
gene id: 523844:MSTHT_RS04460
uniprot id: A0A0E3N8F6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

523844:MSTHT RS09650
gene id: 523844:MSTHT_RS09650
uniprot id: A0A0E3H969
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

523844:MSTHT RS06570
gene id: 523844:MSTHT_RS06570
uniprot id: A0A0E3KYT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

523844:MSTHT RS10800
gene id: 523844:MSTHT_RS10800
uniprot id: A0A0E3H9B2
names: Similarity
messages: Belongs to the UPF0107 family.

523844:MSTHT RS07205
gene id: 523844:MSTHT_RS07205
uniprot id: A0A0E3NC77
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS01150
gene id: 523844:MSTHT_RS01150
uniprot id: A0A0E3H894
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10895
gene id: 523844:MSTHT_RS10895
uniprot id: A0A0E3NE56
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

523844:MSTHT RS03055
gene id: 523844:MSTHT_RS03055
uniprot id: A0A0E3NB23
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

523844:MSTHT RS12075
gene id: 523844:MSTHT_RS12075
uniprot id: A0A0E3NEF6
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523844:MSTHT RS06585
gene id: 523844:MSTHT_RS06585
uniprot id: A0A0E3NBD2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

523844:MSTHT RS02600
gene id: 523844:MSTHT_RS02600
uniprot id: A0A0E3NAX8
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS08400
gene id: 523844:MSTHT_RS08400
uniprot id: A0A0E3KPU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523844:MSTHT RS10700
gene id: 523844:MSTHT_RS10700
uniprot id: A0A0E3NA48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS07480
gene id: 523844:MSTHT_RS07480
uniprot id: A0A0E3H8Y7
names: Similarity
messages: Belongs to the FrhG family.

523844:MSTHT RS06630
gene id: 523844:MSTHT_RS06630
uniprot id: A0A0E3H8V5
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS11455
gene id: 523844:MSTHT_RS11455
uniprot id: A0A0E3KQ65
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

523844:MSTHT RS06130
gene id: 523844:MSTHT_RS06130
uniprot id: A0A0E3ND17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

523844:MSTHT RS04485
gene id: 523844:MSTHT_RS04485
uniprot id: A0A0E3NCN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

523844:MSTHT RS00145
gene id: 523844:MSTHT_RS00145
uniprot id: A0A0E3H859
names: Similarity
messages: Belongs to the DMRL synthase family.

523844:MSTHT RS06120
gene id: 523844:MSTHT_RS06120
uniprot id: A0A0E3KPJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

523844:MSTHT RS01805
gene id: 523844:MSTHT_RS01805
uniprot id: A0A0E3NA47
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

523844:MSTHT RS13160
gene id: 523844:MSTHT_RS13160
uniprot id: A0A0E3NG39
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS08005
gene id: 523844:MSTHT_RS08005
uniprot id: A0A0E3N9D1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS00075
gene id: 523844:MSTHT_RS00075
uniprot id: A0A0E3KXV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS12325
gene id: 523844:MSTHT_RS12325
uniprot id: A0A0E3KQA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS08510
gene id: 523844:MSTHT_RS08510
uniprot id: A0A0E3NDI9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523844:MSTHT RS10370
gene id: 523844:MSTHT_RS10370
uniprot id: A0A0E3KQ26
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

523844:MSTHT RS09855
gene id: 523844:MSTHT_RS09855
uniprot id: A0A0E3N9W1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

523844:MSTHT RS05030
gene id: 523844:MSTHT_RS05030
uniprot id: A0A0E3NE21
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

523844:MSTHT RS07810
gene id: 523844:MSTHT_RS07810
uniprot id: A0A0E3H900
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523844:MSTHT RS07525
gene id: 523844:MSTHT_RS07525
uniprot id: A0A0E3NCA1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

523844:MSTHT RS05645
gene id: 523844:MSTHT_RS05645
uniprot id: A0A0E3H8R8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

523844:MSTHT RS00800
gene id: 523844:MSTHT_RS00800
uniprot id: A0A0E3N7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

523844:MSTHT RS12065
gene id: 523844:MSTHT_RS12065
uniprot id: A0A0E3KQ92
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523844:MSTHT RS02440
gene id: 523844:MSTHT_RS02440
uniprot id: A0A0E3NAW8
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS02725
gene id: 523844:MSTHT_RS02725
uniprot id: A0A0E3KNZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS01245
gene id: 523844:MSTHT_RS01245
uniprot id: A0A0E3KXZ4
names: Function
messages: Part of a potassium transport system.

