521097:COCH RS00415
gene id: 521097:COCH_RS00415
uniprot id: C7M4L4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

521097:COCH RS04185
gene id: 521097:COCH_RS04185
uniprot id: C7M940
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

521097:COCH RS07500
gene id: 521097:COCH_RS07500
uniprot id: C7M6R5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

521097:COCH RS09250
gene id: 521097:COCH_RS09250
uniprot id: C7M8K5
names: Similarity
messages: Belongs to the BshC family.

521097:COCH RS00075
gene id: 521097:COCH_RS00075
uniprot id: C7M448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521097:COCH RS06090
gene id: 521097:COCH_RS06090
uniprot id: C7M4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

521097:COCH RS09340
gene id: 521097:COCH_RS09340
uniprot id: C7M8M3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

521097:COCH RS09160
gene id: 521097:COCH_RS09160
uniprot id: C7M8I7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

521097:COCH RS06570
gene id: 521097:COCH_RS06570
uniprot id: C7M5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

521097:COCH RS06005
gene id: 521097:COCH_RS06005
uniprot id: C7M4V9
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS11070
gene id: 521097:COCH_RS11070
uniprot id: C7M4F7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09920
gene id: 521097:COCH_RS09920
uniprot id: C7M8X8
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

521097:COCH RS08890
gene id: 521097:COCH_RS08890
uniprot id: C7M853
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

521097:COCH RS00750
gene id: 521097:COCH_RS00750
uniprot id: C7M515
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS06245
gene id: 521097:COCH_RS06245
uniprot id: C7M588
names: Cofactor
messages: Binds 1 zinc ion per subunit.

521097:COCH RS08785
gene id: 521097:COCH_RS08785
uniprot id: C7M832
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

521097:COCH RS01610
gene id: 521097:COCH_RS01610
uniprot id: C7M605
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS06020
gene id: 521097:COCH_RS06020
uniprot id: C7M4W2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

521097:COCH RS00995
gene id: 521097:COCH_RS00995
uniprot id: C7M559
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

521097:COCH RS10830
gene id: 521097:COCH_RS10830
uniprot id: C7M3R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

521097:COCH RS06675
gene id: 521097:COCH_RS06675
uniprot id: C7M5R8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

521097:COCH RS10330
gene id: 521097:COCH_RS10330
uniprot id: C7M9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

521097:COCH RS01505
gene id: 521097:COCH_RS01505
uniprot id: C7M5Q0
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

521097:COCH RS03610
gene id: 521097:COCH_RS03610
uniprot id: C7M8A2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521097:COCH RS04980
gene id: 521097:COCH_RS04980
uniprot id: C7M3W1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02085
gene id: 521097:COCH_RS02085
uniprot id: C7M6I8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

521097:COCH RS00390
gene id: 521097:COCH_RS00390
uniprot id: C7M4K9
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS01795
gene id: 521097:COCH_RS01795
uniprot id: C7M642
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00150
gene id: 521097:COCH_RS00150
uniprot id: C7M4G5
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

521097:COCH RS00205
gene id: 521097:COCH_RS00205
uniprot id: C7M4H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

521097:COCH RS01885
gene id: 521097:COCH_RS01885
uniprot id: C7M660
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05765
gene id: 521097:COCH_RS05765
uniprot id: C7M4R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

521097:COCH RS01790
gene id: 521097:COCH_RS01790
uniprot id: C7M641
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

521097:COCH RS05845
gene id: 521097:COCH_RS05845
uniprot id: C7M4S7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

521097:COCH RS02225
gene id: 521097:COCH_RS02225
uniprot id: C7M6L5
names: Similarity
messages: Belongs to the sulfatase family.

521097:COCH RS08775
gene id: 521097:COCH_RS08775
uniprot id: C7M830
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

521097:COCH RS05170
gene id: 521097:COCH_RS05170
uniprot id: C7M3Z8
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

521097:COCH RS05050
gene id: 521097:COCH_RS05050
uniprot id: C7M3X4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521097:COCH RS00735
gene id: 521097:COCH_RS00735
uniprot id: C7M511
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

521097:COCH RS04585
gene id: 521097:COCH_RS04585
uniprot id: C7M9C0
names: Similarity
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

521097:COCH RS05735
gene id: 521097:COCH_RS05735
uniprot id: C7M4E0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521097:COCH RS07925
gene id: 521097:COCH_RS07925
uniprot id: C7M6Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS10170
gene id: 521097:COCH_RS10170
uniprot id: C7M9H0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS01470
gene id: 521097:COCH_RS01470
uniprot id: C7M5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

521097:COCH RS07890
gene id: 521097:COCH_RS07890
uniprot id: C7M6Y4
names: Similarity
messages: Belongs to the ParB family.

521097:COCH RS08815
gene id: 521097:COCH_RS08815
uniprot id: C7M838
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521097:COCH RS04875
gene id: 521097:COCH_RS04875
uniprot id: C7M412
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

521097:COCH RS04570
gene id: 521097:COCH_RS04570
uniprot id: C7M9B7
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

521097:COCH RS06555
gene id: 521097:COCH_RS06555
uniprot id: C7M5F0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS04135
gene id: 521097:COCH_RS04135
uniprot id: C7M929
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

521097:COCH RS06890
gene id: 521097:COCH_RS06890
uniprot id: C7M5W3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

521097:COCH RS08365
gene id: 521097:COCH_RS08365
uniprot id: C7M7C4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

521097:COCH RS03100
gene id: 521097:COCH_RS03100
uniprot id: C7M7L1
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

521097:COCH RS05840
gene id: 521097:COCH_RS05840
uniprot id: C7M4S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

521097:COCH RS08990
gene id: 521097:COCH_RS08990
uniprot id: C7M873
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

521097:COCH RS08340
gene id: 521097:COCH_RS08340
uniprot id: C7M7B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

521097:COCH RS10985
gene id: 521097:COCH_RS10985
uniprot id: C7M3U1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

521097:COCH RS01135
gene id: 521097:COCH_RS01135
uniprot id: C7M5H5
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05575
gene id: 521097:COCH_RS05575
uniprot id: C7M4A9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

521097:COCH RS06250
gene id: 521097:COCH_RS06250
uniprot id: C7M589
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05095
gene id: 521097:COCH_RS05095
uniprot id: C7M3Y3
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

521097:COCH RS08935
gene id: 521097:COCH_RS08935
uniprot id: C7M863
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00295
gene id: 521097:COCH_RS00295
uniprot id: C7M4J0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

521097:COCH RS03025
gene id: 521097:COCH_RS03025
uniprot id: C7M7J7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07440
gene id: 521097:COCH_RS07440
uniprot id: C7M6G3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

521097:COCH RS09795
gene id: 521097:COCH_RS09795
uniprot id: C7M8V3
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

521097:COCH RS09230
gene id: 521097:COCH_RS09230
uniprot id: C7M8K1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02930
gene id: 521097:COCH_RS02930
uniprot id: C7M7H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

521097:COCH RS00160
gene id: 521097:COCH_RS00160
uniprot id: C7M4G7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

521097:COCH RS02790
gene id: 521097:COCH_RS02790
uniprot id: C7M7F1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

521097:COCH RS10615
gene id: 521097:COCH_RS10615
uniprot id: C7M3L6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

521097:COCH RS05860
gene id: 521097:COCH_RS05860
uniprot id: C7M4T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

521097:COCH RS03030
gene id: 521097:COCH_RS03030
uniprot id: C7M7J8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08180
gene id: 521097:COCH_RS08180
uniprot id: C7M787
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

521097:COCH RS10645
gene id: 521097:COCH_RS10645
uniprot id: C7M3M2
names: Similarity
messages: Belongs to the HSP15 family.

521097:COCH RS00905
gene id: 521097:COCH_RS00905
uniprot id: C7M544
names: Caution
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

521097:COCH RS10005
gene id: 521097:COCH_RS10005
uniprot id: C7M8Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

521097:COCH RS02345
gene id: 521097:COCH_RS02345
uniprot id: C7M6N8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

521097:COCH RS02685
gene id: 521097:COCH_RS02685
uniprot id: C7M734
names: Similarity
messages: Belongs to the YciI family.

521097:COCH RS01895
gene id: 521097:COCH_RS01895
uniprot id: C7M662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

521097:COCH RS06110
gene id: 521097:COCH_RS06110
uniprot id: C7M4X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VapD ribonuclease family.
messages: Cleaves ssRNA, mostly between U:A.
messages: Homodimer.

521097:COCH RS05425
gene id: 521097:COCH_RS05425
uniprot id: C7M479
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS09095
gene id: 521097:COCH_RS09095
uniprot id: C7M893
names: Similarity
messages: Belongs to the sulfatase family.

521097:COCH RS07460
gene id: 521097:COCH_RS07460
uniprot id: C7M6G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS09105
gene id: 521097:COCH_RS09105
uniprot id: C7M895
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

521097:COCH RS03200
gene id: 521097:COCH_RS03200
uniprot id: C7M7T3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

521097:COCH RS07325
gene id: 521097:COCH_RS07325
uniprot id: C7M6E0
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09425
gene id: 521097:COCH_RS09425
uniprot id: C7M8N6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

521097:COCH RS06125
gene id: 521097:COCH_RS06125
uniprot id: C7M4X8
names: Similarity
messages: Belongs to the peptidase M24B family.

521097:COCH RS05360
gene id: 521097:COCH_RS05360
uniprot id: C7M465
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS03840
gene id: 521097:COCH_RS03840
uniprot id: C7M8E4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS10770
gene id: 521097:COCH_RS10770
uniprot id: C7M3P7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

521097:COCH RS06715
gene id: 521097:COCH_RS06715
uniprot id: C7M5S5
names: Subcellular Location Annotation
messages: Cytoplasm

521097:COCH RS06695
gene id: 521097:COCH_RS06695
uniprot id: C7M5S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

521097:COCH RS07220
gene id: 521097:COCH_RS07220
uniprot id: C7M6C4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

521097:COCH RS01750
gene id: 521097:COCH_RS01750
uniprot id: C7M633
names: Similarity
messages: Belongs to the RecJ family.

521097:COCH RS10825
gene id: 521097:COCH_RS10825
uniprot id: C7M3Q8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

521097:COCH RS05790
gene id: 521097:COCH_RS05790
uniprot id: C7M4R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

521097:COCH RS00015
gene id: 521097:COCH_RS00015
uniprot id: C7M437
names: Similarity
messages: Belongs to the peptidase S41A family.

521097:COCH RS06055
gene id: 521097:COCH_RS06055
uniprot id: C7M4W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VapD ribonuclease family.
messages: Cleaves ssRNA, mostly between U:A.
messages: Homodimer.

521097:COCH RS00210
gene id: 521097:COCH_RS00210
uniprot id: C7M4H4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

521097:COCH RS00775
gene id: 521097:COCH_RS00775
uniprot id: C7M520
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08015
gene id: 521097:COCH_RS08015
uniprot id: C7M755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS10470
gene id: 521097:COCH_RS10470
uniprot id: C7M3I6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

521097:COCH RS11005
gene id: 521097:COCH_RS11005
uniprot id: C7M4E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

521097:COCH RS04270
gene id: 521097:COCH_RS04270
uniprot id: C7M957
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

521097:COCH RS05755
gene id: 521097:COCH_RS05755
uniprot id: C7M4Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

521097:COCH RS01000
gene id: 521097:COCH_RS01000
uniprot id: C7M560
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS03495
gene id: 521097:COCH_RS03495
uniprot id: C7M7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class A bacterial acid phosphatase family.
messages: Periplasm

521097:COCH RS01240
gene id: 521097:COCH_RS01240
uniprot id: C7M5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

521097:COCH RS00575
gene id: 521097:COCH_RS00575
uniprot id: C7M4P7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08920
gene id: 521097:COCH_RS08920
uniprot id: C7M859
names: Similarity
messages: Belongs to the isochorismate synthase family.

521097:COCH RS02315
gene id: 521097:COCH_RS02315
uniprot id: C7M6N3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

521097:COCH RS01475
gene id: 521097:COCH_RS01475
uniprot id: C7M5P5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

521097:COCH RS10915
gene id: 521097:COCH_RS10915
uniprot id: C7M3S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS02390
gene id: 521097:COCH_RS02390
uniprot id: C7M6P7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08430
gene id: 521097:COCH_RS08430
uniprot id: C7M7D7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

521097:COCH RS05025
gene id: 521097:COCH_RS05025
uniprot id: C7M3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

521097:COCH RS06145
gene id: 521097:COCH_RS06145
uniprot id: C7M4Y3
names: Similarity
messages: Belongs to the peptidase S49 family.

521097:COCH RS02630
gene id: 521097:COCH_RS02630
uniprot id: C7M722
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS09205
gene id: 521097:COCH_RS09205
uniprot id: C7M8J6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS02450
gene id: 521097:COCH_RS02450
uniprot id: C7M6Q4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

521097:COCH RS08830
gene id: 521097:COCH_RS08830
uniprot id: C7M841
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

521097:COCH RS04895
gene id: 521097:COCH_RS04895
uniprot id: C7M3U4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS04825
gene id: 521097:COCH_RS04825
uniprot id: C7M3G8
names: Similarity
messages: Belongs to the glutamine synthetase family.

521097:COCH RS07025
gene id: 521097:COCH_RS07025
uniprot id: C7M5Z0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

521097:COCH RS08630
gene id: 521097:COCH_RS08630
uniprot id: C7M7R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

521097:COCH RS05490
gene id: 521097:COCH_RS05490
uniprot id: C7M492
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

521097:COCH RS01595
gene id: 521097:COCH_RS01595
uniprot id: C7M602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

521097:COCH RS00710
gene id: 521097:COCH_RS00710
uniprot id: C7M506
names: Similarity
messages: Belongs to the peptidase M16 family.

521097:COCH RS06640
gene id: 521097:COCH_RS06640
uniprot id: C7M5R1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS10550
gene id: 521097:COCH_RS10550
uniprot id: C7M3K2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

521097:COCH RS09930
gene id: 521097:COCH_RS09930
uniprot id: C7M8Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

521097:COCH RS04740
gene id: 521097:COCH_RS04740
uniprot id: C7M3F2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

521097:COCH RS10765
gene id: 521097:COCH_RS10765
uniprot id: C7M3P6
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07300
gene id: 521097:COCH_RS07300
uniprot id: C7M6D4
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

521097:COCH RS09040
gene id: 521097:COCH_RS09040
uniprot id: C7M882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS09315
gene id: 521097:COCH_RS09315
uniprot id: C7M8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

521097:COCH RS01985
gene id: 521097:COCH_RS01985
uniprot id: C7M679
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

521097:COCH RS10090
gene id: 521097:COCH_RS10090
uniprot id: C7M9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

521097:COCH RS02625
gene id: 521097:COCH_RS02625
uniprot id: C7M721
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

521097:COCH RS01395
gene id: 521097:COCH_RS01395
uniprot id: C7M5M8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

521097:COCH RS03800
gene id: 521097:COCH_RS03800
uniprot id: C7M8D8
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

521097:COCH RS03620
gene id: 521097:COCH_RS03620
uniprot id: C7M8A4
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

521097:COCH RS01650
gene id: 521097:COCH_RS01650
uniprot id: C7M613
names: Similarity
messages: Belongs to the Dps family.

521097:COCH RS02010
gene id: 521097:COCH_RS02010
uniprot id: C7M6H3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

521097:COCH RS00385
gene id: 521097:COCH_RS00385
uniprot id: C7M4K8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS01435
gene id: 521097:COCH_RS01435
uniprot id: C7M5N7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS04990
gene id: 521097:COCH_RS04990
uniprot id: C7M3W2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS08315
gene id: 521097:COCH_RS08315
uniprot id: C7M7B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

521097:COCH RS05975
gene id: 521097:COCH_RS05975
uniprot id: C7M4V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

521097:COCH RS00395
gene id: 521097:COCH_RS00395
uniprot id: C7M4L0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

521097:COCH RS08700
gene id: 521097:COCH_RS08700
uniprot id: C7M814
names: Similarity
messages: Belongs to the peptidase C1 family.

521097:COCH RS04620
gene id: 521097:COCH_RS04620
uniprot id: C7M9C7
names: Similarity
messages: Belongs to the NAD synthetase family.

521097:COCH RS03440
gene id: 521097:COCH_RS03440
uniprot id: C7M7Y1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521097:COCH RS04230
gene id: 521097:COCH_RS04230
uniprot id: C7M949
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

521097:COCH RS07060
gene id: 521097:COCH_RS07060
uniprot id: C7M690
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

521097:COCH RS01535
gene id: 521097:COCH_RS01535
uniprot id: C7M5Q7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

521097:COCH RS07495
gene id: 521097:COCH_RS07495
uniprot id: C7M6R4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS09685
gene id: 521097:COCH_RS09685
uniprot id: C7M8T0
names: Similarity
messages: Belongs to the YoeB family.

521097:COCH RS09225
gene id: 521097:COCH_RS09225
uniprot id: C7M8K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

521097:COCH RS09350
gene id: 521097:COCH_RS09350
uniprot id: C7M8M6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

521097:COCH RS09950
gene id: 521097:COCH_RS09950
uniprot id: C7M8Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form.

521097:COCH RS04920
gene id: 521097:COCH_RS04920
uniprot id: C7M3U9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS06630
gene id: 521097:COCH_RS06630
uniprot id: C7M5Q9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

521097:COCH RS09880
gene id: 521097:COCH_RS09880
uniprot id: C7M8W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

521097:COCH RS02205
gene id: 521097:COCH_RS02205
uniprot id: C7M6L1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS06060
gene id: 521097:COCH_RS06060
uniprot id: C7M4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

521097:COCH RS11480
gene id: 521097:COCH_RS11480
uniprot id: C7M4T2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

521097:COCH RS08120
gene id: 521097:COCH_RS08120
uniprot id: C7M775
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

521097:COCH RS03155
gene id: 521097:COCH_RS03155
uniprot id: C7M7M2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS07530
gene id: 521097:COCH_RS07530
uniprot id: C7M6S0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS04910
gene id: 521097:COCH_RS04910
uniprot id: C7M3U7
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

521097:COCH RS06355
gene id: 521097:COCH_RS06355
uniprot id: C7M5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

521097:COCH RS04600
gene id: 521097:COCH_RS04600
uniprot id: C7M9C3
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00455
gene id: 521097:COCH_RS00455
uniprot id: C7M4M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS06985
gene id: 521097:COCH_RS06985
uniprot id: C7M5Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

521097:COCH RS00335
gene id: 521097:COCH_RS00335
uniprot id: C7M4J8
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

521097:COCH RS03985
gene id: 521097:COCH_RS03985
uniprot id: C7M8H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521097:COCH RS01830
gene id: 521097:COCH_RS01830
uniprot id: C7M649
names: Similarity
messages: Belongs to the UPF0246 family.

521097:COCH RS00790
gene id: 521097:COCH_RS00790
uniprot id: C7M523
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

521097:COCH RS06575
gene id: 521097:COCH_RS06575
uniprot id: C7M5F4
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS07085
gene id: 521097:COCH_RS07085
uniprot id: C7M696
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

521097:COCH RS03990
gene id: 521097:COCH_RS03990
uniprot id: C7M8H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

521097:COCH RS04770
gene id: 521097:COCH_RS04770
uniprot id: C7M3F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521097:COCH RS02465
gene id: 521097:COCH_RS02465
uniprot id: C7M6Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

521097:COCH RS10430
gene id: 521097:COCH_RS10430
uniprot id: C7M3H8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521097:COCH RS08650
gene id: 521097:COCH_RS08650
uniprot id: C7M7S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS08400
gene id: 521097:COCH_RS08400
uniprot id: C7M7D1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

521097:COCH RS10660
gene id: 521097:COCH_RS10660
uniprot id: C7M3M5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

521097:COCH RS05795
gene id: 521097:COCH_RS05795
uniprot id: C7M4R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

521097:COCH RS09535
gene id: 521097:COCH_RS09535
uniprot id: C7M8Q4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

521097:COCH RS02870
gene id: 521097:COCH_RS02870
uniprot id: C7M7G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

521097:COCH RS04880
gene id: 521097:COCH_RS04880
uniprot id: C7M413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Mitochondrion

521097:COCH RS05750
gene id: 521097:COCH_RS05750
uniprot id: C7M4Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

521097:COCH RS01685
gene id: 521097:COCH_RS01685
uniprot id: C7M620
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

521097:COCH RS08240
gene id: 521097:COCH_RS08240
uniprot id: C7M799
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

521097:COCH RS09345
gene id: 521097:COCH_RS09345
uniprot id: C7M8M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

521097:COCH RS04440
gene id: 521097:COCH_RS04440
uniprot id: C7M992
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

521097:COCH RS07335
gene id: 521097:COCH_RS07335
uniprot id: C7M6E2
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS04930
gene id: 521097:COCH_RS04930
uniprot id: C7M3V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

521097:COCH RS01010
gene id: 521097:COCH_RS01010
uniprot id: C7M562
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS09785
gene id: 521097:COCH_RS09785
uniprot id: C7M8V1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

521097:COCH RS09600
gene id: 521097:COCH_RS09600
uniprot id: C7M8R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

521097:COCH RS08840
gene id: 521097:COCH_RS08840
uniprot id: C7M843
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

521097:COCH RS04035
gene id: 521097:COCH_RS04035
uniprot id: C7M909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

521097:COCH RS10870
gene id: 521097:COCH_RS10870
uniprot id: C7M3R8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

521097:COCH RS08980
gene id: 521097:COCH_RS08980
uniprot id: C7M871
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

521097:COCH RS10165
gene id: 521097:COCH_RS10165
uniprot id: C7M9G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

521097:COCH RS10245
gene id: 521097:COCH_RS10245
uniprot id: C7M9I5
names: Similarity
messages: Belongs to the UPF0102 family.

