523841:E6P09 RS00455
gene id: 523841:E6P09_RS00455
uniprot id: I3R6S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523841:E6P09 RS01070
gene id: 523841:E6P09_RS01070
uniprot id: M0IUN7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523841:E6P09 RS11225
gene id: 523841:E6P09_RS11225
uniprot id: I3R533
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS05110
gene id: 523841:E6P09_RS05110
uniprot id: M0J2P0
names: Similarity
messages: Belongs to the UPF0215 family.

523841:E6P09 RS02940
gene id: 523841:E6P09_RS02940
uniprot id: I3R8V5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

523841:E6P09 RS15530
gene id: 523841:E6P09_RS15530
uniprot id: I3RA69
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS14600
gene id: 523841:E6P09_RS14600
uniprot id: I3R7B4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS14180
gene id: 523841:E6P09_RS14180
uniprot id: I3R7I7
names: Similarity
messages: Belongs to the HypE family.

523841:E6P09 RS00845
gene id: 523841:E6P09_RS00845
uniprot id: I3R6J7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS04770
gene id: 523841:E6P09_RS04770
uniprot id: I3R1G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS06500
gene id: 523841:E6P09_RS06500
uniprot id: I3R2F4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS13880
gene id: 523841:E6P09_RS13880
uniprot id: I3R7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523841:E6P09 RS13920
gene id: 523841:E6P09_RS13920
uniprot id: I3R7P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

523841:E6P09 RS07910
gene id: 523841:E6P09_RS07910
uniprot id: M0J520
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS02405
gene id: 523841:E6P09_RS02405
uniprot id: I3R5P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS03140
gene id: 523841:E6P09_RS03140
uniprot id: I3R0J4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523841:E6P09 RS05930
gene id: 523841:E6P09_RS05930
uniprot id: I3R242
names: Similarity
messages: Belongs to the UPF0284 family.

523841:E6P09 RS00775
gene id: 523841:E6P09_RS00775
uniprot id: I3R6L2
names: Subunit
messages: Homotrimer.

523841:E6P09 RS03435
gene id: 523841:E6P09_RS03435
uniprot id: I3R0Q1
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS03340
gene id: 523841:E6P09_RS03340
uniprot id: I3R0N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

523841:E6P09 RS09115
gene id: 523841:E6P09_RS09115
uniprot id: I3R3X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523841:E6P09 RS10700
gene id: 523841:E6P09_RS10700
uniprot id: I3R4S9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

523841:E6P09 RS08355
gene id: 523841:E6P09_RS08355
uniprot id: I3R3H1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS13675
gene id: 523841:E6P09_RS13675
uniprot id: I3R7T8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04885
gene id: 523841:E6P09_RS04885
uniprot id: I3R1I8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS19320
gene id: 523841:E6P09_RS19320
uniprot id: I3R975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

523841:E6P09 RS02740
gene id: 523841:E6P09_RS02740
uniprot id: I3R8R5
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

523841:E6P09 RS08540
gene id: 523841:E6P09_RS08540
uniprot id: I3R3K9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS06365
gene id: 523841:E6P09_RS06365
uniprot id: I3R2C8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS01380
gene id: 523841:E6P09_RS01380
uniprot id: I3R696
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

523841:E6P09 RS05080
gene id: 523841:E6P09_RS05080
uniprot id: I3R1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

523841:E6P09 RS10985
gene id: 523841:E6P09_RS10985
uniprot id: I3R4Y7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15290
gene id: 523841:E6P09_RS15290
uniprot id: I3RAB8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

523841:E6P09 RS05880
gene id: 523841:E6P09_RS05880
uniprot id: I3R230
names: Similarity
messages: Belongs to the ComB family.

523841:E6P09 RS03030
gene id: 523841:E6P09_RS03030
uniprot id: I3R8X3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS12495
gene id: 523841:E6P09_RS12495
uniprot id: I3R8G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

523841:E6P09 RS06760
gene id: 523841:E6P09_RS06760
uniprot id: I3R2K9
names: Similarity
messages: Belongs to the TrpC family.

523841:E6P09 RS04595
gene id: 523841:E6P09_RS04595
uniprot id: I3R1D0
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523841:E6P09 RS18345
gene id: 523841:E6P09_RS18345
uniprot id: I3RA68
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13875
gene id: 523841:E6P09_RS13875
uniprot id: I3R7Q2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

523841:E6P09 RS05215
gene id: 523841:E6P09_RS05215
uniprot id: I3R1Q4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12975
gene id: 523841:E6P09_RS12975
uniprot id: I3R877
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

523841:E6P09 RS13910
gene id: 523841:E6P09_RS13910
uniprot id: I3R7P5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS11910
gene id: 523841:E6P09_RS11910
uniprot id: I3R5H0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS18420
gene id: 523841:E6P09_RS18420
uniprot id: I3R9E2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11680
gene id: 523841:E6P09_RS11680
uniprot id: I3R5C7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08095
gene id: 523841:E6P09_RS08095
uniprot id: I3R3B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

523841:E6P09 RS04215
gene id: 523841:E6P09_RS04215
uniprot id: I3R152
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523841:E6P09 RS13795
gene id: 523841:E6P09_RS13795
uniprot id: I3R7R5
names: Similarity
messages: Belongs to the group II decarboxylase family.

523841:E6P09 RS17380
gene id: 523841:E6P09_RS17380
uniprot id: I3R9L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm

523841:E6P09 RS12810
gene id: 523841:E6P09_RS12810
uniprot id: I3R8A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

523841:E6P09 RS13860
gene id: 523841:E6P09_RS13860
uniprot id: I3R7Q5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

523841:E6P09 RS11840
gene id: 523841:E6P09_RS11840
uniprot id: I3R5F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

523841:E6P09 RS06875
gene id: 523841:E6P09_RS06875
uniprot id: I3R2N2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00740
gene id: 523841:E6P09_RS00740
uniprot id: I3R6L9
names: Cofactor
messages: Binds 1 copper ion per subunit.

523841:E6P09 RS08340
gene id: 523841:E6P09_RS08340
uniprot id: I3R3G7
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS09795
gene id: 523841:E6P09_RS09795
uniprot id: I3R4A5
names: Similarity
messages: Belongs to the UPF0173 family.

523841:E6P09 RS11805
gene id: 523841:E6P09_RS11805
uniprot id: I3R5F1
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.

523841:E6P09 RS14710
gene id: 523841:E6P09_RS14710
uniprot id: I3R792
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523841:E6P09 RS14595
gene id: 523841:E6P09_RS14595
uniprot id: I3R7B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06305
gene id: 523841:E6P09_RS06305
uniprot id: I3R2B5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

523841:E6P09 RS04775
gene id: 523841:E6P09_RS04775
uniprot id: I3R1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

523841:E6P09 RS18500
gene id: 523841:E6P09_RS18500
uniprot id: I3R9G2
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS03285
gene id: 523841:E6P09_RS03285
uniprot id: I3R0M2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03420
gene id: 523841:E6P09_RS03420
uniprot id: I3R0P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523841:E6P09 RS07820
gene id: 523841:E6P09_RS07820
uniprot id: I3R363
names: Similarity
messages: Belongs to the peptidase S9C family.

523841:E6P09 RS07925
gene id: 523841:E6P09_RS07925
uniprot id: I3R384
names: Similarity
messages: Belongs to the complex I subunit 3 family.

523841:E6P09 RS06830
gene id: 523841:E6P09_RS06830
uniprot id: I3R2M3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

523841:E6P09 RS12860
gene id: 523841:E6P09_RS12860
uniprot id: I3R899
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

523841:E6P09 RS17885
gene id: 523841:E6P09_RS17885
uniprot id: I3R9X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05720
gene id: 523841:E6P09_RS05720
uniprot id: I3R200
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523841:E6P09 RS18585
gene id: 523841:E6P09_RS18585
uniprot id: I3R9H8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

523841:E6P09 RS10625
gene id: 523841:E6P09_RS10625
uniprot id: I3R4R5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523841:E6P09 RS13235
gene id: 523841:E6P09_RS13235
uniprot id: I3R828
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

523841:E6P09 RS03240
gene id: 523841:E6P09_RS03240
uniprot id: I3R0L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS07035
gene id: 523841:E6P09_RS07035
uniprot id: I3R2R3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

523841:E6P09 RS01625
gene id: 523841:E6P09_RS01625
uniprot id: I3R646
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

523841:E6P09 RS17720
gene id: 523841:E6P09_RS17720
uniprot id: I3R9U1
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

523841:E6P09 RS01955
gene id: 523841:E6P09_RS01955
uniprot id: I3R5Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS10640
gene id: 523841:E6P09_RS10640
uniprot id: I3R4R8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13850
gene id: 523841:E6P09_RS13850
uniprot id: I3R7Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

523841:E6P09 RS13755
gene id: 523841:E6P09_RS13755
uniprot id: I3R7S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

523841:E6P09 RS08655
gene id: 523841:E6P09_RS08655
uniprot id: I3R3N3
names: Cofactor
messages: The crystal structure with reduced Cu(1+) has also been determined.

523841:E6P09 RS12075
gene id: 523841:E6P09_RS12075
uniprot id: I3R5K4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS14375
gene id: 523841:E6P09_RS14375
uniprot id: I3R7F4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

523841:E6P09 RS13865
gene id: 523841:E6P09_RS13865
uniprot id: I3R7Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

523841:E6P09 RS08410
gene id: 523841:E6P09_RS08410
uniprot id: I3R3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS03670
gene id: 523841:E6P09_RS03670
uniprot id: I3R0U9
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS04815
gene id: 523841:E6P09_RS04815
uniprot id: I3R1H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS06060
gene id: 523841:E6P09_RS06060
uniprot id: A0A059TRL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04765
gene id: 523841:E6P09_RS04765
uniprot id: M0J0K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS13935
gene id: 523841:E6P09_RS13935
uniprot id: M0IQX1
uniprot id: P50561
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

523841:E6P09 RS08480
gene id: 523841:E6P09_RS08480
uniprot id: M0J6I5
uniprot id: Q977U7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activated by molar concentrations of KCl or NaCl. Inhibited by EDTA in vitro.
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Binds 2 Zn(2+) ions per subunit. One of the zinc atoms is essential for catalytic activity while the other has a structural function, according to Ref.4. However, the crystal structures show a single zinc ion, the catalytic one.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-xylose, D-galactose, and D-fucose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a preference for NADP(+). Physiologically, seems to be involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction follows an ordered Bi-Bi kinetic mechanism, involving an ordered binding of NADP(+) and D-glucose, followed by an ordered released of gluconolactone and NADPH.
messages: Up-regulated by glucose.

523841:E6P09 RS14855
gene id: 523841:E6P09_RS14855
uniprot id: I3R763
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

523841:E6P09 RS07875
gene id: 523841:E6P09_RS07875
uniprot id: I3R374
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

523841:E6P09 RS08345
gene id: 523841:E6P09_RS08345
uniprot id: I3R3G8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS05445
gene id: 523841:E6P09_RS05445
uniprot id: M0J090
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

523841:E6P09 RS08380
gene id: 523841:E6P09_RS08380
uniprot id: I3R3H6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS00460
gene id: 523841:E6P09_RS00460
uniprot id: I3R6S4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523841:E6P09 RS07965
gene id: 523841:E6P09_RS07965
uniprot id: I3R392
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS18195
gene id: 523841:E6P09_RS18195
uniprot id: I3RA39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18675
gene id: 523841:E6P09_RS18675
uniprot id: I3R9J6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS17205
gene id: 523841:E6P09_RS17205
uniprot id: I3RAJ2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523841:E6P09 RS14160
gene id: 523841:E6P09_RS14160
uniprot id: I3R7J1
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

523841:E6P09 RS18450
gene id: 523841:E6P09_RS18450
uniprot id: I3R9F2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS12385
gene id: 523841:E6P09_RS12385
uniprot id: I3R8J0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS17565
gene id: 523841:E6P09_RS17565
uniprot id: I3R9Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

523841:E6P09 RS08185
gene id: 523841:E6P09_RS08185
uniprot id: I3R3D5
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS06555
gene id: 523841:E6P09_RS06555
uniprot id: I3R2G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

523841:E6P09 RS12980
gene id: 523841:E6P09_RS12980
uniprot id: I3R876
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

523841:E6P09 RS03005
gene id: 523841:E6P09_RS03005
uniprot id: I3R8W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

523841:E6P09 RS17715
gene id: 523841:E6P09_RS17715
uniprot id: I3R9U0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04325
gene id: 523841:E6P09_RS04325
uniprot id: I3R176
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 12-fold increase in the presence of 2-oxoglutarate. Up to 18-fold increase in the presence of 2-oxoglutarate and GlnK1 or GlnK2. Inhibited by AMP and glutamine.
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homododecamer (PubMed:23069245). Interacts with the nitrogen regulatory proteins GlnK1 and GlnK2 in the presence of 2-oxoglutarate (PubMed:23069245).
messages: Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

523841:E6P09 RS09270
gene id: 523841:E6P09_RS09270
uniprot id: I3R405
names: Similarity
messages: Belongs to the glutaredoxin family.

523841:E6P09 RS00375
gene id: 523841:E6P09_RS00375
uniprot id: I3R6U2
names: Similarity
messages: Belongs to the thymidylate kinase family.

523841:E6P09 RS18665
gene id: 523841:E6P09_RS18665
uniprot id: I3R9J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

523841:E6P09 RS16095
gene id: 523841:E6P09_RS16095
uniprot id: I3RB81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18280
gene id: 523841:E6P09_RS18280
uniprot id: I3RA55
names: Subunit
messages: Homodimer.

523841:E6P09 RS07345
gene id: 523841:E6P09_RS07345
uniprot id: I3R2X5
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15395
gene id: 523841:E6P09_RS15395
uniprot id: I3RA99
names: Similarity
messages: Belongs to the TPP enzyme family.

523841:E6P09 RS15975
gene id: 523841:E6P09_RS15975
uniprot id: I3RBA5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523841:E6P09 RS08090
gene id: 523841:E6P09_RS08090
uniprot id: I3R3B8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523841:E6P09 RS09085
gene id: 523841:E6P09_RS09085
uniprot id: I3R3W7
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

523841:E6P09 RS12770
gene id: 523841:E6P09_RS12770
uniprot id: I3R8B5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS10875
gene id: 523841:E6P09_RS10875
uniprot id: M0J6F9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

523841:E6P09 RS03300
gene id: 523841:E6P09_RS03300
uniprot id: I3R0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

523841:E6P09 RS07170
gene id: 523841:E6P09_RS07170
uniprot id: I3R2U0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

523841:E6P09 RS02630
gene id: 523841:E6P09_RS02630
uniprot id: I3R8P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523841:E6P09 RS14860
gene id: 523841:E6P09_RS14860
uniprot id: M0IVX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06825
gene id: 523841:E6P09_RS06825
uniprot id: I3R2M2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04635
gene id: 523841:E6P09_RS04635
uniprot id: I3R1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523841:E6P09 RS10825
gene id: 523841:E6P09_RS10825
uniprot id: I3R4V5
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.

523841:E6P09 RS02060
gene id: 523841:E6P09_RS02060
uniprot id: I3R5W2
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

523841:E6P09 RS08475
gene id: 523841:E6P09_RS08475
uniprot id: I3R3J5
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

523841:E6P09 RS11885
gene id: 523841:E6P09_RS11885
uniprot id: I3R5G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523841:E6P09 RS03575
gene id: 523841:E6P09_RS03575
uniprot id: I3R0S8
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

523841:E6P09 RS14830
gene id: 523841:E6P09_RS14830
uniprot id: I3R768
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

523841:E6P09 RS18655
gene id: 523841:E6P09_RS18655
uniprot id: I3R9J2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523841:E6P09 RS13165
gene id: 523841:E6P09_RS13165
uniprot id: I3R840
names: Similarity
messages: Belongs to the archease family.

523841:E6P09 RS05155
gene id: 523841:E6P09_RS05155
uniprot id: I3R1P3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08110
gene id: 523841:E6P09_RS08110
uniprot id: M0J4X5
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

523841:E6P09 RS03480
gene id: 523841:E6P09_RS03480
uniprot id: I3R0Q9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

523841:E6P09 RS15055
gene id: 523841:E6P09_RS15055
uniprot id: M0IS95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

523841:E6P09 RS13030
gene id: 523841:E6P09_RS13030
uniprot id: I3R866
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

523841:E6P09 RS06030
gene id: 523841:E6P09_RS06030
uniprot id: I3R263
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06280
gene id: 523841:E6P09_RS06280
uniprot id: I3R2B0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

523841:E6P09 RS00970
gene id: 523841:E6P09_RS00970
uniprot id: A0A4P8P1H3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523841:E6P09 RS01205
gene id: 523841:E6P09_RS01205
uniprot id: I3R6C8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

523841:E6P09 RS16970
gene id: 523841:E6P09_RS16970
uniprot id: I3RAN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS00290
gene id: 523841:E6P09_RS00290
uniprot id: I3R6V6
names: Similarity
messages: Belongs to the Ahb/Nir family.

523841:E6P09 RS01985
gene id: 523841:E6P09_RS01985
uniprot id: I3R5X9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

523841:E6P09 RS05150
gene id: 523841:E6P09_RS05150
uniprot id: I3R1P2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS18480
gene id: 523841:E6P09_RS18480
uniprot id: I3R9F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS13350
gene id: 523841:E6P09_RS13350
uniprot id: I3R803
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

523841:E6P09 RS03055
gene id: 523841:E6P09_RS03055
uniprot id: A0A059TMH9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS18535
gene id: 523841:E6P09_RS18535
uniprot id: I3R9G8
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

523841:E6P09 RS12415
gene id: 523841:E6P09_RS12415
uniprot id: I3R8I4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

523841:E6P09 RS19090
gene id: 523841:E6P09_RS19090
uniprot id: I3R932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11210
gene id: 523841:E6P09_RS11210
uniprot id: I3R530
names: Similarity
messages: Belongs to the arginase family.

523841:E6P09 RS13775
gene id: 523841:E6P09_RS13775
uniprot id: I3R7R9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

523841:E6P09 RS05785
gene id: 523841:E6P09_RS05785
uniprot id: I3R213
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523841:E6P09 RS14870
gene id: 523841:E6P09_RS14870
uniprot id: I3R760
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

523841:E6P09 RS06725
gene id: 523841:E6P09_RS06725
uniprot id: I3R2K2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS16205
gene id: 523841:E6P09_RS16205
uniprot id: I3RB54
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08195
gene id: 523841:E6P09_RS08195
uniprot id: I3R3D7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03145
gene id: 523841:E6P09_RS03145
uniprot id: I3R0J5
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

523841:E6P09 RS13960
gene id: 523841:E6P09_RS13960
uniprot id: I3R7N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08050
gene id: 523841:E6P09_RS08050
uniprot id: I3R3B0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS09250
gene id: 523841:E6P09_RS09250
uniprot id: I3R401
names: Similarity
messages: Belongs to the SCO1/2 family.

523841:E6P09 RS07115
gene id: 523841:E6P09_RS07115
uniprot id: I3R2S9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

523841:E6P09 RS17955
gene id: 523841:E6P09_RS17955
uniprot id: I3R9Y6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12295
gene id: 523841:E6P09_RS12295
uniprot id: I3R8K8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

523841:E6P09 RS01285
gene id: 523841:E6P09_RS01285
uniprot id: I3R6B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

523841:E6P09 RS03130
gene id: 523841:E6P09_RS03130
uniprot id: I3R0J2
names: Similarity
messages: Belongs to the aspartokinase family.

523841:E6P09 RS00980
gene id: 523841:E6P09_RS00980
uniprot id: I3R6H2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS10660
gene id: 523841:E6P09_RS10660
uniprot id: I3R4S2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

523841:E6P09 RS04945
gene id: 523841:E6P09_RS04945
uniprot id: I3R1K0
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

523841:E6P09 RS13100
gene id: 523841:E6P09_RS13100
uniprot id: I3R851
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS08690
gene id: 523841:E6P09_RS08690
uniprot id: I3R3P0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

523841:E6P09 RS02115
gene id: 523841:E6P09_RS02115
uniprot id: A0A059TWI9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18985
gene id: 523841:E6P09_RS18985
uniprot id: M0IP42
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

523841:E6P09 RS02850
gene id: 523841:E6P09_RS02850
uniprot id: I3R8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

523841:E6P09 RS16725
gene id: 523841:E6P09_RS16725
uniprot id: I3RAU3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523841:E6P09 RS15130
gene id: 523841:E6P09_RS15130
uniprot id: I3RAF0
names: Subcellular Location Annotation
messages: Cell membrane

523841:E6P09 RS03100
gene id: 523841:E6P09_RS03100
uniprot id: I3R0I6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS16085
gene id: 523841:E6P09_RS16085
uniprot id: I3RB83
names: Similarity
messages: Belongs to the thioesterase PaaI family.

523841:E6P09 RS03770
gene id: 523841:E6P09_RS03770
uniprot id: I3R0W9
names: Similarity
messages: Belongs to the UPF0201 family.

523841:E6P09 RS07885
gene id: 523841:E6P09_RS07885
uniprot id: I3R376
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS02620
gene id: 523841:E6P09_RS02620
uniprot id: I3R8P2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

523841:E6P09 RS07650
gene id: 523841:E6P09_RS07650
uniprot id: I3R331
names: Similarity
messages: Belongs to the MCM family.

523841:E6P09 RS05670
gene id: 523841:E6P09_RS05670
uniprot id: I3R1Z1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

523841:E6P09 RS04625
gene id: 523841:E6P09_RS04625
uniprot id: I3R1D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

523841:E6P09 RS06720
gene id: 523841:E6P09_RS06720
uniprot id: A0A4P8P7U9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523841:E6P09 RS11015
gene id: 523841:E6P09_RS11015
uniprot id: I3R4Z2
names: Similarity
messages: Belongs to the CutA family.

523841:E6P09 RS14035
gene id: 523841:E6P09_RS14035
uniprot id: I3R7M0
names: Subcellular Location Annotation
messages: Cell membrane

523841:E6P09 RS15490
gene id: 523841:E6P09_RS15490
uniprot id: I3RA77
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14995
gene id: 523841:E6P09_RS14995
uniprot id: I3R734
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

523841:E6P09 RS18210
gene id: 523841:E6P09_RS18210
uniprot id: I3RA42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04450
gene id: 523841:E6P09_RS04450
uniprot id: I3R1A2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04755
gene id: 523841:E6P09_RS04755
uniprot id: I3R1G0
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS10050
gene id: 523841:E6P09_RS10050
uniprot id: I3R4F5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523841:E6P09 RS11735
gene id: 523841:E6P09_RS11735
uniprot id: I3R5D6
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

523841:E6P09 RS01580
gene id: 523841:E6P09_RS01580
uniprot id: I3R655
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

523841:E6P09 RS05610
gene id: 523841:E6P09_RS05610
uniprot id: I3R1Y0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

523841:E6P09 RS09420
gene id: 523841:E6P09_RS09420
uniprot id: I3R435
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

523841:E6P09 RS03825
gene id: 523841:E6P09_RS03825
uniprot id: I3R0X7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

523841:E6P09 RS01325
gene id: 523841:E6P09_RS01325
uniprot id: I3R6A7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

523841:E6P09 RS12615
gene id: 523841:E6P09_RS12615
uniprot id: I3R8E3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11450
gene id: 523841:E6P09_RS11450
uniprot id: I3R582
names: Similarity
messages: Belongs to the glutamine synthetase family.

523841:E6P09 RS18520
gene id: 523841:E6P09_RS18520
uniprot id: I3R9G5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

523841:E6P09 RS05210
gene id: 523841:E6P09_RS05210
uniprot id: I3R1Q3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS07930
gene id: 523841:E6P09_RS07930
uniprot id: I3R385
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

523841:E6P09 RS08015
gene id: 523841:E6P09_RS08015
uniprot id: I3R3A3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS16360
gene id: 523841:E6P09_RS16360
uniprot id: I3RB24
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523841:E6P09 RS12915
gene id: 523841:E6P09_RS12915
uniprot id: I3R889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS02480
gene id: 523841:E6P09_RS02480
uniprot id: M0ISZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523841:E6P09 RS04730
gene id: 523841:E6P09_RS04730
uniprot id: I3R1F7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

523841:E6P09 RS06815
gene id: 523841:E6P09_RS06815
uniprot id: I3R2M0
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

523841:E6P09 RS15505
gene id: 523841:E6P09_RS15505
uniprot id: I3RA74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05760
gene id: 523841:E6P09_RS05760
uniprot id: I3R208
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

523841:E6P09 RS06155
gene id: 523841:E6P09_RS06155
uniprot id: I3R287
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523841:E6P09 RS14280
gene id: 523841:E6P09_RS14280
uniprot id: I3R7H2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03195
gene id: 523841:E6P09_RS03195
uniprot id: I3R0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS12990
gene id: 523841:E6P09_RS12990
uniprot id: I3R874
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

523841:E6P09 RS10990
gene id: 523841:E6P09_RS10990
uniprot id: I3R4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

523841:E6P09 RS17435
gene id: 523841:E6P09_RS17435
uniprot id: I3R9M7
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.
messages: The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. May transfer electrons to the iron-sulfur centers of the catalytic beta subunit.

523841:E6P09 RS04350
gene id: 523841:E6P09_RS04350
uniprot id: I3R180
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08620
gene id: 523841:E6P09_RS08620
uniprot id: I3R3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523841:E6P09 RS07210
gene id: 523841:E6P09_RS07210
uniprot id: I3R2U8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS07245
gene id: 523841:E6P09_RS07245
uniprot id: I3R2V5
names: Similarity
messages: Belongs to the glutamate synthase family.

523841:E6P09 RS16195
gene id: 523841:E6P09_RS16195
uniprot id: I3RB57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

523841:E6P09 RS05145
gene id: 523841:E6P09_RS05145
uniprot id: I3R1P1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS12035
gene id: 523841:E6P09_RS12035
uniprot id: M0J587
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523841:E6P09 RS18395
gene id: 523841:E6P09_RS18395
uniprot id: I3R9D8
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

523841:E6P09 RS03120
gene id: 523841:E6P09_RS03120
uniprot id: I3R0J0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14885
gene id: 523841:E6P09_RS14885
uniprot id: I3R757
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS18605
gene id: 523841:E6P09_RS18605
uniprot id: I3R9I2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

523841:E6P09 RS07185
gene id: 523841:E6P09_RS07185
uniprot id: I3R2U3
names: Similarity
messages: Belongs to the DtxR/MntR family.

523841:E6P09 RS11510
gene id: 523841:E6P09_RS11510
uniprot id: Q02230
names: Activity Regulation
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Interacts with GvpD, also with c-GvpD from H.salinarum.
messages: Plays a regulatory role in gas vesicle synthesis, activates transcription of the gvpA operon, and probably of the gvpD operon (Probable) (PubMed:12864859). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: The amount of protein that accumulates is controlled by GvpD; GvpD causes a reduction in the amount of GvpE, preventing accumulation of excessive amounts of gas vesicles.
messages: Transcribed from mid-log to stationary phase, probably as a gvpD-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt at 15% salt (PubMed:8757736). Accumulates in late exponential to stationary phase (at protein level) (PubMed:12864859).

523841:E6P09 RS04025
gene id: 523841:E6P09_RS04025
uniprot id: I3R115
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS19145
gene id: 523841:E6P09_RS19145
uniprot id: I3R943
names: Similarity
messages: Belongs to the peptidase S33 family.

523841:E6P09 RS09770
gene id: 523841:E6P09_RS09770
uniprot id: I3R4A1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

523841:E6P09 RS13565
gene id: 523841:E6P09_RS13565
uniprot id: I3R7W0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523841:E6P09 RS17850
gene id: 523841:E6P09_RS17850
uniprot id: I3R9W4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

523841:E6P09 RS11490
gene id: 523841:E6P09_RS11490
uniprot id: M0J616
uniprot id: Q02239
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An ATPase that functions in gas vesicle formation (By similarity). A minor component of the gas vesicle, also found in soluble extracts (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: Cytoplasm
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Forms homodimers, a GvpN-GvpO heterodimer, interacts with GvpC and GvpL, might interact with GvpA.
messages: Gas vesicle
messages: Vesicle

523841:E6P09 RS18040
gene id: 523841:E6P09_RS18040
uniprot id: I3RA05
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

523841:E6P09 RS06410
gene id: 523841:E6P09_RS06410
uniprot id: I3R2D6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03840
gene id: 523841:E6P09_RS03840
uniprot id: I3R0X9
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11460
gene id: 523841:E6P09_RS11460
uniprot id: I3R584
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Dodecamer.
messages: Expression is induced in complex medium (CM) in which putrescine is both nitrogen (N) and carbon (C) source, in defined media (DM) with putrescine as the N source and glucose as the C source, DM with ammonium or nitrate as the N source and glucose as the C source, and in nitrogen starvation media (NS) without the N source and glucose as the C source (at protein level). Not expressed in CM in which yeast extract is both the N and the C source (at protein level). Constitutively expressed at different growth phases in CM in which yeast extract is both the N and the C source and in DM with ammonium or nitrate as the N source and glucose as the C source. Also constitutively expressed in NS regardless of the nitrogen deficiency time (48, 96 or 120 hours). Expression may be regulated at post-transcriptional level (PubMed:34439822). Expression is down-regulated in CM with 40 mM glutamine in the mid-exponential phase after nitrogen starvation for 72 hours (PubMed:32296946).
messages: Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. Not required for glutamine synthesis (PubMed:34439822). Is not able to compensate for the loss of glutamine synthetase (PubMed:32296946).
messages: No glutamate-putrescine ligase activity in complex medium (CM) in which putrescine is both nitrogen (N) and carbon (C) source, in defined media (DM) with putrescine as the N source and glucose as the C source nor in DM with nitrate as the N source and glucose as the C source.

523841:E6P09 RS06970
gene id: 523841:E6P09_RS06970
uniprot id: I3R2Q1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS10360
gene id: 523841:E6P09_RS10360
uniprot id: I3R4L5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

523841:E6P09 RS10460
gene id: 523841:E6P09_RS10460
uniprot id: I3R4N5
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS01290
gene id: 523841:E6P09_RS01290
uniprot id: I3R6B3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08615
gene id: 523841:E6P09_RS08615
uniprot id: I3R3M4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS09945
gene id: 523841:E6P09_RS09945
uniprot id: I3R4D4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

523841:E6P09 RS12700
gene id: 523841:E6P09_RS12700
uniprot id: I3R8C7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11495
gene id: 523841:E6P09_RS11495
uniprot id: Q02228
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial gas vesicle GvpC family.
messages: Confers stability, involved in shaping gas vesicles (GV), hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat.
messages: Detected as 2 slightly different sizes in vivo; the proteins appears larger in SDS-PAGE probably due to the acidic tail.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle

523841:E6P09 RS10630
gene id: 523841:E6P09_RS10630
uniprot id: I3R4R6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

523841:E6P09 RS13255
gene id: 523841:E6P09_RS13255
uniprot id: I3R823
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11235
gene id: 523841:E6P09_RS11235
uniprot id: I3R535
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

523841:E6P09 RS10285
gene id: 523841:E6P09_RS10285
uniprot id: I3R4K1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

523841:E6P09 RS08890
gene id: 523841:E6P09_RS08890
uniprot id: I3R3S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

523841:E6P09 RS02030
gene id: 523841:E6P09_RS02030
uniprot id: I3R5W9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS16275
gene id: 523841:E6P09_RS16275
uniprot id: I3RB42
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08775
gene id: 523841:E6P09_RS08775
uniprot id: I3R3Q8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS18835
gene id: 523841:E6P09_RS18835
uniprot id: I3R9C3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS00105
gene id: 523841:E6P09_RS00105
uniprot id: I3R6Z0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS17590
gene id: 523841:E6P09_RS17590
uniprot id: I3R9R2
names: Similarity
messages: Belongs to the peptidase S8 family.

523841:E6P09 RS01440
gene id: 523841:E6P09_RS01440
uniprot id: I3R684
names: Similarity
messages: Belongs to the PdaD family.

523841:E6P09 RS13280
gene id: 523841:E6P09_RS13280
uniprot id: I3R818
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

523841:E6P09 RS18430
gene id: 523841:E6P09_RS18430
uniprot id: I3R9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS14610
gene id: 523841:E6P09_RS14610
uniprot id: I3R7B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

523841:E6P09 RS18290
gene id: 523841:E6P09_RS18290
uniprot id: A0A059TYL5
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS09865
gene id: 523841:E6P09_RS09865
uniprot id: I3R4B8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

523841:E6P09 RS16585
gene id: 523841:E6P09_RS16585
uniprot id: M0IML6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00300
gene id: 523841:E6P09_RS00300
uniprot id: M0IVM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523841:E6P09 RS10475
gene id: 523841:E6P09_RS10475
uniprot id: I3R4N8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS13195
gene id: 523841:E6P09_RS13195
uniprot id: I3R836
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

523841:E6P09 RS13220
gene id: 523841:E6P09_RS13220
uniprot id: I3R831
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523841:E6P09 RS13475
gene id: 523841:E6P09_RS13475
uniprot id: I3R7X6
names: Similarity
messages: Belongs to the PspA/IM30 family.

523841:E6P09 RS06755
gene id: 523841:E6P09_RS06755
uniprot id: I3R2K8
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

523841:E6P09 RS04220
gene id: 523841:E6P09_RS04220
uniprot id: I3R153
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

523841:E6P09 RS12255
gene id: 523841:E6P09_RS12255
uniprot id: I3R8L5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

523841:E6P09 RS05515
gene id: 523841:E6P09_RS05515
uniprot id: I3R1W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

523841:E6P09 RS04365
gene id: 523841:E6P09_RS04365
uniprot id: I3R185
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

523841:E6P09 RS03900
gene id: 523841:E6P09_RS03900
uniprot id: I3R0Z1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS01465
gene id: 523841:E6P09_RS01465
uniprot id: I3R679
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS02700
gene id: 523841:E6P09_RS02700
uniprot id: I3R8Q8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

523841:E6P09 RS00190
gene id: 523841:E6P09_RS00190
uniprot id: I3R6X4
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

523841:E6P09 RS12400
gene id: 523841:E6P09_RS12400
uniprot id: I3R8I7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

523841:E6P09 RS16080
gene id: 523841:E6P09_RS16080
uniprot id: I3RB84
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

523841:E6P09 RS12765
gene id: 523841:E6P09_RS12765
uniprot id: I3R8B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

523841:E6P09 RS02715
gene id: 523841:E6P09_RS02715
uniprot id: I3R8R1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

523841:E6P09 RS04370
gene id: 523841:E6P09_RS04370
uniprot id: I3R186
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS05310
gene id: 523841:E6P09_RS05310
uniprot id: I3R1S3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS14675
gene id: 523841:E6P09_RS14675
uniprot id: I3R799
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

523841:E6P09 RS00575
gene id: 523841:E6P09_RS00575
uniprot id: I3R6Q2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14385
gene id: 523841:E6P09_RS14385
uniprot id: I3R7F2
names: Disruption Phenotype
names: Function
names: Subunit
messages: Cells lacking pccB and pccX genes accumulate a high level of propionyl-CoA, which would then inhibit CoA-dependent enzymes such as succinyl-CoA synthetase and could partially inhibit the TCA cycle. Also affected in growth and glucose utilization. Cells are unable to produce PHBV and show morphological abnormalitiess such as a decrease of PHBV granules.
messages: Part of the propionyl coenzyme A carboxylase (PCC) complex involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. The complex catalyzes the carboxylation of propionyl-CoA to methylmalonyl-CoA. PCC is also able to catalyze the carboxylation of acetyl-CoA. PccX could be responsible for the interaction of the biotin carboxylase and carboxyltransferase subunits.
messages: The propionyl coenzyme A carboxylase (PCC) complex is composed of three subunits: PccA (biotin carboxylase and biotin-carboxyl carrier), PccB (carboxyltransferase) and PccX.

523841:E6P09 RS06740
gene id: 523841:E6P09_RS06740
uniprot id: I3R2K5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523841:E6P09 RS05090
gene id: 523841:E6P09_RS05090
uniprot id: I3R1N0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

523841:E6P09 RS05455
gene id: 523841:E6P09_RS05455
uniprot id: I3R1V2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS12465
gene id: 523841:E6P09_RS12465
uniprot id: M0INC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523841:E6P09 RS13735
gene id: 523841:E6P09_RS13735
uniprot id: I3R7S7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

523841:E6P09 RS05165
gene id: 523841:E6P09_RS05165
uniprot id: I3R1P5
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS12855
gene id: 523841:E6P09_RS12855
uniprot id: I3R8A0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

523841:E6P09 RS10635
gene id: 523841:E6P09_RS10635
uniprot id: I3R4R7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

523841:E6P09 RS06895
gene id: 523841:E6P09_RS06895
uniprot id: I3R2N6
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

523841:E6P09 RS12285
gene id: 523841:E6P09_RS12285
uniprot id: M0IQN4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

523841:E6P09 RS05070
gene id: 523841:E6P09_RS05070
uniprot id: I3R1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

523841:E6P09 RS13710
gene id: 523841:E6P09_RS13710
uniprot id: I3R7T1
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

523841:E6P09 RS07445
gene id: 523841:E6P09_RS07445
uniprot id: I3R2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS06170
gene id: 523841:E6P09_RS06170
uniprot id: I3R290
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS06255
gene id: 523841:E6P09_RS06255
uniprot id: I3R2A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523841:E6P09 RS14845
gene id: 523841:E6P09_RS14845
uniprot id: I3R765
names: Similarity
messages: Belongs to the LarC family.

523841:E6P09 RS06735
gene id: 523841:E6P09_RS06735
uniprot id: I3R2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

523841:E6P09 RS05525
gene id: 523841:E6P09_RS05525
uniprot id: I3R1W6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

523841:E6P09 RS06775
gene id: 523841:E6P09_RS06775
uniprot id: I3R2L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

523841:E6P09 RS03060
gene id: 523841:E6P09_RS03060
uniprot id: I3R8X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

523841:E6P09 RS02770
gene id: 523841:E6P09_RS02770
uniprot id: I3R8S1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS19095
gene id: 523841:E6P09_RS19095
uniprot id: I3R933
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18425
gene id: 523841:E6P09_RS18425
uniprot id: M0J8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS01635
gene id: 523841:E6P09_RS01635
uniprot id: I3R644
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS15145
gene id: 523841:E6P09_RS15145
uniprot id: I3RAE8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12215
gene id: 523841:E6P09_RS12215
uniprot id: I3R8M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00400
gene id: 523841:E6P09_RS00400
uniprot id: I3R6T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

523841:E6P09 RS06235
gene id: 523841:E6P09_RS06235
uniprot id: I3R2A2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

523841:E6P09 RS16130
gene id: 523841:E6P09_RS16130
uniprot id: I3RB71
names: Similarity
messages: Belongs to the thioesterase PaaI family.

523841:E6P09 RS10595
gene id: 523841:E6P09_RS10595
uniprot id: I3R4Q9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS07920
gene id: 523841:E6P09_RS07920
uniprot id: I3R383
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

523841:E6P09 RS17695
gene id: 523841:E6P09_RS17695
uniprot id: I3R9T6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06835
gene id: 523841:E6P09_RS06835
uniprot id: I3R2M4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS02455
gene id: 523841:E6P09_RS02455
uniprot id: I3R5N5
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS17190
gene id: 523841:E6P09_RS17190
uniprot id: I3RAJ5
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS17985
gene id: 523841:E6P09_RS17985
uniprot id: I3R9Z2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: Deletion mutant is defective in both PHA biosynthesis and cell growth. The number of PHA granules is significantly lower.
messages: Polyhydroxyalkanoate (PHA) granule structural protein. Important for PHA granule formation and separation, and for cell growth.

523841:E6P09 RS10280
gene id: 523841:E6P09_RS10280
uniprot id: M0J6F6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
messages: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).

523841:E6P09 RS16425
gene id: 523841:E6P09_RS16425
uniprot id: I3RB10
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523841:E6P09 RS10565
gene id: 523841:E6P09_RS10565
uniprot id: I3R4Q3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10150
gene id: 523841:E6P09_RS10150
uniprot id: I3R4H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

523841:E6P09 RS01530
gene id: 523841:E6P09_RS01530
uniprot id: I3R665
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

523841:E6P09 RS14205
gene id: 523841:E6P09_RS14205
uniprot id: I3R7I1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08020
gene id: 523841:E6P09_RS08020
uniprot id: I3R3A4
names: Similarity
messages: Belongs to the peptidase M24B family.

523841:E6P09 RS11075
gene id: 523841:E6P09_RS11075
uniprot id: I3R504
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

523841:E6P09 RS19400
gene id: 523841:E6P09_RS19400
uniprot id: I3R990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

523841:E6P09 RS08535
gene id: 523841:E6P09_RS08535
uniprot id: I3R3K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523841:E6P09 RS15835
gene id: 523841:E6P09_RS15835
uniprot id: I3RBD6
names: Similarity
messages: Belongs to the UPF0045 family.

523841:E6P09 RS09150
gene id: 523841:E6P09_RS09150
uniprot id: I3R3Y1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14945
gene id: 523841:E6P09_RS14945
uniprot id: I3R744
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00055
gene id: 523841:E6P09_RS00055
uniprot id: I3R700
names: Similarity
messages: Belongs to the Ahb/Nir family.

523841:E6P09 RS00040
gene id: 523841:E6P09_RS00040
uniprot id: I3R703
names: Similarity
messages: Belongs to the serpin family.

523841:E6P09 RS02855
gene id: 523841:E6P09_RS02855
uniprot id: I3R8T7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523841:E6P09 RS08375
gene id: 523841:E6P09_RS08375
uniprot id: I3R3H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11685
gene id: 523841:E6P09_RS11685
uniprot id: I3R5C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

523841:E6P09 RS14210
gene id: 523841:E6P09_RS14210
uniprot id: I3R7I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

523841:E6P09 RS04615
gene id: 523841:E6P09_RS04615
uniprot id: I3R1D4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523841:E6P09 RS00850
gene id: 523841:E6P09_RS00850
uniprot id: I3R6J6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13685
gene id: 523841:E6P09_RS13685
uniprot id: I3R7T6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

523841:E6P09 RS02415
gene id: 523841:E6P09_RS02415
uniprot id: I3R5P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS13245
gene id: 523841:E6P09_RS13245
uniprot id: A0A059TPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS07790
gene id: 523841:E6P09_RS07790
uniprot id: I3R357
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

523841:E6P09 RS15940
gene id: 523841:E6P09_RS15940
uniprot id: I3RBB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS13570
gene id: 523841:E6P09_RS13570
uniprot id: I3R7V9
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS02055
gene id: 523841:E6P09_RS02055
uniprot id: I3R5W3
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

523841:E6P09 RS13940
gene id: 523841:E6P09_RS13940
uniprot id: I3R7N9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

523841:E6P09 RS13355
gene id: 523841:E6P09_RS13355
uniprot id: I3R802
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

523841:E6P09 RS08870
gene id: 523841:E6P09_RS08870
uniprot id: I3R3S4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00270
gene id: 523841:E6P09_RS00270
uniprot id: I3R6W0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS17005
gene id: 523841:E6P09_RS17005
uniprot id: I3RAN1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04150
gene id: 523841:E6P09_RS04150
uniprot id: I3R139
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

523841:E6P09 RS09740
gene id: 523841:E6P09_RS09740
uniprot id: I3R495
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

523841:E6P09 RS17090
gene id: 523841:E6P09_RS17090
uniprot id: I3RAL4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523841:E6P09 RS02610
gene id: 523841:E6P09_RS02610
uniprot id: M0J1V2
names: Similarity
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

523841:E6P09 RS10750
gene id: 523841:E6P09_RS10750
uniprot id: I3R4U0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS13950
gene id: 523841:E6P09_RS13950
uniprot id: I3R7N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS00900
gene id: 523841:E6P09_RS00900
uniprot id: I3R6I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS07880
gene id: 523841:E6P09_RS07880
uniprot id: I3R375
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

523841:E6P09 RS08370
gene id: 523841:E6P09_RS08370
uniprot id: I3R3H4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS02410
gene id: 523841:E6P09_RS02410
uniprot id: I3R5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS10855
gene id: 523841:E6P09_RS10855
uniprot id: I3R4W1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523841:E6P09 RS14195
gene id: 523841:E6P09_RS14195
uniprot id: I3R7I4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS13945
gene id: 523841:E6P09_RS13945
uniprot id: I3R7N8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS18920
gene id: 523841:E6P09_RS18920
uniprot id: I3R8Z8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS02285
gene id: 523841:E6P09_RS02285
uniprot id: I3R5R7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

523841:E6P09 RS10365
gene id: 523841:E6P09_RS10365
uniprot id: I3R4L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS04110
gene id: 523841:E6P09_RS04110
uniprot id: I3R131
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523841:E6P09 RS03935
gene id: 523841:E6P09_RS03935
uniprot id: I3R0Z8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS09925
gene id: 523841:E6P09_RS09925
uniprot id: I3R4D0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523841:E6P09 RS11645
gene id: 523841:E6P09_RS11645
uniprot id: I3R5C0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523841:E6P09 RS08045
gene id: 523841:E6P09_RS08045
uniprot id: I3R3A9
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12815
gene id: 523841:E6P09_RS12815
uniprot id: I3R8A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS10135
gene id: 523841:E6P09_RS10135
uniprot id: I3R4H2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

523841:E6P09 RS18720
gene id: 523841:E6P09_RS18720
uniprot id: I3R9K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523841:E6P09 RS12935
gene id: 523841:E6P09_RS12935
uniprot id: I3R885
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

523841:E6P09 RS18915
gene id: 523841:E6P09_RS18915
uniprot id: I3R8Z7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS12925
gene id: 523841:E6P09_RS12925
uniprot id: I3R887
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523841:E6P09 RS00005
gene id: 523841:E6P09_RS00005
uniprot id: I3R710
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

523841:E6P09 RS04590
gene id: 523841:E6P09_RS04590
uniprot id: I3R1C9
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523841:E6P09 RS18730
gene id: 523841:E6P09_RS18730
uniprot id: I3R9K7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03395
gene id: 523841:E6P09_RS03395
uniprot id: I3R0P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05600
gene id: 523841:E6P09_RS05600
uniprot id: I3R1X8
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

523841:E6P09 RS14400
gene id: 523841:E6P09_RS14400
uniprot id: I3R7E9
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10575
gene id: 523841:E6P09_RS10575
uniprot id: I3R4Q5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS12070
gene id: 523841:E6P09_RS12070
uniprot id: I3R5K3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

523841:E6P09 RS03560
gene id: 523841:E6P09_RS03560
uniprot id: B8ZYW3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Expressed during ammonium starvation under nitrate-rich conditions.
messages: Homotrimer (By similarity). Interacts with both GlnK1 and GlnK2 after ammonium shock (By similarity).
messages: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (By similarity). Transport is electrogenic (By similarity).

523841:E6P09 RS00310
gene id: 523841:E6P09_RS00310
uniprot id: I3R6V2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15015
gene id: 523841:E6P09_RS15015
uniprot id: I3R731
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS00065
gene id: 523841:E6P09_RS00065
uniprot id: I3R6Z8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

523841:E6P09 RS18680
gene id: 523841:E6P09_RS18680
uniprot id: I3R9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523841:E6P09 RS10035
gene id: 523841:E6P09_RS10035
uniprot id: I3R4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

523841:E6P09 RS12570
gene id: 523841:E6P09_RS12570
uniprot id: I3R8F2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS14135
gene id: 523841:E6P09_RS14135
uniprot id: I3R7J6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

523841:E6P09 RS04675
gene id: 523841:E6P09_RS04675
uniprot id: I3R1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

523841:E6P09 RS12500
gene id: 523841:E6P09_RS12500
uniprot id: I3R8G6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12660
gene id: 523841:E6P09_RS12660
uniprot id: I3R8D5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

523841:E6P09 RS11825
gene id: 523841:E6P09_RS11825
uniprot id: I3R5F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

523841:E6P09 RS17035
gene id: 523841:E6P09_RS17035
uniprot id: I3RAM5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

523841:E6P09 RS08625
gene id: 523841:E6P09_RS08625
uniprot id: I3R3M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS10165
gene id: 523841:E6P09_RS10165
uniprot id: M0J4T2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS12020
gene id: 523841:E6P09_RS12020
uniprot id: I3R5J2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11445
gene id: 523841:E6P09_RS11445
uniprot id: I3R581
names: Similarity
messages: Belongs to the Dps family.

