521045:KOLE RS06020
gene id: 521045:KOLE_RS06020
uniprot id: C5CIK9
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

521045:KOLE RS00035
gene id: 521045:KOLE_RS00035
uniprot id: C5CH96
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

521045:KOLE RS05890
gene id: 521045:KOLE_RS05890
uniprot id: C5CIK6
names: Similarity
messages: Belongs to the peptidase S9A family.
messages: Belongs to the peptidase S9C family.

521045:KOLE RS08805
gene id: 521045:KOLE_RS08805
uniprot id: C5CFT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS08900
gene id: 521045:KOLE_RS08900
uniprot id: C5CFV0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

521045:KOLE RS01300
gene id: 521045:KOLE_RS01300
uniprot id: C5CD36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

521045:KOLE RS10675
gene id: 521045:KOLE_RS10675
uniprot id: C5CI87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS07290
gene id: 521045:KOLE_RS07290
uniprot id: C5CE39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

521045:KOLE RS10620
gene id: 521045:KOLE_RS10620
uniprot id: C5CI76
names: Similarity
messages: Belongs to the ribF family.

521045:KOLE RS10830
gene id: 521045:KOLE_RS10830
uniprot id: C5CIN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

521045:KOLE RS00420
gene id: 521045:KOLE_RS00420
uniprot id: C5CHV4
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS04905
gene id: 521045:KOLE_RS04905
uniprot id: C5CH15
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

521045:KOLE RS08700
gene id: 521045:KOLE_RS08700
uniprot id: C5CFQ9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08630
gene id: 521045:KOLE_RS08630
uniprot id: C5CFP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

521045:KOLE RS07900
gene id: 521045:KOLE_RS07900
uniprot id: C5CES7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

521045:KOLE RS01780
gene id: 521045:KOLE_RS01780
uniprot id: C5CDI7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

521045:KOLE RS01305
gene id: 521045:KOLE_RS01305
uniprot id: C5CD37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

521045:KOLE RS03980
gene id: 521045:KOLE_RS03980
uniprot id: C5CG59
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09335
gene id: 521045:KOLE_RS09335
uniprot id: C5CGE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

521045:KOLE RS10835
gene id: 521045:KOLE_RS10835
uniprot id: C5CIN8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

521045:KOLE RS01375
gene id: 521045:KOLE_RS01375
uniprot id: C5CD51
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

521045:KOLE RS00895
gene id: 521045:KOLE_RS00895
uniprot id: C5CIG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS10645
gene id: 521045:KOLE_RS10645
uniprot id: C5CI81
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10625
gene id: 521045:KOLE_RS10625
uniprot id: C5CI77
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

521045:KOLE RS05000
gene id: 521045:KOLE_RS05000
uniprot id: C5CH34
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

521045:KOLE RS10045
gene id: 521045:KOLE_RS10045
uniprot id: C5CH65
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

521045:KOLE RS10100
gene id: 521045:KOLE_RS10100
uniprot id: C5CH76
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

521045:KOLE RS02675
gene id: 521045:KOLE_RS02675
uniprot id: C5CEK1
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS03050
gene id: 521045:KOLE_RS03050
uniprot id: C5CEY7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

521045:KOLE RS03555
gene id: 521045:KOLE_RS03555
uniprot id: C5CFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

521045:KOLE RS09660
gene id: 521045:KOLE_RS09660
uniprot id: C5CGS4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

521045:KOLE RS04735
gene id: 521045:KOLE_RS04735
uniprot id: C5CGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS00110
gene id: 521045:KOLE_RS00110
uniprot id: C5CHB1
names: Similarity
messages: Belongs to the histone deacetylase family.

521045:KOLE RS06815
gene id: 521045:KOLE_RS06815
uniprot id: C5CDP3
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

521045:KOLE RS01035
gene id: 521045:KOLE_RS01035
uniprot id: C5CIT9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

521045:KOLE RS08205
gene id: 521045:KOLE_RS08205
uniprot id: C5CF51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

521045:KOLE RS10070
gene id: 521045:KOLE_RS10070
uniprot id: C5CH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS04765
gene id: 521045:KOLE_RS04765
uniprot id: C5CGY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

521045:KOLE RS09800
gene id: 521045:KOLE_RS09800
uniprot id: C5CGV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

521045:KOLE RS03640
gene id: 521045:KOLE_RS03640
uniprot id: C5CFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

521045:KOLE RS01055
gene id: 521045:KOLE_RS01055
uniprot id: C5CIU3
names: Similarity
messages: Belongs to the YggT family.

521045:KOLE RS01575
gene id: 521045:KOLE_RS01575
uniprot id: C5CD91
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09310
gene id: 521045:KOLE_RS09310
uniprot id: C5CGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

521045:KOLE RS09680
gene id: 521045:KOLE_RS09680
uniprot id: C5CGS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

521045:KOLE RS07065
gene id: 521045:KOLE_RS07065
uniprot id: C5CE00
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS01820
gene id: 521045:KOLE_RS01820
uniprot id: C5CDJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

521045:KOLE RS04305
gene id: 521045:KOLE_RS04305
uniprot id: C5CGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

521045:KOLE RS09000
gene id: 521045:KOLE_RS09000
uniprot id: C5CFX0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07965
gene id: 521045:KOLE_RS07965
uniprot id: C5CF01
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

521045:KOLE RS01330
gene id: 521045:KOLE_RS01330
uniprot id: C5CD42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

521045:KOLE RS11085
gene id: 521045:KOLE_RS11085
uniprot id: C5CG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS06850
gene id: 521045:KOLE_RS06850
uniprot id: C5CDQ1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

521045:KOLE RS06210
gene id: 521045:KOLE_RS06210
uniprot id: C5CJ12
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

521045:KOLE RS05960
gene id: 521045:KOLE_RS05960
uniprot id: C5CIM1
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

521045:KOLE RS06580
gene id: 521045:KOLE_RS06580
uniprot id: C5CDD8
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

521045:KOLE RS04025
gene id: 521045:KOLE_RS04025
uniprot id: C5CG68
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00260
gene id: 521045:KOLE_RS00260
uniprot id: C5CHD7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521045:KOLE RS00175
gene id: 521045:KOLE_RS00175
uniprot id: C5CHC4
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

521045:KOLE RS07670
gene id: 521045:KOLE_RS07670
uniprot id: C5CEN2
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

521045:KOLE RS02770
gene id: 521045:KOLE_RS02770
uniprot id: C5CEL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

521045:KOLE RS01405
gene id: 521045:KOLE_RS01405
uniprot id: C5CD57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS07220
gene id: 521045:KOLE_RS07220
uniprot id: C5CE26
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

521045:KOLE RS01280
gene id: 521045:KOLE_RS01280
uniprot id: C5CD32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

521045:KOLE RS03405
gene id: 521045:KOLE_RS03405
uniprot id: C5CFB0
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

521045:KOLE RS10305
gene id: 521045:KOLE_RS10305
uniprot id: C5CHP2
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

521045:KOLE RS04295
gene id: 521045:KOLE_RS04295
uniprot id: C5CGC0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

521045:KOLE RS00145
gene id: 521045:KOLE_RS00145
uniprot id: C5CHB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

521045:KOLE RS10480
gene id: 521045:KOLE_RS10480
uniprot id: C5CHS6
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

521045:KOLE RS05565
gene id: 521045:KOLE_RS05565
uniprot id: C5CI27
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10420
gene id: 521045:KOLE_RS10420
uniprot id: C5CHR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS04690
gene id: 521045:KOLE_RS04690
uniprot id: C5CGX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

521045:KOLE RS02820
gene id: 521045:KOLE_RS02820
uniprot id: C5CEM7
names: Similarity
messages: Belongs to the peptidase U62 family.

521045:KOLE RS08770
gene id: 521045:KOLE_RS08770
uniprot id: C5CFS3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

521045:KOLE RS01450
gene id: 521045:KOLE_RS01450
uniprot id: C5CD66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

521045:KOLE RS02230
gene id: 521045:KOLE_RS02230
uniprot id: C5CE50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

521045:KOLE RS02460
gene id: 521045:KOLE_RS02460
uniprot id: C5CEA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS07755
gene id: 521045:KOLE_RS07755
uniprot id: C5CEP9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

521045:KOLE RS07210
gene id: 521045:KOLE_RS07210
uniprot id: C5CE24
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521045:KOLE RS08340
gene id: 521045:KOLE_RS08340
uniprot id: C5CFC9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

521045:KOLE RS01410
gene id: 521045:KOLE_RS01410
uniprot id: C5CD58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS05550
gene id: 521045:KOLE_RS05550
uniprot id: C5CI24
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07485
gene id: 521045:KOLE_RS07485
uniprot id: C5CED7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

521045:KOLE RS07360
gene id: 521045:KOLE_RS07360
uniprot id: C5CEB5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

521045:KOLE RS10310
gene id: 521045:KOLE_RS10310
uniprot id: C5CHP3
names: Similarity
messages: Belongs to the ClpA/ClpB family.

521045:KOLE RS01615
gene id: 521045:KOLE_RS01615
uniprot id: C5CDF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

521045:KOLE RS07595
gene id: 521045:KOLE_RS07595
uniprot id: C5CEF7
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS04745
gene id: 521045:KOLE_RS04745
uniprot id: C5CGY4
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

521045:KOLE RS02905
gene id: 521045:KOLE_RS02905
uniprot id: C5CEV3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

521045:KOLE RS09195
gene id: 521045:KOLE_RS09195
uniprot id: C5CG09
names: Similarity
messages: Belongs to the peptidase S9C family.

521045:KOLE RS10430
gene id: 521045:KOLE_RS10430
uniprot id: C5CHR6
names: Subcellular Location Annotation
messages: Cytoplasm

521045:KOLE RS10845
gene id: 521045:KOLE_RS10845
uniprot id: C5CIP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521045:KOLE RS04590
gene id: 521045:KOLE_RS04590
uniprot id: C5CGN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS01555
gene id: 521045:KOLE_RS01555
uniprot id: C5CD87
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

521045:KOLE RS01745
gene id: 521045:KOLE_RS01745
uniprot id: C5CDH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

521045:KOLE RS08560
gene id: 521045:KOLE_RS08560
uniprot id: C5CFH3
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

521045:KOLE RS09340
gene id: 521045:KOLE_RS09340
uniprot id: C5CGE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

521045:KOLE RS08910
gene id: 521045:KOLE_RS08910
uniprot id: C5CFV2
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10060
gene id: 521045:KOLE_RS10060
uniprot id: C5CH68
names: Similarity
messages: Belongs to the peptidase C40 family.

521045:KOLE RS04965
gene id: 521045:KOLE_RS04965
uniprot id: C5CH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS06935
gene id: 521045:KOLE_RS06935
uniprot id: C5CDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

521045:KOLE RS01795
gene id: 521045:KOLE_RS01795
uniprot id: C5CDJ0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

521045:KOLE RS08200
gene id: 521045:KOLE_RS08200
uniprot id: B5M6L6
names: Similarity
messages: Belongs to the pyruvate kinase family.

521045:KOLE RS03110
gene id: 521045:KOLE_RS03110
uniprot id: C5CEZ9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

521045:KOLE RS01275
gene id: 521045:KOLE_RS01275
uniprot id: C5CD31
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

521045:KOLE RS07510
gene id: 521045:KOLE_RS07510
uniprot id: C5CEE2
names: Subcellular Location Annotation
messages: Cytoplasm

521045:KOLE RS04605
gene id: 521045:KOLE_RS04605
uniprot id: C5CGP2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

521045:KOLE RS10725
gene id: 521045:KOLE_RS10725
uniprot id: C5CI97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

521045:KOLE RS09305
gene id: 521045:KOLE_RS09305
uniprot id: C5CGE4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

521045:KOLE RS08755
gene id: 521045:KOLE_RS08755
uniprot id: C5CFS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

521045:KOLE RS06855
gene id: 521045:KOLE_RS06855
uniprot id: C5CDQ2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

521045:KOLE RS08020
gene id: 521045:KOLE_RS08020
uniprot id: C5CF12
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

521045:KOLE RS05315
gene id: 521045:KOLE_RS05315
uniprot id: C5CHJ7
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS05155
gene id: 521045:KOLE_RS05155
uniprot id: C5CHH1
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS08985
gene id: 521045:KOLE_RS08985
uniprot id: C5CFW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS09510
gene id: 521045:KOLE_RS09510
uniprot id: C5CGI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

521045:KOLE RS01925
gene id: 521045:KOLE_RS01925
uniprot id: C5CDT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS07215
gene id: 521045:KOLE_RS07215
uniprot id: C5CE25
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

521045:KOLE RS02595
gene id: 521045:KOLE_RS02595
uniprot id: C5CEI6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

521045:KOLE RS04795
gene id: 521045:KOLE_RS04795
uniprot id: C5CGZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

521045:KOLE RS07330
gene id: 521045:KOLE_RS07330
uniprot id: C5CEA9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

521045:KOLE RS03825
gene id: 521045:KOLE_RS03825
uniprot id: C5CG24
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00475
gene id: 521045:KOLE_RS00475
uniprot id: C5CHW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

521045:KOLE RS07500
gene id: 521045:KOLE_RS07500
uniprot id: C5CEE0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

521045:KOLE RS07585
gene id: 521045:KOLE_RS07585
uniprot id: C5CE16
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS11710
gene id: 521045:KOLE_RS11710
uniprot id: C5CIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

521045:KOLE RS10890
gene id: 521045:KOLE_RS10890
uniprot id: C5CIP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

521045:KOLE RS09690
gene id: 521045:KOLE_RS09690
uniprot id: C5CGT0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521045:KOLE RS06700
gene id: 521045:KOLE_RS06700
uniprot id: C5CDL9
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

521045:KOLE RS06915
gene id: 521045:KOLE_RS06915
uniprot id: C5CDR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

521045:KOLE RS11005
gene id: 521045:KOLE_RS11005
uniprot id: C5CD28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

521045:KOLE RS06740
gene id: 521045:KOLE_RS06740
uniprot id: C5CDM7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

521045:KOLE RS02325
gene id: 521045:KOLE_RS02325
uniprot id: C5CE69
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

521045:KOLE RS04555
gene id: 521045:KOLE_RS04555
uniprot id: C5CGM9
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

521045:KOLE RS05940
gene id: 521045:KOLE_RS05940
uniprot id: C5CIL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS03035
gene id: 521045:KOLE_RS03035
uniprot id: C5CEY4
names: Similarity
messages: Belongs to the UPF0597 family.

521045:KOLE RS02570
gene id: 521045:KOLE_RS02570
uniprot id: C5CEI1
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

521045:KOLE RS02590
gene id: 521045:KOLE_RS02590
uniprot id: C5CEI5
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

521045:KOLE RS10685
gene id: 521045:KOLE_RS10685
uniprot id: C5CI89
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

521045:KOLE RS01050
gene id: 521045:KOLE_RS01050
uniprot id: C5CIU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS09475
gene id: 521045:KOLE_RS09475
uniprot id: C5CGH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

521045:KOLE RS09835
gene id: 521045:KOLE_RS09835
uniprot id: C5CGV9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01590
gene id: 521045:KOLE_RS01590
uniprot id: C5CD94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

521045:KOLE RS07295
gene id: 521045:KOLE_RS07295
uniprot id: C5CE40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

521045:KOLE RS07255
gene id: 521045:KOLE_RS07255
uniprot id: C5CE33
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

521045:KOLE RS00025
gene id: 521045:KOLE_RS00025
uniprot id: C5CH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

521045:KOLE RS01980
gene id: 521045:KOLE_RS01980
uniprot id: C5CDU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

521045:KOLE RS09790
gene id: 521045:KOLE_RS09790
uniprot id: C5CGV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

521045:KOLE RS10930
gene id: 521045:KOLE_RS10930
uniprot id: C5CIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

521045:KOLE RS01125
gene id: 521045:KOLE_RS01125
uniprot id: C5CIV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

521045:KOLE RS06905
gene id: 521045:KOLE_RS06905
uniprot id: C5CDR0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS04260
gene id: 521045:KOLE_RS04260
uniprot id: C5CGB3
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00205
gene id: 521045:KOLE_RS00205
uniprot id: C5CHD0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

521045:KOLE RS03455
gene id: 521045:KOLE_RS03455
uniprot id: C5CFH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS03065
gene id: 521045:KOLE_RS03065
uniprot id: C5CEZ0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

521045:KOLE RS09595
gene id: 521045:KOLE_RS09595
uniprot id: C5CGR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

521045:KOLE RS10710
gene id: 521045:KOLE_RS10710
uniprot id: C5CI94
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

521045:KOLE RS05995
gene id: 521045:KOLE_RS05995
uniprot id: C5CIM8
names: Similarity
messages: Belongs to the peptidase S9C family.

521045:KOLE RS04810
gene id: 521045:KOLE_RS04810
uniprot id: C5CGZ7
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01385
gene id: 521045:KOLE_RS01385
uniprot id: C5CD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

521045:KOLE RS09495
gene id: 521045:KOLE_RS09495
uniprot id: C5CGH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

521045:KOLE RS01630
gene id: 521045:KOLE_RS01630
uniprot id: C5CDG2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

521045:KOLE RS06990
gene id: 521045:KOLE_RS06990
uniprot id: C5CDY7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

521045:KOLE RS04790
gene id: 521045:KOLE_RS04790
uniprot id: C5CGZ3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

521045:KOLE RS03505
gene id: 521045:KOLE_RS03505
uniprot id: C5CFI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS08255
gene id: 521045:KOLE_RS08255
uniprot id: C5CFB8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521045:KOLE RS06355
gene id: 521045:KOLE_RS06355
uniprot id: C5CJ42
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

521045:KOLE RS08120
gene id: 521045:KOLE_RS08120
uniprot id: C5CF36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

521045:KOLE RS08380
gene id: 521045:KOLE_RS08380
uniprot id: C5CFD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

521045:KOLE RS00340
gene id: 521045:KOLE_RS00340
uniprot id: C5CHT5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

521045:KOLE RS07125
gene id: 521045:KOLE_RS07125
uniprot id: C5CE10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

521045:KOLE RS07870
gene id: 521045:KOLE_RS07870
uniprot id: C5CES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

521045:KOLE RS02985
gene id: 521045:KOLE_RS02985
uniprot id: C5CEX0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

521045:KOLE RS07705
gene id: 521045:KOLE_RS07705
uniprot id: C5CEN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

521045:KOLE RS05850
gene id: 521045:KOLE_RS05850
uniprot id: C5CIJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS00010
gene id: 521045:KOLE_RS00010
uniprot id: C5CH91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

521045:KOLE RS05245
gene id: 521045:KOLE_RS05245
uniprot id: C5CHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09085
gene id: 521045:KOLE_RS09085
uniprot id: C5CFY6
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS09300
gene id: 521045:KOLE_RS09300
uniprot id: C5CGE3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

521045:KOLE RS09430
gene id: 521045:KOLE_RS09430
uniprot id: C5CGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

521045:KOLE RS09230
gene id: 521045:KOLE_RS09230
uniprot id: C5CFS5
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

521045:KOLE RS10745
gene id: 521045:KOLE_RS10745
uniprot id: C5CIA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

521045:KOLE RS04310
gene id: 521045:KOLE_RS04310
uniprot id: C5CGC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

521045:KOLE RS07030
gene id: 521045:KOLE_RS07030
uniprot id: C5CDZ3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

521045:KOLE RS10125
gene id: 521045:KOLE_RS10125
uniprot id: C5CH81
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

521045:KOLE RS01525
gene id: 521045:KOLE_RS01525
uniprot id: C5CD81
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

521045:KOLE RS06200
gene id: 521045:KOLE_RS06200
uniprot id: C5CJ10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

521045:KOLE RS08365
gene id: 521045:KOLE_RS08365
uniprot id: C5CFD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

521045:KOLE RS06160
gene id: 521045:KOLE_RS06160
uniprot id: C5CJ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS00885
gene id: 521045:KOLE_RS00885
uniprot id: C5CIG3
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

521045:KOLE RS01755
gene id: 521045:KOLE_RS01755
uniprot id: C5CDI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

521045:KOLE RS05855
gene id: 521045:KOLE_RS05855
uniprot id: C5CIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS10400
gene id: 521045:KOLE_RS10400
uniprot id: C5CHR0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07765
gene id: 521045:KOLE_RS07765
uniprot id: C5CEQ1
names: Similarity
messages: Belongs to the XseB family.

521045:KOLE RS04360
gene id: 521045:KOLE_RS04360
uniprot id: C5CGJ2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

521045:KOLE RS07315
gene id: 521045:KOLE_RS07315
uniprot id: C5CEA6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

521045:KOLE RS09485
gene id: 521045:KOLE_RS09485
uniprot id: C5CGH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

521045:KOLE RS05650
gene id: 521045:KOLE_RS05650
uniprot id: C5CI44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

521045:KOLE RS08175
gene id: 521045:KOLE_RS08175
uniprot id: C5CF45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

521045:KOLE RS10555
gene id: 521045:KOLE_RS10555
uniprot id: C5CI64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS09550
gene id: 521045:KOLE_RS09550
uniprot id: C5CGJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

521045:KOLE RS10165
gene id: 521045:KOLE_RS10165
uniprot id: C5CH88
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS05725
gene id: 521045:KOLE_RS05725
uniprot id: C5CIH6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

521045:KOLE RS10965
gene id: 521045:KOLE_RS10965
uniprot id: C5CIR4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

521045:KOLE RS03285
gene id: 521045:KOLE_RS03285
uniprot id: C5CF87
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

521045:KOLE RS09435
gene id: 521045:KOLE_RS09435
uniprot id: C5CGG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

521045:KOLE RS04495
gene id: 521045:KOLE_RS04495
uniprot id: C5CGL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

521045:KOLE RS05120
gene id: 521045:KOLE_RS05120
uniprot id: C5CHG4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

521045:KOLE RS01315
gene id: 521045:KOLE_RS01315
uniprot id: C5CD39
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

521045:KOLE RS02740
gene id: 521045:KOLE_RS02740
uniprot id: C5CEL3
names: Similarity
messages: Belongs to the UPF0111 family.

521045:KOLE RS04345
gene id: 521045:KOLE_RS04345
uniprot id: C5CGD0
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

521045:KOLE RS04525
gene id: 521045:KOLE_RS04525
uniprot id: C5CGM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

521045:KOLE RS00620
gene id: 521045:KOLE_RS00620
uniprot id: C5CHV2
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07610
gene id: 521045:KOLE_RS07610
uniprot id: C5CEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS01095
gene id: 521045:KOLE_RS01095
uniprot id: C5CIV1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

521045:KOLE RS09295
gene id: 521045:KOLE_RS09295
uniprot id: C5CGE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

521045:KOLE RS04990
gene id: 521045:KOLE_RS04990
uniprot id: C5CH32
names: Similarity
messages: Belongs to the TPP enzyme family.

521045:KOLE RS03595
gene id: 521045:KOLE_RS03595
uniprot id: C5CFK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

521045:KOLE RS05780
gene id: 521045:KOLE_RS05780
uniprot id: C5CII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS10025
gene id: 521045:KOLE_RS10025
uniprot id: C5CH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS01430
gene id: 521045:KOLE_RS01430
uniprot id: C5CD62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

521045:KOLE RS10955
gene id: 521045:KOLE_RS10955
uniprot id: C5CIR2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

521045:KOLE RS01895
gene id: 521045:KOLE_RS01895
uniprot id: C5CDS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

521045:KOLE RS07735
gene id: 521045:KOLE_RS07735
uniprot id: C5CEP5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

521045:KOLE RS06520
gene id: 521045:KOLE_RS06520
uniprot id: C5CDC5
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS04215
gene id: 521045:KOLE_RS04215
uniprot id: C5CGA4
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09500
gene id: 521045:KOLE_RS09500
uniprot id: C5CGI0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

521045:KOLE RS10285
gene id: 521045:KOLE_RS10285
uniprot id: C5CHN8
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

521045:KOLE RS10895
gene id: 521045:KOLE_RS10895
uniprot id: C5CIQ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS00685
gene id: 521045:KOLE_RS00685
uniprot id: C5CIC3
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01860
gene id: 521045:KOLE_RS01860
uniprot id: C5CDK3
names: Similarity
messages: Belongs to the UPF0047 family.

521045:KOLE RS01650
gene id: 521045:KOLE_RS01650
uniprot id: C5CDG6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

521045:KOLE RS07245
gene id: 521045:KOLE_RS07245
uniprot id: C5CE31
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

521045:KOLE RS08575
gene id: 521045:KOLE_RS08575
uniprot id: C5CFH6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

521045:KOLE RS06600
gene id: 521045:KOLE_RS06600
uniprot id: C5CDE3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

521045:KOLE RS03265
gene id: 521045:KOLE_RS03265
uniprot id: C5CF83
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07690
gene id: 521045:KOLE_RS07690
uniprot id: C5CEN6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

521045:KOLE RS07350
gene id: 521045:KOLE_RS07350
uniprot id: C5CEB3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

521045:KOLE RS01570
gene id: 521045:KOLE_RS01570
uniprot id: C5CD90
names: Similarity
messages: Belongs to the band 7/mec-2 family.

521045:KOLE RS08685
gene id: 521045:KOLE_RS08685
uniprot id: C5CFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

521045:KOLE RS05130
gene id: 521045:KOLE_RS05130
uniprot id: C5CHG6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Non-allosteric.

521045:KOLE RS08825
gene id: 521045:KOLE_RS08825
uniprot id: C5CFT8
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

521045:KOLE RS08010
gene id: 521045:KOLE_RS08010
uniprot id: C5CF10
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

521045:KOLE RS01245
gene id: 521045:KOLE_RS01245
uniprot id: C5CIS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521045:KOLE RS08115
gene id: 521045:KOLE_RS08115
uniprot id: C5CF35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

521045:KOLE RS10410
gene id: 521045:KOLE_RS10410
uniprot id: C5CHR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS02725
gene id: 521045:KOLE_RS02725
uniprot id: C5CEL0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

521045:KOLE RS07170
gene id: 521045:KOLE_RS07170
uniprot id: C5CE17
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

521045:KOLE RS00500
gene id: 521045:KOLE_RS00500
uniprot id: C5CHX0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

521045:KOLE RS00490
gene id: 521045:KOLE_RS00490
uniprot id: C5CHW8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

521045:KOLE RS09090
gene id: 521045:KOLE_RS09090
uniprot id: C5CFY7
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

521045:KOLE RS08265
gene id: 521045:KOLE_RS08265
uniprot id: C5CFC0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

521045:KOLE RS04395
gene id: 521045:KOLE_RS04395
uniprot id: C5CGJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

521045:KOLE RS08640
gene id: 521045:KOLE_RS08640
uniprot id: C5CFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

521045:KOLE RS07545
gene id: 521045:KOLE_RS07545
uniprot id: C5CEE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

521045:KOLE RS09505
gene id: 521045:KOLE_RS09505
uniprot id: C5CGI1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

521045:KOLE RS05760
gene id: 521045:KOLE_RS05760
uniprot id: C5CII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

521045:KOLE RS11715
gene id: 521045:KOLE_RS11715
uniprot id: C5CIU9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

521045:KOLE RS09360
gene id: 521045:KOLE_RS09360
uniprot id: C5CGF3
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

521045:KOLE RS04405
gene id: 521045:KOLE_RS04405
uniprot id: C5CGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS00355
gene id: 521045:KOLE_RS00355
uniprot id: C5CHT8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS10850
gene id: 521045:KOLE_RS10850
uniprot id: C5CIP1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

521045:KOLE RS04860
gene id: 521045:KOLE_RS04860
uniprot id: C5CH06
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

521045:KOLE RS09865
gene id: 521045:KOLE_RS09865
uniprot id: C5CGW5
names: Similarity
messages: Belongs to the Skp family.

521045:KOLE RS02095
gene id: 521045:KOLE_RS02095
uniprot id: C5CDW5
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

521045:KOLE RS08125
gene id: 521045:KOLE_RS08125
uniprot id: C5CF37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

521045:KOLE RS04910
gene id: 521045:KOLE_RS04910
uniprot id: C5CH16
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

521045:KOLE RS02175
gene id: 521045:KOLE_RS02175
uniprot id: C5CDY0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS02295
gene id: 521045:KOLE_RS02295
uniprot id: C5CE63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS07375
gene id: 521045:KOLE_RS07375
uniprot id: C5CEB8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

521045:KOLE RS05610
gene id: 521045:KOLE_RS05610
uniprot id: C5CI36
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

521045:KOLE RS06945
gene id: 521045:KOLE_RS06945
uniprot id: C5CDR8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS05705
gene id: 521045:KOLE_RS05705
uniprot id: C5CHZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

521045:KOLE RS07970
gene id: 521045:KOLE_RS07970
uniprot id: C5CF02
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS06225
gene id: 521045:KOLE_RS06225
uniprot id: C5CJ15
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

521045:KOLE RS05630
gene id: 521045:KOLE_RS05630
uniprot id: C5CI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

521045:KOLE RS05250
gene id: 521045:KOLE_RS05250
uniprot id: C5CHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS07120
gene id: 521045:KOLE_RS07120
uniprot id: C5CE09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

521045:KOLE RS05070
gene id: 521045:KOLE_RS05070
uniprot id: C5CHF6
names: Similarity
messages: Belongs to the peptidase U62 family.

521045:KOLE RS03060
gene id: 521045:KOLE_RS03060
uniprot id: C5CEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

521045:KOLE RS02855
gene id: 521045:KOLE_RS02855
uniprot id: C5CEU6
names: Similarity
messages: Belongs to the peptidase A31 family.

521045:KOLE RS10840
gene id: 521045:KOLE_RS10840
uniprot id: C5CIN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521045:KOLE RS06315
gene id: 521045:KOLE_RS06315
uniprot id: C5CJ34
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01345
gene id: 521045:KOLE_RS01345
uniprot id: C5CD45
names: Similarity
messages: Belongs to the IMPACT family.

521045:KOLE RS10405
gene id: 521045:KOLE_RS10405
uniprot id: C5CHR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS07655
gene id: 521045:KOLE_RS07655
uniprot id: C5CEM9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08780
gene id: 521045:KOLE_RS08780
uniprot id: C5CFS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

521045:KOLE RS01760
gene id: 521045:KOLE_RS01760
uniprot id: C5CDI2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

521045:KOLE RS04130
gene id: 521045:KOLE_RS04130
uniprot id: C5CG86
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

521045:KOLE RS00550
gene id: 521045:KOLE_RS00550
uniprot id: C5CHY0
names: Similarity
messages: Belongs to the diaminopimelate epimerase family.

521045:KOLE RS01875
gene id: 521045:KOLE_RS01875
uniprot id: C5CDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

521045:KOLE RS00525
gene id: 521045:KOLE_RS00525
uniprot id: C5CHX5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

521045:KOLE RS08300
gene id: 521045:KOLE_RS08300
uniprot id: B5M6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

521045:KOLE RS08350
gene id: 521045:KOLE_RS08350
uniprot id: C5CFD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

521045:KOLE RS08180
gene id: 521045:KOLE_RS08180
uniprot id: C5CF46
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

521045:KOLE RS09815
gene id: 521045:KOLE_RS09815
uniprot id: C5CGV5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

521045:KOLE RS08295
gene id: 521045:KOLE_RS08295
uniprot id: B5M6N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

521045:KOLE RS01325
gene id: 521045:KOLE_RS01325
uniprot id: C5CD41
names: Similarity
messages: Belongs to the CND3 (condensin subunit 3) family.

521045:KOLE RS04440
gene id: 521045:KOLE_RS04440
uniprot id: C5CGK7
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

521045:KOLE RS01265
gene id: 521045:KOLE_RS01265
uniprot id: C5CD29
names: Similarity
messages: Belongs to the asparaginase 1 family.

521045:KOLE RS09520
gene id: 521045:KOLE_RS09520
uniprot id: C5CGI4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

521045:KOLE RS08225
gene id: 521045:KOLE_RS08225
uniprot id: B5M6M1
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

521045:KOLE RS09750
gene id: 521045:KOLE_RS09750
uniprot id: C5CGU2
names: Similarity
messages: Belongs to the ComB family.

521045:KOLE RS10680
gene id: 521045:KOLE_RS10680
uniprot id: C5CI88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

521045:KOLE RS07015
gene id: 521045:KOLE_RS07015
uniprot id: C5CDZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

521045:KOLE RS03925
gene id: 521045:KOLE_RS03925
uniprot id: C5CG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS10575
gene id: 521045:KOLE_RS10575
uniprot id: C5CI68
names: Similarity
messages: Belongs to the class-I fumarase family.

521045:KOLE RS03855
gene id: 521045:KOLE_RS03855
uniprot id: C5CG29
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01100
gene id: 521045:KOLE_RS01100
uniprot id: C5CIV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

521045:KOLE RS07635
gene id: 521045:KOLE_RS07635
uniprot id: C5CEG5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

521045:KOLE RS02445
gene id: 521045:KOLE_RS02445
uniprot id: C5CE97
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

521045:KOLE RS00835
gene id: 521045:KOLE_RS00835
uniprot id: C5CIF3
names: Similarity
messages: Belongs to the BtpA family.

521045:KOLE RS07820
gene id: 521045:KOLE_RS07820
uniprot id: C5CER2
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS02060
gene id: 521045:KOLE_RS02060
uniprot id: C5CDV8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

521045:KOLE RS09615
gene id: 521045:KOLE_RS09615
uniprot id: C5CGR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

521045:KOLE RS09975
gene id: 521045:KOLE_RS09975
uniprot id: C5CH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS06910
gene id: 521045:KOLE_RS06910
uniprot id: C5CDR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

521045:KOLE RS07365
gene id: 521045:KOLE_RS07365
uniprot id: C5CEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

521045:KOLE RS01530
gene id: 521045:KOLE_RS01530
uniprot id: C5CD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS10810
gene id: 521045:KOLE_RS10810
uniprot id: C5CIN3
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

521045:KOLE RS04400
gene id: 521045:KOLE_RS04400
uniprot id: C5CGJ9
names: Similarity
messages: Belongs to the peptidase S13 family.

521045:KOLE RS06330
gene id: 521045:KOLE_RS06330
uniprot id: C5CJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS06900
gene id: 521045:KOLE_RS06900
uniprot id: C5CDQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS08565
gene id: 521045:KOLE_RS08565
uniprot id: C5CFH4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

521045:KOLE RS04145
gene id: 521045:KOLE_RS04145
uniprot id: C5CG89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

521045:KOLE RS03705
gene id: 521045:KOLE_RS03705
uniprot id: C5CFM7
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

521045:KOLE RS00015
gene id: 521045:KOLE_RS00015
uniprot id: C5CH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

521045:KOLE RS10875
gene id: 521045:KOLE_RS10875
uniprot id: C5CIP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

521045:KOLE RS10075
gene id: 521045:KOLE_RS10075
uniprot id: C5CH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS07260
gene id: 521045:KOLE_RS07260
uniprot id: C5CE34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

521045:KOLE RS10655
gene id: 521045:KOLE_RS10655
uniprot id: C5CI83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521045:KOLE RS01320
gene id: 521045:KOLE_RS01320
uniprot id: C5CD40
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

521045:KOLE RS08760
gene id: 521045:KOLE_RS08760
uniprot id: C5CFS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

521045:KOLE RS10940
gene id: 521045:KOLE_RS10940
uniprot id: C5CIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

521045:KOLE RS04250
gene id: 521045:KOLE_RS04250
uniprot id: C5CGB1
names: Similarity
messages: Belongs to the GSP E family.

521045:KOLE RS00095
gene id: 521045:KOLE_RS00095
uniprot id: C5CHA8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

521045:KOLE RS07515
gene id: 521045:KOLE_RS07515
uniprot id: C5CEE3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

521045:KOLE RS08960
gene id: 521045:KOLE_RS08960
uniprot id: C5CFW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

521045:KOLE RS07850
gene id: 521045:KOLE_RS07850
uniprot id: C5CER8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

521045:KOLE RS08965
gene id: 521045:KOLE_RS08965
uniprot id: C5CFW3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

521045:KOLE RS07805
gene id: 521045:KOLE_RS07805
uniprot id: C5CEQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS08305
gene id: 521045:KOLE_RS08305
uniprot id: B5M6N6
names: Similarity
messages: Belongs to the peptidase M16 family.

521045:KOLE RS05795
gene id: 521045:KOLE_RS05795
uniprot id: C5CII9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01310
gene id: 521045:KOLE_RS01310
uniprot id: C5CD38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

521045:KOLE RS05255
gene id: 521045:KOLE_RS05255
uniprot id: C5CHI9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

521045:KOLE RS08580
gene id: 521045:KOLE_RS08580
uniprot id: C5CFF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

521045:KOLE RS00760
gene id: 521045:KOLE_RS00760
uniprot id: C5CID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS10650
gene id: 521045:KOLE_RS10650
uniprot id: C5CI82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

521045:KOLE RS08765
gene id: 521045:KOLE_RS08765
uniprot id: C5CFS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

521045:KOLE RS08480
gene id: 521045:KOLE_RS08480
uniprot id: C5CFF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS03585
gene id: 521045:KOLE_RS03585
uniprot id: C5CFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

521045:KOLE RS10455
gene id: 521045:KOLE_RS10455
uniprot id: C5CHS0
names: Subcellular Location Annotation
messages: Cytoplasm

521045:KOLE RS09355
gene id: 521045:KOLE_RS09355
uniprot id: C5CGF2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

521045:KOLE RS05595
gene id: 521045:KOLE_RS05595
uniprot id: C5CI33
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01180
gene id: 521045:KOLE_RS01180
uniprot id: C5CIW8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

521045:KOLE RS01040
gene id: 521045:KOLE_RS01040
uniprot id: C5CIU0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10395
gene id: 521045:KOLE_RS10395
uniprot id: C5CHQ9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08995
gene id: 521045:KOLE_RS08995
uniprot id: C5CFW9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS06720
gene id: 521045:KOLE_RS06720
uniprot id: C5CDM4
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS03240
gene id: 521045:KOLE_RS03240
uniprot id: C5CF78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

521045:KOLE RS09720
gene id: 521045:KOLE_RS09720
uniprot id: C5CGT6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

521045:KOLE RS01295
gene id: 521045:KOLE_RS01295
uniprot id: C5CD35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).

521045:KOLE RS10385
gene id: 521045:KOLE_RS10385
uniprot id: C5CHQ7
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00535
gene id: 521045:KOLE_RS00535
uniprot id: C5CHX7
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

521045:KOLE RS06205
gene id: 521045:KOLE_RS06205
uniprot id: C5CJ11
names: Similarity
messages: Belongs to the citrate synthase family.

521045:KOLE RS03865
gene id: 521045:KOLE_RS03865
uniprot id: C5CG31
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10155
gene id: 521045:KOLE_RS10155
uniprot id: C5CH86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

521045:KOLE RS08520
gene id: 521045:KOLE_RS08520
uniprot id: C5CFG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

521045:KOLE RS07165
gene id: 521045:KOLE_RS07165
uniprot id: C5CE16
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS09600
gene id: 521045:KOLE_RS09600
uniprot id: C5CGR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

521045:KOLE RS10660
gene id: 521045:KOLE_RS10660
uniprot id: C5CI84
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

521045:KOLE RS09450
gene id: 521045:KOLE_RS09450
uniprot id: C5CGH0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

521045:KOLE RS00840
gene id: 521045:KOLE_RS00840
uniprot id: C5CIF4
names: Similarity
messages: Belongs to the FGGY kinase family.

521045:KOLE RS04700
gene id: 521045:KOLE_RS04700
uniprot id: C5CGX5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08720
gene id: 521045:KOLE_RS08720
uniprot id: C5CFR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

521045:KOLE RS05545
gene id: 521045:KOLE_RS05545
uniprot id: C5CI23
names: Similarity
messages: Belongs to the peptidase C1 family.

