498761:HM1 RS11410
gene id: 498761:HM1_RS11410
uniprot id: B0TAJ7
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

498761:HM1 RS11440
gene id: 498761:HM1_RS11440
uniprot id: B0TAK3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

498761:HM1 RS08775
gene id: 498761:HM1_RS08775
uniprot id: B0TFS7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

498761:HM1 RS09300
gene id: 498761:HM1_RS09300
uniprot id: B0TGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

498761:HM1 RS08820
gene id: 498761:HM1_RS08820
uniprot id: B0TFT8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

498761:HM1 RS07575
gene id: 498761:HM1_RS07575
uniprot id: B0TE56
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

498761:HM1 RS02275
gene id: 498761:HM1_RS02275
uniprot id: B0TEI9
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

498761:HM1 RS02415
gene id: 498761:HM1_RS02415
uniprot id: B0TEF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

498761:HM1 RS12030
gene id: 498761:HM1_RS12030
uniprot id: B0TBF7
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

498761:HM1 RS09565
gene id: 498761:HM1_RS09565
uniprot id: B0TGR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

498761:HM1 RS02640
gene id: 498761:HM1_RS02640
uniprot id: B0TDW5
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS06555
gene id: 498761:HM1_RS06555
uniprot id: B0TCB1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS12530
gene id: 498761:HM1_RS12530
uniprot id: B0TC12
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS08705
gene id: 498761:HM1_RS08705
uniprot id: B0TFR3
names: Similarity
messages: Belongs to the UPF0735 family.

498761:HM1 RS10005
gene id: 498761:HM1_RS10005
uniprot id: B0TH92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

498761:HM1 RS04440
gene id: 498761:HM1_RS04440
uniprot id: B0TA35
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

498761:HM1 RS09270
gene id: 498761:HM1_RS09270
uniprot id: B0TGB9
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS12820
gene id: 498761:HM1_RS12820
uniprot id: B0TCG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

498761:HM1 RS03740
gene id: 498761:HM1_RS03740
uniprot id: B0THI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GmhB family.
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS11860
gene id: 498761:HM1_RS11860
uniprot id: B0TBB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

498761:HM1 RS10250
gene id: 498761:HM1_RS10250
uniprot id: B0THE2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

498761:HM1 RS07795
gene id: 498761:HM1_RS07795
uniprot id: B0TEQ2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

498761:HM1 RS13775
gene id: 498761:HM1_RS13775
uniprot id: B0TDK7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

498761:HM1 RS06350
gene id: 498761:HM1_RS06350
uniprot id: B0TC70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

498761:HM1 RS02725
gene id: 498761:HM1_RS02725
uniprot id: B0TDU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

498761:HM1 RS09370
gene id: 498761:HM1_RS09370
uniprot id: B0TGD9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS08285
gene id: 498761:HM1_RS08285
uniprot id: B0TF82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

498761:HM1 RS04685
gene id: 498761:HM1_RS04685
uniprot id: B0TA86
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

498761:HM1 RS03960
gene id: 498761:HM1_RS03960
uniprot id: B0THN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

498761:HM1 RS09470
gene id: 498761:HM1_RS09470
uniprot id: B0TGP4
names: Similarity
messages: Belongs to the UPF0237 family.

498761:HM1 RS02540
gene id: 498761:HM1_RS02540
uniprot id: B0TDY8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

498761:HM1 RS06365
gene id: 498761:HM1_RS06365
uniprot id: B0TC73
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

498761:HM1 RS03005
gene id: 498761:HM1_RS03005
uniprot id: B0TGK4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

498761:HM1 RS08300
gene id: 498761:HM1_RS08300
uniprot id: B0TF85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS10165
gene id: 498761:HM1_RS10165
uniprot id: B0THC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

498761:HM1 RS03675
gene id: 498761:HM1_RS03675
uniprot id: B0THG8
names: Function
names: Similarity
names: Subunit
messages: APS kinase catalyzes the synthesis of activated sulfate.
messages: Belongs to the APS kinase family.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Catalyzes the synthesis of activated sulfate.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

498761:HM1 RS06440
gene id: 498761:HM1_RS06440
uniprot id: B0TC88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

498761:HM1 RS06935
gene id: 498761:HM1_RS06935
uniprot id: B0TCS1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

498761:HM1 RS03235
gene id: 498761:HM1_RS03235
uniprot id: B0TGZ1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

498761:HM1 RS04335
gene id: 498761:HM1_RS04335
uniprot id: B0TID6
names: Similarity
messages: Belongs to the EamA transporter family.

498761:HM1 RS10850
gene id: 498761:HM1_RS10850
uniprot id: B0TII1
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

498761:HM1 RS05570
gene id: 498761:HM1_RS05570
uniprot id: B0TB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

498761:HM1 RS14760
gene id: 498761:HM1_RS14760
uniprot id: B0TBH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

498761:HM1 RS05850
gene id: 498761:HM1_RS05850
uniprot id: B0TBN0
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

498761:HM1 RS00645
gene id: 498761:HM1_RS00645
uniprot id: B0TD62
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS11765
gene id: 498761:HM1_RS11765
uniprot id: B0TB06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

498761:HM1 RS12295
gene id: 498761:HM1_RS12295
uniprot id: B0TBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

498761:HM1 RS02790
gene id: 498761:HM1_RS02790
uniprot id: B0TDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS08200
gene id: 498761:HM1_RS08200
uniprot id: B0TF65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

498761:HM1 RS06315
gene id: 498761:HM1_RS06315
uniprot id: B0TC63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS13850
gene id: 498761:HM1_RS13850
uniprot id: B0TDM6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

498761:HM1 RS11310
gene id: 498761:HM1_RS11310
uniprot id: B0TAG8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

498761:HM1 RS12620
gene id: 498761:HM1_RS12620
uniprot id: B0TC33
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

498761:HM1 RS10745
gene id: 498761:HM1_RS10745
uniprot id: B0TIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

498761:HM1 RS07255
gene id: 498761:HM1_RS07255
uniprot id: B0TDC9
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

498761:HM1 RS05100
gene id: 498761:HM1_RS05100
uniprot id: B0TAQ7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS09885
gene id: 498761:HM1_RS09885
uniprot id: B0TH66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

498761:HM1 RS00255
gene id: 498761:HM1_RS00255
uniprot id: B0TI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

498761:HM1 RS13300
gene id: 498761:HM1_RS13300
uniprot id: B0TCY3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS11120
gene id: 498761:HM1_RS11120
uniprot id: B0TAC7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

498761:HM1 RS09990
gene id: 498761:HM1_RS09990
uniprot id: B0TH88
names: Similarity
messages: Belongs to the UPF0102 family.

498761:HM1 RS01375
gene id: 498761:HM1_RS01375
uniprot id: B0TFJ7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

498761:HM1 RS12355
gene id: 498761:HM1_RS12355
uniprot id: B0TBX4
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS10160
gene id: 498761:HM1_RS10160
uniprot id: B0THC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

498761:HM1 RS14725
gene id: 498761:HM1_RS14725
uniprot id: B0TIL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

498761:HM1 RS03190
gene id: 498761:HM1_RS03190
uniprot id: B0TGY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

498761:HM1 RS11920
gene id: 498761:HM1_RS11920
uniprot id: B0TBD3
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

498761:HM1 RS06295
gene id: 498761:HM1_RS06295
uniprot id: B0TC59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

498761:HM1 RS11105
gene id: 498761:HM1_RS11105
uniprot id: B0TAC4
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS13160
gene id: 498761:HM1_RS13160
uniprot id: B0TCU9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS05675
gene id: 498761:HM1_RS05675
uniprot id: B0TBA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

498761:HM1 RS13475
gene id: 498761:HM1_RS13475
uniprot id: B0TD18
names: Similarity
messages: Belongs to the peptidase S14 family.

498761:HM1 RS06145
gene id: 498761:HM1_RS06145
uniprot id: B0TBU1
names: Similarity
messages: Belongs to the ycf81 family.

498761:HM1 RS08060
gene id: 498761:HM1_RS08060
uniprot id: B0TEV4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

498761:HM1 RS09515
gene id: 498761:HM1_RS09515
uniprot id: B0TGQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

498761:HM1 RS12500
gene id: 498761:HM1_RS12500
uniprot id: B0TC05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

498761:HM1 RS04545
gene id: 498761:HM1_RS04545
uniprot id: B0TA55
names: Similarity
messages: Belongs to the peptidase S16 family.

498761:HM1 RS03665
gene id: 498761:HM1_RS03665
uniprot id: B0THG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

498761:HM1 RS12175
gene id: 498761:HM1_RS12175
uniprot id: B0TBJ2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

498761:HM1 RS08110
gene id: 498761:HM1_RS08110
uniprot id: B0TEW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS08850
gene id: 498761:HM1_RS08850
uniprot id: B0TFU4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

498761:HM1 RS14150
gene id: 498761:HM1_RS14150
uniprot id: B0TED4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

498761:HM1 RS02215
gene id: 498761:HM1_RS02215
uniprot id: B0TEK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

498761:HM1 RS12035
gene id: 498761:HM1_RS12035
uniprot id: B0TBF8
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

498761:HM1 RS03010
gene id: 498761:HM1_RS03010
uniprot id: B0TGK5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

498761:HM1 RS04325
gene id: 498761:HM1_RS04325
uniprot id: B0TID4
names: Similarity
messages: Belongs to the ThiD family.

498761:HM1 RS04085
gene id: 498761:HM1_RS04085
uniprot id: B0TI78
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

498761:HM1 RS12600
gene id: 498761:HM1_RS12600
uniprot id: B0TC28
names: Similarity
messages: Belongs to the sigma-70 factor family.

498761:HM1 RS04850
gene id: 498761:HM1_RS04850
uniprot id: B0TAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

498761:HM1 RS00030
gene id: 498761:HM1_RS00030
uniprot id: B0THW0
names: Similarity
messages: Belongs to the TelA family.

498761:HM1 RS10170
gene id: 498761:HM1_RS10170
uniprot id: B0THC6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

498761:HM1 RS07230
gene id: 498761:HM1_RS07230
uniprot id: B0TDC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

498761:HM1 RS11270
gene id: 498761:HM1_RS11270
uniprot id: B0TAF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

498761:HM1 RS11675
gene id: 498761:HM1_RS11675
uniprot id: B0TAY6
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS01460
gene id: 498761:HM1_RS01460
uniprot id: B0TFI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

498761:HM1 RS07725
gene id: 498761:HM1_RS07725
uniprot id: B0TE90
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS04900
gene id: 498761:HM1_RS04900
uniprot id: B0TAL9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

498761:HM1 RS12955
gene id: 498761:HM1_RS12955
uniprot id: B0TCH2
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

498761:HM1 RS00425
gene id: 498761:HM1_RS00425
uniprot id: B0TI48
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

498761:HM1 RS03775
gene id: 498761:HM1_RS03775
uniprot id: B0THJ2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

498761:HM1 RS01635
gene id: 498761:HM1_RS01635
uniprot id: B0TFE5
names: Similarity
messages: Belongs to the cytochrome c-552 family.

498761:HM1 RS09995
gene id: 498761:HM1_RS09995
uniprot id: B0TH89
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

498761:HM1 RS06275
gene id: 498761:HM1_RS06275
uniprot id: B0TC55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

498761:HM1 RS09985
gene id: 498761:HM1_RS09985
uniprot id: B0TH87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

498761:HM1 RS04050
gene id: 498761:HM1_RS04050
uniprot id: B0TI71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

498761:HM1 RS06250
gene id: 498761:HM1_RS06250
uniprot id: B0TC53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

498761:HM1 RS14170
gene id: 498761:HM1_RS14170
uniprot id: B0TED9
names: Similarity
messages: Belongs to the GerABKA family.

