502025:HOCH RS13890
gene id: 502025:HOCH_RS13890
uniprot id: D0LPK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

502025:HOCH RS29745
gene id: 502025:HOCH_RS29745
uniprot id: D0LJV2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS27800
gene id: 502025:HOCH_RS27800
uniprot id: D0LG49
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

502025:HOCH RS19215
gene id: 502025:HOCH_RS19215
uniprot id: D0LZE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

502025:HOCH RS16370
gene id: 502025:HOCH_RS16370
uniprot id: D0LV03
names: Similarity
messages: Belongs to the peptidase U62 family.

502025:HOCH RS28155
gene id: 502025:HOCH_RS28155
uniprot id: D0LGB7
names: Similarity
messages: Belongs to the TrpF family.

502025:HOCH RS29850
gene id: 502025:HOCH_RS29850
uniprot id: D0LJX3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

502025:HOCH RS09620
gene id: 502025:HOCH_RS09620
uniprot id: D0LFR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS00765
gene id: 502025:HOCH_RS00765
uniprot id: D0LGP2
names: Similarity
messages: Belongs to the UPF0758 family.

502025:HOCH RS24955
gene id: 502025:HOCH_RS24955
uniprot id: D0LVG0
names: Similarity
messages: Belongs to the BolA/IbaG family.

502025:HOCH RS23730
gene id: 502025:HOCH_RS23730
uniprot id: D0LSR0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

502025:HOCH RS21575
gene id: 502025:HOCH_RS21575
uniprot id: D0LMF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

502025:HOCH RS00725
gene id: 502025:HOCH_RS00725
uniprot id: D0LGN4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS17645
gene id: 502025:HOCH_RS17645
uniprot id: D0LX56
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS28080
gene id: 502025:HOCH_RS28080
uniprot id: D0LGA2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

502025:HOCH RS41945
gene id: 502025:HOCH_RS41945
uniprot id: D0LT31
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

502025:HOCH RS02560
gene id: 502025:HOCH_RS02560
uniprot id: D0LKB2
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

502025:HOCH RS28370
gene id: 502025:HOCH_RS28370
uniprot id: D0LH40
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

502025:HOCH RS20925
gene id: 502025:HOCH_RS20925
uniprot id: D0LL11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

502025:HOCH RS21580
gene id: 502025:HOCH_RS21580
uniprot id: D0LMF7
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

502025:HOCH RS18510
gene id: 502025:HOCH_RS18510
uniprot id: D0LYB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

502025:HOCH RS08260
gene id: 502025:HOCH_RS08260
uniprot id: D0LX05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

502025:HOCH RS17330
gene id: 502025:HOCH_RS17330
uniprot id: D0LWA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

502025:HOCH RS07685
gene id: 502025:HOCH_RS07685
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS00340
gene id: 502025:HOCH_RS00340
uniprot id: D0LGG2
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS01315
gene id: 502025:HOCH_RS01315
uniprot id: D0LHN6
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

502025:HOCH RS41960
gene id: 502025:HOCH_RS41960
uniprot id: D0LT76
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

502025:HOCH RS22695
gene id: 502025:HOCH_RS22695
uniprot id: D0LQ44
names: Similarity
messages: Belongs to the ParB family.

502025:HOCH RS01155
gene id: 502025:HOCH_RS01155
uniprot id: D0LHK4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.

502025:HOCH RS23120
gene id: 502025:HOCH_RS23120
uniprot id: D0LRD6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

502025:HOCH RS31075
gene id: 502025:HOCH_RS31075
uniprot id: D0LMN4
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

502025:HOCH RS23520
gene id: 502025:HOCH_RS23520
uniprot id: D0LSL9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

502025:HOCH RS23470
gene id: 502025:HOCH_RS23470
uniprot id: D0LSK9
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS33070
gene id: 502025:HOCH_RS33070
uniprot id: D0LSY7
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS08255
gene id: 502025:HOCH_RS08255
uniprot id: D0LX04
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.

502025:HOCH RS25270
gene id: 502025:HOCH_RS25270
uniprot id: D0LVM2
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS11705
gene id: 502025:HOCH_RS11705
uniprot id: D0LJ84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

502025:HOCH RS10435
gene id: 502025:HOCH_RS10435
uniprot id: D0LGV8
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

502025:HOCH RS32995
gene id: 502025:HOCH_RS32995
uniprot id: D0LRW7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS30145
gene id: 502025:HOCH_RS30145
uniprot id: D0LL44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

502025:HOCH RS02150
gene id: 502025:HOCH_RS02150
uniprot id: D0LK31
names: Similarity
messages: Belongs to the heat shock protein 70 family.

502025:HOCH RS00455
gene id: 502025:HOCH_RS00455
uniprot id: D0LGI4
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

502025:HOCH RS19260
gene id: 502025:HOCH_RS19260
uniprot id: D0LZF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

502025:HOCH RS13205
gene id: 502025:HOCH_RS13205
uniprot id: D0LN53
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS18945
gene id: 502025:HOCH_RS18945
uniprot id: D0LZ92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

502025:HOCH RS26510
gene id: 502025:HOCH_RS26510
uniprot id: D0LYF7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

502025:HOCH RS26720
gene id: 502025:HOCH_RS26720
uniprot id: D0LYJ9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS17395
gene id: 502025:HOCH_RS17395
uniprot id: D0LWB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS32035
gene id: 502025:HOCH_RS32035
uniprot id: D0LQA8
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

502025:HOCH RS10730
gene id: 502025:HOCH_RS10730
uniprot id: D0LH15
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

502025:HOCH RS42790
gene id: 502025:HOCH_RS42790
uniprot id: D0LXU4
names: Similarity
messages: In the C-terminal section; belongs to the NRP synthetase family.

502025:HOCH RS28075
gene id: 502025:HOCH_RS28075
uniprot id: D0LGA1
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

502025:HOCH RS00385
gene id: 502025:HOCH_RS00385
uniprot id: D0LGH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

502025:HOCH RS10950
gene id: 502025:HOCH_RS10950
uniprot id: D0LHV1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

502025:HOCH RS34080
gene id: 502025:HOCH_RS34080
uniprot id: D0LUK0
names: Subcellular Location Annotation
messages: Nucleus

502025:HOCH RS19315
gene id: 502025:HOCH_RS19315
uniprot id: D0LI44
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

502025:HOCH RS22530
gene id: 502025:HOCH_RS22530
uniprot id: D0LQ13
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

502025:HOCH RS07775
gene id: 502025:HOCH_RS07775
uniprot id: D0LWQ9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS13470
gene id: 502025:HOCH_RS13470
uniprot id: D0LNA6
names: Similarity
messages: Belongs to the sigma-54 factor family.

502025:HOCH RS19765
gene id: 502025:HOCH_RS19765
uniprot id: D0LJE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

502025:HOCH RS22615
gene id: 502025:HOCH_RS22615
uniprot id: D0LQ28
names: Similarity
messages: Belongs to the P(II) protein family.

502025:HOCH RS29000
gene id: 502025:HOCH_RS29000
uniprot id: D0LIF5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

502025:HOCH RS24455
gene id: 502025:HOCH_RS24455
uniprot id: D0LU60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

502025:HOCH RS28670
gene id: 502025:HOCH_RS28670
uniprot id: D0LHA0
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.

502025:HOCH RS19570
gene id: 502025:HOCH_RS19570
uniprot id: D0LI95
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS22130
gene id: 502025:HOCH_RS22130
uniprot id: D0LNR8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

502025:HOCH RS19435
gene id: 502025:HOCH_RS19435
uniprot id: D0LI68
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS26880
gene id: 502025:HOCH_RS26880
uniprot id: D0LYN1
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

502025:HOCH RS16340
gene id: 502025:HOCH_RS16340
uniprot id: D0LUZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS13280
gene id: 502025:HOCH_RS13280
uniprot id: D0LN68
names: Similarity
messages: Belongs to the peptidase U62 family.

502025:HOCH RS11035
gene id: 502025:HOCH_RS11035
uniprot id: D0LHW9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS22240
gene id: 502025:HOCH_RS22240
uniprot id: D0LPV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

502025:HOCH RS25870
gene id: 502025:HOCH_RS25870
uniprot id: D0LWP7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

502025:HOCH RS30190
gene id: 502025:HOCH_RS30190
uniprot id: D0LL53
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

502025:HOCH RS10680
gene id: 502025:HOCH_RS10680
uniprot id: D0LH05
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

502025:HOCH RS35665
gene id: 502025:HOCH_RS35665
uniprot id: D0LNF8
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

502025:HOCH RS17625
gene id: 502025:HOCH_RS17625
uniprot id: D0LX52
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

502025:HOCH RS23890
gene id: 502025:HOCH_RS23890
uniprot id: D0LSU2
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS42855
gene id: 502025:HOCH_RS42855
uniprot id: D0LW34
names: Similarity
messages: Belongs to the GSP E family.

502025:HOCH RS35960
gene id: 502025:HOCH_RS35960
uniprot id: D0LV78
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09530
gene id: 502025:HOCH_RS09530
uniprot id: D0LZ33
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS08680
gene id: 502025:HOCH_RS08680
uniprot id: D0LXY3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS11535
gene id: 502025:HOCH_RS11535
uniprot id: D0LJ49
names: Similarity
messages: Belongs to the GST superfamily.

502025:HOCH RS26360
gene id: 502025:HOCH_RS26360
uniprot id: D0LXN9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

502025:HOCH RS14840
gene id: 502025:HOCH_RS14840
uniprot id: D0LR33
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

502025:HOCH RS09865
gene id: 502025:HOCH_RS09865
uniprot id: D0LFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS31950
gene id: 502025:HOCH_RS31950
uniprot id: D0LQ91
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

502025:HOCH RS19690
gene id: 502025:HOCH_RS19690
uniprot id: D0LIC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

502025:HOCH RS00245
gene id: 502025:HOCH_RS00245
uniprot id: D0LFQ6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

502025:HOCH RS18515
gene id: 502025:HOCH_RS18515
uniprot id: D0LYB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS00585
gene id: 502025:HOCH_RS00585
uniprot id: D0LGK9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

502025:HOCH RS32665
gene id: 502025:HOCH_RS32665
uniprot id: D0LRQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS01955
gene id: 502025:HOCH_RS01955
uniprot id: D0LIZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

502025:HOCH RS32695
gene id: 502025:HOCH_RS32695
uniprot id: D0LRQ6
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

502025:HOCH RS15040
gene id: 502025:HOCH_RS15040
uniprot id: D0LR71
names: Similarity
messages: Belongs to the group II decarboxylase family.

502025:HOCH RS33785
gene id: 502025:HOCH_RS33785
uniprot id: D0LUE1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

502025:HOCH RS37315
gene id: 502025:HOCH_RS37315
uniprot id: D0LJY4
names: Similarity
messages: Belongs to the FcoT family.

502025:HOCH RS24470
gene id: 502025:HOCH_RS24470
uniprot id: D0LU63
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS19430
gene id: 502025:HOCH_RS19430
uniprot id: D0LI67
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

502025:HOCH RS22645
gene id: 502025:HOCH_RS22645
uniprot id: D0LQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

502025:HOCH RS23860
gene id: 502025:HOCH_RS23860
uniprot id: D0LST6
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS13215
gene id: 502025:HOCH_RS13215
uniprot id: D0LN55
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS25095
gene id: 502025:HOCH_RS25095
uniprot id: D0LVI7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS09110
gene id: 502025:HOCH_RS09110
uniprot id: D0LYV1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

502025:HOCH RS11050
gene id: 502025:HOCH_RS11050
uniprot id: D0LHX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

502025:HOCH RS28040
gene id: 502025:HOCH_RS28040
uniprot id: D0LG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS02700
gene id: 502025:HOCH_RS02700
uniprot id: D0LLF7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS06285
gene id: 502025:HOCH_RS06285
uniprot id: D0LTG8
names: Similarity
messages: Belongs to the group II decarboxylase family.

502025:HOCH RS23940
gene id: 502025:HOCH_RS23940
uniprot id: D0LSV1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24695
gene id: 502025:HOCH_RS24695
uniprot id: D0LVB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

502025:HOCH RS26270
gene id: 502025:HOCH_RS26270
uniprot id: D0LXM1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS41600
gene id: 502025:HOCH_RS41600
uniprot id: D0LNJ6
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

502025:HOCH RS24365
gene id: 502025:HOCH_RS24365
uniprot id: D0LU43
names: Similarity
messages: Belongs to the GARS family.

502025:HOCH RS09780
gene id: 502025:HOCH_RS09780
uniprot id: D0LFV0
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

502025:HOCH RS32490
gene id: 502025:HOCH_RS32490
uniprot id: D0LRL7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

502025:HOCH RS28460
gene id: 502025:HOCH_RS28460
uniprot id: D0LH58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Maintains high levels of reduced glutathione.

502025:HOCH RS20200
gene id: 502025:HOCH_RS20200
uniprot id: D0LJM0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

502025:HOCH RS32775
gene id: 502025:HOCH_RS32775
uniprot id: D0LRS2
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

502025:HOCH RS02570
gene id: 502025:HOCH_RS02570
uniprot id: D0LKB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

502025:HOCH RS16100
gene id: 502025:HOCH_RS16100
uniprot id: D0LTU6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

502025:HOCH RS36370
gene id: 502025:HOCH_RS36370
uniprot id: D0LM80
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS31545
gene id: 502025:HOCH_RS31545
uniprot id: D0LNZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

502025:HOCH RS28215
gene id: 502025:HOCH_RS28215
uniprot id: D0LGC9
names: Similarity
messages: Belongs to the MEMO1 family.

502025:HOCH RS33725
gene id: 502025:HOCH_RS33725
uniprot id: D0LUC9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

502025:HOCH RS26550
gene id: 502025:HOCH_RS26550
uniprot id: D0LYG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

502025:HOCH RS29485
gene id: 502025:HOCH_RS29485
uniprot id: D0LIQ0
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

502025:HOCH RS09165
gene id: 502025:HOCH_RS09165
uniprot id: D0LYW3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

502025:HOCH RS28905
gene id: 502025:HOCH_RS28905
uniprot id: D0LID5
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Absolutely required for BMC formation; when deleted from an artificial operon (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) being expressed in E.coli, no BMC shells are made.
messages: Artificial BMCs can be made in E.coli by expressing (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) or (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)). Cargo proteins can be targeted to this BMC (PubMed:24631000, PubMed:28642439). Artificial BMCs can be made by duplicating this gene with a 16 residue linker between the copies (making an artificial BMC-T). The shell assembles into balls with holes where the pentameric subunit would be, and can be used as a model to study assembly and permeability (PubMed:30901520). Additional changes to this protein place the N- and C-terminii in the interior of the shell (called CPH). Fusing proteins to the C-terminus of CPH allows targeting of cargo proteins to the lumen of the organelle composed of CPH, BMC-P and BMC-T1 (PubMed:31075444).
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.
messages: Homohexamer with a small central pore (PubMed:26617073, PubMed:28642439, PubMed:31075444, PubMed:30833088) (Probable). When purified protein is examined by atomic force microscopy it dynamically makes uniform patches about 35 Angstroms thick with hexamers in the same orientation (PubMed:26617073). In the BMC the concave side faces outward, with the N- and C-terminii exposed to the cytoplasm (PubMed:28642439).
messages: The only hexameric shell protein in this bacterium, it forms the majority of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms a 40 nm artificial BMC with a molecular mass of 6.5 MDa. There are 60 BMC-H hexamers per BMC. The shell facets are 20-30 Angstroms thick (a single hexamer layer), with 1 of BMC-T trimers protruding to the exterior.

502025:HOCH RS24370
gene id: 502025:HOCH_RS24370
uniprot id: D0LU44
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

502025:HOCH RS18730
gene id: 502025:HOCH_RS18730
uniprot id: D0LZ51
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24625
gene id: 502025:HOCH_RS24625
uniprot id: D0LU94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

502025:HOCH RS23885
gene id: 502025:HOCH_RS23885
uniprot id: D0LSU1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09770
gene id: 502025:HOCH_RS09770
uniprot id: D0LFU8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS13225
gene id: 502025:HOCH_RS13225
uniprot id: D0LN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

502025:HOCH RS32830
gene id: 502025:HOCH_RS32830
uniprot id: D0LRT4
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

502025:HOCH RS17345
gene id: 502025:HOCH_RS17345
uniprot id: D0LWA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS34130
gene id: 502025:HOCH_RS34130
uniprot id: D0LUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

502025:HOCH RS05575
gene id: 502025:HOCH_RS05575
uniprot id: D0LS31
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS19160
gene id: 502025:HOCH_RS19160
uniprot id: D0LZD0
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS15345
gene id: 502025:HOCH_RS15345
uniprot id: D0LSE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS06500
gene id: 502025:HOCH_RS06500
uniprot id: D0LTK8
names: Function
messages: Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.