521045:KOLE RS09605
gene id: 521045:KOLE_RS09605
uniprot id: C5CGR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

521045:KOLE RS04350
gene id: 521045:KOLE_RS04350
uniprot id: C5CGD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

521045:KOLE RS02365
gene id: 521045:KOLE_RS02365
uniprot id: C5CE77
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08905
gene id: 521045:KOLE_RS08905
uniprot id: C5CFV1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

521045:KOLE RS04065
gene id: 521045:KOLE_RS04065
uniprot id: C5CG73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

521045:KOLE RS08035
gene id: 521045:KOLE_RS08035
uniprot id: C5CF15
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

521045:KOLE RS09830
gene id: 521045:KOLE_RS09830
uniprot id: C5CGV8
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

521045:KOLE RS06805
gene id: 521045:KOLE_RS06805
uniprot id: C5CDP1
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

521045:KOLE RS03275
gene id: 521045:KOLE_RS03275
uniprot id: C5CF85
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

521045:KOLE RS09850
gene id: 521045:KOLE_RS09850
uniprot id: C5CGW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521045:KOLE RS06895
gene id: 521045:KOLE_RS06895
uniprot id: C5CDQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

521045:KOLE RS09575
gene id: 521045:KOLE_RS09575
uniprot id: C5CGQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

521045:KOLE RS00970
gene id: 521045:KOLE_RS00970
uniprot id: C5CIS3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

521045:KOLE RS08370
gene id: 521045:KOLE_RS08370
uniprot id: C5CFD5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

521045:KOLE RS00450
gene id: 521045:KOLE_RS00450
uniprot id: C5CHW0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

521045:KOLE RS07200
gene id: 521045:KOLE_RS07200
uniprot id: C5CE22
names: Similarity
messages: Belongs to the carbamate kinase family.

521045:KOLE RS07490
gene id: 521045:KOLE_RS07490
uniprot id: C5CED8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

521045:KOLE RS02920
gene id: 521045:KOLE_RS02920
uniprot id: C5CEV6
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09400
gene id: 521045:KOLE_RS09400
uniprot id: C5CGG1
names: Similarity
messages: Belongs to the bacterial secretin family.

521045:KOLE RS10465
gene id: 521045:KOLE_RS10465
uniprot id: C5CHS3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

521045:KOLE RS08355
gene id: 521045:KOLE_RS08355
uniprot id: C5CFD2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

521045:KOLE RS08095
gene id: 521045:KOLE_RS08095
uniprot id: C5CF31
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

521045:KOLE RS02875
gene id: 521045:KOLE_RS02875
uniprot id: C5CEV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS04600
gene id: 521045:KOLE_RS04600
uniprot id: C5CGP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

521045:KOLE RS09460
gene id: 521045:KOLE_RS09460
uniprot id: C5CGH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

521045:KOLE RS00745
gene id: 521045:KOLE_RS00745
uniprot id: C5CID6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

521045:KOLE RS08185
gene id: 521045:KOLE_RS08185
uniprot id: C5CF47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

521045:KOLE RS10630
gene id: 521045:KOLE_RS10630
uniprot id: C5CI78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

521045:KOLE RS07475
gene id: 521045:KOLE_RS07475
uniprot id: C5CED5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS03535
gene id: 521045:KOLE_RS03535
uniprot id: C5CFJ5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS05295
gene id: 521045:KOLE_RS05295
uniprot id: C5CHJ7
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS08750
gene id: 521045:KOLE_RS08750
uniprot id: C5CFR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

521045:KOLE RS03000
gene id: 521045:KOLE_RS03000
uniprot id: C5CEX3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

521045:KOLE RS05755
gene id: 521045:KOLE_RS05755
uniprot id: C5CII1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

521045:KOLE RS04115
gene id: 521045:KOLE_RS04115
uniprot id: C5CG83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09535
gene id: 521045:KOLE_RS09535
uniprot id: C5CGI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

521045:KOLE RS07425
gene id: 521045:KOLE_RS07425
uniprot id: C5CEC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

521045:KOLE RS09795
gene id: 521045:KOLE_RS09795
uniprot id: C5CGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

521045:KOLE RS00640
gene id: 521045:KOLE_RS00640
uniprot id: C5CIB5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

521045:KOLE RS00770
gene id: 521045:KOLE_RS00770
uniprot id: C5CIE1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

521045:KOLE RS04570
gene id: 521045:KOLE_RS04570
uniprot id: C5CGN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

521045:KOLE RS09345
gene id: 521045:KOLE_RS09345
uniprot id: C5CGF0
names: Similarity
messages: Belongs to the RemA family.

521045:KOLE RS01670
gene id: 521045:KOLE_RS01670
uniprot id: C5CDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

521045:KOLE RS09260
gene id: 521045:KOLE_RS09260
uniprot id: C5CGD5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07130
gene id: 521045:KOLE_RS07130
uniprot id: C5CE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS02635
gene id: 521045:KOLE_RS02635
uniprot id: C5CEJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

521045:KOLE RS09710
gene id: 521045:KOLE_RS09710
uniprot id: C5CGT4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

521045:KOLE RS05060
gene id: 521045:KOLE_RS05060
uniprot id: C5CHF4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

521045:KOLE RS09665
gene id: 521045:KOLE_RS09665
uniprot id: C5CGS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

521045:KOLE RS04545
gene id: 521045:KOLE_RS04545
uniprot id: C5CGM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

521045:KOLE RS02730
gene id: 521045:KOLE_RS02730
uniprot id: C5CEL1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

521045:KOLE RS08650
gene id: 521045:KOLE_RS08650
uniprot id: C5CFQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

521045:KOLE RS09540
gene id: 521045:KOLE_RS09540
uniprot id: C5CGI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

521045:KOLE RS08680
gene id: 521045:KOLE_RS08680
uniprot id: C5CFQ5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00235
gene id: 521045:KOLE_RS00235
uniprot id: C5CHD3
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00615
gene id: 521045:KOLE_RS00615
uniprot id: C5CHZ0
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01425
gene id: 521045:KOLE_RS01425
uniprot id: C5CD61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

521045:KOLE RS05910
gene id: 521045:KOLE_RS05910
uniprot id: C5CIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09620
gene id: 521045:KOLE_RS09620
uniprot id: C5CGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

521045:KOLE RS03615
gene id: 521045:KOLE_RS03615
uniprot id: C5CFL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

521045:KOLE RS07455
gene id: 521045:KOLE_RS07455
uniprot id: C5CED3
names: Similarity
messages: Belongs to the RecJ family.

521045:KOLE RS09315
gene id: 521045:KOLE_RS09315
uniprot id: C5CGE6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

521045:KOLE RS10195
gene id: 521045:KOLE_RS10195
uniprot id: C5CHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

521045:KOLE RS06825
gene id: 521045:KOLE_RS06825
uniprot id: C5CDP6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

521045:KOLE RS03610
gene id: 521045:KOLE_RS03610
uniprot id: C5CFL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

521045:KOLE RS06155
gene id: 521045:KOLE_RS06155
uniprot id: C5CJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS01075
gene id: 521045:KOLE_RS01075
uniprot id: C5CIU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS06960
gene id: 521045:KOLE_RS06960
uniprot id: C5CDS1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

521045:KOLE RS00940
gene id: 521045:KOLE_RS00940
uniprot id: C5CIR7
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

521045:KOLE RS01155
gene id: 521045:KOLE_RS01155
uniprot id: C5CIW2
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

521045:KOLE RS07695
gene id: 521045:KOLE_RS07695
uniprot id: C5CEN7
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS05235
gene id: 521045:KOLE_RS05235
uniprot id: C5CHI5
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

521045:KOLE RS08850
gene id: 521045:KOLE_RS08850
uniprot id: C5CFU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS01765
gene id: 521045:KOLE_RS01765
uniprot id: C5CDI3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

521045:KOLE RS09570
gene id: 521045:KOLE_RS09570
uniprot id: C5CGQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

521045:KOLE RS09565
gene id: 521045:KOLE_RS09565
uniprot id: C5CGQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

521045:KOLE RS08990
gene id: 521045:KOLE_RS08990
uniprot id: C5CFW8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

521045:KOLE RS10370
gene id: 521045:KOLE_RS10370
uniprot id: C5CHQ4
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

521045:KOLE RS09870
gene id: 521045:KOLE_RS09870
uniprot id: C5CGW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS00060
gene id: 521045:KOLE_RS00060
uniprot id: C5CHA1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

521045:KOLE RS06265
gene id: 521045:KOLE_RS06265
uniprot id: C5CJ23
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

521045:KOLE RS01920
gene id: 521045:KOLE_RS01920
uniprot id: C5CDT1
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07710
gene id: 521045:KOLE_RS07710
uniprot id: C5CEP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

521045:KOLE RS03280
gene id: 521045:KOLE_RS03280
uniprot id: C5CF86
names: Similarity
messages: Belongs to the FBPase class 2 family.

521045:KOLE RS04775
gene id: 521045:KOLE_RS04775
uniprot id: C5CGZ0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521045:KOLE RS09785
gene id: 521045:KOLE_RS09785
uniprot id: C5CGU9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

521045:KOLE RS00555
gene id: 521045:KOLE_RS00555
uniprot id: C5CHY1
names: Subunit
messages: Homodimer.

521045:KOLE RS00515
gene id: 521045:KOLE_RS00515
uniprot id: C5CHX3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

521045:KOLE RS09480
gene id: 521045:KOLE_RS09480
uniprot id: C5CGH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

521045:KOLE RS07815
gene id: 521045:KOLE_RS07815
uniprot id: C5CER1
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09805
gene id: 521045:KOLE_RS09805
uniprot id: C5CGV3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS07985
gene id: 521045:KOLE_RS07985
uniprot id: C5CF05
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

521045:KOLE RS10865
gene id: 521045:KOLE_RS10865
uniprot id: C5CIP4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

521045:KOLE RS07335
gene id: 521045:KOLE_RS07335
uniprot id: C5CEB0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

521045:KOLE RS09170
gene id: 521045:KOLE_RS09170
uniprot id: C5CG04
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521045:KOLE RS00315
gene id: 521045:KOLE_RS00315
uniprot id: C5CHT0
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS10550
gene id: 521045:KOLE_RS10550
uniprot id: C5CI63
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

521045:KOLE RS09875
gene id: 521045:KOLE_RS09875
uniprot id: C5CGW7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

521045:KOLE RS09440
gene id: 521045:KOLE_RS09440
uniprot id: C5CGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

521045:KOLE RS09395
gene id: 521045:KOLE_RS09395
uniprot id: C5CGG0
names: Similarity
messages: Belongs to the MEMO1 family.