523844:MSTHT RS09770
gene id: 523844:MSTHT_RS09770
uniprot id: A0A0E3NCD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

523844:MSTHT RS07530
gene id: 523844:MSTHT_RS07530
uniprot id: A0A0E3H8Y9
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

523844:MSTHT RS08385
gene id: 523844:MSTHT_RS08385
uniprot id: A0A0E3KYZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

523844:MSTHT RS00865
gene id: 523844:MSTHT_RS00865
uniprot id: A0A0E3NCW1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS04430
gene id: 523844:MSTHT_RS04430
uniprot id: A0A0E3NCM6
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

523844:MSTHT RS08695
gene id: 523844:MSTHT_RS08695
uniprot id: A0A0E3KPV8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

523844:MSTHT RS04165
gene id: 523844:MSTHT_RS04165
uniprot id: A0A0E3KP51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

523844:MSTHT RS12430
gene id: 523844:MSTHT_RS12430
uniprot id: A0A0E3NEI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

523844:MSTHT RS08490
gene id: 523844:MSTHT_RS08490
uniprot id: A0A0E3H927
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS13055
gene id: 523844:MSTHT_RS13055
uniprot id: A0A0E3H9J6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

523844:MSTHT RS05250
gene id: 523844:MSTHT_RS05250
uniprot id: A0A0E3KPE7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

523844:MSTHT RS10475
gene id: 523844:MSTHT_RS10475
uniprot id: A0A0E3KQ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523844:MSTHT RS05555
gene id: 523844:MSTHT_RS05555
uniprot id: A0A0E3KPG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

523844:MSTHT RS00140
gene id: 523844:MSTHT_RS00140
uniprot id: A0A0E3NBP0
names: Similarity
messages: Belongs to the DMRL synthase family.

523844:MSTHT RS01440
gene id: 523844:MSTHT_RS01440
uniprot id: A0A0E3KY04
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523844:MSTHT RS05990
gene id: 523844:MSTHT_RS05990
uniprot id: A0A0E3KPI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

523844:MSTHT RS13005
gene id: 523844:MSTHT_RS13005
uniprot id: A0A0E3H9J4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

523844:MSTHT RS01250
gene id: 523844:MSTHT_RS01250
uniprot id: A0A0E3H898
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

523844:MSTHT RS09025
gene id: 523844:MSTHT_RS09025
uniprot id: A0A0E3KPX0
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

523844:MSTHT RS11750
gene id: 523844:MSTHT_RS11750
uniprot id: A0A0E3H9E7
names: Similarity
messages: Belongs to the eIF-2-alpha family.

523844:MSTHT RS00105
gene id: 523844:MSTHT_RS00105
uniprot id: A0A0E3KXV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

523844:MSTHT RS12185
gene id: 523844:MSTHT_RS12185
uniprot id: A0A0E3NFV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS02730
gene id: 523844:MSTHT_RS02730
uniprot id: A0A0E3H8F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

523844:MSTHT RS12000
gene id: 523844:MSTHT_RS12000
uniprot id: A0A0E3NFT4
names: Similarity
messages: Belongs to the AAA ATPase family.

523844:MSTHT RS12710
gene id: 523844:MSTHT_RS12710
uniprot id: A0A0E3H9I2
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

523844:MSTHT RS05985
gene id: 523844:MSTHT_RS05985
uniprot id: A0A0E3NBW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS10025
gene id: 523844:MSTHT_RS10025
uniprot id: A0A0E3NCW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

523844:MSTHT RS07225
gene id: 523844:MSTHT_RS07225
uniprot id: A0A0E3KPP3
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS10835
gene id: 523844:MSTHT_RS10835
uniprot id: A0A0E3KQ43
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523844:MSTHT RS07360
gene id: 523844:MSTHT_RS07360
uniprot id: A0A0E3NBI0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

523844:MSTHT RS12490
gene id: 523844:MSTHT_RS12490
uniprot id: A0A0E3ND21
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523844:MSTHT RS04210
gene id: 523844:MSTHT_RS04210
uniprot id: A0A0E3NDT9
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

523844:MSTHT RS09525
gene id: 523844:MSTHT_RS09525
uniprot id: A0A0E3N9Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

523844:MSTHT RS08875
gene id: 523844:MSTHT_RS08875
uniprot id: A0A0E3NCJ8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523844:MSTHT RS13560
gene id: 523844:MSTHT_RS13560
uniprot id: A0A0E3NG68
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

523844:MSTHT RS03270
gene id: 523844:MSTHT_RS03270
uniprot id: A0A0E3N7V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

523844:MSTHT RS12420
gene id: 523844:MSTHT_RS12420
uniprot id: A0A0E3H9H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

523844:MSTHT RS10805
gene id: 523844:MSTHT_RS10805
uniprot id: A0A0E3KQ41
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS04145
gene id: 523844:MSTHT_RS04145
uniprot id: A0A0E3H8L0
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