498761:HM1 RS01355
gene id: 498761:HM1_RS01355
uniprot id: B0TFK4
names: Similarity
messages: Belongs to the leucine-binding protein family.

498761:HM1 RS05830
gene id: 498761:HM1_RS05830
uniprot id: B0TBM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
messages: Homodimer. Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB.

498761:HM1 RS01570
gene id: 498761:HM1_RS01570
uniprot id: B0TFF8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

498761:HM1 RS12170
gene id: 498761:HM1_RS12170
uniprot id: B0TBJ1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

498761:HM1 RS06220
gene id: 498761:HM1_RS06220
uniprot id: B0TC46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

498761:HM1 RS11080
gene id: 498761:HM1_RS11080
uniprot id: B0TAB9
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS10055
gene id: 498761:HM1_RS10055
uniprot id: B0THA3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

498761:HM1 RS06455
gene id: 498761:HM1_RS06455
uniprot id: B0TC91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

498761:HM1 RS01905
gene id: 498761:HM1_RS01905
uniprot id: B0TF04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

498761:HM1 RS06890
gene id: 498761:HM1_RS06890
uniprot id: B0TCR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS08990
gene id: 498761:HM1_RS08990
uniprot id: B0TG59
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

498761:HM1 RS05755
gene id: 498761:HM1_RS05755
uniprot id: B0TBK9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

498761:HM1 RS06090
gene id: 498761:HM1_RS06090
uniprot id: B0TBS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

498761:HM1 RS05855
gene id: 498761:HM1_RS05855
uniprot id: B0TBN1
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

498761:HM1 RS01060
gene id: 498761:HM1_RS01060
uniprot id: B0TG11
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS03945
gene id: 498761:HM1_RS03945
uniprot id: B0THN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

498761:HM1 RS12775
gene id: 498761:HM1_RS12775
uniprot id: B0TCF3
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS14485
gene id: 498761:HM1_RS14485
uniprot id: B0TAU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

498761:HM1 RS09500
gene id: 498761:HM1_RS09500
uniprot id: B0TGQ0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

498761:HM1 RS09210
gene id: 498761:HM1_RS09210
uniprot id: B0TGA7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

498761:HM1 RS02615
gene id: 498761:HM1_RS02615
uniprot id: B0TDX1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

498761:HM1 RS09935
gene id: 498761:HM1_RS09935
uniprot id: B0TH77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

498761:HM1 RS03345
gene id: 498761:HM1_RS03345
uniprot id: B0TH14
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

498761:HM1 RS07885
gene id: 498761:HM1_RS07885
uniprot id: B0TES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS02685
gene id: 498761:HM1_RS02685
uniprot id: B0TDV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

498761:HM1 RS05835
gene id: 498761:HM1_RS05835
uniprot id: B0TBM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BchN/ChlN family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

498761:HM1 RS11170
gene id: 498761:HM1_RS11170
uniprot id: B0TAD8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

498761:HM1 RS13620
gene id: 498761:HM1_RS13620
uniprot id: B0TDH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

498761:HM1 RS09670
gene id: 498761:HM1_RS09670
uniprot id: B0TGT5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

498761:HM1 RS11855
gene id: 498761:HM1_RS11855
uniprot id: B0TBB6
names: Similarity
messages: Belongs to the peptidase S8 family.

498761:HM1 RS11180
gene id: 498761:HM1_RS11180
uniprot id: B0TAE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

498761:HM1 RS14260
gene id: 498761:HM1_RS14260
uniprot id: B0TGH7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

498761:HM1 RS05575
gene id: 498761:HM1_RS05575
uniprot id: B0TB86
names: Similarity
messages: Belongs to the P(II) protein family.

498761:HM1 RS14290
gene id: 498761:HM1_RS14290
uniprot id: B0TFL2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

498761:HM1 RS14305
gene id: 498761:HM1_RS14305
uniprot id: B0TFG0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

498761:HM1 RS09700
gene id: 498761:HM1_RS09700
uniprot id: B0TGU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

498761:HM1 RS09510
gene id: 498761:HM1_RS09510
uniprot id: B0TGQ3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

498761:HM1 RS11590
gene id: 498761:HM1_RS11590
uniprot id: B0TAW6
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

498761:HM1 RS09395
gene id: 498761:HM1_RS09395
uniprot id: B0TGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

498761:HM1 RS02055
gene id: 498761:HM1_RS02055
uniprot id: B0TEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS09260
gene id: 498761:HM1_RS09260
uniprot id: B0TGB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane

498761:HM1 RS12325
gene id: 498761:HM1_RS12325
uniprot id: B0TBW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

498761:HM1 RS10255
gene id: 498761:HM1_RS10255
uniprot id: B0THN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

498761:HM1 RS10565
gene id: 498761:HM1_RS10565
uniprot id: B0THS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

498761:HM1 RS13655
gene id: 498761:HM1_RS13655
uniprot id: B0TDI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddB/RexB type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of AddA and AddB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.

498761:HM1 RS11175
gene id: 498761:HM1_RS11175
uniprot id: B0TAD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

498761:HM1 RS06425
gene id: 498761:HM1_RS06425
uniprot id: B0TC85
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

498761:HM1 RS08515
gene id: 498761:HM1_RS08515
uniprot id: B0TFD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

498761:HM1 RS09805
gene id: 498761:HM1_RS09805
uniprot id: B0TGW3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

498761:HM1 RS04125
gene id: 498761:HM1_RS04125
uniprot id: B0TI88
names: Similarity
messages: Belongs to the RpoE family.

498761:HM1 RS10860
gene id: 498761:HM1_RS10860
uniprot id: B0TII3
names: Similarity
messages: Belongs to the DEAD box helicase family.

498761:HM1 RS11160
gene id: 498761:HM1_RS11160
uniprot id: B0TAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

498761:HM1 RS02985
gene id: 498761:HM1_RS02985
uniprot id: B0TGK0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

498761:HM1 RS10840
gene id: 498761:HM1_RS10840
uniprot id: B0TIH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

498761:HM1 RS10590
gene id: 498761:HM1_RS10590
uniprot id: B0THT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

498761:HM1 RS02655
gene id: 498761:HM1_RS02655
uniprot id: B0TDW2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

498761:HM1 RS09950
gene id: 498761:HM1_RS09950
uniprot id: B0TH80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

498761:HM1 RS01485
gene id: 498761:HM1_RS01485
uniprot id: B0TFH8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

498761:HM1 RS04870
gene id: 498761:HM1_RS04870
uniprot id: B0TAL2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

498761:HM1 RS14780
gene id: 498761:HM1_RS14780
uniprot id: B0TC24
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS06530
gene id: 498761:HM1_RS06530
uniprot id: B0TCA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

498761:HM1 RS05870
gene id: 498761:HM1_RS05870
uniprot id: B0TBN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

498761:HM1 RS07005
gene id: 498761:HM1_RS07005
uniprot id: B0TD74
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS04045
gene id: 498761:HM1_RS04045
uniprot id: B0TI70
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

498761:HM1 RS05630
gene id: 498761:HM1_RS05630
uniprot id: B0TB98
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

498761:HM1 RS10130
gene id: 498761:HM1_RS10130
uniprot id: B0THB8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS03060
gene id: 498761:HM1_RS03060
uniprot id: B0TGL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

498761:HM1 RS08135
gene id: 498761:HM1_RS08135
uniprot id: B0TF57
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS11485
gene id: 498761:HM1_RS11485
uniprot id: B0TAV1
names: Similarity
messages: Belongs to the PduL family.

498761:HM1 RS11940
gene id: 498761:HM1_RS11940
uniprot id: B0TBD7
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS00455
gene id: 498761:HM1_RS00455
uniprot id: B0TD31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

498761:HM1 RS07410
gene id: 498761:HM1_RS07410
uniprot id: B0TE16
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

498761:HM1 RS07675
gene id: 498761:HM1_RS07675
uniprot id: B0TE80
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS08895
gene id: 498761:HM1_RS08895
uniprot id: B0TFV5
names: Similarity
messages: Belongs to the EamA transporter family.

498761:HM1 RS08795
gene id: 498761:HM1_RS08795
uniprot id: B0TFT2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

498761:HM1 RS06325
gene id: 498761:HM1_RS06325
uniprot id: B0TC65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

498761:HM1 RS00965
gene id: 498761:HM1_RS00965
uniprot id: B0TG22
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS08710
gene id: 498761:HM1_RS08710
uniprot id: B0TFR4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

498761:HM1 RS02185
gene id: 498761:HM1_RS02185
uniprot id: B0TEK8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

498761:HM1 RS05410
gene id: 498761:HM1_RS05410
uniprot id: B0TB49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS04175
gene id: 498761:HM1_RS04175
uniprot id: B0TIA0
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

498761:HM1 RS10175
gene id: 498761:HM1_RS10175
uniprot id: B0THC7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

498761:HM1 RS04120
gene id: 498761:HM1_RS04120
uniprot id: B0TI86
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS10975
gene id: 498761:HM1_RS10975
uniprot id: B0TIK6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

498761:HM1 RS03910
gene id: 498761:HM1_RS03910
uniprot id: B0THM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS10035
gene id: 498761:HM1_RS10035
uniprot id: B0TH99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

498761:HM1 RS06320
gene id: 498761:HM1_RS06320
uniprot id: B0TC64
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

498761:HM1 RS03000
gene id: 498761:HM1_RS03000
uniprot id: B0TGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

498761:HM1 RS01430
gene id: 498761:HM1_RS01430
uniprot id: B0TFI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

498761:HM1 RS05880
gene id: 498761:HM1_RS05880
uniprot id: B0TBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

498761:HM1 RS03950
gene id: 498761:HM1_RS03950
uniprot id: B0THN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

498761:HM1 RS05780
gene id: 498761:HM1_RS05780
uniprot id: B0TBL5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family. PetB subfamily.
messages: Binds 2 heme b groups non-covalently with two histidine residues as axial ligands.
messages: Binds one heme group covalently by a single cysteine link with no axial amino acid ligand. This heme was named heme ci.
messages: Cell membrane
messages: Component of the cytochrome bc complex which donates electrons to the photosynthetic reaction center.
messages: Heme 1 (or BH or b566) is high-potential and absorbs at about 566 nm, and heme 2 (or BL or b562) is low-potential and absorbs at about 562 nm.
messages: The subunits of the cytochrome bc complex are a Rieske Fe-S protein (PetC), cytochrome b6 (PetB), subunit IV (PetD), and a diheme cytochrome c (PetX).

498761:HM1 RS09795
gene id: 498761:HM1_RS09795
uniprot id: B0TGW1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

498761:HM1 RS04760
gene id: 498761:HM1_RS04760
uniprot id: B0TAA3
names: Similarity
messages: Belongs to the leucine-binding protein family.

498761:HM1 RS13965
gene id: 498761:HM1_RS13965
uniprot id: B0TE94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

498761:HM1 RS11665
gene id: 498761:HM1_RS11665
uniprot id: B0TAY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

498761:HM1 RS00305
gene id: 498761:HM1_RS00305
uniprot id: B0TI21
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS11430
gene id: 498761:HM1_RS11430
uniprot id: B0TAK1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS08055
gene id: 498761:HM1_RS08055
uniprot id: B0TEV3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

498761:HM1 RS01030
gene id: 498761:HM1_RS01030
uniprot id: B0TG17
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS16110
gene id: 498761:HM1_RS16110
uniprot id: B0TI66
names: Similarity
messages: Belongs to the LacAB/RpiB family.

498761:HM1 RS03280
gene id: 498761:HM1_RS03280
uniprot id: B0TH01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

498761:HM1 RS03275
gene id: 498761:HM1_RS03275
uniprot id: B0TH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

498761:HM1 RS06540
gene id: 498761:HM1_RS06540
uniprot id: B0TCA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

498761:HM1 RS09290
gene id: 498761:HM1_RS09290
uniprot id: B0TGC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS09360
gene id: 498761:HM1_RS09360
uniprot id: B0TGD7
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

498761:HM1 RS03860
gene id: 498761:HM1_RS03860
uniprot id: B0THL2
names: Similarity
messages: Belongs to the peptidase S8 family.

498761:HM1 RS08400
gene id: 498761:HM1_RS08400
uniprot id: B0TFA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

498761:HM1 RS10935
gene id: 498761:HM1_RS10935
uniprot id: B0TIJ8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

498761:HM1 RS09125
gene id: 498761:HM1_RS09125
uniprot id: B0TG88
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

498761:HM1 RS03035
gene id: 498761:HM1_RS03035
uniprot id: B0TGL0
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

498761:HM1 RS13195
gene id: 498761:HM1_RS13195
uniprot id: B0TCV6
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

498761:HM1 RS09645
gene id: 498761:HM1_RS09645
uniprot id: A0A173G7H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

498761:HM1 RS01135
gene id: 498761:HM1_RS01135
uniprot id: B0TFZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

498761:HM1 RS02245
gene id: 498761:HM1_RS02245
uniprot id: B0TEJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

498761:HM1 RS11235
gene id: 498761:HM1_RS11235
uniprot id: B0TAF0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

498761:HM1 RS09630
gene id: 498761:HM1_RS09630
uniprot id: B0TGS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

498761:HM1 RS00495
gene id: 498761:HM1_RS00495
uniprot id: B0TD39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

498761:HM1 RS14645
gene id: 498761:HM1_RS14645
uniprot id: B0TF69
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

498761:HM1 RS14790
gene id: 498761:HM1_RS14790
uniprot id: B0TCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

498761:HM1 RS04565
gene id: 498761:HM1_RS04565
uniprot id: B0TA59
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

498761:HM1 RS07270
gene id: 498761:HM1_RS07270
uniprot id: B0TDD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

498761:HM1 RS07570
gene id: 498761:HM1_RS07570
uniprot id: B0TE55
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

498761:HM1 RS03900
gene id: 498761:HM1_RS03900
uniprot id: B0THM0
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

498761:HM1 RS09760
gene id: 498761:HM1_RS09760
uniprot id: B0TGV4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

498761:HM1 RS05275
gene id: 498761:HM1_RS05275
uniprot id: B0TB20
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

498761:HM1 RS02695
gene id: 498761:HM1_RS02695
uniprot id: B0TDV2
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS09455
gene id: 498761:HM1_RS09455
uniprot id: B0TGP1
names: Similarity
messages: Belongs to the UPF0235 family.

498761:HM1 RS11780
gene id: 498761:HM1_RS11780
uniprot id: B0TB10
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

498761:HM1 RS06230
gene id: 498761:HM1_RS06230
uniprot id: B0TC49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

498761:HM1 RS05970
gene id: 498761:HM1_RS05970
uniprot id: B0TBQ4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

498761:HM1 RS05430
gene id: 498761:HM1_RS05430
uniprot id: B0TB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

498761:HM1 RS09880
gene id: 498761:HM1_RS09880
uniprot id: B0TH65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

498761:HM1 RS09855
gene id: 498761:HM1_RS09855
uniprot id: B0TH59
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS09710
gene id: 498761:HM1_RS09710
uniprot id: B0TGU3
names: Similarity
messages: Belongs to the asp23 family.

498761:HM1 RS05155
gene id: 498761:HM1_RS05155
uniprot id: B0TAS0
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

498761:HM1 RS09610
gene id: 498761:HM1_RS09610
uniprot id: B0TGS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

498761:HM1 RS05895
gene id: 498761:HM1_RS05895
uniprot id: B0TBN9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

498761:HM1 RS04165
gene id: 498761:HM1_RS04165
uniprot id: B0TI97
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

498761:HM1 RS13880
gene id: 498761:HM1_RS13880
uniprot id: B0TDN3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

498761:HM1 RS08970
gene id: 498761:HM1_RS08970
uniprot id: B0TG56
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

498761:HM1 RS11065
gene id: 498761:HM1_RS11065
uniprot id: B0TIM5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

498761:HM1 RS06520
gene id: 498761:HM1_RS06520
uniprot id: B0TCA4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

498761:HM1 RS05930
gene id: 498761:HM1_RS05930
uniprot id: B0TBP6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

498761:HM1 RS08390
gene id: 498761:HM1_RS08390
uniprot id: B0TFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

498761:HM1 RS05785
gene id: 498761:HM1_RS05785
uniprot id: B0TBL6
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS02120
gene id: 498761:HM1_RS02120
uniprot id: B0TEM0
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

498761:HM1 RS10875
gene id: 498761:HM1_RS10875
uniprot id: B0TII6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

498761:HM1 RS07015
gene id: 498761:HM1_RS07015
uniprot id: B0TD76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS10600
gene id: 498761:HM1_RS10600
uniprot id: B0THT5
names: Similarity
messages: Belongs to the peptidase S14 family.

498761:HM1 RS09505
gene id: 498761:HM1_RS09505
uniprot id: B0TGQ1
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

498761:HM1 RS06675
gene id: 498761:HM1_RS06675
uniprot id: B0TCL3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

498761:HM1 RS11055
gene id: 498761:HM1_RS11055
uniprot id: B0TIM3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

498761:HM1 RS14710
gene id: 498761:HM1_RS14710
uniprot id: B0THB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

498761:HM1 RS06430
gene id: 498761:HM1_RS06430
uniprot id: B0TC86
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

498761:HM1 RS10110
gene id: 498761:HM1_RS10110
uniprot id: B0THB4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

498761:HM1 RS09690
gene id: 498761:HM1_RS09690
uniprot id: B0TGT9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

498761:HM1 RS13115
gene id: 498761:HM1_RS13115
uniprot id: B0TCT9
names: Similarity
messages: Belongs to the peptidase S14 family.

498761:HM1 RS10305
gene id: 498761:HM1_RS10305
uniprot id: B0THP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

498761:HM1 RS09725
gene id: 498761:HM1_RS09725
uniprot id: B0TGU7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

498761:HM1 RS06655
gene id: 498761:HM1_RS06655
uniprot id: B0TCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

498761:HM1 RS01220
gene id: 498761:HM1_RS01220
uniprot id: B0TFX5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

498761:HM1 RS06865
gene id: 498761:HM1_RS06865
uniprot id: B0TCQ6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS11240
gene id: 498761:HM1_RS11240
uniprot id: B0TAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS07635
gene id: 498761:HM1_RS07635
uniprot id: B0TE71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

498761:HM1 RS06725
gene id: 498761:HM1_RS06725
uniprot id: B0TCM6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

498761:HM1 RS03165
gene id: 498761:HM1_RS03165
uniprot id: B0TGX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

498761:HM1 RS09230
gene id: 498761:HM1_RS09230
uniprot id: B0TGB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

498761:HM1 RS06375
gene id: 498761:HM1_RS06375
uniprot id: B0TC75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS14850
gene id: 498761:HM1_RS14850
uniprot id: B0TEB4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

498761:HM1 RS05480
gene id: 498761:HM1_RS05480
uniprot id: B0TB64
names: Similarity
messages: Belongs to the hexokinase family.

498761:HM1 RS06210
gene id: 498761:HM1_RS06210
uniprot id: B0TC44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

498761:HM1 RS03175
gene id: 498761:HM1_RS03175
uniprot id: B0TGX9
names: Similarity
messages: Belongs to the peptidase S41A family.

498761:HM1 RS04255
gene id: 498761:HM1_RS04255
uniprot id: B0TIB7
names: Similarity
messages: Belongs to the glutamate synthase family.

498761:HM1 RS13355
gene id: 498761:HM1_RS13355
uniprot id: B0TCZ4
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

498761:HM1 RS08315
gene id: 498761:HM1_RS08315
uniprot id: B0TF88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS13780
gene id: 498761:HM1_RS13780
uniprot id: B0TDK8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

498761:HM1 RS06780
gene id: 498761:HM1_RS06780
uniprot id: B0TCN7
names: Similarity
messages: Belongs to the UPF0047 family.

498761:HM1 RS12415
gene id: 498761:HM1_RS12415
uniprot id: B0TBY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

498761:HM1 RS05375
gene id: 498761:HM1_RS05375
uniprot id: B0TB42
names: Similarity
messages: Belongs to the Lgt family.

498761:HM1 RS05285
gene id: 498761:HM1_RS05285
uniprot id: B0TB22
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

498761:HM1 RS09600
gene id: 498761:HM1_RS09600
uniprot id: B0TGS2
names: Similarity
messages: Belongs to the RemA family.

498761:HM1 RS06390
gene id: 498761:HM1_RS06390
uniprot id: B0TC78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

498761:HM1 RS09120
gene id: 498761:HM1_RS09120
uniprot id: B0TG87
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS12180
gene id: 498761:HM1_RS12180
uniprot id: B0TBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

498761:HM1 RS04670
gene id: 498761:HM1_RS04670
uniprot id: B0TA83
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

498761:HM1 RS06565
gene id: 498761:HM1_RS06565
uniprot id: B0TCB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

498761:HM1 RS01885
gene id: 498761:HM1_RS01885
uniprot id: B0TF09
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

498761:HM1 RS06360
gene id: 498761:HM1_RS06360
uniprot id: B0TC72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

498761:HM1 RS06880
gene id: 498761:HM1_RS06880
uniprot id: B0TCQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

498761:HM1 RS06610
gene id: 498761:HM1_RS06610
uniprot id: B0TCJ5
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

498761:HM1 RS12045
gene id: 498761:HM1_RS12045
uniprot id: B0TBG0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

498761:HM1 RS06015
gene id: 498761:HM1_RS06015
uniprot id: B0TBR5
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS01115
gene id: 498761:HM1_RS01115
uniprot id: B0TFZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

498761:HM1 RS07010
gene id: 498761:HM1_RS07010
uniprot id: B0TD75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

498761:HM1 RS09835
gene id: 498761:HM1_RS09835
uniprot id: B0TGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

498761:HM1 RS12390
gene id: 498761:HM1_RS12390
uniprot id: B0TBY1
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

498761:HM1 RS06400
gene id: 498761:HM1_RS06400
uniprot id: B0TC80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

498761:HM1 RS06370
gene id: 498761:HM1_RS06370
uniprot id: B0TC74
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS06445
gene id: 498761:HM1_RS06445
uniprot id: B0TC89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). May be able to interact with more than 1 S component at a time (By similarity).
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

498761:HM1 RS04515
gene id: 498761:HM1_RS04515
uniprot id: B0TA51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

498761:HM1 RS05940
gene id: 498761:HM1_RS05940
uniprot id: B0TBP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

498761:HM1 RS01980
gene id: 498761:HM1_RS01980
uniprot id: B0TEY7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS06225
gene id: 498761:HM1_RS06225
uniprot id: B0TC48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

498761:HM1 RS13955
gene id: 498761:HM1_RS13955
uniprot id: B0TE92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

498761:HM1 RS01260
gene id: 498761:HM1_RS01260
uniprot id: B0TFM5
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

498761:HM1 RS09100
gene id: 498761:HM1_RS09100
uniprot id: B0TG83
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS12105
gene id: 498761:HM1_RS12105
uniprot id: B0TBH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

498761:HM1 RS04855
gene id: 498761:HM1_RS04855
uniprot id: B0TAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

498761:HM1 RS05915
gene id: 498761:HM1_RS05915
uniprot id: B0TBP3
names: Similarity
messages: Belongs to the DHPS family.

498761:HM1 RS10680
gene id: 498761:HM1_RS10680
uniprot id: B0THV1
names: Similarity
messages: Belongs to the glutamine synthetase family.

498761:HM1 RS10270
gene id: 498761:HM1_RS10270
uniprot id: B0THN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

498761:HM1 RS12780
gene id: 498761:HM1_RS12780
uniprot id: B0TCF4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS08255
gene id: 498761:HM1_RS08255
uniprot id: B0TF76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

498761:HM1 RS03895
gene id: 498761:HM1_RS03895
uniprot id: B0THL9
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

498761:HM1 RS09590
gene id: 498761:HM1_RS09590
uniprot id: B0TGS0
names: Similarity
messages: Belongs to the YicC/YloC family.

498761:HM1 RS14115
gene id: 498761:HM1_RS14115
uniprot id: B0TEC6
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

498761:HM1 RS05165
gene id: 498761:HM1_RS05165
uniprot id: B0TAS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

498761:HM1 RS04345
gene id: 498761:HM1_RS04345
uniprot id: B0TID8
names: Similarity
messages: Belongs to the AAA ATPase family.

498761:HM1 RS06355
gene id: 498761:HM1_RS06355
uniprot id: B0TC71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

498761:HM1 RS02015
gene id: 498761:HM1_RS02015
uniprot id: B0TEX8
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

498761:HM1 RS01660
gene id: 498761:HM1_RS01660
uniprot id: B0TF54
names: Cofactor
messages: Binds 1 zinc ion per subunit.

498761:HM1 RS07845
gene id: 498761:HM1_RS07845
uniprot id: B0TER3
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

498761:HM1 RS10505
gene id: 498761:HM1_RS10505
uniprot id: B0THR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

498761:HM1 RS12505
gene id: 498761:HM1_RS12505
uniprot id: B0TC06
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

498761:HM1 RS14265
gene id: 498761:HM1_RS14265
uniprot id: B0TG16
names: Function
names: Subcellular Location Annotation
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Membrane

498761:HM1 RS14110
gene id: 498761:HM1_RS14110
uniprot id: B0TEC5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

498761:HM1 RS01300
gene id: 498761:HM1_RS01300
uniprot id: B0TFL5
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS05625
gene id: 498761:HM1_RS05625
uniprot id: B0TB97
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).

498761:HM1 RS09850
gene id: 498761:HM1_RS09850
uniprot id: B0TH58
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

498761:HM1 RS06120
gene id: 498761:HM1_RS06120
uniprot id: B0TBT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

498761:HM1 RS07880
gene id: 498761:HM1_RS07880
uniprot id: B0TES1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

498761:HM1 RS01365
gene id: 498761:HM1_RS01365
uniprot id: B0TFK1
names: Similarity
messages: Belongs to the asparagine synthetase family.

498761:HM1 RS06115
gene id: 498761:HM1_RS06115
uniprot id: B0TBT4
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

498761:HM1 RS08685
gene id: 498761:HM1_RS08685
uniprot id: B0TFR0
names: Similarity
messages: Belongs to the type IA topoisomerase family.

498761:HM1 RS01155
gene id: 498761:HM1_RS01155
uniprot id: B0TFY8
names: Similarity
messages: Belongs to the UPF0297 family.

498761:HM1 RS02630
gene id: 498761:HM1_RS02630
uniprot id: B0TDW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

498761:HM1 RS06535
gene id: 498761:HM1_RS06535
uniprot id: B0TCA7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

498761:HM1 RS08830
gene id: 498761:HM1_RS08830
uniprot id: B0TFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

498761:HM1 RS08945
gene id: 498761:HM1_RS08945
uniprot id: B0TFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

498761:HM1 RS09140
gene id: 498761:HM1_RS09140
uniprot id: B0TG92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

498761:HM1 RS10910
gene id: 498761:HM1_RS10910
uniprot id: B0TIJ3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS05035
gene id: 498761:HM1_RS05035
uniprot id: B0TAP3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.

498761:HM1 RS10645
gene id: 498761:HM1_RS10645
uniprot id: B0THU4
names: Similarity
messages: Belongs to the agmatine deiminase family.

498761:HM1 RS13670
gene id: 498761:HM1_RS13670
uniprot id: B0TDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

498761:HM1 RS13590
gene id: 498761:HM1_RS13590
uniprot id: B0TDG7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

498761:HM1 RS11230
gene id: 498761:HM1_RS11230
uniprot id: B0TAE9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

498761:HM1 RS12210
gene id: 498761:HM1_RS12210
uniprot id: B0TBK1
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS14125
gene id: 498761:HM1_RS14125
uniprot id: B0TEC8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

498761:HM1 RS12150
gene id: 498761:HM1_RS12150
uniprot id: B0TBI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxA family. PdxA2 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate.
messages: Homodimer.

498761:HM1 RS06420
gene id: 498761:HM1_RS06420
uniprot id: B0TC84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

498761:HM1 RS02625
gene id: 498761:HM1_RS02625
uniprot id: B0TDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

498761:HM1 RS14930
gene id: 498761:HM1_RS14930
uniprot id: B0TCD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

498761:HM1 RS08845
gene id: 498761:HM1_RS08845
uniprot id: B0TFU3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

498761:HM1 RS02530
gene id: 498761:HM1_RS02530
uniprot id: B0TDZ0
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

498761:HM1 RS06975
gene id: 498761:HM1_RS06975
uniprot id: B0TD66
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS12605
gene id: 498761:HM1_RS12605
uniprot id: B0TC29
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

498761:HM1 RS03995
gene id: 498761:HM1_RS03995
uniprot id: B0TI60
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

498761:HM1 RS08085
gene id: 498761:HM1_RS08085
uniprot id: B0TEW1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

498761:HM1 RS07165
gene id: 498761:HM1_RS07165
uniprot id: B0TDB0
names: Similarity
messages: Belongs to the EamA transporter family.

498761:HM1 RS05905
gene id: 498761:HM1_RS05905
uniprot id: B0TBP1
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

498761:HM1 RS11460
gene id: 498761:HM1_RS11460
uniprot id: B0TAU6
names: Function
names: Similarity
messages: Belongs to the BshC family.
messages: Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.

498761:HM1 RS02800
gene id: 498761:HM1_RS02800
uniprot id: B0TDS6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

498761:HM1 RS09955
gene id: 498761:HM1_RS09955
uniprot id: B0TH81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

498761:HM1 RS11135
gene id: 498761:HM1_RS11135
uniprot id: B0TAD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

498761:HM1 RS10585
gene id: 498761:HM1_RS10585
uniprot id: B0THT1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

498761:HM1 RS03955
gene id: 498761:HM1_RS03955
uniprot id: B0THN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

498761:HM1 RS06110
gene id: 498761:HM1_RS06110
uniprot id: B0TBT2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

498761:HM1 RS04960
gene id: 498761:HM1_RS04960
uniprot id: B0TAN1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

498761:HM1 RS16455
gene id: 498761:HM1_RS16455
uniprot id: B0THB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

498761:HM1 RS08465
gene id: 498761:HM1_RS08465
uniprot id: B0TFC2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

498761:HM1 RS14050
gene id: 498761:HM1_RS14050
uniprot id: B0TEA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS06905
gene id: 498761:HM1_RS06905
uniprot id: B0TCR4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS14140
gene id: 498761:HM1_RS14140
uniprot id: B0TED1
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

498761:HM1 RS03215
gene id: 498761:HM1_RS03215
uniprot id: B0TGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

498761:HM1 RS10010
gene id: 498761:HM1_RS10010
uniprot id: B0TH93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

498761:HM1 RS05015
gene id: 498761:HM1_RS05015
uniprot id: B0TAN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

498761:HM1 RS07955
gene id: 498761:HM1_RS07955
uniprot id: B0TET1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

498761:HM1 RS02955
gene id: 498761:HM1_RS02955
uniprot id: B0TGJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

498761:HM1 RS13680
gene id: 498761:HM1_RS13680
uniprot id: B0TDI6
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS08910
gene id: 498761:HM1_RS08910
uniprot id: B0TFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

498761:HM1 RS09275
gene id: 498761:HM1_RS09275
uniprot id: B0TGC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS06755
gene id: 498761:HM1_RS06755
uniprot id: B0TCN2
names: Similarity
messages: Belongs to the HupF/HypC family.

498761:HM1 RS10235
gene id: 498761:HM1_RS10235
uniprot id: B0THD9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS03640
gene id: 498761:HM1_RS03640
uniprot id: B0THG1
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

498761:HM1 RS01085
gene id: 498761:HM1_RS01085
uniprot id: B0TG05
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

498761:HM1 RS00745
gene id: 498761:HM1_RS00745
uniprot id: B0TGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

498761:HM1 RS05330
gene id: 498761:HM1_RS05330
uniprot id: B0TB33
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

498761:HM1 RS14980
gene id: 498761:HM1_RS14980
uniprot id: B0TG43
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

498761:HM1 RS06550
gene id: 498761:HM1_RS06550
uniprot id: B0TCB0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

498761:HM1 RS02355
gene id: 498761:HM1_RS02355
uniprot id: B0TEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

498761:HM1 RS12090
gene id: 498761:HM1_RS12090
uniprot id: B0TBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

498761:HM1 RS11990
gene id: 498761:HM1_RS11990
uniprot id: B0TBE8
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

498761:HM1 RS01495
gene id: 498761:HM1_RS01495
uniprot id: B0TFH5
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS11965
gene id: 498761:HM1_RS11965
uniprot id: B0TBE3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS08825
gene id: 498761:HM1_RS08825
uniprot id: B0TFT9
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS02000
gene id: 498761:HM1_RS02000
uniprot id: B0TEY1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

498761:HM1 RS04095
gene id: 498761:HM1_RS04095
uniprot id: B0TI80
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS08965
gene id: 498761:HM1_RS08965
uniprot id: B0TG55
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

498761:HM1 RS09325
gene id: 498761:HM1_RS09325
uniprot id: B0TGD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

498761:HM1 RS11610
gene id: 498761:HM1_RS11610
uniprot id: B0TAX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

498761:HM1 RS16435
gene id: 498761:HM1_RS16435
uniprot id: B0TF74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

498761:HM1 RS08480
gene id: 498761:HM1_RS08480
uniprot id: B0TFC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

498761:HM1 RS07605
gene id: 498761:HM1_RS07605
uniprot id: B0TE66
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS06285
gene id: 498761:HM1_RS06285
uniprot id: B0TC57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS06155
gene id: 498761:HM1_RS06155
uniprot id: B0TBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS10225
gene id: 498761:HM1_RS10225
uniprot id: B0THD7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

498761:HM1 RS05065
gene id: 498761:HM1_RS05065
uniprot id: B0TAP9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

498761:HM1 RS02590
gene id: 498761:HM1_RS02590
uniprot id: B0TDX7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS02450
gene id: 498761:HM1_RS02450
uniprot id: B0TEF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS07790
gene id: 498761:HM1_RS07790
uniprot id: B0TEP9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

498761:HM1 RS12480
gene id: 498761:HM1_RS12480
uniprot id: B0TC01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

498761:HM1 RS10145
gene id: 498761:HM1_RS10145
uniprot id: B0THC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

498761:HM1 RS05645
gene id: 498761:HM1_RS05645
uniprot id: B0TBA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

498761:HM1 RS03615
gene id: 498761:HM1_RS03615
uniprot id: B0THF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

498761:HM1 RS01600
gene id: 498761:HM1_RS01600
uniprot id: B0TFF2
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

498761:HM1 RS09490
gene id: 498761:HM1_RS09490
uniprot id: B0TGP8
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

498761:HM1 RS07175
gene id: 498761:HM1_RS07175
uniprot id: B0TDB2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS09475
gene id: 498761:HM1_RS09475
uniprot id: B0TGP5
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

498761:HM1 RS09940
gene id: 498761:HM1_RS09940
uniprot id: B0TH78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

498761:HM1 RS03185
gene id: 498761:HM1_RS03185
uniprot id: B0TGY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

498761:HM1 RS13865
gene id: 498761:HM1_RS13865
uniprot id: B0TDM9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

498761:HM1 RS00250
gene id: 498761:HM1_RS00250
uniprot id: B0TI09
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

498761:HM1 RS04215
gene id: 498761:HM1_RS04215
uniprot id: B0TIA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS10640
gene id: 498761:HM1_RS10640
uniprot id: B0THU3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

498761:HM1 RS02210
gene id: 498761:HM1_RS02210
uniprot id: B0TEK1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

498761:HM1 RS09840
gene id: 498761:HM1_RS09840
uniprot id: B0TH56
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

498761:HM1 RS01890
gene id: 498761:HM1_RS01890
uniprot id: B0TF08
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

498761:HM1 RS13770
gene id: 498761:HM1_RS13770
uniprot id: B0TDK6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

498761:HM1 RS02140
gene id: 498761:HM1_RS02140
uniprot id: B0TEL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

498761:HM1 RS00365
gene id: 498761:HM1_RS00365
uniprot id: B0TI35
names: Similarity
names: Subunit
messages: Belongs to the MtrB family.
messages: Oligomer of 11 identical subunits arranged in doughnut-like structure.

498761:HM1 RS09160
gene id: 498761:HM1_RS09160
uniprot id: B0TG97
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS01960
gene id: 498761:HM1_RS01960
uniprot id: B0TEZ1
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS09635
gene id: 498761:HM1_RS09635
uniprot id: B0TGS9
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

498761:HM1 RS06475
gene id: 498761:HM1_RS06475
uniprot id: B0TC95
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

498761:HM1 RS00315
gene id: 498761:HM1_RS00315
uniprot id: B0TI23
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

498761:HM1 RS13890
gene id: 498761:HM1_RS13890
uniprot id: B0TDN5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

498761:HM1 RS09265
gene id: 498761:HM1_RS09265
uniprot id: B0TGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

498761:HM1 RS07720
gene id: 498761:HM1_RS07720
uniprot id: B0TE89
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS00300
gene id: 498761:HM1_RS00300
uniprot id: B0TI20
names: Similarity
messages: Belongs to the P(II) protein family.

498761:HM1 RS10065
gene id: 498761:HM1_RS10065
uniprot id: B0THA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

498761:HM1 RS13280
gene id: 498761:HM1_RS13280
uniprot id: B0TCX9
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

498761:HM1 RS10675
gene id: 498761:HM1_RS10675
uniprot id: B0THV0
names: Similarity
messages: Belongs to the MecA family.

498761:HM1 RS08715
gene id: 498761:HM1_RS08715
uniprot id: B0TFR5
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

498761:HM1 RS09255
gene id: 498761:HM1_RS09255
uniprot id: B0TGB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

498761:HM1 RS06160
gene id: 498761:HM1_RS06160
uniprot id: B0TC34
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

498761:HM1 RS06840
gene id: 498761:HM1_RS06840
uniprot id: B0TCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

498761:HM1 RS02255
gene id: 498761:HM1_RS02255
uniprot id: B0TEJ3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

498761:HM1 RS05860
gene id: 498761:HM1_RS05860
uniprot id: B0TBN2
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

498761:HM1 RS06255
gene id: 498761:HM1_RS06255
uniprot id: B0TC54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

498761:HM1 RS05075
gene id: 498761:HM1_RS05075
uniprot id: B0TAQ1
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

498761:HM1 RS14755
gene id: 498761:HM1_RS14755
uniprot id: B0TBE7
names: Similarity
messages: Belongs to the AAA ATPase family.

498761:HM1 RS09430
gene id: 498761:HM1_RS09430
uniprot id: B0TGN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

498761:HM1 RS10865
gene id: 498761:HM1_RS10865
uniprot id: B0TII4
names: Similarity
messages: Belongs to the UPF0749 family.

498761:HM1 RS08940
gene id: 498761:HM1_RS08940
uniprot id: B0TFW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

498761:HM1 RS09875
gene id: 498761:HM1_RS09875
uniprot id: B0TH64
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

498761:HM1 RS06245
gene id: 498761:HM1_RS06245
uniprot id: B0TC52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

498761:HM1 RS11725
gene id: 498761:HM1_RS11725
uniprot id: B0TAZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

498761:HM1 RS04040
gene id: 498761:HM1_RS04040
uniprot id: B0TI69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

498761:HM1 RS10150
gene id: 498761:HM1_RS10150
uniprot id: B0THC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

498761:HM1 RS02650
gene id: 498761:HM1_RS02650
uniprot id: B0TDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

498761:HM1 RS09890
gene id: 498761:HM1_RS09890
uniprot id: B0TH67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

498761:HM1 RS05110
gene id: 498761:HM1_RS05110
uniprot id: B0TAQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

498761:HM1 RS02230
gene id: 498761:HM1_RS02230
uniprot id: B0TEJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

498761:HM1 RS00370
gene id: 498761:HM1_RS00370
uniprot id: B0TI36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

498761:HM1 RS05085
gene id: 498761:HM1_RS05085
uniprot id: B0TAQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

498761:HM1 RS00340
gene id: 498761:HM1_RS00340
uniprot id: B0TI28
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

498761:HM1 RS06545
gene id: 498761:HM1_RS06545
uniprot id: B0TCA9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

498761:HM1 RS02565
gene id: 498761:HM1_RS02565
uniprot id: B0TDY3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

498761:HM1 RS00900
gene id: 498761:HM1_RS00900
uniprot id: B0TG35
names: Similarity
messages: Belongs to the GSP E family.

498761:HM1 RS06405
gene id: 498761:HM1_RS06405
uniprot id: B0TC81
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

498761:HM1 RS05950
gene id: 498761:HM1_RS05950
uniprot id: B0TBQ0
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

498761:HM1 RS04450
gene id: 498761:HM1_RS04450
uniprot id: B0TA38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

498761:HM1 RS04530
gene id: 498761:HM1_RS04530
uniprot id: B0TA52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

498761:HM1 RS04330
gene id: 498761:HM1_RS04330
uniprot id: B0TID5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SspH family.
messages: Spore core

498761:HM1 RS08640
gene id: 498761:HM1_RS08640
uniprot id: B0TFP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

498761:HM1 RS07530
gene id: 498761:HM1_RS07530
uniprot id: B0TE46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

498761:HM1 RS07840
gene id: 498761:HM1_RS07840
uniprot id: B0TER2
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

498761:HM1 RS07965
gene id: 498761:HM1_RS07965
uniprot id: B0TET3
names: Similarity
messages: Belongs to the PspA/IM30 family.

498761:HM1 RS08975
gene id: 498761:HM1_RS08975
uniprot id: B0TG57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

498761:HM1 RS02265
gene id: 498761:HM1_RS02265
uniprot id: B0TEJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

498761:HM1 RS05040
gene id: 498761:HM1_RS05040
uniprot id: B0TAP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

498761:HM1 RS05335
gene id: 498761:HM1_RS05335
uniprot id: B0TB34
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

498761:HM1 RS11150
gene id: 498761:HM1_RS11150
uniprot id: B0TAD4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

498761:HM1 RS03025
gene id: 498761:HM1_RS03025
uniprot id: B0TGK8
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

498761:HM1 RS03555
gene id: 498761:HM1_RS03555
uniprot id: B0THE4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

498761:HM1 RS11790
gene id: 498761:HM1_RS11790
uniprot id: A0A173G7H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS07650
gene id: 498761:HM1_RS07650
uniprot id: B0TE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

498761:HM1 RS04265
gene id: 498761:HM1_RS04265
uniprot id: B0TIB9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

498761:HM1 RS04860
gene id: 498761:HM1_RS04860
uniprot id: B0TAL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

498761:HM1 RS07200
gene id: 498761:HM1_RS07200
uniprot id: B0TDB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

498761:HM1 RS08225
gene id: 498761:HM1_RS08225
uniprot id: B0TF70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

498761:HM1 RS10280
gene id: 498761:HM1_RS10280
uniprot id: B0THP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS07145
gene id: 498761:HM1_RS07145
uniprot id: B0TDA6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

498761:HM1 RS01550
gene id: 498761:HM1_RS01550
uniprot id: B0TFG3
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

498761:HM1 RS01415
gene id: 498761:HM1_RS01415
uniprot id: B0TFI9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

498761:HM1 RS04535
gene id: 498761:HM1_RS04535
uniprot id: B0TA53
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

498761:HM1 RS10040
gene id: 498761:HM1_RS10040
uniprot id: B0THA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

498761:HM1 RS07215
gene id: 498761:HM1_RS07215
uniprot id: B0TDC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

498761:HM1 RS06745
gene id: 498761:HM1_RS06745
uniprot id: B0TCN0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

498761:HM1 RS05135
gene id: 498761:HM1_RS05135
uniprot id: B0TAR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

498761:HM1 RS04010
gene id: 498761:HM1_RS04010
uniprot id: B0TI63
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

498761:HM1 RS15590
gene id: 498761:HM1_RS15590
uniprot id: B0THQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS03435
gene id: 498761:HM1_RS03435
uniprot id: B0TH32
names: Similarity
messages: Belongs to the polysaccharide synthase family.

498761:HM1 RS03680
gene id: 498761:HM1_RS03680
uniprot id: B0THG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

498761:HM1 RS04035
gene id: 498761:HM1_RS04035
uniprot id: B0TI68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

498761:HM1 RS03905
gene id: 498761:HM1_RS03905
uniprot id: B0THM1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

498761:HM1 RS09450
gene id: 498761:HM1_RS09450
uniprot id: B0TGP0
names: Subcellular Location Annotation
messages: Cytoplasm

498761:HM1 RS08080
gene id: 498761:HM1_RS08080
uniprot id: B0TEV9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

498761:HM1 RS11325
gene id: 498761:HM1_RS11325
uniprot id: B0TAH2
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

498761:HM1 RS04570
gene id: 498761:HM1_RS04570
uniprot id: B0TA60
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

498761:HM1 RS07240
gene id: 498761:HM1_RS07240
uniprot id: B0TDC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

498761:HM1 RS02240
gene id: 498761:HM1_RS02240
uniprot id: B0TEJ6
names: Similarity
messages: Belongs to the TlyA family.

498761:HM1 RS01345
gene id: 498761:HM1_RS01345
uniprot id: B0TFK6
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS06910
gene id: 498761:HM1_RS06910
uniprot id: B0TCR5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

498761:HM1 RS02370
gene id: 498761:HM1_RS02370
uniprot id: B0TEG8
names: Similarity
messages: Belongs to the peptidase U62 family.

498761:HM1 RS02460
gene id: 498761:HM1_RS02460
uniprot id: B0TEE9
names: Similarity
messages: Belongs to the GSP E family.

498761:HM1 RS01225
gene id: 498761:HM1_RS01225
uniprot id: B0TFX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

498761:HM1 RS00280
gene id: 498761:HM1_RS00280
uniprot id: B0TI15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

498761:HM1 RS13040
gene id: 498761:HM1_RS13040
uniprot id: B0TCI9
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS04825
gene id: 498761:HM1_RS04825
uniprot id: B0TAB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

498761:HM1 RS10630
gene id: 498761:HM1_RS10630
uniprot id: B0THU1
names: Similarity
messages: Belongs to the UPF0234 family.

498761:HM1 RS00350
gene id: 498761:HM1_RS00350
uniprot id: B0TI32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

498761:HM1 RS08460
gene id: 498761:HM1_RS08460
uniprot id: B0TFB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

498761:HM1 RS14515
gene id: 498761:HM1_RS14515
uniprot id: B0TBB0
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS00915
gene id: 498761:HM1_RS00915
uniprot id: B0TG32
names: Similarity
messages: Belongs to the peptidase A24 family.

498761:HM1 RS11155
gene id: 498761:HM1_RS11155
uniprot id: B0TAD5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

498761:HM1 RS12215
gene id: 498761:HM1_RS12215
uniprot id: B0TBK2
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS07265
gene id: 498761:HM1_RS07265
uniprot id: B0TDD2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

498761:HM1 RS05925
gene id: 498761:HM1_RS05925
uniprot id: B0TBP5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

498761:HM1 RS02115
gene id: 498761:HM1_RS02115
uniprot id: B0TEM1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

498761:HM1 RS01410
gene id: 498761:HM1_RS01410
uniprot id: B0TFJ0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

498761:HM1 RS08860
gene id: 498761:HM1_RS08860
uniprot id: B0TFU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

498761:HM1 RS12695
gene id: 498761:HM1_RS12695
uniprot id: B0TCD5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

498761:HM1 RS14120
gene id: 498761:HM1_RS14120
uniprot id: B0TEC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

498761:HM1 RS04840
gene id: 498761:HM1_RS04840
uniprot id: B0TAK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

498761:HM1 RS09090
gene id: 498761:HM1_RS09090
uniprot id: B0TG81
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS13875
gene id: 498761:HM1_RS13875
uniprot id: B0TDN1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

498761:HM1 RS13410
gene id: 498761:HM1_RS13410
uniprot id: B0TD05
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

498761:HM1 RS13230
gene id: 498761:HM1_RS13230
uniprot id: B0TCW6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

498761:HM1 RS09870
gene id: 498761:HM1_RS09870
uniprot id: B0TH63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

498761:HM1 RS05370
gene id: 498761:HM1_RS05370
uniprot id: B0TB41
names: Similarity
messages: Belongs to the peptidase S8 family.

498761:HM1 RS00285
gene id: 498761:HM1_RS00285
uniprot id: B0TI16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

498761:HM1 RS03975
gene id: 498761:HM1_RS03975
uniprot id: B0TI55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(1), b'(1) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta, b and b' chains.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

498761:HM1 RS10190
gene id: 498761:HM1_RS10190
uniprot id: B0THD0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

498761:HM1 RS13690
gene id: 498761:HM1_RS13690
uniprot id: B0TDI8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS09735
gene id: 498761:HM1_RS09735
uniprot id: B0TGU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

498761:HM1 RS09750
gene id: 498761:HM1_RS09750
uniprot id: B0TGV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

498761:HM1 RS06410
gene id: 498761:HM1_RS06410
uniprot id: B0TC82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

498761:HM1 RS03230
gene id: 498761:HM1_RS03230
uniprot id: B0TGZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS01265
gene id: 498761:HM1_RS01265
uniprot id: B0TFM4
names: Similarity
messages: Belongs to the UPF0045 family.

498761:HM1 RS06480
gene id: 498761:HM1_RS06480
uniprot id: B0TC96
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

498761:HM1 RS02580
gene id: 498761:HM1_RS02580
uniprot id: B0TDX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

498761:HM1 RS06845
gene id: 498761:HM1_RS06845
uniprot id: B0TCQ1
names: Similarity
messages: Belongs to the MotB family.

498761:HM1 RS09310
gene id: 498761:HM1_RS09310
uniprot id: B0TGC7
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

498761:HM1 RS02470
gene id: 498761:HM1_RS02470
uniprot id: B0TEE7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

498761:HM1 RS12265
gene id: 498761:HM1_RS12265
uniprot id: B0TBV3
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

498761:HM1 RS14665
gene id: 498761:HM1_RS14665
uniprot id: B0TFP3
names: Similarity
messages: Belongs to the peptidase S41A family.

498761:HM1 RS07860
gene id: 498761:HM1_RS07860
uniprot id: B0TER7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

498761:HM1 RS10730
gene id: 498761:HM1_RS10730
uniprot id: B0TIF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

498761:HM1 RS12385
gene id: 498761:HM1_RS12385
uniprot id: B0TBY0
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

498761:HM1 RS12135
gene id: 498761:HM1_RS12135
uniprot id: B0TBI1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS13885
gene id: 498761:HM1_RS13885
uniprot id: B0TDN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

498761:HM1 RS14610
gene id: 498761:HM1_RS14610
uniprot id: B0TE50
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS10000
gene id: 498761:HM1_RS10000
uniprot id: B0TH91
names: Similarity
messages: Belongs to the DprA/Smf family.

498761:HM1 RS09810
gene id: 498761:HM1_RS09810
uniprot id: B0TGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

498761:HM1 RS14420
gene id: 498761:HM1_RS14420
uniprot id: B0THJ9
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

498761:HM1 RS00485
gene id: 498761:HM1_RS00485
uniprot id: B0TD37
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

498761:HM1 RS03100
gene id: 498761:HM1_RS03100
uniprot id: B0TGM7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS07900
gene id: 498761:HM1_RS07900
uniprot id: B0TES6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

498761:HM1 RS10095
gene id: 498761:HM1_RS10095
uniprot id: B0THB1
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

498761:HM1 RS08215
gene id: 498761:HM1_RS08215
uniprot id: B0TF68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

498761:HM1 RS06765
gene id: 498761:HM1_RS06765
uniprot id: B0TCN4
names: Similarity
messages: Belongs to the HypE family.

498761:HM1 RS11250
gene id: 498761:HM1_RS11250
uniprot id: B0TAF3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

498761:HM1 RS06335
gene id: 498761:HM1_RS06335
uniprot id: B0TC67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS12690
gene id: 498761:HM1_RS12690
uniprot id: B0TCD4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

498761:HM1 RS12525
gene id: 498761:HM1_RS12525
uniprot id: B0TC11
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

498761:HM1 RS09830
gene id: 498761:HM1_RS09830
uniprot id: B0TGW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

498761:HM1 RS09535
gene id: 498761:HM1_RS09535
uniprot id: B0TGQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

498761:HM1 RS06215
gene id: 498761:HM1_RS06215
uniprot id: B0TC45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

498761:HM1 RS04950
gene id: 498761:HM1_RS04950
uniprot id: B0TAM9
names: Similarity
messages: Belongs to the leucine-binding protein family.

498761:HM1 RS01785
gene id: 498761:HM1_RS01785
uniprot id: B0TF31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS02475
gene id: 498761:HM1_RS02475
uniprot id: B0TEE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

498761:HM1 RS01100
gene id: 498761:HM1_RS01100
uniprot id: B0TG02
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

498761:HM1 RS02145
gene id: 498761:HM1_RS02145
uniprot id: B0TEL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

498761:HM1 RS10985
gene id: 498761:HM1_RS10985
uniprot id: B0TIK8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

498761:HM1 RS12155
gene id: 498761:HM1_RS12155
uniprot id: B0TBI9
names: Function
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4-hydroxy-L-threonine, with lower efficiency.

498761:HM1 RS08725
gene id: 498761:HM1_RS08725
uniprot id: B0TFR7
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

498761:HM1 RS11265
gene id: 498761:HM1_RS11265
uniprot id: B0TAF7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

498761:HM1 RS08765
gene id: 498761:HM1_RS08765
uniprot id: B0TFS5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

498761:HM1 RS12315
gene id: 498761:HM1_RS12315
uniprot id: B0TBW5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

498761:HM1 RS06920
gene id: 498761:HM1_RS06920
uniprot id: B0TCR8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

498761:HM1 RS10825
gene id: 498761:HM1_RS10825
uniprot id: B0TIH6
names: Similarity
messages: Belongs to the histone deacetylase family.

498761:HM1 RS12285
gene id: 498761:HM1_RS12285
uniprot id: B0TBV7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

498761:HM1 RS01250
gene id: 498761:HM1_RS01250
uniprot id: B0TFW9
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

498761:HM1 RS06095
gene id: 498761:HM1_RS06095
uniprot id: B0TBS9
names: Similarity
messages: Belongs to the CtsR family.

498761:HM1 RS09975
gene id: 498761:HM1_RS09975
uniprot id: B0TH85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

498761:HM1 RS01280
gene id: 498761:HM1_RS01280
uniprot id: B0TFM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
messages: Homodimer.

498761:HM1 RS12650
gene id: 498761:HM1_RS12650
uniprot id: B0TCC6
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

498761:HM1 RS00245
gene id: 498761:HM1_RS00245
uniprot id: B0TI08
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

498761:HM1 RS06730
gene id: 498761:HM1_RS06730
uniprot id: B0TCM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

498761:HM1 RS05025
gene id: 498761:HM1_RS05025
uniprot id: B0TAP1
names: Similarity
messages: Belongs to the P(II) protein family.

498761:HM1 RS01615
gene id: 498761:HM1_RS01615
uniprot id: B0TFE9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

498761:HM1 RS08295
gene id: 498761:HM1_RS08295
uniprot id: B0TF84
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

498761:HM1 RS05020
gene id: 498761:HM1_RS05020
uniprot id: B0TAP0
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

498761:HM1 RS01160
gene id: 498761:HM1_RS01160
uniprot id: B0TFY7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

498761:HM1 RS08495
gene id: 498761:HM1_RS08495
uniprot id: B0TFC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

498761:HM1 RS10030
gene id: 498761:HM1_RS10030
uniprot id: B0TH97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

498761:HM1 RS08680
gene id: 498761:HM1_RS08680
uniprot id: B0TFQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

498761:HM1 RS07730
gene id: 498761:HM1_RS07730
uniprot id: B0TEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

498761:HM1 RS04765
gene id: 498761:HM1_RS04765
uniprot id: B0TAA4
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

498761:HM1 RS11165
gene id: 498761:HM1_RS11165
uniprot id: B0TAD7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

498761:HM1 RS10995
gene id: 498761:HM1_RS10995
uniprot id: B0TIL0
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

498761:HM1 RS11700
gene id: 498761:HM1_RS11700
uniprot id: B0TAZ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS01875
gene id: 498761:HM1_RS01875
uniprot id: B0TF11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

498761:HM1 RS06290
gene id: 498761:HM1_RS06290
uniprot id: B0TC58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

498761:HM1 RS03540
gene id: 498761:HM1_RS03540
uniprot id: B0TH53
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS02950
gene id: 498761:HM1_RS02950
uniprot id: B0TGJ3
names: Similarity
messages: Belongs to the manganese catalase family.

498761:HM1 RS13860
gene id: 498761:HM1_RS13860
uniprot id: B0TDM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

498761:HM1 RS11095
gene id: 498761:HM1_RS11095
uniprot id: B0TAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS06500
gene id: 498761:HM1_RS06500
uniprot id: B0TCA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

498761:HM1 RS04430
gene id: 498761:HM1_RS04430
uniprot id: B0TA33
names: Similarity
messages: Belongs to the AOR/FOR family.

498761:HM1 RS04820
gene id: 498761:HM1_RS04820
uniprot id: B0TAB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

498761:HM1 RS02155
gene id: 498761:HM1_RS02155
uniprot id: B0TEL3
names: Similarity
messages: Belongs to the DtxR/MntR family.

498761:HM1 RS02200
gene id: 498761:HM1_RS02200
uniprot id: B0TEK4
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS08675
gene id: 498761:HM1_RS08675
uniprot id: B0TFQ7
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

498761:HM1 RS05800
gene id: 498761:HM1_RS05800
uniprot id: B0TBL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

498761:HM1 RS10920
gene id: 498761:HM1_RS10920
uniprot id: B0TIJ5
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

498761:HM1 RS15940
gene id: 498761:HM1_RS15940
uniprot id: B0TD81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

498761:HM1 RS06835
gene id: 498761:HM1_RS06835
uniprot id: B0TCP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Coenzyme A-transferase that converts butyrate to butyryl-CoA.
messages: Cytoplasm

498761:HM1 RS04845
gene id: 498761:HM1_RS04845
uniprot id: B0TAK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

498761:HM1 RS05270
gene id: 498761:HM1_RS05270
uniprot id: B0TB19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

498761:HM1 RS06345
gene id: 498761:HM1_RS06345
uniprot id: B0TC69
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

498761:HM1 RS04130
gene id: 498761:HM1_RS04130
uniprot id: B0TI89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS01480
gene id: 498761:HM1_RS01480
uniprot id: B0TFH9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

498761:HM1 RS05580
gene id: 498761:HM1_RS05580
uniprot id: B0TB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS11980
gene id: 498761:HM1_RS11980
uniprot id: B0TBE6
names: Similarity
messages: Belongs to the glutamate synthase family.

498761:HM1 RS03015
gene id: 498761:HM1_RS03015
uniprot id: B0TGK6
names: Similarity
messages: Belongs to the sigma-54 factor family.

498761:HM1 RS04880
gene id: 498761:HM1_RS04880
uniprot id: B0TAL4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS07640
gene id: 498761:HM1_RS07640
uniprot id: B0TE72
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

498761:HM1 RS04260
gene id: 498761:HM1_RS04260
uniprot id: B0TIB8
names: Similarity
messages: Belongs to the UPF0178 family.

498761:HM1 RS13405
gene id: 498761:HM1_RS13405
uniprot id: B0TD04
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS08570
gene id: 498761:HM1_RS08570
uniprot id: B0TFN4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS10485
gene id: 498761:HM1_RS10485
uniprot id: B0THR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

498761:HM1 RS04875
gene id: 498761:HM1_RS04875
uniprot id: B0TAL3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

498761:HM1 RS05875
gene id: 498761:HM1_RS05875
uniprot id: B0TBN5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS04005
gene id: 498761:HM1_RS04005
uniprot id: B0TI62
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

498761:HM1 RS05325
gene id: 498761:HM1_RS05325
uniprot id: B0TB32
names: Similarity
messages: Belongs to the UPF0166 family.

498761:HM1 RS08785
gene id: 498761:HM1_RS08785
uniprot id: B0TFT0
names: Similarity
messages: Belongs to the hemerythrin family.

498761:HM1 RS10555
gene id: 498761:HM1_RS10555
uniprot id: B0THS5
names: Similarity
messages: Belongs to the peptidase M16 family.

498761:HM1 RS05700
gene id: 498761:HM1_RS05700
uniprot id: B0TBB2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

498761:HM1 RS04105
gene id: 498761:HM1_RS04105
uniprot id: B0TI83
names: Similarity
messages: Belongs to the peptidase S49 family.

498761:HM1 RS08590
gene id: 498761:HM1_RS08590
uniprot id: B0TFN9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS01075
gene id: 498761:HM1_RS01075
uniprot id: B0TG08
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

498761:HM1 RS07825
gene id: 498761:HM1_RS07825
uniprot id: B0TEQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

498761:HM1 RS02300
gene id: 498761:HM1_RS02300
uniprot id: B0TEI3
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

498761:HM1 RS13855
gene id: 498761:HM1_RS13855
uniprot id: B0TDM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

498761:HM1 RS02550
gene id: 498761:HM1_RS02550
uniprot id: B0TDY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

498761:HM1 RS08755
gene id: 498761:HM1_RS08755
uniprot id: B0TFS3
names: Similarity
messages: Belongs to the UbiD family.

498761:HM1 RS09410
gene id: 498761:HM1_RS09410
uniprot id: B0TGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

498761:HM1 RS08470
gene id: 498761:HM1_RS08470
uniprot id: B0TFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS05500
gene id: 498761:HM1_RS05500
uniprot id: B0TB68
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

498761:HM1 RS16125
gene id: 498761:HM1_RS16125
uniprot id: B0TIC1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS01520
gene id: 498761:HM1_RS01520
uniprot id: B0TFG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

498761:HM1 RS13815
gene id: 498761:HM1_RS13815
uniprot id: B0TDL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

498761:HM1 RS09010
gene id: 498761:HM1_RS09010
uniprot id: B0TG62
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

498761:HM1 RS14320
gene id: 498761:HM1_RS14320
uniprot id: B0TF38
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS00860
gene id: 498761:HM1_RS00860
uniprot id: B0TG45
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

498761:HM1 RS06380
gene id: 498761:HM1_RS06380
uniprot id: B0TC76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

498761:HM1 RS12040
gene id: 498761:HM1_RS12040
uniprot id: B0TBF9
names: Similarity
messages: Belongs to the carbamate kinase family.

498761:HM1 RS12235
gene id: 498761:HM1_RS12235
uniprot id: B0TBU7
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS13675
gene id: 498761:HM1_RS13675
uniprot id: B0TDI5
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS04270
gene id: 498761:HM1_RS04270
uniprot id: B0TIC0
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

498761:HM1 RS13545
gene id: 498761:HM1_RS13545
uniprot id: B0TDF9
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS13765
gene id: 498761:HM1_RS13765
uniprot id: B0TDK5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

498761:HM1 RS08780
gene id: 498761:HM1_RS08780
uniprot id: B0TFS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

498761:HM1 RS08370
gene id: 498761:HM1_RS08370
uniprot id: B0TFA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

498761:HM1 RS04905
gene id: 498761:HM1_RS04905
uniprot id: B0TAM0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

498761:HM1 RS00055
gene id: 498761:HM1_RS00055
uniprot id: B0THW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

498761:HM1 RS06190
gene id: 498761:HM1_RS06190
uniprot id: B0TC40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

498761:HM1 RS09520
gene id: 498761:HM1_RS09520
uniprot id: B0TGQ5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

498761:HM1 RS05655
gene id: 498761:HM1_RS05655
uniprot id: B0TBA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

498761:HM1 RS02455
gene id: 498761:HM1_RS02455
uniprot id: B0TEF0
names: Similarity
messages: Belongs to the GSP E family.

498761:HM1 RS04940
gene id: 498761:HM1_RS04940
uniprot id: B0TAM7
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS13790
gene id: 498761:HM1_RS13790
uniprot id: B0TDL0
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

498761:HM1 RS05050
gene id: 498761:HM1_RS05050
uniprot id: B0TAP6
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

498761:HM1 RS07425
gene id: 498761:HM1_RS07425
uniprot id: B0TE19
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS04485
gene id: 498761:HM1_RS04485
uniprot id: B0TA44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS06950
gene id: 498761:HM1_RS06950
uniprot id: B0TCS4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

498761:HM1 RS08635
gene id: 498761:HM1_RS08635
uniprot id: B0TFP8
names: Similarity
messages: Belongs to the TrpF family.

498761:HM1 RS01585
gene id: 498761:HM1_RS01585
uniprot id: B0TFF5
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

498761:HM1 RS11370
gene id: 498761:HM1_RS11370
uniprot id: B0TAI6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS06330
gene id: 498761:HM1_RS06330
uniprot id: B0TC66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

498761:HM1 RS01935
gene id: 498761:HM1_RS01935
uniprot id: B0TEZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

498761:HM1 RS06300
gene id: 498761:HM1_RS06300
uniprot id: B0TC60
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

498761:HM1 RS05105
gene id: 498761:HM1_RS05105
uniprot id: B0TAQ8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

498761:HM1 RS04075
gene id: 498761:HM1_RS04075
uniprot id: B0TI76
names: Similarity
messages: Belongs to the FBPase class 2 family.

498761:HM1 RS02665
gene id: 498761:HM1_RS02665
uniprot id: B0TDW0
names: Similarity
messages: Belongs to the ThiD family.

498761:HM1 RS12485
gene id: 498761:HM1_RS12485
uniprot id: B0TC02
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS06670
gene id: 498761:HM1_RS06670
uniprot id: B0TCL2
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

498761:HM1 RS14770
gene id: 498761:HM1_RS14770
uniprot id: B0TBY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

498761:HM1 RS02935
gene id: 498761:HM1_RS02935
uniprot id: B0TGI9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS13795
gene id: 498761:HM1_RS13795
uniprot id: B0TDL1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

498761:HM1 RS08995
gene id: 498761:HM1_RS08995
uniprot id: B0TG60
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

498761:HM1 RS03125
gene id: 498761:HM1_RS03125
uniprot id: B0TGN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

498761:HM1 RS01540
gene id: 498761:HM1_RS01540
uniprot id: B0TFG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

498761:HM1 RS11140
gene id: 498761:HM1_RS11140
uniprot id: B0TAD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

498761:HM1 RS04060
gene id: 498761:HM1_RS04060
uniprot id: B0TI73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

498761:HM1 RS13000
gene id: 498761:HM1_RS13000
uniprot id: B0TCI1
names: Similarity
messages: Belongs to the peptidase S8 family.

498761:HM1 RS06915
gene id: 498761:HM1_RS06915
uniprot id: B0TCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

498761:HM1 RS09235
gene id: 498761:HM1_RS09235
uniprot id: B0TGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

498761:HM1 RS12495
gene id: 498761:HM1_RS12495
uniprot id: B0TC04
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

498761:HM1 RS01995
gene id: 498761:HM1_RS01995
uniprot id: B0TEY4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

498761:HM1 RS11925
gene id: 498761:HM1_RS11925
uniprot id: B0TBD4
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

498761:HM1 RS10025
gene id: 498761:HM1_RS10025
uniprot id: B0TH96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

498761:HM1 RS06415
gene id: 498761:HM1_RS06415
uniprot id: B0TC83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

498761:HM1 RS09425
gene id: 498761:HM1_RS09425
uniprot id: B0TGN5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

498761:HM1 RS06340
gene id: 498761:HM1_RS06340
uniprot id: B0TC68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

498761:HM1 RS14145
gene id: 498761:HM1_RS14145
uniprot id: B0TED3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

498761:HM1 RS09605
gene id: 498761:HM1_RS09605
uniprot id: B0TGS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

498761:HM1 RS06875
gene id: 498761:HM1_RS06875
uniprot id: B0TCQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

498761:HM1 RS03965
gene id: 498761:HM1_RS03965
uniprot id: B0TI53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

498761:HM1 RS03325
gene id: 498761:HM1_RS03325
uniprot id: B0TH10
names: Similarity
messages: Belongs to the phosphohexose mutase family.

498761:HM1 RS05955
gene id: 498761:HM1_RS05955
uniprot id: B0TBQ1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS09040
gene id: 498761:HM1_RS09040
uniprot id: B0TG69
names: Similarity
messages: Belongs to the HdrA family.

498761:HM1 RS08140
gene id: 498761:HM1_RS08140
uniprot id: B0TF58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

498761:HM1 RS08730
gene id: 498761:HM1_RS08730
uniprot id: B0TFR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

498761:HM1 RS07545
gene id: 498761:HM1_RS07545
uniprot id: B0TE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

498761:HM1 RS11785
gene id: 498761:HM1_RS11785
uniprot id: B0TB11
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

498761:HM1 RS14530
gene id: 498761:HM1_RS14530
uniprot id: B0TBL2
names: PTM
messages: Binds 1 heme c group covalently per subunit.

498761:HM1 RS13435
gene id: 498761:HM1_RS13435
uniprot id: B0TD09
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

498761:HM1 RS11070
gene id: 498761:HM1_RS11070
uniprot id: B0TIM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

498761:HM1 RS07695
gene id: 498761:HM1_RS07695
uniprot id: B0TE84
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

498761:HM1 RS07260
gene id: 498761:HM1_RS07260
uniprot id: B0TDD1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

498761:HM1 RS00635
gene id: 498761:HM1_RS00635
uniprot id: B0TD60
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

498761:HM1 RS09900
gene id: 498761:HM1_RS09900
uniprot id: B0TH69
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

498761:HM1 RS14395
gene id: 498761:HM1_RS14395
uniprot id: B0TH44
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

498761:HM1 RS08335
gene id: 498761:HM1_RS08335
uniprot id: B0TF92
names: Similarity
messages: Belongs to the thioredoxin family.