521045:KOLE RS08955
gene id: 521045:KOLE_RS08955
uniprot id: C5CFW1
names: Similarity
messages: Belongs to the CinA family.

521045:KOLE RS04430
gene id: 521045:KOLE_RS04430
uniprot id: C5CGK5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

521045:KOLE RS01455
gene id: 521045:KOLE_RS01455
uniprot id: C5CD67
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

521045:KOLE RS07750
gene id: 521045:KOLE_RS07750
uniprot id: C5CEP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

521045:KOLE RS11025
gene id: 521045:KOLE_RS11025
uniprot id: C5CEA1
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS02715
gene id: 521045:KOLE_RS02715
uniprot id: C5CEK8
names: Similarity
messages: Belongs to the FGGY kinase family.

521045:KOLE RS09610
gene id: 521045:KOLE_RS09610
uniprot id: C5CGR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

521045:KOLE RS03355
gene id: 521045:KOLE_RS03355
uniprot id: C5CFA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

521045:KOLE RS01805
gene id: 521045:KOLE_RS01805
uniprot id: C5CDJ2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

521045:KOLE RS07300
gene id: 521045:KOLE_RS07300
uniprot id: C5CE41
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

521045:KOLE RS08210
gene id: 521045:KOLE_RS08210
uniprot id: B5M6L7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

521045:KOLE RS04900
gene id: 521045:KOLE_RS04900
uniprot id: C5CH14
names: Similarity
messages: Belongs to the fabD family.

521045:KOLE RS02250
gene id: 521045:KOLE_RS02250
uniprot id: C5CE54
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS04565
gene id: 521045:KOLE_RS04565
uniprot id: C5CGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

521045:KOLE RS08675
gene id: 521045:KOLE_RS08675
uniprot id: C5CFQ4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

521045:KOLE RS10580
gene id: 521045:KOLE_RS10580
uniprot id: C5CI69
names: Similarity
messages: Belongs to the class-I fumarase family.

521045:KOLE RS09900
gene id: 521045:KOLE_RS09900
uniprot id: C5CH38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS02350
gene id: 521045:KOLE_RS02350
uniprot id: C5CE74
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00245
gene id: 521045:KOLE_RS00245
uniprot id: C5CHD5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

521045:KOLE RS10185
gene id: 521045:KOLE_RS10185
uniprot id: C5CHL9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

521045:KOLE RS10110
gene id: 521045:KOLE_RS10110
uniprot id: C5CH78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09775
gene id: 521045:KOLE_RS09775
uniprot id: C5CGU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

521045:KOLE RS04460
gene id: 521045:KOLE_RS04460
uniprot id: C5CGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS05905
gene id: 521045:KOLE_RS05905
uniprot id: C5CIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS04575
gene id: 521045:KOLE_RS04575
uniprot id: C5CGN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

521045:KOLE RS04470
gene id: 521045:KOLE_RS04470
uniprot id: C5CGL2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

521045:KOLE RS05395
gene id: 521045:KOLE_RS05395
uniprot id: C5CHL7
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

521045:KOLE RS02975
gene id: 521045:KOLE_RS02975
uniprot id: C5CEW8
names: Similarity
messages: Belongs to the acylphosphatase family.

521045:KOLE RS08820
gene id: 521045:KOLE_RS08820
uniprot id: C5CFT7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

521045:KOLE RS04275
gene id: 521045:KOLE_RS04275
uniprot id: C5CGB6
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

521045:KOLE RS09255
gene id: 521045:KOLE_RS09255
uniprot id: C5CGD4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

521045:KOLE RS02825
gene id: 521045:KOLE_RS02825
uniprot id: C5CEU0
names: Similarity
messages: Belongs to the peptidase U62 family.

521045:KOLE RS07310
gene id: 521045:KOLE_RS07310
uniprot id: C5CE43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

521045:KOLE RS00910
gene id: 521045:KOLE_RS00910
uniprot id: C5CIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

521045:KOLE RS08625
gene id: 521045:KOLE_RS08625
uniprot id: C5CFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

521045:KOLE RS01855
gene id: 521045:KOLE_RS01855
uniprot id: C5CDK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

521045:KOLE RS01675
gene id: 521045:KOLE_RS01675
uniprot id: C5CDH1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

521045:KOLE RS04820
gene id: 521045:KOLE_RS04820
uniprot id: C5CGZ9
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS03425
gene id: 521045:KOLE_RS03425
uniprot id: C5CFB4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

521045:KOLE RS03395
gene id: 521045:KOLE_RS03395
uniprot id: C5CFA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

521045:KOLE RS08740
gene id: 521045:KOLE_RS08740
uniprot id: C5CFR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

521045:KOLE RS09285
gene id: 521045:KOLE_RS09285
uniprot id: C5CGE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

521045:KOLE RS10760
gene id: 521045:KOLE_RS10760
uniprot id: C5CIA4
names: Similarity
messages: Belongs to the UPF0473 family.

521045:KOLE RS08055
gene id: 521045:KOLE_RS08055
uniprot id: C5CF19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS03905
gene id: 521045:KOLE_RS03905
uniprot id: C5CG41
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

521045:KOLE RS08060
gene id: 521045:KOLE_RS08060
uniprot id: C5CF24
names: Similarity
messages: Belongs to the peptidase S1C family.

521045:KOLE RS02930
gene id: 521045:KOLE_RS02930
uniprot id: C5CEV8
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

521045:KOLE RS10390
gene id: 521045:KOLE_RS10390
uniprot id: C5CHQ8
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07345
gene id: 521045:KOLE_RS07345
uniprot id: C5CEB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

521045:KOLE RS07745
gene id: 521045:KOLE_RS07745
uniprot id: C5CEP7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS00485
gene id: 521045:KOLE_RS00485
uniprot id: C5CHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

521045:KOLE RS10950
gene id: 521045:KOLE_RS10950
uniprot id: C5CIR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS11115
gene id: 521045:KOLE_RS11115
uniprot id: C5CGZ6
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00100
gene id: 521045:KOLE_RS00100
uniprot id: C5CHA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

521045:KOLE RS06190
gene id: 521045:KOLE_RS06190
uniprot id: C5CJ08
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

521045:KOLE RS02670
gene id: 521045:KOLE_RS02670
uniprot id: C5CEK0
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

521045:KOLE RS04450
gene id: 521045:KOLE_RS04450
uniprot id: C5CGK9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

521045:KOLE RS04940
gene id: 521045:KOLE_RS04940
uniprot id: C5CH22
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

521045:KOLE RS00200
gene id: 521045:KOLE_RS00200
uniprot id: C5CHC9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

521045:KOLE RS09020
gene id: 521045:KOLE_RS09020
uniprot id: C5CFX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

521045:KOLE RS03450
gene id: 521045:KOLE_RS03450
uniprot id: C5CFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS10200
gene id: 521045:KOLE_RS10200
uniprot id: C5CHM2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

521045:KOLE RS01770
gene id: 521045:KOLE_RS01770
uniprot id: C5CDI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

521045:KOLE RS09515
gene id: 521045:KOLE_RS09515
uniprot id: C5CGI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

521045:KOLE RS06515
gene id: 521045:KOLE_RS06515
uniprot id: C5CDC4
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

521045:KOLE RS08615
gene id: 521045:KOLE_RS08615
uniprot id: C5CFP3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

521045:KOLE RS07230
gene id: 521045:KOLE_RS07230
uniprot id: C5CE28
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

521045:KOLE RS07905
gene id: 521045:KOLE_RS07905
uniprot id: C5CES8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

521045:KOLE RS06790
gene id: 521045:KOLE_RS06790
uniprot id: C5CDN8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

521045:KOLE RS00630
gene id: 521045:KOLE_RS00630
uniprot id: C5CIB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS07865
gene id: 521045:KOLE_RS07865
uniprot id: C5CES1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

521045:KOLE RS00975
gene id: 521045:KOLE_RS00975
uniprot id: C5CIS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

521045:KOLE RS10260
gene id: 521045:KOLE_RS10260
uniprot id: C5CHN4
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

521045:KOLE RS00020
gene id: 521045:KOLE_RS00020
uniprot id: C5CH93
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS00865
gene id: 521045:KOLE_RS00865
uniprot id: C5CIF9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

521045:KOLE RS00800
gene id: 521045:KOLE_RS00800
uniprot id: C5CIE7
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07355
gene id: 521045:KOLE_RS07355
uniprot id: C5CEB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

521045:KOLE RS00085
gene id: 521045:KOLE_RS00085
uniprot id: C5CHA6
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09580
gene id: 521045:KOLE_RS09580
uniprot id: C5CGQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

521045:KOLE RS06930
gene id: 521045:KOLE_RS06930
uniprot id: C5CDR5
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

521045:KOLE RS01475
gene id: 521045:KOLE_RS01475
uniprot id: C5CD71
names: Similarity
messages: Belongs to the glutamine synthetase family.

521045:KOLE RS09985
gene id: 521045:KOLE_RS09985
uniprot id: C5CH55
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

521045:KOLE RS03870
gene id: 521045:KOLE_RS03870
uniprot id: C5CG32
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

521045:KOLE RS06970
gene id: 521045:KOLE_RS06970
uniprot id: C5CDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS03605
gene id: 521045:KOLE_RS03605
uniprot id: C5CFK9
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

521045:KOLE RS02600
gene id: 521045:KOLE_RS02600
uniprot id: C5CEI7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS09280
gene id: 521045:KOLE_RS09280
uniprot id: C5CGD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

521045:KOLE RS07325
gene id: 521045:KOLE_RS07325
uniprot id: C5CEA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS11275
gene id: 521045:KOLE_RS11275
uniprot id: C5CI91
names: Similarity
messages: Belongs to the asp23 family.