502025:HOCH RS20585
gene id: 502025:HOCH_RS20585
uniprot id: D0LKU5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS26700
gene id: 502025:HOCH_RS26700
uniprot id: D0LYJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

502025:HOCH RS18990
gene id: 502025:HOCH_RS18990
uniprot id: D0LZ99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS09590
gene id: 502025:HOCH_RS09590
uniprot id: D0LFR3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

502025:HOCH RS26920
gene id: 502025:HOCH_RS26920
uniprot id: D0LYN9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

502025:HOCH RS05665
gene id: 502025:HOCH_RS05665
uniprot id: D0LS49
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

502025:HOCH RS07990
gene id: 502025:HOCH_RS07990
uniprot id: D0LWV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS29375
gene id: 502025:HOCH_RS29375
uniprot id: D0LIM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

502025:HOCH RS32735
gene id: 502025:HOCH_RS32735
uniprot id: D0LRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

502025:HOCH RS14350
gene id: 502025:HOCH_RS14350
uniprot id: D0LPT8
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS19725
gene id: 502025:HOCH_RS19725
uniprot id: D0LIC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

502025:HOCH RS13505
gene id: 502025:HOCH_RS13505
uniprot id: D0LNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

502025:HOCH RS16920
gene id: 502025:HOCH_RS16920
uniprot id: D0LW20
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS21945
gene id: 502025:HOCH_RS21945
uniprot id: D0LNN2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

502025:HOCH RS02165
gene id: 502025:HOCH_RS02165
uniprot id: D0LK34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

502025:HOCH RS24545
gene id: 502025:HOCH_RS24545
uniprot id: D0LU78
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

502025:HOCH RS08765
gene id: 502025:HOCH_RS08765
uniprot id: D0LY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS35755
gene id: 502025:HOCH_RS35755
uniprot id: D0LR06
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

502025:HOCH RS33610
gene id: 502025:HOCH_RS33610
uniprot id: D0LUA7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

502025:HOCH RS26695
gene id: 502025:HOCH_RS26695
uniprot id: D0LYJ4
names: Similarity
messages: Belongs to the peptidase C56 family.

502025:HOCH RS21320
gene id: 502025:HOCH_RS21320
uniprot id: D0LMA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

502025:HOCH RS07065
gene id: 502025:HOCH_RS07065
uniprot id: D0LUX8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

502025:HOCH RS33345
gene id: 502025:HOCH_RS33345
uniprot id: D0LT42
names: Similarity
messages: Belongs to the glutamate synthase family.

502025:HOCH RS35285
gene id: 502025:HOCH_RS35285
uniprot id: D0LXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

502025:HOCH RS32245
gene id: 502025:HOCH_RS32245
uniprot id: D0LQE9
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24730
gene id: 502025:HOCH_RS24730
uniprot id: D0LVB7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS19625
gene id: 502025:HOCH_RS19625
uniprot id: D0LIA7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS23900
gene id: 502025:HOCH_RS23900
uniprot id: D0LSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS19640
gene id: 502025:HOCH_RS19640
uniprot id: D0LIB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

502025:HOCH RS42490
gene id: 502025:HOCH_RS42490
uniprot id: D0LYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

502025:HOCH RS34070
gene id: 502025:HOCH_RS34070
uniprot id: D0LUJ8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

502025:HOCH RS16365
gene id: 502025:HOCH_RS16365
uniprot id: D0LV02
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMCs with a molecular mass of 6.5 MDa. One of 2 stacked pseudohexamers in the BMC. There are 20 BMC-T pseudohexamers per BMC, composed of mixed BMC-T1, BMC-T2 and BMC-T3. The shell facets are 20-30 Angstroms thick, with 1 of the stacked BMC-T trimers protruding to the exterior (PubMed:28642439, PubMed:30833088). The stacked trimers may serve as conduits to allow metabolite flux across the protein shell, gated by Arg-68 which contacts Glu-67 in an adjacent subunit; they are flexible enough to play a role in accommodating variations in shell assembly (Probable).
messages: Artificial BMCs can be made in E.coli by expressing (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) or (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)). Cargo proteins can be targeted to this BMC.
messages: Bacterial microcompartment
messages: Belongs to the EutL/PduB family.
messages: Homotrimerizes to form a pseudohexamer. These stack, with the concave faces together, with the concave faces together, in purified bacterial microcompartments (BMC).
messages: Not required for efficient BMC formation; when deleted from an artificial operon (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) being expressed in E.coli, a 2-fold decrease in BMC formation is seen.
messages: These proteins have 2 BMC domains which evolve independently of each other, giving the term pseudohexamer to the trimerized subunit. Although the homotrimer fills the approximate space of a BMC hexamer protein, the BMC-T trimers are more compact. Their universal presence in BMCs indicates their structural importance. The homohexamers form pores of at least 5 Angstroms in diameter; in the stacked homohexamer both pores are closed (PubMed:28642439). In the BMC the inner pore is fully or partially closed while the outer pore is closed (PubMed:30833088).

502025:HOCH RS17075
gene id: 502025:HOCH_RS17075
uniprot id: D0LW51
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

502025:HOCH RS22030
gene id: 502025:HOCH_RS22030
uniprot id: D0LNP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

502025:HOCH RS19830
gene id: 502025:HOCH_RS19830
uniprot id: D0LJE9
names: Similarity
messages: Belongs to the glutamine synthetase family.

502025:HOCH RS08275
gene id: 502025:HOCH_RS08275
uniprot id: D0LX08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

502025:HOCH RS08540
gene id: 502025:HOCH_RS08540
uniprot id: D0LXV5
names: Similarity
messages: Belongs to the TPP enzyme family.

502025:HOCH RS09190
gene id: 502025:HOCH_RS09190
uniprot id: D0LYW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

502025:HOCH RS22090
gene id: 502025:HOCH_RS22090
uniprot id: D0LNR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

502025:HOCH RS03940
gene id: 502025:HOCH_RS03940
uniprot id: D0LP63
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS12895
gene id: 502025:HOCH_RS12895
uniprot id: D0LLZ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS35130
gene id: 502025:HOCH_RS35130
uniprot id: D0LVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS29500
gene id: 502025:HOCH_RS29500
uniprot id: D0LIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS00785
gene id: 502025:HOCH_RS00785
uniprot id: D0LGP6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

502025:HOCH RS07540
gene id: 502025:HOCH_RS07540
uniprot id: D0LVX7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS00535
gene id: 502025:HOCH_RS00535
uniprot id: D0LGK1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

502025:HOCH RS29685
gene id: 502025:HOCH_RS29685
uniprot id: D0LJU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

502025:HOCH RS34015
gene id: 502025:HOCH_RS34015
uniprot id: D0LUI7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

502025:HOCH RS25970
gene id: 502025:HOCH_RS25970
uniprot id: D0LXG1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS22300
gene id: 502025:HOCH_RS22300
uniprot id: D0LPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

502025:HOCH RS01495
gene id: 502025:HOCH_RS01495
uniprot id: D0LIQ5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS22935
gene id: 502025:HOCH_RS22935
uniprot id: D0LRA1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS08990
gene id: 502025:HOCH_RS08990
uniprot id: D0LYS9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS27280
gene id: 502025:HOCH_RS27280
uniprot id: D0LZJ4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS12695
gene id: 502025:HOCH_RS12695
uniprot id: D0LLV4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

502025:HOCH RS16705
gene id: 502025:HOCH_RS16705
uniprot id: D0LV70
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

502025:HOCH RS18470
gene id: 502025:HOCH_RS18470
uniprot id: D0LYB0
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

502025:HOCH RS34125
gene id: 502025:HOCH_RS34125
uniprot id: D0LUK9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

502025:HOCH RS20480
gene id: 502025:HOCH_RS20480
uniprot id: D0LKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

502025:HOCH RS02655
gene id: 502025:HOCH_RS02655
uniprot id: D0LKD1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

502025:HOCH RS13785
gene id: 502025:HOCH_RS13785
uniprot id: D0LPI0
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

502025:HOCH RS30275
gene id: 502025:HOCH_RS30275
uniprot id: D0LL70
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

502025:HOCH RS01525
gene id: 502025:HOCH_RS01525
uniprot id: D0LIR1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09690
gene id: 502025:HOCH_RS09690
uniprot id: D0LFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS36830
gene id: 502025:HOCH_RS36830
uniprot id: D0LWJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

502025:HOCH RS13165
gene id: 502025:HOCH_RS13165
uniprot id: D0LM45
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

502025:HOCH RS30920
gene id: 502025:HOCH_RS30920
uniprot id: D0LMK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS28555
gene id: 502025:HOCH_RS28555
uniprot id: D0LH77
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS00065
gene id: 502025:HOCH_RS00065
uniprot id: D0LFM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

502025:HOCH RS06365
gene id: 502025:HOCH_RS06365
uniprot id: D0LTI3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS22900
gene id: 502025:HOCH_RS22900
uniprot id: D0LR94
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS26855
gene id: 502025:HOCH_RS26855
uniprot id: D0LYM6
names: Similarity
messages: Belongs to the peptidase M1 family.

502025:HOCH RS22215
gene id: 502025:HOCH_RS22215
uniprot id: D0LPV3
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09330
gene id: 502025:HOCH_RS09330
uniprot id: D0LYZ4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS11585
gene id: 502025:HOCH_RS11585
uniprot id: D0LJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

502025:HOCH RS34050
gene id: 502025:HOCH_RS34050
uniprot id: D0LUJ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS32175
gene id: 502025:HOCH_RS32175
uniprot id: D0LQD5
names: Similarity
messages: Belongs to the aspartokinase family.

502025:HOCH RS26865
gene id: 502025:HOCH_RS26865
uniprot id: D0LYM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Membrane

502025:HOCH RS22475
gene id: 502025:HOCH_RS22475
uniprot id: D0LQ04
names: Similarity
messages: Belongs to the Gfa family.

502025:HOCH RS10310
gene id: 502025:HOCH_RS10310
uniprot id: D0LGT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

502025:HOCH RS24860
gene id: 502025:HOCH_RS24860
uniprot id: D0LVE2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

502025:HOCH RS00620
gene id: 502025:HOCH_RS00620
uniprot id: D0LGL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

502025:HOCH RS13275
gene id: 502025:HOCH_RS13275
uniprot id: D0LN67
names: Similarity
messages: Belongs to the peptidase U62 family.

502025:HOCH RS00415
gene id: 502025:HOCH_RS00415
uniprot id: D0LGH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS15415
gene id: 502025:HOCH_RS15415
uniprot id: D0LSF4
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

502025:HOCH RS28095
gene id: 502025:HOCH_RS28095
uniprot id: D0LGA5
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

502025:HOCH RS00330
gene id: 502025:HOCH_RS00330
uniprot id: D0LGG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

502025:HOCH RS07370
gene id: 502025:HOCH_RS07370
uniprot id: D0LVU2
names: Subunit
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

502025:HOCH RS26405
gene id: 502025:HOCH_RS26405
uniprot id: D0LXP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS00010
gene id: 502025:HOCH_RS00010
uniprot id: D0LFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

502025:HOCH RS15645
gene id: 502025:HOCH_RS15645
uniprot id: D0LSJ9
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS02760
gene id: 502025:HOCH_RS02760
uniprot id: D0LLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

502025:HOCH RS09160
gene id: 502025:HOCH_RS09160
uniprot id: D0LYW2
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

502025:HOCH RS09285
gene id: 502025:HOCH_RS09285
uniprot id: D0LYY6
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

502025:HOCH RS17545
gene id: 502025:HOCH_RS17545
uniprot id: D0LX36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

502025:HOCH RS01995
gene id: 502025:HOCH_RS01995
uniprot id: D0LJ04
names: Similarity
messages: Belongs to the heat shock protein 70 family.

502025:HOCH RS08340
gene id: 502025:HOCH_RS08340
uniprot id: D0LX20
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS16155
gene id: 502025:HOCH_RS16155
uniprot id: D0LTV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

502025:HOCH RS06165
gene id: 502025:HOCH_RS06165
uniprot id: D0LTE4
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS12750
gene id: 502025:HOCH_RS12750
uniprot id: D0LLW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Cell membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

502025:HOCH RS22450
gene id: 502025:HOCH_RS22450
uniprot id: D0LPZ9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

502025:HOCH RS16080
gene id: 502025:HOCH_RS16080
uniprot id: D0LTU2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

502025:HOCH RS05615
gene id: 502025:HOCH_RS05615
uniprot id: D0LS39
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS28830
gene id: 502025:HOCH_RS28830
uniprot id: D0LHD1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS30780
gene id: 502025:HOCH_RS30780
uniprot id: D0LMI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

502025:HOCH RS11475
gene id: 502025:HOCH_RS11475
uniprot id: D0LJ37
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS00740
gene id: 502025:HOCH_RS00740
uniprot id: D0LGN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS30740
gene id: 502025:HOCH_RS30740
uniprot id: D0LMH3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

502025:HOCH RS32015
gene id: 502025:HOCH_RS32015
uniprot id: D0LQA4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS12165
gene id: 502025:HOCH_RS12165
uniprot id: D0LKH6
names: Similarity
messages: Belongs to the UPF0102 family.

502025:HOCH RS02550
gene id: 502025:HOCH_RS02550
uniprot id: D0LKB0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

502025:HOCH RS29285
gene id: 502025:HOCH_RS29285
uniprot id: D0LIL1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

502025:HOCH RS08005
gene id: 502025:HOCH_RS08005
uniprot id: D0LWV3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS21360
gene id: 502025:HOCH_RS21360
uniprot id: D0LMB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS19255
gene id: 502025:HOCH_RS19255
uniprot id: D0LZE9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

502025:HOCH RS41310
gene id: 502025:HOCH_RS41310
uniprot id: D0LM31
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

502025:HOCH RS08200
gene id: 502025:HOCH_RS08200
uniprot id: D0LWZ3
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

502025:HOCH RS01490
gene id: 502025:HOCH_RS01490
uniprot id: D0LHS1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS27580
gene id: 502025:HOCH_RS27580
uniprot id: D0LZQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

502025:HOCH RS08985
gene id: 502025:HOCH_RS08985
uniprot id: D0LYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

502025:HOCH RS01750
gene id: 502025:HOCH_RS01750
uniprot id: D0LIV5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS18250
gene id: 502025:HOCH_RS18250
uniprot id: D0LY68
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

502025:HOCH RS33830
gene id: 502025:HOCH_RS33830
uniprot id: D0LUF0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

502025:HOCH RS21350
gene id: 502025:HOCH_RS21350
uniprot id: D0LMB0
names: Similarity
messages: Belongs to the thioesterase family.

502025:HOCH RS02720
gene id: 502025:HOCH_RS02720
uniprot id: D0LLG1
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

502025:HOCH RS31570
gene id: 502025:HOCH_RS31570
uniprot id: D0LNZ5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS19080
gene id: 502025:HOCH_RS19080
uniprot id: D0LZB6
names: Similarity
messages: Belongs to the transketolase family.

502025:HOCH RS18565
gene id: 502025:HOCH_RS18565
uniprot id: D0LYC9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS01295
gene id: 502025:HOCH_RS01295
uniprot id: D0LHN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

502025:HOCH RS12775
gene id: 502025:HOCH_RS12775
uniprot id: D0LLX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS15590
gene id: 502025:HOCH_RS15590
uniprot id: D0LSI8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS02085
gene id: 502025:HOCH_RS02085
uniprot id: D0LJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Belongs to the TonB-dependent receptor family.
messages: Cell inner membrane
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS36690
gene id: 502025:HOCH_RS36690
uniprot id: D0LTY7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

502025:HOCH RS16545
gene id: 502025:HOCH_RS16545
uniprot id: D0LV38
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31615
gene id: 502025:HOCH_RS31615
uniprot id: D0LP04
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

502025:HOCH RS23490
gene id: 502025:HOCH_RS23490
uniprot id: D0LSL3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

502025:HOCH RS00475
gene id: 502025:HOCH_RS00475
uniprot id: D0LGI9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

502025:HOCH RS19365
gene id: 502025:HOCH_RS19365
uniprot id: D0LI54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

502025:HOCH RS29895
gene id: 502025:HOCH_RS29895
uniprot id: D0LJY2
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS24760
gene id: 502025:HOCH_RS24760
uniprot id: D0LVC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

502025:HOCH RS18880
gene id: 502025:HOCH_RS18880
uniprot id: D0LZ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

502025:HOCH RS30480
gene id: 502025:HOCH_RS30480
uniprot id: D0LLB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

502025:HOCH RS29585
gene id: 502025:HOCH_RS29585
uniprot id: D0LJR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

502025:HOCH RS15770
gene id: 502025:HOCH_RS15770
uniprot id: D0LTM9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS26770
gene id: 502025:HOCH_RS26770
uniprot id: D0LYK9
names: Similarity
messages: Belongs to the leucine-binding protein family.

502025:HOCH RS00755
gene id: 502025:HOCH_RS00755
uniprot id: D0LGP0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS28090
gene id: 502025:HOCH_RS28090
uniprot id: D0LGA4
names: Similarity
messages: Belongs to the fabD family.

502025:HOCH RS13210
gene id: 502025:HOCH_RS13210
uniprot id: D0LN54
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS12800
gene id: 502025:HOCH_RS12800
uniprot id: D0LLX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

502025:HOCH RS14675
gene id: 502025:HOCH_RS14675
uniprot id: D0LR02
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22040
gene id: 502025:HOCH_RS22040
uniprot id: D0LNQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS21960
gene id: 502025:HOCH_RS21960
uniprot id: D0LNN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS07960
gene id: 502025:HOCH_RS07960
uniprot id: D0LWU5
names: Similarity
messages: Belongs to the OsmC/Ohr family.

502025:HOCH RS08970
gene id: 502025:HOCH_RS08970
uniprot id: D0LYS5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

502025:HOCH RS00420
gene id: 502025:HOCH_RS00420
uniprot id: D0LGH7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

502025:HOCH RS23905
gene id: 502025:HOCH_RS23905
uniprot id: D0LSU5
names: Similarity
messages: Belongs to the GSP E family.

502025:HOCH RS32655
gene id: 502025:HOCH_RS32655
uniprot id: D0LRP8
names: Similarity
messages: Belongs to the acylphosphatase family.

502025:HOCH RS37085
gene id: 502025:HOCH_RS37085
uniprot id: D0LG54
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22125
gene id: 502025:HOCH_RS22125
uniprot id: D0LNR7
names: Similarity
messages: Belongs to the LuxC family.

502025:HOCH RS16970
gene id: 502025:HOCH_RS16970
uniprot id: D0LW30
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS25105
gene id: 502025:HOCH_RS25105
uniprot id: D0LVI9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS11290
gene id: 502025:HOCH_RS11290
uniprot id: D0LI21
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

502025:HOCH RS03855
gene id: 502025:HOCH_RS03855
uniprot id: D0LN37
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

502025:HOCH RS19035
gene id: 502025:HOCH_RS19035
uniprot id: D0LZA8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS20390
gene id: 502025:HOCH_RS20390
uniprot id: D0LKQ9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS21125
gene id: 502025:HOCH_RS21125
uniprot id: D0LM66
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

502025:HOCH RS23745
gene id: 502025:HOCH_RS23745
uniprot id: D0LSR3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

502025:HOCH RS16015
gene id: 502025:HOCH_RS16015
uniprot id: D0LTS8
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

502025:HOCH RS19305
gene id: 502025:HOCH_RS19305
uniprot id: D0LZF9
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS08755
gene id: 502025:HOCH_RS08755
uniprot id: D0LXZ8
names: Similarity
messages: Belongs to the pirin family.

502025:HOCH RS37765
gene id: 502025:HOCH_RS37765
uniprot id: D0LVP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

502025:HOCH RS17070
gene id: 502025:HOCH_RS17070
uniprot id: D0LW50
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

502025:HOCH RS22985
gene id: 502025:HOCH_RS22985
uniprot id: D0LRB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

502025:HOCH RS13365
gene id: 502025:HOCH_RS13365
uniprot id: D0LN84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

502025:HOCH RS10025
gene id: 502025:HOCH_RS10025
uniprot id: D0LFZ9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS00135
gene id: 502025:HOCH_RS00135
uniprot id: D0LFN4
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

502025:HOCH RS13480
gene id: 502025:HOCH_RS13480
uniprot id: D0LNA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

502025:HOCH RS14615
gene id: 502025:HOCH_RS14615
uniprot id: D0LQZ1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS21275
gene id: 502025:HOCH_RS21275
uniprot id: D0LM96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

502025:HOCH RS00580
gene id: 502025:HOCH_RS00580
uniprot id: D0LGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS17260
gene id: 502025:HOCH_RS17260
uniprot id: D0LW88
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

502025:HOCH RS26230
gene id: 502025:HOCH_RS26230
uniprot id: D0LXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

502025:HOCH RS17610
gene id: 502025:HOCH_RS17610
uniprot id: D0LX49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

502025:HOCH RS08810
gene id: 502025:HOCH_RS08810
uniprot id: D0LY09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

502025:HOCH RS29465
gene id: 502025:HOCH_RS29465
uniprot id: D0LIP6
names: Similarity
messages: Belongs to the thioredoxin family.

502025:HOCH RS18850
gene id: 502025:HOCH_RS18850
uniprot id: D0LZ73
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferritin-like superfamily. EncFtn family.
messages: Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like ferroxidase that converts Fe(2+) to Fe(3+) iron inside the encapsulin nanocompartment (PubMed:30837306, PubMed:35080974). Mineralized Fe(3+) is released to the exterior of the decameric complex for deposition in the encapsulin nanocompartment. In solution the decamer binds 10-15 iron cations; in the encapsulin nanocompartment the decamer can bind up to 48 ions, perhaps via its internal channel, and on its exterior. The cargo-loaded nanocompartment maximally sequesters up to 4150 Fe ions (By similarity).
messages: Encapsulin nanocompartment
messages: Forms dimers at all pH tested; under acidic conditions formes decamers. The N-terminal domain (residues 1-97) crystallizes as a decameric ring (PubMed:30837306). Four decamers are loaded in the encapsulin nanocompartment in a tetrahedral arrangement. A 3 nm gap is consistently seen between the shell and the cargo. The target peptide extends away from the decameric ring, to allow binding to the interior of the encapsulin nanocompartment shell (PubMed:35080974).
messages: The decamer has negatively charged patches on its exterior, and a negatively charged tunnel at the center, the charges are probably metal-binding sites.
messages: The ferroxidase activity is inhibited by zinc.

502025:HOCH RS10855
gene id: 502025:HOCH_RS10855
uniprot id: D0LHT4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS10425
gene id: 502025:HOCH_RS10425
uniprot id: D0LGV6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

502025:HOCH RS19300
gene id: 502025:HOCH_RS19300
uniprot id: D0LZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS33600
gene id: 502025:HOCH_RS33600
uniprot id: D0LUA5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

502025:HOCH RS23935
gene id: 502025:HOCH_RS23935
uniprot id: D0LSV0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS07100
gene id: 502025:HOCH_RS07100
uniprot id: D0LUY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

502025:HOCH RS01985
gene id: 502025:HOCH_RS01985
uniprot id: D0LJ02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

502025:HOCH RS20195
gene id: 502025:HOCH_RS20195
uniprot id: D0LJL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

502025:HOCH RS29605
gene id: 502025:HOCH_RS29605
uniprot id: D0LJS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

502025:HOCH RS16715
gene id: 502025:HOCH_RS16715
uniprot id: D0LV72
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

502025:HOCH RS14605
gene id: 502025:HOCH_RS14605
uniprot id: D0LQY9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

502025:HOCH RS30015
gene id: 502025:HOCH_RS30015
uniprot id: D0LK07
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

502025:HOCH RS12460
gene id: 502025:HOCH_RS12460
uniprot id: D0LKN5
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

502025:HOCH RS30980
gene id: 502025:HOCH_RS30980
uniprot id: D0LMM1
names: Similarity
messages: Belongs to the Gfa family.

502025:HOCH RS08625
gene id: 502025:HOCH_RS08625
uniprot id: D0LXX2
names: Similarity
messages: Belongs to the asparaginase 1 family.

502025:HOCH RS22655
gene id: 502025:HOCH_RS22655
uniprot id: D0LQ36
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

502025:HOCH RS09290
gene id: 502025:HOCH_RS09290
uniprot id: D0LYY7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

502025:HOCH RS22595
gene id: 502025:HOCH_RS22595
uniprot id: D0LQ24
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09475
gene id: 502025:HOCH_RS09475
uniprot id: D0LZ22
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

502025:HOCH RS16185
gene id: 502025:HOCH_RS16185
uniprot id: D0LTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS21530
gene id: 502025:HOCH_RS21530
uniprot id: D0LME7
names: Subunit
messages: Homodimer.

502025:HOCH RS22755
gene id: 502025:HOCH_RS22755
uniprot id: D0LQ56
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS09515
gene id: 502025:HOCH_RS09515
uniprot id: D0LZ30
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS12715
gene id: 502025:HOCH_RS12715
uniprot id: D0LLV8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS20205
gene id: 502025:HOCH_RS20205
uniprot id: D0LJM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

502025:HOCH RS07545
gene id: 502025:HOCH_RS07545
uniprot id: D0LVX8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS17375
gene id: 502025:HOCH_RS17375
uniprot id: D0LWB0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

502025:HOCH RS08665
gene id: 502025:HOCH_RS08665
uniprot id: D0LXY0
names: Similarity
messages: Belongs to the aspartokinase family.

502025:HOCH RS19670
gene id: 502025:HOCH_RS19670
uniprot id: D0LIB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

502025:HOCH RS17950
gene id: 502025:HOCH_RS17950
uniprot id: D0LXB9
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

502025:HOCH RS15600
gene id: 502025:HOCH_RS15600
uniprot id: D0LSJ0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

502025:HOCH RS16840
gene id: 502025:HOCH_RS16840
uniprot id: D0LV96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

502025:HOCH RS06485
gene id: 502025:HOCH_RS06485
uniprot id: D0LTK5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS12505
gene id: 502025:HOCH_RS12505
uniprot id: D0LKP5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS16380
gene id: 502025:HOCH_RS16380
uniprot id: D0LV05
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS25150
gene id: 502025:HOCH_RS25150
uniprot id: D0LVJ8
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

502025:HOCH RS36805
gene id: 502025:HOCH_RS36805
uniprot id: D0LWF4
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS10750
gene id: 502025:HOCH_RS10750
uniprot id: D0LH20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

502025:HOCH RS11465
gene id: 502025:HOCH_RS11465
uniprot id: D0LJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

502025:HOCH RS26635
gene id: 502025:HOCH_RS26635
uniprot id: D0LYI2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS27645
gene id: 502025:HOCH_RS27645
uniprot id: D0LZR4
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

502025:HOCH RS11235
gene id: 502025:HOCH_RS11235
uniprot id: D0LI10
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09500
gene id: 502025:HOCH_RS09500
uniprot id: D0LZ27
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS25430
gene id: 502025:HOCH_RS25430
uniprot id: D0LWG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

502025:HOCH RS11695
gene id: 502025:HOCH_RS11695
uniprot id: D0LJ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

502025:HOCH RS19250
gene id: 502025:HOCH_RS19250
uniprot id: D0LZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

502025:HOCH RS11005
gene id: 502025:HOCH_RS11005
uniprot id: D0LHW3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

502025:HOCH RS18545
gene id: 502025:HOCH_RS18545
uniprot id: D0LYC5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS31500
gene id: 502025:HOCH_RS31500
uniprot id: D0LNY1
names: Similarity
messages: Belongs to the mycobacterial A85 antigen family.

502025:HOCH RS06790
gene id: 502025:HOCH_RS06790
uniprot id: D0LUS1
names: Similarity
messages: Belongs to the GST superfamily.

502025:HOCH RS13230
gene id: 502025:HOCH_RS13230
uniprot id: D0LN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

502025:HOCH RS13880
gene id: 502025:HOCH_RS13880
uniprot id: D0LPK0
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24825
gene id: 502025:HOCH_RS24825
uniprot id: D0LVD6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

502025:HOCH RS24225
gene id: 502025:HOCH_RS24225
uniprot id: D0LU14
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS36820
gene id: 502025:HOCH_RS36820
uniprot id: D0LWG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS19660
gene id: 502025:HOCH_RS19660
uniprot id: D0LIB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS23350
gene id: 502025:HOCH_RS23350
uniprot id: D0LRI1
names: Similarity
messages: Belongs to the UPF0235 family.

502025:HOCH RS34305
gene id: 502025:HOCH_RS34305
uniprot id: D0LVP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

502025:HOCH RS27395
gene id: 502025:HOCH_RS27395
uniprot id: D0LZL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

502025:HOCH RS19770
gene id: 502025:HOCH_RS19770
uniprot id: D0LJE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

502025:HOCH RS17835
gene id: 502025:HOCH_RS17835
uniprot id: D0LX95
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24805
gene id: 502025:HOCH_RS24805
uniprot id: D0LVD2
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS16110
gene id: 502025:HOCH_RS16110
uniprot id: D0LTU8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS14990
gene id: 502025:HOCH_RS14990
uniprot id: D0LR62
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

502025:HOCH RS08135
gene id: 502025:HOCH_RS08135
uniprot id: D0LWX9
names: Similarity
messages: Belongs to the Gfa family.

502025:HOCH RS27390
gene id: 502025:HOCH_RS27390
uniprot id: D0LZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

502025:HOCH RS34945
gene id: 502025:HOCH_RS34945
uniprot id: D0LS56
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

502025:HOCH RS26525
gene id: 502025:HOCH_RS26525
uniprot id: D0LYG0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS14630
gene id: 502025:HOCH_RS14630
uniprot id: D0LQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

502025:HOCH RS24040
gene id: 502025:HOCH_RS24040
uniprot id: D0LSX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

502025:HOCH RS18450
gene id: 502025:HOCH_RS18450
uniprot id: D0LYA5
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

502025:HOCH RS28880
gene id: 502025:HOCH_RS28880
uniprot id: D0LHE1
names: Similarity
messages: Belongs to the peptidase M24B family.

502025:HOCH RS27935
gene id: 502025:HOCH_RS27935
uniprot id: D0LG76
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

502025:HOCH RS21115
gene id: 502025:HOCH_RS21115
uniprot id: D0LM64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

502025:HOCH RS19605
gene id: 502025:HOCH_RS19605
uniprot id: D0LIA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

502025:HOCH RS04550
gene id: 502025:HOCH_RS04550
uniprot id: D0LQI9
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS15840
gene id: 502025:HOCH_RS15840
uniprot id: D0LTP3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

502025:HOCH RS19685
gene id: 502025:HOCH_RS19685
uniprot id: D0LIB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

502025:HOCH RS21280
gene id: 502025:HOCH_RS21280
uniprot id: D0LM97
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

502025:HOCH RS29105
gene id: 502025:HOCH_RS29105
uniprot id: D0LIH5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

502025:HOCH RS03590
gene id: 502025:HOCH_RS03590
uniprot id: D0LMY4
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

502025:HOCH RS34345
gene id: 502025:HOCH_RS34345
uniprot id: D0LGG5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS18190
gene id: 502025:HOCH_RS18190
uniprot id: D0LY57
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

502025:HOCH RS21990
gene id: 502025:HOCH_RS21990
uniprot id: D0LNP1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS12200
gene id: 502025:HOCH_RS12200
uniprot id: D0LKI3
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS30455
gene id: 502025:HOCH_RS30455
uniprot id: D0LLA6
names: Similarity
messages: Belongs to the SusD family.

502025:HOCH RS21620
gene id: 502025:HOCH_RS21620
uniprot id: D0LMG4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS08925
gene id: 502025:HOCH_RS08925
uniprot id: D0LY31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

502025:HOCH RS16160
gene id: 502025:HOCH_RS16160
uniprot id: D0LTV8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS18360
gene id: 502025:HOCH_RS18360
uniprot id: D0LY89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS24285
gene id: 502025:HOCH_RS24285
uniprot id: D0LU28
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

502025:HOCH RS13875
gene id: 502025:HOCH_RS13875
uniprot id: D0LPJ9
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS21420
gene id: 502025:HOCH_RS21420
uniprot id: D0LMC5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22505
gene id: 502025:HOCH_RS22505
uniprot id: D0LQ08
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS29865
gene id: 502025:HOCH_RS29865
uniprot id: D0LJX6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

502025:HOCH RS02485
gene id: 502025:HOCH_RS02485
uniprot id: D0LK98
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS26375
gene id: 502025:HOCH_RS26375
uniprot id: D0LXP2
names: Similarity
messages: Belongs to the peptidase S8 family.

502025:HOCH RS22915
gene id: 502025:HOCH_RS22915
uniprot id: D0LR97
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

502025:HOCH RS06055
gene id: 502025:HOCH_RS06055
uniprot id: D0LTC4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS08040
gene id: 502025:HOCH_RS08040
uniprot id: D0LWW0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS19705
gene id: 502025:HOCH_RS19705
uniprot id: D0LIC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

502025:HOCH RS22620
gene id: 502025:HOCH_RS22620
uniprot id: D0LQ29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

502025:HOCH RS19665
gene id: 502025:HOCH_RS19665
uniprot id: D0LIB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

502025:HOCH RS26885
gene id: 502025:HOCH_RS26885
uniprot id: D0LYN2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS20485
gene id: 502025:HOCH_RS20485
uniprot id: D0LKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS30640
gene id: 502025:HOCH_RS30640
uniprot id: D0LLE4
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

502025:HOCH RS02005
gene id: 502025:HOCH_RS02005
uniprot id: D0LJ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

502025:HOCH RS19935
gene id: 502025:HOCH_RS19935
uniprot id: D0LJG9
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

502025:HOCH RS30195
gene id: 502025:HOCH_RS30195
uniprot id: D0LL54
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

502025:HOCH RS21790
gene id: 502025:HOCH_RS21790
uniprot id: D0LNK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

502025:HOCH RS12425
gene id: 502025:HOCH_RS12425
uniprot id: D0LKM8
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

502025:HOCH RS34245
gene id: 502025:HOCH_RS34245
uniprot id: D0LVN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

502025:HOCH RS12475
gene id: 502025:HOCH_RS12475
uniprot id: D0LKN8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

502025:HOCH RS18875
gene id: 502025:HOCH_RS18875
uniprot id: D0LZ78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

502025:HOCH RS28200
gene id: 502025:HOCH_RS28200
uniprot id: D0LGC6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS29945
gene id: 502025:HOCH_RS29945
uniprot id: D0LJZ3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

502025:HOCH RS18295
gene id: 502025:HOCH_RS18295
uniprot id: D0LY77
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

502025:HOCH RS22795
gene id: 502025:HOCH_RS22795
uniprot id: D0LQ65
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

502025:HOCH RS24620
gene id: 502025:HOCH_RS24620
uniprot id: D0LU93
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS24210
gene id: 502025:HOCH_RS24210
uniprot id: D0LU11
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS08110
gene id: 502025:HOCH_RS08110
uniprot id: D0LWX4
names: Function
names: Induction
names: Similarity
messages: Belongs to the actin family.
messages: Constitutively expressed.
messages: May be a dominant-negative inhibitor of eukaryotic actin polymerization.

502025:HOCH RS12085
gene id: 502025:HOCH_RS12085
uniprot id: D0LKG0
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

502025:HOCH RS32300
gene id: 502025:HOCH_RS32300
uniprot id: D0LQG0
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS32730
gene id: 502025:HOCH_RS32730
uniprot id: D0LRR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

502025:HOCH RS22310
gene id: 502025:HOCH_RS22310
uniprot id: D0LPX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

502025:HOCH RS08775
gene id: 502025:HOCH_RS08775
uniprot id: D0LY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

502025:HOCH RS19240
gene id: 502025:HOCH_RS19240
uniprot id: D0LZE6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

502025:HOCH RS11640
gene id: 502025:HOCH_RS11640
uniprot id: D0LJ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

502025:HOCH RS18560
gene id: 502025:HOCH_RS18560
uniprot id: D0LYC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS00825
gene id: 502025:HOCH_RS00825
uniprot id: D0LGQ4
names: Similarity
messages: Belongs to the group II decarboxylase family.

502025:HOCH RS31450
gene id: 502025:HOCH_RS31450
uniprot id: D0LNX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

502025:HOCH RS11530
gene id: 502025:HOCH_RS11530
uniprot id: D0LJ48
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

502025:HOCH RS21940
gene id: 502025:HOCH_RS21940
uniprot id: D0LNN1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

502025:HOCH RS22230
gene id: 502025:HOCH_RS22230
uniprot id: D0LPV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

502025:HOCH RS16615
gene id: 502025:HOCH_RS16615
uniprot id: D0LV52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS16375
gene id: 502025:HOCH_RS16375
uniprot id: D0LV04
names: Similarity
messages: Belongs to the peptidase U62 family.

502025:HOCH RS06585
gene id: 502025:HOCH_RS06585
uniprot id: D0LUM8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31575
gene id: 502025:HOCH_RS31575
uniprot id: D0LNZ6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

502025:HOCH RS12065
gene id: 502025:HOCH_RS12065
uniprot id: D0LKF6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

502025:HOCH RS30285
gene id: 502025:HOCH_RS30285
uniprot id: D0LL72
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

502025:HOCH RS24020
gene id: 502025:HOCH_RS24020
uniprot id: D0LSW7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

502025:HOCH RS22780
gene id: 502025:HOCH_RS22780
uniprot id: D0LQ62
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

502025:HOCH RS15895
gene id: 502025:HOCH_RS15895
uniprot id: D0LTQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

502025:HOCH RS28565
gene id: 502025:HOCH_RS28565
uniprot id: D0LH79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS27670
gene id: 502025:HOCH_RS27670
uniprot id: D0LZR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

502025:HOCH RS21510
gene id: 502025:HOCH_RS21510
uniprot id: D0LME3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

502025:HOCH RS18100
gene id: 502025:HOCH_RS18100
uniprot id: D0LY40
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

502025:HOCH RS22930
gene id: 502025:HOCH_RS22930
uniprot id: D0LRA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

502025:HOCH RS16205
gene id: 502025:HOCH_RS16205
uniprot id: D0LTW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS10745
gene id: 502025:HOCH_RS10745
uniprot id: D0LH18
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

502025:HOCH RS30500
gene id: 502025:HOCH_RS30500
uniprot id: D0LLB5
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

502025:HOCH RS29220
gene id: 502025:HOCH_RS29220
uniprot id: D0LIJ8
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

502025:HOCH RS10740
gene id: 502025:HOCH_RS10740
uniprot id: D0LH17
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

502025:HOCH RS02540
gene id: 502025:HOCH_RS02540
uniprot id: D0LKA8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

502025:HOCH RS28110
gene id: 502025:HOCH_RS28110
uniprot id: D0LGA8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS07945
gene id: 502025:HOCH_RS07945
uniprot id: D0LWU2
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

502025:HOCH RS15435
gene id: 502025:HOCH_RS15435
uniprot id: D0LSF8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

502025:HOCH RS28260
gene id: 502025:HOCH_RS28260
uniprot id: D0LGD8
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

502025:HOCH RS22535
gene id: 502025:HOCH_RS22535
uniprot id: D0LQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

502025:HOCH RS33035
gene id: 502025:HOCH_RS33035
uniprot id: D0LSY0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

502025:HOCH RS31985
gene id: 502025:HOCH_RS31985
uniprot id: D0LQ98
names: Cofactor
messages: Can also use Mn(2+) ion.

502025:HOCH RS32095
gene id: 502025:HOCH_RS32095
uniprot id: D0LQB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS02390
gene id: 502025:HOCH_RS02390
uniprot id: D0LK79
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS15995
gene id: 502025:HOCH_RS15995
uniprot id: D0LTS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS12090
gene id: 502025:HOCH_RS12090
uniprot id: D0LKG1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

502025:HOCH RS30450
gene id: 502025:HOCH_RS30450
uniprot id: D0LLA5
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS08315
gene id: 502025:HOCH_RS08315
uniprot id: D0LX16
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS25230
gene id: 502025:HOCH_RS25230
uniprot id: D0LVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS23925
gene id: 502025:HOCH_RS23925
uniprot id: D0LSU9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS18400
gene id: 502025:HOCH_RS18400
uniprot id: D0LY96
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

502025:HOCH RS18580
gene id: 502025:HOCH_RS18580
uniprot id: D0LYD2
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS15145
gene id: 502025:HOCH_RS15145
uniprot id: D0LSA2
names: Similarity
messages: Belongs to the pirin family.

502025:HOCH RS33475
gene id: 502025:HOCH_RS33475
uniprot id: D0LT67
names: Similarity
messages: Belongs to the BMP lipoprotein family.

502025:HOCH RS13850
gene id: 502025:HOCH_RS13850
uniprot id: D0LPJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS11445
gene id: 502025:HOCH_RS11445
uniprot id: D0LJ32
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS01760
gene id: 502025:HOCH_RS01760
uniprot id: D0LIV7
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

502025:HOCH RS25645
gene id: 502025:HOCH_RS25645
uniprot id: D0LWK5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS19680
gene id: 502025:HOCH_RS19680
uniprot id: D0LIB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS06010
gene id: 502025:HOCH_RS06010
uniprot id: D0LTB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

502025:HOCH RS17265
gene id: 502025:HOCH_RS17265
uniprot id: D0LW89
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS30150
gene id: 502025:HOCH_RS30150
uniprot id: D0LL45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

502025:HOCH RS22525
gene id: 502025:HOCH_RS22525
uniprot id: D0LQ12
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

502025:HOCH RS28560
gene id: 502025:HOCH_RS28560
uniprot id: D0LH78
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

502025:HOCH RS33265
gene id: 502025:HOCH_RS33265
uniprot id: D0LT27
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS16525
gene id: 502025:HOCH_RS16525
uniprot id: D0LV34
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

502025:HOCH RS19925
gene id: 502025:HOCH_RS19925
uniprot id: D0LJG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

502025:HOCH RS30045
gene id: 502025:HOCH_RS30045
uniprot id: D0LK14
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

502025:HOCH RS01350
gene id: 502025:HOCH_RS01350
uniprot id: D0LHP3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS18890
gene id: 502025:HOCH_RS18890
uniprot id: D0LZ81
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

502025:HOCH RS05075
gene id: 502025:HOCH_RS05075
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS25425
gene id: 502025:HOCH_RS25425
uniprot id: D0LWG4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

502025:HOCH RS12265
gene id: 502025:HOCH_RS12265
uniprot id: D0LKJ7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS13920
gene id: 502025:HOCH_RS13920
uniprot id: D0LPK8
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

502025:HOCH RS08295
gene id: 502025:HOCH_RS08295
uniprot id: D0LX12
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS14830
gene id: 502025:HOCH_RS14830
uniprot id: D0LR31
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS19835
gene id: 502025:HOCH_RS19835
uniprot id: D0LJF0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS13525
gene id: 502025:HOCH_RS13525
uniprot id: D0LNB6
names: Subunit
messages: Homodimer.

502025:HOCH RS08565
gene id: 502025:HOCH_RS08565
uniprot id: D0LXW0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS25040
gene id: 502025:HOCH_RS25040
uniprot id: D0LVH6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

502025:HOCH RS33620
gene id: 502025:HOCH_RS33620
uniprot id: D0LUA9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

502025:HOCH RS21885
gene id: 502025:HOCH_RS21885
uniprot id: D0LNM0
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS23910
gene id: 502025:HOCH_RS23910
uniprot id: D0LSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

502025:HOCH RS22980
gene id: 502025:HOCH_RS22980
uniprot id: D0LRB0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

502025:HOCH RS25100
gene id: 502025:HOCH_RS25100
uniprot id: D0LVI8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

502025:HOCH RS21670
gene id: 502025:HOCH_RS21670
uniprot id: D0LNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

502025:HOCH RS21290
gene id: 502025:HOCH_RS21290
uniprot id: D0LM99
names: Similarity
names: Subunit
messages: Belongs to the sigma-70 factor family. ECF subfamily.
messages: Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.

502025:HOCH RS01930
gene id: 502025:HOCH_RS01930
uniprot id: D0LIZ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

502025:HOCH RS29020
gene id: 502025:HOCH_RS29020
uniprot id: D0LIF9
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS24465
gene id: 502025:HOCH_RS24465
uniprot id: D0LU62
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS04195
gene id: 502025:HOCH_RS04195
uniprot id: D0LPB4
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

502025:HOCH RS12805
gene id: 502025:HOCH_RS12805
uniprot id: D0LLX6
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

502025:HOCH RS18150
gene id: 502025:HOCH_RS18150
uniprot id: D0LY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

502025:HOCH RS10320
gene id: 502025:HOCH_RS10320
uniprot id: D0LGT4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS32125
gene id: 502025:HOCH_RS32125
uniprot id: D0LQC4
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS24215
gene id: 502025:HOCH_RS24215
uniprot id: D0LU12
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS31330
gene id: 502025:HOCH_RS31330
uniprot id: D0LNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS06895
gene id: 502025:HOCH_RS06895
uniprot id: D0LUU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS18025
gene id: 502025:HOCH_RS18025
uniprot id: D0LXD4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS24710
gene id: 502025:HOCH_RS24710
uniprot id: D0LVB5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

502025:HOCH RS01650
gene id: 502025:HOCH_RS01650
uniprot id: D0LIT5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS21090
gene id: 502025:HOCH_RS21090
uniprot id: D0LM59
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

502025:HOCH RS26460
gene id: 502025:HOCH_RS26460
uniprot id: D0LXQ9
names: Similarity
messages: Belongs to the histone deacetylase family.

502025:HOCH RS27315
gene id: 502025:HOCH_RS27315
uniprot id: D0LZK1
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

502025:HOCH RS10775
gene id: 502025:HOCH_RS10775
uniprot id: D0LH25
names: Similarity
messages: Belongs to the peptidase S13 family.

502025:HOCH RS21715
gene id: 502025:HOCH_RS21715
uniprot id: D0LNI5
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

502025:HOCH RS40470
gene id: 502025:HOCH_RS40470
uniprot id: D0LVM0
names: Similarity
messages: Belongs to the creatininase superfamily.

502025:HOCH RS19905
gene id: 502025:HOCH_RS19905
uniprot id: D0LJG3
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

502025:HOCH RS19245
gene id: 502025:HOCH_RS19245
uniprot id: D0LZE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

502025:HOCH RS01970
gene id: 502025:HOCH_RS01970
uniprot id: D0LIZ9
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

502025:HOCH RS19760
gene id: 502025:HOCH_RS19760
uniprot id: D0LJE0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

502025:HOCH RS16415
gene id: 502025:HOCH_RS16415
uniprot id: D0LV12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Possible subunit of a heme lyase.

502025:HOCH RS06145
gene id: 502025:HOCH_RS06145
uniprot id: D0LTE0
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS26875
gene id: 502025:HOCH_RS26875
uniprot id: D0LYN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS17340
gene id: 502025:HOCH_RS17340
uniprot id: D0LWA4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS19965
gene id: 502025:HOCH_RS19965
uniprot id: D0LJH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

502025:HOCH RS22330
gene id: 502025:HOCH_RS22330
uniprot id: D0LPX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS14415
gene id: 502025:HOCH_RS14415
uniprot id: D0LPU9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS20605
gene id: 502025:HOCH_RS20605
uniprot id: D0LKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

502025:HOCH RS26435
gene id: 502025:HOCH_RS26435
uniprot id: D0LXQ4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

502025:HOCH RS36575
gene id: 502025:HOCH_RS36575
uniprot id: D0LRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

502025:HOCH RS12150
gene id: 502025:HOCH_RS12150
uniprot id: D0LKH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

502025:HOCH RS27715
gene id: 502025:HOCH_RS27715
uniprot id: D0LG32
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS32840
gene id: 502025:HOCH_RS32840
uniprot id: D0LRT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

502025:HOCH RS20265
gene id: 502025:HOCH_RS20265
uniprot id: D0LJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS33460
gene id: 502025:HOCH_RS33460
uniprot id: D0LT64
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS05645
gene id: 502025:HOCH_RS05645
uniprot id: D0LS45
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS21805
gene id: 502025:HOCH_RS21805
uniprot id: D0LNK3
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS20535
gene id: 502025:HOCH_RS20535
uniprot id: D0LKT6
names: Function
names: Similarity
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

502025:HOCH RS06925
gene id: 502025:HOCH_RS06925
uniprot id: D0LUV0
names: Subcellular Location Annotation
messages: Periplasm

502025:HOCH RS35220
gene id: 502025:HOCH_RS35220
uniprot id: D0LWX0
names: Similarity
messages: Belongs to the peptidase M4 family.

502025:HOCH RS36045
gene id: 502025:HOCH_RS36045
uniprot id: D0LWC9
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

502025:HOCH RS10270
gene id: 502025:HOCH_RS10270
uniprot id: D0LGS4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS17590
gene id: 502025:HOCH_RS17590
uniprot id: D0LX45
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS29035
gene id: 502025:HOCH_RS29035
uniprot id: D0LIG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

502025:HOCH RS24270
gene id: 502025:HOCH_RS24270
uniprot id: D0LU25
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

502025:HOCH RS22945
gene id: 502025:HOCH_RS22945
uniprot id: D0LRA3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS34040
gene id: 502025:HOCH_RS34040
uniprot id: D0LUJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

502025:HOCH RS31845
gene id: 502025:HOCH_RS31845
uniprot id: D0LQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS36460
gene id: 502025:HOCH_RS36460
uniprot id: D0LNP4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

502025:HOCH RS12295
gene id: 502025:HOCH_RS12295
uniprot id: D0LKK3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

502025:HOCH RS33870
gene id: 502025:HOCH_RS33870
uniprot id: D0LUF8
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

502025:HOCH RS29040
gene id: 502025:HOCH_RS29040
uniprot id: D0LIG3
names: Similarity
messages: Belongs to the YicC/YloC family.

502025:HOCH RS13220
gene id: 502025:HOCH_RS13220
uniprot id: D0LN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS33135
gene id: 502025:HOCH_RS33135
uniprot id: D0LT00
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

502025:HOCH RS15380
gene id: 502025:HOCH_RS15380
uniprot id: D0LSE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS24060
gene id: 502025:HOCH_RS24060
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS27340
gene id: 502025:HOCH_RS27340
uniprot id: D0LZK6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS10205
gene id: 502025:HOCH_RS10205
uniprot id: D0LGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

502025:HOCH RS17880
gene id: 502025:HOCH_RS17880
uniprot id: D0LXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

502025:HOCH RS21545
gene id: 502025:HOCH_RS21545
uniprot id: D0LMF0
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

502025:HOCH RS36720
gene id: 502025:HOCH_RS36720
uniprot id: D0LU74
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

502025:HOCH RS26710
gene id: 502025:HOCH_RS26710
uniprot id: D0LYJ7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS11770
gene id: 502025:HOCH_RS11770
uniprot id: D0LJ97
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

502025:HOCH RS28070
gene id: 502025:HOCH_RS28070
uniprot id: D0LGA0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

502025:HOCH RS21385
gene id: 502025:HOCH_RS21385
uniprot id: D0LMB7
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

502025:HOCH RS28060
gene id: 502025:HOCH_RS28060
uniprot id: D0LG98
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09820
gene id: 502025:HOCH_RS09820
uniprot id: D0LFV8
names: Similarity
messages: Belongs to the peptidase S8 family.

502025:HOCH RS23280
gene id: 502025:HOCH_RS23280
uniprot id: D0LRG7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS34235
gene id: 502025:HOCH_RS34235
uniprot id: D0LVN0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

502025:HOCH RS26820
gene id: 502025:HOCH_RS26820
uniprot id: D0LYL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

502025:HOCH RS29370
gene id: 502025:HOCH_RS29370
uniprot id: D0LIM7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS33665
gene id: 502025:HOCH_RS33665
uniprot id: D0LUB8
names: Similarity
messages: Belongs to the TlyA family.

502025:HOCH RS11805
gene id: 502025:HOCH_RS11805
uniprot id: D0LJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

502025:HOCH RS33375
gene id: 502025:HOCH_RS33375
uniprot id: D0LT48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

502025:HOCH RS41785
gene id: 502025:HOCH_RS41785
uniprot id: D0LG91
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

502025:HOCH RS25750
gene id: 502025:HOCH_RS25750
uniprot id: D0LWM5
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

502025:HOCH RS24360
gene id: 502025:HOCH_RS24360
uniprot id: D0LU42
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

502025:HOCH RS17575
gene id: 502025:HOCH_RS17575
uniprot id: D0LX42
names: Similarity
messages: Belongs to the TrpC family.

502025:HOCH RS25840
gene id: 502025:HOCH_RS25840
uniprot id: D0LWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.

502025:HOCH RS32065
gene id: 502025:HOCH_RS32065
uniprot id: D0LQB4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

502025:HOCH RS31865
gene id: 502025:HOCH_RS31865
uniprot id: D0LQ74
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

502025:HOCH RS33780
gene id: 502025:HOCH_RS33780
uniprot id: D0LUE0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

502025:HOCH RS19720
gene id: 502025:HOCH_RS19720
uniprot id: D0LIC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

502025:HOCH RS24205
gene id: 502025:HOCH_RS24205
uniprot id: D0LU10
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS36475
gene id: 502025:HOCH_RS36475
uniprot id: D0LPW0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

502025:HOCH RS01670
gene id: 502025:HOCH_RS01670
uniprot id: D0LIT9
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS31810
gene id: 502025:HOCH_RS31810
uniprot id: D0LP45
names: Similarity
messages: Belongs to the peptidase S9A family.

502025:HOCH RS27265
gene id: 502025:HOCH_RS27265
uniprot id: D0LZJ1
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

502025:HOCH RS34260
gene id: 502025:HOCH_RS34260
uniprot id: D0LVN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

502025:HOCH RS35875
gene id: 502025:HOCH_RS35875
uniprot id: D0LTR2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

502025:HOCH RS01935
gene id: 502025:HOCH_RS01935
uniprot id: D0LIZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

502025:HOCH RS22110
gene id: 502025:HOCH_RS22110
uniprot id: D0LNR4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

502025:HOCH RS32585
gene id: 502025:HOCH_RS32585
uniprot id: D0LRN5
names: Similarity
messages: Belongs to the UPF0047 family.

502025:HOCH RS16495
gene id: 502025:HOCH_RS16495
uniprot id: D0LV28
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS31650
gene id: 502025:HOCH_RS31650
uniprot id: D0LP12
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS07115
gene id: 502025:HOCH_RS07115
uniprot id: D0LVP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

502025:HOCH RS08070
gene id: 502025:HOCH_RS08070
uniprot id: D0LWW6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS14370
gene id: 502025:HOCH_RS14370
uniprot id: D0LPU2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS08055
gene id: 502025:HOCH_RS08055
uniprot id: D0LWW3
names: Similarity
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS31930
gene id: 502025:HOCH_RS31930
uniprot id: D0LQ87
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS12655
gene id: 502025:HOCH_RS12655
uniprot id: D0LLU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

502025:HOCH RS27260
gene id: 502025:HOCH_RS27260
uniprot id: D0LZJ0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS02210
gene id: 502025:HOCH_RS02210
uniprot id: D0LK43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

502025:HOCH RS32390
gene id: 502025:HOCH_RS32390
uniprot id: D0LQI0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

502025:HOCH RS22760
gene id: 502025:HOCH_RS22760
uniprot id: D0LQ57
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS24850
gene id: 502025:HOCH_RS24850
uniprot id: D0LVE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS35010
gene id: 502025:HOCH_RS35010
uniprot id: D0LTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

502025:HOCH RS10810
gene id: 502025:HOCH_RS10810
uniprot id: D0LHS5
names: Similarity
messages: Belongs to the lycopene cyclase family.

502025:HOCH RS01240
gene id: 502025:HOCH_RS01240
uniprot id: D0LHM1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

502025:HOCH RS32195
gene id: 502025:HOCH_RS32195
uniprot id: D0LQD9
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS08265
gene id: 502025:HOCH_RS08265
uniprot id: D0LX06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

502025:HOCH RS26380
gene id: 502025:HOCH_RS26380
uniprot id: D0LXP3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

502025:HOCH RS21845
gene id: 502025:HOCH_RS21845
uniprot id: D0LNL2
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

502025:HOCH RS06590
gene id: 502025:HOCH_RS06590
uniprot id: D0LUN0
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

502025:HOCH RS21260
gene id: 502025:HOCH_RS21260
uniprot id: D0LM93
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS20725
gene id: 502025:HOCH_RS20725
uniprot id: D0LKX3
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

502025:HOCH RS25215
gene id: 502025:HOCH_RS25215
uniprot id: D0LVL1
names: Similarity
messages: Belongs to the PspA/IM30 family.

502025:HOCH RS14300
gene id: 502025:HOCH_RS14300
uniprot id: D0LPS9
names: Subcellular Location Annotation
messages: Secreted

502025:HOCH RS21835
gene id: 502025:HOCH_RS21835
uniprot id: D0LNK9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS05690
gene id: 502025:HOCH_RS05690
uniprot id: D0LS54
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS21315
gene id: 502025:HOCH_RS21315
uniprot id: D0LMA4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

502025:HOCH RS01710
gene id: 502025:HOCH_RS01710
uniprot id: D0LIU7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS12770
gene id: 502025:HOCH_RS12770
uniprot id: D0LLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS34285
gene id: 502025:HOCH_RS34285
uniprot id: D0LVN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

502025:HOCH RS15375
gene id: 502025:HOCH_RS15375
uniprot id: D0LSE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS01345
gene id: 502025:HOCH_RS01345
uniprot id: D0LHP2
names: Similarity
messages: Belongs to the BolA/IbaG family.

502025:HOCH RS11985
gene id: 502025:HOCH_RS11985
uniprot id: D0LKD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

502025:HOCH RS28910
gene id: 502025:HOCH_RS28910
uniprot id: D0LID6
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMCs with a molecular mass of 6.5 MDa. One of 2 stacked pseudohexamers in the BMC. There are 20 BMC-T pseudohexamers per BMC, composed of mixed BMC-T1, BMC-T2 and BMC-T3. The shell facets are 20-30 Angstroms thick, with 1 of the stacked BMC-T trimers protruding to the exterior (PubMed:28642439, PubMed:30833088). The stacked trimers may serve as conduits to allow chemical flux across the protein shell, gated by Arg-70 which contacts Glu-69 in an adjacent subunit; they are flexible enough to play a role in accommodating variations in shell assembly (Probable).
messages: Artificial BMCs can be made in E.coli by expressing (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) or (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)). Cargo proteins can be targeted to this BMC.
messages: Bacterial microcompartment
messages: Belongs to the EutL/PduB family.
messages: Homotrimerizes to form a pseudohexamer. These stack, with the concave faces together, in purified bacterial microcompartments (BMC).
messages: Not required for efficient BMC formation; when deleted from an artificial operon (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) being expressed in E.coli, normal BMC shells form.
messages: These proteins have 2 BMC domains which evolve independently of each other, giving the term pseudohexamer to the trimerized subunit. Although the homotrimer fills the approximate space of a BMC hexamer protein, the BMC-T trimers are more compact. Their universal presence in BMCs indicates their structural importance. The homohexamers form pores at least 5 Angstroms in diameter; in the stacked homohexamer 1 pore is open and the other is closed (PubMed:28642439). In the BMC the inner pore is fully or partially closed while the outer pore is closed (PubMed:30833088).

502025:HOCH RS30810
gene id: 502025:HOCH_RS30810
uniprot id: D0LMI7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS19675
gene id: 502025:HOCH_RS19675
uniprot id: D0LIB7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

502025:HOCH RS21085
gene id: 502025:HOCH_RS21085
uniprot id: D0LM58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

502025:HOCH RS34195
gene id: 502025:HOCH_RS34195
uniprot id: D0LVM3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS10800
gene id: 502025:HOCH_RS10800
uniprot id: D0LHS3
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22320
gene id: 502025:HOCH_RS22320
uniprot id: D0LPX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS10140
gene id: 502025:HOCH_RS10140
uniprot id: D0LG22
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS18910
gene id: 502025:HOCH_RS18910
uniprot id: D0LZ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

502025:HOCH RS24450
gene id: 502025:HOCH_RS24450
uniprot id: D0LU59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

502025:HOCH RS33145
gene id: 502025:HOCH_RS33145
uniprot id: D0LT02
names: Similarity
messages: Belongs to the lipase chaperone family.

502025:HOCH RS23170
gene id: 502025:HOCH_RS23170
uniprot id: D0LRE6
names: Similarity
messages: Belongs to the FPG family.

502025:HOCH RS17935
gene id: 502025:HOCH_RS17935
uniprot id: D0LXB6
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

502025:HOCH RS09370
gene id: 502025:HOCH_RS09370
uniprot id: D0LZ02
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

502025:HOCH RS00120
gene id: 502025:HOCH_RS00120
uniprot id: D0LFN2
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31995
gene id: 502025:HOCH_RS31995
uniprot id: D0LQA0
names: Similarity
messages: Belongs to the oxoprolinase family.

502025:HOCH RS18720
gene id: 502025:HOCH_RS18720
uniprot id: D0LZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS21890
gene id: 502025:HOCH_RS21890
uniprot id: D0LNM1
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

502025:HOCH RS10285
gene id: 502025:HOCH_RS10285
uniprot id: D0LGS7
names: Similarity
messages: Belongs to the TPP enzyme family.

502025:HOCH RS19845
gene id: 502025:HOCH_RS19845
uniprot id: D0LJF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

502025:HOCH RS14055
gene id: 502025:HOCH_RS14055
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS30365
gene id: 502025:HOCH_RS30365
uniprot id: D0LL88
names: Similarity
messages: Belongs to the type IA topoisomerase family.

502025:HOCH RS27530
gene id: 502025:HOCH_RS27530
uniprot id: D0LZP4
names: Similarity
messages: Belongs to the RutC family.

502025:HOCH RS30380
gene id: 502025:HOCH_RS30380
uniprot id: D0LL91
names: Similarity
messages: Belongs to the pirin family.

502025:HOCH RS32985
gene id: 502025:HOCH_RS32985
uniprot id: D0LRW5
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

502025:HOCH RS30220
gene id: 502025:HOCH_RS30220
uniprot id: D0LL59
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS20555
gene id: 502025:HOCH_RS20555
uniprot id: D0LKU0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

502025:HOCH RS19385
gene id: 502025:HOCH_RS19385
uniprot id: D0LI58
names: Function
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
messages: Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide. The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN. Requires the flavin reductase RutF to regenerate FMN in vivo.

502025:HOCH RS33465
gene id: 502025:HOCH_RS33465
uniprot id: D0LT65
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS29195
gene id: 502025:HOCH_RS29195
uniprot id: D0LIJ3
names: Similarity
messages: Belongs to the PspA/IM30 family.

502025:HOCH RS32700
gene id: 502025:HOCH_RS32700
uniprot id: D0LRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

502025:HOCH RS27155
gene id: 502025:HOCH_RS27155
uniprot id: D0LZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS34550
gene id: 502025:HOCH_RS34550
uniprot id: D0LLG4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

502025:HOCH RS32255
gene id: 502025:HOCH_RS32255
uniprot id: D0LQF1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS27735
gene id: 502025:HOCH_RS27735
uniprot id: D0LG36
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS10330
gene id: 502025:HOCH_RS10330
uniprot id: D0LGT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

502025:HOCH RS31955
gene id: 502025:HOCH_RS31955
uniprot id: D0LQ92
names: Similarity
messages: Belongs to the peptidase U62 family.

502025:HOCH RS36515
gene id: 502025:HOCH_RS36515
uniprot id: D0LQ10
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS25130
gene id: 502025:HOCH_RS25130
uniprot id: D0LVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

502025:HOCH RS02050
gene id: 502025:HOCH_RS02050
uniprot id: D0LJ16
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS02555
gene id: 502025:HOCH_RS02555
uniprot id: D0LKB1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

502025:HOCH RS10815
gene id: 502025:HOCH_RS10815
uniprot id: D0LHS6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

502025:HOCH RS17505
gene id: 502025:HOCH_RS17505
uniprot id: D0LX26
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

502025:HOCH RS32445
gene id: 502025:HOCH_RS32445
uniprot id: D0LRK8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31990
gene id: 502025:HOCH_RS31990
uniprot id: D0LQ99
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

502025:HOCH RS15610
gene id: 502025:HOCH_RS15610
uniprot id: D0LSJ2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

502025:HOCH RS25410
gene id: 502025:HOCH_RS25410
uniprot id: D0LWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

502025:HOCH RS11015
gene id: 502025:HOCH_RS11015
uniprot id: D0LHW5
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

502025:HOCH RS27585
gene id: 502025:HOCH_RS27585
uniprot id: D0LZQ4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

502025:HOCH RS18870
gene id: 502025:HOCH_RS18870
uniprot id: D0LZ77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

502025:HOCH RS21240
gene id: 502025:HOCH_RS21240
uniprot id: D0LM89
names: Similarity
messages: Belongs to the SCO1/2 family.

502025:HOCH RS01755
gene id: 502025:HOCH_RS01755
uniprot id: D0LIV6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS14505
gene id: 502025:HOCH_RS14505
uniprot id: D0LQX1
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS28385
gene id: 502025:HOCH_RS28385
uniprot id: D0LH43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

502025:HOCH RS14735
gene id: 502025:HOCH_RS14735
uniprot id: D0LR14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS05290
gene id: 502025:HOCH_RS05290
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS09375
gene id: 502025:HOCH_RS09375
uniprot id: D0LZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS26285
gene id: 502025:HOCH_RS26285
uniprot id: D0LXM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

502025:HOCH RS18885
gene id: 502025:HOCH_RS18885
uniprot id: D0LZ80
names: Similarity
messages: Belongs to the SAICAR synthetase family.

502025:HOCH RS30325
gene id: 502025:HOCH_RS30325
uniprot id: D0LL80
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS20290
gene id: 502025:HOCH_RS20290
uniprot id: D0LJN6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

502025:HOCH RS04775
gene id: 502025:HOCH_RS04775
uniprot id: D0LQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS31535
gene id: 502025:HOCH_RS31535
uniprot id: D0LNY8
names: Similarity
messages: Belongs to the GSP E family.

502025:HOCH RS26725
gene id: 502025:HOCH_RS26725
uniprot id: D0LYK0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

502025:HOCH RS15850
gene id: 502025:HOCH_RS15850
uniprot id: D0LTP5
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

502025:HOCH RS26385
gene id: 502025:HOCH_RS26385
uniprot id: D0LXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

502025:HOCH RS16090
gene id: 502025:HOCH_RS16090
uniprot id: D0LTU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

502025:HOCH RS23735
gene id: 502025:HOCH_RS23735
uniprot id: D0LSR1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

502025:HOCH RS32670
gene id: 502025:HOCH_RS32670
uniprot id: D0LRQ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

502025:HOCH RS29520
gene id: 502025:HOCH_RS29520
uniprot id: D0LJQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS01170
gene id: 502025:HOCH_RS01170
uniprot id: D0LHK7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

502025:HOCH RS16005
gene id: 502025:HOCH_RS16005
uniprot id: D0LTS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

502025:HOCH RS09845
gene id: 502025:HOCH_RS09845
uniprot id: D0LFW3
names: Cofactor
messages: Binds 1 phosphopantetheine covalently.

502025:HOCH RS18750
gene id: 502025:HOCH_RS18750
uniprot id: D0LZ55
names: Similarity
messages: Belongs to the Lgt family.

502025:HOCH RS14750
gene id: 502025:HOCH_RS14750
uniprot id: D0LR17
names: Cofactor
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS11200
gene id: 502025:HOCH_RS11200
uniprot id: D0LI03
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

502025:HOCH RS16520
gene id: 502025:HOCH_RS16520
uniprot id: D0LV33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

502025:HOCH RS28400
gene id: 502025:HOCH_RS28400
uniprot id: D0LH46
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

502025:HOCH RS02040
gene id: 502025:HOCH_RS02040
uniprot id: D0LJ14
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

502025:HOCH RS17095
gene id: 502025:HOCH_RS17095
uniprot id: D0LW55
names: Similarity
messages: Belongs to the Gfa family.

502025:HOCH RS02690
gene id: 502025:HOCH_RS02690
uniprot id: D0LKD8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS20855
gene id: 502025:HOCH_RS20855
uniprot id: D0LKZ8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

502025:HOCH RS25445
gene id: 502025:HOCH_RS25445
uniprot id: D0LWG8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS16710
gene id: 502025:HOCH_RS16710
uniprot id: D0LV71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS00250
gene id: 502025:HOCH_RS00250
uniprot id: D0LFQ7
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

502025:HOCH RS29215
gene id: 502025:HOCH_RS29215
uniprot id: D0LIJ7
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

502025:HOCH RS22210
gene id: 502025:HOCH_RS22210
uniprot id: D0LNT4
names: Similarity
messages: Belongs to the peptidase S9A family.

502025:HOCH RS33845
gene id: 502025:HOCH_RS33845
uniprot id: D0LUF3
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

502025:HOCH RS32100
gene id: 502025:HOCH_RS32100
uniprot id: D0LQB9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

502025:HOCH RS11485
gene id: 502025:HOCH_RS11485
uniprot id: D0LJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

502025:HOCH RS26535
gene id: 502025:HOCH_RS26535
uniprot id: D0LYG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

502025:HOCH RS34275
gene id: 502025:HOCH_RS34275
uniprot id: D0LVN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS17510
gene id: 502025:HOCH_RS17510
uniprot id: D0LX27
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

502025:HOCH RS26645
gene id: 502025:HOCH_RS26645
uniprot id: D0LYI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

502025:HOCH RS20050
gene id: 502025:HOCH_RS20050
uniprot id: D0LJJ2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS31050
gene id: 502025:HOCH_RS31050
uniprot id: D0LMN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS36345
gene id: 502025:HOCH_RS36345
uniprot id: D0LL15
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Belongs to the phosphohexose mutase family.

502025:HOCH RS37285
gene id: 502025:HOCH_RS37285
uniprot id: D0LIM3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

502025:HOCH RS25500
gene id: 502025:HOCH_RS25500
uniprot id: D0LWH9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS12395
gene id: 502025:HOCH_RS12395
uniprot id: D0LKM3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS22925
gene id: 502025:HOCH_RS22925
uniprot id: D0LR99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

502025:HOCH RS16150
gene id: 502025:HOCH_RS16150
uniprot id: D0LTV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

502025:HOCH RS07165
gene id: 502025:HOCH_RS07165
uniprot id: D0LVQ4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

502025:HOCH RS10630
gene id: 502025:HOCH_RS10630
uniprot id: D0LGZ4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

502025:HOCH RS08025
gene id: 502025:HOCH_RS08025
uniprot id: D0LWV7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS20245
gene id: 502025:HOCH_RS20245
uniprot id: D0LJM9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS03110
gene id: 502025:HOCH_RS03110
uniprot id: D0LLP1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS11700
gene id: 502025:HOCH_RS11700
uniprot id: D0LJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

502025:HOCH RS11140
gene id: 502025:HOCH_RS11140
uniprot id: D0LHZ0
names: Function
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.

502025:HOCH RS01305
gene id: 502025:HOCH_RS01305
uniprot id: D0LHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

502025:HOCH RS10110
gene id: 502025:HOCH_RS10110
uniprot id: D0LG16
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS19350
gene id: 502025:HOCH_RS19350
uniprot id: D0LI51
names: Similarity
messages: Belongs to the peptidase S9C family.

502025:HOCH RS06005
gene id: 502025:HOCH_RS06005
uniprot id: D0LTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

502025:HOCH RS18725
gene id: 502025:HOCH_RS18725
uniprot id: D0LZ50
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS21685
gene id: 502025:HOCH_RS21685
uniprot id: D0LNH9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS08840
gene id: 502025:HOCH_RS08840
uniprot id: D0LY15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

502025:HOCH RS16305
gene id: 502025:HOCH_RS16305
uniprot id: D0LUZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

502025:HOCH RS29985
gene id: 502025:HOCH_RS29985
uniprot id: D0LK01
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

502025:HOCH RS35000
gene id: 502025:HOCH_RS35000
uniprot id: D0LTE5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS12710
gene id: 502025:HOCH_RS12710
uniprot id: D0LLV7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS25855
gene id: 502025:HOCH_RS25855
uniprot id: D0LWP4
names: Similarity
messages: Belongs to the type IB topoisomerase family.

502025:HOCH RS09725
gene id: 502025:HOCH_RS09725
uniprot id: D0LFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

502025:HOCH RS22235
gene id: 502025:HOCH_RS22235
uniprot id: D0LPV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

502025:HOCH RS30750
gene id: 502025:HOCH_RS30750
uniprot id: D0LMH5
names: Similarity
messages: Belongs to the peptidase S9C family.

502025:HOCH RS16010
gene id: 502025:HOCH_RS16010
uniprot id: D0LTS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

502025:HOCH RS16465
gene id: 502025:HOCH_RS16465
uniprot id: D0LV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

502025:HOCH RS11920
gene id: 502025:HOCH_RS11920
uniprot id: D0LJC7
names: Similarity
messages: Belongs to the ribF family.

502025:HOCH RS23820
gene id: 502025:HOCH_RS23820
uniprot id: D0LSS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS01485
gene id: 502025:HOCH_RS01485
uniprot id: D0LHS0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS27900
gene id: 502025:HOCH_RS27900
uniprot id: D0LG69
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

502025:HOCH RS00050
gene id: 502025:HOCH_RS00050
uniprot id: D0LFL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

502025:HOCH RS42970
gene id: 502025:HOCH_RS42970
uniprot id: D0LUL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

502025:HOCH RS33225
gene id: 502025:HOCH_RS33225
uniprot id: D0LT19
names: Similarity
messages: Belongs to the peptidase S1C family.

502025:HOCH RS36485
gene id: 502025:HOCH_RS36485
uniprot id: D0LPW6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

502025:HOCH RS00550
gene id: 502025:HOCH_RS00550
uniprot id: D0LGK4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

502025:HOCH RS01115
gene id: 502025:HOCH_RS01115
uniprot id: D0LHJ6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

502025:HOCH RS29030
gene id: 502025:HOCH_RS29030
uniprot id: D0LIG1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

502025:HOCH RS08955
gene id: 502025:HOCH_RS08955
uniprot id: D0LY37
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

502025:HOCH RS20780
gene id: 502025:HOCH_RS20780
uniprot id: D0LKY4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS28135
gene id: 502025:HOCH_RS28135
uniprot id: D0LGB3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS16945
gene id: 502025:HOCH_RS16945
uniprot id: D0LW25
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS12635
gene id: 502025:HOCH_RS12635
uniprot id: D0LLU1
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

502025:HOCH RS24820
gene id: 502025:HOCH_RS24820
uniprot id: D0LVD5
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS20475
gene id: 502025:HOCH_RS20475
uniprot id: D0LKS5
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

502025:HOCH RS08280
gene id: 502025:HOCH_RS08280
uniprot id: D0LX09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

502025:HOCH RS29470
gene id: 502025:HOCH_RS29470
uniprot id: D0LIP7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS25975
gene id: 502025:HOCH_RS25975
uniprot id: D0LXG2
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

502025:HOCH RS20820
gene id: 502025:HOCH_RS20820
uniprot id: D0LKZ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

502025:HOCH RS22245
gene id: 502025:HOCH_RS22245
uniprot id: D0LPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

502025:HOCH RS17410
gene id: 502025:HOCH_RS17410
uniprot id: D0LWB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

502025:HOCH RS33195
gene id: 502025:HOCH_RS33195
uniprot id: D0LT13
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

502025:HOCH RS24440
gene id: 502025:HOCH_RS24440
uniprot id: D0LU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

502025:HOCH RS19615
gene id: 502025:HOCH_RS19615
uniprot id: D0LIA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

502025:HOCH RS10250
gene id: 502025:HOCH_RS10250
uniprot id: D0LGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS19610
gene id: 502025:HOCH_RS19610
uniprot id: D0LIA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

502025:HOCH RS18165
gene id: 502025:HOCH_RS18165
uniprot id: D0LY52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

502025:HOCH RS34240
gene id: 502025:HOCH_RS34240
uniprot id: D0LVN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

502025:HOCH RS29600
gene id: 502025:HOCH_RS29600
uniprot id: D0LJS2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

502025:HOCH RS02445
gene id: 502025:HOCH_RS02445
uniprot id: D0LK91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

502025:HOCH RS25535
gene id: 502025:HOCH_RS25535
uniprot id: D0LWI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

502025:HOCH RS26175
gene id: 502025:HOCH_RS26175
uniprot id: D0LXK2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

502025:HOCH RS19700
gene id: 502025:HOCH_RS19700
uniprot id: D0LIC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

502025:HOCH RS26615
gene id: 502025:HOCH_RS26615
uniprot id: D0LYH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

502025:HOCH RS00490
gene id: 502025:HOCH_RS00490
uniprot id: D0LGJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

502025:HOCH RS34085
gene id: 502025:HOCH_RS34085
uniprot id: D0LUK1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

502025:HOCH RS08730
gene id: 502025:HOCH_RS08730
uniprot id: D0LXZ3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

502025:HOCH RS09495
gene id: 502025:HOCH_RS09495
uniprot id: D0LZ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

502025:HOCH RS36245
gene id: 502025:HOCH_RS36245
uniprot id: D0LI94
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS29460
gene id: 502025:HOCH_RS29460
uniprot id: D0LIP5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

502025:HOCH RS29615
gene id: 502025:HOCH_RS29615
uniprot id: D0LJS5
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

502025:HOCH RS23575
gene id: 502025:HOCH_RS23575
uniprot id: D0LSN1
names: Similarity
messages: Belongs to the YciI family.

502025:HOCH RS27490
gene id: 502025:HOCH_RS27490
uniprot id: D0LZN6
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS28545
gene id: 502025:HOCH_RS28545
uniprot id: D0LH75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

502025:HOCH RS06935
gene id: 502025:HOCH_RS06935
uniprot id: D0LUV2
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS12130
gene id: 502025:HOCH_RS12130
uniprot id: D0LKG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

502025:HOCH RS29270
gene id: 502025:HOCH_RS29270
uniprot id: D0LIK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

502025:HOCH RS06045
gene id: 502025:HOCH_RS06045
uniprot id: D0LTC2
names: Similarity
messages: Belongs to the terpene synthase family.

502025:HOCH RS11845
gene id: 502025:HOCH_RS11845
uniprot id: D0LJB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS24515
gene id: 502025:HOCH_RS24515
uniprot id: D0LU72
names: Similarity
messages: Belongs to the aspartokinase family.

502025:HOCH RS28420
gene id: 502025:HOCH_RS28420
uniprot id: D0LH50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

502025:HOCH RS29790
gene id: 502025:HOCH_RS29790
uniprot id: D0LJW1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS30775
gene id: 502025:HOCH_RS30775
uniprot id: D0LMI0
names: Similarity
messages: Belongs to the group II decarboxylase family.

502025:HOCH RS21550
gene id: 502025:HOCH_RS21550
uniprot id: D0LMF1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS01690
gene id: 502025:HOCH_RS01690
uniprot id: D0LIU3
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

502025:HOCH RS22305
gene id: 502025:HOCH_RS22305
uniprot id: D0LPX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS18530
gene id: 502025:HOCH_RS18530
uniprot id: D0LYC2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

502025:HOCH RS33310
gene id: 502025:HOCH_RS33310
uniprot id: D0LT35
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

502025:HOCH RS15500
gene id: 502025:HOCH_RS15500
uniprot id: D0LSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

502025:HOCH RS17270
gene id: 502025:HOCH_RS17270
uniprot id: D0LW90
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31280
gene id: 502025:HOCH_RS31280
uniprot id: D0LNT7
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS24765
gene id: 502025:HOCH_RS24765
uniprot id: D0LVC4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

502025:HOCH RS32890
gene id: 502025:HOCH_RS32890
uniprot id: D0LRU6
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS19780
gene id: 502025:HOCH_RS19780
uniprot id: D0LJE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

502025:HOCH RS19580
gene id: 502025:HOCH_RS19580
uniprot id: D0LI97
names: Similarity
messages: Belongs to the creatininase superfamily.

502025:HOCH RS10920
gene id: 502025:HOCH_RS10920
uniprot id: D0LHU5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS17630
gene id: 502025:HOCH_RS17630
uniprot id: D0LX53
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS14745
gene id: 502025:HOCH_RS14745
uniprot id: D0LR16
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

502025:HOCH RS21870
gene id: 502025:HOCH_RS21870
uniprot id: D0LNL7
names: Similarity
messages: Belongs to the pyruvate kinase family.

502025:HOCH RS19550
gene id: 502025:HOCH_RS19550
uniprot id: D0LI91
names: Similarity
messages: Belongs to the Skp family.

502025:HOCH RS30130
gene id: 502025:HOCH_RS30130
uniprot id: D0LL41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

502025:HOCH RS33355
gene id: 502025:HOCH_RS33355
uniprot id: D0LT44
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

502025:HOCH RS16050
gene id: 502025:HOCH_RS16050
uniprot id: D0LTT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS36100
gene id: 502025:HOCH_RS36100
uniprot id: D0LXB1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS29775
gene id: 502025:HOCH_RS29775
uniprot id: D0LJV8
names: Similarity
messages: Belongs to the SCO1/2 family.

502025:HOCH RS30315
gene id: 502025:HOCH_RS30315
uniprot id: D0LL78
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

502025:HOCH RS19730
gene id: 502025:HOCH_RS19730
uniprot id: D0LIC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

502025:HOCH RS19375
gene id: 502025:HOCH_RS19375
uniprot id: D0LI56
names: Function
names: Similarity
messages: Belongs to the isochorismatase family. RutB subfamily.
messages: Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate. The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.

502025:HOCH RS10665
gene id: 502025:HOCH_RS10665
uniprot id: D0LH01
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS01635
gene id: 502025:HOCH_RS01635
uniprot id: D0LIT2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

502025:HOCH RS02010
gene id: 502025:HOCH_RS02010
uniprot id: D0LJ07
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

502025:HOCH RS25565
gene id: 502025:HOCH_RS25565
uniprot id: D0LWJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS32825
gene id: 502025:HOCH_RS32825
uniprot id: D0LRT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

502025:HOCH RS24665
gene id: 502025:HOCH_RS24665
uniprot id: D0LUA2
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

502025:HOCH RS18105
gene id: 502025:HOCH_RS18105
uniprot id: D0LY41
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS17185
gene id: 502025:HOCH_RS17185
uniprot id: D0LW73
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

502025:HOCH RS25890
gene id: 502025:HOCH_RS25890
uniprot id: D0LWQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

502025:HOCH RS01865
gene id: 502025:HOCH_RS01865
uniprot id: D0LIX7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

502025:HOCH RS12140
gene id: 502025:HOCH_RS12140
uniprot id: D0LKH1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

502025:HOCH RS15225
gene id: 502025:HOCH_RS15225
uniprot id: D0LSB7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS31550
gene id: 502025:HOCH_RS31550
uniprot id: D0LNZ1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

502025:HOCH RS21300
gene id: 502025:HOCH_RS21300
uniprot id: D0LMA1
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

502025:HOCH RS12640
gene id: 502025:HOCH_RS12640
uniprot id: D0LLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS16925
gene id: 502025:HOCH_RS16925
uniprot id: D0LW21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

502025:HOCH RS20020
gene id: 502025:HOCH_RS20020
uniprot id: D0LJI6
names: Subcellular Location Annotation
messages: Cytoplasm

502025:HOCH RS26470
gene id: 502025:HOCH_RS26470
uniprot id: D0LXR1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

502025:HOCH RS17585
gene id: 502025:HOCH_RS17585
uniprot id: D0LX44
names: Similarity
messages: Belongs to the citrate synthase family.

502025:HOCH RS22905
gene id: 502025:HOCH_RS22905
uniprot id: D0LR95
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS06255
gene id: 502025:HOCH_RS06255
uniprot id: D0LTG2
names: Similarity
messages: Belongs to the GST superfamily.

502025:HOCH RS31380
gene id: 502025:HOCH_RS31380
uniprot id: D0LNV8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS00915
gene id: 502025:HOCH_RS00915
uniprot id: D0LHF6
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

502025:HOCH RS07235
gene id: 502025:HOCH_RS07235
uniprot id: D0LVR7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS13665
gene id: 502025:HOCH_RS13665
uniprot id: D0LNE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

502025:HOCH RS34280
gene id: 502025:HOCH_RS34280
uniprot id: D0LVN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS33970
gene id: 502025:HOCH_RS33970
uniprot id: D0LUH8
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

502025:HOCH RS30400
gene id: 502025:HOCH_RS30400
uniprot id: D0LL95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PduL family.
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

502025:HOCH RS19695
gene id: 502025:HOCH_RS19695
uniprot id: D0LIC1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

502025:HOCH RS32555
gene id: 502025:HOCH_RS32555
uniprot id: D0LRM9
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

502025:HOCH RS22325
gene id: 502025:HOCH_RS22325
uniprot id: D0LPX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS29540
gene id: 502025:HOCH_RS29540
uniprot id: D0LJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

502025:HOCH RS22990
gene id: 502025:HOCH_RS22990
uniprot id: D0LRB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS05430
gene id: 502025:HOCH_RS05430
uniprot id: D0LS08
names: Similarity
messages: Belongs to the hcp beta-lactamase family.

502025:HOCH RS26015
gene id: 502025:HOCH_RS26015
uniprot id: D0LXH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

502025:HOCH RS13180
gene id: 502025:HOCH_RS13180
uniprot id: D0LN49
names: Similarity
messages: Belongs to the peptidase S9C family.

502025:HOCH RS03200
gene id: 502025:HOCH_RS03200
uniprot id: D0LLR0
names: Similarity
messages: Belongs to the phage portal family. PBSX subfamily.

502025:HOCH RS02415
gene id: 502025:HOCH_RS02415
uniprot id: D0LK84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

502025:HOCH RS00790
gene id: 502025:HOCH_RS00790
uniprot id: D0LGP7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

502025:HOCH RS26515
gene id: 502025:HOCH_RS26515
uniprot id: D0LYF8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS26095
gene id: 502025:HOCH_RS26095
uniprot id: D0LXI6
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

502025:HOCH RS00710
gene id: 502025:HOCH_RS00710
uniprot id: D0LGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

502025:HOCH RS29575
gene id: 502025:HOCH_RS29575
uniprot id: D0LJR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

502025:HOCH RS32845
gene id: 502025:HOCH_RS32845
uniprot id: D0LRT7
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

502025:HOCH RS26195
gene id: 502025:HOCH_RS26195
uniprot id: D0LXK6
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

502025:HOCH RS12080
gene id: 502025:HOCH_RS12080
uniprot id: D0LKF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS33935
gene id: 502025:HOCH_RS33935
uniprot id: D0LUH1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

502025:HOCH RS22265
gene id: 502025:HOCH_RS22265
uniprot id: D0LPW3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

502025:HOCH RS02860
gene id: 502025:HOCH_RS02860
uniprot id: D0LLI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

502025:HOCH RS26760
gene id: 502025:HOCH_RS26760
uniprot id: D0LYK7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS27365
gene id: 502025:HOCH_RS27365
uniprot id: D0LZL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS32230
gene id: 502025:HOCH_RS32230
uniprot id: D0LQE6
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS42905
gene id: 502025:HOCH_RS42905
uniprot id: D0LKZ4
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

502025:HOCH RS20995
gene id: 502025:HOCH_RS20995
uniprot id: D0LL25
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

502025:HOCH RS19145
gene id: 502025:HOCH_RS19145
uniprot id: D0LZC7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

502025:HOCH RS12145
gene id: 502025:HOCH_RS12145
uniprot id: D0LKH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

502025:HOCH RS17570
gene id: 502025:HOCH_RS17570
uniprot id: D0LX41
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS02855
gene id: 502025:HOCH_RS02855
uniprot id: D0LLI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

502025:HOCH RS16700
gene id: 502025:HOCH_RS16700
uniprot id: D0LV69
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

502025:HOCH RS41400
gene id: 502025:HOCH_RS41400
uniprot id: D0LTS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

502025:HOCH RS01960
gene id: 502025:HOCH_RS01960
uniprot id: D0LIZ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

502025:HOCH RS28265
gene id: 502025:HOCH_RS28265
uniprot id: D0LGD9
names: Similarity
messages: Belongs to the asparagine synthetase family.

502025:HOCH RS29235
gene id: 502025:HOCH_RS29235
uniprot id: D0LIK1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS27000
gene id: 502025:HOCH_RS27000
uniprot id: D0LYQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

502025:HOCH RS19635
gene id: 502025:HOCH_RS19635
uniprot id: D0LIA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

502025:HOCH RS35560
gene id: 502025:HOCH_RS35560
uniprot id: D0LJ87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

502025:HOCH RS25160
gene id: 502025:HOCH_RS25160
uniprot id: D0LVK0
names: Similarity
messages: Belongs to the NodU/CmcH family.

502025:HOCH RS28515
gene id: 502025:HOCH_RS28515
uniprot id: D0LH69
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

502025:HOCH RS08075
gene id: 502025:HOCH_RS08075
uniprot id: D0LWW7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

502025:HOCH RS10420
gene id: 502025:HOCH_RS10420
uniprot id: D0LGV5
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS27195
gene id: 502025:HOCH_RS27195
uniprot id: D0LZH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS33335
gene id: 502025:HOCH_RS33335
uniprot id: D0LT40
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS15690
gene id: 502025:HOCH_RS15690
uniprot id: D0LTL3
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

502025:HOCH RS07620
gene id: 502025:HOCH_RS07620
uniprot id: D0LVZ3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS29645
gene id: 502025:HOCH_RS29645
uniprot id: D0LJT2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

502025:HOCH RS24795
gene id: 502025:HOCH_RS24795
uniprot id: D0LVD0
names: Similarity
messages: Belongs to the ClpA/ClpB family.

502025:HOCH RS01330
gene id: 502025:HOCH_RS01330
uniprot id: D0LHN9
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

502025:HOCH RS32550
gene id: 502025:HOCH_RS32550
uniprot id: D0LRM8
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

502025:HOCH RS01070
gene id: 502025:HOCH_RS01070
uniprot id: D0LHI7
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

502025:HOCH RS17350
gene id: 502025:HOCH_RS17350
uniprot id: D0LWA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS31800
gene id: 502025:HOCH_RS31800
uniprot id: D0LP43
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS18180
gene id: 502025:HOCH_RS18180
uniprot id: D0LY55
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

502025:HOCH RS23875
gene id: 502025:HOCH_RS23875
uniprot id: D0LST9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

502025:HOCH RS34055
gene id: 502025:HOCH_RS34055
uniprot id: D0LUJ5
names: Similarity
messages: Belongs to the LOG family.

502025:HOCH RS26795
gene id: 502025:HOCH_RS26795
uniprot id: D0LYL4
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS12210
gene id: 502025:HOCH_RS12210
uniprot id: D0LKI5
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

502025:HOCH RS16805
gene id: 502025:HOCH_RS16805
uniprot id: D0LV90
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

502025:HOCH RS24775
gene id: 502025:HOCH_RS24775
uniprot id: D0LVC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

502025:HOCH RS30370
gene id: 502025:HOCH_RS30370
uniprot id: D0LL89
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

502025:HOCH RS23070
gene id: 502025:HOCH_RS23070
uniprot id: D0LRC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

502025:HOCH RS09395
gene id: 502025:HOCH_RS09395
uniprot id: D0LZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

502025:HOCH RS34360
gene id: 502025:HOCH_RS34360
uniprot id: D0LGH5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS28845
gene id: 502025:HOCH_RS28845
uniprot id: D0LHD4
names: Similarity
messages: Belongs to the GST superfamily.

502025:HOCH RS28405
gene id: 502025:HOCH_RS28405
uniprot id: D0LH47
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

502025:HOCH RS18185
gene id: 502025:HOCH_RS18185
uniprot id: D0LY56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

502025:HOCH RS00040
gene id: 502025:HOCH_RS00040
uniprot id: D0LFL6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

502025:HOCH RS29310
gene id: 502025:HOCH_RS29310
uniprot id: D0LIL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS33615
gene id: 502025:HOCH_RS33615
uniprot id: D0LUA8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

502025:HOCH RS32980
gene id: 502025:HOCH_RS32980
uniprot id: D0LRW4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

502025:HOCH RS01210
gene id: 502025:HOCH_RS01210
uniprot id: D0LHL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

502025:HOCH RS11495
gene id: 502025:HOCH_RS11495
uniprot id: D0LJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS36470
gene id: 502025:HOCH_RS36470
uniprot id: D0LNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

502025:HOCH RS37570
gene id: 502025:HOCH_RS37570
uniprot id: D0LRV1
names: Similarity
messages: Belongs to the peptidase C40 family.

502025:HOCH RS25540
gene id: 502025:HOCH_RS25540
uniprot id: D0LWI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

502025:HOCH RS11380
gene id: 502025:HOCH_RS11380
uniprot id: D0LI38
names: Similarity
messages: Belongs to the peptidase M17 family.

502025:HOCH RS01000
gene id: 502025:HOCH_RS01000
uniprot id: D0LHH3
names: Similarity
messages: Belongs to the AAA ATPase family.

502025:HOCH RS11890
gene id: 502025:HOCH_RS11890
uniprot id: D0LJC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

502025:HOCH RS33425
gene id: 502025:HOCH_RS33425
uniprot id: D0LT57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

502025:HOCH RS22260
gene id: 502025:HOCH_RS22260
uniprot id: D0LPW2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

502025:HOCH RS12510
gene id: 502025:HOCH_RS12510
uniprot id: D0LKP6
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS18855
gene id: 502025:HOCH_RS18855
uniprot id: D0LZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment
messages: Shell component of a type 1 encapsulin nanocompartment. Assembles into proteinaceous shells about 21 nm in diameter. Small pores form at, or close to, the 2-, 3-, and 5-fold symmetry axes. Data analysis suggests the 5-fold pores open and close with maximal and minimal aperatures of 15 and 5 Angstroms. Cargo protein Fer (ferritin-like protein, probably stores iron) is targeted to the interior via its C-terminal extension; empty intact shells can be isolated in the absence of cargo protein.
messages: This encapsulin nanocompartment is formed by 60 subunits; monomers form 12 pentamers which assemble to form shells. Shells are loaded with 4 encapsulated ferritin-like protein decamers (EncFtn) in a tetrahedral arrangement. A 3 nm gap is consistently seen between the shell and the cargo.

502025:HOCH RS01660
gene id: 502025:HOCH_RS01660
uniprot id: D0LIT7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS31980
gene id: 502025:HOCH_RS31980
uniprot id: D0LQ97
names: Similarity
messages: Belongs to the malate synthase family.

502025:HOCH RS01190
gene id: 502025:HOCH_RS01190
uniprot id: D0LHL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

502025:HOCH RS36190
gene id: 502025:HOCH_RS36190
uniprot id: D0LZ52
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS19960
gene id: 502025:HOCH_RS19960
uniprot id: D0LJH4
names: Similarity
messages: Belongs to the histone deacetylase family.

502025:HOCH RS16485
gene id: 502025:HOCH_RS16485
uniprot id: D0LV26
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS16115
gene id: 502025:HOCH_RS16115
uniprot id: D0LTU9
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

502025:HOCH RS17415
gene id: 502025:HOCH_RS17415
uniprot id: D0LWB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

502025:HOCH RS09520
gene id: 502025:HOCH_RS09520
uniprot id: D0LZ31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

502025:HOCH RS34095
gene id: 502025:HOCH_RS34095
uniprot id: D0LUK3
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

502025:HOCH RS12520
gene id: 502025:HOCH_RS12520
uniprot id: D0LKP8
names: Similarity
messages: Belongs to the LarC family.

502025:HOCH RS01925
gene id: 502025:HOCH_RS01925
uniprot id: D0LIY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

502025:HOCH RS41455
gene id: 502025:HOCH_RS41455
uniprot id: D0LWC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

502025:HOCH RS29345
gene id: 502025:HOCH_RS29345
uniprot id: D0LIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

502025:HOCH RS15215
gene id: 502025:HOCH_RS15215
uniprot id: D0LSB5
names: Similarity
messages: Belongs to the histone deacetylase family.

502025:HOCH RS19710
gene id: 502025:HOCH_RS19710
uniprot id: D0LIC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

502025:HOCH RS26650
gene id: 502025:HOCH_RS26650
uniprot id: D0LYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

502025:HOCH RS19630
gene id: 502025:HOCH_RS19630
uniprot id: D0LIA8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

502025:HOCH RS12955
gene id: 502025:HOCH_RS12955
uniprot id: D0LM05
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

502025:HOCH RS07145
gene id: 502025:HOCH_RS07145
uniprot id: D0LVQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

502025:HOCH RS00150
gene id: 502025:HOCH_RS00150
uniprot id: D0LFN7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

502025:HOCH RS09340
gene id: 502025:HOCH_RS09340
uniprot id: D0LYZ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

502025:HOCH RS25250
gene id: 502025:HOCH_RS25250
uniprot id: D0LVL8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

502025:HOCH RS22075
gene id: 502025:HOCH_RS22075
uniprot id: D0LNQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

502025:HOCH RS30570
gene id: 502025:HOCH_RS30570
uniprot id: D0LLD0
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS01220
gene id: 502025:HOCH_RS01220
uniprot id: D0LHL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

502025:HOCH RS08475
gene id: 502025:HOCH_RS08475
uniprot id: D0LXU1
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS11960
gene id: 502025:HOCH_RS11960
uniprot id: D0LJD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

502025:HOCH RS24700
gene id: 502025:HOCH_RS24700
uniprot id: D0LVB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

502025:HOCH RS32535
gene id: 502025:HOCH_RS32535
uniprot id: D0LRM5
names: Cofactor
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

502025:HOCH RS00025
gene id: 502025:HOCH_RS00025
uniprot id: D0LFL3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

502025:HOCH RS12115
gene id: 502025:HOCH_RS12115
uniprot id: D0LKG6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

502025:HOCH RS00055
gene id: 502025:HOCH_RS00055
uniprot id: D0LFL9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

502025:HOCH RS20275
gene id: 502025:HOCH_RS20275
uniprot id: D0LJN4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

502025:HOCH RS27525
gene id: 502025:HOCH_RS27525
uniprot id: D0LZP3
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS16120
gene id: 502025:HOCH_RS16120
uniprot id: D0LTV0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

502025:HOCH RS03750
gene id: 502025:HOCH_RS03750
uniprot id: D0LLP1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS16895
gene id: 502025:HOCH_RS16895
uniprot id: D0LW16
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS17335
gene id: 502025:HOCH_RS17335
uniprot id: D0LWA3
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22800
gene id: 502025:HOCH_RS22800
uniprot id: D0LQ66
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

502025:HOCH RS10015
gene id: 502025:HOCH_RS10015
uniprot id: D0LFZ7
names: Similarity
messages: Belongs to the peptidase S8 family.