521097:COCH RS00950
gene id: 521097:COCH_RS00950
uniprot id: C7M550
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

521097:COCH RS09430
gene id: 521097:COCH_RS09430
uniprot id: C7M8N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

521097:COCH RS10580
gene id: 521097:COCH_RS10580
uniprot id: C7M3K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

521097:COCH RS05550
gene id: 521097:COCH_RS05550
uniprot id: C7M4A4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02545
gene id: 521097:COCH_RS02545
uniprot id: C7M707
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521097:COCH RS10630
gene id: 521097:COCH_RS10630
uniprot id: C7M3L9
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08965
gene id: 521097:COCH_RS08965
uniprot id: C7M868
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

521097:COCH RS10045
gene id: 521097:COCH_RS10045
uniprot id: C7M8Z9
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00220
gene id: 521097:COCH_RS00220
uniprot id: C7M4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

521097:COCH RS09310
gene id: 521097:COCH_RS09310
uniprot id: C7M8L7
names: Similarity
messages: Belongs to the aldose epimerase family.

521097:COCH RS10965
gene id: 521097:COCH_RS10965
uniprot id: C7M3T7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

521097:COCH RS07585
gene id: 521097:COCH_RS07585
uniprot id: C7M6T0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

521097:COCH RS06515
gene id: 521097:COCH_RS06515
uniprot id: C7M5E2
names: Similarity
messages: Belongs to the OsmC/Ohr family.

521097:COCH RS02280
gene id: 521097:COCH_RS02280
uniprot id: C7M6M6
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

521097:COCH RS10075
gene id: 521097:COCH_RS10075
uniprot id: C7M9F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

521097:COCH RS06225
gene id: 521097:COCH_RS06225
uniprot id: C7M584
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

521097:COCH RS08135
gene id: 521097:COCH_RS08135
uniprot id: C7M778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

521097:COCH RS06655
gene id: 521097:COCH_RS06655
uniprot id: C7M5R4
names: Similarity
messages: Belongs to the sulfatase family.

521097:COCH RS08040
gene id: 521097:COCH_RS08040
uniprot id: C7M760
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

521097:COCH RS01175
gene id: 521097:COCH_RS01175
uniprot id: C7M5I3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

521097:COCH RS05325
gene id: 521097:COCH_RS05325
uniprot id: C7M458
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

521097:COCH RS10150
gene id: 521097:COCH_RS10150
uniprot id: C7M9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

521097:COCH RS00565
gene id: 521097:COCH_RS00565
uniprot id: C7M4P5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

521097:COCH RS07090
gene id: 521097:COCH_RS07090
uniprot id: C7M697
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

521097:COCH RS11245
gene id: 521097:COCH_RS11245
uniprot id: C7M5N2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

521097:COCH RS09075
gene id: 521097:COCH_RS09075
uniprot id: C7M889
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

521097:COCH RS01335
gene id: 521097:COCH_RS01335
uniprot id: C7M5L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

521097:COCH RS04635
gene id: 521097:COCH_RS04635
uniprot id: C7M9D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

521097:COCH RS11075
gene id: 521097:COCH_RS11075
uniprot id: C7M4F8
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

521097:COCH RS00425
gene id: 521097:COCH_RS00425
uniprot id: C7M4L6
names: Similarity
messages: Belongs to the peptidase S51 family.

521097:COCH RS08405
gene id: 521097:COCH_RS08405
uniprot id: C7M7D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

521097:COCH RS01320
gene id: 521097:COCH_RS01320
uniprot id: C7M5L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

521097:COCH RS06785
gene id: 521097:COCH_RS06785
uniprot id: C7M5U1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

521097:COCH RS01265
gene id: 521097:COCH_RS01265
uniprot id: C7M5K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

521097:COCH RS01405
gene id: 521097:COCH_RS01405
uniprot id: C7M5N0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

521097:COCH RS07415
gene id: 521097:COCH_RS07415
uniprot id: C7M6F9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

521097:COCH RS03375
gene id: 521097:COCH_RS03375
uniprot id: C7M7W9
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS09280
gene id: 521097:COCH_RS09280
uniprot id: C7M8L1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

521097:COCH RS06385
gene id: 521097:COCH_RS06385
uniprot id: C7M5B4
names: Similarity
messages: Belongs to the universal stress protein A family.

521097:COCH RS10775
gene id: 521097:COCH_RS10775
uniprot id: C7M3P8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

521097:COCH RS05150
gene id: 521097:COCH_RS05150
uniprot id: C7M3Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

521097:COCH RS03645
gene id: 521097:COCH_RS03645
uniprot id: C7M8A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

521097:COCH RS06860
gene id: 521097:COCH_RS06860
uniprot id: C7M5V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

521097:COCH RS10345
gene id: 521097:COCH_RS10345
uniprot id: C7M9K4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

521097:COCH RS06610
gene id: 521097:COCH_RS06610
uniprot id: C7M5G1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

521097:COCH RS02475
gene id: 521097:COCH_RS02475
uniprot id: C7M6Q9
names: Similarity
messages: Belongs to the nitroreductase family.

521097:COCH RS02210
gene id: 521097:COCH_RS02210
uniprot id: C7M6L2
names: Similarity
messages: Belongs to the peptidase S8 family.

521097:COCH RS08760
gene id: 521097:COCH_RS08760
uniprot id: C7M826
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

521097:COCH RS00645
gene id: 521097:COCH_RS00645
uniprot id: C7M4Z2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

521097:COCH RS04560
gene id: 521097:COCH_RS04560
uniprot id: C7M9B5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

521097:COCH RS06405
gene id: 521097:COCH_RS06405
uniprot id: C7M5B8
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

521097:COCH RS01095
gene id: 521097:COCH_RS01095
uniprot id: C7M5G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

521097:COCH RS10450
gene id: 521097:COCH_RS10450
uniprot id: C7M3I2
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09355
gene id: 521097:COCH_RS09355
uniprot id: C7M8M7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

521097:COCH RS07780
gene id: 521097:COCH_RS07780
uniprot id: C7M6W3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS06115
gene id: 521097:COCH_RS06115
uniprot id: C7M4X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

521097:COCH RS07505
gene id: 521097:COCH_RS07505
uniprot id: C7M6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

521097:COCH RS05865
gene id: 521097:COCH_RS05865
uniprot id: C7M4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

521097:COCH RS10785
gene id: 521097:COCH_RS10785
uniprot id: C7M3P9
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

521097:COCH RS03355
gene id: 521097:COCH_RS03355
uniprot id: C7M7W5
names: Similarity
messages: Belongs to the DprA/Smf family.

521097:COCH RS10515
gene id: 521097:COCH_RS10515
uniprot id: C7M3J5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

521097:COCH RS05085
gene id: 521097:COCH_RS05085
uniprot id: C7M3Y1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

521097:COCH RS05430
gene id: 521097:COCH_RS05430
uniprot id: C7M480
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

521097:COCH RS08565
gene id: 521097:COCH_RS08565
uniprot id: C7M7Q2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

521097:COCH RS00080
gene id: 521097:COCH_RS00080
uniprot id: C7M449
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

521097:COCH RS01600
gene id: 521097:COCH_RS01600
uniprot id: C7M603
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

521097:COCH RS04675
gene id: 521097:COCH_RS04675
uniprot id: C7M9E0
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS07685
gene id: 521097:COCH_RS07685
uniprot id: C7M6U7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00870
gene id: 521097:COCH_RS00870
uniprot id: C7M537
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

521097:COCH RS01325
gene id: 521097:COCH_RS01325
uniprot id: C7M5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

521097:COCH RS06740
gene id: 521097:COCH_RS06740
uniprot id: C7M5T1
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS05785
gene id: 521097:COCH_RS05785
uniprot id: C7M4R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

521097:COCH RS02725
gene id: 521097:COCH_RS02725
uniprot id: C7M7E0
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS05745
gene id: 521097:COCH_RS05745
uniprot id: C7M4Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

521097:COCH RS01935
gene id: 521097:COCH_RS01935
uniprot id: C7M669
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05220
gene id: 521097:COCH_RS05220
uniprot id: C7M407
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

521097:COCH RS04915
gene id: 521097:COCH_RS04915
uniprot id: C7M3U8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05885
gene id: 521097:COCH_RS05885
uniprot id: C7M4T6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

521097:COCH RS06620
gene id: 521097:COCH_RS06620
uniprot id: C7M5G3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

521097:COCH RS08095
gene id: 521097:COCH_RS08095
uniprot id: C7M770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS07355
gene id: 521097:COCH_RS07355
uniprot id: C7M6E6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

521097:COCH RS01445
gene id: 521097:COCH_RS01445
uniprot id: C7M5N9
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

521097:COCH RS06065
gene id: 521097:COCH_RS06065
uniprot id: C7M4X1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

521097:COCH RS03135
gene id: 521097:COCH_RS03135
uniprot id: C7M7L8
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

521097:COCH RS02145
gene id: 521097:COCH_RS02145
uniprot id: C7M6K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

521097:COCH RS02830
gene id: 521097:COCH_RS02830
uniprot id: C7M7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

521097:COCH RS06905
gene id: 521097:COCH_RS06905
uniprot id: C7M5W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS10520
gene id: 521097:COCH_RS10520
uniprot id: C7M3J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

521097:COCH RS06690
gene id: 521097:COCH_RS06690
uniprot id: C7M5S1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS04615
gene id: 521097:COCH_RS04615
uniprot id: C7M9C6
names: Similarity
messages: Belongs to the UPF0758 family.

521097:COCH RS02040
gene id: 521097:COCH_RS02040
uniprot id: C7M6H9
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

521097:COCH RS10010
gene id: 521097:COCH_RS10010
uniprot id: C7M8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

521097:COCH RS09365
gene id: 521097:COCH_RS09365
uniprot id: C7M8M9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS08220
gene id: 521097:COCH_RS08220
uniprot id: C7M795
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08435
gene id: 521097:COCH_RS08435
uniprot id: C7M7D8
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

521097:COCH RS07195
gene id: 521097:COCH_RS07195
uniprot id: C7M6B8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00960
gene id: 521097:COCH_RS00960
uniprot id: C7M552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

521097:COCH RS05800
gene id: 521097:COCH_RS05800
uniprot id: C7M4R8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

521097:COCH RS04785
gene id: 521097:COCH_RS04785
uniprot id: C7M3G0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS05140
gene id: 521097:COCH_RS05140
uniprot id: C7M3Z2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS06625
gene id: 521097:COCH_RS06625
uniprot id: C7M5Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

521097:COCH RS08505
gene id: 521097:COCH_RS08505
uniprot id: C7M7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

521097:COCH RS05850
gene id: 521097:COCH_RS05850
uniprot id: C7M4S8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

521097:COCH RS03630
gene id: 521097:COCH_RS03630
uniprot id: C7M8A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

521097:COCH RS07905
gene id: 521097:COCH_RS07905
uniprot id: C7M6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane
messages: Membrane

521097:COCH RS01105
gene id: 521097:COCH_RS01105
uniprot id: C7M5G9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

521097:COCH RS03875
gene id: 521097:COCH_RS03875
uniprot id: C7M8F2
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

521097:COCH RS10445
gene id: 521097:COCH_RS10445
uniprot id: C7M3I1
names: Similarity
messages: Belongs to the DapA family.

521097:COCH RS00130
gene id: 521097:COCH_RS00130
uniprot id: C7M4G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

521097:COCH RS00235
gene id: 521097:COCH_RS00235
uniprot id: C7M4H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

521097:COCH RS00100
gene id: 521097:COCH_RS00100
uniprot id: C7M453
names: Similarity
messages: Belongs to the heat shock protein 90 family.

521097:COCH RS05890
gene id: 521097:COCH_RS05890
uniprot id: C7M4T7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

521097:COCH RS05760
gene id: 521097:COCH_RS05760
uniprot id: C7M4R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

521097:COCH RS08540
gene id: 521097:COCH_RS08540
uniprot id: C7M7P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

521097:COCH RS05775
gene id: 521097:COCH_RS05775
uniprot id: C7M4R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

521097:COCH RS03950
gene id: 521097:COCH_RS03950
uniprot id: C7M8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

521097:COCH RS07380
gene id: 521097:COCH_RS07380
uniprot id: C7M6F2
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS02265
gene id: 521097:COCH_RS02265
uniprot id: C7M6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS01115
gene id: 521097:COCH_RS01115
uniprot id: C7M5H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

521097:COCH RS06035
gene id: 521097:COCH_RS06035
uniprot id: C7M4W5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

521097:COCH RS09765
gene id: 521097:COCH_RS09765
uniprot id: C7M8U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

521097:COCH RS06395
gene id: 521097:COCH_RS06395
uniprot id: C7M5B6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

521097:COCH RS01160
gene id: 521097:COCH_RS01160
uniprot id: C7M5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS09975
gene id: 521097:COCH_RS09975
uniprot id: C7M8Y8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

521097:COCH RS10115
gene id: 521097:COCH_RS10115
uniprot id: C7M9F8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

521097:COCH RS10315
gene id: 521097:COCH_RS10315
uniprot id: C7M9J8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

521097:COCH RS05690
gene id: 521097:COCH_RS05690
uniprot id: C7M4D2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521097:COCH RS05805
gene id: 521097:COCH_RS05805
uniprot id: C7M4R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

521097:COCH RS09215
gene id: 521097:COCH_RS09215
uniprot id: C7M8J8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

521097:COCH RS07310
gene id: 521097:COCH_RS07310
uniprot id: C7M6D6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

521097:COCH RS08270
gene id: 521097:COCH_RS08270
uniprot id: C7M7A5
names: Similarity
messages: Belongs to the UPF0310 family.

521097:COCH RS01210
gene id: 521097:COCH_RS01210
uniprot id: C7M5J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

521097:COCH RS05155
gene id: 521097:COCH_RS05155
uniprot id: C7M3Z5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

521097:COCH RS10895
gene id: 521097:COCH_RS10895
uniprot id: C7M3S4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

521097:COCH RS03185
gene id: 521097:COCH_RS03185
uniprot id: C7M7T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS04110
gene id: 521097:COCH_RS04110
uniprot id: C7M924
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10850
gene id: 521097:COCH_RS10850
uniprot id: C7M3R4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07255
gene id: 521097:COCH_RS07255
uniprot id: C7M6C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

521097:COCH RS00185
gene id: 521097:COCH_RS00185
uniprot id: C7M4H0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

521097:COCH RS08945
gene id: 521097:COCH_RS08945
uniprot id: C7M864
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

521097:COCH RS04885
gene id: 521097:COCH_RS04885
uniprot id: C7M414
names: Similarity
messages: Belongs to the TPP enzyme family.

521097:COCH RS03905
gene id: 521097:COCH_RS03905
uniprot id: C7M8F8
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

521097:COCH RS11025
gene id: 521097:COCH_RS11025
uniprot id: C7M4E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required for cell division and gliding motility.

521097:COCH RS06455
gene id: 521097:COCH_RS06455
uniprot id: C7M5D0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

521097:COCH RS09155
gene id: 521097:COCH_RS09155
uniprot id: C7M8I6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS07450
gene id: 521097:COCH_RS07450
uniprot id: C7M6G5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05770
gene id: 521097:COCH_RS05770
uniprot id: C7M4R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

521097:COCH RS00605
gene id: 521097:COCH_RS00605
uniprot id: C7M4Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

521097:COCH RS06855
gene id: 521097:COCH_RS06855
uniprot id: C7M5V6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

521097:COCH RS10420
gene id: 521097:COCH_RS10420
uniprot id: C7M3H6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

521097:COCH RS00850
gene id: 521097:COCH_RS00850
uniprot id: C7M533
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521097:COCH RS04640
gene id: 521097:COCH_RS04640
uniprot id: C7M9D2
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

521097:COCH RS10030
gene id: 521097:COCH_RS10030
uniprot id: C7M8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

521097:COCH RS03650
gene id: 521097:COCH_RS03650
uniprot id: C7M8A9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

521097:COCH RS05115
gene id: 521097:COCH_RS05115
uniprot id: C7M3Y7
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

521097:COCH RS09970
gene id: 521097:COCH_RS09970
uniprot id: C7M8Y7
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

521097:COCH RS08345
gene id: 521097:COCH_RS08345
uniprot id: C7M7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

521097:COCH RS07180
gene id: 521097:COCH_RS07180
uniprot id: C7M6B5
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS06045
gene id: 521097:COCH_RS06045
uniprot id: C7M4W7
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

521097:COCH RS10185
gene id: 521097:COCH_RS10185
uniprot id: C7M9H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

521097:COCH RS10440
gene id: 521097:COCH_RS10440
uniprot id: C7M3I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS05725
gene id: 521097:COCH_RS05725
uniprot id: C7M4D8
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS04155
gene id: 521097:COCH_RS04155
uniprot id: C7M933
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07820
gene id: 521097:COCH_RS07820
uniprot id: C7M6X1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09865
gene id: 521097:COCH_RS09865
uniprot id: C7M8W6
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

521097:COCH RS07545
gene id: 521097:COCH_RS07545
uniprot id: C7M6S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

521097:COCH RS00980
gene id: 521097:COCH_RS00980
uniprot id: C7M556
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

521097:COCH RS05125
gene id: 521097:COCH_RS05125
uniprot id: C7M3Y9
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS02130
gene id: 521097:COCH_RS02130
uniprot id: C7M6J7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

521097:COCH RS07350
gene id: 521097:COCH_RS07350
uniprot id: C7M6E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

521097:COCH RS09260
gene id: 521097:COCH_RS09260
uniprot id: C7M8K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

521097:COCH RS09830
gene id: 521097:COCH_RS09830
uniprot id: C7M8W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00515
gene id: 521097:COCH_RS00515
uniprot id: C7M4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

521097:COCH RS02440
gene id: 521097:COCH_RS02440
uniprot id: C7M6Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

521097:COCH RS09135
gene id: 521097:COCH_RS09135
uniprot id: C7M8I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

521097:COCH RS08225
gene id: 521097:COCH_RS08225
uniprot id: C7M796
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05465
gene id: 521097:COCH_RS05465
uniprot id: C7M487
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

521097:COCH RS06350
gene id: 521097:COCH_RS06350
uniprot id: C7M5A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

521097:COCH RS02490
gene id: 521097:COCH_RS02490
uniprot id: C7M6R2
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

521097:COCH RS09485
gene id: 521097:COCH_RS09485
uniprot id: C7M8P7
names: Similarity
messages: Belongs to the ArsC family.

521097:COCH RS09305
gene id: 521097:COCH_RS09305
uniprot id: C7M8L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

521097:COCH RS00485
gene id: 521097:COCH_RS00485
uniprot id: C7M4M9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

521097:COCH RS09595
gene id: 521097:COCH_RS09595
uniprot id: C7M8R3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS08395
gene id: 521097:COCH_RS08395
uniprot id: C7M7D0
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

521097:COCH RS00635
gene id: 521097:COCH_RS00635
uniprot id: C7M4Y9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

521097:COCH RS09000
gene id: 521097:COCH_RS09000
uniprot id: C7M875
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

521097:COCH RS02500
gene id: 521097:COCH_RS02500
uniprot id: C7M6Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS05545
gene id: 521097:COCH_RS05545
uniprot id: C7M4A3
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07290
gene id: 521097:COCH_RS07290
uniprot id: C7M6D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

521097:COCH RS06660
gene id: 521097:COCH_RS06660
uniprot id: C7M5R5
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS08250
gene id: 521097:COCH_RS08250
uniprot id: C7M7A1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

521097:COCH RS10845
gene id: 521097:COCH_RS10845
uniprot id: C7M3R3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

521097:COCH RS03690
gene id: 521097:COCH_RS03690
uniprot id: C7M8B7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

521097:COCH RS05825
gene id: 521097:COCH_RS05825
uniprot id: C7M4S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

521097:COCH RS01675
gene id: 521097:COCH_RS01675
uniprot id: C7M618
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

521097:COCH RS05875
gene id: 521097:COCH_RS05875
uniprot id: C7M4T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

521097:COCH RS05055
gene id: 521097:COCH_RS05055
uniprot id: C7M3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

521097:COCH RS06770
gene id: 521097:COCH_RS06770
uniprot id: C7M5T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

521097:COCH RS07040
gene id: 521097:COCH_RS07040
uniprot id: C7M686
names: Similarity
messages: Belongs to the MreC family.

521097:COCH RS10395
gene id: 521097:COCH_RS10395
uniprot id: C7M9L4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

521097:COCH RS10590
gene id: 521097:COCH_RS10590
uniprot id: C7M3L0
names: Similarity
messages: Belongs to the peptidase S1C family.

521097:COCH RS07755
gene id: 521097:COCH_RS07755
uniprot id: C7M6V8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

521097:COCH RS03480
gene id: 521097:COCH_RS03480
uniprot id: C7M7Z0
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS10605
gene id: 521097:COCH_RS10605
uniprot id: C7M3L3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS04090
gene id: 521097:COCH_RS04090
uniprot id: C7M920
names: Similarity
messages: Belongs to the peptidase S9A family.

521097:COCH RS08520
gene id: 521097:COCH_RS08520
uniprot id: C7M7P2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

521097:COCH RS06435
gene id: 521097:COCH_RS06435
uniprot id: C7M5C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

521097:COCH RS01225
gene id: 521097:COCH_RS01225
uniprot id: C7M5J3
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

521097:COCH RS08825
gene id: 521097:COCH_RS08825
uniprot id: C7M840
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

521097:COCH RS10975
gene id: 521097:COCH_RS10975
uniprot id: C7M3T9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

521097:COCH RS01380
gene id: 521097:COCH_RS01380
uniprot id: C7M5M4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS07690
gene id: 521097:COCH_RS07690
uniprot id: C7M6U8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

521097:COCH RS02480
gene id: 521097:COCH_RS02480
uniprot id: C7M6R0
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09015
gene id: 521097:COCH_RS09015
uniprot id: C7M878
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

521097:COCH RS09570
gene id: 521097:COCH_RS09570
uniprot id: C7M8Q8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS10240
gene id: 521097:COCH_RS10240
uniprot id: C7M9I4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS09055
gene id: 521097:COCH_RS09055
uniprot id: C7M885
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

521097:COCH RS08640
gene id: 521097:COCH_RS08640
uniprot id: C7M7R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

521097:COCH RS05830
gene id: 521097:COCH_RS05830
uniprot id: C7M4S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

521097:COCH RS10865
gene id: 521097:COCH_RS10865
uniprot id: C7M3R7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

521097:COCH RS06805
gene id: 521097:COCH_RS06805
uniprot id: C7M5U5
names: Similarity
messages: Belongs to the Skp family.

521097:COCH RS00330
gene id: 521097:COCH_RS00330
uniprot id: C7M4J7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

521097:COCH RS04775
gene id: 521097:COCH_RS04775
uniprot id: C7M3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

521097:COCH RS03000
gene id: 521097:COCH_RS03000
uniprot id: C7M7J1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

521097:COCH RS05820
gene id: 521097:COCH_RS05820
uniprot id: C7M4S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

521097:COCH RS05870
gene id: 521097:COCH_RS05870
uniprot id: C7M4T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

521097:COCH RS02105
gene id: 521097:COCH_RS02105
uniprot id: C7M6J2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS07550
gene id: 521097:COCH_RS07550
uniprot id: C7M6S4
names: Similarity
messages: Belongs to the SUI1 family.

521097:COCH RS04975
gene id: 521097:COCH_RS04975
uniprot id: C7M3W0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

521097:COCH RS07035
gene id: 521097:COCH_RS07035
uniprot id: C7M685
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

521097:COCH RS06795
gene id: 521097:COCH_RS06795
uniprot id: C7M5U3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

521097:COCH RS10885
gene id: 521097:COCH_RS10885
uniprot id: C7M3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

521097:COCH RS07140
gene id: 521097:COCH_RS07140
uniprot id: C7M6A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

521097:COCH RS07345
gene id: 521097:COCH_RS07345
uniprot id: C7M6E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

521097:COCH RS02525
gene id: 521097:COCH_RS02525
uniprot id: C7M703
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10105
gene id: 521097:COCH_RS10105
uniprot id: C7M9F6
names: Similarity
messages: Belongs to the peptidase M13 family.

521097:COCH RS07880
gene id: 521097:COCH_RS07880
uniprot id: C7M6Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell inner membrane

521097:COCH RS10905
gene id: 521097:COCH_RS10905
uniprot id: C7M3S5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

521097:COCH RS09545
gene id: 521097:COCH_RS09545
uniprot id: C7M8Q6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

521097:COCH RS00465
gene id: 521097:COCH_RS00465
uniprot id: C7M4M5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521097:COCH RS01745
gene id: 521097:COCH_RS01745
uniprot id: C7M632
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

521097:COCH RS00445
gene id: 521097:COCH_RS00445
uniprot id: C7M4M1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10795
gene id: 521097:COCH_RS10795
uniprot id: C7M3Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

521097:COCH RS07610
gene id: 521097:COCH_RS07610
uniprot id: C7M6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

521097:COCH RS02880
gene id: 521097:COCH_RS02880
uniprot id: C7M7G9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

521097:COCH RS09800
gene id: 521097:COCH_RS09800
uniprot id: C7M8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

521097:COCH RS08765
gene id: 521097:COCH_RS08765
uniprot id: C7M827
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521097:COCH RS02030
gene id: 521097:COCH_RS02030
uniprot id: C7M6H7
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

521097:COCH RS02355
gene id: 521097:COCH_RS02355
uniprot id: C7M6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

521097:COCH RS10195
gene id: 521097:COCH_RS10195
uniprot id: C7M9H5
names: Similarity
messages: Belongs to the sulfatase family.

521097:COCH RS08910
gene id: 521097:COCH_RS08910
uniprot id: C7M857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

521097:COCH RS05180
gene id: 521097:COCH_RS05180
uniprot id: C7M400
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

521097:COCH RS07420
gene id: 521097:COCH_RS07420
uniprot id: C7M6G0
names: Similarity
messages: Belongs to the EPSP synthase family.

521097:COCH RS11035
gene id: 521097:COCH_RS11035
uniprot id: C7M4F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS09080
gene id: 521097:COCH_RS09080
uniprot id: C7M890
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05665
gene id: 521097:COCH_RS05665
uniprot id: C7M4C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS05740
gene id: 521097:COCH_RS05740
uniprot id: C7M4E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

521097:COCH RS08355
gene id: 521097:COCH_RS08355
uniprot id: C7M7C2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

521097:COCH RS00355
gene id: 521097:COCH_RS00355
uniprot id: C7M4K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

521097:COCH RS08645
gene id: 521097:COCH_RS08645
uniprot id: C7M7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

521097:COCH RS09815
gene id: 521097:COCH_RS09815
uniprot id: C7M8V7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

521097:COCH RS04045
gene id: 521097:COCH_RS04045
uniprot id: C7M911
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

521097:COCH RS09115
gene id: 521097:COCH_RS09115
uniprot id: C7M8H8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

521097:COCH RS09090
gene id: 521097:COCH_RS09090
uniprot id: C7M892
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

521097:COCH RS09290
gene id: 521097:COCH_RS09290
uniprot id: C7M8L3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

521097:COCH RS04625
gene id: 521097:COCH_RS04625
uniprot id: C7M9C8
names: Similarity
messages: Belongs to the GARS family.

521097:COCH RS03660
gene id: 521097:COCH_RS03660
uniprot id: C7M8B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

521097:COCH RS02035
gene id: 521097:COCH_RS02035
uniprot id: C7M6H8
names: Similarity
messages: Belongs to the sigma-54 factor family.

521097:COCH RS06445
gene id: 521097:COCH_RS06445
uniprot id: C7M5C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

521097:COCH RS03605
gene id: 521097:COCH_RS03605
uniprot id: C7M8A1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

521097:COCH RS09740
gene id: 521097:COCH_RS09740
uniprot id: C7M8U2
names: Similarity
messages: Belongs to the YciI family.

521097:COCH RS03980
gene id: 521097:COCH_RS03980
uniprot id: C7M8H3
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00135
gene id: 521097:COCH_RS00135
uniprot id: C7M4G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

521097:COCH RS10620
gene id: 521097:COCH_RS10620
uniprot id: C7M3L7
names: Similarity
messages: Belongs to the ClpA/ClpB family.

521097:COCH RS07770
gene id: 521097:COCH_RS07770
uniprot id: C7M6W1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

521097:COCH RS06765
gene id: 521097:COCH_RS06765
uniprot id: C7M5T7
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

521097:COCH RS06870
gene id: 521097:COCH_RS06870
uniprot id: C7M5V9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05540
gene id: 521097:COCH_RS05540
uniprot id: C7M4A2
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00540
gene id: 521097:COCH_RS00540
uniprot id: C7M4P0
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS10230
gene id: 521097:COCH_RS10230
uniprot id: C7M9I2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS08460
gene id: 521097:COCH_RS08460
uniprot id: C7M7M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS01705
gene id: 521097:COCH_RS01705
uniprot id: C7M624
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

521097:COCH RS02515
gene id: 521097:COCH_RS02515
uniprot id: C7M701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

521097:COCH RS01260
gene id: 521097:COCH_RS01260
uniprot id: C7M5K0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.

521097:COCH RS07830
gene id: 521097:COCH_RS07830
uniprot id: C7M6X3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

521097:COCH RS10415
gene id: 521097:COCH_RS10415
uniprot id: C7M3H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

521097:COCH RS10480
gene id: 521097:COCH_RS10480
uniprot id: C7M3I8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

521097:COCH RS10890
gene id: 521097:COCH_RS10890
uniprot id: C7M3S3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

521097:COCH RS07785
gene id: 521097:COCH_RS07785
uniprot id: C7M6W4
names: Similarity
messages: Belongs to the peptidase S41A family.

521097:COCH RS00970
gene id: 521097:COCH_RS00970
uniprot id: C7M554
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

521097:COCH RS10955
gene id: 521097:COCH_RS10955
uniprot id: C7M3T5
names: Similarity
messages: Belongs to the YicC/YloC family.

521097:COCH RS07525
gene id: 521097:COCH_RS07525
uniprot id: C7M6R9
names: Similarity
messages: Belongs to the fabD family.

521097:COCH RS11015
gene id: 521097:COCH_RS11015
uniprot id: C7M4E6
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS01345
gene id: 521097:COCH_RS01345
uniprot id: C7M5L6
names: Similarity
messages: Belongs to the asparaginase 1 family.

521097:COCH RS02190
gene id: 521097:COCH_RS02190
uniprot id: C7M6K8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

521097:COCH RS05535
gene id: 521097:COCH_RS05535
uniprot id: C7M4A1
names: Similarity
messages: Belongs to the cytochrome c-552 family.

521097:COCH RS10050
gene id: 521097:COCH_RS10050
uniprot id: C7M900
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00990
gene id: 521097:COCH_RS00990
uniprot id: C7M558
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

521097:COCH RS01920
gene id: 521097:COCH_RS01920
uniprot id: C7M666
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02020
gene id: 521097:COCH_RS02020
uniprot id: C7M6H5
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS10710
gene id: 521097:COCH_RS10710
uniprot id: C7M3N5
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

521097:COCH RS06685
gene id: 521097:COCH_RS06685
uniprot id: C7M5S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

521097:COCH RS01925
gene id: 521097:COCH_RS01925
uniprot id: C7M667
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

521097:COCH RS02125
gene id: 521097:COCH_RS02125
uniprot id: C7M6J6
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

521097:COCH RS06835
gene id: 521097:COCH_RS06835
uniprot id: C7M5V2
names: Similarity
messages: Belongs to the peptidase M1 family.

521097:COCH RS00655
gene id: 521097:COCH_RS00655
uniprot id: C7M4Z4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

521097:COCH RS10340
gene id: 521097:COCH_RS10340
uniprot id: C7M9K3
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

521097:COCH RS06645
gene id: 521097:COCH_RS06645
uniprot id: C7M5R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

521097:COCH RS09890
gene id: 521097:COCH_RS09890
uniprot id: C7M8X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

521097:COCH RS08230
gene id: 521097:COCH_RS08230
uniprot id: C7M797
names: Similarity
messages: Belongs to the IMPACT family.

521097:COCH RS10270
gene id: 521097:COCH_RS10270
uniprot id: C7M9J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

521097:COCH RS04205
gene id: 521097:COCH_RS04205
uniprot id: C7M944
names: Similarity
messages: Belongs to the Skp family.

521097:COCH RS08100
gene id: 521097:COCH_RS08100
uniprot id: C7M771
names: Similarity
messages: Belongs to the asparaginase 1 family.

521097:COCH RS01040
gene id: 521097:COCH_RS01040
uniprot id: C7M567
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

521097:COCH RS08140
gene id: 521097:COCH_RS08140
uniprot id: C7M779
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS09870
gene id: 521097:COCH_RS09870
uniprot id: C7M8W7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS03385
gene id: 521097:COCH_RS03385
uniprot id: C7M7X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10310
gene id: 521097:COCH_RS10310
uniprot id: C7M9J7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

521097:COCH RS03930
gene id: 521097:COCH_RS03930
uniprot id: C7M8G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS03730
gene id: 521097:COCH_RS03730
uniprot id: C7M8C5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

521097:COCH RS01030
gene id: 521097:COCH_RS01030
uniprot id: C7M565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

521097:COCH RS08410
gene id: 521097:COCH_RS08410
uniprot id: C7M7D3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

521097:COCH RS05005
gene id: 521097:COCH_RS05005
uniprot id: C7M3W5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

521097:COCH RS09275
gene id: 521097:COCH_RS09275
uniprot id: C7M8L0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

521097:COCH RS02215
gene id: 521097:COCH_RS02215
uniprot id: C7M6L3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

521097:COCH RS06260
gene id: 521097:COCH_RS06260
uniprot id: C7M591
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

521097:COCH RS01865
gene id: 521097:COCH_RS01865
uniprot id: C7M656
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

521097:COCH RS07135
gene id: 521097:COCH_RS07135
uniprot id: C7M6A6
names: Cofactor
messages: Binds 4 heme c groups covalently per monomer.

521097:COCH RS02570
gene id: 521097:COCH_RS02570
uniprot id: C7M712
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10565
gene id: 521097:COCH_RS10565
uniprot id: C7M3K5
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

521097:COCH RS05145
gene id: 521097:COCH_RS05145
uniprot id: C7M3Z3
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00945
gene id: 521097:COCH_RS00945
uniprot id: C7M549
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS08955
gene id: 521097:COCH_RS08955
uniprot id: C7M866
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

521097:COCH RS00140
gene id: 521097:COCH_RS00140
uniprot id: C7M4G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

521097:COCH RS04565
gene id: 521097:COCH_RS04565
uniprot id: C7M9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

521097:COCH RS01565
gene id: 521097:COCH_RS01565
uniprot id: C7M5Z6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

521097:COCH RS01680
gene id: 521097:COCH_RS01680
uniprot id: C7M619
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

521097:COCH RS07045
gene id: 521097:COCH_RS07045
uniprot id: C7M687
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS09515
gene id: 521097:COCH_RS09515
uniprot id: C7M8Q2
names: Similarity
messages: Belongs to the CarB family.

521097:COCH RS08330
gene id: 521097:COCH_RS08330
uniprot id: C7M7B7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS01365
gene id: 521097:COCH_RS01365
uniprot id: C7M5M1
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS08155
gene id: 521097:COCH_RS08155
uniprot id: C7M782
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS10970
gene id: 521097:COCH_RS10970
uniprot id: C7M3T8
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

521097:COCH RS03335
gene id: 521097:COCH_RS03335
uniprot id: C7M7W1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS06990
gene id: 521097:COCH_RS06990
uniprot id: C7M5Y3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

521097:COCH RS03370
gene id: 521097:COCH_RS03370
uniprot id: C7M7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS09985
gene id: 521097:COCH_RS09985
uniprot id: C7M8Z0
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

521097:COCH RS10880
gene id: 521097:COCH_RS10880
uniprot id: C7M3S0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

521097:COCH RS08810
gene id: 521097:COCH_RS08810
uniprot id: C7M837
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

521097:COCH RS08680
gene id: 521097:COCH_RS08680
uniprot id: C7M7S6
names: Similarity
messages: Belongs to the UPF0173 family.

521097:COCH RS05880
gene id: 521097:COCH_RS05880
uniprot id: C7M4T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

521097:COCH RS08635
gene id: 521097:COCH_RS08635
uniprot id: C7M7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

521097:COCH RS03485
gene id: 521097:COCH_RS03485
uniprot id: C7M7Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

521097:COCH RS01695
gene id: 521097:COCH_RS01695
uniprot id: C7M622
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

521097:COCH RS02045
gene id: 521097:COCH_RS02045
uniprot id: C7M6I0
names: Similarity
messages: Belongs to the LOG family.

521097:COCH RS02805
gene id: 521097:COCH_RS02805
uniprot id: C7M7F4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

521097:COCH RS01155
gene id: 521097:COCH_RS01155
uniprot id: C7M5H9
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS05410
gene id: 521097:COCH_RS05410
uniprot id: C7M476
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

521097:COCH RS06945
gene id: 521097:COCH_RS06945
uniprot id: C7M5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS04870
gene id: 521097:COCH_RS04870
uniprot id: C7M411
names: Similarity
messages: Belongs to the citrate synthase family.

521097:COCH RS02140
gene id: 521097:COCH_RS02140
uniprot id: C7M6J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

521097:COCH RS03570
gene id: 521097:COCH_RS03570
uniprot id: C7M808
names: Similarity
messages: Belongs to the YoeB family.

521097:COCH RS00305
gene id: 521097:COCH_RS00305
uniprot id: C7M4J2
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

521097:COCH RS08510
gene id: 521097:COCH_RS08510
uniprot id: C7M7P0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

521097:COCH RS08575
gene id: 521097:COCH_RS08575
uniprot id: C7M7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

521097:COCH RS10910
gene id: 521097:COCH_RS10910
uniprot id: C7M3S6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00920
gene id: 521097:COCH_RS00920
uniprot id: C7M547
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

521097:COCH RS01970
gene id: 521097:COCH_RS01970
uniprot id: C7M676
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS03555
gene id: 521097:COCH_RS03555
uniprot id: C7M805
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS03740
gene id: 521097:COCH_RS03740
uniprot id: C7M8C6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

521097:COCH RS10300
gene id: 521097:COCH_RS10300
uniprot id: C7M9J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

521097:COCH RS05240
gene id: 521097:COCH_RS05240
uniprot id: C7M417
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS01145
gene id: 521097:COCH_RS01145
uniprot id: C7M5H7
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

521097:COCH RS01690
gene id: 521097:COCH_RS01690
uniprot id: C7M621
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS03600
gene id: 521097:COCH_RS03600
uniprot id: C7M8A0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

521097:COCH RS08515
gene id: 521097:COCH_RS08515
uniprot id: C7M7P1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS08190
gene id: 521097:COCH_RS08190
uniprot id: C7M789
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS00715
gene id: 521097:COCH_RS00715
uniprot id: C7M507
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

521097:COCH RS07445
gene id: 521097:COCH_RS07445
uniprot id: C7M6G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

521097:COCH RS04150
gene id: 521097:COCH_RS04150
uniprot id: C7M932
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

521097:COCH RS03070
gene id: 521097:COCH_RS03070
uniprot id: C7M7K6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

521097:COCH RS10760
gene id: 521097:COCH_RS10760
uniprot id: C7M3P5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

521097:COCH RS02585
gene id: 521097:COCH_RS02585
uniprot id: C7M715
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS01940
gene id: 521097:COCH_RS01940
uniprot id: C7M670
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

521097:COCH RS06635
gene id: 521097:COCH_RS06635
uniprot id: C7M5R0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS06175
gene id: 521097:COCH_RS06175
uniprot id: C7M576
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

521097:COCH RS02245
gene id: 521097:COCH_RS02245
uniprot id: C7M6L9
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS02295
gene id: 521097:COCH_RS02295
uniprot id: C7M6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

521097:COCH RS03830
gene id: 521097:COCH_RS03830
uniprot id: C7M8E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

521097:COCH RS07700
gene id: 521097:COCH_RS07700
uniprot id: C7M6V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

521097:COCH RS01525
gene id: 521097:COCH_RS01525
uniprot id: C7M5Q4
names: Similarity
messages: Belongs to the thioredoxin family.

521097:COCH RS10080
gene id: 521097:COCH_RS10080
uniprot id: C7M9F1
names: Similarity
messages: Belongs to the CapA family.