523844:MSTHT RS04880
gene id: 523844:MSTHT_RS04880
uniprot id: A0A0E3H8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS07245
gene id: 523844:MSTHT_RS07245
uniprot id: A0A0E3H8X8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS03220
gene id: 523844:MSTHT_RS03220
uniprot id: A0A0E3H8H5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

523844:MSTHT RS13515
gene id: 523844:MSTHT_RS13515
uniprot id: A0A0E3KQI1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523844:MSTHT RS06560
gene id: 523844:MSTHT_RS06560
uniprot id: A0A0E3NEG4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523844:MSTHT RS00415
gene id: 523844:MSTHT_RS00415
uniprot id: A0A0E3NCS7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

523844:MSTHT RS04525
gene id: 523844:MSTHT_RS04525
uniprot id: A0A0E3NDX8
names: Cofactor
messages: Binds 1 copper ion per subunit.

523844:MSTHT RS01345
gene id: 523844:MSTHT_RS01345
uniprot id: A0A0E3NA00
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS08330
gene id: 523844:MSTHT_RS08330
uniprot id: A0A0E3N9F8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523844:MSTHT RS03490
gene id: 523844:MSTHT_RS03490
uniprot id: A0A0E3KP23
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

523844:MSTHT RS07350
gene id: 523844:MSTHT_RS07350
uniprot id: A0A0E3H8Y2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

523844:MSTHT RS04340
gene id: 523844:MSTHT_RS04340
uniprot id: A0A0E3KYG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

523844:MSTHT RS02305
gene id: 523844:MSTHT_RS02305
uniprot id: A0A0E3KNX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

523844:MSTHT RS11055
gene id: 523844:MSTHT_RS11055
uniprot id: A0A0E3NA73
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

523844:MSTHT RS05330
gene id: 523844:MSTHT_RS05330
uniprot id: A0A0E3H8Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS01695
gene id: 523844:MSTHT_RS01695
uniprot id: A0A0E3NA34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS04080
gene id: 523844:MSTHT_RS04080
uniprot id: A0A0E3NAR3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523844:MSTHT RS08640
gene id: 523844:MSTHT_RS08640
uniprot id: A0A0E3NC21
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523844:MSTHT RS10610
gene id: 523844:MSTHT_RS10610
uniprot id: A0A0E3KQ34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523844:MSTHT RS09195
gene id: 523844:MSTHT_RS09195
uniprot id: A0A0E3NCM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

523844:MSTHT RS11170
gene id: 523844:MSTHT_RS11170
uniprot id: A0A0E3NFK9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523844:MSTHT RS07375
gene id: 523844:MSTHT_RS07375
uniprot id: A0A0E3H8Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

523844:MSTHT RS06185
gene id: 523844:MSTHT_RS06185
uniprot id: A0A0E3KPJ9
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

523844:MSTHT RS06550
gene id: 523844:MSTHT_RS06550
uniprot id: A0A0E3H8V2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS12085
gene id: 523844:MSTHT_RS12085
uniprot id: A0A0E3KZB9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

523844:MSTHT RS10660
gene id: 523844:MSTHT_RS10660
uniprot id: A0A0E3KZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

523844:MSTHT RS12485
gene id: 523844:MSTHT_RS12485
uniprot id: A0A0E3NEI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523844:MSTHT RS10670
gene id: 523844:MSTHT_RS10670
uniprot id: A0A0E3H9A7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

523844:MSTHT RS06090
gene id: 523844:MSTHT_RS06090
uniprot id: A0A0E3KPJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS05090
gene id: 523844:MSTHT_RS05090
uniprot id: A0A0E3NE29
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

523844:MSTHT RS13405
gene id: 523844:MSTHT_RS13405
uniprot id: A0A0E3KZI5
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

523844:MSTHT RS03765
gene id: 523844:MSTHT_RS03765
uniprot id: A0A0E3N7Z6
names: Similarity
messages: Belongs to the oxoprolinase family.

523844:MSTHT RS10315
gene id: 523844:MSTHT_RS10315
uniprot id: A0A0E3NA08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523844:MSTHT RS03895
gene id: 523844:MSTHT_RS03895
uniprot id: A0A0E3NCF1
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS04650
gene id: 523844:MSTHT_RS04650
uniprot id: A0A0E3H8N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

523844:MSTHT RS12840
gene id: 523844:MSTHT_RS12840
uniprot id: A0A0E3NAQ4
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

523844:MSTHT RS12415
gene id: 523844:MSTHT_RS12415
uniprot id: A0A0E3KQB2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

523844:MSTHT RS11410
gene id: 523844:MSTHT_RS11410
uniprot id: A0A0E3H9D4
names: Similarity
messages: Belongs to the LarC family.

