523794:LEBU RS09050
gene id: 523794:LEBU_RS09050
uniprot id: C7NC17
names: Similarity
messages: Belongs to the glutamine synthetase family.

523794:LEBU RS07560
gene id: 523794:LEBU_RS07560
uniprot id: C7NB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

523794:LEBU RS03550
gene id: 523794:LEBU_RS03550
uniprot id: C7N8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS10115
gene id: 523794:LEBU_RS10115
uniprot id: C7ND23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS06725
gene id: 523794:LEBU_RS06725
uniprot id: C7NAR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

523794:LEBU RS04225
gene id: 523794:LEBU_RS04225
uniprot id: C7N9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

523794:LEBU RS11120
gene id: 523794:LEBU_RS11120
uniprot id: C7NDW1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

523794:LEBU RS07165
gene id: 523794:LEBU_RS07165
uniprot id: C7NAZ8
names: Similarity
messages: Belongs to the YggT family.

523794:LEBU RS11115
gene id: 523794:LEBU_RS11115
uniprot id: C7NDW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

523794:LEBU RS04375
gene id: 523794:LEBU_RS04375
uniprot id: C7N9E6
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

523794:LEBU RS06705
gene id: 523794:LEBU_RS06705
uniprot id: C7NAR2
names: Similarity
messages: Belongs to the peptidase M18 family.

523794:LEBU RS06835
gene id: 523794:LEBU_RS06835
uniprot id: C7NAT8
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01275
gene id: 523794:LEBU_RS01275
uniprot id: C7NDL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

523794:LEBU RS04925
gene id: 523794:LEBU_RS04925
uniprot id: C7N9Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523794:LEBU RS09340
gene id: 523794:LEBU_RS09340
uniprot id: C7NC70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

523794:LEBU RS08805
gene id: 523794:LEBU_RS08805
uniprot id: C7NBX0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

523794:LEBU RS08940
gene id: 523794:LEBU_RS08940
uniprot id: C7NBZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

523794:LEBU RS03205
gene id: 523794:LEBU_RS03205
uniprot id: C7N8R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

523794:LEBU RS00375
gene id: 523794:LEBU_RS00375
uniprot id: C7NCT9
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

523794:LEBU RS02440
gene id: 523794:LEBU_RS02440
uniprot id: C7NEN0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS01560
gene id: 523794:LEBU_RS01560
uniprot id: C7NE29
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS00480
gene id: 523794:LEBU_RS00480
uniprot id: C7NCV8
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

523794:LEBU RS03535
gene id: 523794:LEBU_RS03535
uniprot id: C7N8X8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS07555
gene id: 523794:LEBU_RS07555
uniprot id: C7NB74
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS03995
gene id: 523794:LEBU_RS03995
uniprot id: C7N970
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

523794:LEBU RS09645
gene id: 523794:LEBU_RS09645
uniprot id: C7NCG3
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02905
gene id: 523794:LEBU_RS02905
uniprot id: C7N8K1
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

523794:LEBU RS03470
gene id: 523794:LEBU_RS03470
uniprot id: C7N8W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

523794:LEBU RS05470
gene id: 523794:LEBU_RS05470
uniprot id: C7NA19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

523794:LEBU RS11305
gene id: 523794:LEBU_RS11305
uniprot id: C7NDZ7
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS06535
gene id: 523794:LEBU_RS06535
uniprot id: C7NAM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

523794:LEBU RS11485
gene id: 523794:LEBU_RS11485
uniprot id: C7NEF5
names: Subcellular Location Annotation
messages: Cytoplasm

523794:LEBU RS05210
gene id: 523794:LEBU_RS05210
uniprot id: C7N9W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

523794:LEBU RS09850
gene id: 523794:LEBU_RS09850
uniprot id: C7NCK4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

523794:LEBU RS03405
gene id: 523794:LEBU_RS03405
uniprot id: C7N8V2
names: Similarity
messages: Belongs to the RutC family.

523794:LEBU RS04280
gene id: 523794:LEBU_RS04280
uniprot id: C7N9C7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

523794:LEBU RS09100
gene id: 523794:LEBU_RS09100
uniprot id: C7NC27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

523794:LEBU RS02975
gene id: 523794:LEBU_RS02975
uniprot id: C7N8L5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

523794:LEBU RS03875
gene id: 523794:LEBU_RS03875
uniprot id: C7N946
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

523794:LEBU RS02970
gene id: 523794:LEBU_RS02970
uniprot id: C7N8L4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

523794:LEBU RS05030
gene id: 523794:LEBU_RS05030
uniprot id: C7N9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS00765
gene id: 523794:LEBU_RS00765
uniprot id: C7ND10
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

523794:LEBU RS10155
gene id: 523794:LEBU_RS10155
uniprot id: C7ND31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

523794:LEBU RS01255
gene id: 523794:LEBU_RS01255
uniprot id: C7NDK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

523794:LEBU RS07880
gene id: 523794:LEBU_RS07880
uniprot id: C7NBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

523794:LEBU RS07445
gene id: 523794:LEBU_RS07445
uniprot id: C7NB51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

523794:LEBU RS06890
gene id: 523794:LEBU_RS06890
uniprot id: C7NAU9
names: Similarity
messages: Belongs to the UPF0102 family.

523794:LEBU RS07610
gene id: 523794:LEBU_RS07610
uniprot id: C7NB84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS08545
gene id: 523794:LEBU_RS08545
uniprot id: C7NBR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

523794:LEBU RS02845
gene id: 523794:LEBU_RS02845
uniprot id: C7N8I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS00750
gene id: 523794:LEBU_RS00750
uniprot id: C7ND07
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

523794:LEBU RS04145
gene id: 523794:LEBU_RS04145
uniprot id: C7N9A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

523794:LEBU RS01745
gene id: 523794:LEBU_RS01745
uniprot id: C7NE66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

523794:LEBU RS00315
gene id: 523794:LEBU_RS00315
uniprot id: C7NCS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

523794:LEBU RS08885
gene id: 523794:LEBU_RS08885
uniprot id: C7NBY6
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

523794:LEBU RS01330
gene id: 523794:LEBU_RS01330
uniprot id: C7NDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS01115
gene id: 523794:LEBU_RS01115
uniprot id: C7NDH6
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS09410
gene id: 523794:LEBU_RS09410
uniprot id: C7NC83
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

523794:LEBU RS06540
gene id: 523794:LEBU_RS06540
uniprot id: C7NAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

523794:LEBU RS03600
gene id: 523794:LEBU_RS03600
uniprot id: C7N8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

523794:LEBU RS03360
gene id: 523794:LEBU_RS03360
uniprot id: C7N8U3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

523794:LEBU RS02480
gene id: 523794:LEBU_RS02480
uniprot id: C7NEN8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

523794:LEBU RS11480
gene id: 523794:LEBU_RS11480
uniprot id: C7NEF4
names: Subcellular Location Annotation
messages: Cytoplasm

523794:LEBU RS08340
gene id: 523794:LEBU_RS08340
uniprot id: C7NBN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

523794:LEBU RS01570
gene id: 523794:LEBU_RS01570
uniprot id: C7NE31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class B bacterial acid phosphatase family.
messages: Homotetramer.
messages: Periplasm

523794:LEBU RS03290
gene id: 523794:LEBU_RS03290
uniprot id: C7N8S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

523794:LEBU RS06470
gene id: 523794:LEBU_RS06470
uniprot id: C7NAL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

523794:LEBU RS05200
gene id: 523794:LEBU_RS05200
uniprot id: C7N9W2
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

523794:LEBU RS07615
gene id: 523794:LEBU_RS07615
uniprot id: C7NB85
names: Similarity
messages: Belongs to the YjdM family.

523794:LEBU RS10760
gene id: 523794:LEBU_RS10760
uniprot id: C7NDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

523794:LEBU RS01700
gene id: 523794:LEBU_RS01700
uniprot id: C7NE56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

523794:LEBU RS04275
gene id: 523794:LEBU_RS04275
uniprot id: C7N9C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

523794:LEBU RS03970
gene id: 523794:LEBU_RS03970
uniprot id: C7N965
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

523794:LEBU RS11455
gene id: 523794:LEBU_RS11455
uniprot id: C7NEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS09115
gene id: 523794:LEBU_RS09115
uniprot id: C7NC30
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02640
gene id: 523794:LEBU_RS02640
uniprot id: C7NES0
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

523794:LEBU RS03125
gene id: 523794:LEBU_RS03125
uniprot id: C7N8P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

523794:LEBU RS02395
gene id: 523794:LEBU_RS02395
uniprot id: C7NEM1
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

523794:LEBU RS01325
gene id: 523794:LEBU_RS01325
uniprot id: C7NDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS09125
gene id: 523794:LEBU_RS09125
uniprot id: C7NC32
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS06465
gene id: 523794:LEBU_RS06465
uniprot id: C7NAL5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

523794:LEBU RS08250
gene id: 523794:LEBU_RS08250
uniprot id: C7NBL2
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

523794:LEBU RS00250
gene id: 523794:LEBU_RS00250
uniprot id: C7NCR5
names: Similarity
messages: Belongs to the UPF0236 family.

523794:LEBU RS04395
gene id: 523794:LEBU_RS04395
uniprot id: C7N9F0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS02420
gene id: 523794:LEBU_RS02420
uniprot id: C7NEM6
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

523794:LEBU RS02110
gene id: 523794:LEBU_RS02110
uniprot id: C7NEH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS08450
gene id: 523794:LEBU_RS08450
uniprot id: C7NBQ1
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

523794:LEBU RS03610
gene id: 523794:LEBU_RS03610
uniprot id: C7N8Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

523794:LEBU RS06210
gene id: 523794:LEBU_RS06210
uniprot id: C7NAG3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

523794:LEBU RS09140
gene id: 523794:LEBU_RS09140
uniprot id: C7NC35
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

523794:LEBU RS03370
gene id: 523794:LEBU_RS03370
uniprot id: C7N8U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

523794:LEBU RS04095
gene id: 523794:LEBU_RS04095
uniprot id: C7N990
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

523794:LEBU RS10515
gene id: 523794:LEBU_RS10515
uniprot id: C7ND90
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS09495
gene id: 523794:LEBU_RS09495
uniprot id: C7NCD5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

523794:LEBU RS09940
gene id: 523794:LEBU_RS09940
uniprot id: C7NCM1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

523794:LEBU RS11070
gene id: 523794:LEBU_RS11070
uniprot id: C7NDV1
names: Similarity
messages: Belongs to the leucine-binding protein family.

523794:LEBU RS03545
gene id: 523794:LEBU_RS03545
uniprot id: C7N8Y0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS01285
gene id: 523794:LEBU_RS01285
uniprot id: C7NDL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

523794:LEBU RS07045
gene id: 523794:LEBU_RS07045
uniprot id: C7NAX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

523794:LEBU RS09375
gene id: 523794:LEBU_RS09375
uniprot id: C7NC77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

523794:LEBU RS00310
gene id: 523794:LEBU_RS00310
uniprot id: C7NCS6
names: Subcellular Location Annotation
messages: Bacterial microcompartment

523794:LEBU RS07030
gene id: 523794:LEBU_RS07030
uniprot id: C7NAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

523794:LEBU RS03965
gene id: 523794:LEBU_RS03965
uniprot id: C7N964
names: Similarity
messages: Belongs to the BMP lipoprotein family.

523794:LEBU RS05965
gene id: 523794:LEBU_RS05965
uniprot id: C7NAB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

523794:LEBU RS05280
gene id: 523794:LEBU_RS05280
uniprot id: C7N9X8
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS10925
gene id: 523794:LEBU_RS10925
uniprot id: C7NDT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

523794:LEBU RS07855
gene id: 523794:LEBU_RS07855
uniprot id: C7NBD4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

523794:LEBU RS10135
gene id: 523794:LEBU_RS10135
uniprot id: C7ND27
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

523794:LEBU RS04435
gene id: 523794:LEBU_RS04435
uniprot id: C7N9F8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

523794:LEBU RS08660
gene id: 523794:LEBU_RS08660
uniprot id: C7NBU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

523794:LEBU RS07735
gene id: 523794:LEBU_RS07735
uniprot id: C7NBA9
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

523794:LEBU RS03220
gene id: 523794:LEBU_RS03220
uniprot id: C7N8R3
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

523794:LEBU RS00880
gene id: 523794:LEBU_RS00880
uniprot id: C7NDD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS03105
gene id: 523794:LEBU_RS03105
uniprot id: C7N8P0
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS00795
gene id: 523794:LEBU_RS00795
uniprot id: C7ND15
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS01770
gene id: 523794:LEBU_RS01770
uniprot id: C7NE71
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

523794:LEBU RS03410
gene id: 523794:LEBU_RS03410
uniprot id: C7N8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

523794:LEBU RS08150
gene id: 523794:LEBU_RS08150
uniprot id: C7NBJ3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

523794:LEBU RS09620
gene id: 523794:LEBU_RS09620
uniprot id: C7NCF8
names: Similarity
messages: Belongs to the thioredoxin family.

523794:LEBU RS04005
gene id: 523794:LEBU_RS04005
uniprot id: C7N972
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

523794:LEBU RS05245
gene id: 523794:LEBU_RS05245
uniprot id: C7N9X1
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

523794:LEBU RS01855
gene id: 523794:LEBU_RS01855
uniprot id: C7NE88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523794:LEBU RS09770
gene id: 523794:LEBU_RS09770
uniprot id: C7NCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

523794:LEBU RS01435
gene id: 523794:LEBU_RS01435
uniprot id: C7NDN7
names: Similarity
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

523794:LEBU RS03885
gene id: 523794:LEBU_RS03885
uniprot id: C7N948
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS03670
gene id: 523794:LEBU_RS03670
uniprot id: C7N905
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

523794:LEBU RS00455
gene id: 523794:LEBU_RS00455
uniprot id: C7NCV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

523794:LEBU RS01195
gene id: 523794:LEBU_RS01195
uniprot id: C7NDJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

523794:LEBU RS02890
gene id: 523794:LEBU_RS02890
uniprot id: C7N8J8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS03815
gene id: 523794:LEBU_RS03815
uniprot id: C7N934
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523794:LEBU RS02340
gene id: 523794:LEBU_RS02340
uniprot id: C7NEL0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523794:LEBU RS05105
gene id: 523794:LEBU_RS05105
uniprot id: C7N9U3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

523794:LEBU RS05115
gene id: 523794:LEBU_RS05115
uniprot id: C7N9U5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

523794:LEBU RS09260
gene id: 523794:LEBU_RS09260
uniprot id: C7NC53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS09480
gene id: 523794:LEBU_RS09480
uniprot id: C7NCD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS07400
gene id: 523794:LEBU_RS07400
uniprot id: C7NB42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

523794:LEBU RS06195
gene id: 523794:LEBU_RS06195
uniprot id: C7NAF9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

523794:LEBU RS01300
gene id: 523794:LEBU_RS01300
uniprot id: C7NDL5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

523794:LEBU RS07085
gene id: 523794:LEBU_RS07085
uniprot id: C7NAY3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

523794:LEBU RS01910
gene id: 523794:LEBU_RS01910
uniprot id: C7NE98
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

523794:LEBU RS02725
gene id: 523794:LEBU_RS02725
uniprot id: C7N8G7
names: Similarity
messages: Belongs to the peptidase C40 family.

523794:LEBU RS07425
gene id: 523794:LEBU_RS07425
uniprot id: C7NB47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

523794:LEBU RS08770
gene id: 523794:LEBU_RS08770
uniprot id: C7NBW4
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS04080
gene id: 523794:LEBU_RS04080
uniprot id: C7N987
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS01830
gene id: 523794:LEBU_RS01830
uniprot id: C7NE83
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

523794:LEBU RS08820
gene id: 523794:LEBU_RS08820
uniprot id: C7NBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

523794:LEBU RS01975
gene id: 523794:LEBU_RS01975
uniprot id: C7NEB1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

523794:LEBU RS04125
gene id: 523794:LEBU_RS04125
uniprot id: C7N996
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS09910
gene id: 523794:LEBU_RS09910
uniprot id: C7NCL5
names: Similarity
messages: Belongs to the UPF0145 family.

523794:LEBU RS10960
gene id: 523794:LEBU_RS10960
uniprot id: C7NDT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

523794:LEBU RS03075
gene id: 523794:LEBU_RS03075
uniprot id: C7N8N4
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS09135
gene id: 523794:LEBU_RS09135
uniprot id: C7NC34
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS08540
gene id: 523794:LEBU_RS08540
uniprot id: C7NBR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

523794:LEBU RS06000
gene id: 523794:LEBU_RS06000
uniprot id: C7NAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

523794:LEBU RS03595
gene id: 523794:LEBU_RS03595
uniprot id: C7N8Z0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523794:LEBU RS10510
gene id: 523794:LEBU_RS10510
uniprot id: C7ND89
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS10435
gene id: 523794:LEBU_RS10435
uniprot id: C7ND77
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS03880
gene id: 523794:LEBU_RS03880
uniprot id: C7N947
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

523794:LEBU RS01050
gene id: 523794:LEBU_RS01050
uniprot id: C7NDG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS07480
gene id: 523794:LEBU_RS07480
uniprot id: C7NB57
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

523794:LEBU RS04140
gene id: 523794:LEBU_RS04140
uniprot id: C7N999
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

523794:LEBU RS10285
gene id: 523794:LEBU_RS10285
uniprot id: C7ND52
names: Similarity
messages: Belongs to the peptidase S8 family.

523794:LEBU RS01525
gene id: 523794:LEBU_RS01525
uniprot id: C7NE22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS00450
gene id: 523794:LEBU_RS00450
uniprot id: C7NCV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

523794:LEBU RS06235
gene id: 523794:LEBU_RS06235
uniprot id: C7NAG9
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

523794:LEBU RS03415
gene id: 523794:LEBU_RS03415
uniprot id: C7N8V4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

523794:LEBU RS03265
gene id: 523794:LEBU_RS03265
uniprot id: C7N8S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

523794:LEBU RS11470
gene id: 523794:LEBU_RS11470
uniprot id: C7NEF2
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS00930
gene id: 523794:LEBU_RS00930
uniprot id: C7NDE6
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

523794:LEBU RS05635
gene id: 523794:LEBU_RS05635
uniprot id: C7NA51
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

523794:LEBU RS03940
gene id: 523794:LEBU_RS03940
uniprot id: C7N959
names: Similarity
messages: Belongs to the heat shock protein 70 family.

523794:LEBU RS09445
gene id: 523794:LEBU_RS09445
uniprot id: C7NC90
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02080
gene id: 523794:LEBU_RS02080
uniprot id: C7NED0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

523794:LEBU RS05755
gene id: 523794:LEBU_RS05755
uniprot id: C7NA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS00245
gene id: 523794:LEBU_RS00245
uniprot id: C7NCR4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523794:LEBU RS06485
gene id: 523794:LEBU_RS06485
uniprot id: C7NAL8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

523794:LEBU RS02715
gene id: 523794:LEBU_RS02715
uniprot id: C7N8G5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

523794:LEBU RS00640
gene id: 523794:LEBU_RS00640
uniprot id: C7NCY5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523794:LEBU RS01735
gene id: 523794:LEBU_RS01735
uniprot id: C7NE64
names: Similarity
messages: Belongs to the peptidase S41A family.

523794:LEBU RS07805
gene id: 523794:LEBU_RS07805
uniprot id: C7NBC4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

523794:LEBU RS11065
gene id: 523794:LEBU_RS11065
uniprot id: C7NDV0
names: Similarity
messages: Belongs to the leucine-binding protein family.

523794:LEBU RS11520
gene id: 523794:LEBU_RS11520
uniprot id: C7NEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

523794:LEBU RS05395
gene id: 523794:LEBU_RS05395
uniprot id: C7NA04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

523794:LEBU RS01730
gene id: 523794:LEBU_RS01730
uniprot id: C7NE63
names: Similarity
messages: Belongs to the TlyA family.

523794:LEBU RS03245
gene id: 523794:LEBU_RS03245
uniprot id: C7N8R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523794:LEBU RS05750
gene id: 523794:LEBU_RS05750
uniprot id: C7NA74
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

523794:LEBU RS07285
gene id: 523794:LEBU_RS07285
uniprot id: C7NB21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS05045
gene id: 523794:LEBU_RS05045
uniprot id: C7N9T1
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS09565
gene id: 523794:LEBU_RS09565
uniprot id: C7NCE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

523794:LEBU RS02610
gene id: 523794:LEBU_RS02610
uniprot id: C7NER4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

523794:LEBU RS03005
gene id: 523794:LEBU_RS03005
uniprot id: C7N8M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

523794:LEBU RS09545
gene id: 523794:LEBU_RS09545
uniprot id: C7NCE3
names: Similarity
messages: Belongs to the Dps family.

523794:LEBU RS07420
gene id: 523794:LEBU_RS07420
uniprot id: C7NB46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

523794:LEBU RS01170
gene id: 523794:LEBU_RS01170
uniprot id: C7NDI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

523794:LEBU RS02430
gene id: 523794:LEBU_RS02430
uniprot id: C7NEM8
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

523794:LEBU RS11185
gene id: 523794:LEBU_RS11185
uniprot id: C7NDX4
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

523794:LEBU RS02535
gene id: 523794:LEBU_RS02535
uniprot id: C7NEP9
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

523794:LEBU RS02135
gene id: 523794:LEBU_RS02135
uniprot id: C7NEH5
names: Similarity
messages: Belongs to the peptidase S11 family.

523794:LEBU RS01270
gene id: 523794:LEBU_RS01270
uniprot id: C7NDK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

523794:LEBU RS07985
gene id: 523794:LEBU_RS07985
uniprot id: C7NBG0
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

523794:LEBU RS02735
gene id: 523794:LEBU_RS02735
uniprot id: C7N8G9
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS07975
gene id: 523794:LEBU_RS07975
uniprot id: C7NBF8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS10010
gene id: 523794:LEBU_RS10010
uniprot id: C7NCN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS06790
gene id: 523794:LEBU_RS06790
uniprot id: C7NAS9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS09980
gene id: 523794:LEBU_RS09980
uniprot id: C7NCM9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

523794:LEBU RS05835
gene id: 523794:LEBU_RS05835
uniprot id: C7NA90
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

523794:LEBU RS08380
gene id: 523794:LEBU_RS08380
uniprot id: C7NBN8
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

523794:LEBU RS00495
gene id: 523794:LEBU_RS00495
uniprot id: C7NCW0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523794:LEBU RS09715
gene id: 523794:LEBU_RS09715
uniprot id: C7NCH7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

523794:LEBU RS09145
gene id: 523794:LEBU_RS09145
uniprot id: C7NC36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

523794:LEBU RS04055
gene id: 523794:LEBU_RS04055
uniprot id: C7N982
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

523794:LEBU RS00060
gene id: 523794:LEBU_RS00060
uniprot id: C7NCA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523794:LEBU RS01690
gene id: 523794:LEBU_RS01690
uniprot id: C7NE54
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

523794:LEBU RS02130
gene id: 523794:LEBU_RS02130
uniprot id: C7NEH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

523794:LEBU RS05845
gene id: 523794:LEBU_RS05845
uniprot id: C7NA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

523794:LEBU RS06910
gene id: 523794:LEBU_RS06910
uniprot id: C7NAV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

523794:LEBU RS03705
gene id: 523794:LEBU_RS03705
uniprot id: C7N912
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

523794:LEBU RS03030
gene id: 523794:LEBU_RS03030
uniprot id: C7N8M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523794:LEBU RS08255
gene id: 523794:LEBU_RS08255
uniprot id: C7NBL3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS00670
gene id: 523794:LEBU_RS00670
uniprot id: C7NCZ1
names: Similarity
messages: Belongs to the YciI family.

523794:LEBU RS01245
gene id: 523794:LEBU_RS01245
uniprot id: C7NDK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

523794:LEBU RS11080
gene id: 523794:LEBU_RS11080
uniprot id: C7NDV3
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS07565
gene id: 523794:LEBU_RS07565
uniprot id: C7NB76
names: Similarity
messages: Belongs to the YciI family.

523794:LEBU RS09680
gene id: 523794:LEBU_RS09680
uniprot id: C7NCH0
names: Similarity
messages: Belongs to the thioredoxin family.

523794:LEBU RS04210
gene id: 523794:LEBU_RS04210
uniprot id: C7N9B3
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

523794:LEBU RS01290
gene id: 523794:LEBU_RS01290
uniprot id: C7NDL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

523794:LEBU RS10315
gene id: 523794:LEBU_RS10315
uniprot id: C7ND58
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

523794:LEBU RS04020
gene id: 523794:LEBU_RS04020
uniprot id: C7N975
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

523794:LEBU RS04105
gene id: 523794:LEBU_RS04105
uniprot id: C7N992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523794:LEBU RS07900
gene id: 523794:LEBU_RS07900
uniprot id: C7NBE3
names: Similarity
messages: Belongs to the DEAD box helicase family.

523794:LEBU RS02315
gene id: 523794:LEBU_RS02315
uniprot id: C7NEK6
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS10185
gene id: 523794:LEBU_RS10185
uniprot id: C7ND38
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

523794:LEBU RS05275
gene id: 523794:LEBU_RS05275
uniprot id: C7N9X7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS06265
gene id: 523794:LEBU_RS06265
uniprot id: C7NAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

523794:LEBU RS00380
gene id: 523794:LEBU_RS00380
uniprot id: C7NCU0
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

523794:LEBU RS10635
gene id: 523794:LEBU_RS10635
uniprot id: C7NDB2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

523794:LEBU RS02785
gene id: 523794:LEBU_RS02785
uniprot id: C7N8H8
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

523794:LEBU RS02625
gene id: 523794:LEBU_RS02625
uniprot id: C7NER7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523794:LEBU RS09935
gene id: 523794:LEBU_RS09935
uniprot id: C7NCM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

523794:LEBU RS09955
gene id: 523794:LEBU_RS09955
uniprot id: C7NCM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

523794:LEBU RS06270
gene id: 523794:LEBU_RS06270
uniprot id: C7NAH6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

523794:LEBU RS07110
gene id: 523794:LEBU_RS07110
uniprot id: C7NAY8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

523794:LEBU RS03835
gene id: 523794:LEBU_RS03835
uniprot id: C7N938
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

523794:LEBU RS11165
gene id: 523794:LEBU_RS11165
uniprot id: C7NDX0
names: Similarity
messages: Belongs to the peptidase S8 family.

523794:LEBU RS08125
gene id: 523794:LEBU_RS08125
uniprot id: C7NBI8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

523794:LEBU RS03910
gene id: 523794:LEBU_RS03910
uniprot id: C7N953
names: Similarity
messages: Belongs to the peptidase C40 family.

523794:LEBU RS11530
gene id: 523794:LEBU_RS11530
uniprot id: C7NEG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

523794:LEBU RS02515
gene id: 523794:LEBU_RS02515
uniprot id: C7NEP5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

523794:LEBU RS06255
gene id: 523794:LEBU_RS06255
uniprot id: C7NAH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

523794:LEBU RS09130
gene id: 523794:LEBU_RS09130
uniprot id: C7NC33
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03915
gene id: 523794:LEBU_RS03915
uniprot id: C7N954
names: Similarity
messages: Belongs to the peptidase S8 family.

523794:LEBU RS01280
gene id: 523794:LEBU_RS01280
uniprot id: C7NDL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

523794:LEBU RS01695
gene id: 523794:LEBU_RS01695
uniprot id: C7NE55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

523794:LEBU RS00360
gene id: 523794:LEBU_RS00360
uniprot id: C7NCT6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the PduL family.
messages: Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices.
messages: Involved in 1,2-propanediol (1,2-PD) utilization within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
messages: There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer.

523794:LEBU RS02455
gene id: 523794:LEBU_RS02455
uniprot id: C7NEN3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

523794:LEBU RS06135
gene id: 523794:LEBU_RS06135
uniprot id: C7NAE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

523794:LEBU RS09320
gene id: 523794:LEBU_RS09320
uniprot id: C7NC66
names: Similarity
messages: Belongs to the peptidase S11 family.

523794:LEBU RS01070
gene id: 523794:LEBU_RS01070
uniprot id: C7NDG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

523794:LEBU RS00210
gene id: 523794:LEBU_RS00210
uniprot id: C7NCQ7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

523794:LEBU RS04950
gene id: 523794:LEBU_RS04950
uniprot id: C7N9R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

523794:LEBU RS09350
gene id: 523794:LEBU_RS09350
uniprot id: C7NC72
names: Similarity
messages: Belongs to the RNA polymerase subunit omega family.

523794:LEBU RS06740
gene id: 523794:LEBU_RS06740
uniprot id: C7NAR9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS10795
gene id: 523794:LEBU_RS10795
uniprot id: C7NDQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

523794:LEBU RS08315
gene id: 523794:LEBU_RS08315
uniprot id: C7NBM5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

523794:LEBU RS09110
gene id: 523794:LEBU_RS09110
uniprot id: C7NC29
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

523794:LEBU RS06360
gene id: 523794:LEBU_RS06360
uniprot id: C7NAJ4
names: Similarity
messages: Belongs to the nitroreductase family.

523794:LEBU RS03145
gene id: 523794:LEBU_RS03145
uniprot id: C7N8P8
names: Similarity
messages: Belongs to the peptidase A24 family.

523794:LEBU RS09045
gene id: 523794:LEBU_RS09045
uniprot id: C7NC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS11270
gene id: 523794:LEBU_RS11270
uniprot id: C7NDZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS04040
gene id: 523794:LEBU_RS04040
uniprot id: C7N979
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523794:LEBU RS09555
gene id: 523794:LEBU_RS09555
uniprot id: C7NCE5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

523794:LEBU RS02865
gene id: 523794:LEBU_RS02865
uniprot id: C7N8J3
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS10590
gene id: 523794:LEBU_RS10590
uniprot id: C7NDA3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

523794:LEBU RS05620
gene id: 523794:LEBU_RS05620
uniprot id: C7NA48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

523794:LEBU RS01520
gene id: 523794:LEBU_RS01520
uniprot id: C7NE21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

523794:LEBU RS09080
gene id: 523794:LEBU_RS09080
uniprot id: C7NC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS06050
gene id: 523794:LEBU_RS06050
uniprot id: C7NAD2
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

523794:LEBU RS11380
gene id: 523794:LEBU_RS11380
uniprot id: C7NED4
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

523794:LEBU RS04195
gene id: 523794:LEBU_RS04195
uniprot id: C7N9B0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

523794:LEBU RS03240
gene id: 523794:LEBU_RS03240
uniprot id: C7N8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

523794:LEBU RS00150
gene id: 523794:LEBU_RS00150
uniprot id: C7NCC5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

523794:LEBU RS06120
gene id: 523794:LEBU_RS06120
uniprot id: C7NAE4
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

523794:LEBU RS04860
gene id: 523794:LEBU_RS04860
uniprot id: C7N9P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

523794:LEBU RS09395
gene id: 523794:LEBU_RS09395
uniprot id: C7NC81
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

523794:LEBU RS03260
gene id: 523794:LEBU_RS03260
uniprot id: C7N8S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

523794:LEBU RS05560
gene id: 523794:LEBU_RS05560
uniprot id: C7NA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

523794:LEBU RS09745
gene id: 523794:LEBU_RS09745
uniprot id: C7NCI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

523794:LEBU RS00010
gene id: 523794:LEBU_RS00010
uniprot id: C7NC96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

523794:LEBU RS01670
gene id: 523794:LEBU_RS01670
uniprot id: C7NE50
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

523794:LEBU RS05850
gene id: 523794:LEBU_RS05850
uniprot id: C7NA93
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01185
gene id: 523794:LEBU_RS01185
uniprot id: C7NDJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

523794:LEBU RS00385
gene id: 523794:LEBU_RS00385
uniprot id: C7NCU1
names: Similarity
messages: Belongs to the EutP/PduV family.

523794:LEBU RS09215
gene id: 523794:LEBU_RS09215
uniprot id: C7NC44
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS04090
gene id: 523794:LEBU_RS04090
uniprot id: C7N989
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

523794:LEBU RS05940
gene id: 523794:LEBU_RS05940
uniprot id: C7NAB0
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS04410
gene id: 523794:LEBU_RS04410
uniprot id: C7N9F3
names: Similarity
messages: Belongs to the threonine synthase family.

523794:LEBU RS06140
gene id: 523794:LEBU_RS06140
uniprot id: C7NAE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

523794:LEBU RS06290
gene id: 523794:LEBU_RS06290
uniprot id: C7NAI0
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

523794:LEBU RS10310
gene id: 523794:LEBU_RS10310
uniprot id: C7ND57
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

523794:LEBU RS09625
gene id: 523794:LEBU_RS09625
uniprot id: C7NCF9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

523794:LEBU RS06455
gene id: 523794:LEBU_RS06455
uniprot id: C7NAL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

523794:LEBU RS06805
gene id: 523794:LEBU_RS06805
uniprot id: C7NAT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

523794:LEBU RS02655
gene id: 523794:LEBU_RS02655
uniprot id: C7NES3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS11490
gene id: 523794:LEBU_RS11490
uniprot id: C7NEF6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

523794:LEBU RS00460
gene id: 523794:LEBU_RS00460
uniprot id: C7NCV4
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02870
gene id: 523794:LEBU_RS02870
uniprot id: C7N8J4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

523794:LEBU RS09235
gene id: 523794:LEBU_RS09235
uniprot id: C7NC48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

523794:LEBU RS04835
gene id: 523794:LEBU_RS04835
uniprot id: C7N9N6
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

523794:LEBU RS09315
gene id: 523794:LEBU_RS09315
uniprot id: C7NC65
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

523794:LEBU RS01675
gene id: 523794:LEBU_RS01675
uniprot id: C7NE51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

523794:LEBU RS11360
gene id: 523794:LEBU_RS11360
uniprot id: C7NE08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

523794:LEBU RS00475
gene id: 523794:LEBU_RS00475
uniprot id: C7NCV7
names: Similarity
messages: Belongs to the CobH/CbiC family.

523794:LEBU RS08285
gene id: 523794:LEBU_RS08285
uniprot id: C7NBL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

523794:LEBU RS11275
gene id: 523794:LEBU_RS11275
uniprot id: C7NDZ1
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

523794:LEBU RS08595
gene id: 523794:LEBU_RS08595
uniprot id: C7NBS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523794:LEBU RS03605
gene id: 523794:LEBU_RS03605
uniprot id: C7N8Z2
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

523794:LEBU RS05600
gene id: 523794:LEBU_RS05600
uniprot id: C7NA45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

523794:LEBU RS05240
gene id: 523794:LEBU_RS05240
uniprot id: C7N9X0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

523794:LEBU RS11225
gene id: 523794:LEBU_RS11225
uniprot id: C7NDY1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

523794:LEBU RS10650
gene id: 523794:LEBU_RS10650
uniprot id: C7NDB5
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

523794:LEBU RS06710
gene id: 523794:LEBU_RS06710
uniprot id: C7NAR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

523794:LEBU RS07330
gene id: 523794:LEBU_RS07330
uniprot id: C7NB30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

523794:LEBU RS01785
gene id: 523794:LEBU_RS01785
uniprot id: C7NE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS08245
gene id: 523794:LEBU_RS08245
uniprot id: C7NBL1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

523794:LEBU RS06525
gene id: 523794:LEBU_RS06525
uniprot id: C7NAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

523794:LEBU RS05285
gene id: 523794:LEBU_RS05285
uniprot id: C7N9X9
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

523794:LEBU RS11220
gene id: 523794:LEBU_RS11220
uniprot id: C7NDY0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

523794:LEBU RS08665
gene id: 523794:LEBU_RS08665
uniprot id: C7NBU3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

523794:LEBU RS06715
gene id: 523794:LEBU_RS06715
uniprot id: C7NAR4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS06085
gene id: 523794:LEBU_RS06085
uniprot id: C7NAD8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

523794:LEBU RS07580
gene id: 523794:LEBU_RS07580
uniprot id: C7NB79
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

523794:LEBU RS09280
gene id: 523794:LEBU_RS09280
uniprot id: C7NC58
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

523794:LEBU RS09120
gene id: 523794:LEBU_RS09120
uniprot id: C7NC31
names: Similarity
messages: Belongs to the peptidase M16 family.

523794:LEBU RS00260
gene id: 523794:LEBU_RS00260
uniprot id: C7NCR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

523794:LEBU RS03210
gene id: 523794:LEBU_RS03210
uniprot id: C7N8R1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

523794:LEBU RS06795
gene id: 523794:LEBU_RS06795
uniprot id: C7NAT0
names: Similarity
messages: Belongs to the MlaA family.

523794:LEBU RS11505
gene id: 523794:LEBU_RS11505
uniprot id: C7NEF9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

523794:LEBU RS03500
gene id: 523794:LEBU_RS03500
uniprot id: C7N8X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

523794:LEBU RS02570
gene id: 523794:LEBU_RS02570
uniprot id: C7NEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

523794:LEBU RS06020
gene id: 523794:LEBU_RS06020
uniprot id: C7NAC6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS04940
gene id: 523794:LEBU_RS04940
uniprot id: C7N9Q9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

523794:LEBU RS05095
gene id: 523794:LEBU_RS05095
uniprot id: C7N9U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS05505
gene id: 523794:LEBU_RS05505
uniprot id: C7NA26
names: Similarity
messages: Belongs to the DprA/Smf family.

523794:LEBU RS09505
gene id: 523794:LEBU_RS09505
uniprot id: C7NCD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523794:LEBU RS04185
gene id: 523794:LEBU_RS04185
uniprot id: C7N9A8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS03625
gene id: 523794:LEBU_RS03625
uniprot id: C7N8Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS07155
gene id: 523794:LEBU_RS07155
uniprot id: C7NAZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

523794:LEBU RS01095
gene id: 523794:LEBU_RS01095
uniprot id: C7NDH2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS04260
gene id: 523794:LEBU_RS04260
uniprot id: C7N9C3
names: Similarity
messages: Belongs to the aspartokinase family.

523794:LEBU RS09845
gene id: 523794:LEBU_RS09845
uniprot id: C7NCK3
names: Similarity
messages: Belongs to the peptidase S66 family.

523794:LEBU RS02765
gene id: 523794:LEBU_RS02765
uniprot id: C7N8H4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

523794:LEBU RS03045
gene id: 523794:LEBU_RS03045
uniprot id: C7N8M8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

523794:LEBU RS07530
gene id: 523794:LEBU_RS07530
uniprot id: C7NB67
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Binds 1 NAD(+) per subunit.
messages: Homodimer.
messages: In vitro, readily hydrolyzes p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (pNPalphaG6P), a chromogenic analog of the phosphorylated isomers of sucrose. In vivo, is probably involved in the degradation of the 6-phosphate derivatives of the sucrose isomers trehalulose, turanose, maltulose and palatinose, catalyzing their hydrolysis into glucose 6-phosphate (G6P) and fructose, which allows the bacterium to use these sugars as energy sources for growth. Is not able to hydrolyze the C2 or C4 chromogenic stereomers (i.e. pNPalpha-mannopyranoside-6P and pNPalpha-galactopyranoside-6P, respectively).
messages: Induced by growth on the sucrose isomers trehalulose, turanose, maltulose and palatinose.

523794:LEBU RS11075
gene id: 523794:LEBU_RS11075
uniprot id: C7NDV2
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03275
gene id: 523794:LEBU_RS03275
uniprot id: C7N8S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

523794:LEBU RS02880
gene id: 523794:LEBU_RS02880
uniprot id: C7N8J6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

523794:LEBU RS01380
gene id: 523794:LEBU_RS01380
uniprot id: C7NDM5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

523794:LEBU RS08895
gene id: 523794:LEBU_RS08895
uniprot id: C7NBY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

523794:LEBU RS02055
gene id: 523794:LEBU_RS02055
uniprot id: C7NEC6
names: Similarity
messages: Belongs to the UPF0237 family.

523794:LEBU RS09640
gene id: 523794:LEBU_RS09640
uniprot id: C7NCG2
names: Similarity
messages: Belongs to the peptidase M29 family.

523794:LEBU RS02215
gene id: 523794:LEBU_RS02215
uniprot id: C7NEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

523794:LEBU RS02310
gene id: 523794:LEBU_RS02310
uniprot id: C7NEK5
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS08670
gene id: 523794:LEBU_RS08670
uniprot id: C7NBU4
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

523794:LEBU RS07315
gene id: 523794:LEBU_RS07315
uniprot id: C7NB27
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523794:LEBU RS08045
gene id: 523794:LEBU_RS08045
uniprot id: C7NBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS03195
gene id: 523794:LEBU_RS03195
uniprot id: C7N8Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

523794:LEBU RS00065
gene id: 523794:LEBU_RS00065
uniprot id: C7NCA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

523794:LEBU RS00530
gene id: 523794:LEBU_RS00530
uniprot id: C7NCW8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523794:LEBU RS01925
gene id: 523794:LEBU_RS01925
uniprot id: C7NEA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

523794:LEBU RS08240
gene id: 523794:LEBU_RS08240
uniprot id: C7NBL0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS02370
gene id: 523794:LEBU_RS02370
uniprot id: C7NEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

523794:LEBU RS04890
gene id: 523794:LEBU_RS04890
uniprot id: C7N9P8
names: Similarity
messages: Belongs to the MobA/MobL family.

523794:LEBU RS06300
gene id: 523794:LEBU_RS06300
uniprot id: C7NAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

523794:LEBU RS09965
gene id: 523794:LEBU_RS09965
uniprot id: C7NCM6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

523794:LEBU RS03010
gene id: 523794:LEBU_RS03010
uniprot id: C7N8M2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

523794:LEBU RS02400
gene id: 523794:LEBU_RS02400
uniprot id: C7NEM2
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

523794:LEBU RS11005
gene id: 523794:LEBU_RS11005
uniprot id: C7NDU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

523794:LEBU RS00625
gene id: 523794:LEBU_RS00625
uniprot id: C7NCY2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

523794:LEBU RS07720
gene id: 523794:LEBU_RS07720
uniprot id: C7NBA6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

523794:LEBU RS02525
gene id: 523794:LEBU_RS02525
uniprot id: C7NEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

523794:LEBU RS01085
gene id: 523794:LEBU_RS01085
uniprot id: C7NDH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

523794:LEBU RS00270
gene id: 523794:LEBU_RS00270
uniprot id: C7NCR9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

523794:LEBU RS00850
gene id: 523794:LEBU_RS00850
uniprot id: C7NDD3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

523794:LEBU RS08100
gene id: 523794:LEBU_RS08100
uniprot id: C7NBI3
names: Similarity
messages: Belongs to the tannase family.

523794:LEBU RS01230
gene id: 523794:LEBU_RS01230
uniprot id: C7NDK1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

523794:LEBU RS04870
gene id: 523794:LEBU_RS04870
uniprot id: C7N9P3
names: Similarity
messages: Belongs to the TrbG/VirB9 family.

523794:LEBU RS09220
gene id: 523794:LEBU_RS09220
uniprot id: C7NC45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

523794:LEBU RS10360
gene id: 523794:LEBU_RS10360
uniprot id: C7ND67
names: Similarity
messages: Belongs to the IMPACT family.

523794:LEBU RS02965
gene id: 523794:LEBU_RS02965
uniprot id: C7N8L3
names: Similarity
messages: Belongs to the LacAB/RpiB family.

523794:LEBU RS06305
gene id: 523794:LEBU_RS06305
uniprot id: C7NAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

523794:LEBU RS11290
gene id: 523794:LEBU_RS11290
uniprot id: C7NDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS10130
gene id: 523794:LEBU_RS10130
uniprot id: C7ND26
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

523794:LEBU RS07215
gene id: 523794:LEBU_RS07215
uniprot id: C7NB07
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

523794:LEBU RS06840
gene id: 523794:LEBU_RS06840
uniprot id: C7NAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS07070
gene id: 523794:LEBU_RS07070
uniprot id: C7NAY1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

523794:LEBU RS07700
gene id: 523794:LEBU_RS07700
uniprot id: C7NBA2
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

523794:LEBU RS07150
gene id: 523794:LEBU_RS07150
uniprot id: C7NAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

523794:LEBU RS08815
gene id: 523794:LEBU_RS08815
uniprot id: C7NBX2
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

523794:LEBU RS05390
gene id: 523794:LEBU_RS05390
uniprot id: C7NA03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

523794:LEBU RS06105
gene id: 523794:LEBU_RS06105
uniprot id: C7NAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

523794:LEBU RS09310
gene id: 523794:LEBU_RS09310
uniprot id: C7NC64
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

523794:LEBU RS01215
gene id: 523794:LEBU_RS01215
uniprot id: C7NDJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

523794:LEBU RS09155
gene id: 523794:LEBU_RS09155
uniprot id: C7NC38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

523794:LEBU RS08760
gene id: 523794:LEBU_RS08760
uniprot id: C7NBW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

523794:LEBU RS07685
gene id: 523794:LEBU_RS07685
uniprot id: C7NB99
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

523794:LEBU RS07620
gene id: 523794:LEBU_RS07620
uniprot id: C7NB86
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS06785
gene id: 523794:LEBU_RS06785
uniprot id: C7NAS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

523794:LEBU RS03025
gene id: 523794:LEBU_RS03025
uniprot id: C7N8M4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523794:LEBU RS04000
gene id: 523794:LEBU_RS04000
uniprot id: C7N971
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

523794:LEBU RS09270
gene id: 523794:LEBU_RS09270
uniprot id: C7NC55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS08050
gene id: 523794:LEBU_RS08050
uniprot id: C7NBH3
names: Similarity
messages: Belongs to the UPF0045 family.

523794:LEBU RS03810
gene id: 523794:LEBU_RS03810
uniprot id: C7N933
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

523794:LEBU RS07830
gene id: 523794:LEBU_RS07830
uniprot id: C7NBC9
names: Similarity
messages: Belongs to the GARS family.

523794:LEBU RS01615
gene id: 523794:LEBU_RS01615
uniprot id: C7NE40
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03980
gene id: 523794:LEBU_RS03980
uniprot id: C7N967
names: Similarity
messages: Belongs to the PspA/IM30 family.

523794:LEBU RS06965
gene id: 523794:LEBU_RS06965
uniprot id: C7NAW4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

523794:LEBU RS10005
gene id: 523794:LEBU_RS10005
uniprot id: C7NCN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

523794:LEBU RS04930
gene id: 523794:LEBU_RS04930
uniprot id: C7N9Q7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

523794:LEBU RS11415
gene id: 523794:LEBU_RS11415
uniprot id: C7NEE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

523794:LEBU RS08350
gene id: 523794:LEBU_RS08350
uniprot id: C7NBN2
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02060
gene id: 523794:LEBU_RS02060
uniprot id: C7NEC7
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

523794:LEBU RS00600
gene id: 523794:LEBU_RS00600
uniprot id: C7NCY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

523794:LEBU RS10465
gene id: 523794:LEBU_RS10465
uniprot id: C7ND80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

523794:LEBU RS07305
gene id: 523794:LEBU_RS07305
uniprot id: C7NB25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

523794:LEBU RS03990
gene id: 523794:LEBU_RS03990
uniprot id: C7N969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

523794:LEBU RS09380
gene id: 523794:LEBU_RS09380
uniprot id: C7NC78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523794:LEBU RS10490
gene id: 523794:LEBU_RS10490
uniprot id: C7ND85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

523794:LEBU RS03695
gene id: 523794:LEBU_RS03695
uniprot id: C7N910
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

523794:LEBU RS11215
gene id: 523794:LEBU_RS11215
uniprot id: C7NDX9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

523794:LEBU RS03710
gene id: 523794:LEBU_RS03710
uniprot id: C7N913
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

523794:LEBU RS03525
gene id: 523794:LEBU_RS03525
uniprot id: C7N8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

523794:LEBU RS08920
gene id: 523794:LEBU_RS08920
uniprot id: C7NBZ0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

523794:LEBU RS10265
gene id: 523794:LEBU_RS10265
uniprot id: C7ND49
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS02375
gene id: 523794:LEBU_RS02375
uniprot id: C7NEL7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

523794:LEBU RS07370
gene id: 523794:LEBU_RS07370
uniprot id: C7NB36
names: Similarity
messages: Belongs to the glycosyl hydrolase.

523794:LEBU RS05945
gene id: 523794:LEBU_RS05945
uniprot id: C7NAB1
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS07575
gene id: 523794:LEBU_RS07575
uniprot id: C7NB78
names: Similarity
messages: Belongs to the SAICAR synthetase family.

523794:LEBU RS10845
gene id: 523794:LEBU_RS10845
uniprot id: C7NDR5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523794:LEBU RS10570
gene id: 523794:LEBU_RS10570
uniprot id: C7NDA2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523794:LEBU RS08735
gene id: 523794:LEBU_RS08735
uniprot id: C7NBV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

523794:LEBU RS01200
gene id: 523794:LEBU_RS01200
uniprot id: C7NDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

523794:LEBU RS02860
gene id: 523794:LEBU_RS02860
uniprot id: C7N8J0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

523794:LEBU RS01825
gene id: 523794:LEBU_RS01825
uniprot id: C7NE82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

523794:LEBU RS09390
gene id: 523794:LEBU_RS09390
uniprot id: C7NC80
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

523794:LEBU RS06500
gene id: 523794:LEBU_RS06500
uniprot id: C7NAM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

523794:LEBU RS09450
gene id: 523794:LEBU_RS09450
uniprot id: C7NC91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

523794:LEBU RS01765
gene id: 523794:LEBU_RS01765
uniprot id: C7NE70
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

523794:LEBU RS11110
gene id: 523794:LEBU_RS11110
uniprot id: C7NDV9
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

523794:LEBU RS03825
gene id: 523794:LEBU_RS03825
uniprot id: C7N936
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

523794:LEBU RS04450
gene id: 523794:LEBU_RS04450
uniprot id: C7N9G1
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02990
gene id: 523794:LEBU_RS02990
uniprot id: C7N8L8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523794:LEBU RS06010
gene id: 523794:LEBU_RS06010
uniprot id: C7NAC4
names: Similarity
messages: Belongs to the ribF family.

523794:LEBU RS10810
gene id: 523794:LEBU_RS10810
uniprot id: C7NDQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

523794:LEBU RS00050
gene id: 523794:LEBU_RS00050
uniprot id: C7NCA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

523794:LEBU RS06025
gene id: 523794:LEBU_RS06025
uniprot id: C7NAC7
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

523794:LEBU RS01935
gene id: 523794:LEBU_RS01935
uniprot id: C7NEA3
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

523794:LEBU RS08800
gene id: 523794:LEBU_RS08800
uniprot id: C7NBW9
names: Similarity
messages: Belongs to the NAD synthetase family.

523794:LEBU RS02385
gene id: 523794:LEBU_RS02385
uniprot id: C7NEL9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

523794:LEBU RS05865
gene id: 523794:LEBU_RS05865
uniprot id: C7NA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

523794:LEBU RS05480
gene id: 523794:LEBU_RS05480
uniprot id: C7NA21
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

523794:LEBU RS10390
gene id: 523794:LEBU_RS10390
uniprot id: C7ND68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

523794:LEBU RS10305
gene id: 523794:LEBU_RS10305
uniprot id: C7ND56
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

523794:LEBU RS02210
gene id: 523794:LEBU_RS02210
uniprot id: C7NEJ0
names: Similarity
messages: Belongs to the DtxR/MntR family.

523794:LEBU RS11450
gene id: 523794:LEBU_RS11450
uniprot id: C7NEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS02220
gene id: 523794:LEBU_RS02220
uniprot id: C7NEJ2
names: Similarity
messages: Belongs to the peptidase S49 family.

523794:LEBU RS07970
gene id: 523794:LEBU_RS07970
uniprot id: C7NBF7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

523794:LEBU RS07665
gene id: 523794:LEBU_RS07665
uniprot id: C7NB95
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

523794:LEBU RS07280
gene id: 523794:LEBU_RS07280
uniprot id: C7NB20
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523794:LEBU RS02645
gene id: 523794:LEBU_RS02645
uniprot id: C7NES1
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01395
gene id: 523794:LEBU_RS01395
uniprot id: C7NDM8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

523794:LEBU RS10710
gene id: 523794:LEBU_RS10710
uniprot id: C7NDC2
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

523794:LEBU RS07590
gene id: 523794:LEBU_RS07590
uniprot id: C7NB81
names: Similarity
messages: Belongs to the ArsC family.

523794:LEBU RS10950
gene id: 523794:LEBU_RS10950
uniprot id: C7NDT6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS02675
gene id: 523794:LEBU_RS02675
uniprot id: C7NES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

523794:LEBU RS10170
gene id: 523794:LEBU_RS10170
uniprot id: C7ND35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

523794:LEBU RS02195
gene id: 523794:LEBU_RS02195
uniprot id: C7NEI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS01035
gene id: 523794:LEBU_RS01035
uniprot id: C7NDG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

523794:LEBU RS11510
gene id: 523794:LEBU_RS11510
uniprot id: C7NEG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS01205
gene id: 523794:LEBU_RS01205
uniprot id: C7NDJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

523794:LEBU RS05015
gene id: 523794:LEBU_RS05015
uniprot id: C7N9S5
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01665
gene id: 523794:LEBU_RS01665
uniprot id: C7NE49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523794:LEBU RS03455
gene id: 523794:LEBU_RS03455
uniprot id: C7N8W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS08295
gene id: 523794:LEBU_RS08295
uniprot id: C7NBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

523794:LEBU RS07190
gene id: 523794:LEBU_RS07190
uniprot id: C7NB02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.

523794:LEBU RS03175
gene id: 523794:LEBU_RS03175
uniprot id: C7N8Q4
names: Similarity
messages: Belongs to the bacterial secretin family.

523794:LEBU RS07460
gene id: 523794:LEBU_RS07460
uniprot id: C7NB54
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

523794:LEBU RS05775
gene id: 523794:LEBU_RS05775
uniprot id: C7NA79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

523794:LEBU RS09160
gene id: 523794:LEBU_RS09160
uniprot id: C7NC39
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

523794:LEBU RS10955
gene id: 523794:LEBU_RS10955
uniprot id: C7NDT7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

523794:LEBU RS02170
gene id: 523794:LEBU_RS02170
uniprot id: C7NEI2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

523794:LEBU RS05695
gene id: 523794:LEBU_RS05695
uniprot id: C7NA64
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

523794:LEBU RS10780
gene id: 523794:LEBU_RS10780
uniprot id: C7NDQ0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

523794:LEBU RS06280
gene id: 523794:LEBU_RS06280
uniprot id: C7NAH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

523794:LEBU RS03190
gene id: 523794:LEBU_RS03190
uniprot id: C7N8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

523794:LEBU RS07745
gene id: 523794:LEBU_RS07745
uniprot id: C7NBB1
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

523794:LEBU RS09580
gene id: 523794:LEBU_RS09580
uniprot id: C7NCF0
names: Similarity
messages: Belongs to the asp23 family.

523794:LEBU RS03255
gene id: 523794:LEBU_RS03255
uniprot id: C7N8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

523794:LEBU RS09820
gene id: 523794:LEBU_RS09820
uniprot id: C7NCJ8
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS04010
gene id: 523794:LEBU_RS04010
uniprot id: C7N973
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

523794:LEBU RS08390
gene id: 523794:LEBU_RS08390
uniprot id: C7NBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

523794:LEBU RS00145
gene id: 523794:LEBU_RS00145
uniprot id: C7NCC4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

523794:LEBU RS09560
gene id: 523794:LEBU_RS09560
uniprot id: C7NCE6
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

523794:LEBU RS07120
gene id: 523794:LEBU_RS07120
uniprot id: C7NAY9
names: Similarity
messages: Belongs to the citrate synthase family.

523794:LEBU RS08740
gene id: 523794:LEBU_RS08740
uniprot id: C7NBV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

523794:LEBU RS00685
gene id: 523794:LEBU_RS00685
uniprot id: C7NCZ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS06870
gene id: 523794:LEBU_RS06870
uniprot id: C7NAU5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

523794:LEBU RS06530
gene id: 523794:LEBU_RS06530
uniprot id: C7NAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

523794:LEBU RS04750
gene id: 523794:LEBU_RS04750
uniprot id: C7N9L8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

523794:LEBU RS07325
gene id: 523794:LEBU_RS07325
uniprot id: C7NB29
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

523794:LEBU RS01210
gene id: 523794:LEBU_RS01210
uniprot id: C7NDJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

523794:LEBU RS07540
gene id: 523794:LEBU_RS07540
uniprot id: C7NB69
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
messages: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is probably involved in transport of the alpha-glucosides trehalulose, turanose, maltulose and palatinose.

523794:LEBU RS03230
gene id: 523794:LEBU_RS03230
uniprot id: C7N8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

523794:LEBU RS02840
gene id: 523794:LEBU_RS02840
uniprot id: C7N8I7
names: Similarity
messages: Belongs to the CobT family.

523794:LEBU RS11430
gene id: 523794:LEBU_RS11430
uniprot id: C7NEE4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

523794:LEBU RS10670
gene id: 523794:LEBU_RS10670
uniprot id: C7NDB9
names: Similarity
messages: Belongs to the UPF0758 family.

523794:LEBU RS00645
gene id: 523794:LEBU_RS00645
uniprot id: C7NCY6
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

523794:LEBU RS01060
gene id: 523794:LEBU_RS01060
uniprot id: C7NDG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

523794:LEBU RS07380
gene id: 523794:LEBU_RS07380
uniprot id: C7NB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS02980
gene id: 523794:LEBU_RS02980
uniprot id: C7N8L6
names: Similarity
messages: Belongs to the aldolase LacD family.

523794:LEBU RS01940
gene id: 523794:LEBU_RS01940
uniprot id: C7NEA4
names: Similarity
messages: Belongs to the RecJ family.

523794:LEBU RS08440
gene id: 523794:LEBU_RS08440
uniprot id: C7NBP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS03400
gene id: 523794:LEBU_RS03400
uniprot id: C7N8V1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS10160
gene id: 523794:LEBU_RS10160
uniprot id: C7ND32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

523794:LEBU RS09550
gene id: 523794:LEBU_RS09550
uniprot id: C7NCE4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

523794:LEBU RS03215
gene id: 523794:LEBU_RS03215
uniprot id: C7N8R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

523794:LEBU RS11590
gene id: 523794:LEBU_RS11590
uniprot id: C7N9P2
names: Similarity
messages: Belongs to the TrbI/VirB10 family.

523794:LEBU RS09415
gene id: 523794:LEBU_RS09415
uniprot id: C7NC84
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

523794:LEBU RS00025
gene id: 523794:LEBU_RS00025
uniprot id: C7NC99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

523794:LEBU RS03440
gene id: 523794:LEBU_RS03440
uniprot id: C7N8V9
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

523794:LEBU RS01055
gene id: 523794:LEBU_RS01055
uniprot id: C7NDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

523794:LEBU RS06310
gene id: 523794:LEBU_RS06310
uniprot id: C7NAI4
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

523794:LEBU RS04760
gene id: 523794:LEBU_RS04760
uniprot id: C7N9M0
names: Similarity
messages: Belongs to the peptidase C40 family.

523794:LEBU RS09725
gene id: 523794:LEBU_RS09725
uniprot id: C7NCH9
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

523794:LEBU RS06365
gene id: 523794:LEBU_RS06365
uniprot id: C7NAJ5
names: Similarity
messages: Belongs to the nitroreductase family.

523794:LEBU RS01800
gene id: 523794:LEBU_RS01800
uniprot id: C7NE77
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01235
gene id: 523794:LEBU_RS01235
uniprot id: C7NDK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

523794:LEBU RS06060
gene id: 523794:LEBU_RS06060
uniprot id: C7NAD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

523794:LEBU RS05880
gene id: 523794:LEBU_RS05880
uniprot id: C7NA99
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS05060
gene id: 523794:LEBU_RS05060
uniprot id: C7N9T4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

523794:LEBU RS03310
gene id: 523794:LEBU_RS03310
uniprot id: C7N8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

523794:LEBU RS09345
gene id: 523794:LEBU_RS09345
uniprot id: C7NC71
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

523794:LEBU RS06810
gene id: 523794:LEBU_RS06810
uniprot id: C7NAT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

523794:LEBU RS01430
gene id: 523794:LEBU_RS01430
uniprot id: C7NDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

523794:LEBU RS06215
gene id: 523794:LEBU_RS06215
uniprot id: C7NAG4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

523794:LEBU RS01920
gene id: 523794:LEBU_RS01920
uniprot id: C7NEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

523794:LEBU RS01635
gene id: 523794:LEBU_RS01635
uniprot id: C7NE44
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
messages: In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS03270
gene id: 523794:LEBU_RS03270
uniprot id: C7N8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

523794:LEBU RS06490
gene id: 523794:LEBU_RS06490
uniprot id: C7NAL9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

523794:LEBU RS03060
gene id: 523794:LEBU_RS03060
uniprot id: C7N8N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

523794:LEBU RS07505
gene id: 523794:LEBU_RS07505
uniprot id: C7NB62
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

523794:LEBU RS09685
gene id: 523794:LEBU_RS09685
uniprot id: C7NCH1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

523794:LEBU RS00140
gene id: 523794:LEBU_RS00140
uniprot id: C7NCC3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

523794:LEBU RS06865
gene id: 523794:LEBU_RS06865
uniprot id: C7NAU4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

523794:LEBU RS02995
gene id: 523794:LEBU_RS02995
uniprot id: C7N8L9
names: Activity Regulation
names: Induction
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.
messages: Induced during growth on lactose or lactulose.
messages: Inhibited by both galactose-6-phosphate and ATP.

523794:LEBU RS08960
gene id: 523794:LEBU_RS08960
uniprot id: C7NBZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

523794:LEBU RS03365
gene id: 523794:LEBU_RS03365
uniprot id: C7N8U4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

523794:LEBU RS06245
gene id: 523794:LEBU_RS06245
uniprot id: C7NAH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

523794:LEBU RS06515
gene id: 523794:LEBU_RS06515
uniprot id: C7NAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

523794:LEBU RS03640
gene id: 523794:LEBU_RS03640
uniprot id: C7N8Z9
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

523794:LEBU RS11230
gene id: 523794:LEBU_RS11230
uniprot id: C7NDY2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

523794:LEBU RS08790
gene id: 523794:LEBU_RS08790
uniprot id: C7NBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

523794:LEBU RS05770
gene id: 523794:LEBU_RS05770
uniprot id: C7NA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS11175
gene id: 523794:LEBU_RS11175
uniprot id: C7NDX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS10790
gene id: 523794:LEBU_RS10790
uniprot id: C7NDQ2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

523794:LEBU RS08645
gene id: 523794:LEBU_RS08645
uniprot id: C7NBT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

523794:LEBU RS06285
gene id: 523794:LEBU_RS06285
uniprot id: C7NAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

523794:LEBU RS01655
gene id: 523794:LEBU_RS01655
uniprot id: C7NE47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

523794:LEBU RS00855
gene id: 523794:LEBU_RS00855
uniprot id: C7NDD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

523794:LEBU RS02875
gene id: 523794:LEBU_RS02875
uniprot id: C7N8J5
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

523794:LEBU RS07395
gene id: 523794:LEBU_RS07395
uniprot id: C7NB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

523794:LEBU RS09590
gene id: 523794:LEBU_RS09590
uniprot id: C7NCF2
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

523794:LEBU RS01295
gene id: 523794:LEBU_RS01295
uniprot id: C7NDL4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

523794:LEBU RS03865
gene id: 523794:LEBU_RS03865
uniprot id: C7N944
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

523794:LEBU RS02165
gene id: 523794:LEBU_RS02165
uniprot id: C7NEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

523794:LEBU RS03645
gene id: 523794:LEBU_RS03645
uniprot id: C7N900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

523794:LEBU RS03280
gene id: 523794:LEBU_RS03280
uniprot id: C7N8S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523794:LEBU RS09105
gene id: 523794:LEBU_RS09105
uniprot id: C7NC28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

523794:LEBU RS03425
gene id: 523794:LEBU_RS03425
uniprot id: C7N8V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

523794:LEBU RS05875
gene id: 523794:LEBU_RS05875
uniprot id: C7NA98
names: Similarity
messages: Belongs to the UDPGP type 2 family.

523794:LEBU RS08890
gene id: 523794:LEBU_RS08890
uniprot id: C7NBY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

523794:LEBU RS05445
gene id: 523794:LEBU_RS05445
uniprot id: C7NA12
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

523794:LEBU RS07815
gene id: 523794:LEBU_RS07815
uniprot id: C7NBC6
names: Similarity
messages: Belongs to the peptidase S66 family.

523794:LEBU RS02450
gene id: 523794:LEBU_RS02450
uniprot id: C7NEN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS05915
gene id: 523794:LEBU_RS05915
uniprot id: C7NAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

523794:LEBU RS10420
gene id: 523794:LEBU_RS10420
uniprot id: C7ND74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

523794:LEBU RS05540
gene id: 523794:LEBU_RS05540
uniprot id: C7NA33
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

523794:LEBU RS10975
gene id: 523794:LEBU_RS10975
uniprot id: C7NDU1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

523794:LEBU RS05735
gene id: 523794:LEBU_RS05735
uniprot id: C7NA71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS05590
gene id: 523794:LEBU_RS05590
uniprot id: C7NA44
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

523794:LEBU RS08850
gene id: 523794:LEBU_RS08850
uniprot id: C7NBX9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

523794:LEBU RS11410
gene id: 523794:LEBU_RS11410
uniprot id: C7NEE0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS00705
gene id: 523794:LEBU_RS00705
uniprot id: C7NCZ8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

523794:LEBU RS08875
gene id: 523794:LEBU_RS08875
uniprot id: C7NBY4
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas13a family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements (spacer sequences) and target invading nucleic acids. Unlike many single-component effectors, this CRISPR-Cas system targets RNA (PubMed:27669025). CRISPR clusters are transcribed from pre-CRISPR RNA (crRNA) and processed into crRNA by this protein (PubMed:27669025, PubMed:28475872, PubMed:28757251). pre-crRNA processing yields a 5'-OH and probably a 2',3'-cyclic phosphate (PubMed:27669025). Also cleaves pre-crRNA from several other type VI-A CRISPR systems (PubMed:28475872). Cleaves linear target ssRNA in a crRNA-dependent fashion, preferentially before U residues (PubMed:27669025, PubMed:28475872). Cleavage of target ssRNA is about 80-fold faster than pre-crRNA processing and uses a different active site (PubMed:27669025). Binding a viable target RNA target activates this protein for non-specific RNA degradation in vitro (called collateral RNA degradation) (PubMed:27669025, PubMed:28475872, PubMed:28757251). Activation occurs with 10 fM target RNA (PubMed:28475872). crRNA maturation is not essential for activation of RNA degradation, but lack of mature crRNA (due to mutagenesis) decreases activation levels (PubMed:28475872). This system has a 3' protospacer flanking site in the target RNA (PFS), which is C and unavailable to base pair with crRNA (PFS is equivalent to PAM, the protospacer adjacent motif) (PubMed:28757251).
messages: Can be used to detect low levels of cellular transcripts, which might be useful to create sequence-specific RNA-targeting tools (PubMed:27669025).
messages: Crystals show the 3'-end of target RNA interacting with an adjacent protein molecule, and mutagenesis of those amino acid residues decreases target RNA cleavage, but it is not clear if this is physiological (PubMed:28757251).
messages: Part of a type VI-A uridine-prefering CRISPR-Cas system.
messages: Pre-crRNA processing is metal independent, while crRNA-guided target RNA cleavage is dependent on divalent metal (i.e. inhibited by EDTA) (PubMed:27669025).
messages: Target RNA acts as an activator for non-specific ssRNA cleavage; the target RNA and complementary crRNA must both be at least 20 nucleotides long to activate the HEPN-like catalytic pocket for RNase activity (PubMed:28757251).
messages: The X-ray structure in complex with crRNA and target RNA shows a crRNA-recognition lobe (REC, residues 1-360) which anchors the crRNA repeat and a nuclease lobe (NUC, residues 361-1159) which binds the spacer crRNA-target RNA duplex and cleaves target RNA (PubMed:28757251). The target ssRNase active sites are within the 2 HEPN-like folds, which interact in vivo to form the functional active site (PubMed:26593719, PubMed:28757251). The N-terminal region and HEPN-like fold 2 play a role in pre-crRNA processing (PubMed:28475872). Binding of target RNA to the Cas13a-crRNA complex induces conformational changes that include bringing the 2 HEPN-like domains together to form the target cleavage active site, widening the channel that binds the crRNA-target RNA duplex, facilitating contact between the NUC lobe and the RNA duplex, and altering the conformation of the crRNA (PubMed:28757251).

523794:LEBU RS09750
gene id: 523794:LEBU_RS09750
uniprot id: C7NCI4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

523794:LEBU RS10895
gene id: 523794:LEBU_RS10895
uniprot id: C7NDS5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

523794:LEBU RS02155
gene id: 523794:LEBU_RS02155
uniprot id: C7NEH9
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01225
gene id: 523794:LEBU_RS01225
uniprot id: C7NDK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

523794:LEBU RS10980
gene id: 523794:LEBU_RS10980
uniprot id: C7NDU2
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

523794:LEBU RS01045
gene id: 523794:LEBU_RS01045
uniprot id: C7NDG2
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS10205
gene id: 523794:LEBU_RS10205
uniprot id: C7ND42
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

523794:LEBU RS07430
gene id: 523794:LEBU_RS07430
uniprot id: C7NB48
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

523794:LEBU RS01265
gene id: 523794:LEBU_RS01265
uniprot id: C7NDK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

523794:LEBU RS04255
gene id: 523794:LEBU_RS04255
uniprot id: C7N9C2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

523794:LEBU RS02630
gene id: 523794:LEBU_RS02630
uniprot id: C7NER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

523794:LEBU RS01305
gene id: 523794:LEBU_RS01305
uniprot id: C7NDL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

523794:LEBU RS09605
gene id: 523794:LEBU_RS09605
uniprot id: C7NCF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

523794:LEBU RS08385
gene id: 523794:LEBU_RS08385
uniprot id: C7NBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

523794:LEBU RS07440
gene id: 523794:LEBU_RS07440
uniprot id: C7NB50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

523794:LEBU RS09950
gene id: 523794:LEBU_RS09950
uniprot id: C7NCM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

523794:LEBU RS09225
gene id: 523794:LEBU_RS09225
uniprot id: C7NC46
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

523794:LEBU RS07105
gene id: 523794:LEBU_RS07105
uniprot id: C7NAY7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523794:LEBU RS00080
gene id: 523794:LEBU_RS00080
uniprot id: C7NCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

523794:LEBU RS01040
gene id: 523794:LEBU_RS01040
uniprot id: C7NDG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

523794:LEBU RS10770
gene id: 523794:LEBU_RS10770
uniprot id: C7NDP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

523794:LEBU RS04245
gene id: 523794:LEBU_RS04245
uniprot id: C7N9C0
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

523794:LEBU RS08860
gene id: 523794:LEBU_RS08860
uniprot id: C7NBY1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

523794:LEBU RS01955
gene id: 523794:LEBU_RS01955
uniprot id: C7NEA7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

523794:LEBU RS01740
gene id: 523794:LEBU_RS01740
uniprot id: C7NE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

523794:LEBU RS07740
gene id: 523794:LEBU_RS07740
uniprot id: C7NBB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

523794:LEBU RS01590
gene id: 523794:LEBU_RS01590
uniprot id: C7NE35
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

523794:LEBU RS07435
gene id: 523794:LEBU_RS07435
uniprot id: C7NB49
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

523794:LEBU RS10875
gene id: 523794:LEBU_RS10875
uniprot id: C7NDS1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523794:LEBU RS09575
gene id: 523794:LEBU_RS09575
uniprot id: C7NCE9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

523794:LEBU RS09960
gene id: 523794:LEBU_RS09960
uniprot id: C7NCM5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

523794:LEBU RS02320
gene id: 523794:LEBU_RS02320
uniprot id: C7NEK7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

523794:LEBU RS06460
gene id: 523794:LEBU_RS06460
uniprot id: C7NAL4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

523794:LEBU RS10565
gene id: 523794:LEBU_RS10565
uniprot id: C7NDA1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

523794:LEBU RS07310
gene id: 523794:LEBU_RS07310
uniprot id: C7NB26
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS05065
gene id: 523794:LEBU_RS05065
uniprot id: C7N9T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

523794:LEBU RS08490
gene id: 523794:LEBU_RS08490
uniprot id: C7NBQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS11205
gene id: 523794:LEBU_RS11205
uniprot id: C7NDX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

523794:LEBU RS00465
gene id: 523794:LEBU_RS00465
uniprot id: C7NCV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

523794:LEBU RS01840
gene id: 523794:LEBU_RS01840
uniprot id: C7NE85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

523794:LEBU RS03135
gene id: 523794:LEBU_RS03135
uniprot id: C7N8P6
names: Similarity
messages: Belongs to the fabD family.

523794:LEBU RS07465
gene id: 523794:LEBU_RS07465
uniprot id: C7NB55
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

523794:LEBU RS00280
gene id: 523794:LEBU_RS00280
uniprot id: C7NCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS03435
gene id: 523794:LEBU_RS03435
uniprot id: C7N8V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS00815
gene id: 523794:LEBU_RS00815
uniprot id: C7ND19
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

523794:LEBU RS03715
gene id: 523794:LEBU_RS03715
uniprot id: C7N914
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

523794:LEBU RS11535
gene id: 523794:LEBU_RS11535
uniprot id: C7NEG5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

523794:LEBU RS11260
gene id: 523794:LEBU_RS11260
uniprot id: C7NDY8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

523794:LEBU RS03805
gene id: 523794:LEBU_RS03805
uniprot id: C7N932
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523794:LEBU RS10085
gene id: 523794:LEBU_RS10085
uniprot id: C7NCP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

523794:LEBU RS05785
gene id: 523794:LEBU_RS05785
uniprot id: C7NA81
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

523794:LEBU RS03485
gene id: 523794:LEBU_RS03485
uniprot id: C7N8W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

523794:LEBU RS07850
gene id: 523794:LEBU_RS07850
uniprot id: C7NBD3
names: Similarity
messages: Belongs to the YoeB family.

523794:LEBU RS10405
gene id: 523794:LEBU_RS10405
uniprot id: C7ND71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

523794:LEBU RS01220
gene id: 523794:LEBU_RS01220
uniprot id: C7NDJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

523794:LEBU RS07650
gene id: 523794:LEBU_RS07650
uniprot id: C7NB92
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02425
gene id: 523794:LEBU_RS02425
uniprot id: C7NEM7
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS06185
gene id: 523794:LEBU_RS06185
uniprot id: C7NAF7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

523794:LEBU RS09920
gene id: 523794:LEBU_RS09920
uniprot id: C7NCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

523794:LEBU RS07040
gene id: 523794:LEBU_RS07040
uniprot id: C7NAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

523794:LEBU RS06830
gene id: 523794:LEBU_RS06830
uniprot id: C7NAT7
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03925
gene id: 523794:LEBU_RS03925
uniprot id: C7N956
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

523794:LEBU RS10165
gene id: 523794:LEBU_RS10165
uniprot id: C7ND34
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

523794:LEBU RS10180
gene id: 523794:LEBU_RS10180
uniprot id: C7ND37
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

523794:LEBU RS03800
gene id: 523794:LEBU_RS03800
uniprot id: C7N931
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS09015
gene id: 523794:LEBU_RS09015
uniprot id: C7NC09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

523794:LEBU RS00420
gene id: 523794:LEBU_RS00420
uniprot id: C7NCU6
names: Similarity
messages: Belongs to the YoeB family.

523794:LEBU RS06035
gene id: 523794:LEBU_RS06035
uniprot id: C7NAC9
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

523794:LEBU RS09990
gene id: 523794:LEBU_RS09990
uniprot id: C7NCN1
names: Similarity
messages: Belongs to the GSP E family.

523794:LEBU RS08510
gene id: 523794:LEBU_RS08510
uniprot id: C7NBR2
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

523794:LEBU RS04320
gene id: 523794:LEBU_RS04320
uniprot id: C7N9D5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

523794:LEBU RS00595
gene id: 523794:LEBU_RS00595
uniprot id: C7NCY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

523794:LEBU RS04850
gene id: 523794:LEBU_RS04850
uniprot id: C7N9N9
names: Similarity
messages: Belongs to the GSP E family.

523794:LEBU RS03510
gene id: 523794:LEBU_RS03510
uniprot id: C7N8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

523794:LEBU RS01075
gene id: 523794:LEBU_RS01075
uniprot id: C7NDG8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

523794:LEBU RS04335
gene id: 523794:LEBU_RS04335
uniprot id: C7N9D8
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS08970
gene id: 523794:LEBU_RS08970
uniprot id: C7NC00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

523794:LEBU RS03540
gene id: 523794:LEBU_RS03540
uniprot id: C7N8X9
names: Similarity
messages: Belongs to the peptidase C40 family.

523794:LEBU RS04985
gene id: 523794:LEBU_RS04985
uniprot id: C7N9R9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

523794:LEBU RS09945
gene id: 523794:LEBU_RS09945
uniprot id: C7NCM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

523794:LEBU RS05720
gene id: 523794:LEBU_RS05720
uniprot id: C7NA68
names: Similarity
messages: Belongs to the LacAB/RpiB family.

523794:LEBU RS02500
gene id: 523794:LEBU_RS02500
uniprot id: C7NEP2
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

523794:LEBU RS02800
gene id: 523794:LEBU_RS02800
uniprot id: C7N8I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

523794:LEBU RS10325
gene id: 523794:LEBU_RS10325
uniprot id: C7ND60
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS10885
gene id: 523794:LEBU_RS10885
uniprot id: C7NDS3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

523794:LEBU RS08375
gene id: 523794:LEBU_RS08375
uniprot id: C7NBN7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

523794:LEBU RS05510
gene id: 523794:LEBU_RS05510
uniprot id: C7NA27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

523794:LEBU RS00320
gene id: 523794:LEBU_RS00320
uniprot id: C7NCS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

523794:LEBU RS11525
gene id: 523794:LEBU_RS11525
uniprot id: C7NEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

523794:LEBU RS05725
gene id: 523794:LEBU_RS05725
uniprot id: C7NA69
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

523794:LEBU RS04270
gene id: 523794:LEBU_RS04270
uniprot id: C7N9C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

523794:LEBU RS10495
gene id: 523794:LEBU_RS10495
uniprot id: C7ND86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

523794:LEBU RS05740
gene id: 523794:LEBU_RS05740
uniprot id: C7NA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS08710
gene id: 523794:LEBU_RS08710
uniprot id: C7NBV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

523794:LEBU RS10660
gene id: 523794:LEBU_RS10660
uniprot id: C7NDB7
names: Similarity
messages: Belongs to the peptidase M18 family.

523794:LEBU RS08990
gene id: 523794:LEBU_RS08990
uniprot id: C7NC04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

523794:LEBU RS06165
gene id: 523794:LEBU_RS06165
uniprot id: C7NAF3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

523794:LEBU RS04300
gene id: 523794:LEBU_RS04300
uniprot id: C7N9D1
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

523794:LEBU RS03375
gene id: 523794:LEBU_RS03375
uniprot id: C7N8U6
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

523794:LEBU RS01110
gene id: 523794:LEBU_RS01110
uniprot id: C7NDH5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

523794:LEBU RS04875
gene id: 523794:LEBU_RS04875
uniprot id: C7N9P4
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS01790
gene id: 523794:LEBU_RS01790
uniprot id: C7NE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS09370
gene id: 523794:LEBU_RS09370
uniprot id: C7NC76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

523794:LEBU RS03095
gene id: 523794:LEBU_RS03095
uniprot id: C7N8N8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

523794:LEBU RS07680
gene id: 523794:LEBU_RS07680
uniprot id: C7NB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

523794:LEBU RS08200
gene id: 523794:LEBU_RS08200
uniprot id: C7NBK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

523794:LEBU RS02900
gene id: 523794:LEBU_RS02900
uniprot id: C7N8K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

523794:LEBU RS04405
gene id: 523794:LEBU_RS04405
uniprot id: C7N9F2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

523794:LEBU RS01080
gene id: 523794:LEBU_RS01080
uniprot id: C7NDG9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS08405
gene id: 523794:LEBU_RS08405
uniprot id: C7NBP2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS04130
gene id: 523794:LEBU_RS04130
uniprot id: C7N997
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

523794:LEBU RS00720
gene id: 523794:LEBU_RS00720
uniprot id: C7ND01
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

523794:LEBU RS06415
gene id: 523794:LEBU_RS06415
uniprot id: C7NAK5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

523794:LEBU RS08625
gene id: 523794:LEBU_RS08625
uniprot id: C7NBT5
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS10230
gene id: 523794:LEBU_RS10230
uniprot id: C7ND47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

523794:LEBU RS05365
gene id: 523794:LEBU_RS05365
uniprot id: C7N9Z6
names: Similarity
messages: Belongs to the UPF0246 family.