523841:E6P09 RS11150
gene id: 523841:E6P09_RS11150
uniprot id: I3R519
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523841:E6P09 RS01065
gene id: 523841:E6P09_RS01065
uniprot id: M0IVE2
names: Subcellular Location Annotation
messages: chloroplast

523841:E6P09 RS18705
gene id: 523841:E6P09_RS18705
uniprot id: I3R9K2
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS13530
gene id: 523841:E6P09_RS13530
uniprot id: I3R7W7
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

523841:E6P09 RS08310
gene id: 523841:E6P09_RS08310
uniprot id: I3R3G1
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS03250
gene id: 523841:E6P09_RS03250
uniprot id: I3R0L4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

523841:E6P09 RS05730
gene id: 523841:E6P09_RS05730
uniprot id: I3R202
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523841:E6P09 RS13925
gene id: 523841:E6P09_RS13925
uniprot id: I3R7P2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

523841:E6P09 RS06165
gene id: 523841:E6P09_RS06165
uniprot id: I3R289
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS05480
gene id: 523841:E6P09_RS05480
uniprot id: I3R1V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

523841:E6P09 RS11980
gene id: 523841:E6P09_RS11980
uniprot id: I3R5I4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS05650
gene id: 523841:E6P09_RS05650
uniprot id: I3R1Y8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06465
gene id: 523841:E6P09_RS06465
uniprot id: I3R2E7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523841:E6P09 RS13325
gene id: 523841:E6P09_RS13325
uniprot id: I3R809
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

523841:E6P09 RS10405
gene id: 523841:E6P09_RS10405
uniprot id: I3R4M4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS16735
gene id: 523841:E6P09_RS16735
uniprot id: I3RAU1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

523841:E6P09 RS13840
gene id: 523841:E6P09_RS13840
uniprot id: I3R7Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

523841:E6P09 RS13430
gene id: 523841:E6P09_RS13430
uniprot id: I3R7Y5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00910
gene id: 523841:E6P09_RS00910
uniprot id: I3R6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS01400
gene id: 523841:E6P09_RS01400
uniprot id: I3R692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

523841:E6P09 RS16625
gene id: 523841:E6P09_RS16625
uniprot id: I3RAW8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

523841:E6P09 RS17735
gene id: 523841:E6P09_RS17735
uniprot id: I3R9U4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

523841:E6P09 RS16990
gene id: 523841:E6P09_RS16990
uniprot id: I3RAN4
names: Similarity
messages: Belongs to the citrate synthase family.

523841:E6P09 RS00150
gene id: 523841:E6P09_RS00150
uniprot id: I3R6Y2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

523841:E6P09 RS01525
gene id: 523841:E6P09_RS01525
uniprot id: I3R666
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

523841:E6P09 RS08630
gene id: 523841:E6P09_RS08630
uniprot id: I3R3M7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS18370
gene id: 523841:E6P09_RS18370
uniprot id: I3R9D2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS02705
gene id: 523841:E6P09_RS02705
uniprot id: I3R8Q9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

523841:E6P09 RS00705
gene id: 523841:E6P09_RS00705
uniprot id: I3R6M6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03000
gene id: 523841:E6P09_RS03000
uniprot id: I3R8W6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

523841:E6P09 RS15855
gene id: 523841:E6P09_RS15855
uniprot id: I3RBD2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

523841:E6P09 RS16785
gene id: 523841:E6P09_RS16785
uniprot id: I3RAT1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14425
gene id: 523841:E6P09_RS14425
uniprot id: I3R7E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

523841:E6P09 RS13785
gene id: 523841:E6P09_RS13785
uniprot id: I3R7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

523841:E6P09 RS02310
gene id: 523841:E6P09_RS02310
uniprot id: I3R5R2
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.

523841:E6P09 RS08315
gene id: 523841:E6P09_RS08315
uniprot id: I3R3G2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12015
gene id: 523841:E6P09_RS12015
uniprot id: I3R5J1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS15455
gene id: 523841:E6P09_RS15455
uniprot id: A0A059TZ36
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

523841:E6P09 RS05300
gene id: 523841:E6P09_RS05300
uniprot id: I3R1S1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523841:E6P09 RS14750
gene id: 523841:E6P09_RS14750
uniprot id: I3R784
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

523841:E6P09 RS01345
gene id: 523841:E6P09_RS01345
uniprot id: I3R6A3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

523841:E6P09 RS11260
gene id: 523841:E6P09_RS11260
uniprot id: I3R540
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00485
gene id: 523841:E6P09_RS00485
uniprot id: I3R6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

523841:E6P09 RS03820
gene id: 523841:E6P09_RS03820
uniprot id: I3R0X6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

523841:E6P09 RS08605
gene id: 523841:E6P09_RS08605
uniprot id: I3R3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523841:E6P09 RS05295
gene id: 523841:E6P09_RS05295
uniprot id: I3R1S0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523841:E6P09 RS10400
gene id: 523841:E6P09_RS10400
uniprot id: I3R4M3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03440
gene id: 523841:E6P09_RS03440
uniprot id: I3R0Q2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04260
gene id: 523841:E6P09_RS04260
uniprot id: I3R162
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS11690
gene id: 523841:E6P09_RS11690
uniprot id: I3R5C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

523841:E6P09 RS12840
gene id: 523841:E6P09_RS12840
uniprot id: I3R8A3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

523841:E6P09 RS05020
gene id: 523841:E6P09_RS05020
uniprot id: I3R1L6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS00340
gene id: 523841:E6P09_RS00340
uniprot id: I3R6U9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS16480
gene id: 523841:E6P09_RS16480
uniprot id: I3RB01
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS00475
gene id: 523841:E6P09_RS00475
uniprot id: I3R6S0
names: Similarity
messages: Belongs to the AOR/FOR family.

523841:E6P09 RS01615
gene id: 523841:E6P09_RS01615
uniprot id: I3R648
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS09885
gene id: 523841:E6P09_RS09885
uniprot id: I3R4C2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

523841:E6P09 RS14420
gene id: 523841:E6P09_RS14420
uniprot id: I3R7E5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

523841:E6P09 RS08265
gene id: 523841:E6P09_RS08265
uniprot id: I3R3F2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

523841:E6P09 RS18965
gene id: 523841:E6P09_RS18965
uniprot id: I3R908
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

523841:E6P09 RS18475
gene id: 523841:E6P09_RS18475
uniprot id: I3R9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS04795
gene id: 523841:E6P09_RS04795
uniprot id: I3R1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

523841:E6P09 RS11195
gene id: 523841:E6P09_RS11195
uniprot id: I3R527
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

523841:E6P09 RS12995
gene id: 523841:E6P09_RS12995
uniprot id: I3R873
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523841:E6P09 RS18465
gene id: 523841:E6P09_RS18465
uniprot id: I3R9F5
names: Similarity
messages: Belongs to the RutC family.

523841:E6P09 RS13160
gene id: 523841:E6P09_RS13160
uniprot id: I3R841
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

523841:E6P09 RS01355
gene id: 523841:E6P09_RS01355
uniprot id: I3R6A1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

523841:E6P09 RS11185
gene id: 523841:E6P09_RS11185
uniprot id: I3R525
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523841:E6P09 RS03835
gene id: 523841:E6P09_RS03835
uniprot id: I3R0X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS08555
gene id: 523841:E6P09_RS08555
uniprot id: I3R3L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

523841:E6P09 RS08035
gene id: 523841:E6P09_RS08035
uniprot id: I3R3A7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12835
gene id: 523841:E6P09_RS12835
uniprot id: I3R8A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

523841:E6P09 RS12380
gene id: 523841:E6P09_RS12380
uniprot id: I3R8J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523841:E6P09 RS01785
gene id: 523841:E6P09_RS01785
uniprot id: I3R614
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS09380
gene id: 523841:E6P09_RS09380
uniprot id: I3R428
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS01740
gene id: 523841:E6P09_RS01740
uniprot id: I3R623
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

523841:E6P09 RS00020
gene id: 523841:E6P09_RS00020
uniprot id: I3R707
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

523841:E6P09 RS09900
gene id: 523841:E6P09_RS09900
uniprot id: I3R4C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523841:E6P09 RS13745
gene id: 523841:E6P09_RS13745
uniprot id: I3R7S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

523841:E6P09 RS14200
gene id: 523841:E6P09_RS14200
uniprot id: I3R7I2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523841:E6P09 RS05055
gene id: 523841:E6P09_RS05055
uniprot id: I3R1M3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS04990
gene id: 523841:E6P09_RS04990
uniprot id: I3R1L0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

523841:E6P09 RS06340
gene id: 523841:E6P09_RS06340
uniprot id: I3R2C3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

523841:E6P09 RS11180
gene id: 523841:E6P09_RS11180
uniprot id: I3R524
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

523841:E6P09 RS10480
gene id: 523841:E6P09_RS10480
uniprot id: I3R4N9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS08300
gene id: 523841:E6P09_RS08300
uniprot id: I3R3F9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

523841:E6P09 RS18700
gene id: 523841:E6P09_RS18700
uniprot id: I3R9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity). This archaea does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction. Thus in this archaea BioD has a different substrate (By similarity).
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS03110
gene id: 523841:E6P09_RS03110
uniprot id: I3R0I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

523841:E6P09 RS08295
gene id: 523841:E6P09_RS08295
uniprot id: I3R3F8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

523841:E6P09 RS05475
gene id: 523841:E6P09_RS05475
uniprot id: I3R1V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

523841:E6P09 RS12100
gene id: 523841:E6P09_RS12100
uniprot id: I3R5K8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

523841:E6P09 RS18060
gene id: 523841:E6P09_RS18060
uniprot id: I3RA10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS13000
gene id: 523841:E6P09_RS13000
uniprot id: I3R872
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

523841:E6P09 RS14465
gene id: 523841:E6P09_RS14465
uniprot id: I3R7D9
names: Similarity
messages: Belongs to the TrpF family.

523841:E6P09 RS02000
gene id: 523841:E6P09_RS02000
uniprot id: I3R5X6
names: Similarity
messages: Belongs to the PDCD5 family.

523841:E6P09 RS03345
gene id: 523841:E6P09_RS03345
uniprot id: I3R0N3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS11275
gene id: 523841:E6P09_RS11275
uniprot id: M0J662
uniprot id: Q9HHB8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

523841:E6P09 RS10820
gene id: 523841:E6P09_RS10820
uniprot id: I3R4V4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06335
gene id: 523841:E6P09_RS06335
uniprot id: I3R2C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523841:E6P09 RS16350
gene id: 523841:E6P09_RS16350
uniprot id: A0A4P8P6Z4
uniprot id: I3RB26
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein probably processes pre-crRNA into individual crRNA units, and also plays a role in generation or stability of the CRISPR leader-repeat transcript. Cleaves an endogenous (non-invading) RNA; cuts a specific site within a sequence nearly identical to the cognate CRISPR repeat sequence in the 5' UTR of the transcript of provirus gene phiH, found in provirus 1. This digestion might be responsible for inhibiting (defective) provirus 1 excision.
messages: Does not produce mature length crRNA; precursor is non-specifically degraded. No accumulation of the CRISPR leader-repeat transcript. Allows excision of defective provirus 1 from its chromosomal locus (detected as restoration of the attachment site attA).
messages: There are 6 CRISPR RNA loci in this organism and a single cas gene locus. A CRISPR-Cas type I-B system.

523841:E6P09 RS03945
gene id: 523841:E6P09_RS03945
uniprot id: I3R100
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

523841:E6P09 RS04145
gene id: 523841:E6P09_RS04145
uniprot id: I3R138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

523841:E6P09 RS09185
gene id: 523841:E6P09_RS09185
uniprot id: I3R3Y8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03155
gene id: 523841:E6P09_RS03155
uniprot id: I3R0J6
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

523841:E6P09 RS17625
gene id: 523841:E6P09_RS17625
uniprot id: I3R9R9
names: Similarity
messages: Belongs to the NAPRTase family.

523841:E6P09 RS06405
gene id: 523841:E6P09_RS06405
uniprot id: I3R2D5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00905
gene id: 523841:E6P09_RS00905
uniprot id: I3R6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS14585
gene id: 523841:E6P09_RS14585
uniprot id: I3R7B7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS13110
gene id: 523841:E6P09_RS13110
uniprot id: I3R849
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

523841:E6P09 RS15160
gene id: 523841:E6P09_RS15160
uniprot id: I3RAE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS04075
gene id: 523841:E6P09_RS04075
uniprot id: I3R124
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS08790
gene id: 523841:E6P09_RS08790
uniprot id: I3R3R1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

523841:E6P09 RS11875
gene id: 523841:E6P09_RS11875
uniprot id: I3R5G3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS04230
gene id: 523841:E6P09_RS04230
uniprot id: I3R155
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

523841:E6P09 RS03545
gene id: 523841:E6P09_RS03545
uniprot id: I3R0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

523841:E6P09 RS07100
gene id: 523841:E6P09_RS07100
uniprot id: I3R2S6
names: Cofactor
messages: The crystal structure with reduced Cu(1+) has also been determined.

523841:E6P09 RS04690
gene id: 523841:E6P09_RS04690
uniprot id: I3R1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05225
gene id: 523841:E6P09_RS05225
uniprot id: I3R1Q7
names: Similarity
messages: Belongs to the citrate synthase family.

523841:E6P09 RS10690
gene id: 523841:E6P09_RS10690
uniprot id: M0J670
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00875
gene id: 523841:E6P09_RS00875
uniprot id: I3R6J1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS07900
gene id: 523841:E6P09_RS07900
uniprot id: I3R379
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS15930
gene id: 523841:E6P09_RS15930
uniprot id: I3RBB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

523841:E6P09 RS01550
gene id: 523841:E6P09_RS01550
uniprot id: I3R661
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

523841:E6P09 RS00200
gene id: 523841:E6P09_RS00200
uniprot id: I3R6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

523841:E6P09 RS01745
gene id: 523841:E6P09_RS01745
uniprot id: I3R622
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

523841:E6P09 RS04785
gene id: 523841:E6P09_RS04785
uniprot id: I3R1G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS16690
gene id: 523841:E6P09_RS16690
uniprot id: I3RAV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

523841:E6P09 RS12320
gene id: 523841:E6P09_RS12320
uniprot id: I3R8K3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS15935
gene id: 523841:E6P09_RS15935
uniprot id: I3RBB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS12360
gene id: 523841:E6P09_RS12360
uniprot id: I3R8J5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

523841:E6P09 RS14130
gene id: 523841:E6P09_RS14130
uniprot id: I3R7J7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04575
gene id: 523841:E6P09_RS04575
uniprot id: I3R1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

523841:E6P09 RS17730
gene id: 523841:E6P09_RS17730
uniprot id: M0J8A7
names: Similarity
messages: Belongs to the UPF0045 family.

523841:E6P09 RS18940
gene id: 523841:E6P09_RS18940
uniprot id: I3R903
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS03405
gene id: 523841:E6P09_RS03405
uniprot id: I3R0P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS14330
gene id: 523841:E6P09_RS14330
uniprot id: I3R7G3
names: Cofactor
names: Domain
names: Function
names: Subunit
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain.
messages: The propionyl coenzyme A carboxylase (PCC) complex is composed of three subunits: PccA (biotin carboxylase and biotin-carboxyl carrier), PccB (carboxyltransferase) and PccX.
messages: This is one of the subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase is involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation (PubMed:25398867). Propionyl-CoA carboxylase is also able to catalyze the carboxylation of acetyl-CoA (PubMed:25398867).