523844:MSTHT RS08335
gene id: 523844:MSTHT_RS08335
uniprot id: A0A0E3KPU4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523844:MSTHT RS01140
gene id: 523844:MSTHT_RS01140
uniprot id: A0A0E3N7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

523844:MSTHT RS01880
gene id: 523844:MSTHT_RS01880
uniprot id: A0A0E3H8C3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

523844:MSTHT RS12390
gene id: 523844:MSTHT_RS12390
uniprot id: A0A0E3ND15
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523844:MSTHT RS01025
gene id: 523844:MSTHT_RS01025
uniprot id: A0A0E3N7C1
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

523844:MSTHT RS03975
gene id: 523844:MSTHT_RS03975
uniprot id: A0A0E3KP42
names: Function
names: Subcellular Location Annotation
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

523844:MSTHT RS12265
gene id: 523844:MSTHT_RS12265
uniprot id: A0A0E3KZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

523844:MSTHT RS08625
gene id: 523844:MSTHT_RS08625
uniprot id: A0A0E3NDK1
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

523844:MSTHT RS06035
gene id: 523844:MSTHT_RS06035
uniprot id: A0A0E3NB95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523844:MSTHT RS01935
gene id: 523844:MSTHT_RS01935
uniprot id: A0A0E3H8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523844:MSTHT RS05905
gene id: 523844:MSTHT_RS05905
uniprot id: A0A0E3H8S8
names: Similarity
messages: Belongs to the HypD family.

523844:MSTHT RS02365
gene id: 523844:MSTHT_RS02365
uniprot id: A0A0E3ND87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

523844:MSTHT RS07840
gene id: 523844:MSTHT_RS07840
uniprot id: A0A0E3NBQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

523844:MSTHT RS02375
gene id: 523844:MSTHT_RS02375
uniprot id: A0A0E3KNX2
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS07040
gene id: 523844:MSTHT_RS07040
uniprot id: A0A0E3KYU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

523844:MSTHT RS03915
gene id: 523844:MSTHT_RS03915
uniprot id: A0A0E3NAP3
names: Similarity
messages: Belongs to the CutA family.

523844:MSTHT RS13490
gene id: 523844:MSTHT_RS13490
uniprot id: A0A0E3NG64
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523844:MSTHT RS08420
gene id: 523844:MSTHT_RS08420
uniprot id: A0A0E3KYZ7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

523844:MSTHT RS12815
gene id: 523844:MSTHT_RS12815
uniprot id: A0A0E3ND52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

523844:MSTHT RS09205
gene id: 523844:MSTHT_RS09205
uniprot id: A0A0E3H954
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523844:MSTHT RS07980
gene id: 523844:MSTHT_RS07980
uniprot id: A0A0E3KPS3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

523844:MSTHT RS12300
gene id: 523844:MSTHT_RS12300
uniprot id: A0A0E3NFV8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

523844:MSTHT RS09620
gene id: 523844:MSTHT_RS09620
uniprot id: A0A0E3KZ36
names: Similarity
messages: Belongs to the UPF0200 family.

523844:MSTHT RS12460
gene id: 523844:MSTHT_RS12460
uniprot id: A0A0E3NAL6
names: Similarity
messages: Belongs to the UPF0285 family.

523844:MSTHT RS00125
gene id: 523844:MSTHT_RS00125
uniprot id: A0A0E3N766
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523844:MSTHT RS02325
gene id: 523844:MSTHT_RS02325
uniprot id: A0A0E3NC19
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

523844:MSTHT RS13480
gene id: 523844:MSTHT_RS13480
uniprot id: A0A0E3KQH8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523844:MSTHT RS02980
gene id: 523844:MSTHT_RS02980
uniprot id: A0A0E3NC73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523844:MSTHT RS04845
gene id: 523844:MSTHT_RS04845
uniprot id: A0A0E3NBP6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

523844:MSTHT RS01705
gene id: 523844:MSTHT_RS01705
uniprot id: A0A0E3H8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

523844:MSTHT RS09615
gene id: 523844:MSTHT_RS09615
uniprot id: A0A0E3NCB5
names: Similarity
messages: Belongs to the UPF0201 family.

523844:MSTHT RS07510
gene id: 523844:MSTHT_RS07510
uniprot id: A0A0E3H8Y8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

523844:MSTHT RS00815
gene id: 523844:MSTHT_RS00815
uniprot id: A0A0E3NBS5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

523844:MSTHT RS04655
gene id: 523844:MSTHT_RS04655
uniprot id: A0A0E3NAY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

523844:MSTHT RS08940
gene id: 523844:MSTHT_RS08940
uniprot id: A0A0E3NF21
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523844:MSTHT RS07685
gene id: 523844:MSTHT_RS07685
uniprot id: A0A0E3NCB3
names: Subcellular Location Annotation
messages: Membrane

523844:MSTHT RS03670
gene id: 523844:MSTHT_RS03670
uniprot id: A0A0E3KYC4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane