512564:MCRO RS01985
gene id: 512564:MCRO_RS01985
uniprot id: D5E5H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

512564:MCRO RS02255
gene id: 512564:MCRO_RS02255
uniprot id: D5E5M6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

512564:MCRO RS02215
gene id: 512564:MCRO_RS02215
uniprot id: D5E5L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

512564:MCRO RS01145
gene id: 512564:MCRO_RS01145
uniprot id: D5E545
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03005
gene id: 512564:MCRO_RS03005
uniprot id: D5E612
names: Similarity
messages: Belongs to the DprA/Smf family.

512564:MCRO RS00195
gene id: 512564:MCRO_RS00195
uniprot id: D5E4M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

512564:MCRO RS00035
gene id: 512564:MCRO_RS00035
uniprot id: D5E4J8
names: Similarity
messages: Belongs to the peptidase M13 family.

512564:MCRO RS02010
gene id: 512564:MCRO_RS02010
uniprot id: D5E5I3
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

512564:MCRO RS03030
gene id: 512564:MCRO_RS03030
uniprot id: D5E617
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

512564:MCRO RS02630
gene id: 512564:MCRO_RS02630
uniprot id: D5E5U1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

512564:MCRO RS02595
gene id: 512564:MCRO_RS02595
uniprot id: D5E5T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS01380
gene id: 512564:MCRO_RS01380
uniprot id: D5E586
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

512564:MCRO RS02000
gene id: 512564:MCRO_RS02000
uniprot id: D5E5I1
names: Similarity
messages: Belongs to the polysaccharide lyase 8 family.

512564:MCRO RS01040
gene id: 512564:MCRO_RS01040
uniprot id: D5E525
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

512564:MCRO RS00835
gene id: 512564:MCRO_RS00835
uniprot id: D5E501
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

512564:MCRO RS02220
gene id: 512564:MCRO_RS02220
uniprot id: D5E5L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

512564:MCRO RS00165
gene id: 512564:MCRO_RS00165
uniprot id: D5E4M3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

512564:MCRO RS03425
gene id: 512564:MCRO_RS03425
uniprot id: D5E682
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03525
gene id: 512564:MCRO_RS03525
uniprot id: D5E699
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

512564:MCRO RS02315
gene id: 512564:MCRO_RS02315
uniprot id: D5E5N5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

512564:MCRO RS01275
gene id: 512564:MCRO_RS01275
uniprot id: D5E565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS00130
gene id: 512564:MCRO_RS00130
uniprot id: D5E4L7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS02145
gene id: 512564:MCRO_RS02145
uniprot id: D5E5K8
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS03645
gene id: 512564:MCRO_RS03645
uniprot id: D5E6C2
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

512564:MCRO RS03530
gene id: 512564:MCRO_RS03530
uniprot id: D5E6A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

512564:MCRO RS00745
gene id: 512564:MCRO_RS00745
uniprot id: D5E4Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

512564:MCRO RS00515
gene id: 512564:MCRO_RS00515
uniprot id: D5E4T7
names: Similarity
messages: Belongs to the ATPase gamma chain family.

512564:MCRO RS00105
gene id: 512564:MCRO_RS00105
uniprot id: D5E4L2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

512564:MCRO RS02695
gene id: 512564:MCRO_RS02695
uniprot id: D5E5V3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

512564:MCRO RS00870
gene id: 512564:MCRO_RS00870
uniprot id: D5E503
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02040
gene id: 512564:MCRO_RS02040
uniprot id: D5E5I8
names: Subcellular Location Annotation
messages: Cytoplasm

512564:MCRO RS01320
gene id: 512564:MCRO_RS01320
uniprot id: D5E574
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

512564:MCRO RS03995
gene id: 512564:MCRO_RS03995
uniprot id: D5E646
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

512564:MCRO RS02605
gene id: 512564:MCRO_RS02605
uniprot id: D5E5T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

512564:MCRO RS01010
gene id: 512564:MCRO_RS01010
uniprot id: D5E519
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS03025
gene id: 512564:MCRO_RS03025
uniprot id: D5E616
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

512564:MCRO RS03335
gene id: 512564:MCRO_RS03335
uniprot id: D5E666
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

512564:MCRO RS03630
gene id: 512564:MCRO_RS03630
uniprot id: B8XTQ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

512564:MCRO RS01875
gene id: 512564:MCRO_RS01875
uniprot id: D5E5G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

512564:MCRO RS01090
gene id: 512564:MCRO_RS01090
uniprot id: D5E535
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

512564:MCRO RS00090
gene id: 512564:MCRO_RS00090
uniprot id: D5E4K9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

512564:MCRO RS00315
gene id: 512564:MCRO_RS00315
uniprot id: D5E4Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

512564:MCRO RS02555
gene id: 512564:MCRO_RS02555
uniprot id: D5E5S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS01210
gene id: 512564:MCRO_RS01210
uniprot id: D5E553
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

512564:MCRO RS01155
gene id: 512564:MCRO_RS01155
uniprot id: D5E546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

512564:MCRO RS02860
gene id: 512564:MCRO_RS02860
uniprot id: D5E5Y5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

512564:MCRO RS02190
gene id: 512564:MCRO_RS02190
uniprot id: D5E5L3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

512564:MCRO RS02490
gene id: 512564:MCRO_RS02490
uniprot id: D5E5R5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS02675
gene id: 512564:MCRO_RS02675
uniprot id: D5E5V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

512564:MCRO RS00545
gene id: 512564:MCRO_RS00545
uniprot id: D5E4U3
names: Similarity
messages: Belongs to the peptidase M17 family.

512564:MCRO RS02535
gene id: 512564:MCRO_RS02535
uniprot id: D5E5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

512564:MCRO RS00440
gene id: 512564:MCRO_RS00440
uniprot id: D5E4S3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

512564:MCRO RS02325
gene id: 512564:MCRO_RS02325
uniprot id: D5E5N7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

512564:MCRO RS03710
gene id: 512564:MCRO_RS03710
uniprot id: D5E6D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

512564:MCRO RS00765
gene id: 512564:MCRO_RS00765
uniprot id: D5E4Y6
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

512564:MCRO RS02300
gene id: 512564:MCRO_RS02300
uniprot id: D5E5N3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS02295
gene id: 512564:MCRO_RS02295
uniprot id: D5E5N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

512564:MCRO RS02615
gene id: 512564:MCRO_RS02615
uniprot id: D5E5T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

512564:MCRO RS03130
gene id: 512564:MCRO_RS03130
uniprot id: D5E631
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

512564:MCRO RS03290
gene id: 512564:MCRO_RS03290
uniprot id: D5E658
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

512564:MCRO RS02250
gene id: 512564:MCRO_RS02250
uniprot id: D5E5M5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

512564:MCRO RS02890
gene id: 512564:MCRO_RS02890
uniprot id: D5E5Z1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

512564:MCRO RS03060
gene id: 512564:MCRO_RS03060
uniprot id: D5E623
names: Subunit
messages: Monomer.

512564:MCRO RS00670
gene id: 512564:MCRO_RS00670
uniprot id: D5E4W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

512564:MCRO RS00500
gene id: 512564:MCRO_RS00500
uniprot id: D5E4T4
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

512564:MCRO RS01355
gene id: 512564:MCRO_RS01355
uniprot id: D5E581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS02245
gene id: 512564:MCRO_RS02245
uniprot id: D5E5M4
names: Subcellular Location Annotation
messages: Cell membrane

512564:MCRO RS00800
gene id: 512564:MCRO_RS00800
uniprot id: D5E4Z4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

512564:MCRO RS01515
gene id: 512564:MCRO_RS01515
uniprot id: D5E5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

512564:MCRO RS03185
gene id: 512564:MCRO_RS03185
uniprot id: D5E640
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS01440
gene id: 512564:MCRO_RS01440
uniprot id: D5E597
names: Subcellular Location Annotation
messages: Cytoplasm

512564:MCRO RS00655
gene id: 512564:MCRO_RS00655
uniprot id: D5E4W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

512564:MCRO RS00085
gene id: 512564:MCRO_RS00085
uniprot id: D5E4K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS03155
gene id: 512564:MCRO_RS03155
uniprot id: D5E635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS01865
gene id: 512564:MCRO_RS01865
uniprot id: D5E5F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

512564:MCRO RS01060
gene id: 512564:MCRO_RS01060
uniprot id: D5E529
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

512564:MCRO RS01560
gene id: 512564:MCRO_RS01560
uniprot id: D5E5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

512564:MCRO RS03190
gene id: 512564:MCRO_RS03190
uniprot id: D5E641
names: Similarity
messages: Belongs to the carbamate kinase family.

512564:MCRO RS01335
gene id: 512564:MCRO_RS01335
uniprot id: D5E577
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS00070
gene id: 512564:MCRO_RS00070
uniprot id: D5E4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

512564:MCRO RS00445
gene id: 512564:MCRO_RS00445
uniprot id: D5E4S4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

512564:MCRO RS03835
gene id: 512564:MCRO_RS03835
uniprot id: D5E6F8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

512564:MCRO RS00495
gene id: 512564:MCRO_RS00495
uniprot id: D5E4T3
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

512564:MCRO RS00025
gene id: 512564:MCRO_RS00025
uniprot id: D5E4J6
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS00080
gene id: 512564:MCRO_RS00080
uniprot id: D5E4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

512564:MCRO RS01070
gene id: 512564:MCRO_RS01070
uniprot id: D5E531
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

512564:MCRO RS01300
gene id: 512564:MCRO_RS01300
uniprot id: D5E570
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

512564:MCRO RS01530
gene id: 512564:MCRO_RS01530
uniprot id: D5E5B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

512564:MCRO RS01315
gene id: 512564:MCRO_RS01315
uniprot id: D5E573
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

512564:MCRO RS01885
gene id: 512564:MCRO_RS01885
uniprot id: D5E5G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

512564:MCRO RS01310
gene id: 512564:MCRO_RS01310
uniprot id: D5E572
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

512564:MCRO RS02975
gene id: 512564:MCRO_RS02975
uniprot id: D5E606
names: Similarity
messages: Belongs to the transketolase family.

512564:MCRO RS01750
gene id: 512564:MCRO_RS01750
uniprot id: D5E5E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

512564:MCRO RS03240
gene id: 512564:MCRO_RS03240
uniprot id: D5E649
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

512564:MCRO RS01690
gene id: 512564:MCRO_RS01690
uniprot id: D5E5D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

512564:MCRO RS00560
gene id: 512564:MCRO_RS00560
uniprot id: D5E4U6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

512564:MCRO RS01965
gene id: 512564:MCRO_RS01965
uniprot id: D5E5H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS03300
gene id: 512564:MCRO_RS03300
uniprot id: D5E660
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

512564:MCRO RS01290
gene id: 512564:MCRO_RS01290
uniprot id: D5E568
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

512564:MCRO RS02775
gene id: 512564:MCRO_RS02775
uniprot id: D5E5W8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

512564:MCRO RS01215
gene id: 512564:MCRO_RS01215
uniprot id: D5E554
names: Subcellular Location Annotation
messages: cytosol

512564:MCRO RS03200
gene id: 512564:MCRO_RS03200
uniprot id: D5E643
names: Similarity
messages: Belongs to the arginine deiminase family.

512564:MCRO RS02905
gene id: 512564:MCRO_RS02905
uniprot id: D5E5Z4
names: Similarity
messages: Belongs to the XFP family.

512564:MCRO RS03355
gene id: 512564:MCRO_RS03355
uniprot id: D5E670
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

512564:MCRO RS04215
gene id: 512564:MCRO_RS04215
uniprot id: D5E4M0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

512564:MCRO RS03755
gene id: 512564:MCRO_RS03755
uniprot id: D5E6E5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

512564:MCRO RS03310
gene id: 512564:MCRO_RS03310
uniprot id: D5E662
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

512564:MCRO RS01835
gene id: 512564:MCRO_RS01835
uniprot id: D5E5F5
names: Similarity
messages: Belongs to the NusB family.

512564:MCRO RS01055
gene id: 512564:MCRO_RS01055
uniprot id: D5E528
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

512564:MCRO RS00175
gene id: 512564:MCRO_RS00175
uniprot id: D5E4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

512564:MCRO RS00740
gene id: 512564:MCRO_RS00740
uniprot id: D5E4Y1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

512564:MCRO RS02320
gene id: 512564:MCRO_RS02320
uniprot id: D5E5N6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

512564:MCRO RS02625
gene id: 512564:MCRO_RS02625
uniprot id: D5E5U0
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02710
gene id: 512564:MCRO_RS02710
uniprot id: D5E5V6
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

512564:MCRO RS02865
gene id: 512564:MCRO_RS02865
uniprot id: D5E5Y6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

512564:MCRO RS03360
gene id: 512564:MCRO_RS03360
uniprot id: D5E671
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

512564:MCRO RS01165
gene id: 512564:MCRO_RS01165
uniprot id: D5E548
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS03605
gene id: 512564:MCRO_RS03605
uniprot id: D5E6B5
names: Similarity
messages: Belongs to the MG185/MG260 family.

512564:MCRO RS00010
gene id: 512564:MCRO_RS00010
uniprot id: D5E4J3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

512564:MCRO RS00120
gene id: 512564:MCRO_RS00120
uniprot id: D5E4L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

512564:MCRO RS01685
gene id: 512564:MCRO_RS01685
uniprot id: D5E5D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

512564:MCRO RS01205
gene id: 512564:MCRO_RS01205
uniprot id: D5E552
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

512564:MCRO RS00285
gene id: 512564:MCRO_RS00285
uniprot id: D5E4P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

512564:MCRO RS03685
gene id: 512564:MCRO_RS03685
uniprot id: D5E6D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS03665
gene id: 512564:MCRO_RS03665
uniprot id: D5E6C6
names: Similarity
messages: Belongs to the Dps family.

512564:MCRO RS01980
gene id: 512564:MCRO_RS01980
uniprot id: D5E5H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

512564:MCRO RS02705
gene id: 512564:MCRO_RS02705
uniprot id: D5E5V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

512564:MCRO RS00735
gene id: 512564:MCRO_RS00735
uniprot id: D5E4Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

512564:MCRO RS01555
gene id: 512564:MCRO_RS01555
uniprot id: D5E5B6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

512564:MCRO RS03860
gene id: 512564:MCRO_RS03860
uniprot id: D5E6G3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03065
gene id: 512564:MCRO_RS03065
uniprot id: D5E625
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02600
gene id: 512564:MCRO_RS02600
uniprot id: D5E5T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS00775
gene id: 512564:MCRO_RS00775
uniprot id: D5E4Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

512564:MCRO RS00660
gene id: 512564:MCRO_RS00660
uniprot id: D5E4W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

512564:MCRO RS00640
gene id: 512564:MCRO_RS00640
uniprot id: D5E4W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

512564:MCRO RS03440
gene id: 512564:MCRO_RS03440
uniprot id: D5E683
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS03905
gene id: 512564:MCRO_RS03905
uniprot id: D5E6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

512564:MCRO RS01715
gene id: 512564:MCRO_RS01715
uniprot id: D5E5D5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

512564:MCRO RS01860
gene id: 512564:MCRO_RS01860
uniprot id: D5E5F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

512564:MCRO RS02935
gene id: 512564:MCRO_RS02935
uniprot id: D5E5Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

512564:MCRO RS00825
gene id: 512564:MCRO_RS00825
uniprot id: D5E4Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

512564:MCRO RS03075
gene id: 512564:MCRO_RS03075
uniprot id: D5E627
names: Cofactor
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

512564:MCRO RS02765
gene id: 512564:MCRO_RS02765
uniprot id: D5E5W6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

512564:MCRO RS03305
gene id: 512564:MCRO_RS03305
uniprot id: D5E661
names: Similarity
messages: Belongs to the HPrK/P family.

512564:MCRO RS03420
gene id: 512564:MCRO_RS03420
uniprot id: D5E681
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

512564:MCRO RS03010
gene id: 512564:MCRO_RS03010
uniprot id: D5E613
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

512564:MCRO RS03850
gene id: 512564:MCRO_RS03850
uniprot id: D5E6G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

512564:MCRO RS03475
gene id: 512564:MCRO_RS03475
uniprot id: D5E689
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

512564:MCRO RS03345
gene id: 512564:MCRO_RS03345
uniprot id: D5E668
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

512564:MCRO RS00470
gene id: 512564:MCRO_RS00470
uniprot id: D5E4T0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

512564:MCRO RS01075
gene id: 512564:MCRO_RS01075
uniprot id: D5E532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

512564:MCRO RS01960
gene id: 512564:MCRO_RS01960
uniprot id: D5E5H4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS00770
gene id: 512564:MCRO_RS00770
uniprot id: D5E4Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

512564:MCRO RS01110
gene id: 512564:MCRO_RS01110
uniprot id: D5E539
names: Similarity
messages: Belongs to the DDAH family.

512564:MCRO RS03245
gene id: 512564:MCRO_RS03245
uniprot id: D5E650
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

512564:MCRO RS00055
gene id: 512564:MCRO_RS00055
uniprot id: D5E4K2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

512564:MCRO RS00750
gene id: 512564:MCRO_RS00750
uniprot id: D5E4Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

512564:MCRO RS03830
gene id: 512564:MCRO_RS03830
uniprot id: D5E6F7
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

512564:MCRO RS02785
gene id: 512564:MCRO_RS02785
uniprot id: D5E5X0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03275
gene id: 512564:MCRO_RS03275
uniprot id: D5E655
names: Similarity
messages: Belongs to the IMPACT family.

512564:MCRO RS03700
gene id: 512564:MCRO_RS03700
uniprot id: D5E6D4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

512564:MCRO RS02870
gene id: 512564:MCRO_RS02870
uniprot id: D5E5Y7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

512564:MCRO RS00885
gene id: 512564:MCRO_RS00885
uniprot id: D5E506
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02825
gene id: 512564:MCRO_RS02825
uniprot id: D5E5X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

512564:MCRO RS01425
gene id: 512564:MCRO_RS01425
uniprot id: D5E594
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

512564:MCRO RS02995
gene id: 512564:MCRO_RS02995
uniprot id: D5E610
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

512564:MCRO RS02950
gene id: 512564:MCRO_RS02950
uniprot id: D5E602
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS03805
gene id: 512564:MCRO_RS03805
uniprot id: D5E6F3
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

512564:MCRO RS04005
gene id: 512564:MCRO_RS04005
uniprot id: D5E6E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

512564:MCRO RS00945
gene id: 512564:MCRO_RS00945
uniprot id: D5E509
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

512564:MCRO RS01130
gene id: 512564:MCRO_RS01130
uniprot id: D5E542
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02205
gene id: 512564:MCRO_RS02205
uniprot id: D5E5L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

512564:MCRO RS00060
gene id: 512564:MCRO_RS00060
uniprot id: D5E4K3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

512564:MCRO RS03210
gene id: 512564:MCRO_RS03210
uniprot id: D5E644
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

512564:MCRO RS00605
gene id: 512564:MCRO_RS00605
uniprot id: D5E4V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

512564:MCRO RS01140
gene id: 512564:MCRO_RS01140
uniprot id: D5E544
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS00950
gene id: 512564:MCRO_RS00950
uniprot id: D5E510
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

512564:MCRO RS03810
gene id: 512564:MCRO_RS03810
uniprot id: D5E6F4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

512564:MCRO RS00355
gene id: 512564:MCRO_RS00355
uniprot id: D5E4Q9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

512564:MCRO RS00100
gene id: 512564:MCRO_RS00100
uniprot id: D5E4L1
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS03590
gene id: 512564:MCRO_RS03590
uniprot id: D5E6B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS01870
gene id: 512564:MCRO_RS01870
uniprot id: D5E5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

512564:MCRO RS03720
gene id: 512564:MCRO_RS03720
uniprot id: D5E6D8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

512564:MCRO RS00465
gene id: 512564:MCRO_RS00465
uniprot id: D5E4S8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

512564:MCRO RS02810
gene id: 512564:MCRO_RS02810
uniprot id: D5E5X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

512564:MCRO RS02330
gene id: 512564:MCRO_RS02330
uniprot id: D5E5N8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

512564:MCRO RS00610
gene id: 512564:MCRO_RS00610
uniprot id: D5E4V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

512564:MCRO RS02110
gene id: 512564:MCRO_RS02110
uniprot id: D5E5K2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

512564:MCRO RS03150
gene id: 512564:MCRO_RS03150
uniprot id: D5E634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS00635
gene id: 512564:MCRO_RS00635
uniprot id: D5E4W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

512564:MCRO RS03725
gene id: 512564:MCRO_RS03725
uniprot id: D5E6D9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

512564:MCRO RS00755
gene id: 512564:MCRO_RS00755
uniprot id: D5E4Y4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

512564:MCRO RS01015
gene id: 512564:MCRO_RS01015
uniprot id: D5E520
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

512564:MCRO RS00690
gene id: 512564:MCRO_RS00690
uniprot id: D5E4X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

512564:MCRO RS02445
gene id: 512564:MCRO_RS02445
uniprot id: D5E5Q7
names: Similarity
messages: Belongs to the DprA/Smf family.

512564:MCRO RS00680
gene id: 512564:MCRO_RS00680
uniprot id: D5E4X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

512564:MCRO RS00215
gene id: 512564:MCRO_RS00215
uniprot id: D5E4N3
names: Similarity
messages: Belongs to the CTP synthase family.

512564:MCRO RS01360
gene id: 512564:MCRO_RS01360
uniprot id: D5E582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS03250
gene id: 512564:MCRO_RS03250
uniprot id: D5E651
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

512564:MCRO RS00540
gene id: 512564:MCRO_RS00540
uniprot id: D5E4U2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS01940
gene id: 512564:MCRO_RS01940
uniprot id: D5E5H2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS02965
gene id: 512564:MCRO_RS02965
uniprot id: D5E604
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

512564:MCRO RS01895
gene id: 512564:MCRO_RS01895
uniprot id: D5E5G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

512564:MCRO RS03485
gene id: 512564:MCRO_RS03485
uniprot id: D5E691
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

512564:MCRO RS01265
gene id: 512564:MCRO_RS01265
uniprot id: D5E563
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS00625
gene id: 512564:MCRO_RS00625
uniprot id: D5E4V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

512564:MCRO RS03845
gene id: 512564:MCRO_RS03845
uniprot id: D5E6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

512564:MCRO RS01045
gene id: 512564:MCRO_RS01045
uniprot id: D5E526
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

512564:MCRO RS01420
gene id: 512564:MCRO_RS01420
uniprot id: D5E593
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS01125
gene id: 512564:MCRO_RS01125
uniprot id: D5E541
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

512564:MCRO RS01775
gene id: 512564:MCRO_RS01775
uniprot id: D5E5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

512564:MCRO RS02035
gene id: 512564:MCRO_RS02035
uniprot id: D5E5I7
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS01200
gene id: 512564:MCRO_RS01200
uniprot id: D5E551
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

512564:MCRO RS02940
gene id: 512564:MCRO_RS02940
uniprot id: D5E600
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

512564:MCRO RS03015
gene id: 512564:MCRO_RS03015
uniprot id: D5E614
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

512564:MCRO RS00695
gene id: 512564:MCRO_RS00695
uniprot id: D5E4X3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

512564:MCRO RS02970
gene id: 512564:MCRO_RS02970
uniprot id: D5E605
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

512564:MCRO RS00280
gene id: 512564:MCRO_RS00280
uniprot id: D5E4P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

512564:MCRO RS02685
gene id: 512564:MCRO_RS02685
uniprot id: D5E5V1
names: Similarity
messages: Belongs to the pyruvate kinase family.

512564:MCRO RS02820
gene id: 512564:MCRO_RS02820
uniprot id: D5E5X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

512564:MCRO RS00630
gene id: 512564:MCRO_RS00630
uniprot id: D5E4W0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

512564:MCRO RS00650
gene id: 512564:MCRO_RS00650
uniprot id: D5E4W4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

512564:MCRO RS01770
gene id: 512564:MCRO_RS01770
uniprot id: D5E5E3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

512564:MCRO RS01795
gene id: 512564:MCRO_RS01795
uniprot id: D5E5E7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

512564:MCRO RS02990
gene id: 512564:MCRO_RS02990
uniprot id: D5E609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

512564:MCRO RS01345
gene id: 512564:MCRO_RS01345
uniprot id: D5E579
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03680
gene id: 512564:MCRO_RS03680
uniprot id: D5E6C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS00795
gene id: 512564:MCRO_RS00795
uniprot id: D5E4Z3
names: Caution
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS00045
gene id: 512564:MCRO_RS00045
uniprot id: D5E4K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

512564:MCRO RS02790
gene id: 512564:MCRO_RS02790
uniprot id: D5E5X1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

512564:MCRO RS03325
gene id: 512564:MCRO_RS03325
uniprot id: D5E664
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

512564:MCRO RS02200
gene id: 512564:MCRO_RS02200
uniprot id: D5E5L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

512564:MCRO RS01105
gene id: 512564:MCRO_RS01105
uniprot id: D5E538
names: Similarity
messages: Belongs to the peptidase S16 family.

512564:MCRO RS01350
gene id: 512564:MCRO_RS01350
uniprot id: D5E580
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

512564:MCRO RS00430
gene id: 512564:MCRO_RS00430
uniprot id: D5E4S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

512564:MCRO RS02885
gene id: 512564:MCRO_RS02885
uniprot id: D5E5Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

512564:MCRO RS00245
gene id: 512564:MCRO_RS00245
uniprot id: D5E4N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS03940
gene id: 512564:MCRO_RS03940
uniprot id: D5E6H7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

512564:MCRO RS03165
gene id: 512564:MCRO_RS03165
uniprot id: D5E637
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

512564:MCRO RS00730
gene id: 512564:MCRO_RS00730
uniprot id: D5E4X9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

512564:MCRO RS03950
gene id: 512564:MCRO_RS03950
uniprot id: D5E6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

512564:MCRO RS03040
gene id: 512564:MCRO_RS03040
uniprot id: D5E619
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

512564:MCRO RS00030
gene id: 512564:MCRO_RS00030
uniprot id: D5E4J7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS00700
gene id: 512564:MCRO_RS00700
uniprot id: D5E4X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

512564:MCRO RS03370
gene id: 512564:MCRO_RS03370
uniprot id: D5E672
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

512564:MCRO RS01800
gene id: 512564:MCRO_RS01800
uniprot id: D5E5E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

512564:MCRO RS00675
gene id: 512564:MCRO_RS00675
uniprot id: D5E4W9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

512564:MCRO RS02195
gene id: 512564:MCRO_RS02195
uniprot id: D5E5L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

512564:MCRO RS03390
gene id: 512564:MCRO_RS03390
uniprot id: D5E675
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

512564:MCRO RS03815
gene id: 512564:MCRO_RS03815
uniprot id: D5E6F5
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

512564:MCRO RS03915
gene id: 512564:MCRO_RS03915
uniprot id: D5E6H3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03570
gene id: 512564:MCRO_RS03570
uniprot id: D5E6A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

512564:MCRO RS03270
gene id: 512564:MCRO_RS03270
uniprot id: D5E654
names: Similarity
messages: Belongs to the peptidase M17 family.

512564:MCRO RS03855
gene id: 512564:MCRO_RS03855
uniprot id: D5E6G2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

512564:MCRO RS01880
gene id: 512564:MCRO_RS01880
uniprot id: D5E5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

512564:MCRO RS01100
gene id: 512564:MCRO_RS01100
uniprot id: D5E537
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

512564:MCRO RS01815
gene id: 512564:MCRO_RS01815
uniprot id: D5E5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

512564:MCRO RS00530
gene id: 512564:MCRO_RS00530
uniprot id: D5E4U0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

512564:MCRO RS01245
gene id: 512564:MCRO_RS01245
uniprot id: D5E560
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

512564:MCRO RS03820
gene id: 512564:MCRO_RS03820
uniprot id: D5E6F6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS03535
gene id: 512564:MCRO_RS03535
uniprot id: D5E6A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

512564:MCRO RS03945
gene id: 512564:MCRO_RS03945
uniprot id: D5E6H8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

512564:MCRO RS02095
gene id: 512564:MCRO_RS02095
uniprot id: D5E5J9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

512564:MCRO RS00490
gene id: 512564:MCRO_RS00490
uniprot id: D5E4T2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

512564:MCRO RS00350
gene id: 512564:MCRO_RS00350
uniprot id: D5E4Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

512564:MCRO RS03980
gene id: 512564:MCRO_RS03980
uniprot id: D5E584
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

512564:MCRO RS00290
gene id: 512564:MCRO_RS00290
uniprot id: D5E4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

512564:MCRO RS01825
gene id: 512564:MCRO_RS01825
uniprot id: D5E5F3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

512564:MCRO RS03625
gene id: 512564:MCRO_RS03625
uniprot id: A7UN08
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

512564:MCRO RS00760
gene id: 512564:MCRO_RS00760
uniprot id: D5E4Y5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

512564:MCRO RS00685
gene id: 512564:MCRO_RS00685
uniprot id: D5E4X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

512564:MCRO RS03555
gene id: 512564:MCRO_RS03555
uniprot id: D5E6A5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

512564:MCRO RS00645
gene id: 512564:MCRO_RS00645
uniprot id: D5E4W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

512564:MCRO RS00955
gene id: 512564:MCRO_RS00955
uniprot id: D5E511
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

512564:MCRO RS00365
gene id: 512564:MCRO_RS00365
uniprot id: D5E4R1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

512564:MCRO RS00210
gene id: 512564:MCRO_RS00210
uniprot id: D5E4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

512564:MCRO RS03505
gene id: 512564:MCRO_RS03505
uniprot id: D5E695
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

512564:MCRO RS00615
gene id: 512564:MCRO_RS00615
uniprot id: D5E4V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

512564:MCRO RS02770
gene id: 512564:MCRO_RS02770
uniprot id: D5E5W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

512564:MCRO RS01280
gene id: 512564:MCRO_RS01280
uniprot id: D5E566
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

512564:MCRO RS01615
gene id: 512564:MCRO_RS01615
uniprot id: D5E5C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

512564:MCRO RS01550
gene id: 512564:MCRO_RS01550
uniprot id: D5E5B5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS02455
gene id: 512564:MCRO_RS02455
uniprot id: D5E5Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS00555
gene id: 512564:MCRO_RS00555
uniprot id: D5E4U5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

512564:MCRO RS01085
gene id: 512564:MCRO_RS01085
uniprot id: D5E534
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS01050
gene id: 512564:MCRO_RS01050
uniprot id: D5E527
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

512564:MCRO RS01910
gene id: 512564:MCRO_RS01910
uniprot id: D5E5G8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

512564:MCRO RS00575
gene id: 512564:MCRO_RS00575
uniprot id: D5E4U8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

512564:MCRO RS03195
gene id: 512564:MCRO_RS03195
uniprot id: D5E642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

512564:MCRO RS03255
gene id: 512564:MCRO_RS03255
uniprot id: D5E652
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

512564:MCRO RS00620
gene id: 512564:MCRO_RS00620
uniprot id: D5E4V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

512564:MCRO RS03175
gene id: 512564:MCRO_RS03175
uniprot id: D5E638
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

512564:MCRO RS01500
gene id: 512564:MCRO_RS01500
uniprot id: D5E5A5
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

512564:MCRO RS03650
gene id: 512564:MCRO_RS03650
uniprot id: D5E6C3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

512564:MCRO RS03575
gene id: 512564:MCRO_RS03575
uniprot id: D5E6A9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

512564:MCRO RS03585
gene id: 512564:MCRO_RS03585
uniprot id: D5E6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS01180
gene id: 512564:MCRO_RS01180
uniprot id: D5E549
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

512564:MCRO RS01025
gene id: 512564:MCRO_RS01025
uniprot id: D5E522
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

512564:MCRO RS03865
gene id: 512564:MCRO_RS03865
uniprot id: D5E6G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphohexose mutase family.
messages: Membrane

512564:MCRO RS02910
gene id: 512564:MCRO_RS02910
uniprot id: D5E5Z5
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

512564:MCRO RS03375
gene id: 512564:MCRO_RS03375
uniprot id: D5E673
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

512564:MCRO RS01540
gene id: 512564:MCRO_RS01540
uniprot id: D5E5B3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

512564:MCRO RS02230
gene id: 512564:MCRO_RS02230
uniprot id: D5E5M1
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

512564:MCRO RS03925
gene id: 512564:MCRO_RS03925
uniprot id: D5E6H5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

512564:MCRO RS00185
gene id: 512564:MCRO_RS00185
uniprot id: D5E4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

512564:MCRO RS03655
gene id: 512564:MCRO_RS03655
uniprot id: D5E6C4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

512564:MCRO RS01450
gene id: 512564:MCRO_RS01450
uniprot id: D5E598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

512564:MCRO RS00550
gene id: 512564:MCRO_RS00550
uniprot id: D5E4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

512564:MCRO RS03480
gene id: 512564:MCRO_RS03480
uniprot id: D5E690
names: Subcellular Location Annotation
messages: Membrane

512564:MCRO RS02880
gene id: 512564:MCRO_RS02880
uniprot id: D5E5Y9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.