521045:KOLE RS09370
gene id: 521045:KOLE_RS09370
uniprot id: C5CGF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

521045:KOLE RS07395
gene id: 521045:KOLE_RS07395
uniprot id: C5CEC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

521045:KOLE RS08810
gene id: 521045:KOLE_RS08810
uniprot id: C5CFT5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

521045:KOLE RS00860
gene id: 521045:KOLE_RS00860
uniprot id: C5CIF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS01535
gene id: 521045:KOLE_RS01535
uniprot id: C5CD83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS03785
gene id: 521045:KOLE_RS03785
uniprot id: C5CG18
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

521045:KOLE RS08245
gene id: 521045:KOLE_RS08245
uniprot id: B5M6M5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07340
gene id: 521045:KOLE_RS07340
uniprot id: C5CEB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

521045:KOLE RS07135
gene id: 521045:KOLE_RS07135
uniprot id: C5CE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09275
gene id: 521045:KOLE_RS09275
uniprot id: C5CGD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

521045:KOLE RS01010
gene id: 521045:KOLE_RS01010
uniprot id: C5CIT4
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00660
gene id: 521045:KOLE_RS00660
uniprot id: C5CIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

521045:KOLE RS09265
gene id: 521045:KOLE_RS09265
uniprot id: C5CGD6
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS03550
gene id: 521045:KOLE_RS03550
uniprot id: C5CFJ8
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

521045:KOLE RS03630
gene id: 521045:KOLE_RS03630
uniprot id: C5CFL3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS00545
gene id: 521045:KOLE_RS00545
uniprot id: C5CHX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

521045:KOLE RS05405
gene id: 521045:KOLE_RS05405
uniprot id: C5CHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS07880
gene id: 521045:KOLE_RS07880
uniprot id: C5CES4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

521045:KOLE RS08140
gene id: 521045:KOLE_RS08140
uniprot id: C5CF39
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS00255
gene id: 521045:KOLE_RS00255
uniprot id: C5CHD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

521045:KOLE RS08100
gene id: 521045:KOLE_RS08100
uniprot id: C5CF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

521045:KOLE RS02605
gene id: 521045:KOLE_RS02605
uniprot id: C5CEI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

521045:KOLE RS10265
gene id: 521045:KOLE_RS10265
uniprot id: C5CHN5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS02555
gene id: 521045:KOLE_RS02555
uniprot id: C5CEH8
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07940
gene id: 521045:KOLE_RS07940
uniprot id: C5CET5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

521045:KOLE RS02870
gene id: 521045:KOLE_RS02870
uniprot id: C5CEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS03545
gene id: 521045:KOLE_RS03545
uniprot id: C5CFJ7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

521045:KOLE RS03400
gene id: 521045:KOLE_RS03400
uniprot id: C5CFA9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

521045:KOLE RS03970
gene id: 521045:KOLE_RS03970
uniprot id: C5CG57
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS06220
gene id: 521045:KOLE_RS06220
uniprot id: C5CJ14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

521045:KOLE RS04245
gene id: 521045:KOLE_RS04245
uniprot id: C5CGB0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

521045:KOLE RS06925
gene id: 521045:KOLE_RS06925
uniprot id: C5CDR4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS09545
gene id: 521045:KOLE_RS09545
uniprot id: C5CGI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

521045:KOLE RS06435
gene id: 521045:KOLE_RS06435
uniprot id: C5CDB1
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

521045:KOLE RS06065
gene id: 521045:KOLE_RS06065
uniprot id: C5CIY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09560
gene id: 521045:KOLE_RS09560
uniprot id: C5CGQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

521045:KOLE RS02515
gene id: 521045:KOLE_RS02515
uniprot id: C5CEH0
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

521045:KOLE RS06975
gene id: 521045:KOLE_RS06975
uniprot id: C5CDY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

521045:KOLE RS04325
gene id: 521045:KOLE_RS04325
uniprot id: C5CGC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

521045:KOLE RS02765
gene id: 521045:KOLE_RS02765
uniprot id: C5CEL8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

521045:KOLE RS07760
gene id: 521045:KOLE_RS07760
uniprot id: C5CEQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

521045:KOLE RS08455
gene id: 521045:KOLE_RS08455
uniprot id: C5CFF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS00950
gene id: 521045:KOLE_RS00950
uniprot id: C5CIR9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

521045:KOLE RS02495
gene id: 521045:KOLE_RS02495
uniprot id: C5CE93
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

521045:KOLE RS02880
gene id: 521045:KOLE_RS02880
uniprot id: C5CEV1
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS03565
gene id: 521045:KOLE_RS03565
uniprot id: C5CFK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

521045:KOLE RS07405
gene id: 521045:KOLE_RS07405
uniprot id: C5CEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS05870
gene id: 521045:KOLE_RS05870
uniprot id: C5CIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS01750
gene id: 521045:KOLE_RS01750
uniprot id: C5CDI0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

521045:KOLE RS00695
gene id: 521045:KOLE_RS00695
uniprot id: C5CIC5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

521045:KOLE RS02120
gene id: 521045:KOLE_RS02120
uniprot id: C5CDX0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

521045:KOLE RS09635
gene id: 521045:KOLE_RS09635
uniprot id: C5CGR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

521045:KOLE RS02045
gene id: 521045:KOLE_RS02045
uniprot id: C5CDV5
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS08360
gene id: 521045:KOLE_RS08360
uniprot id: C5CFD3
names: Similarity
messages: Belongs to the DprA/Smf family.

521045:KOLE RS08665
gene id: 521045:KOLE_RS08665
uniprot id: C5CFQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521045:KOLE RS00600
gene id: 521045:KOLE_RS00600
uniprot id: C5CHY7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

521045:KOLE RS10350
gene id: 521045:KOLE_RS10350
uniprot id: C5CHQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS01120
gene id: 521045:KOLE_RS01120
uniprot id: C5CIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

521045:KOLE RS01115
gene id: 521045:KOLE_RS01115
uniprot id: C5CIV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

521045:KOLE RS09700
gene id: 521045:KOLE_RS09700
uniprot id: C5CGT2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

521045:KOLE RS09765
gene id: 521045:KOLE_RS09765
uniprot id: C5CGU5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

521045:KOLE RS04500
gene id: 521045:KOLE_RS04500
uniprot id: C5CGL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

521045:KOLE RS08110
gene id: 521045:KOLE_RS08110
uniprot id: C5CF34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

521045:KOLE RS04045
gene id: 521045:KOLE_RS04045
uniprot id: C5CG70
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09705
gene id: 521045:KOLE_RS09705
uniprot id: C5CGT3
names: Caution
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS00075
gene id: 521045:KOLE_RS00075
uniprot id: C5CHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

521045:KOLE RS00925
gene id: 521045:KOLE_RS00925
uniprot id: C5CIH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS06465
gene id: 521045:KOLE_RS06465
uniprot id: C5CDB5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS00560
gene id: 521045:KOLE_RS00560
uniprot id: C5CHY2
names: Subcellular Location Annotation
messages: Cytoplasm

521045:KOLE RS05410
gene id: 521045:KOLE_RS05410
uniprot id: C5CHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS09525
gene id: 521045:KOLE_RS09525
uniprot id: C5CGI5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

521045:KOLE RS10735
gene id: 521045:KOLE_RS10735
uniprot id: C5CI99
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

521045:KOLE RS10345
gene id: 521045:KOLE_RS10345
uniprot id: C5CHP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS01935
gene id: 521045:KOLE_RS01935
uniprot id: C5CDT4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

521045:KOLE RS05380
gene id: 521045:KOLE_RS05380
uniprot id: C5CHL4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521045:KOLE RS07050
gene id: 521045:KOLE_RS07050
uniprot id: C5CDZ7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

521045:KOLE RS08170
gene id: 521045:KOLE_RS08170
uniprot id: C5CF44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

521045:KOLE RS07770
gene id: 521045:KOLE_RS07770
uniprot id: C5CEQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XseA family.
messages: Cytoplasm

521045:KOLE RS08105
gene id: 521045:KOLE_RS08105
uniprot id: C5CF33
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

521045:KOLE RS02390
gene id: 521045:KOLE_RS02390
uniprot id: C5CE82
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07450
gene id: 521045:KOLE_RS07450
uniprot id: C5CED2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

521045:KOLE RS10960
gene id: 521045:KOLE_RS10960
uniprot id: C5CIR3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

521045:KOLE RS05085
gene id: 521045:KOLE_RS05085
uniprot id: C5CHF9
names: Similarity
messages: Belongs to the peptidase C69 family.

521045:KOLE RS08475
gene id: 521045:KOLE_RS08475
uniprot id: C5CFF7
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

521045:KOLE RS02885
gene id: 521045:KOLE_RS02885
uniprot id: C5CEV2
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS10935
gene id: 521045:KOLE_RS10935
uniprot id: C5CIQ8
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

521045:KOLE RS00195
gene id: 521045:KOLE_RS00195
uniprot id: C5CHC8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

521045:KOLE RS08495
gene id: 521045:KOLE_RS08495
uniprot id: C5CFG1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

521045:KOLE RS04540
gene id: 521045:KOLE_RS04540
uniprot id: C5CGM6
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

521045:KOLE RS09290
gene id: 521045:KOLE_RS09290
uniprot id: C5CGE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

521045:KOLE RS05460
gene id: 521045:KOLE_RS05460
uniprot id: C5CI06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

521045:KOLE RS08395
gene id: 521045:KOLE_RS08395
uniprot id: C5CFE0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

521045:KOLE RS07205
gene id: 521045:KOLE_RS07205
uniprot id: C5CE23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS01060
gene id: 521045:KOLE_RS01060
uniprot id: C5CIU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

521045:KOLE RS07780
gene id: 521045:KOLE_RS07780
uniprot id: C5CEQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm

521045:KOLE RS09490
gene id: 521045:KOLE_RS09490
uniprot id: C5CGH8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

521045:KOLE RS01130
gene id: 521045:KOLE_RS01130
uniprot id: C5CIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

521045:KOLE RS08590
gene id: 521045:KOLE_RS08590
uniprot id: C5CFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

521045:KOLE RS07890
gene id: 521045:KOLE_RS07890
uniprot id: C5CES6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

521045:KOLE RS07390
gene id: 521045:KOLE_RS07390
uniprot id: C5CEC0
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

521045:KOLE RS06940
gene id: 521045:KOLE_RS06940
uniprot id: C5CDR7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

521045:KOLE RS01135
gene id: 521045:KOLE_RS01135
uniprot id: C5CIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

521045:KOLE RS10640
gene id: 521045:KOLE_RS10640
uniprot id: C5CI80
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS02910
gene id: 521045:KOLE_RS02910
uniprot id: C5CEV4
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

521045:KOLE RS10805
gene id: 521045:KOLE_RS10805
uniprot id: C5CIN2
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

521045:KOLE RS02285
gene id: 521045:KOLE_RS02285
uniprot id: C5CE61
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

521045:KOLE RS10670
gene id: 521045:KOLE_RS10670
uniprot id: C5CI86
names: Similarity
messages: Belongs to the asp23 family.