523841:E6P09 RS15475
gene id: 523841:E6P09_RS15475
uniprot id: I3RA81
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

523841:E6P09 RS18525
gene id: 523841:E6P09_RS18525
uniprot id: M0JBD1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

523841:E6P09 RS02795
gene id: 523841:E6P09_RS02795
uniprot id: I3R8S6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

523841:E6P09 RS13800
gene id: 523841:E6P09_RS13800
uniprot id: I3R7R4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03305
gene id: 523841:E6P09_RS03305
uniprot id: I3R0M6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

523841:E6P09 RS11740
gene id: 523841:E6P09_RS11740
uniprot id: I3R5D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS07940
gene id: 523841:E6P09_RS07940
uniprot id: I3R387
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10485
gene id: 523841:E6P09_RS10485
uniprot id: I3R4P0
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

523841:E6P09 RS07960
gene id: 523841:E6P09_RS07960
uniprot id: I3R391
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03990
gene id: 523841:E6P09_RS03990
uniprot id: I3R109
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

523841:E6P09 RS08675
gene id: 523841:E6P09_RS08675
uniprot id: I3R3N7
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS07905
gene id: 523841:E6P09_RS07905
uniprot id: I3R380
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS07890
gene id: 523841:E6P09_RS07890
uniprot id: I3R377
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

523841:E6P09 RS01545
gene id: 523841:E6P09_RS01545
uniprot id: I3R662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

523841:E6P09 RS13870
gene id: 523841:E6P09_RS13870
uniprot id: I3R7Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS08320
gene id: 523841:E6P09_RS08320
uniprot id: I3R3G3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS01730
gene id: 523841:E6P09_RS01730
uniprot id: I3R625
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

523841:E6P09 RS12960
gene id: 523841:E6P09_RS12960
uniprot id: I3R880
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

523841:E6P09 RS00405
gene id: 523841:E6P09_RS00405
uniprot id: I3R6T6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

523841:E6P09 RS00120
gene id: 523841:E6P09_RS00120
uniprot id: I3R6Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

523841:E6P09 RS06190
gene id: 523841:E6P09_RS06190
uniprot id: I3R293
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

523841:E6P09 RS14570
gene id: 523841:E6P09_RS14570
uniprot id: A0A059TXL0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14785
gene id: 523841:E6P09_RS14785
uniprot id: I3R776
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS00030
gene id: 523841:E6P09_RS00030
uniprot id: I3R705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

523841:E6P09 RS05890
gene id: 523841:E6P09_RS05890
uniprot id: I3R233
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523841:E6P09 RS11030
gene id: 523841:E6P09_RS11030
uniprot id: I3R4Z5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

523841:E6P09 RS01060
gene id: 523841:E6P09_RS01060
uniprot id: I3R6F7
names: Similarity
messages: Belongs to the GbsR family.

523841:E6P09 RS05305
gene id: 523841:E6P09_RS05305
uniprot id: I3R1S2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

523841:E6P09 RS10885
gene id: 523841:E6P09_RS10885
uniprot id: M0J973
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08100
gene id: 523841:E6P09_RS08100
uniprot id: I3R3C1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06475
gene id: 523841:E6P09_RS06475
uniprot id: I3R2E9
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10340
gene id: 523841:E6P09_RS10340
uniprot id: I3R4L1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

523841:E6P09 RS03350
gene id: 523841:E6P09_RS03350
uniprot id: I3R0N4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS01790
gene id: 523841:E6P09_RS01790
uniprot id: I3R613
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS12910
gene id: 523841:E6P09_RS12910
uniprot id: I3R890
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

523841:E6P09 RS08250
gene id: 523841:E6P09_RS08250
uniprot id: I3R3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

523841:E6P09 RS01565
gene id: 523841:E6P09_RS01565
uniprot id: I3R658
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

523841:E6P09 RS13655
gene id: 523841:E6P09_RS13655
uniprot id: I3R7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

523841:E6P09 RS16280
gene id: 523841:E6P09_RS16280
uniprot id: I3RB41
names: Similarity
messages: Belongs to the arginase family.

523841:E6P09 RS13075
gene id: 523841:E6P09_RS13075
uniprot id: I3R856
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523841:E6P09 RS13035
gene id: 523841:E6P09_RS13035
uniprot id: I3R865
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

523841:E6P09 RS07140
gene id: 523841:E6P09_RS07140
uniprot id: I3R2T4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

523841:E6P09 RS08525
gene id: 523841:E6P09_RS08525
uniprot id: I3R3K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523841:E6P09 RS11505
gene id: 523841:E6P09_RS11505
uniprot id: Q02229
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpD family.
messages: Causes a decrease in the amount of GvpE protein; tested in transgenic H.volcanii (PubMed:12864859, PubMed:17379705, PubMed:23589224) (Probable). Plays a role in repression of excess gas vesicle formation (PubMed:1282192, PubMed:8757736, PubMed:11160801, PubMed:12864859). In transformed H.volcanii, an internal deletion in this protein leads to very high gas vesicle production and overproduction of gvpA mRNA; complementation with wild-type GvpD under its own promoter yields normal gas vesicle production and gvpA transcripts. Overexpression under a strong promoter prevents gas vesicle formation and causes large decreases in gvpA transcripts (PubMed:11160801, PubMed:8757736). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Cytoplasm
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Highly up-regulated gas vesicle formation in H.volcanii; cells are tightly filled with gas vesicles, are nearly round and lyse easily. In transformed H.volcanii, gvpA is translated at high levels in both log and stationary phase. This is not a true deletion mutant but rather an in-frame removal of residues 117-423, so a shorter protein is probably translated (PubMed:1282192). The same deletion constitutively transcribes from both promoters, leading to greatly increased transcripts of both loci in exponential and stationary phases (PubMed:8757736).
messages: In Schmidt et al., GvpD comes from H.mediterranei while GvpE is from the c-locus of H.salinarum.
messages: Interacts with GvpE, also with c-GvpE from H.salinarum.
messages: Transcribed from mid-log to stationary phase, probably as a gvpD-gvpE RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). Accumulates in stationary phase (at protein level) (PubMed:12864859).

523841:E6P09 RS18960
gene id: 523841:E6P09_RS18960
uniprot id: I3R907
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

523841:E6P09 RS14215
gene id: 523841:E6P09_RS14215
uniprot id: I3R7H9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

523841:E6P09 RS13845
gene id: 523841:E6P09_RS13845
uniprot id: I3R7Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS11550
gene id: 523841:E6P09_RS11550
uniprot id: M0J8R7
uniprot id: Q02238
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Might interact with GvpA.
messages: No longer makes gas vesicles in H.volcanii; cells translate GvpA but do not make gas vesicles.
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are small, hollow, gas filled protein structures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS18350
gene id: 523841:E6P09_RS18350
uniprot id: I3R9C8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS09835
gene id: 523841:E6P09_RS09835
uniprot id: I3R4B3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

523841:E6P09 RS14170
gene id: 523841:E6P09_RS14170
uniprot id: I3R7I9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523841:E6P09 RS01995
gene id: 523841:E6P09_RS01995
uniprot id: I3R5X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS05115
gene id: 523841:E6P09_RS05115
uniprot id: I3R1N5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

523841:E6P09 RS17870
gene id: 523841:E6P09_RS17870
uniprot id: I3R9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06780
gene id: 523841:E6P09_RS06780
uniprot id: I3R2L3
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

523841:E6P09 RS10675
gene id: 523841:E6P09_RS10675
uniprot id: I3R4S5
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS05290
gene id: 523841:E6P09_RS05290
uniprot id: I3R1R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

523841:E6P09 RS08905
gene id: 523841:E6P09_RS08905
uniprot id: I3R3T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523841:E6P09 RS11230
gene id: 523841:E6P09_RS11230
uniprot id: I3R534
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

523841:E6P09 RS06120
gene id: 523841:E6P09_RS06120
uniprot id: I3R281
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

523841:E6P09 RS18755
gene id: 523841:E6P09_RS18755
uniprot id: I3R9L2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15170
gene id: 523841:E6P09_RS15170
uniprot id: I3RAE3
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06730
gene id: 523841:E6P09_RS06730
uniprot id: I3R2K3
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

523841:E6P09 RS06265
gene id: 523841:E6P09_RS06265
uniprot id: I3R2A8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

523841:E6P09 RS10115
gene id: 523841:E6P09_RS10115
uniprot id: I3R4G8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

523841:E6P09 RS06505
gene id: 523841:E6P09_RS06505
uniprot id: I3R2F5
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00125
gene id: 523841:E6P09_RS00125
uniprot id: I3R6Y6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

523841:E6P09 RS18555
gene id: 523841:E6P09_RS18555
uniprot id: I3R9H2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS01875
gene id: 523841:E6P09_RS01875
uniprot id: I3R5Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

523841:E6P09 RS03320
gene id: 523841:E6P09_RS03320
uniprot id: I3R0M9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS14575
gene id: 523841:E6P09_RS14575
uniprot id: I3R7B9
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

523841:E6P09 RS17610
gene id: 523841:E6P09_RS17610
uniprot id: I3R9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

523841:E6P09 RS00800
gene id: 523841:E6P09_RS00800
uniprot id: I3R6K7
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523841:E6P09 RS12730
gene id: 523841:E6P09_RS12730
uniprot id: I3R8C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

523841:E6P09 RS08800
gene id: 523841:E6P09_RS08800
uniprot id: I3R3R3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

523841:E6P09 RS05200
gene id: 523841:E6P09_RS05200
uniprot id: I3R1Q1
names: Similarity
messages: Belongs to the RutC family.

523841:E6P09 RS13020
gene id: 523841:E6P09_RS13020
uniprot id: I3R868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

523841:E6P09 RS16925
gene id: 523841:E6P09_RS16925
uniprot id: I3RAP8
names: Similarity
messages: Belongs to the RutC family.

523841:E6P09 RS15815
gene id: 523841:E6P09_RS15815
uniprot id: I3RBE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

523841:E6P09 RS01870
gene id: 523841:E6P09_RS01870
uniprot id: I3R5Z9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

523841:E6P09 RS12710
gene id: 523841:E6P09_RS12710
uniprot id: I3R8C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11020
gene id: 523841:E6P09_RS11020
uniprot id: I3R4Z3
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

523841:E6P09 RS09045
gene id: 523841:E6P09_RS09045
uniprot id: I3R3V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04395
gene id: 523841:E6P09_RS04395
uniprot id: I3R191
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00570
gene id: 523841:E6P09_RS00570
uniprot id: I3R6Q3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10665
gene id: 523841:E6P09_RS10665
uniprot id: I3R4S3
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

523841:E6P09 RS03665
gene id: 523841:E6P09_RS03665
uniprot id: I3R0U8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

523841:E6P09 RS02660
gene id: 523841:E6P09_RS02660
uniprot id: I3R8Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

523841:E6P09 RS07455
gene id: 523841:E6P09_RS07455
uniprot id: I3R2Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

523841:E6P09 RS18330
gene id: 523841:E6P09_RS18330
uniprot id: I3RA65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

523841:E6P09 RS03230
gene id: 523841:E6P09_RS03230
uniprot id: I3R0L1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

523841:E6P09 RS14485
gene id: 523841:E6P09_RS14485
uniprot id: I3R7D5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

523841:E6P09 RS09060
gene id: 523841:E6P09_RS09060
uniprot id: I3R3W2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS11290
gene id: 523841:E6P09_RS11290
uniprot id: M0J5P1
uniprot id: Q9HHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

523841:E6P09 RS10420
gene id: 523841:E6P09_RS10420
uniprot id: I3R4M7
names: Similarity
messages: Belongs to the acylphosphatase family.

523841:E6P09 RS04535
gene id: 523841:E6P09_RS04535
uniprot id: I3R1B8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523841:E6P09 RS10160
gene id: 523841:E6P09_RS10160
uniprot id: I3R4H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

523841:E6P09 RS02305
gene id: 523841:E6P09_RS02305
uniprot id: I3R5R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

523841:E6P09 RS05135
gene id: 523841:E6P09_RS05135
uniprot id: I3R1N9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

523841:E6P09 RS06330
gene id: 523841:E6P09_RS06330
uniprot id: I3R2C1
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

523841:E6P09 RS11165
gene id: 523841:E6P09_RS11165
uniprot id: I3R521
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

523841:E6P09 RS09355
gene id: 523841:E6P09_RS09355
uniprot id: I3R423
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15610
gene id: 523841:E6P09_RS15610
uniprot id: I3RBI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS08415
gene id: 523841:E6P09_RS08415
uniprot id: I3R3I3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS08815
gene id: 523841:E6P09_RS08815
uniprot id: I3R3R6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS17995
gene id: 523841:E6P09_RS17995
uniprot id: I3R9Z4
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PHA/PHB synthase family.
messages: Depletion of both phaC and phaE genes leads to complete loss of PHA synthase activity and PHBV production.
messages: Heterodimer with PhaE.
messages: Involved in the production of polyhydroxyalkonic acids (PHAs), which are water-insoluble biopolymers used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. PHAs are composed primarily of 3-hydroxybutyric acid (3HB) and 3-hydroxyvaleric acid (3HV). Required for the production of poly-beta-hydroxybutyrate (PHB) and poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV).
messages: PHB and PHBV are desirable bioplastic due to their biodegradability, biocompatibility, and mechanical properties. However, PHBV has better mechanical properties than PHB.

523841:E6P09 RS01035
gene id: 523841:E6P09_RS01035
uniprot id: I3R6G2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS11300
gene id: 523841:E6P09_RS11300
uniprot id: I3R549
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

523841:E6P09 RS01750
gene id: 523841:E6P09_RS01750
uniprot id: I3R621
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

523841:E6P09 RS13575
gene id: 523841:E6P09_RS13575
uniprot id: I3R7V8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523841:E6P09 RS10835
gene id: 523841:E6P09_RS10835
uniprot id: I3R4V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

523841:E6P09 RS06470
gene id: 523841:E6P09_RS06470
uniprot id: I3R2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

523841:E6P09 RS16680
gene id: 523841:E6P09_RS16680
uniprot id: I3RAV4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

523841:E6P09 RS11525
gene id: 523841:E6P09_RS11525
uniprot id: Q02233
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpH family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC. Might interact with GvpA.
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS01215
gene id: 523841:E6P09_RS01215
uniprot id: I3R6C6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS01960
gene id: 523841:E6P09_RS01960
uniprot id: I3R5Y3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS01390
gene id: 523841:E6P09_RS01390
uniprot id: I3R694
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04710
gene id: 523841:E6P09_RS04710
uniprot id: I3R1F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

523841:E6P09 RS10540
gene id: 523841:E6P09_RS10540
uniprot id: I3R4P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523841:E6P09 RS17725
gene id: 523841:E6P09_RS17725
uniprot id: I3R9U2
names: Similarity
messages: Belongs to the PrpD family.

523841:E6P09 RS15165
gene id: 523841:E6P09_RS15165
uniprot id: I3RAE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS17170
gene id: 523841:E6P09_RS17170
uniprot id: I3RAJ9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523841:E6P09 RS05710
gene id: 523841:E6P09_RS05710
uniprot id: I3R1Z8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

523841:E6P09 RS12705
gene id: 523841:E6P09_RS12705
uniprot id: I3R8C6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18240
gene id: 523841:E6P09_RS18240
uniprot id: A0A059TWJ1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12195
gene id: 523841:E6P09_RS12195
uniprot id: I3R8M7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523841:E6P09 RS04290
gene id: 523841:E6P09_RS04290
uniprot id: I3R168
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06430
gene id: 523841:E6P09_RS06430
uniprot id: M0J3L0
uniprot id: Q9V2S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

523841:E6P09 RS01990
gene id: 523841:E6P09_RS01990
uniprot id: I3R5X8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS02040
gene id: 523841:E6P09_RS02040
uniprot id: M0IT87
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

523841:E6P09 RS08795
gene id: 523841:E6P09_RS08795
uniprot id: I3R3R2
names: Cofactor
messages: Binds 1 copper ion per subunit.

523841:E6P09 RS13765
gene id: 523841:E6P09_RS13765
uniprot id: I3R7S1
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

523841:E6P09 RS11135
gene id: 523841:E6P09_RS11135
uniprot id: M0J9V3
names: Caution
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

523841:E6P09 RS16390
gene id: 523841:E6P09_RS16390
uniprot id: I3RB17
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS15670
gene id: 523841:E6P09_RS15670
uniprot id: I3RBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

523841:E6P09 RS11800
gene id: 523841:E6P09_RS11800
uniprot id: I3R5F0
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

523841:E6P09 RS04780
gene id: 523841:E6P09_RS04780
uniprot id: I3R1G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

523841:E6P09 RS05920
gene id: 523841:E6P09_RS05920
uniprot id: I3R240
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

523841:E6P09 RS18710
gene id: 523841:E6P09_RS18710
uniprot id: I3R9K3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+ (By similarity). Complements a bioA deletion in E.coli (PubMed:32042199).
messages: Belongs to the BioU family.
messages: In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.
messages: Monomer.

523841:E6P09 RS12120
gene id: 523841:E6P09_RS12120
uniprot id: I3R5L2
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04660
gene id: 523841:E6P09_RS04660
uniprot id: I3R1E3
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS14950
gene id: 523841:E6P09_RS14950
uniprot id: I3R743
names: Similarity
messages: Belongs to the peptidase S66 family.

523841:E6P09 RS12845
gene id: 523841:E6P09_RS12845
uniprot id: I3R8A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS03160
gene id: 523841:E6P09_RS03160
uniprot id: I3R0J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

523841:E6P09 RS13140
gene id: 523841:E6P09_RS13140
uniprot id: I3R844
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS16270
gene id: 523841:E6P09_RS16270
uniprot id: I3RB43
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

523841:E6P09 RS05765
gene id: 523841:E6P09_RS05765
uniprot id: I3R209
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

523841:E6P09 RS01685
gene id: 523841:E6P09_RS01685
uniprot id: I3R634
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Cytoplasm
messages: Enzyme stability and activity depend upon the salt concentration.
messages: Inhibited by cyanide and azide.
messages: Is probably a monomer (PubMed:16182473). Initially characterized as a dimer of proteins with a MW of 105 and 50 kDa (PubMed:11731152).
messages: Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation. Catalyzes the reduction of nitrate to nitrite, using ferredoxin as the electron donor. Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.
messages: Repressed by the presence of ammonium as nitrogen source.

523841:E6P09 RS00355
gene id: 523841:E6P09_RS00355
uniprot id: I3R6U6
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS06160
gene id: 523841:E6P09_RS06160
uniprot id: I3R288
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

523841:E6P09 RS06645
gene id: 523841:E6P09_RS06645
uniprot id: I3R2I4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08765
gene id: 523841:E6P09_RS08765
uniprot id: I3R3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06085
gene id: 523841:E6P09_RS06085
uniprot id: I3R274
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS11540
gene id: 523841:E6P09_RS11540
uniprot id: M0J604
uniprot id: Q02236
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpK family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es).
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).
messages: Vesicle

523841:E6P09 RS07765
gene id: 523841:E6P09_RS07765
uniprot id: I3R353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

523841:E6P09 RS00580
gene id: 523841:E6P09_RS00580
uniprot id: I3R6Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS16330
gene id: 523841:E6P09_RS16330
uniprot id: I3RB30
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

523841:E6P09 RS07935
gene id: 523841:E6P09_RS07935
uniprot id: I3R386
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

523841:E6P09 RS10850
gene id: 523841:E6P09_RS10850
uniprot id: I3R4W0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

523841:E6P09 RS13205
gene id: 523841:E6P09_RS13205
uniprot id: I3R834
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

523841:E6P09 RS06990
gene id: 523841:E6P09_RS06990
uniprot id: I3R2Q5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

523841:E6P09 RS05750
gene id: 523841:E6P09_RS05750
uniprot id: I3R206
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05895
gene id: 523841:E6P09_RS05895
uniprot id: I3R234
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03370
gene id: 523841:E6P09_RS03370
uniprot id: I3R0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523841:E6P09 RS13465
gene id: 523841:E6P09_RS13465
uniprot id: I3R7X8
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

523841:E6P09 RS11775
gene id: 523841:E6P09_RS11775
uniprot id: I3R5E5
names: Similarity
messages: Belongs to the GARS family.

523841:E6P09 RS16485
gene id: 523841:E6P09_RS16485
uniprot id: I3RAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523841:E6P09 RS01560
gene id: 523841:E6P09_RS01560
uniprot id: I3R659
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523841:E6P09 RS08420
gene id: 523841:E6P09_RS08420
uniprot id: I3R3I4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS01445
gene id: 523841:E6P09_RS01445
uniprot id: I3R683
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

523841:E6P09 RS16490
gene id: 523841:E6P09_RS16490
uniprot id: I3RAZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS03190
gene id: 523841:E6P09_RS03190
uniprot id: I3R0K3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS15265
gene id: 523841:E6P09_RS15265
uniprot id: I3RAC3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04175
gene id: 523841:E6P09_RS04175
uniprot id: I3R144
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS04355
gene id: 523841:E6P09_RS04355
uniprot id: I3R182
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523841:E6P09 RS10895
gene id: 523841:E6P09_RS10895
uniprot id: I3R4W9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

523841:E6P09 RS14110
gene id: 523841:E6P09_RS14110
uniprot id: I3R7K1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523841:E6P09 RS07250
gene id: 523841:E6P09_RS07250
uniprot id: I3R2V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS15915
gene id: 523841:E6P09_RS15915
uniprot id: I3RBB8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

523841:E6P09 RS01665
gene id: 523841:E6P09_RS01665
uniprot id: I3R638
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

523841:E6P09 RS16900
gene id: 523841:E6P09_RS16900
uniprot id: I3RAQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS00195
gene id: 523841:E6P09_RS00195
uniprot id: I3R6X3
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

523841:E6P09 RS18200
gene id: 523841:E6P09_RS18200
uniprot id: M0JAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11045
gene id: 523841:E6P09_RS11045
uniprot id: I3R4Z8
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06660
gene id: 523841:E6P09_RS06660
uniprot id: I3R2I7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS13550
gene id: 523841:E6P09_RS13550
uniprot id: I3R7W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

523841:E6P09 RS12315
gene id: 523841:E6P09_RS12315
uniprot id: I3R8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS06345
gene id: 523841:E6P09_RS06345
uniprot id: I3R2C4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS05915
gene id: 523841:E6P09_RS05915
uniprot id: I3R238
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523841:E6P09 RS13025
gene id: 523841:E6P09_RS13025
uniprot id: I3R867
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

523841:E6P09 RS14865
gene id: 523841:E6P09_RS14865
uniprot id: I3R761
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523841:E6P09 RS01650
gene id: 523841:E6P09_RS01650
uniprot id: I3R641
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS05675
gene id: 523841:E6P09_RS05675
uniprot id: I3R1Z2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

523841:E6P09 RS12805
gene id: 523841:E6P09_RS12805
uniprot id: I3R8A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

523841:E6P09 RS03720
gene id: 523841:E6P09_RS03720
uniprot id: I3R0V9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

523841:E6P09 RS14355
gene id: 523841:E6P09_RS14355
uniprot id: I3R7F8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13630
gene id: 523841:E6P09_RS13630
uniprot id: I3R7U7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

523841:E6P09 RS16980
gene id: 523841:E6P09_RS16980
uniprot id: M0IMU7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11970
gene id: 523841:E6P09_RS11970
uniprot id: I3R5I2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12890
gene id: 523841:E6P09_RS12890
uniprot id: I3R894
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

523841:E6P09 RS19085
gene id: 523841:E6P09_RS19085
uniprot id: I3R931
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS14555
gene id: 523841:E6P09_RS14555
uniprot id: I3R7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04600
gene id: 523841:E6P09_RS04600
uniprot id: I3R1D1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

523841:E6P09 RS14540
gene id: 523841:E6P09_RS14540
uniprot id: I3R7C5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04870
gene id: 523841:E6P09_RS04870
uniprot id: I3R1I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS18650
gene id: 523841:E6P09_RS18650
uniprot id: I3R9J1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523841:E6P09 RS08550
gene id: 523841:E6P09_RS08550
uniprot id: I3R3L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08635
gene id: 523841:E6P09_RS08635
uniprot id: I3R3M8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

523841:E6P09 RS00890
gene id: 523841:E6P09_RS00890
uniprot id: I3R6I8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS05630
gene id: 523841:E6P09_RS05630
uniprot id: I3R1Y4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

523841:E6P09 RS01770
gene id: 523841:E6P09_RS01770
uniprot id: I3R617
names: Similarity
messages: Belongs to the HAM1 NTPase family.

523841:E6P09 RS11835
gene id: 523841:E6P09_RS11835
uniprot id: I3R5F6
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

523841:E6P09 RS11730
gene id: 523841:E6P09_RS11730
uniprot id: I3R5D5
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

523841:E6P09 RS01575
gene id: 523841:E6P09_RS01575
uniprot id: Q2VEQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.
messages: Homotetramer.

523841:E6P09 RS04340
gene id: 523841:E6P09_RS04340
uniprot id: I3R179
names: Similarity
messages: Belongs to the threonine aldolase family.

523841:E6P09 RS13250
gene id: 523841:E6P09_RS13250
uniprot id: I3R824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS11145
gene id: 523841:E6P09_RS11145
uniprot id: I3R518
names: Similarity
messages: Belongs to the UPF0212 family.

523841:E6P09 RS03430
gene id: 523841:E6P09_RS03430
uniprot id: I3R0Q0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS09405
gene id: 523841:E6P09_RS09405
uniprot id: I3R433
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

523841:E6P09 RS14005
gene id: 523841:E6P09_RS14005
uniprot id: I3R7M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS15180
gene id: 523841:E6P09_RS15180
uniprot id: I3RAE0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS03255
gene id: 523841:E6P09_RS03255
uniprot id: I3R0L5
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

523841:E6P09 RS03310
gene id: 523841:E6P09_RS03310
uniprot id: I3R0M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

523841:E6P09 RS01690
gene id: 523841:E6P09_RS01690
uniprot id: I3R633
names: Similarity
messages: Belongs to the AAA ATPase family.

523841:E6P09 RS10745
gene id: 523841:E6P09_RS10745
uniprot id: I3R4T9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS07865
gene id: 523841:E6P09_RS07865
uniprot id: I3R372
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

523841:E6P09 RS05935
gene id: 523841:E6P09_RS05935
uniprot id: I3R243
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

523841:E6P09 RS13890
gene id: 523841:E6P09_RS13890
uniprot id: I3R7P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

523841:E6P09 RS04645
gene id: 523841:E6P09_RS04645
uniprot id: I3R1E0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06075
gene id: 523841:E6P09_RS06075
uniprot id: I3R272
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS17455
gene id: 523841:E6P09_RS17455
uniprot id: A0A059TQY9
uniprot id: I3R9N1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups per subunit.
messages: Cell membrane
messages: Membrane
messages: Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.
messages: Proposed to confer antimycin sensitivity to the respiratory nitrate reductase.
messages: The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. Proposed membrane-embedded heme-iron subunit involved in a protonmotive Q-cycle mechanism-based electron transfer to the beta subunit.

523841:E6P09 RS02015
gene id: 523841:E6P09_RS02015
uniprot id: I3R5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

523841:E6P09 RS12575
gene id: 523841:E6P09_RS12575
uniprot id: I3R8F1
names: Similarity
messages: Belongs to the UPF0179 family.

523841:E6P09 RS14175
gene id: 523841:E6P09_RS14175
uniprot id: I3R7I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.

523841:E6P09 RS02370
gene id: 523841:E6P09_RS02370
uniprot id: I3R5Q4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS12780
gene id: 523841:E6P09_RS12780
uniprot id: I3R8B3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS17690
gene id: 523841:E6P09_RS17690
uniprot id: I3R9T5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS07405
gene id: 523841:E6P09_RS07405
uniprot id: A0A4P8P6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

523841:E6P09 RS05320
gene id: 523841:E6P09_RS05320
uniprot id: I3R1S5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

523841:E6P09 RS16150
gene id: 523841:E6P09_RS16150
uniprot id: I3RB67
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

523841:E6P09 RS17175
gene id: 523841:E6P09_RS17175
uniprot id: I3RAJ8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

523841:E6P09 RS12210
gene id: 523841:E6P09_RS12210
uniprot id: I3R8M4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

523841:E6P09 RS05855
gene id: 523841:E6P09_RS05855
uniprot id: I3R226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

523841:E6P09 RS05580
gene id: 523841:E6P09_RS05580
uniprot id: I3R1X4
names: Subunit
messages: Homotrimer.

523841:E6P09 RS05685
gene id: 523841:E6P09_RS05685
uniprot id: I3R1Z4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS10375
gene id: 523841:E6P09_RS10375
uniprot id: I3R4L8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS13040
gene id: 523841:E6P09_RS13040
uniprot id: I3R864
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

523841:E6P09 RS02870
gene id: 523841:E6P09_RS02870
uniprot id: I3R8U0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

523841:E6P09 RS13855
gene id: 523841:E6P09_RS13855
uniprot id: I3R7Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

523841:E6P09 RS03715
gene id: 523841:E6P09_RS03715
uniprot id: I3R0V8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

523841:E6P09 RS17580
gene id: 523841:E6P09_RS17580
uniprot id: I3R9R0
names: Similarity
messages: Belongs to the selenium-binding protein family.

523841:E6P09 RS04030
gene id: 523841:E6P09_RS04030
uniprot id: I3R116
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

523841:E6P09 RS06310
gene id: 523841:E6P09_RS06310
uniprot id: I3R2B6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03805
gene id: 523841:E6P09_RS03805
uniprot id: M0J3C0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

523841:E6P09 RS16960
gene id: 523841:E6P09_RS16960
uniprot id: I3RAP0
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

523841:E6P09 RS12060
gene id: 523841:E6P09_RS12060
uniprot id: I3R5K1
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS04760
gene id: 523841:E6P09_RS04760
uniprot id: I3R1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS03010
gene id: 523841:E6P09_RS03010
uniprot id: I3R8W9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

523841:E6P09 RS09195
gene id: 523841:E6P09_RS09195
uniprot id: I3R3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523841:E6P09 RS14490
gene id: 523841:E6P09_RS14490
uniprot id: I3R7D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS01040
gene id: 523841:E6P09_RS01040
uniprot id: A0A059TWA6
names: Similarity
messages: Belongs to the peptidase S8 family.

523841:E6P09 RS10705
gene id: 523841:E6P09_RS10705
uniprot id: I3R4T0
names: Similarity
messages: Belongs to the isochorismate synthase family.

523841:E6P09 RS08360
gene id: 523841:E6P09_RS08360
uniprot id: I3R3H2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06975
gene id: 523841:E6P09_RS06975
uniprot id: I3R2Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

523841:E6P09 RS17910
gene id: 523841:E6P09_RS17910
uniprot id: I3R9X6
names: Similarity
messages: Belongs to the AHA1 family.

523841:E6P09 RS17770
gene id: 523841:E6P09_RS17770
uniprot id: I3R9V1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

523841:E6P09 RS13115
gene id: 523841:E6P09_RS13115
uniprot id: I3R848
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

523841:E6P09 RS02530
gene id: 523841:E6P09_RS02530
uniprot id: I3R5M0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS07120
gene id: 523841:E6P09_RS07120
uniprot id: I3R2T0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

523841:E6P09 RS02730
gene id: 523841:E6P09_RS02730
uniprot id: I3R8R4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523841:E6P09 RS01420
gene id: 523841:E6P09_RS01420
uniprot id: I3R688
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

523841:E6P09 RS06480
gene id: 523841:E6P09_RS06480
uniprot id: I3R2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

523841:E6P09 RS11320
gene id: 523841:E6P09_RS11320
uniprot id: I3R553
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

523841:E6P09 RS15480
gene id: 523841:E6P09_RS15480
uniprot id: I3RA80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

523841:E6P09 RS00615
gene id: 523841:E6P09_RS00615
uniprot id: I3R6P4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523841:E6P09 RS10725
gene id: 523841:E6P09_RS10725
uniprot id: I3R4T5
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04940
gene id: 523841:E6P09_RS04940
uniprot id: M0J2R7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS12235
gene id: 523841:E6P09_RS12235
uniprot id: I3R8L9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

523841:E6P09 RS10270
gene id: 523841:E6P09_RS10270
uniprot id: I3R4J8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS15310
gene id: 523841:E6P09_RS15310
uniprot id: A0A059TZP7
names: Similarity
messages: Belongs to the SUI1 family.

523841:E6P09 RS00695
gene id: 523841:E6P09_RS00695
uniprot id: I3R6M8
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS18930
gene id: 523841:E6P09_RS18930
uniprot id: I3R901
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

523841:E6P09 RS03755
gene id: 523841:E6P09_RS03755
uniprot id: I3R0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

523841:E6P09 RS14700
gene id: 523841:E6P09_RS14700
uniprot id: A0A059TWU9
uniprot id: I3R794
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Probable secreted halophilic serine protease showing proteolytic activity toward the protease general substrate azocasein.
messages: Secreted

523841:E6P09 RS00435
gene id: 523841:E6P09_RS00435
uniprot id: I3R6S9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

523841:E6P09 RS01760
gene id: 523841:E6P09_RS01760
uniprot id: I3R619
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

523841:E6P09 RS03875
gene id: 523841:E6P09_RS03875
uniprot id: I3R0Y6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

523841:E6P09 RS13955
gene id: 523841:E6P09_RS13955
uniprot id: I3R7N6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

523841:E6P09 RS03400
gene id: 523841:E6P09_RS03400
uniprot id: I3R0P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS09785
gene id: 523841:E6P09_RS09785
uniprot id: I3R4A3
names: Similarity
messages: Belongs to the peptidase C56 family.

523841:E6P09 RS11870
gene id: 523841:E6P09_RS11870
uniprot id: I3R5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

523841:E6P09 RS06215
gene id: 523841:E6P09_RS06215
uniprot id: I3R298
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS04305
gene id: 523841:E6P09_RS04305
uniprot id: I3R171
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

523841:E6P09 RS06940
gene id: 523841:E6P09_RS06940
uniprot id: I3R2P5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

523841:E6P09 RS03760
gene id: 523841:E6P09_RS03760
uniprot id: I3R0W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

523841:E6P09 RS14460
gene id: 523841:E6P09_RS14460
uniprot id: I3R7E0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13790
gene id: 523841:E6P09_RS13790
uniprot id: I3R7R6
names: Similarity
messages: Belongs to the UPF0045 family.

523841:E6P09 RS18715
gene id: 523841:E6P09_RS18715
uniprot id: I3R9K4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13600
gene id: 523841:E6P09_RS13600
uniprot id: I3R7V3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

523841:E6P09 RS15565
gene id: 523841:E6P09_RS15565
uniprot id: I3RBJ1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11405
gene id: 523841:E6P09_RS11405
uniprot id: I3R572
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

523841:E6P09 RS01755
gene id: 523841:E6P09_RS01755
uniprot id: I3R620
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

523841:E6P09 RS04210
gene id: 523841:E6P09_RS04210
uniprot id: I3R151
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS00605
gene id: 523841:E6P09_RS00605
uniprot id: I3R6P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS13090
gene id: 523841:E6P09_RS13090
uniprot id: I3R853
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

523841:E6P09 RS12460
gene id: 523841:E6P09_RS12460
uniprot id: I3R8H5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS06920
gene id: 523841:E6P09_RS06920
uniprot id: I3R2P1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS13905
gene id: 523841:E6P09_RS13905
uniprot id: M0IQI7
uniprot id: P50557
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

523841:E6P09 RS05035
gene id: 523841:E6P09_RS05035
uniprot id: I3R1L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS07160
gene id: 523841:E6P09_RS07160
uniprot id: I3R2T8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

523841:E6P09 RS06900
gene id: 523841:E6P09_RS06900
uniprot id: I3R2N7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS13065
gene id: 523841:E6P09_RS13065
uniprot id: I3R858
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

523841:E6P09 RS16660
gene id: 523841:E6P09_RS16660
uniprot id: I3RAW2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS03500
gene id: 523841:E6P09_RS03500
uniprot id: I3R0R3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03810
gene id: 523841:E6P09_RS03810
uniprot id: I3R0X4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS03315
gene id: 523841:E6P09_RS03315
uniprot id: I3R0M8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06150
gene id: 523841:E6P09_RS06150
uniprot id: I3R286
names: Similarity
messages: Belongs to the UPF0440 family.

523841:E6P09 RS03035
gene id: 523841:E6P09_RS03035
uniprot id: I3R8X4
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03050
gene id: 523841:E6P09_RS03050
uniprot id: I3R8X7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06195
gene id: 523841:E6P09_RS06195
uniprot id: I3R294
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03725
gene id: 523841:E6P09_RS03725
uniprot id: I3R0W0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

523841:E6P09 RS07275
gene id: 523841:E6P09_RS07275
uniprot id: I3R2W1
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

523841:E6P09 RS06930
gene id: 523841:E6P09_RS06930
uniprot id: I3R2P3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

523841:E6P09 RS06765
gene id: 523841:E6P09_RS06765
uniprot id: I3R2L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

523841:E6P09 RS13095
gene id: 523841:E6P09_RS13095
uniprot id: I3R852
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523841:E6P09 RS04165
gene id: 523841:E6P09_RS04165
uniprot id: I3R142
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

523841:E6P09 RS12300
gene id: 523841:E6P09_RS12300
uniprot id: I3R8K7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

523841:E6P09 RS04970
gene id: 523841:E6P09_RS04970
uniprot id: I3R1K5
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06435
gene id: 523841:E6P09_RS06435
uniprot id: I3R2E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

523841:E6P09 RS09040
gene id: 523841:E6P09_RS09040
uniprot id: I3R3V8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS01795
gene id: 523841:E6P09_RS01795
uniprot id: I3R612
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS04810
gene id: 523841:E6P09_RS04810
uniprot id: I3R1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523841:E6P09 RS03705
gene id: 523841:E6P09_RS03705
uniprot id: I3R0V6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

523841:E6P09 RS04000
gene id: 523841:E6P09_RS04000
uniprot id: I3R111
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

523841:E6P09 RS06420
gene id: 523841:E6P09_RS06420
uniprot id: I3R2D8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

523841:E6P09 RS10870
gene id: 523841:E6P09_RS10870
uniprot id: I3R4W4
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

523841:E6P09 RS17045
gene id: 523841:E6P09_RS17045
uniprot id: M0IKV0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06245
gene id: 523841:E6P09_RS06245
uniprot id: I3R2A4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS01655
gene id: 523841:E6P09_RS01655
uniprot id: I3R640
names: Similarity
messages: Belongs to the AOR/FOR family.

523841:E6P09 RS02635
gene id: 523841:E6P09_RS02635
uniprot id: I3R8P5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523841:E6P09 RS16505
gene id: 523841:E6P09_RS16505
uniprot id: I3RAZ3
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS02820
gene id: 523841:E6P09_RS02820
uniprot id: I3R8T1
names: Similarity
messages: Belongs to the IMPACT family.

523841:E6P09 RS00075
gene id: 523841:E6P09_RS00075
uniprot id: I3R6Z6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

523841:E6P09 RS04585
gene id: 523841:E6P09_RS04585
uniprot id: I3R1C8
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523841:E6P09 RS11485
gene id: 523841:E6P09_RS11485
uniprot id: Q02240
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the gas vesicle (GV), may play a role in transcription and/or RNA stability and/or in GV assembly. Gas vesicles are small, hollow, gas filled protein structures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated shallow brine pools of their habitat.
messages: Belongs to the gas vesicle GvpO family.
messages: Cytoplasm
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Forms homodimers, forms a GvpN-GvpO heterodimer, interacts with GvpC, GvpF, GvpI and GvpL, might interact with GvpA.
messages: Gas vesicle
messages: No longer makes gas vesicles in H.volcanii; cells translate GvpA but do not make gas vesicles.

523841:E6P09 RS10395
gene id: 523841:E6P09_RS10395
uniprot id: I3R4M2
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14470
gene id: 523841:E6P09_RS14470
uniprot id: I3R7D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

523841:E6P09 RS17440
gene id: 523841:E6P09_RS17440
uniprot id: I3R9M8
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [3Fe-4S] cluster per subunit.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: By nitrate.
messages: Cell membrane
messages: Inhibited by cyanide, azide and antimycin A. Enzyme stability is not dependent on salt concentration.
messages: Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.
messages: The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers.

523841:E6P09 RS10890
gene id: 523841:E6P09_RS10890
uniprot id: I3R4W8
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

523841:E6P09 RS08745
gene id: 523841:E6P09_RS08745
uniprot id: I3R3Q1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

523841:E6P09 RS12610
gene id: 523841:E6P09_RS12610
uniprot id: I3R8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

523841:E6P09 RS14745
gene id: 523841:E6P09_RS14745
uniprot id: I3R785
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

523841:E6P09 RS05850
gene id: 523841:E6P09_RS05850
uniprot id: I3R225
names: Cofactor
messages: The crystal structure with reduced Cu(1+) has also been determined.

523841:E6P09 RS01675
gene id: 523841:E6P09_RS01675
uniprot id: A0A059TN56
uniprot id: I3R636
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

523841:E6P09 RS07085
gene id: 523841:E6P09_RS07085
uniprot id: I3R2S3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS19150
gene id: 523841:E6P09_RS19150
uniprot id: I3R944
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

523841:E6P09 RS12940
gene id: 523841:E6P09_RS12940
uniprot id: I3R884
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523841:E6P09 RS04435
gene id: 523841:E6P09_RS04435
uniprot id: I3R199
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11190
gene id: 523841:E6P09_RS11190
uniprot id: I3R526
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

523841:E6P09 RS00600
gene id: 523841:E6P09_RS00600
uniprot id: I3R6P7
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

523841:E6P09 RS00045
gene id: 523841:E6P09_RS00045
uniprot id: I3R702
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06070
gene id: 523841:E6P09_RS06070
uniprot id: I3R271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS03965
gene id: 523841:E6P09_RS03965
uniprot id: I3R104
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

523841:E6P09 RS12850
gene id: 523841:E6P09_RS12850
uniprot id: I3R8A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS15865
gene id: 523841:E6P09_RS15865
uniprot id: I3RBD0
names: Similarity
messages: Belongs to the FabD family.

523841:E6P09 RS01495
gene id: 523841:E6P09_RS01495
uniprot id: I3R673
names: Similarity
messages: Belongs to the SUI1 family.

523841:E6P09 RS09915
gene id: 523841:E6P09_RS09915
uniprot id: I3R4C8
names: Similarity
messages: Belongs to the peptidase M24B family.

523841:E6P09 RS13590
gene id: 523841:E6P09_RS13590
uniprot id: I3R7V5
names: Similarity
messages: Belongs to the PEPCase type 1 family.

523841:E6P09 RS09030
gene id: 523841:E6P09_RS09030
uniprot id: I3R3V6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08915
gene id: 523841:E6P09_RS08915
uniprot id: I3R3T2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

523841:E6P09 RS06425
gene id: 523841:E6P09_RS06425
uniprot id: M0J032
uniprot id: Q9V2S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

523841:E6P09 RS04540
gene id: 523841:E6P09_RS04540
uniprot id: I3R1B9
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

523841:E6P09 RS07010
gene id: 523841:E6P09_RS07010
uniprot id: I3R2Q9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

523841:E6P09 RS18410
gene id: 523841:E6P09_RS18410
uniprot id: I3R9E1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04725
gene id: 523841:E6P09_RS04725
uniprot id: I3R1F6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523841:E6P09 RS07040
gene id: 523841:E6P09_RS07040
uniprot id: M0IZA1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

523841:E6P09 RS17415
gene id: 523841:E6P09_RS17415
uniprot id: I3R9M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

523841:E6P09 RS00230
gene id: 523841:E6P09_RS00230
uniprot id: M0IUQ8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

523841:E6P09 RS12945
gene id: 523841:E6P09_RS12945
uniprot id: I3R883
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

523841:E6P09 RS17940
gene id: 523841:E6P09_RS17940
uniprot id: I3R9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS03980
gene id: 523841:E6P09_RS03980
uniprot id: I3R107
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

523841:E6P09 RS14545
gene id: 523841:E6P09_RS14545
uniprot id: I3R7C4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS15880
gene id: 523841:E6P09_RS15880
uniprot id: I3RBC7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS16320
gene id: 523841:E6P09_RS16320
uniprot id: I3RB32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

523841:E6P09 RS06385
gene id: 523841:E6P09_RS06385
uniprot id: I3R2D0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS13275
gene id: 523841:E6P09_RS13275
uniprot id: I3R819
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

523841:E6P09 RS10615
gene id: 523841:E6P09_RS10615
uniprot id: I3R4R3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523841:E6P09 RS14780
gene id: 523841:E6P09_RS14780
uniprot id: I3R777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

523841:E6P09 RS12375
gene id: 523841:E6P09_RS12375
uniprot id: M0IS78
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523841:E6P09 RS10775
gene id: 523841:E6P09_RS10775
uniprot id: I3R4U5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS13930
gene id: 523841:E6P09_RS13930
uniprot id: I3R7P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS03020
gene id: 523841:E6P09_RS03020
uniprot id: M0J4V4
names: Similarity
messages: Belongs to the cytochrome P450 family.

523841:E6P09 RS09035
gene id: 523841:E6P09_RS09035
uniprot id: I3R3V7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11515
gene id: 523841:E6P09_RS11515
uniprot id: M0J609
uniprot id: Q02231
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the gas vesicle, may be involved in preventing GvpA aggregation during gas vesicle nucleation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Binds GvpA.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). Accumulates in exponential but not stationary phase (at protein level) (PubMed:12864859).
messages: Vesicle

523841:E6P09 RS05075
gene id: 523841:E6P09_RS05075
uniprot id: I3R1M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

523841:E6P09 RS16950
gene id: 523841:E6P09_RS16950
uniprot id: I3RAP3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

523841:E6P09 RS11535
gene id: 523841:E6P09_RS11535
uniprot id: M0J5I9
uniprot id: Q02235
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the gas vesicle, proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Belongs to the gas vesicle GvpA family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpA.
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS02785
gene id: 523841:E6P09_RS02785
uniprot id: I3R8S4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

523841:E6P09 RS16285
gene id: 523841:E6P09_RS16285
uniprot id: I3RB40
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS06185
gene id: 523841:E6P09_RS06185
uniprot id: I3R292
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

523841:E6P09 RS16105
gene id: 523841:E6P09_RS16105
uniprot id: I3RB77
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS05910
gene id: 523841:E6P09_RS05910
uniprot id: I3R237
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS08570
gene id: 523841:E6P09_RS08570
uniprot id: I3R3L5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

523841:E6P09 RS09850
gene id: 523841:E6P09_RS09850
uniprot id: I3R4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

523841:E6P09 RS11585
gene id: 523841:E6P09_RS11585
uniprot id: I3R5A9
names: Subcellular Location Annotation
messages: Nucleus

523841:E6P09 RS00810
gene id: 523841:E6P09_RS00810
uniprot id: I3R6K5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS03645
gene id: 523841:E6P09_RS03645
uniprot id: I3R0U4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS17700
gene id: 523841:E6P09_RS17700
uniprot id: I3R9T7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS08485
gene id: 523841:E6P09_RS08485
uniprot id: I3R3J8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

523841:E6P09 RS05740
gene id: 523841:E6P09_RS05740
uniprot id: I3R204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS01295
gene id: 523841:E6P09_RS01295
uniprot id: I3R6B2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS05045
gene id: 523841:E6P09_RS05045
uniprot id: I3R1M1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

523841:E6P09 RS04680
gene id: 523841:E6P09_RS04680
uniprot id: I3R1E7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS01980
gene id: 523841:E6P09_RS01980
uniprot id: I3R5Y0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS07300
gene id: 523841:E6P09_RS07300
uniprot id: I3R2W6
names: Similarity
messages: Belongs to the peptidase S49 family.

523841:E6P09 RS18865
gene id: 523841:E6P09_RS18865
uniprot id: I3R8Y7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS14900
gene id: 523841:E6P09_RS14900
uniprot id: I3R754
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS07975
gene id: 523841:E6P09_RS07975
uniprot id: I3R394
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS11530
gene id: 523841:E6P09_RS11530
uniprot id: Q02234
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpI family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC and GvpO.
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS04605
gene id: 523841:E6P09_RS04605
uniprot id: I3R1D2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

523841:E6P09 RS01045
gene id: 523841:E6P09_RS01045
uniprot id: I3R6G0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

523841:E6P09 RS13010
gene id: 523841:E6P09_RS13010
uniprot id: I3R870
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

523841:E6P09 RS13420
gene id: 523841:E6P09_RS13420
uniprot id: I3R7Y6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523841:E6P09 RS15470
gene id: 523841:E6P09_RS15470
uniprot id: I3RA82
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

523841:E6P09 RS03740
gene id: 523841:E6P09_RS03740
uniprot id: I3R0W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523841:E6P09 RS06135
gene id: 523841:E6P09_RS06135
uniprot id: I3R283
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

523841:E6P09 RS00590
gene id: 523841:E6P09_RS00590
uniprot id: M0IUG4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS12110
gene id: 523841:E6P09_RS12110
uniprot id: I3R5L0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS06200
gene id: 523841:E6P09_RS06200
uniprot id: I3R295
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08240
gene id: 523841:E6P09_RS08240
uniprot id: I3R3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS02470
gene id: 523841:E6P09_RS02470
uniprot id: I3R5N2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

523841:E6P09 RS08565
gene id: 523841:E6P09_RS08565
uniprot id: I3R3L4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

523841:E6P09 RS08720
gene id: 523841:E6P09_RS08720
uniprot id: I3R3P6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

523841:E6P09 RS03325
gene id: 523841:E6P09_RS03325
uniprot id: I3R0N0
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

523841:E6P09 RS17780
gene id: 523841:E6P09_RS17780
uniprot id: I3R9V3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS14935
gene id: 523841:E6P09_RS14935
uniprot id: I3R746
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS14150
gene id: 523841:E6P09_RS14150
uniprot id: I3R7J3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

523841:E6P09 RS17765
gene id: 523841:E6P09_RS17765
uniprot id: I3R9V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS02655
gene id: 523841:E6P09_RS02655
uniprot id: I3R8P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

523841:E6P09 RS16100
gene id: 523841:E6P09_RS16100
uniprot id: I3RB79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS16215
gene id: 523841:E6P09_RS16215
uniprot id: M0IKE1
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

523841:E6P09 RS02025
gene id: 523841:E6P09_RS02025
uniprot id: I3R5X0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS15360
gene id: 523841:E6P09_RS15360
uniprot id: I3RAA6
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS06850
gene id: 523841:E6P09_RS06850
uniprot id: I3R2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

523841:E6P09 RS04055
gene id: 523841:E6P09_RS04055
uniprot id: I3R121
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

523841:E6P09 RS03065
gene id: 523841:E6P09_RS03065
uniprot id: I3R8Y0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

523841:E6P09 RS00955
gene id: 523841:E6P09_RS00955
uniprot id: I3R6H7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03735
gene id: 523841:E6P09_RS03735
uniprot id: M0J542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

523841:E6P09 RS04015
gene id: 523841:E6P09_RS04015
uniprot id: I3R113
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS05260
gene id: 523841:E6P09_RS05260
uniprot id: I3R1R3
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

523841:E6P09 RS02670
gene id: 523841:E6P09_RS02670
uniprot id: I3R8Q2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

523841:E6P09 RS05220
gene id: 523841:E6P09_RS05220
uniprot id: I3R1Q5
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

523841:E6P09 RS11610
gene id: 523841:E6P09_RS11610
uniprot id: I3R5B3
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

523841:E6P09 RS08325
gene id: 523841:E6P09_RS08325
uniprot id: I3R3G4
names: Function
messages: Part of a potassium transport system.