521097:COCH RS07365
gene id: 521097:COCH_RS07365
uniprot id: C7M6E9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

521097:COCH RS01945
gene id: 521097:COCH_RS01945
uniprot id: C7M671
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

521097:COCH RS06170
gene id: 521097:COCH_RS06170
uniprot id: C7M575
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS05810
gene id: 521097:COCH_RS05810
uniprot id: C7M4S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

521097:COCH RS09895
gene id: 521097:COCH_RS09895
uniprot id: C7M8X2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS09840
gene id: 521097:COCH_RS09840
uniprot id: C7M8W2
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS06615
gene id: 521097:COCH_RS06615
uniprot id: C7M5G2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

521097:COCH RS02015
gene id: 521097:COCH_RS02015
uniprot id: C7M6H4
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

521097:COCH RS05670
gene id: 521097:COCH_RS05670
uniprot id: C7M4C8
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS00740
gene id: 521097:COCH_RS00740
uniprot id: C7M512
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

521097:COCH RS07855
gene id: 521097:COCH_RS07855
uniprot id: C7M6X8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

521097:COCH RS04590
gene id: 521097:COCH_RS04590
uniprot id: C7M9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

521097:COCH RS09235
gene id: 521097:COCH_RS09235
uniprot id: C7M8K2
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS01430
gene id: 521097:COCH_RS01430
uniprot id: C7M5N6
names: Similarity
messages: Belongs to the aspartokinase family.

521097:COCH RS05780
gene id: 521097:COCH_RS05780
uniprot id: C7M4R4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

521097:COCH RS06865
gene id: 521097:COCH_RS06865
uniprot id: C7M5V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

521097:COCH RS02240
gene id: 521097:COCH_RS02240
uniprot id: C7M6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS02820
gene id: 521097:COCH_RS02820
uniprot id: C7M7F7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521097:COCH RS09805
gene id: 521097:COCH_RS09805
uniprot id: C7M8V5
names: Similarity
messages: Belongs to the AlaDH/PNT family.

521097:COCH RS00070
gene id: 521097:COCH_RS00070
uniprot id: C7M447
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05245
gene id: 521097:COCH_RS05245
uniprot id: C7M418
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS02640
gene id: 521097:COCH_RS02640
uniprot id: C7M724
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

521097:COCH RS05590
gene id: 521097:COCH_RS05590
uniprot id: C7M4B2
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

521097:COCH RS06735
gene id: 521097:COCH_RS06735
uniprot id: C7M5T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

521097:COCH RS10625
gene id: 521097:COCH_RS10625
uniprot id: C7M3L8
names: Similarity
messages: Belongs to the peptidase C40 family.

521097:COCH RS00580
gene id: 521097:COCH_RS00580
uniprot id: C7M4P8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09440
gene id: 521097:COCH_RS09440
uniprot id: C7M8N9
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

521097:COCH RS04180
gene id: 521097:COCH_RS04180
uniprot id: C7M939
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

521097:COCH RS04010
gene id: 521097:COCH_RS04010
uniprot id: C7M903
names: Similarity
messages: Belongs to the LacAB/RpiB family.

521097:COCH RS06230
gene id: 521097:COCH_RS06230
uniprot id: C7M585
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

521097:COCH RS02520
gene id: 521097:COCH_RS02520
uniprot id: C7M702
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05635
gene id: 521097:COCH_RS05635
uniprot id: C7M4C1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS07005
gene id: 521097:COCH_RS07005
uniprot id: C7M5Y6
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09875
gene id: 521097:COCH_RS09875
uniprot id: C7M8W8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

521097:COCH RS07465
gene id: 521097:COCH_RS07465
uniprot id: C7M6G8
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00570
gene id: 521097:COCH_RS00570
uniprot id: C7M4P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

521097:COCH RS00065
gene id: 521097:COCH_RS00065
uniprot id: C7M446
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521097:COCH RS00665
gene id: 521097:COCH_RS00665
uniprot id: C7M4Z6
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07100
gene id: 521097:COCH_RS07100
uniprot id: C7M699
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

521097:COCH RS00040
gene id: 521097:COCH_RS00040
uniprot id: C7M441
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

521097:COCH RS05815
gene id: 521097:COCH_RS05815
uniprot id: C7M4S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

521097:COCH RS03390
gene id: 521097:COCH_RS03390
uniprot id: C7M7X2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

521097:COCH RS08670
gene id: 521097:COCH_RS08670
uniprot id: C7M7S4
names: Similarity
messages: Belongs to the RutC family.

521097:COCH RS06490
gene id: 521097:COCH_RS06490
uniprot id: C7M5D7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02150
gene id: 521097:COCH_RS02150
uniprot id: C7M6K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

521097:COCH RS09060
gene id: 521097:COCH_RS09060
uniprot id: C7M886
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

521097:COCH RS00520
gene id: 521097:COCH_RS00520
uniprot id: C7M4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS02365
gene id: 521097:COCH_RS02365
uniprot id: C7M6P2
names: Similarity
messages: Belongs to the DEAD box helicase family.

521097:COCH RS09735
gene id: 521097:COCH_RS09735
uniprot id: C7M8U1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521097:COCH RS05260
gene id: 521097:COCH_RS05260
uniprot id: C7M421
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

521097:COCH RS07835
gene id: 521097:COCH_RS07835
uniprot id: C7M6X4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS10960
gene id: 521097:COCH_RS10960
uniprot id: C7M3T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

521097:COCH RS07285
gene id: 521097:COCH_RS07285
uniprot id: C7M6D1
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

521097:COCH RS03580
gene id: 521097:COCH_RS03580
uniprot id: C7M810
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521097:COCH RS00125
gene id: 521097:COCH_RS00125
uniprot id: C7M4G0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

521097:COCH RS00800
gene id: 521097:COCH_RS00800
uniprot id: C7M525
names: Subcellular Location Annotation
messages: Secreted

521097:COCH RS03880
gene id: 521097:COCH_RS03880
uniprot id: C7M8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS08705
gene id: 521097:COCH_RS08705
uniprot id: C7M815
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

521097:COCH RS07710
gene id: 521097:COCH_RS07710
uniprot id: C7M6V3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521097:COCH RS02250
gene id: 521097:COCH_RS02250
uniprot id: C7M6M0
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

521097:COCH RS10595
gene id: 521097:COCH_RS10595
uniprot id: C7M3L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

521097:COCH RS03320
gene id: 521097:COCH_RS03320
uniprot id: C7M7V8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

521097:COCH RS10460
gene id: 521097:COCH_RS10460
uniprot id: C7M3I4
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

521097:COCH RS01050
gene id: 521097:COCH_RS01050
uniprot id: C7M569
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

521097:COCH RS03975
gene id: 521097:COCH_RS03975
uniprot id: C7M8H2
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS09165
gene id: 521097:COCH_RS09165
uniprot id: C7M8I8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

521097:COCH RS00660
gene id: 521097:COCH_RS00660
uniprot id: C7M4Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

521097:COCH RS02075
gene id: 521097:COCH_RS02075
uniprot id: C7M6I6
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

521097:COCH RS00545
gene id: 521097:COCH_RS00545
uniprot id: C7M4P1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

521097:COCH RS01140
gene id: 521097:COCH_RS01140
uniprot id: C7M5H6
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

521097:COCH RS02550
gene id: 521097:COCH_RS02550
uniprot id: C7M708
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

521097:COCH RS07620
gene id: 521097:COCH_RS07620
uniprot id: C7M6T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

521097:COCH RS10290
gene id: 521097:COCH_RS10290
uniprot id: C7M9J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

521097:COCH RS00510
gene id: 521097:COCH_RS00510
uniprot id: C7M4N4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

521097:COCH RS08165
gene id: 521097:COCH_RS08165
uniprot id: C7M784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

521097:COCH RS02435
gene id: 521097:COCH_RS02435
uniprot id: C7M6Q1
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS00725
gene id: 521097:COCH_RS00725
uniprot id: C7M509
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

521097:COCH RS04130
gene id: 521097:COCH_RS04130
uniprot id: C7M928
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

521097:COCH RS11010
gene id: 521097:COCH_RS11010
uniprot id: C7M4E5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

521097:COCH RS04680
gene id: 521097:COCH_RS04680
uniprot id: C7M9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS08685
gene id: 521097:COCH_RS08685
uniprot id: C7M811
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

521097:COCH RS11050
gene id: 521097:COCH_RS11050
uniprot id: C7M4F3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

521097:COCH RS05855
gene id: 521097:COCH_RS05855
uniprot id: C7M4S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521097:COCH RS00215
gene id: 521097:COCH_RS00215
uniprot id: C7M4H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

521097:COCH RS03670
gene id: 521097:COCH_RS03670
uniprot id: C7M8B3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

521097:COCH RS07125
gene id: 521097:COCH_RS07125
uniprot id: C7M6A4
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

521097:COCH RS05350
gene id: 521097:COCH_RS05350
uniprot id: C7M463
names: Similarity
messages: Belongs to the pyruvate kinase family.

521097:COCH RS10025
gene id: 521097:COCH_RS10025
uniprot id: C7M8Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

521097:COCH RS00535
gene id: 521097:COCH_RS00535
uniprot id: C7M4N9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

521097:COCH RS08195
gene id: 521097:COCH_RS08195
uniprot id: C7M790
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

521097:COCH RS10670
gene id: 521097:COCH_RS10670
uniprot id: C7M3M7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

521097:COCH RS04710
gene id: 521097:COCH_RS04710
uniprot id: C7M3E6
names: Similarity
messages: Belongs to the SufE family.