498761:HM1 RS14065
gene id: 498761:HM1_RS14065
uniprot id: B0TEB2
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS10240
gene id: 498761:HM1_RS10240
uniprot id: B0THE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

498761:HM1 RS11690
gene id: 498761:HM1_RS11690
uniprot id: B0TAY9
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

498761:HM1 RS04540
gene id: 498761:HM1_RS04540
uniprot id: B0TA54
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

498761:HM1 RS02495
gene id: 498761:HM1_RS02495
uniprot id: B0TDZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

498761:HM1 RS12290
gene id: 498761:HM1_RS12290
uniprot id: B0TBV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

498761:HM1 RS07490
gene id: 498761:HM1_RS07490
uniprot id: B0TE36
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

498761:HM1 RS05420
gene id: 498761:HM1_RS05420
uniprot id: B0TB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS04955
gene id: 498761:HM1_RS04955
uniprot id: B0TAN0
names: Similarity
messages: Belongs to the leucine-binding protein family.

498761:HM1 RS07275
gene id: 498761:HM1_RS07275
uniprot id: B0TDD4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

498761:HM1 RS03480
gene id: 498761:HM1_RS03480
uniprot id: B0TH40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

498761:HM1 RS06720
gene id: 498761:HM1_RS06720
uniprot id: B0TCM5
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

498761:HM1 RS09245
gene id: 498761:HM1_RS09245
uniprot id: B0TGB4
names: Similarity
messages: Belongs to the transpeptidase family.

498761:HM1 RS12680
gene id: 498761:HM1_RS12680
uniprot id: B0TCD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

498761:HM1 RS09980
gene id: 498761:HM1_RS09980
uniprot id: B0TH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

498761:HM1 RS11225
gene id: 498761:HM1_RS11225
uniprot id: B0TAE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

498761:HM1 RS02975
gene id: 498761:HM1_RS02975
uniprot id: B0TGJ8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

498761:HM1 RS10480
gene id: 498761:HM1_RS10480
uniprot id: B0THQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

498761:HM1 RS02100
gene id: 498761:HM1_RS02100
uniprot id: B0TEM4
names: Similarity
messages: Belongs to the GerABKA family.

498761:HM1 RS04020
gene id: 498761:HM1_RS04020
uniprot id: B0TI65
names: Similarity
messages: Belongs to the UPF0340 family.

498761:HM1 RS12760
gene id: 498761:HM1_RS12760
uniprot id: B0TCE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

498761:HM1 RS12380
gene id: 498761:HM1_RS12380
uniprot id: B0TBX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

498761:HM1 RS03485
gene id: 498761:HM1_RS03485
uniprot id: B0TH41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

498761:HM1 RS11655
gene id: 498761:HM1_RS11655
uniprot id: B0TAY2
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

498761:HM1 RS03040
gene id: 498761:HM1_RS03040
uniprot id: B0TGL1
names: Similarity
messages: Belongs to the disproportionating enzyme family.

498761:HM1 RS06035
gene id: 498761:HM1_RS06035
uniprot id: B0TBR9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

498761:HM1 RS05945
gene id: 498761:HM1_RS05945
uniprot id: B0TBP9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

498761:HM1 RS07280
gene id: 498761:HM1_RS07280
uniprot id: B0TDD5
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

498761:HM1 RS11010
gene id: 498761:HM1_RS11010
uniprot id: B0TIL3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

498761:HM1 RS09365
gene id: 498761:HM1_RS09365
uniprot id: B0TGD8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

498761:HM1 RS01790
gene id: 498761:HM1_RS01790
uniprot id: B0TF30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS08750
gene id: 498761:HM1_RS08750
uniprot id: B0TFS2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

498761:HM1 RS14870
gene id: 498761:HM1_RS14870
uniprot id: B0TEI6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

498761:HM1 RS04550
gene id: 498761:HM1_RS04550
uniprot id: B0TA56
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

498761:HM1 RS08875
gene id: 498761:HM1_RS08875
uniprot id: B0TFU9
names: Similarity
messages: Belongs to the Ahb/Nir family.

498761:HM1 RS02440
gene id: 498761:HM1_RS02440
uniprot id: B0TEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

498761:HM1 RS08720
gene id: 498761:HM1_RS08720
uniprot id: B0TFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

498761:HM1 RS04910
gene id: 498761:HM1_RS04910
uniprot id: B0TAM1
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

498761:HM1 RS04080
gene id: 498761:HM1_RS04080
uniprot id: B0TI77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

498761:HM1 RS05160
gene id: 498761:HM1_RS05160
uniprot id: B0TAS1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

498761:HM1 RS01725
gene id: 498761:HM1_RS01725
uniprot id: B0TF40
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

498761:HM1 RS09555
gene id: 498761:HM1_RS09555
uniprot id: B0TGR2
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS10885
gene id: 498761:HM1_RS10885
uniprot id: B0TII8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

498761:HM1 RS09620
gene id: 498761:HM1_RS09620
uniprot id: B0TGS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

498761:HM1 RS06625
gene id: 498761:HM1_RS06625
uniprot id: B0TCJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS09170
gene id: 498761:HM1_RS09170
uniprot id: B0TG99
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

498761:HM1 RS08955
gene id: 498761:HM1_RS08955
uniprot id: B0TFW8
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

498761:HM1 RS10960
gene id: 498761:HM1_RS10960
uniprot id: B0TIK3
names: Similarity
messages: Belongs to the CobH/CbiC family.

498761:HM1 RS01610
gene id: 498761:HM1_RS01610
uniprot id: B0TFF0
names: Subcellular Location Annotation
messages: Mitochondrion

498761:HM1 RS03470
gene id: 498761:HM1_RS03470
uniprot id: B0TH38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

498761:HM1 RS01915
gene id: 498761:HM1_RS01915
uniprot id: B0TF01
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

498761:HM1 RS12735
gene id: 498761:HM1_RS12735
uniprot id: B0TCE3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS09785
gene id: 498761:HM1_RS09785
uniprot id: B0TGV9
names: Similarity
messages: Belongs to the fabD family.

498761:HM1 RS10580
gene id: 498761:HM1_RS10580
uniprot id: B0THT0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS03985
gene id: 498761:HM1_RS03985
uniprot id: B0TI57
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS12655
gene id: 498761:HM1_RS12655
uniprot id: B0TCC7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

498761:HM1 RS05060
gene id: 498761:HM1_RS05060
uniprot id: B0TAP8
names: Similarity
messages: Belongs to the NifX/NifY family.

498761:HM1 RS06560
gene id: 498761:HM1_RS06560
uniprot id: B0TCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

498761:HM1 RS00310
gene id: 498761:HM1_RS00310
uniprot id: B0TI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS07875
gene id: 498761:HM1_RS07875
uniprot id: B0TES0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

498761:HM1 RS02010
gene id: 498761:HM1_RS02010
uniprot id: B0TEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

498761:HM1 RS06450
gene id: 498761:HM1_RS06450
uniprot id: B0TC90
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS05030
gene id: 498761:HM1_RS05030
uniprot id: B0TAP2
names: Similarity
messages: Belongs to the P(II) protein family.

498761:HM1 RS16250
gene id: 498761:HM1_RS16250
uniprot id: B0TGR7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

498761:HM1 RS06240
gene id: 498761:HM1_RS06240
uniprot id: B0TC51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

498761:HM1 RS10930
gene id: 498761:HM1_RS10930
uniprot id: B0TIJ7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

498761:HM1 RS03780
gene id: 498761:HM1_RS03780
uniprot id: B0THJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS02675
gene id: 498761:HM1_RS02675
uniprot id: B0TDV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

498761:HM1 RS04145
gene id: 498761:HM1_RS04145
uniprot id: B0TI92
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

498761:HM1 RS09585
gene id: 498761:HM1_RS09585
uniprot id: B0TGR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

498761:HM1 RS01140
gene id: 498761:HM1_RS01140
uniprot id: B0TFZ1
names: Similarity
messages: Belongs to the UPF0473 family.

498761:HM1 RS08445
gene id: 498761:HM1_RS08445
uniprot id: B0TFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS07480
gene id: 498761:HM1_RS07480
uniprot id: B0TE31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

498761:HM1 RS13155
gene id: 498761:HM1_RS13155
uniprot id: B0TCU8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

498761:HM1 RS06460
gene id: 498761:HM1_RS06460
uniprot id: B0TC92
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

498761:HM1 RS06205
gene id: 498761:HM1_RS06205
uniprot id: B0TC43
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

498761:HM1 RS01880
gene id: 498761:HM1_RS01880
uniprot id: B0TF10
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

498761:HM1 RS13870
gene id: 498761:HM1_RS13870
uniprot id: B0TDN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

498761:HM1 RS08935
gene id: 498761:HM1_RS08935
uniprot id: B0TFW3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

498761:HM1 RS06695
gene id: 498761:HM1_RS06695
uniprot id: B0TCL9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

498761:HM1 RS10595
gene id: 498761:HM1_RS10595
uniprot id: B0THT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS06495
gene id: 498761:HM1_RS06495
uniprot id: B0TC99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

498761:HM1 RS01425
gene id: 498761:HM1_RS01425
uniprot id: B0TFI7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

498761:HM1 RS00320
gene id: 498761:HM1_RS00320
uniprot id: B0TI24
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

498761:HM1 RS03930
gene id: 498761:HM1_RS03930
uniprot id: B0THM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS04800
gene id: 498761:HM1_RS04800
uniprot id: B0TAB1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

498761:HM1 RS01455
gene id: 498761:HM1_RS01455
uniprot id: B0TFI4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

498761:HM1 RS08560
gene id: 498761:HM1_RS08560
uniprot id: B0TFN1
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

498761:HM1 RS09225
gene id: 498761:HM1_RS09225
uniprot id: B0TGB0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS07560
gene id: 498761:HM1_RS07560
uniprot id: B0TE53
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

498761:HM1 RS05045
gene id: 498761:HM1_RS05045
uniprot id: B0TAP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

498761:HM1 RS08840
gene id: 498761:HM1_RS08840
uniprot id: B0TFU2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

498761:HM1 RS12300
gene id: 498761:HM1_RS12300
uniprot id: B0TBW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

498761:HM1 RS02705
gene id: 498761:HM1_RS02705
uniprot id: B0TDU9
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

498761:HM1 RS00800
gene id: 498761:HM1_RS00800
uniprot id: B0TD09
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

498761:HM1 RS05595
gene id: 498761:HM1_RS05595
uniprot id: B0TB90
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

498761:HM1 RS06895
gene id: 498761:HM1_RS06895
uniprot id: B0TCR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

498761:HM1 RS04605
gene id: 498761:HM1_RS04605
uniprot id: B0TA68
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS08870
gene id: 498761:HM1_RS08870
uniprot id: B0TFU8
names: Similarity
messages: Belongs to the Ahb/Nir family.

498761:HM1 RS01625
gene id: 498761:HM1_RS01625
uniprot id: B0TFE7
names: Subcellular Location Annotation
messages: Membrane

498761:HM1 RS05640
gene id: 498761:HM1_RS05640
uniprot id: B0TBA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

498761:HM1 RS08630
gene id: 498761:HM1_RS08630
uniprot id: B0TFP7
names: Similarity
messages: Belongs to the TrpC family.

498761:HM1 RS09015
gene id: 498761:HM1_RS09015
uniprot id: B0TG63
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

498761:HM1 RS08625
gene id: 498761:HM1_RS08625
uniprot id: B0TFP6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

498761:HM1 RS11285
gene id: 498761:HM1_RS11285
uniprot id: B0TAG1
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

498761:HM1 RS01045
gene id: 498761:HM1_RS01045
uniprot id: B0TG14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.