523794:LEBU RS08965
gene id: 523794:LEBU_RS08965
uniprot id: C7NBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

523794:LEBU RS02805
gene id: 523794:LEBU_RS02805
uniprot id: C7N8I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS09735
gene id: 523794:LEBU_RS09735
uniprot id: C7NCI1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

523794:LEBU RS04345
gene id: 523794:LEBU_RS04345
uniprot id: C7N9E0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

523794:LEBU RS01250
gene id: 523794:LEBU_RS01250
uniprot id: C7NDK5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

523794:LEBU RS09860
gene id: 523794:LEBU_RS09860
uniprot id: C7NCK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523794:LEBU RS12360
gene id: 523794:LEBU_RS12360
uniprot id: C7N9B5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523794:LEBU RS01030
gene id: 523794:LEBU_RS01030
uniprot id: C7NDF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

523794:LEBU RS00265
gene id: 523794:LEBU_RS00265
uniprot id: C7NCR8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

523794:LEBU RS00660
gene id: 523794:LEBU_RS00660
uniprot id: C7NCY9
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

523794:LEBU RS11190
gene id: 523794:LEBU_RS11190
uniprot id: C7NDX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

523794:LEBU RS08745
gene id: 523794:LEBU_RS08745
uniprot id: C7NBV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

523794:LEBU RS05170
gene id: 523794:LEBU_RS05170
uniprot id: C7N9V6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

523794:LEBU RS09275
gene id: 523794:LEBU_RS09275
uniprot id: C7NC57
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

523794:LEBU RS06420
gene id: 523794:LEBU_RS06420
uniprot id: C7NAK6
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

523794:LEBU RS03115
gene id: 523794:LEBU_RS03115
uniprot id: C7N8P2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

523794:LEBU RS06425
gene id: 523794:LEBU_RS06425
uniprot id: C7NAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

523794:LEBU RS11475
gene id: 523794:LEBU_RS11475
uniprot id: C7NEF3
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03780
gene id: 523794:LEBU_RS03780
uniprot id: C7N927
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

523794:LEBU RS03770
gene id: 523794:LEBU_RS03770
uniprot id: C7N925
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

523794:LEBU RS09885
gene id: 523794:LEBU_RS09885
uniprot id: C7NCL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS00940
gene id: 523794:LEBU_RS00940
uniprot id: C7NDE8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

523794:LEBU RS00470
gene id: 523794:LEBU_RS00470
uniprot id: C7NCV6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

523794:LEBU RS09385
gene id: 523794:LEBU_RS09385
uniprot id: C7NC79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

523794:LEBU RS03495
gene id: 523794:LEBU_RS03495
uniprot id: C7N8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

523794:LEBU RS08060
gene id: 523794:LEBU_RS08060
uniprot id: C7NBH5
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

523794:LEBU RS02985
gene id: 523794:LEBU_RS02985
uniprot id: C7N8L7
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

523794:LEBU RS06335
gene id: 523794:LEBU_RS06335
uniprot id: C7NAI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523794:LEBU RS05710
gene id: 523794:LEBU_RS05710
uniprot id: C7NA66
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

523794:LEBU RS05380
gene id: 523794:LEBU_RS05380
uniprot id: C7NA01
names: Similarity
messages: Belongs to the UPF0236 family.

523794:LEBU RS05610
gene id: 523794:LEBU_RS05610
uniprot id: C7NA47
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

523794:LEBU RS01190
gene id: 523794:LEBU_RS01190
uniprot id: C7NDJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

523794:LEBU RS02275
gene id: 523794:LEBU_RS02275
uniprot id: C7NEK3
names: Similarity
messages: Belongs to the CapA family.

523794:LEBU RS05225
gene id: 523794:LEBU_RS05225
uniprot id: C7N9W7
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS05840
gene id: 523794:LEBU_RS05840
uniprot id: C7NA91
names: Similarity
messages: Belongs to the YoeB family.

523794:LEBU RS01775
gene id: 523794:LEBU_RS01775
uniprot id: C7NE72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS10400
gene id: 523794:LEBU_RS10400
uniprot id: C7ND70
names: Similarity
messages: Belongs to the phosphohexose mutase family.

523794:LEBU RS01310
gene id: 523794:LEBU_RS01310
uniprot id: C7NDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

523794:LEBU RS09150
gene id: 523794:LEBU_RS09150
uniprot id: C7NC37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

523794:LEBU RS09025
gene id: 523794:LEBU_RS09025
uniprot id: C7NC11
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

523794:LEBU RS08210
gene id: 523794:LEBU_RS08210
uniprot id: C7NBK4
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

523794:LEBU RS04110
gene id: 523794:LEBU_RS04110
uniprot id: C7N993
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

523794:LEBU RS04060
gene id: 523794:LEBU_RS04060
uniprot id: C7N983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

523794:LEBU RS06220
gene id: 523794:LEBU_RS06220
uniprot id: C7NAG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

523794:LEBU RS02475
gene id: 523794:LEBU_RS02475
uniprot id: C7NEN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS00565
gene id: 523794:LEBU_RS00565
uniprot id: C7NCX4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

523794:LEBU RS08185
gene id: 523794:LEBU_RS08185
uniprot id: C7NBJ9
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

523794:LEBU RS09355
gene id: 523794:LEBU_RS09355
uniprot id: C7NC73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

523794:LEBU RS04115
gene id: 523794:LEBU_RS04115
uniprot id: C7N994
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

523794:LEBU RS11195
gene id: 523794:LEBU_RS11195
uniprot id: C7NDX6
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS02935
gene id: 523794:LEBU_RS02935
uniprot id: C7N8K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS10965
gene id: 523794:LEBU_RS10965
uniprot id: C7NDT9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS08400
gene id: 523794:LEBU_RS08400
uniprot id: C7NBP1
names: Similarity
messages: Belongs to the thymidylate kinase family.

523794:LEBU RS02190
gene id: 523794:LEBU_RS02190
uniprot id: C7NEI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS05680
gene id: 523794:LEBU_RS05680
uniprot id: C7NA61
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

523794:LEBU RS08265
gene id: 523794:LEBU_RS08265
uniprot id: C7NBL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS00395
gene id: 523794:LEBU_RS00395
uniprot id: C7NCU3
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

523794:LEBU RS03325
gene id: 523794:LEBU_RS03325
uniprot id: C7N8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

523794:LEBU RS00700
gene id: 523794:LEBU_RS00700
uniprot id: C7NCZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

523794:LEBU RS09210
gene id: 523794:LEBU_RS09210
uniprot id: C7NC43
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

523794:LEBU RS00865
gene id: 523794:LEBU_RS00865
uniprot id: C7NDD6
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

523794:LEBU RS06510
gene id: 523794:LEBU_RS06510
uniprot id: C7NAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

523794:LEBU RS02620
gene id: 523794:LEBU_RS02620
uniprot id: C7NER6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

523794:LEBU RS11280
gene id: 523794:LEBU_RS11280
uniprot id: C7NDZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

523794:LEBU RS02605
gene id: 523794:LEBU_RS02605
uniprot id: C7NER3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

523794:LEBU RS03855
gene id: 523794:LEBU_RS03855
uniprot id: C7N942
names: Similarity
messages: Belongs to the DNase I family.

523794:LEBU RS09360
gene id: 523794:LEBU_RS09360
uniprot id: C7NC74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

523794:LEBU RS08220
gene id: 523794:LEBU_RS08220
uniprot id: C7NBK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

523794:LEBU RS04285
gene id: 523794:LEBU_RS04285
uniprot id: C7N9C8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

523794:LEBU RS06860
gene id: 523794:LEBU_RS06860
uniprot id: C7NAU3
names: Similarity
messages: Belongs to the NAPRTase family.

523794:LEBU RS10645
gene id: 523794:LEBU_RS10645
uniprot id: C7NDB4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS11000
gene id: 523794:LEBU_RS11000
uniprot id: C7NDU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

523794:LEBU RS01260
gene id: 523794:LEBU_RS01260
uniprot id: C7NDK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

523794:LEBU RS03830
gene id: 523794:LEBU_RS03830
uniprot id: C7N937
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

523794:LEBU RS03795
gene id: 523794:LEBU_RS03795
uniprot id: C7N930
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

523794:LEBU RS10410
gene id: 523794:LEBU_RS10410
uniprot id: C7ND72
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

523794:LEBU RS02670
gene id: 523794:LEBU_RS02670
uniprot id: C7NES6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

523794:LEBU RS08325
gene id: 523794:LEBU_RS08325
uniprot id: C7NBM7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

523794:LEBU RS09330
gene id: 523794:LEBU_RS09330
uniprot id: C7NC68
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

523794:LEBU RS11140
gene id: 523794:LEBU_RS11140
uniprot id: C7NDW5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

523794:LEBU RS01240
gene id: 523794:LEBU_RS01240
uniprot id: C7NDK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

523794:LEBU RS03080
gene id: 523794:LEBU_RS03080
uniprot id: C7N8N5
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS00845
gene id: 523794:LEBU_RS00845
uniprot id: C7NDD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

523794:LEBU RS09255
gene id: 523794:LEBU_RS09255
uniprot id: C7NC52
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

523794:LEBU RS10395
gene id: 523794:LEBU_RS10395
uniprot id: C7ND69
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS07570
gene id: 523794:LEBU_RS07570
uniprot id: C7NB77
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS07660
gene id: 523794:LEBU_RS07660
uniprot id: C7NB94
names: Subcellular Location Annotation
messages: Membrane

523794:LEBU RS03505
gene id: 523794:LEBU_RS03505
uniprot id: C7N8X2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

523794:LEBU RS00735
gene id: 523794:LEBU_RS00735
uniprot id: C7ND04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

523794:LEBU RS07175
gene id: 523794:LEBU_RS07175
uniprot id: C7NB00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

523794:LEBU RS10655
gene id: 523794:LEBU_RS10655
uniprot id: C7NDB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

523794:LEBU RS02755
gene id: 523794:LEBU_RS02755
uniprot id: C7N8H3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

523794:LEBU RS09795
gene id: 523794:LEBU_RS09795
uniprot id: C7NCJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

523794:LEBU RS09010
gene id: 523794:LEBU_RS09010
uniprot id: C7NC08
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

523794:LEBU RS03300
gene id: 523794:LEBU_RS03300
uniprot id: C7N8S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

523794:LEBU RS00400
gene id: 523794:LEBU_RS00400
uniprot id: C7NCU4
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

523794:LEBU RS08955
gene id: 523794:LEBU_RS08955
uniprot id: C7NBZ7
names: Similarity
messages: Belongs to the EfeM/EfeO family.

523794:LEBU RS05780
gene id: 523794:LEBU_RS05780
uniprot id: C7NA80
names: Similarity
messages: Belongs to the peptidase M13 family.

523794:LEBU RS09985
gene id: 523794:LEBU_RS09985
uniprot id: C7NCN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

523794:LEBU RS07415
gene id: 523794:LEBU_RS07415
uniprot id: C7NB45
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.