521097:COCH RS07800
gene id: 521097:COCH_RS07800
uniprot id: C7M6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS00320
gene id: 521097:COCH_RS00320
uniprot id: C7M4J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

521097:COCH RS10820
gene id: 521097:COCH_RS10820
uniprot id: C7M3Q7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

521097:COCH RS02470
gene id: 521097:COCH_RS02470
uniprot id: C7M6Q8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

521097:COCH RS09750
gene id: 521097:COCH_RS09750
uniprot id: C7M8U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

521097:COCH RS05130
gene id: 521097:COCH_RS05130
uniprot id: C7M3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

521097:COCH RS09630
gene id: 521097:COCH_RS09630
uniprot id: C7M8S0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS07340
gene id: 521097:COCH_RS07340
uniprot id: C7M6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

521097:COCH RS01590
gene id: 521097:COCH_RS01590
uniprot id: C7M601
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

521097:COCH RS06160
gene id: 521097:COCH_RS06160
uniprot id: C7M4Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

521097:COCH RS07455
gene id: 521097:COCH_RS07455
uniprot id: C7M6G6
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS03780
gene id: 521097:COCH_RS03780
uniprot id: C7M8D4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

521097:COCH RS03655
gene id: 521097:COCH_RS03655
uniprot id: C7M8B0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

521097:COCH RS05715
gene id: 521097:COCH_RS05715
uniprot id: C7M4D6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

521097:COCH RS09540
gene id: 521097:COCH_RS09540
uniprot id: C7M8Q5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

521097:COCH RS10295
gene id: 521097:COCH_RS10295
uniprot id: C7M9J4
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS09790
gene id: 521097:COCH_RS09790
uniprot id: C7M8V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

521097:COCH RS03855
gene id: 521097:COCH_RS03855
uniprot id: C7M8E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

521097:COCH RS08490
gene id: 521097:COCH_RS08490
uniprot id: C7M7N6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

521097:COCH RS04245
gene id: 521097:COCH_RS04245
uniprot id: C7M952
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

521097:COCH RS04580
gene id: 521097:COCH_RS04580
uniprot id: C7M9B9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

521097:COCH RS06665
gene id: 521097:COCH_RS06665
uniprot id: C7M5R6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS05210
gene id: 521097:COCH_RS05210
uniprot id: C7M405
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS07960
gene id: 521097:COCH_RS07960
uniprot id: C7M744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

521097:COCH RS11000
gene id: 521097:COCH_RS11000
uniprot id: C7M4E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

521097:COCH RS05455
gene id: 521097:COCH_RS05455
uniprot id: C7M485
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

521097:COCH RS05680
gene id: 521097:COCH_RS05680
uniprot id: C7M4D0
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

521097:COCH RS07055
gene id: 521097:COCH_RS07055
uniprot id: C7M689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

521097:COCH RS03010
gene id: 521097:COCH_RS03010
uniprot id: C7M7J3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

521097:COCH RS01540
gene id: 521097:COCH_RS01540
uniprot id: C7M5Z1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

521097:COCH RS02720
gene id: 521097:COCH_RS02720
uniprot id: C7M742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS10800
gene id: 521097:COCH_RS10800
uniprot id: C7M3Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

521097:COCH RS00200
gene id: 521097:COCH_RS00200
uniprot id: C7M4H2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

521097:COCH RS10360
gene id: 521097:COCH_RS10360
uniprot id: C7M9K7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS00530
gene id: 521097:COCH_RS00530
uniprot id: C7M4N8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

521097:COCH RS07385
gene id: 521097:COCH_RS07385
uniprot id: C7M6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS01200
gene id: 521097:COCH_RS01200
uniprot id: C7M5I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

521097:COCH RS09330
gene id: 521097:COCH_RS09330
uniprot id: C7M8M1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

521097:COCH RS03190
gene id: 521097:COCH_RS03190
uniprot id: C7M7T1
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS08570
gene id: 521097:COCH_RS08570
uniprot id: C7M7Q3
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07295
gene id: 521097:COCH_RS07295
uniprot id: C7M6D3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

521097:COCH RS05195
gene id: 521097:COCH_RS05195
uniprot id: C7M402
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

521097:COCH RS10950
gene id: 521097:COCH_RS10950
uniprot id: C7M3T4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

521097:COCH RS06885
gene id: 521097:COCH_RS06885
uniprot id: C7M5W2
names: Similarity
messages: Belongs to the ribF family.

521097:COCH RS02300
gene id: 521097:COCH_RS02300
uniprot id: C7M6N0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

521097:COCH RS09730
gene id: 521097:COCH_RS09730
uniprot id: C7M8U0
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02845
gene id: 521097:COCH_RS02845
uniprot id: C7M7G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

521097:COCH RS05640
gene id: 521097:COCH_RS05640
uniprot id: C7M4C2
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS00975
gene id: 521097:COCH_RS00975
uniprot id: C7M555
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

521097:COCH RS08150
gene id: 521097:COCH_RS08150
uniprot id: C7M781
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS01640
gene id: 521097:COCH_RS01640
uniprot id: C7M611
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

521097:COCH RS05480
gene id: 521097:COCH_RS05480
uniprot id: C7M489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

521097:COCH RS10355
gene id: 521097:COCH_RS10355
uniprot id: C7M9K6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521097:COCH RS01020
gene id: 521097:COCH_RS01020
uniprot id: C7M564
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

521097:COCH RS09120
gene id: 521097:COCH_RS09120
uniprot id: C7M8H9
names: Similarity
messages: Belongs to the peptidase C40 family.

521097:COCH RS04665
gene id: 521097:COCH_RS04665
uniprot id: C7M9D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 66 family.

521097:COCH RS05485
gene id: 521097:COCH_RS05485
uniprot id: C7M490
names: Similarity
messages: Belongs to the UPF0045 family.

521097:COCH RS10160
gene id: 521097:COCH_RS10160
uniprot id: C7M9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

521097:COCH RS02635
gene id: 521097:COCH_RS02635
uniprot id: C7M723
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS10410
gene id: 521097:COCH_RS10410
uniprot id: C7M9L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

521097:COCH RS10220
gene id: 521097:COCH_RS10220
uniprot id: C7M9I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

521097:COCH RS06000
gene id: 521097:COCH_RS06000
uniprot id: C7M4V8
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

521097:COCH RS05835
gene id: 521097:COCH_RS05835
uniprot id: C7M4S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

521097:COCH RS00325
gene id: 521097:COCH_RS00325
uniprot id: C7M4J6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

521097:COCH RS06220
gene id: 521097:COCH_RS06220
uniprot id: C7M583
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

521097:COCH RS09580
gene id: 521097:COCH_RS09580
uniprot id: C7M8R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

521097:COCH RS02135
gene id: 521097:COCH_RS02135
uniprot id: C7M6J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

521097:COCH RS00010
gene id: 521097:COCH_RS00010
uniprot id: C7M436
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

521097:COCH RS02715
gene id: 521097:COCH_RS02715
uniprot id: C7M741
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS07205
gene id: 521097:COCH_RS07205
uniprot id: C7M6C0
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

521097:COCH RS06815
gene id: 521097:COCH_RS06815
uniprot id: C7M5U7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

521097:COCH RS10320
gene id: 521097:COCH_RS10320
uniprot id: C7M9J9
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02950
gene id: 521097:COCH_RS02950
uniprot id: C7M7I0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

521097:COCH RS01400
gene id: 521097:COCH_RS01400
uniprot id: C7M5M9
names: Similarity
messages: Belongs to the DinB family.

521097:COCH RS05000
gene id: 521097:COCH_RS05000
uniprot id: C7M3W4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

521097:COCH RS06680
gene id: 521097:COCH_RS06680
uniprot id: C7M5R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

521097:COCH RS07470
gene id: 521097:COCH_RS07470
uniprot id: C7M6G9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS08065
gene id: 521097:COCH_RS08065
uniprot id: C7M765
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS06345
gene id: 521097:COCH_RS06345
uniprot id: C7M5A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

521097:COCH RS07475
gene id: 521097:COCH_RS07475
uniprot id: C7M6H0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

521097:COCH RS09915
gene id: 521097:COCH_RS09915
uniprot id: C7M8X7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS08615
gene id: 521097:COCH_RS08615
uniprot id: C7M7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

521097:COCH RS02090
gene id: 521097:COCH_RS02090
uniprot id: C7M6I9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

521097:COCH RS09245
gene id: 521097:COCH_RS09245
uniprot id: C7M8K4
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

521097:COCH RS02975
gene id: 521097:COCH_RS02975
uniprot id: C7M7I5
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

521097:COCH RS10810
gene id: 521097:COCH_RS10810
uniprot id: C7M3Q4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

521097:COCH RS08710
gene id: 521097:COCH_RS08710
uniprot id: C7M816
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

521097:COCH RS00785
gene id: 521097:COCH_RS00785
uniprot id: C7M522
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521097:COCH RS06450
gene id: 521097:COCH_RS06450
uniprot id: C7M5C9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS06780
gene id: 521097:COCH_RS06780
uniprot id: C7M5U0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521097:COCH RS10570
gene id: 521097:COCH_RS10570
uniprot id: C7M3K6
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

521097:COCH RS05400
gene id: 521097:COCH_RS05400
uniprot id: C7M474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

521097:COCH RS00155
gene id: 521097:COCH_RS00155
uniprot id: C7M4G6
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

521097:COCH RS07615
gene id: 521097:COCH_RS07615
uniprot id: C7M6T4
names: Similarity
messages: Belongs to the aldose epimerase family.

521097:COCH RS08525
gene id: 521097:COCH_RS08525
uniprot id: C7M7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

521097:COCH RS08950
gene id: 521097:COCH_RS08950
uniprot id: C7M865
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07120
gene id: 521097:COCH_RS07120
uniprot id: C7M6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

521097:COCH RS08075
gene id: 521097:COCH_RS08075
uniprot id: C7M766
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS08970
gene id: 521097:COCH_RS08970
uniprot id: C7M869
names: Similarity
messages: Belongs to the CapA family.

521097:COCH RS01370
gene id: 521097:COCH_RS01370
uniprot id: C7M5M2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

521097:COCH RS08185
gene id: 521097:COCH_RS08185
uniprot id: C7M788
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521097:COCH RS04830
gene id: 521097:COCH_RS04830
uniprot id: C7M3G9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

521097:COCH RS07565
gene id: 521097:COCH_RS07565
uniprot id: C7M6S7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

521097:COCH RS05135
gene id: 521097:COCH_RS05135
uniprot id: C7M3Z1
names: Similarity
messages: Belongs to the SusD family.

521097:COCH RS09710
gene id: 521097:COCH_RS09710
uniprot id: C7M8T6
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS05940
gene id: 521097:COCH_RS05940
uniprot id: C7M4U7
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS07210
gene id: 521097:COCH_RS07210
uniprot id: C7M6C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

521097:COCH RS10255
gene id: 521097:COCH_RS10255
uniprot id: C7M9I7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521097:COCH RS03770
gene id: 521097:COCH_RS03770
uniprot id: C7M8D2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

521097:COCH RS09910
gene id: 521097:COCH_RS09910
uniprot id: C7M8X6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

521097:COCH RS06470
gene id: 521097:COCH_RS06470
uniprot id: C7M5D3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

521097:COCH RS01860
gene id: 521097:COCH_RS01860
uniprot id: C7M655
names: Subcellular Location Annotation
messages: Membrane

521097:COCH RS02320
gene id: 521097:COCH_RS02320
uniprot id: C7M6N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.