523841:E6P09 RS07915
gene id: 523841:E6P09_RS07915
uniprot id: I3R382
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS08170
gene id: 523841:E6P09_RS08170
uniprot id: I3R3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

523841:E6P09 RS11130
gene id: 523841:E6P09_RS11130
uniprot id: I3R515
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

523841:E6P09 RS17875
gene id: 523841:E6P09_RS17875
uniprot id: I3R9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS13900
gene id: 523841:E6P09_RS13900
uniprot id: I3R7P7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

523841:E6P09 RS13750
gene id: 523841:E6P09_RS13750
uniprot id: I3R7S4
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

523841:E6P09 RS05735
gene id: 523841:E6P09_RS05735
uniprot id: I3R203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS01670
gene id: 523841:E6P09_RS01670
uniprot id: I3R637
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Catalyzes the reduction of nitrite to ammonium in the nitrate assimilation pathway, using ferredoxin as the electron donor. Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.
messages: Enzyme stability and activity depend upon the salt concentration.
messages: Inhibited by cyanide and azide.
messages: Monomer.
messages: Repressed by the presence of ammonium as nitrogen source.

523841:E6P09 RS12630
gene id: 523841:E6P09_RS12630
uniprot id: I3R8E1
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

523841:E6P09 RS05805
gene id: 523841:E6P09_RS05805
uniprot id: I3R217
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

523841:E6P09 RS00865
gene id: 523841:E6P09_RS00865
uniprot id: I3R6J3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS04080
gene id: 523841:E6P09_RS04080
uniprot id: I3R125
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

523841:E6P09 RS02600
gene id: 523841:E6P09_RS02600
uniprot id: I3R8N8
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

523841:E6P09 RS09830
gene id: 523841:E6P09_RS09830
uniprot id: I3R4B2
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

523841:E6P09 RS02835
gene id: 523841:E6P09_RS02835
uniprot id: I3R8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

523841:E6P09 RS18045
gene id: 523841:E6P09_RS18045
uniprot id: I3RA07
names: Subunit
messages: Homotrimer.

523841:E6P09 RS07450
gene id: 523841:E6P09_RS07450
uniprot id: I3R2Z7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11330
gene id: 523841:E6P09_RS11330
uniprot id: I3R556
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS15155
gene id: 523841:E6P09_RS15155
uniprot id: I3RAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS00995
gene id: 523841:E6P09_RS00995
uniprot id: I3R6G9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

523841:E6P09 RS06415
gene id: 523841:E6P09_RS06415
uniprot id: I3R2D7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS12350
gene id: 523841:E6P09_RS12350
uniprot id: I3R8J7
names: Similarity
messages: Belongs to the Nth/MutY family.

523841:E6P09 RS07060
gene id: 523841:E6P09_RS07060
uniprot id: I3R2R8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome

523841:E6P09 RS08950
gene id: 523841:E6P09_RS08950
uniprot id: I3R3T9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

523841:E6P09 RS12010
gene id: 523841:E6P09_RS12010
uniprot id: I3R5J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS17460
gene id: 523841:E6P09_RS17460
uniprot id: I3R9N2
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cell membrane
messages: Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.
messages: The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. Proposed Rieske subunit involved in a protonmotive Q-cycle mechanism-based electron transfer electrons to the beta subunit.

523841:E6P09 RS08520
gene id: 523841:E6P09_RS08520
uniprot id: I3R3K5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

523841:E6P09 RS00635
gene id: 523841:E6P09_RS00635
uniprot id: I3R6P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

523841:E6P09 RS00170
gene id: 523841:E6P09_RS00170
uniprot id: I3R6X8
names: Similarity
messages: Belongs to the group II decarboxylase family.

523841:E6P09 RS08405
gene id: 523841:E6P09_RS08405
uniprot id: I3R3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS11520
gene id: 523841:E6P09_RS11520
uniprot id: Q02232
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpG family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es).
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS08395
gene id: 523841:E6P09_RS08395
uniprot id: I3R3H9
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

523841:E6P09 RS09110
gene id: 523841:E6P09_RS09110
uniprot id: I3R3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

523841:E6P09 RS03280
gene id: 523841:E6P09_RS03280
uniprot id: I3R0M1
names: Similarity
messages: Belongs to the cytochrome P450 family.

523841:E6P09 RS12245
gene id: 523841:E6P09_RS12245
uniprot id: I3R8L7
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

523841:E6P09 RS04750
gene id: 523841:E6P09_RS04750
uniprot id: I3R1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS03950
gene id: 523841:E6P09_RS03950
uniprot id: I3R101
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

523841:E6P09 RS06845
gene id: 523841:E6P09_RS06845
uniprot id: I3R2M6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

523841:E6P09 RS00715
gene id: 523841:E6P09_RS00715
uniprot id: M0IUD4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

523841:E6P09 RS05125
gene id: 523841:E6P09_RS05125
uniprot id: I3R1N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS06290
gene id: 523841:E6P09_RS06290
uniprot id: I3R2B2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

523841:E6P09 RS01340
gene id: 523841:E6P09_RS01340
uniprot id: I3R6A4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

523841:E6P09 RS12930
gene id: 523841:E6P09_RS12930
uniprot id: I3R886
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523841:E6P09 RS09825
gene id: 523841:E6P09_RS09825
uniprot id: I3R4B1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

523841:E6P09 RS13885
gene id: 523841:E6P09_RS13885
uniprot id: I3R7Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS02235
gene id: 523841:E6P09_RS02235
uniprot id: I3R5S7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS17640
gene id: 523841:E6P09_RS17640
uniprot id: I3R9S2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

523841:E6P09 RS03135
gene id: 523841:E6P09_RS03135
uniprot id: I3R0J3
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

523841:E6P09 RS12820
gene id: 523841:E6P09_RS12820
uniprot id: I3R8A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

523841:E6P09 RS09435
gene id: 523841:E6P09_RS09435
uniprot id: I3R438
names: Similarity
messages: Belongs to the UPF0047 family.

523841:E6P09 RS03730
gene id: 523841:E6P09_RS03730
uniprot id: I3R0W1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

523841:E6P09 RS11280
gene id: 523841:E6P09_RS11280
uniprot id: M0J9R5
uniprot id: Q9HHB9
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

523841:E6P09 RS14395
gene id: 523841:E6P09_RS14395
uniprot id: I3R7F0
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS03390
gene id: 523841:E6P09_RS03390
uniprot id: I3R0P2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS11060
gene id: 523841:E6P09_RS11060
uniprot id: I3R501
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

523841:E6P09 RS13895
gene id: 523841:E6P09_RS13895
uniprot id: I3R7P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

523841:E6P09 RS07970
gene id: 523841:E6P09_RS07970
uniprot id: I3R393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

523841:E6P09 RS13660
gene id: 523841:E6P09_RS13660
uniprot id: I3R7U1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

523841:E6P09 RS00760
gene id: 523841:E6P09_RS00760
uniprot id: I3R6L5
names: Cofactor
messages: Binds 1 copper ion per subunit.

523841:E6P09 RS10290
gene id: 523841:E6P09_RS10290
uniprot id: I3R4K2
names: Similarity
messages: Belongs to the UPF0145 family.

523841:E6P09 RS03750
gene id: 523841:E6P09_RS03750
uniprot id: I3R0W5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

523841:E6P09 RS14850
gene id: 523841:E6P09_RS14850
uniprot id: I3R764
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

523841:E6P09 RS11500
gene id: 523841:E6P09_RS11500
uniprot id: M0J8S6
uniprot id: P23761
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell (PubMed:1703266, PubMed:1282192, PubMed:21542854). This gene replaces p-gvpA of H.salinarum very poorly, only about 1% of GVs are formed; the few gas vesicles formed are quite strong with a very high critical collapse pressure (CCP) of 0.213 MPa (PubMed:12167531).
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: Infrared spectra studies suggest the major structural elements are 47% alpha-helix and 25% antiparallel beta-strands; it is thought the beta-strands make the hydrophobic interior surface (PubMed:21542854).
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle (By similarity). Modeled as antiparallel homodimers (PubMed:21542854).
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.
messages: Transcription is controlled by the GvpD-GvpE pair (PubMed:8757736, PubMed:12864859) (Probable). Transcripts are maximal at the beginning of stationary phase. Gas vesicle formation is maximally induced in stationary phase when grown in 20-25% total salt (NaCl, MgSO(4), KCl) (at protein level) (PubMed:1703266, PubMed:1282192, PubMed:8757736). Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736, PubMed:12864859). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).

523841:E6P09 RS14435
gene id: 523841:E6P09_RS14435
uniprot id: I3R7E3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS16200
gene id: 523841:E6P09_RS16200
uniprot id: I3RB56
names: Subcellular Location Annotation
messages: Cytoplasm

523841:E6P09 RS10685
gene id: 523841:E6P09_RS10685
uniprot id: I3R4S7
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523841:E6P09 RS00130
gene id: 523841:E6P09_RS00130
uniprot id: I3R6Y5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

523841:E6P09 RS07715
gene id: 523841:E6P09_RS07715
uniprot id: I3R343
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10145
gene id: 523841:E6P09_RS10145
uniprot id: I3R4H3
names: Similarity
messages: Belongs to the FUN14 family.

523841:E6P09 RS17445
gene id: 523841:E6P09_RS17445
uniprot id: A0A059TYV5
uniprot id: I3R9M9
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: By nitrate.
messages: Cell membrane
messages: Exported by the Tat system.
messages: Inhibited by cyanide, azide and antimycin A. Enzyme stability is not dependent on salt concentration.
messages: Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.
messages: The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The alpha chain is the actual site of nitrate reduction.

523841:E6P09 RS12830
gene id: 523841:E6P09_RS12830
uniprot id: I3R8A5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

523841:E6P09 RS03870
gene id: 523841:E6P09_RS03870
uniprot id: I3R0Y5
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

523841:E6P09 RS15065
gene id: 523841:E6P09_RS15065
uniprot id: I3R722
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

523841:E6P09 RS12270
gene id: 523841:E6P09_RS12270
uniprot id: I3R8L2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

523841:E6P09 RS06065
gene id: 523841:E6P09_RS06065
uniprot id: I3R270
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

523841:E6P09 RS05000
gene id: 523841:E6P09_RS05000
uniprot id: I3R1L2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS09160
gene id: 523841:E6P09_RS09160
uniprot id: I3R3Y3
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

523841:E6P09 RS00720
gene id: 523841:E6P09_RS00720
uniprot id: I3R6M3
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS19100
gene id: 523841:E6P09_RS19100
uniprot id: I3R934
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS19330
gene id: 523841:E6P09_RS19330
uniprot id: I3R977
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS14550
gene id: 523841:E6P09_RS14550
uniprot id: I3R7C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523841:E6P09 RS04650
gene id: 523841:E6P09_RS04650
uniprot id: I3R1E1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

523841:E6P09 RS17880
gene id: 523841:E6P09_RS17880
uniprot id: I3R9X0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS01190
gene id: 523841:E6P09_RS01190
uniprot id: I3R6D1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523841:E6P09 RS16955
gene id: 523841:E6P09_RS16955
uniprot id: I3RAP1
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS04185
gene id: 523841:E6P09_RS04185
uniprot id: I3R146
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

523841:E6P09 RS12450
gene id: 523841:E6P09_RS12450
uniprot id: I3R8H7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

523841:E6P09 RS08010
gene id: 523841:E6P09_RS08010
uniprot id: I3R3A2
names: Similarity
messages: Belongs to the peptidase S8 family.

523841:E6P09 RS12625
gene id: 523841:E6P09_RS12625
uniprot id: I3R8E2
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

523841:E6P09 RS10240
gene id: 523841:E6P09_RS10240
uniprot id: I3R4J2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

523841:E6P09 RS16905
gene id: 523841:E6P09_RS16905
uniprot id: I3RAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523841:E6P09 RS01360
gene id: 523841:E6P09_RS01360
uniprot id: I3R6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

523841:E6P09 RS04180
gene id: 523841:E6P09_RS04180
uniprot id: I3R145
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

523841:E6P09 RS10330
gene id: 523841:E6P09_RS10330
uniprot id: I3R4K9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

523841:E6P09 RS11325
gene id: 523841:E6P09_RS11325
uniprot id: I3R555
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523841:E6P09 RS03625
gene id: 523841:E6P09_RS03625
uniprot id: I3R0U0
names: Similarity
messages: Belongs to the UPF0175 family.

523841:E6P09 RS16580
gene id: 523841:E6P09_RS16580
uniprot id: I3RAX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

523841:E6P09 RS06770
gene id: 523841:E6P09_RS06770
uniprot id: I3R2L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

523841:E6P09 RS08955
gene id: 523841:E6P09_RS08955
uniprot id: I3R3U0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

523841:E6P09 RS18225
gene id: 523841:E6P09_RS18225
uniprot id: I3RA46
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS05690
gene id: 523841:E6P09_RS05690
uniprot id: I3R1Z5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

523841:E6P09 RS06230
gene id: 523841:E6P09_RS06230
uniprot id: I3R2A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

523841:E6P09 RS10005
gene id: 523841:E6P09_RS10005
uniprot id: M0J7P7
names: Subcellular Location Annotation
messages: Membrane

523841:E6P09 RS10415
gene id: 523841:E6P09_RS10415
uniprot id: I3R4M6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523841:E6P09 RS08260
gene id: 523841:E6P09_RS08260
uniprot id: I3R3F0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523841:E6P09 RS16885
gene id: 523841:E6P09_RS16885
uniprot id: I3RAQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523841:E6P09 RS01170
gene id: 523841:E6P09_RS01170
uniprot id: I3R6D5
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

523841:E6P09 RS11545
gene id: 523841:E6P09_RS11545
uniprot id: M0J9K1
uniprot id: Q02237
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpF/GvpL family.
messages: Encoded in a 14-gene locus called mc-vac.
messages: Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.
messages: Gas vesicle
messages: GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC, GvpN and GvpO.
messages: Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).
messages: Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).
messages: Vesicle

523841:E6P09 RS07030
gene id: 523841:E6P09_RS07030
uniprot id: I3R2R2
names: Similarity
messages: Belongs to the peptidase S9C family.

523841:E6P09 RS03915
gene id: 523841:E6P09_RS03915
uniprot id: I3R0Z4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

523841:E6P09 RS13915
gene id: 523841:E6P09_RS13915
uniprot id: I3R7P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

523841:E6P09 RS12510
gene id: 523841:E6P09_RS12510
uniprot id: I3R8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.