502025:HOCH RS07580
gene id: 502025:HOCH_RS07580
uniprot id: D0LVY5
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

502025:HOCH RS24935
gene id: 502025:HOCH_RS24935
uniprot id: D0LVF6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS19600
gene id: 502025:HOCH_RS19600
uniprot id: D0LIA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

502025:HOCH RS10720
gene id: 502025:HOCH_RS10720
uniprot id: D0LH13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

502025:HOCH RS28900
gene id: 502025:HOCH_RS28900
uniprot id: D0LHE5
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Artificial BMCs can be made in E.coli by expressing (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) or (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)). Cargo proteins can be targeted to this BMC (PubMed:24631000, PubMed:28642439). BMC-H can be modified to place its N- and C-terminii in the interior of the shell (called CPH). Fusing proteins to the C-terminus of CPH allows targeting of cargo proteins to the lumen of the organelle composed of CPH, BMC-P and BMC-T1 (PubMed:31075444).
messages: Bacterial microcompartment
messages: Belongs to the CcmL/EutN family.
messages: Forms vertices in bacterial microcompartment (BMC) shells. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMC with a molecular mass of 6.5 MDa. There are 12 BMC-P pentamers per BMC. The shell facets are 20-30 Angstroms thick, with 1 of BMC-T trimers protruding to the exterior.
messages: Homopentamer. The base of the pyramid faces outward.
messages: Not essential for BMC formation; when an artificial operon without BMC-P proteins (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816) is expressed in E.coli BMC shells are made.
messages: One of 3 BMC-P proteins in this bacteria, the others are Hoch_4425 and Hoch_4426.

502025:HOCH RS16610
gene id: 502025:HOCH_RS16610
uniprot id: D0LV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS22495
gene id: 502025:HOCH_RS22495
uniprot id: D0LQ06
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

502025:HOCH RS24435
gene id: 502025:HOCH_RS24435
uniprot id: D0LU56
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS17580
gene id: 502025:HOCH_RS17580
uniprot id: D0LX43
names: Similarity
messages: Belongs to the TrpF family.

502025:HOCH RS27125
gene id: 502025:HOCH_RS27125
uniprot id: D0LZG3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

502025:HOCH RS24035
gene id: 502025:HOCH_RS24035
uniprot id: D0LSW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

502025:HOCH RS19800
gene id: 502025:HOCH_RS19800
uniprot id: D0LIC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

502025:HOCH RS26265
gene id: 502025:HOCH_RS26265
uniprot id: D0LXM0
names: Similarity
messages: Belongs to the TPP enzyme family.

502025:HOCH RS21775
gene id: 502025:HOCH_RS21775
uniprot id: D0LNJ7
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS14720
gene id: 502025:HOCH_RS14720
uniprot id: D0LR11
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS33995
gene id: 502025:HOCH_RS33995
uniprot id: D0LUI3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

502025:HOCH RS09185
gene id: 502025:HOCH_RS09185
uniprot id: D0LYW7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

502025:HOCH RS34755
gene id: 502025:HOCH_RS34755
uniprot id: D0LPF6
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

502025:HOCH RS36985
gene id: 502025:HOCH_RS36985
uniprot id: D0LZG1
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

502025:HOCH RS25920
gene id: 502025:HOCH_RS25920
uniprot id: D0LXF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

502025:HOCH RS08065
gene id: 502025:HOCH_RS08065
uniprot id: D0LWW5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS42115
gene id: 502025:HOCH_RS42115
uniprot id: D0LP86
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

502025:HOCH RS00975
gene id: 502025:HOCH_RS00975
uniprot id: D0LHG8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

502025:HOCH RS08450
gene id: 502025:HOCH_RS08450
uniprot id: D0LXT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

502025:HOCH RS16885
gene id: 502025:HOCH_RS16885
uniprot id: D0LVA5
names: Similarity
messages: Belongs to the threonine aldolase family.

502025:HOCH RS31300
gene id: 502025:HOCH_RS31300
uniprot id: D0LNU2
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

502025:HOCH RS08960
gene id: 502025:HOCH_RS08960
uniprot id: D0LY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

502025:HOCH RS19645
gene id: 502025:HOCH_RS19645
uniprot id: D0LIB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

502025:HOCH RS26160
gene id: 502025:HOCH_RS26160
uniprot id: D0LXJ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

502025:HOCH RS21785
gene id: 502025:HOCH_RS21785
uniprot id: D0LNJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

502025:HOCH RS07155
gene id: 502025:HOCH_RS07155
uniprot id: D0LVQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS12285
gene id: 502025:HOCH_RS12285
uniprot id: D0LKK1
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS19230
gene id: 502025:HOCH_RS19230
uniprot id: D0LZE4
names: Similarity
messages: Belongs to the peptidase S13 family.

502025:HOCH RS02840
gene id: 502025:HOCH_RS02840
uniprot id: D0LLI5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS08210
gene id: 502025:HOCH_RS08210
uniprot id: D0LWZ5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

502025:HOCH RS32465
gene id: 502025:HOCH_RS32465
uniprot id: D0LRL2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

502025:HOCH RS07980
gene id: 502025:HOCH_RS07980
uniprot id: D0LWU8
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

502025:HOCH RS01080
gene id: 502025:HOCH_RS01080
uniprot id: D0LHI9
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

502025:HOCH RS12050
gene id: 502025:HOCH_RS12050
uniprot id: D0LKF3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS19715
gene id: 502025:HOCH_RS19715
uniprot id: D0LIC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

502025:HOCH RS11840
gene id: 502025:HOCH_RS11840
uniprot id: D0LJB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

502025:HOCH RS09400
gene id: 502025:HOCH_RS09400
uniprot id: D0LZ08
names: Similarity
messages: Belongs to the disproportionating enzyme family.

502025:HOCH RS18575
gene id: 502025:HOCH_RS18575
uniprot id: D0LYD1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

502025:HOCH RS28890
gene id: 502025:HOCH_RS28890
uniprot id: D0LHE3
names: Biotechnology
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A minor component of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMCs with a molecular mass of 6.5 MDa. This protein does not form stacked pseudohexamers in the BMC. There are 20 BMC-T pseudohexamers per BMC, composed of mixed BMC-T1, BMC-T2 and BMC-T3. The shell facets are 20-30 Angstroms thick, with 1 of BMC-T trimers protruding to the exterior.
messages: Artificial BMCs can be made in E.coli by expressing (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) or (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)). Cargo proteins can be targeted to this BMC (PubMed:24631000, PubMed:28642439). BMC-H can be modified to place its N- and C-terminii in the interior of the shell (called CPH). Fusing proteins to the C-terminus of CPH allows targeting of cargo proteins to the lumen of the organelle composed of CPH, BMC-P and BMC-T1 (PubMed:31075444). This subunit has been modifed to bind a 4Fe-4S center, which is the first step in conferring electron-transfer function to BMCs (PubMed:26704697).
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.
messages: Homotrimerizes to form a pseudohexamer (PubMed:28642439, PubMed:30833088, PubMed:26704697). Unlike its paralogs BMC-T2 and BMC-T3, the pseudohexamers do not stack. The concave side faces outward, with the N- and C-terminii exposed to the cytoplasm (PubMed:28642439, PubMed:30833088).
messages: Required for efficient BMC formation; when deleted from an artificial operon (Hoch_5815, Hoch_5812, Hoch_3341, Hoch_5816, Hoch_4425, Hoch_4426, Hoch_5814) being expressed in E.coli, a >10-fold decrease in BMC shells is seen.
messages: These proteins have 2 BMC domains which evolve independently of each other, giving the term pseudohexamer to the trimerized subunit. Although the homotrimer fills the approximate space of a BMC hexamer protein, the BMC-T trimers are more compact. Their universal presence in BMCs indicates their structural importance. The homohexamers form pores of at least 5 Angstroms in diameter.

502025:HOCH RS16125
gene id: 502025:HOCH_RS16125
uniprot id: D0LTV1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

502025:HOCH RS16095
gene id: 502025:HOCH_RS16095
uniprot id: D0LTU5
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS33500
gene id: 502025:HOCH_RS33500
uniprot id: D0LT72
names: Subcellular Location Annotation
messages: Nucleus

502025:HOCH RS21875
gene id: 502025:HOCH_RS21875
uniprot id: D0LNL8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

502025:HOCH RS12060
gene id: 502025:HOCH_RS12060
uniprot id: D0LKF5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

502025:HOCH RS24045
gene id: 502025:HOCH_RS24045
uniprot id: D0LPN2
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

502025:HOCH RS09535
gene id: 502025:HOCH_RS09535
uniprot id: D0LZ34
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

502025:HOCH RS24305
gene id: 502025:HOCH_RS24305
uniprot id: D0LU32
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

502025:HOCH RS35860
gene id: 502025:HOCH_RS35860
uniprot id: D0LTN4
names: Similarity
messages: Belongs to the CutA family.

502025:HOCH RS27250
gene id: 502025:HOCH_RS27250
uniprot id: D0LZI8
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

502025:HOCH RS26225
gene id: 502025:HOCH_RS26225
uniprot id: D0LXL2
names: Similarity
messages: Belongs to the GST superfamily. NadH family.

502025:HOCH RS19595
gene id: 502025:HOCH_RS19595
uniprot id: D0LIA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

502025:HOCH RS32850
gene id: 502025:HOCH_RS32850
uniprot id: D0LRT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

502025:HOCH RS30135
gene id: 502025:HOCH_RS30135
uniprot id: D0LL42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

502025:HOCH RS07135
gene id: 502025:HOCH_RS07135
uniprot id: D0LVP8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

502025:HOCH RS11020
gene id: 502025:HOCH_RS11020
uniprot id: D0LHW6
names: Similarity
messages: Belongs to the FBPase class 2 family.

502025:HOCH RS31470
gene id: 502025:HOCH_RS31470
uniprot id: D0LNX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

502025:HOCH RS27160
gene id: 502025:HOCH_RS27160
uniprot id: D0LZH0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

502025:HOCH RS19585
gene id: 502025:HOCH_RS19585
uniprot id: D0LI98
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

502025:HOCH RS35780
gene id: 502025:HOCH_RS35780
uniprot id: D0LR61
names: Similarity
messages: Belongs to the peptidase S8 family.

502025:HOCH RS18455
gene id: 502025:HOCH_RS18455
uniprot id: D0LYA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

502025:HOCH RS07125
gene id: 502025:HOCH_RS07125
uniprot id: D0LVP6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

502025:HOCH RS08050
gene id: 502025:HOCH_RS08050
uniprot id: D0LWW2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

502025:HOCH RS22105
gene id: 502025:HOCH_RS22105
uniprot id: D0LNR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS17825
gene id: 502025:HOCH_RS17825
uniprot id: D0LX93
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

502025:HOCH RS33955
gene id: 502025:HOCH_RS33955
uniprot id: D0LUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

502025:HOCH RS16200
gene id: 502025:HOCH_RS16200
uniprot id: D0LTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

502025:HOCH RS24735
gene id: 502025:HOCH_RS24735
uniprot id: D0LVB8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS21585
gene id: 502025:HOCH_RS21585
uniprot id: D0LMF8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

502025:HOCH RS28975
gene id: 502025:HOCH_RS28975
uniprot id: D0LIE9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

502025:HOCH RS27270
gene id: 502025:HOCH_RS27270
uniprot id: D0LZJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS18905
gene id: 502025:HOCH_RS18905
uniprot id: D0LZ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

502025:HOCH RS11130
gene id: 502025:HOCH_RS11130
uniprot id: D0LHY8
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS32795
gene id: 502025:HOCH_RS32795
uniprot id: D0LRS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

502025:HOCH RS01470
gene id: 502025:HOCH_RS01470
uniprot id: D0LHR7
names: Similarity
messages: Belongs to the universal stress protein A family.

502025:HOCH RS33525
gene id: 502025:HOCH_RS33525
uniprot id: D0LT77
names: Similarity
messages: Belongs to the group II decarboxylase family.

502025:HOCH RS15320
gene id: 502025:HOCH_RS15320
uniprot id: D0LSD6
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS22080
gene id: 502025:HOCH_RS22080
uniprot id: D0LNQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

502025:HOCH RS00020
gene id: 502025:HOCH_RS00020
uniprot id: D0LFL2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

502025:HOCH RS33990
gene id: 502025:HOCH_RS33990
uniprot id: D0LUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

502025:HOCH RS15750
gene id: 502025:HOCH_RS15750
uniprot id: D0LTM5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

502025:HOCH RS30415
gene id: 502025:HOCH_RS30415
uniprot id: D0LL98
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS08770
gene id: 502025:HOCH_RS08770
uniprot id: D0LY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS13260
gene id: 502025:HOCH_RS13260
uniprot id: D0LN64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

502025:HOCH RS01835
gene id: 502025:HOCH_RS01835
uniprot id: D0LIX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

502025:HOCH RS30670
gene id: 502025:HOCH_RS30670
uniprot id: D0LLF0
names: Subunit
messages: Homodimer.

502025:HOCH RS00060
gene id: 502025:HOCH_RS00060
uniprot id: D0LFM0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS09885
gene id: 502025:HOCH_RS09885
uniprot id: D0LFX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Belongs to the TonB-dependent receptor family.
messages: Cell inner membrane
messages: Cell outer membrane
messages: Membrane

502025:HOCH RS29960
gene id: 502025:HOCH_RS29960
uniprot id: D0LJZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

502025:HOCH RS15495
gene id: 502025:HOCH_RS15495
uniprot id: D0LSH0
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

502025:HOCH RS15960
gene id: 502025:HOCH_RS15960
uniprot id: D0LTR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

502025:HOCH RS30205
gene id: 502025:HOCH_RS30205
uniprot id: D0LL56
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

502025:HOCH RS04240
gene id: 502025:HOCH_RS04240
uniprot id: D0LPC4
names: Similarity
messages: Belongs to the peptidase S8 family.

502025:HOCH RS19920
gene id: 502025:HOCH_RS19920
uniprot id: D0LJG6
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS36630
gene id: 502025:HOCH_RS36630
uniprot id: D0LRI3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

502025:HOCH RS21480
gene id: 502025:HOCH_RS21480
uniprot id: D0LMD7
names: Similarity
messages: Belongs to the cytochrome P450 family.

502025:HOCH RS30140
gene id: 502025:HOCH_RS30140
uniprot id: D0LL43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

502025:HOCH RS08410
gene id: 502025:HOCH_RS08410
uniprot id: D0LXS7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

502025:HOCH RS21055
gene id: 502025:HOCH_RS21055
uniprot id: D0LM52
names: Subcellular Location Annotation
messages: Membrane

502025:HOCH RS09385
gene id: 502025:HOCH_RS09385
uniprot id: D0LZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

502025:HOCH RS24705
gene id: 502025:HOCH_RS24705
uniprot id: D0LVB4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

502025:HOCH RS13865
gene id: 502025:HOCH_RS13865
uniprot id: D0LPJ7
names: Function
messages: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.

502025:HOCH RS17115
gene id: 502025:HOCH_RS17115
uniprot id: D0LW59
names: Cofactor
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.

502025:HOCH RS32320
gene id: 502025:HOCH_RS32320
uniprot id: D0LQG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

502025:HOCH RS08030
gene id: 502025:HOCH_RS08030
uniprot id: D0LWV8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

502025:HOCH RS00705
gene id: 502025:HOCH_RS00705
uniprot id: D0LGN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

502025:HOCH RS23035
gene id: 502025:HOCH_RS23035
uniprot id: D0LRC0
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

502025:HOCH RS17320
gene id: 502025:HOCH_RS17320
uniprot id: D0LWA0
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

502025:HOCH RS32970
gene id: 502025:HOCH_RS32970
uniprot id: D0LRW2
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

502025:HOCH RS25760
gene id: 502025:HOCH_RS25760
uniprot id: D0LWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

502025:HOCH RS30595
gene id: 502025:HOCH_RS30595
uniprot id: D0LLD5
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.