521045:KOLE RS01065
gene id: 521045:KOLE_RS01065
uniprot id: C5CIU5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

521045:KOLE RS01595
gene id: 521045:KOLE_RS01595
uniprot id: C5CD95
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS00080
gene id: 521045:KOLE_RS00080
uniprot id: C5CHA5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS04595
gene id: 521045:KOLE_RS04595
uniprot id: C5CGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

521045:KOLE RS06310
gene id: 521045:KOLE_RS06310
uniprot id: C5CJ33
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS08815
gene id: 521045:KOLE_RS08815
uniprot id: C5CFT6
names: Similarity
messages: Belongs to the glutamine synthetase family.

521045:KOLE RS00700
gene id: 521045:KOLE_RS00700
uniprot id: C5CIC6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

521045:KOLE RS07800
gene id: 521045:KOLE_RS07800
uniprot id: C5CEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS06115
gene id: 521045:KOLE_RS06115
uniprot id: C5CIZ4
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01985
gene id: 521045:KOLE_RS01985
uniprot id: C5CDU3
names: Similarity
messages: Belongs to the peptidase S41A family.

521045:KOLE RS05020
gene id: 521045:KOLE_RS05020
uniprot id: C5CHE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

521045:KOLE RS07020
gene id: 521045:KOLE_RS07020
uniprot id: C5CDZ2
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS01880
gene id: 521045:KOLE_RS01880
uniprot id: C5CDS3
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07400
gene id: 521045:KOLE_RS07400
uniprot id: C5CEC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

521045:KOLE RS00920
gene id: 521045:KOLE_RS00920
uniprot id: C5CIH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

521045:KOLE RS01340
gene id: 521045:KOLE_RS01340
uniprot id: C5CD44
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

521045:KOLE RS04480
gene id: 521045:KOLE_RS04480
uniprot id: C5CGL4
names: Similarity
messages: Belongs to the UPF0111 family.

521045:KOLE RS06725
gene id: 521045:KOLE_RS06725
uniprot id: C5CDM5
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07605
gene id: 521045:KOLE_RS07605
uniprot id: C5CEF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS09770
gene id: 521045:KOLE_RS09770
uniprot id: C5CGU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

521045:KOLE RS02320
gene id: 521045:KOLE_RS02320
uniprot id: C5CE68
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

521045:KOLE RS01600
gene id: 521045:KOLE_RS01600
uniprot id: C5CD96
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

521045:KOLE RS00495
gene id: 521045:KOLE_RS00495
uniprot id: C5CHW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

521045:KOLE RS09675
gene id: 521045:KOLE_RS09675
uniprot id: C5CGS7
names: Similarity
messages: Belongs to the TlyA family.

521045:KOLE RS03175
gene id: 521045:KOLE_RS03175
uniprot id: C5CF65
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

521045:KOLE RS04475
gene id: 521045:KOLE_RS04475
uniprot id: C5CGL3
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

521045:KOLE RS08390
gene id: 521045:KOLE_RS08390
uniprot id: C5CFD9
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

521045:KOLE RS00540
gene id: 521045:KOLE_RS00540
uniprot id: C5CHX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

521045:KOLE RS07930
gene id: 521045:KOLE_RS07930
uniprot id: C5CET3
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

521045:KOLE RS10250
gene id: 521045:KOLE_RS10250
uniprot id: C5CHN2
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

521045:KOLE RS02225
gene id: 521045:KOLE_RS02225
uniprot id: C5CE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

521045:KOLE RS00530
gene id: 521045:KOLE_RS00530
uniprot id: C5CHX6
names: Similarity
messages: Belongs to the aspartokinase family.

521045:KOLE RS09465
gene id: 521045:KOLE_RS09465
uniprot id: C5CGH3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

521045:KOLE RS01140
gene id: 521045:KOLE_RS01140
uniprot id: C5CIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

521045:KOLE RS01640
gene id: 521045:KOLE_RS01640
uniprot id: C5CDG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

521045:KOLE RS03525
gene id: 521045:KOLE_RS03525
uniprot id: C5CFJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

521045:KOLE RS08375
gene id: 521045:KOLE_RS08375
uniprot id: C5CFD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

521045:KOLE RS00930
gene id: 521045:KOLE_RS00930
uniprot id: C5CIR5
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

521045:KOLE RS08080
gene id: 521045:KOLE_RS08080
uniprot id: C5CF28
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

521045:KOLE RS03780
gene id: 521045:KOLE_RS03780
uniprot id: C5CG17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

521045:KOLE RS08915
gene id: 521045:KOLE_RS08915
uniprot id: C5CFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

521045:KOLE RS05640
gene id: 521045:KOLE_RS05640
uniprot id: C5CI42
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS09445
gene id: 521045:KOLE_RS09445
uniprot id: C5CGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

521045:KOLE RS06060
gene id: 521045:KOLE_RS06060
uniprot id: C5CIY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS10425
gene id: 521045:KOLE_RS10425
uniprot id: C5CHR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

521045:KOLE RS07775
gene id: 521045:KOLE_RS07775
uniprot id: C5CEQ3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

521045:KOLE RS01105
gene id: 521045:KOLE_RS01105
uniprot id: C5CIV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

521045:KOLE RS09590
gene id: 521045:KOLE_RS09590
uniprot id: C5CGR0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

521045:KOLE RS04410
gene id: 521045:KOLE_RS04410
uniprot id: C5CGK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS08620
gene id: 521045:KOLE_RS08620
uniprot id: C5CFP4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

521045:KOLE RS08745
gene id: 521045:KOLE_RS08745
uniprot id: C5CFR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

521045:KOLE RS10255
gene id: 521045:KOLE_RS10255
uniprot id: C5CHN3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

521045:KOLE RS10730
gene id: 521045:KOLE_RS10730
uniprot id: C5CI98
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

521045:KOLE RS09630
gene id: 521045:KOLE_RS09630
uniprot id: C5CGR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

521045:KOLE RS06745
gene id: 521045:KOLE_RS06745
uniprot id: C5CDM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

521045:KOLE RS07665
gene id: 521045:KOLE_RS07665
uniprot id: C5CEN1
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

521045:KOLE RS02370
gene id: 521045:KOLE_RS02370
uniprot id: C5CE78
names: Subcellular Location Annotation
messages: Membrane

521045:KOLE RS07580
gene id: 521045:KOLE_RS07580
uniprot id: C5CEF5
names: Similarity
messages: Belongs to the transposase IS21/IS408/IS1162 family.

521045:KOLE RS01825
gene id: 521045:KOLE_RS01825
uniprot id: C5CDJ6
names: Similarity
messages: Belongs to the GSP E family.

521045:KOLE RS04070
gene id: 521045:KOLE_RS04070
uniprot id: C5CG74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

521045:KOLE RS06500
gene id: 521045:KOLE_RS06500
uniprot id: C5CDC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

521045:KOLE RS10245
gene id: 521045:KOLE_RS10245
uniprot id: C5CHN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

521045:KOLE RS04465
gene id: 521045:KOLE_RS04465
uniprot id: C5CGL1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

521045:KOLE RS00210
gene id: 521045:KOLE_RS00210
uniprot id: C5CHD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

521045:KOLE RS03510
gene id: 521045:KOLE_RS03510
uniprot id: C5CFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

521045:KOLE RS03600
gene id: 521045:KOLE_RS03600
uniprot id: C5CFK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

521045:KOLE RS09350
gene id: 521045:KOLE_RS09350
uniprot id: C5CGF1
names: Similarity
messages: Belongs to the YicC/YloC family.

521045:KOLE RS10700
gene id: 521045:KOLE_RS10700
uniprot id: C5CI92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

521045:KOLE RS09530
gene id: 521045:KOLE_RS09530
uniprot id: C5CGI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

521045:KOLE RS00270
gene id: 521045:KOLE_RS00270
uniprot id: C5CHD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

521045:KOLE RS05485
gene id: 521045:KOLE_RS05485
uniprot id: C5CI11
names: Similarity
messages: Belongs to the AOR/FOR family.

521045:KOLE RS01585
gene id: 521045:KOLE_RS01585
uniprot id: C5CD93
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

521045:KOLE RS04770
gene id: 521045:KOLE_RS04770
uniprot id: C5CGY9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

521045:KOLE RS03790
gene id: 521045:KOLE_RS03790
uniprot id: C5CG19
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

521045:KOLE RS09965
gene id: 521045:KOLE_RS09965
uniprot id: C5CH51
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

521045:KOLE RS10315
gene id: 521045:KOLE_RS10315
uniprot id: C5CHP4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

521045:KOLE RS01370
gene id: 521045:KOLE_RS01370
uniprot id: C5CD50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

521045:KOLE RS01230
gene id: 521045:KOLE_RS01230
uniprot id: C5CIX8
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

521045:KOLE RS05075
gene id: 521045:KOLE_RS05075
uniprot id: C5CHF7
names: Similarity
messages: Belongs to the peptidase U62 family.

521045:KOLE RS05285
gene id: 521045:KOLE_RS05285
uniprot id: C5CHJ6
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.